CN107951813A - A kind of antibacterial anti-inflammatory anti-acne repairs facial mask - Google Patents
A kind of antibacterial anti-inflammatory anti-acne repairs facial mask Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The present invention relates to a kind of antibacterial anti-inflammatory anti-acne to repair facial mask, and being calculated according to weight fraction includes following component：24 parts of component, 13 parts of antibacterial components are repaired in 0.3 0.8 parts of component of removing toxic substances, 0.5 1 parts of blood-activating analgetic component, 35 parts of anti-inflammatory antiseptic ingredient, whitening；10 25 parts of moisturizer, 0.1 0.3 parts of glycerine polymethacrylates, 0.1 0.2 parts of carbomer, 0.1 0.2 parts of xanthans, 0.1 0.4 parts of Sodium Polyacrylate, 60 88 parts of deionized water.Science selection component of the present invention, the various components targetedly acted on are combined togather, more efficiently given play to overall facial mask antibacterial anti-inflammatory anti-acne repair the effect of.Facial mask raw material of the present invention has good biocompatibility because biological transdermal enhancer derives from animal and plant extracts, and skin will not be caused to damage, and has security.
Description
Technical field
Shield skin care item preparing technical field is washed the invention belongs to daily, more particularly to a kind of antibacterial anti-inflammatory anti-acne repair surface
Film.
Background technology
Facial mask, the principle of facial mask, exactly using the of short duration time for being covered in face, is temporarily isolating air and the dirt in the external world
Dye, improves skin temperature, the pore expansion of skin, promotes sweat gland secretion and metabolism, the oxygen content of skin is increased, facial mask
Be conducive to skin and exclude the product of epidermal cell metabolism and the oil substances of accumulation, the moisture infiltration skin table in facial mask
The cuticula of skin, skin become soft, increase elasticity.Necessarily it should be noted that when facial mask is selected professional, safe and healthy non-
It is often important.
Whelk also known as acne, the generation of acne is mainly blocked with hypersteatosis, pilosebaceous duct, bacterium sense
Dye and the factor such as inflammatory reaction are closely related.Adolesce the rapid rise of level of the particularly emerald green ketone of androgen in descendant's body,
Sebaceous glands is promoted to develop and produce a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage, sebum row at the same time
Go out obstacle, form horn plug, that is, micro mist thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction, acne propionic acid in hair follicle
The lipase that bacillus produces decomposes sebum generation free fatty, while chemotactic inflammatory cell and medium, finally induces and aggravates inflammation
Disease is reacted.
With the lifting of people's consumption consciousness, consumer increasingly focuses on product when cleaning product and skin care item are selected
Security, the security of product is much than therapeutic and esthetics itself is important more.Natural plants and the extraction of animal
Thing sensitization rate itself is very low, and security is very high, and the product that production is prepared using this kind of active component extract is also increasingly subject to
The attention of consumer and like.
And the most effect unobvious of facial mask used at present mainly due to production facial mask for play drug effect plant
The extraction efficiency of active material is not high, and destruction is easily produced to active components of plants.Meanwhile for the facial mask containing active material
Middle major part contains a certain amount of preservative ingredient, the addition of the preservative of such skin care item, for long-time service person's
Skin can cause a degree of influence, and the damage for skin surface is larger, once skin is subject to permanent injury not
Easily transfer the original activity of skin to go to repair damage automatically, so that leaving permanent scar the lighter is easily formed dependence
Property.Most facial mask is all based on nursing at the same time, lacks real anti-inflammatory, antibacterial anti-acne action effect.
The content of the invention
For overcome the deficiencies in the prior art, it is an object of the present invention to provide a kind of antibacterial anti-inflammatory anti-acne to repair facial mask and its system
Preparation Method, the facial mask that effectively can solve to produce at present is anti-inflammatory, antibacterial anti-acne effect is poor, carrying for pharmaceutically active substance
Take it is inefficient, containing preservative injury skin, not can effectively prevent the problem of formation of pockmark and acne scar.
The present invention is achieved by the following technical solution：
A kind of antibacterial anti-inflammatory anti-acne repairs facial mask, it is characterised in that being calculated according to weight fraction includes following component：
Component 2-4 is repaired in 0.3-0.8 parts of component of removing toxic substances, 0.5-1 parts of blood-activating analgetic component, 3-5 parts of anti-inflammatory antiseptic ingredient, whitening
Part, 1-3 parts of antibacterial components；10-25 parts of moisturizer, 0.1-0.3 parts of glycerine polymethacrylates, 0.1-0.2 parts of carbomer are yellow
0.1-0.2 parts of virgin rubber, 0.1-0.4 parts of Sodium Polyacrylate, 60-88 parts of deionized water；
It by cantharidin extract and Scolopendra extract according to mass ratio is 1 that the removing toxic substances component, which is,:The composition of 2 compositions；
The blood-activating analgetic component is Eupolyphaga seu steleophaga extract；
It by Changbai Mountain Red Ants extract and perilla leaf extract according to mass ratio is 5 that the anti-inflammatory antiseptic ingredient, which is,:4 compositions
Composition；
It by hirudo extract and honeybee chitin according to mass ratio is 2 that the whitening, which repairs component to be,:The composition of 5 compositions；
The antibacterial components are that aspongopus antibacterial peptide, hornet antibacterial peptide and attacin according to mass ratio are 1:1:1 group
Into composition；
The aspongopus antibacterial peptide is extracted from aspongopus hemolymph；
The moisturizer is dexpanthenol.
Further, the preparation method of the cantharidin extract is as follows：Take Mylabris phalarata drying to clay into power, weigh certain
The Chinese blister beetle powder of quality, then adds the acetone soln of 6 times of volumes, at 25 DEG C, in ultrasonic power 600KHz, ultrasonic extraction
25min, twice, merging filtrate, then by the filtrate 3000r/min after merging, centrifuges 10min, by supernatant concentration extremely for extraction
The 1/3 of former mixing supernatant volume, is cantharidin extract；
The preparation method of the Scolopendra extract is as follows：Claim certain mass takes Centipede, puts in beaker, and precision adds 10 times
The deionized water of volume, at 4 DEG C, in ultrasonic power 600KHz, ultrasonic extraction 35min, twice, merging filtrate, then will for extraction
Filtrate 3000r/min after merging, centrifuge 10min, by supernatant concentration to former mixing supernatant volume 1/3, be centipede
Extract.
Further, the preparation method of the perilla leaf extract specifically includes following steps：By purple perilla leaf raw material through dry
It is dry, beat and 200 mesh sieves crossed after powder, obtain the powder of raw material, then add 95% ethanol solution, in 45 DEG C of water temperature, ultrasonic power
Under the conditions of 200W, ultrasonic extraction 35min, obtains extracting solution；Extracting solution filtering is concentrated under reduced pressure, obtains slurry；By slurry with 1：
10 volume ratios are dissolved in deionized water, agitated, shake up, and obtain perilla leaf extract extract.
Further, the preparation method of the Eupolyphaga seu steleophaga extract is as follows：Ground bettle crude drug is taken, impurity is removed, cleans and do
It is dry, 100 mesh sieves are crossed after beating powder, the powder of raw material is obtained, then adds 60% ethanol solution, in 35 DEG C of water temperature, ultrasonic power
Under the conditions of 200W, ultrasonic extraction 35min, obtains extracting solution；Extracting solution filtering is concentrated under reduced pressure, slurry is obtained, by slurry with 1：6
Volume ratio is dissolved in deionized water, up to ground bettle extracting solution.
Further, the extracting method of the honeybee chitin is as follows：
（1）Sample treatment：Honeybee is rinsed and is placed on 60 DEG C of 24 h of drying of drying box to constant weight, is crushed, up to honeybee sample；
（2）Deproteinization：Sample is placed in water, the mass ratio 1 of sample quality and water:10, add 40% NaOH solution so that
The concentration of final solution is 0.25%, in 40 DEG C of stirring 150min of temperature, is washed above sample to neutrality with clear water；
（3）Decoloration：By step（2）Gained sample is placed in water the mass ratio 1 of sample quality and water:15, use 30% H202
Decoloration, is heated to 75 DEG C, stirs 1h, filtering, it is 7.0 to be washed with distilled water to pH value, 50 DEG C of dryings of baking oven, up to honeybee crust
Element；
The preparation method of the hirudo extract is as follows：
Dry leech is weighed, crushed 200 mesh sieves, precision adds 12 times of water measured after weighing leech coarse powder, in 6.5 DEG C of condition
Under, after soaking 4.9h, suspension is poured into micronizer, is run after setting grinding time 12min；Obtained leech is mixed
Suspension centrifuges, condition 12000r/min, and after centrifuging 10 min, it is hirudo extract to take supernatant.
A kind of antibacterial anti-inflammatory anti-acne repairs the preparation method of facial mask, it is characterised in that includes the following steps：
Step 1: by glycerine polymethacrylates, carbomer, xanthans, Sodium Polyacrylate, moisturizer, deionized water, add
82 DEG C are heated in agitated kettle, stirring and dissolving obtains A completely；
Step 2: treating that A is cooled to 43 DEG C, removing toxic substances component, blood-activating analgetic component are added, component, antibacterial components, stirring are repaired in whitening
B is obtained completely to dissolving；
Step 3: adding anti-inflammatory antiseptic ingredient after B is stirred to dissolving completely, stirring postcooling discharging, obtains final products.
Chinese blister beetle is Meloidae insect, have detumescence by become silted up, dissipating bind disappear note of the ancient Chinese, attack malicious phagedenoma and other effects.Mainly having in Chinese blister beetle
Effect composition is cantharidin, is specific serine and threonine protein phosphatases inhibitor, in cancer cell multiplication and differentiation etc.
Important regulating and controlling effect is played in activity, there are antiviral, increasing leukocyte, antitumor, a variety of drug effects such as Immune-enhancing effect.
Centipede is Arthropoda chilopoda shaping mesh Scolopendridae animal, has ceases wind antispastic, removes obstruction in channels to relieve pain, dispersing pathogen accumulation
And other effects.Contain 15 kinds of aliphatic acid, including linoleic acid, leukotrienes etc. in Scolopndra subspinipes multidens (Newport), 12 kinds of trace elements, 21 kinds of amino acid,
Also the healing of the surface of a wound is contributed to recover with abundant nutrition while with detoxicating functions.
The present invention fully combines effective removing toxic substances component in cantharidin extract and Scolopendra extract so that skin affected part is first
First effectively alleviated, and then be directed to affected part anti-inflammatory again, antibacterial is repaired and whitening, while the abundant nutriment of centipede
Recovery also for skin affected part provides certain booster action.
Ant category Arthropoda Insecta Hymenoptera: Formicidae animal, ant is maximum as living nature quantity, eats, is medicinal double
The high insect of weight effect, for a long time, although being subject to many people favor of different regions, different nationalities in the world, with food
The development of product and medical science, people have brand-new understanding for the medical care effect of ant.Since ant has generally
The effect of unrivaled Kidney and Liver protection of material, enhancing immunity of organisms.Therefore, it can be more in the application prospect of medical field
It is wide.
Changbai Mountain Red Ants body inner protein 45%-65%, containing 24 kinds of amino acid, wherein, including amino needed by human
The content of 8 kinds of acid, and calcic, iron, zinc and vitamin E, the various trace elements such as B1, B2 and B12 and vitamin, especially zinc
Extremely abundant, the experimental study through pharmacology and immune function to red ant shows, it has, and obvious anti-inflammatory is antibacterial, antioxygen
Change, the calm and protect liver etc. that supplements the nutrients effect, have dual regulation to human immunity.
Contain a variety of important active ingredients, perilla alcohol, menthones, eugenol and other furanones therein in perilla leaf
Red pigments anthocyanidin -3- (6- is to coumaric acyl-β-D-Glucose) -5- β-D-Glucose glucoside in derivative and leaf can rise
To natural anti-corrosion, the effect of anti-oxidant anti-inflammatory.
Perilla leaf together constitutes antiseptic ingredient with Changbai Mountain Red Ants extract in the present invention, is risen in whole system
To antisepsis, without additionally adding the preservative of industrial products class again, guarantee is provided for the security of product of the present invention,
Meanwhile skin will not be damaged.
Ground bettle begins to be recorded in《Sheng Nong's herbal classic》One of, the Chinese medicine used for China's folk tradition, it is widely used in treatment
Various Blood stasis, have promoting blood circulation and removing blood stasis, assault fortified position brokenly product, inducing meastruation to relieve menalgia and other effects.Wherein contain volatile oil and amino acid composition；Volatilization
Oily total amount about 22.19%, master is naphthalene, separately containing various fatty aldehydes and aromatic aldehyde, accounts for 24.95%.Also contain dichloro-benzenes and dimethyl two
The rare component of other Chinese medicines such as thioether.Total amino acid content accounts for 40%, and amino acid needed by human accounts for total amino acid content
More than 30%, another sitosterol containing b-.Using ground bettle self component and the advantage of effect, blood-activating analgetic component of the invention is soil
Soft-shelled turtle worm extract, can relieve pain stagnation resolvation while removing toxic substances, and then cure affected part wound repairing.
Antibacterial peptide is the defensive bioactive peptide material of one kind that animal immune system of defense is produced through induction, can resist external source
The pathogenic effects of pathogen, are an important components of animal body fluid system of defense.Extracted in marine organisms body
Peptide matters with antibacterial activity.They have the characteristics that some are common:Majority is the cationic point rich in cysteine
Son;Molecular weight is generally in below 10kDa;With broad spectrum antibiotic activity, and bacterium is not easy to produce drug resistance to it.And antibacterial
Peptide can play the role of preservative as natural anti-corrosion composition in skin care item and cleaning kind in itself, it is not necessary to extra addition
Any preservative, natural preservative ingredient will not produce skin any stimulation, safe and non-toxic, cause the several of skin allergy
Rate is very low.Antibacterial peptide can not only kill propionibacterium acnes, and have significant its caused inflammation inflammation of reduction of energy
Effect and potentiality.The present invention uses the synergetic antibacterial effect of aspongopus antibacterial peptide, hornet antibacterial peptide and attacin, antibacterial
Effect is more preferable, is not likely to produce drug resistance, noresidue, and natural anticorrosion is safer.
Aspongopus, i.e. Semiptera, Heteroptera.It is a kind of lividity insect that can be winged, size as nail, shape such as terrapin.
In spring and summer season, climb on the cauline leaf of crops and suck slurries, does not pay attention to and runs into it, just releases a kind of unpleasant gas of cacosmia, make
People shies away, thus falls " a smelly plate worm ", the notorious reputation of " wind bar worm " or " beating wind worm ".Wind bar worm contains aspongopus oil, once
It is a kind of fragrant U.S. tasty, medicinal cuisines for eliminating disease and prolong life, therefore, it has won the laudatory title of " aspongopus " again after frying.Nine
Fragrant worm antibacterial peptide have efficiently, low toxicity, broad spectrum antibacterial, aspongopus polypide is full of nutrition, polypide containing significant quantities of fat, protein and
Chitin component.
Antibacterial peptide and albumen in insect body fluid immune dependent hemolymph.Under non-induced state, insect has foundation level table
The antibacterial peptide reached；Under induction state (environmental stimuli or infection), high level expression is presented in antibacterial peptide in insect bodies.Therefore,
When extracting antibacterial peptide, generally first insect will be induced, common abductive approach is to use microorganism infection.
Induction processing for aspongopus is as follows：By Escherichia coli and staphylococcus aureus in LB fluid nutrient mediums mistake
Night cultivates, and respectively takes isometric bacterium solution to mix, and 5000r/min centrifuges 5 min and collects thalline, and it is heavy to be resuspended with sterile saline
Form sediment, concentration is adjusted to 1*108CFU/mL, as induction source.Mixed bacteria liquid is dipped with transfer needle, it is light to be pierced into aspongopus adult belly,
Continue to extract its hemolymph after raising 24h.
Lymph blood extracts：The aspongopus individual survived after 24 h of immune induction is taken, head, foot and wing is removed, polypide is cut
Into two, then with tweezers by each half tear.5 per treatment, coprocessing 50-100 heads.The small centrifuge tube of a 6mL is taken, outside
The big centrifuge tube of a 10mL in surface cover.Drill below this 6mL centrifuge tube, interior pad warp layer cloth；Contain in 10mL centrifuge tubes
There are phenylthiourea (0.1 mg/mL hemolymphs of final concentration), 10 μ g/mL PMSF and 10 μ g/mL Aprotinins, for collecting blood strangury
Bar.The aspongopus torn is put into small centrifuge tube, the weak yellow liquid in 10000r/min 20 min of centrifugation, big centrifuge tube
As aspongopus hemolymph.
Such peptide antibiotics of attacin typically contain 37-39 amino acid residue, without cysteine, its N-terminal
Region has strong basicity, can form parents' helical structure of almost Perfect, and hydrophobic helices can be formed in C-terminal region, both it
Between have the hinge area that glycine and proline are formed, the C-terminal of most polypeptides is amidated, and amidatioon has weight to its antibacterial activity
Act on.Cecropin antimicrobial peptides antibacterial wide spectrum, be not likely to produce the resistance to the action of a drug, has the potential as new class medicine, has wide
Application prospect.
Wasp adult, larva and honeycomb can enter Chinese medicine.Or for oral administration, or external application, can control poisonous insect sting sting, the disease such as carbuncle, itself
Just there is removing toxic substances, it also has effects that to control sparrow brood spot, pimples.Hornet antibacterial peptide derives from the venom of honeybee, tool
There is powerful antibiotic and sterilizing.
Leech, popular name leech,《Sheng Nong's herbal classic》In have been described, there is very high medical value, be Chinese tradition
Extraordinary medicinal aquatic animal, the traditional Chinese medical science is used as medicine after its dried product is brewed, has the good clear stasis of blood, treats the effect of traumatic injury.
Leech has very high value of being used as medicine in itself, is used as medicine by dry entirety, containing hirudin and abundant protein, in leech
In 17 kinds of contained amino acid, wherein 7 kinds are essential amino acid, its content is 1535mg/100g dry weights, accounts for whole amino
The 72% of sour total quantity.Also invigorate blood circulation, dissipate the effect of stasis of blood, promoting menstruation.The low molecule that hirudin therein is made of 65 amino acid
The content of amount polypeptide, its glutamine and asparagine is higher, and isoelectric point is relatively low, at room temperature steadily in the long term.Leech
Have very much very abundant trace element in vivo, the wherein content of Zn-ef ficiency is 8 times higher than the Zn content in soybean, than in pork liver
Content is 2 times high.Zn-ef ficiency widely participates in the basic biochemical process such as the metabolism of protease, carbohydrate, nucleic acid, fat, it is known to
The activity of more than 300 kinds of enzyme is related with zinc.
Therefore, hirudo extract can cooperate with the problems such as other components solve small pox jointly, the colour of skin caused by acne is obscure,
There is preferable whitening wrinkle improvement effect, skin regeneration can be promoted and improve skin quality;Detoxify in other components of the present invention, anti-inflammatory is antibacterial
Effect after also play the role of repairing pockmark and skin whitening well.
Soybean dietary fiber extraction be in the state of medicinal material and solvent coexist, using powerful mechanical oscillation tissue abrasion,
Solvent is set to reach organization internal rapidly, by reducing medicinal material particle diameter, increase dissolution area, shortening component dissolution path, so as to carry
A kind of extraction new technology of high extracting efficiency.Its principle is during soybean dietary fiber that the dissolution of active ingredient is except tool
Have outside the advantage that diffusional resistance is small, dissolution path is short, dissolution area is big, the herb in granule form for absorbing solvent is also constantly subject to machine
Shearing, the extruding of tool power, until reaching Cellular Level Pulverizing, these mechanical forces substantially increase the convection current of solvent, improve matter
Carry-over factor is measured, promotes active ingredient promptly to be shifted to solvent.The hirudo extract of the present invention is exactly to be obtained by this kind of method
.
The advantages of chitin extracted from honeybee：Chitin content is of a relatively high in honeybee, and separating technology is easy, raw material
Abundance, properties of product are excellent.Chitin is a kind of macromolecule polysaccharide of line style, i.e., natural neutral mucopolysacchauide, if through dense
Alkali process removes acetyl group up to chitosan.Torpescence on chitin chemistry, does not change with body fluid, to organizing not
Rise foreign body reaction, it is nontoxic, it is high temperature-resistant disinfected the features such as.The chitin of deacetylate is alkaline polysaccharide, there is only acid, easily suction
Receive, anti-inflammatory, activating cell, the effect of wound healing.Component in reparation whitening component in the present invention can be effective
The impaired skin of offer needed for nutrition, timely wound repairing is helped, in combination with the whitening function of hirudo extract, so as to reach
To the effect for repairing whitening.
The reparation technology flow of honeybee chitin in the present invention:Sampling-de- albumen-decoloration-purifying drying.
（1）Sample treatment：Honeybee is rinsed and is placed on 60 DEG C of 24 h of drying of drying box to constant weight, is crushed, up to honeybee sample
Product.
（2）Deproteinization：Sample is placed in water, the mass ratio 1 of sample quality and water:10,40% NaOH solution is added, is made
The concentration for obtaining final solution is 0.25%, in 40 DEG C of stirring 150min of temperature, is washed above sample to neutrality with clear water.
（3）Decoloration：By step（2）Gained sample is placed in water the mass ratio 1 of sample quality and water:15, use 30%
H202Decoloration, is heated to 75 DEG C, stirs 1h, filtering, it is 7.0 to be washed with distilled water to pH value, 50 DEG C of dryings of baking oven, up to honeybee
Chitin.
Dexpanthenol is a kind of permeability moisturizer, and tool deep moisturizing effect, can pass through skin, keep hair and skin
In moisture；Energy nutrition hair and skin, make skin lubrication, resist drying, cracking, hair is bright, not easy entanglement.Dexpanthenol
It is a kind of excellent skin and hair-protecting agent, the division growth of cell can be stimulated, the hyperplasia of augmentor fiber sprout cell, there is assistance
The function of repairing skin tissue.Have anti-inflammatory and the effect for the superficial wound that heals, and other compositions in formula can be mitigated（Surface-active
Agent etc.）Stimulation to skin and the damage to hair.With uvioresistant, sun-proof effect.
Antibacterial anti-inflammatory anti-acne of the present invention is repaired facial mask and preparation method thereof and is had the advantages that：
1st, antibacterial anti-inflammatory anti-acne of the present invention repairs facial mask and preparation method thereof and combines full insects product Chinese medicine compound collecting first
Active ingredient in thing, is prepared without preservative, non-stimulated, the antibacterial anti-acne of efficient anti-inflammatory, the pure day of anti-acne trace skin whitening
Right facial mask.The present invention is added without any industrial goods preservative, has safe and non-toxic natural antiseptic agent, good water solubility, heat in component
Stability is good, sphere of action is wide.
2nd, antibacterial anti-inflammatory anti-acne of the present invention is repaired extract most in facial mask and preparation method thereof and is carried using ultrasonic wave
Follow the example of and carry, the technique extraction efficiency is high, and for plant, the active ingredient utilization rate in polypide medicine is high, not waste of resource.This
Invention prepares extract using ultrasonic extraction, utilizes the judder of ultrasonic wave generation, higher acceleration, strong sky
The special effects such as changing effect, stirring, can destroy plant cell, solvent is penetrated into Materials Cell, promote raw material to be extracted
In chemical composition be dissolved in solvent, then required chemical composition is drawn by separating-purifying.Utilize ultrasonic wave extraction 30min ratios
The recovery rate of conventional decocting method extraction 3h will be higher by 9%.
Meanwhile hirudo extract of the invention is exactly to be obtained by soybean dietary fiber extracting method.Wet method Ultramicro-powder
Broken extraction is in the state of medicinal material and solvent coexist, and using powerful mechanical oscillation tissue abrasion, solvent is reached tissue rapidly
Inside, by reducing medicinal material particle diameter, increase dissolution area, shortening component dissolution path, so that the one kind for improving extraction efficiency carries
Take new technology.Its principle is during soybean dietary fiber, and the dissolution of active ingredient is except with diffusional resistance is small, dissolution road
Outside the advantage that footpath is short, dissolution area is big, the herb in granule form for absorbing solvent is also constantly sheared be subject to mechanical force, extruded, directly
To Cellular Level Pulverizing is reached, these mechanical forces substantially increase the convection current of solvent, improve mass transfer coefficient, promote effectively
Component is promptly shifted to solvent.
3rd, antibacterial anti-inflammatory anti-acne of the present invention repair be effectively combined in facial mask and preparation method thereof perilla leaf extract with
Changbai Mountain Red Ants extract together constitutes antiseptic ingredient and forms natural effective preservative system, without especially adding,
Pro-skin is non-stimulated, also reduces cost.
4th, antibacterial anti-inflammatory anti-acne of the present invention is repaired in facial mask and preparation method thereof cleverly by the amino in honeybee chitin
The nutritional ingredient of the promotions such as acid, vitamin healing, effective antibacterial anti-inflammatory component in Changbai Mountain Red Ants extract, Chinese blister beetle extraction
The removing toxic substances component of thing and Scolopendra extract, the promoting blood circulation and removing blood stasis and component of removing obstruction in channels to relieve pain in Eupolyphaga seu steleophaga extract, in hirudo extract
Whitening and softening skin, remove the obscure component for removing scar, the antisepsis that cooperates with of perilla leaf extract and Changbai Mountain Red Ants extract, and nine
The synergetic antibacterial effect of fragrant worm antibacterial peptide, hornet antibacterial peptide and attacin, and the moisture-keeping function of dexpanthenol, respectively
The component that kind targetedly acts on is combined togather, and has more efficiently given play to the antibacterial anti-inflammatory anti-acne reparation of overall facial mask
Effect, is prepared for a kind of pure natural, mask product of non-stimulated and efficient anti-acne.
5th, antibacterial anti-inflammatory anti-acne of the present invention repairs facial mask and preparation method thereof, because biological transdermal enhancer derives from animal
Plant extracts, has good biocompatibility, and skin will not be caused to damage, and has security.The present invention is adopted
Moisturizer dexpanthenol is a kind of permeability moisturizer, and tool deep moisturizing effect, can pass through skin, keep hair and skin
Moisture in skin.Dexpanthenol is a kind of excellent skin and hair-protecting agent, can stimulate the division growth of cell, is promoted fine
The hyperplasia of sprout cell is tieed up, there is the function of assisting repairing skin tissue.Have anti-inflammatory and the effect for the superficial wound that heals, and can mitigate and match somebody with somebody
Stimulation of other compositions to skin and the damage to hair in side.With uvioresistant, sun-proof effect.Moisturizer has again in itself
There is anti-inflammatory to promote healing and assist the function of repairing skin tissue, the anti-inflammatory repairing performance for whole product plays synergy
Effect.
Embodiment
The invention discloses a kind of antibacterial anti-inflammatory anti-acne to repair facial mask and preparation method thereof with reference to specific embodiments
The present invention will be further described：
Embodiment 1：
Antibacterial anti-inflammatory anti-acne repairs facial mask, and being calculated according to weight fraction includes following component：
2 parts of component, antibacterial components 1 are repaired in 0.3 part of component of removing toxic substances, 0.5 part of blood-activating analgetic component, 3 parts of anti-inflammatory antiseptic ingredient, whitening
Part；10 parts of moisturizer, 0.1 part of glycerine polymethacrylates, 0.1 part of carbomer, 0.1 part of xanthans, Sodium Polyacrylate 0.1
Part, 60 parts of deionized water；It by cantharidin extract and Scolopendra extract according to mass ratio is 1 that removing toxic substances component, which is,:The combination of 2 compositions
Thing；Blood-activating analgetic component is Eupolyphaga seu steleophaga extract；Anti-inflammatory antiseptic ingredient is extracted by Changbai Mountain Red Ants extract and perilla leaf
Thing is 5 according to mass ratio:The composition of 4 compositions；It is according to quality by hirudo extract and honeybee chitin that component is repaired in whitening
Than for 2:The composition of 5 compositions；Antibacterial components are aspongopus antibacterial peptide, hornet antibacterial peptide and attacin according to mass ratio
For 1:1:The composition of 1 composition；Aspongopus antibacterial peptide is extracted from aspongopus hemolymph；Moisturizer is dexpanthenol.
Embodiment 2：
Antibacterial anti-inflammatory anti-acne repairs facial mask, and being calculated according to weight fraction includes following component：
3 parts of component, antibacterial components 2 are repaired in 0.6 part of component of removing toxic substances, 0.8 part of blood-activating analgetic component, 4 parts of anti-inflammatory antiseptic ingredient, whitening
Part；20 parts of moisturizer, 0.2 part of glycerine polymethacrylates, 0.2 part of carbomer, 0.2 part of xanthans, Sodium Polyacrylate 0.3
Part, 78 parts of deionized water；It by cantharidin extract and Scolopendra extract according to mass ratio is 1 that removing toxic substances component, which is,:The combination of 2 compositions
Thing；Blood-activating analgetic component is Eupolyphaga seu steleophaga extract；Anti-inflammatory antiseptic ingredient is extracted by Changbai Mountain Red Ants extract and perilla leaf
Thing is 5 according to mass ratio:The composition of 4 compositions；It is according to quality by hirudo extract and honeybee chitin that component is repaired in whitening
Than for 2:The composition of 5 compositions；Antibacterial components are aspongopus antibacterial peptide, hornet antibacterial peptide and attacin according to mass ratio
For 1:1:The composition of 1 composition；Aspongopus antibacterial peptide is extracted from aspongopus hemolymph；Moisturizer is dexpanthenol.
Embodiment 3：
Antibacterial anti-inflammatory anti-acne repairs facial mask, and being calculated according to weight fraction includes following component：
4 parts of component, antibacterial components 3 are repaired in 0.8 part of component of removing toxic substances, 1 part of blood-activating analgetic component, 5 parts of anti-inflammatory antiseptic ingredient, whitening
Part；25 parts of moisturizer, 0.3 part of glycerine polymethacrylates, 0.2 part of carbomer, 0.2 part of xanthans, Sodium Polyacrylate 0.4
Part, 88 parts of deionized water；It by cantharidin extract and Scolopendra extract according to mass ratio is 1 that removing toxic substances component, which is,:The combination of 2 compositions
Thing；Blood-activating analgetic component is Eupolyphaga seu steleophaga extract；Anti-inflammatory antiseptic ingredient is extracted by Changbai Mountain Red Ants extract and perilla leaf
Thing is 5 according to mass ratio:The composition of 4 compositions；It is according to quality by hirudo extract and honeybee chitin that component is repaired in whitening
Than for 2:The composition of 5 compositions；Antibacterial components are aspongopus antibacterial peptide, hornet antibacterial peptide and attacin according to mass ratio
For 1:1:The composition of 1 composition；Aspongopus antibacterial peptide is extracted from aspongopus hemolymph；Moisturizer is dexpanthenol.
Raw material extracting method in each embodiment is as follows：
The preparation method of cantharidin extract is as follows：Take Mylabris phalarata drying to clay into power, weigh the Chinese blister beetle powder of certain mass,
Then the acetone soln of 6 times of volumes is added, at 25 DEG C, in ultrasonic power 600KHz, ultrasonic extraction 25min, extraction twice, merges
Filtrate, then by the filtrate 3000r/min after merging, centrifuges 10min, by supernatant concentration to former mixing supernatant volume 1/
3, it is cantharidin extract.
The preparation method of Scolopendra extract is as follows：Claim certain mass takes Centipede, puts in beaker, precision plus 10 times of bodies
Long-pending deionized water, at 4 DEG C, in ultrasonic power 600KHz, ultrasonic extraction 35min, twice, merging filtrate, then will close for extraction
Filtrate 3000r/min after and, centrifuge 10min, by supernatant concentration to former mixing supernatant volume 1/3, be centipede carry
Take thing.
The preparation method of perilla leaf extract specifically includes following steps：By purple perilla leaf raw material through drying, beat powder after cross 200
Mesh sieve, obtains the powder of raw material, then adds 95% ethanol solution, under the conditions of 45 DEG C of water temperature, ultrasonic power 200W, ultrasound
35min is extracted, obtains extracting solution；Extracting solution filtering is concentrated under reduced pressure, obtains slurry；By slurry with 1：10 volume ratios be dissolved in from
It is agitated, shake up in sub- water, obtain perilla leaf extract extract.
Take Changbai Mountain Red Ants drying to clay into power, weigh the Changbai Mountain Red Ants powder of certain mass, then add 10
80% ethanol solution of times volume, at 25 DEG C, in ultrasonic power 600KHz, ultrasonic extraction 20min, extraction twice, merges filter
Liquid, then by the filtrate 3000r/min after merging, centrifuges 10min, by supernatant concentration to former mixing supernatant volume 1/3,
As Changbai Mountain Red Ants extract.
The preparation method of Eupolyphaga seu steleophaga extract is as follows：Ground bettle crude drug is taken, impurity, clean dry is removed, beats mistake after powder
100 mesh sieves, obtain the powder of raw material, then add 60% ethanol solution, under the conditions of 35 DEG C of water temperature, ultrasonic power 200W, surpass
Sound extracts 35min, obtains extracting solution；Extracting solution filtering is concentrated under reduced pressure, slurry is obtained, by slurry with 1：6 volume ratios are dissolved in
In ionized water, up to ground bettle extracting solution.
The hirudo extract of the present invention is exactly to be obtained by soybean dietary fiber extracting method.Soybean dietary fiber extracts
It is in the state of medicinal material and solvent coexist, using powerful mechanical oscillation tissue abrasion, solvent is reached organization internal rapidly, leads to
Cross and reduce medicinal material particle diameter, increase dissolution area, shorten component dissolution path, extract new skill so as to improve one kind of extraction efficiency
Art.Its principle is during soybean dietary fiber, the dissolution of active ingredient except with diffusional resistance is small, dissolution path is short,
Outside the big advantage of dissolution area, the herb in granule form for absorbing solvent is also constantly sheared be subject to mechanical force, extruded, until reaching
Cellular Level Pulverizing, these mechanical forces substantially increase the convection current of solvent, improve mass transfer coefficient, promote active ingredient fast
Fastly shifted to solvent.
Dry leech is weighed, crushed 200 mesh sieves, precision adds 12 times of water measured after weighing leech coarse powder, at 6.5 DEG C
Under the conditions of, after soaking 4.9h, suspension is poured into micronizer, is run after setting grinding time 12min；The water that will be obtained
Leech suspension centrifuges, condition 12000r/min, and after centrifuging 10 min, it is hirudo extract to take supernatant.
The reparation technology flow of honeybee chitin in the present invention:Sampling-de- albumen-decoloration-purifying drying.
（1）Sample treatment：Honeybee is rinsed and is placed on 60 DEG C of 24 h of drying of drying box to constant weight, is crushed, up to honeybee sample
Product.
（2）Deproteinization：Sample is placed in water, the mass ratio 1 of sample quality and water:10,40% NaOH solution is added, is made
The concentration for obtaining final solution is 0.25%, in 40 DEG C of stirring 150min of temperature, is washed above sample to neutrality with clear water.
（3）Decoloration：By step（2）Gained sample is placed in water the mass ratio 1 of sample quality and water:15, use 30%
H202 decolourizes, and is heated to 75 DEG C, stirs 1h, filtering, it is 7.0 to be washed with distilled water to pH value, 50 DEG C of dryings of baking oven, up to honeybee
Chitin.
If the not special furnace drying method and condition mentioned for raw material in the present invention, the drying of general option conventional vacuum
Case, sets drying temperature as 40 DEG C, drying time 24h.
Antibacterial anti-inflammatory anti-acne repair surface membrane preparation method in embodiment includes the following steps：
Step 1: by glycerine polymethacrylates, carbomer, xanthans, Sodium Polyacrylate, moisturizer, deionized water, add
82 DEG C are heated in agitated kettle, stirring and dissolving obtains A completely；
Step 2: treating that A is cooled to 43 DEG C, removing toxic substances component, blood-activating analgetic component are added, component, antibacterial components, stirring are repaired in whitening
B is obtained completely to dissolving；
Step 3: adding anti-inflammatory antiseptic ingredient after B is stirred to dissolving completely, stirring postcooling discharging, obtains final products.
The evaluation of facial mask and preparation method thereof effect is repaired on antibacterial anti-inflammatory anti-acne of the present invention：
The application method of facial mask of the present invention：1st, the Skin sensitization test before surface application should be carried out first, mainly thorough clean skin, or massaging
Afterwards with hot towel surface application three minutes, after expanding pore, facial mask is reused.Usual weaving formula facial mask applies 10~15 minutes.
2nd, massage：After weaving formula facial mask is removed, the nutritional ingredient that can be retained by face coordinates massage, makes facial mask
Effect doubles, can be with toxin expelling and firm skin.
Human skin irritation is tested
Select male, women each 200 of the age at 18-28 Sui, after continuous use 7 days, observation skin whether red and swollen, oedema, 7 days
The test result fed back afterwards occurs for 400 study subjects without red and swollen, oedema phenomenon, show the facial mask of the present invention to skin without
Any stimulation, the people that may adapt to various skins use.
Acne repairing effect is gone to detect
After selecting the face of 300 18-28 one full year of life to have acne patient continuously to try out four weeks, it is divided into three groups of every group of 100 people feedbacks and goes acne
Repairing effect.The facial mask that effect detection of the present invention uses is the product being prepared in the embodiment of the present invention 3.
Wherein, effective oneself to think that small pox substantially mitigates, three groups of the number that the surface of a wound is clearly better is respectively 70 people, 80 people
With 75 people；It is respectively 30 people, 20 people and 25 people effectively oneself to think that small pox has mitigated three groups of the number that the surface of a wound makes moderate progress；
It is invalid oneself to think that small pox mitigates unobvious or is 0 people without three groups of the number of mitigation also no repairing effect.From inspection
Survey from the point of view of result, three groups of significant effect rate, that is, obvious effective rate is respectively 70%, 80% and 75%, and three groups of average obvious effective rate is 75%.
Prove that the antibacterial anti-inflammatory anti-acne of the present invention repairs facial mask and has very excellent anti-inflammatory anti-acne and repair using effect.If at the same time
The long-term facial mask adhered to using the present invention, can also effectively resist the extraneous and oxidative factors of itself, and resistance pigment sinks
The formation of product and pockmark and acne scar again can be with skin whitening.
Antibacterial anti-inflammatory anti-acne of the present invention repair in facial mask and preparation method thereof cleverly by the amino acid in honeybee chitin,
The nutritional ingredient of the promotions such as vitamin healing, effective antibacterial anti-inflammatory component, cantharidin extract in Changbai Mountain Red Ants extract
With the removing toxic substances component of Scolopendra extract, the promoting blood circulation and removing blood stasis and component of removing obstruction in channels to relieve pain in Eupolyphaga seu steleophaga extract, hirudo extract Sino-U.S.
Delicate skin, go the obscure component for removing scar, perilla leaf extract and the antisepsis that cooperates with of Changbai Mountain Red Ants extract, and nine is fragrant
The synergetic antibacterial effect of worm antibacterial peptide, hornet antibacterial peptide and attacin, and the moisture-keeping function of dexpanthenol, it is various
The component targetedly acted on is combined togather, and has more efficiently given play to the work(of the antibacterial anti-inflammatory anti-acne reparation of overall facial mask
Effect, is prepared for a kind of pure natural, mask product of non-stimulated and efficient anti-acne.Examined it can be said that product of the present invention is comprehensive
The removing toxic substances needed for the patient with small pox, acne skin, stagnation resolvation, anti-inflammatory, antibacterial, reparation, a variety of need of whitening are considered
Ask, science selects raw material and component proportion, and the component of various effects of raw material is synergistic, with reference to bringing out the best in each other, is made
The mask product of perfect efficiency of the present invention.
Exemplary description is carried out to the present invention above in conjunction with specific embodiment, it is clear that realization of the invention and from upper
The limitation of mode is stated, if the various improvement of inventive concept and technical scheme of the present invention progress are employed, or not improved general
The design and technical solution of the present invention directly applies to other occasions, within the scope of the present invention.
Claims (5)
1. a kind of antibacterial anti-inflammatory anti-acne repairs facial mask, it is characterised in that being calculated according to weight fraction includes following component：
Component 2-4 is repaired in 0.3-0.8 parts of component of removing toxic substances, 0.5-1 parts of blood-activating analgetic component, 3-5 parts of anti-inflammatory antiseptic ingredient, whitening
Part, 1-3 parts of antibacterial components；10-25 parts of moisturizer, 0.1-0.3 parts of glycerine polymethacrylates, 0.1-0.2 parts of carbomer are yellow
0.1-0.2 parts of virgin rubber, 0.1-0.4 parts of Sodium Polyacrylate, 60-88 parts of deionized water；
It by cantharidin extract and Scolopendra extract according to mass ratio is 1 that the removing toxic substances component, which is,:The composition of 2 compositions；
The blood-activating analgetic component is Eupolyphaga seu steleophaga extract；
It by Changbai Mountain Red Ants extract and perilla leaf extract according to mass ratio is 5 that the anti-inflammatory antiseptic ingredient, which is,:4 compositions
Composition；
It by hirudo extract and honeybee chitin according to mass ratio is 2 that the whitening, which repairs component to be,:The composition of 5 compositions；
The antibacterial components are that aspongopus antibacterial peptide, hornet antibacterial peptide and attacin according to mass ratio are 1:1:1 group
Into composition；
The aspongopus antibacterial peptide is extracted from aspongopus hemolymph；
The moisturizer is dexpanthenol.
2. antibacterial anti-inflammatory anti-acne according to claim 1 repairs facial mask, it is characterised in that：
The preparation method of the cantharidin extract is as follows：Take Mylabris phalarata drying to clay into power, weigh the Chinese blister beetle of certain mass
Powder, then adds the acetone soln of 6 times of volumes, at 25 DEG C, in ultrasonic power 600KHz, ultrasonic extraction 25min, extraction two
Secondary, merging filtrate, then by the filtrate 3000r/min after merging, centrifuges 10min, by supernatant concentration to former mixing supernatant
The 1/3 of volume, is cantharidin extract；
The preparation method of the Scolopendra extract is as follows：Claim certain mass takes Centipede, puts in beaker, and precision adds 10 times
The deionized water of volume, at 4 DEG C, in ultrasonic power 600KHz, ultrasonic extraction 35min, twice, merging filtrate, then will for extraction
Filtrate 3000r/min after merging, centrifuge 10min, by supernatant concentration to former mixing supernatant volume 1/3, be centipede
Extract.
3. antibacterial anti-inflammatory anti-acne according to claim 1 or 2 repairs facial mask, it is characterised in that：The perilla leaf extraction
The preparation method of thing specifically includes following steps：By purple perilla leaf raw material through drying, beat powder after cross 200 mesh sieves, obtain the powder of raw material
Shape thing, then adds 95% ethanol solution, and under the conditions of 45 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 35min, must extract
Liquid；Extracting solution filtering is concentrated under reduced pressure, obtains slurry；By slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake
It is even, obtain perilla leaf extract extract.
4. antibacterial anti-inflammatory anti-acne according to claim 3 repairs facial mask and preparation method thereof, it is characterised in that：The ground beetle
The preparation method of worm extract is as follows：Ground bettle crude drug is taken, removes impurity, clean dry, 100 mesh sieves is crossed after beating powder, obtains
The powder of raw material, then adds 60% ethanol solution, under the conditions of 35 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 35min,
Obtain extracting solution；Extracting solution filtering is concentrated under reduced pressure, slurry is obtained, by slurry with 1：6 volume ratios are dissolved in deionized water, to obtain the final product
Ground bettle extracting solution.
5. the antibacterial anti-inflammatory anti-acne according to claim 1-4 repairs facial mask, it is characterised in that：
The extracting method of the honeybee chitin is as follows：
（1）Sample treatment：Honeybee is rinsed and is placed on 60 DEG C of 24 h of drying of drying box to constant weight, is crushed, up to honeybee sample；
（2）Deproteinization：Sample is placed in water, the mass ratio 1 of sample quality and water:10, add 40% NaOH solution so that most
The concentration of whole solution is 0.25%, in 40 DEG C of stirring 150min of temperature, is washed above sample to neutrality with clear water；
（3）Decoloration：By step（2）Gained sample is placed in water the mass ratio 1 of sample quality and water:15, use 30% H202It is de-
Color, is heated to 75 DEG C, stirs 1h, filtering, it is 7.0 to be washed with distilled water to pH value, 50 DEG C of dryings of baking oven, up to honeybee crust
Element；
The preparation method of the hirudo extract is as follows：
Dry leech is weighed, crushed 200 mesh sieves, precision adds 12 times of water measured after weighing leech coarse powder, in 6.5 DEG C of condition
Under, after soaking 4.9h, suspension is poured into micronizer, is run after setting grinding time 12min；Obtained leech is mixed
Suspension centrifuges, condition 12000r/min, and after centrifuging 10 min, it is hirudo extract to take supernatant.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109381357A (en) * | 2018-12-13 | 2019-02-26 | 广州宝莱生物科技有限公司 | A kind of anti-acne moisturizing leech freeze-dried powder |
-
2017
- 2017-12-20 CN CN201711384662.3A patent/CN107951813A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 国家食品药品监督管理总局: "《化妆品安全技术规范（2015年版）》", 23 December 2015 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109381357A (en) * | 2018-12-13 | 2019-02-26 | 广州宝莱生物科技有限公司 | A kind of anti-acne moisturizing leech freeze-dried powder |
| CN109381357B (en) * | 2018-12-13 | 2021-09-03 | 广州宝莱生物科技有限公司 | Leech freeze-dried powder capable of removing acne and moisturizing skin |
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