CN104474536A - Fresh agrimonia pilosa medicine preparation for treating wounds - Google Patents
Fresh agrimonia pilosa medicine preparation for treating wounds Download PDFInfo
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- CN104474536A CN104474536A CN201410658121.5A CN201410658121A CN104474536A CN 104474536 A CN104474536 A CN 104474536A CN 201410658121 A CN201410658121 A CN 201410658121A CN 104474536 A CN104474536 A CN 104474536A
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Abstract
The invention relates to the technical field of fresh traditional Chinese medicine processing; powder processed from fresh agrimonia pilosa traditional Chinese medicine which is preserved by low temperature and lysozyme are processed into a new medicine preparation. Compared with the traditional Chinese medicine preparation manner, the preserved fresh agrimonia pilosa powder improves the retention and application of active ingredients of the medicine, the medicine can be applied to hemostasis, convergence, heal and anti-inflammatory of the wound, and quickly becomes effective and is good in effect. The preparation promotes the heal and incrustation of the wound surface and promotes the wound surface to be dried, the powder (wetted) is not adhered with the wound surface in general, and is easy to clean after being used and leaving small scar after cure; the wound surface of small-area surgery injury at the skin of a movable joint scabs within 12 hours and is unlikely to crack after scabbing, the wound is unlikely to infect, and inflammation is little, so that the problem that the surgery injury is hard to heal when the traditional medicine is used for treating the surgery injury at the skin of the movable joint is solved. The medicine is a new medicine with a breakthrough treatment effect; moreover, the formula is simple, safe and free of toxic ingredient.
Description
The technology of the present invention field:
The present invention is the fresh medicine processing technique field of Chinese medicine, is to get medicinal modern biotechnology preservation by low temperature in fresh Herba Agrimoniae (Herba Agrimoniae Latin title: same under Herba Agrimoniae) to be processed into fresh medicine medicated powder.Again fresh medicine medicated powder and lysozyme (Latin title: Lysozyme, lower same) are combined into new pharmaceutical preparation.
Background technology
Traditional concocting method of Herba Agrimoniae Chinese medicine: [process of preparing Chinese medicine] removing undesirable root and impurity, cleans, slightly moistens, cutting, dry.[function with cure mainly] astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances, tonify deficiency.[usage and consumption] 6 ~ 12g.Suitable amount used externally.Smash deposited.{ coming from 2010 editions Chinese Pharmacopoeia aid illustration one (medical material and sheet of admiring) the 158th page }.Because Chinese medicine Preparation process method makes the medicament effective component loss of Herba Agrimoniae large, retain few, make the convergence of Herba Agrimoniae in treatment surgical wound, hemostasis, more creates DeGrain.
Summary of the invention of the present invention
The present invention be the leaf of fresh Chinese medicine Herba Agrimoniae, stem modern biotechnology preservation by low temperature processing after fresh medicine medicated powder and lysozyme be combined into new pharmaceutical preparation.Greatly improve reservation and the application of medicament effective component after fresh Herba Agrimoniae preservation by low temperature processing, the medicine after processing can be directly used in the hemostasis for the treatment of surgical wound wound, convergence, more wound, and antiinflammatory, and instant effect are effective.Add anti-inflammatory (increase antibacterial range) and stability (lysozyme has antisepsis) that accessory drugs lysozyme adds preparation of Chinese medicine.
This preparation is also effective to treatment furuncle redness through normal individual trial.
Technical solution of the present invention:
One, raw material obtains: (this case mentions that fresh Herba Agrimoniae raw material takes from Hunan Province's Ningxiang County and periphery region)
Get fresh hairyvein agrimonia leaf, stem (can solely get or round strain) hereinafter referred to as " fresh Herba Agrimoniae ", first fresh Herba Agrimoniae sterile distilled water is cleaned up rear removal outside moisture (can use and dry device processes), fresh Herba Agrimoniae is sterilized (can also sterilize with the ethanol Quick disinfection of concentration less than 80% or by disinfectant such as mercuric chloride), within 1 hour total time of sterilization with ultraviolet radiation again.
Two, processing method:
1, fresh Herba Agrimoniae is processed into powder (wet-milling that water content is high, hereinafter referred to as " wet-milling ") by fresh Herba Agrimoniae room temperature to the temperature (available liquid nitrogen flash freezer) of-199 DEG C of scopes through cleaning and sterilizing.Wet-milling (or with the fresh Herba Agrimoniae through cleaning and sterilizing), (within 5-8 hour, effect is good to put into the lyophilization of freeze dryer evacuation again, general in 10 hours) make lyophilized powder (dry powder that water content is low, hereinafter referred to as " lyophilized powder ").The wet-milling high because of water content and the low lyophilized powder drug effect difference of water content little, so wet-milling and lyophilized powder are collectively referred to as " the fresh powder of Herba Agrimoniae ".
Another: wet-milling uses freeze dryer lyophilizing after can adding quantitative lysozyme (within 0.05%-0.5%, effect is good, or with concentration within 3%) mixing, just can make freeze-dried powder preparation.
2, by through cleaning and sterilizing fresh Herba Agrimoniae room temperature to the temperature equipment of-199 DEG C of scopes by fresh Herba Agrimoniae fragmentation after extract juice (also can be processed into lyophilized powder hereinafter referred to as " extracting solution " extracting solution).
Three, formulation ingredients and synthetic technology scheme
Formulation ingredients: Herba Agrimoniae fresh powder 97%-99.999%, lysozyme 0.001%-3% (lysozyme 0.05%-0.5% effect is good).
Using two kinds of mixed medicines of composition in this preparation as traumatic wounds medication, can directly with or make patch (common name: adhesive bandage, lower with); Also can add other vaseline of pharmaceutical grade, glue or make preparation with media such as glycerol, or with the vaseline of medicinal rank, the medium such as glue or glycerol makes drug adhesion (or emulsifying) make patch on adhesive plaster (or ribbon); Also other low concentration sodium chloride solution of available pharmaceutical grade (the isotonic solution effect of 0.9% is good, also can by concentration within 9%), water is using medication after the damping of this preparation of Chinese medicine or as preparation.
Medicine after the damping of this preparation can directly with or make patch; Also can add other vaseline of pharmaceutical grade, glue or make preparation with media such as glycerol, or with the vaseline of medicinal rank, the medium such as glue or glycerol makes drug adhesion (or emulsifying) make patch on adhesive plaster (or ribbon).Because fresh red crowned crane grass meal can be directly used in the hemostasis for the treatment of surgical wound wound, convergence, more wound, antiinflammatory, and instant effect, effective; So adding preservative agent, antibiotic medicine just can be combined into preparation.But general antiseptic or antibiotic medicine do not have the anticorrosion of lysozyme and antiinflammatory double effects; And antibiotic medicine and wound surface bond (Typical Representative: sulfonamides), inflammatory phenomena under crust can be formed.Nisin (Latin title: Nisin) solely can add or close with lysozyme and add (safety of Nisin and human body skin internal layer contact tissue under study for action).
Illustrate: the effect by the damping of this preparation of Chinese medicine: the dry powder because of this preparation can absorb traumatic wounds and bleeds and produce condensation phenomenon, by medicine damping, this phenomenon can be alleviated, use wet medicated powder and wound wound surface generally non-caked (or it is few to bond), easily remove from wound surface with medicine later.
Four, the advantage of Herba Agrimoniae fresh medicine preservation by low temperature processing method compared with Chinese medicine Preparation process method:
Herba Agrimoniae fresh medicine preservation by low temperature processing method greatly improves reservation and the application of the active ingredient of Herba Agrimoniae fresh powder Chinese medicine, make the fresh powder of Herba Agrimoniae (wet-milling or lyophilized powder) through preservation by low temperature processing can be directly used in the hemostasis for the treatment of traumatic wounds, convergence, more wound, antiinflammatory, and instant effect, effective.And the hemostasis of the Herba Agrimoniae treated powder traumatic wounds of Chinese medicine Preparation process method processing, convergence, more creates DeGrain, is in dispute.Verify through zoopery: the fresh powder of Herba Agrimoniae is used for the treatment of wound mouth, within medication 2-3 hour, just obviously can observe the receipts sword of wound wound surface, drying effect, haemostatic effect is obvious, wound surface incrustation in 8-12 hour, totally, and general NIP phenomenon.And with Chinese medicine Preparation process method processing Herba Agrimoniae treated powder wound mouth, within 12 hours, all can not observe the receipts sword creating wound surface, drying effect, haemostatic effect is not obvious.
Five, this preparation advantage
1, simple, the safety of this pharmaceutical formulation composition, eliminates the use of toxic substance in the pharmaceutical preparation of traditional treatment traumatic wounds.
2, the complete rear trace of this preparation for treating surgical wound wound is small, the outer wound of skin shallow-layer entirely heal (about 20 days) afterwards scar not easily discover (wound treatment of wounds whole process can not have iodine to remain, iodine is residual can cause wound mouth complete more after trace obvious).
3, this preparation short wound wound surface self healing incrustation, short wound surface is dry, and medicated powder (damping) and wound surface be non-caked (or it is few to bond) generally, easily removes from wound surface with medicine later; Wound surface incrustation in the skin small size surgical wound 12 hours of movable joint place, and crust scar is not easily split, wound mouth not easy infection, inflammation phenomenon under general NIP and crust, well solves the difficult point of traditional traumatic wounds Drug therapy joint skin surgery the wound refused to heal.It is a kind of new drug with breakthrough therapeutic effect.
4, two kinds of antimicrobial factorses combine, and reach broad-spectrum antiseptic anti-inflammatory effect.
5, indicate: available (water preparation, composition the 6th describes in detail), as traumatic wounds process, as debridement, stops blooding; Use after traumatic wounds scabs.(water preparation) is as the composite reagent (treatment of wounds) of this preparation; Because (water preparation) is raw materials used the same with this preparation, the property of medicine is close, makes the trace of this preparation little, and the feature that bond with wound surface more obviously (and easily cause iodine residual with povidone iodine process wound, it is obvious that iodine remains meeting trace).(water preparation) and traditional vulnerary with the use of, its feature is difficult to embody separately.(water preparation) can divisional application by Patent Law detailed rules for the implementation 34 and 42 requirements.
6, (water preparation composition): fresh Herba Agrimoniae extracting solution 1%-99.999%, lysozyme 0.001%-3% (lysozyme 0.05%-0.5% effect is good), distilled water 0%-99% (it is good that the sodium chloride that can add 0.9% makes isotonic solution effect, also can by concentration within 9%).
Illustrate: this preparation tests medication in person through the present invention first, second inventor, sums up above advantage in conjunction with zoopery.
Six, preparation explanation
The fresh powder of Herba Agrimoniae: hemostasis, convergence, more wound, antiinflammatory.
Lysozyme: antiinflammatory, sterilization, fresh-keeping.
This preparation be with the fresh powder of Chinese medicine Herba Agrimoniae for principal agent, add lysozyme mixing after, enhance anti-inflammatory (increase antibacterial range) and the stability (lysozyme has antisepsis) of preparation of Chinese medicine; The fresh powder of Herba Agrimoniae because of store and processing wants cold storing and fresh-keeping or freezen protective to ensure the stability of medicine, adds the fresh-keeping fresh powder stability of Herba Agrimoniae that makes of lysozyme and is strengthened.
This preparation:
[function cures mainly] stops blooding, antiinflammatory, convergence, more wound.
[usage and dosage] diameter 1.5 centimetres of surgical wound models medication 80 milligrams; Suitable amount used externally.
The fresh powder of [pharmacological toxicology] Herba Agrimoniae has anastalsis, has astriction tool antiinflammatory action simultaneously, therefore have wound mouth and more create use in the fresh powder of Herba Agrimoniae containing Herba Agrimoniae tannin; The fresh powder of Herba Agrimoniae has inhibitory action to gram-negative bacteria; Lysozyme is a kind of mucopolysaccharide hydrolytic enzyme of extensively distribution in human body, can be liquefied the insoluble polysaccharide of Gram-positive cell wall, being hydrolyzed into solubility mucopeptide, is a kind of natural infection material of tool bactericidal action, has the effect of antibacterial, antiviral, antiinflammatory, quickening organized renewing.
Should not carry out motion and the work of high strength during [points for attention] medication, avoid sweat flow into wound wound surface and cause wound inflammation, phenomenon of suppurating, the particularly first 3 day period of topical agent.As wound surface inflammation is suppurated, pus shape thing is removed the drug of topical application again totally from wound surface by available water preparation.Also can with erythromycin ointment or other disinfectant process, after process the most handy normal saline (0.9% sodium chloride solution) washing wound surface is clean after the drug of topical application again.During process wound, its wound surface iodine of having tried not remains, iodine is residual can cause wound mouth complete more after trace obvious.
Points for attention illustrate: this preparation was tried out in person by the present invention first, second inventor, and have many people to try out voluntarily in the He Batang township of Zi Fu township of Hunan Province's Ningxiang County, separately have many people to try out under the guidance of Zhou Liqing doctor, effect is fine.The therapeutic effect of the present invention first inventor to person on probation draws above-mentioned points for attention after observing and visiting, and is observing and is not finding untoward reaction after visiting and investigating.This preparation, after carrying out 20 routine wounds in animals model experiments, does not observe untoward reaction.
[zoopery]
Results of animal shows: with after the fresh powder of the Herba Agrimoniae adding lysozyme and the Herba Agrimoniae fresh powder process wound mouth not adding lysozyme, wound wound healing effect is substantially identical, and Herba Agrimoniae fresh powder lyophilized powder is identical with the Herba Agrimoniae of non-lyophilizing fresh powder healing effect.(3 days) wound speed of wound healing and astriction are obviously better than YUNNAN BAIYAO processed group, cured leaf powder group and blank group in early days, and wound surface is done, NIP phenomenon; Mechanical damage area is 1.77cm
2the wound of (diameter 1.5cm) can heal (seeing the following form) completely in 9-12 days, was obviously better than blank group, was slightly better than YUNNAN BAIYAO group.Compared with YUNNAN BAIYAO processed group, wound mouth healing skin after the process of Herba Agrimoniae fresh powder is consistent with original skin color, healing place cicatrix obviously diminishes and in fine streaks (because being that epiderm skin heals from wound surface surrounding toward pushed with the wound healing after the fresh powder process of Herba Agrimoniae, YUNNAN BAIYAO is that whole wound surface recovers together, the epiderm skin healing process of two kinds of medicines, mode is different), YUNNAN BAIYAO healing place trace is obvious and rounded (identical with the wound surface size and shape of wound mouth).
Rat trauma model experimental result (the fresh powder of Herba Agrimoniae adds lysozyme group, this group lysozyme content 0.1%)
Claims (1)
1. the present invention gets fresh Herba Agrimoniae Chinese medicine (Herba Agrimoniae Latin title: same under Herba Agrimoniae), new pharmaceutical preparation is combined into the medicated powder after the processing of modern biotechnology preservation by low temperature and lysozyme (Latin title: Lysozyme, lower same).
Technical solution of the present invention:
One, raw material obtains: (this case mentions that fresh Herba Agrimoniae raw material takes from Hunan Province's Ningxiang County and periphery region)
Get fresh hairyvein agrimonia leaf, stem (can solely get or round strain) hereinafter referred to as " fresh Herba Agrimoniae ", first fresh Herba Agrimoniae sterile distilled water is cleaned up rear removal outside moisture (can use and dry device processes), fresh Herba Agrimoniae is sterilized (can also sterilize with the ethanol Quick disinfection of concentration less than 80% or by disinfectant such as mercuric chloride), within 1 hour total time of sterilization with ultraviolet radiation again.
Two, processing method:
1, fresh Herba Agrimoniae is processed into powder (wet-milling that water content is high, hereinafter referred to as " wet-milling ") by fresh Herba Agrimoniae room temperature to the temperature (available liquid nitrogen flash freezer) of-199 DEG C of scopes through cleaning and sterilizing.Wet-milling (or with the fresh Herba Agrimoniae through cleaning and sterilizing), (within 5-8 hour, effect is good to put into the lyophilization of freeze dryer evacuation again, general in 10 hours) make lyophilized powder (dry powder that water content is low, hereinafter referred to as " lyophilized powder ").The wet-milling high because of water content and the low lyophilized powder drug effect difference of water content little, so wet-milling and lyophilized powder are collectively referred to as " the fresh powder of Herba Agrimoniae ".
Another: wet-milling uses freeze dryer lyophilizing after can adding quantitative lysozyme (within 0.05%-0.5%, effect is good, or with concentration within 3%) mixing, just can make freeze-dried powder preparation.
2, by through cleaning and sterilizing fresh Herba Agrimoniae room temperature to the temperature equipment of-199 DEG C of scopes by fresh Herba Agrimoniae fragmentation after extract juice (also can be processed into lyophilized powder hereinafter referred to as " extracting solution " extracting solution).
Three, formulation ingredients and synthetic technology scheme
Formulation ingredients: Herba Agrimoniae fresh powder 97%-99.999%, lysozyme 0.001%-3% (lysozyme 0.05%-0.5% effect is good).
Using two kinds of mixed medicines of composition in this preparation as traumatic wounds medication, can directly with or make patch (common name: adhesive bandage, lower with); Also can add other vaseline of pharmaceutical grade, glue or make preparation with media such as glycerol, or with the vaseline of medicinal rank, the medium such as glue or glycerol makes drug adhesion (or emulsifying) make patch on adhesive plaster (or ribbon); Also other low concentration sodium chloride solution of available pharmaceutical grade (the isotonic solution effect of 0.9% is good, also can by concentration within 9%), water is using medication after the damping of this preparation of Chinese medicine or as preparation.
Medicine after the damping of this preparation can directly with or make patch; Also can add other vaseline of pharmaceutical grade, glue or make preparation with media such as glycerol, or with the vaseline of medicinal rank, the medium such as glue or glycerol makes drug adhesion (or emulsifying) make patch on adhesive plaster (or ribbon).Because fresh red crowned crane grass meal can be directly used in the hemostasis for the treatment of surgical wound wound, convergence, more wound, antiinflammatory, and instant effect, effective; So adding preservative agent, antibiotic medicine just can be combined into preparation.But general antiseptic or antibiotic medicine do not have the anticorrosion of lysozyme and antiinflammatory double effects; And antibiotic medicine and wound surface bond (Typical Representative: sulfonamides), inflammatory phenomena under crust can be formed.Nisin (Latin title: Nisin) solely can add or close with lysozyme and add (safety of Nisin and human body skin internal layer contact tissue under study for action).
Illustrate: the effect by the damping of this preparation of Chinese medicine: the dry powder because of this preparation can absorb traumatic wounds and bleeds and produce condensation phenomenon, by medicine damping, this phenomenon can be alleviated, use wet medicated powder and wound wound surface generally non-caked (or it is few to bond), easily remove from wound surface with medicine later.
Four, the advantage of Herba Agrimoniae fresh medicine preservation by low temperature processing method compared with Chinese medicine Preparation process method:
Herba Agrimoniae fresh medicine preservation by low temperature processing method greatly improves reservation and the application of the active ingredient of Herba Agrimoniae fresh powder Chinese medicine, make the fresh powder of Herba Agrimoniae (wet-milling or lyophilized powder) through preservation by low temperature processing can be directly used in the hemostasis for the treatment of traumatic wounds, convergence, more wound, antiinflammatory, and instant effect, effective.And the hemostasis of the Herba Agrimoniae treated powder traumatic wounds of Chinese medicine Preparation process method processing, convergence, more creates DeGrain, is in dispute.Verify through zoopery: the fresh powder of Herba Agrimoniae is used for the treatment of wound mouth, within medication 2-3 hour, just obviously can observe the receipts sword of wound wound surface, drying effect, haemostatic effect is obvious, wound surface incrustation in 8-12 hour, totally, and general NIP phenomenon.And with Chinese medicine Preparation process method processing Herba Agrimoniae treated powder wound mouth, within 12 hours, all can not observe the receipts sword creating wound surface, drying effect, haemostatic effect is not obvious.
Five, this preparation advantage
1, simple, the safety of this pharmaceutical formulation composition, eliminates the use of toxic substance in the pharmaceutical preparation of traditional treatment traumatic wounds.
2, the complete rear trace of this preparation for treating surgical wound wound is small, the outer wound of skin shallow-layer entirely heal (about 20 days) afterwards scar not easily discover (wound treatment of wounds whole process can not have iodine to remain, iodine is residual can cause wound mouth complete more after trace obvious).
3, this preparation short wound wound surface self healing incrustation, short wound surface is dry, and medicated powder (damping) and wound surface be non-caked (or it is few to bond) generally, easily removes from wound surface with medicine later; Wound surface incrustation in the skin small size surgical wound 12 hours of movable joint place, and crust scar is not easily split, wound mouth not easy infection, inflammation phenomenon under general NIP and crust, well solves the difficult point of traditional traumatic wounds Drug therapy joint skin surgery the wound refused to heal.It is a kind of new drug with breakthrough therapeutic effect.
4, two kinds of antimicrobial factorses combine, and reach broad-spectrum antiseptic anti-inflammatory effect.
5, indicate: available (water preparation, composition the 6th describes in detail), as traumatic wounds process, as debridement, stops blooding; Use after traumatic wounds scabs.(water preparation) is as the composite reagent (treatment of wounds) of this preparation; Because (water preparation) is raw materials used the same with this preparation, the property of medicine is close, makes the trace of this preparation little, and the feature that bond with wound surface more obviously (and easily cause iodine residual with povidone iodine process wound, it is obvious that iodine remains meeting trace).(water preparation) and traditional vulnerary with the use of, its feature is difficult to embody separately.(water preparation) can divisional application by Patent Law detailed rules for the implementation 34 and 42 requirements.
6, (water preparation composition): fresh Herba Agrimoniae extracting solution 1%-99.999%, lysozyme 0.001%-3% (lysozyme 0.05%-0.5% effect is good), distilled water 0%-99% (it is good that the sodium chloride that can add 0.9% makes isotonic solution effect, also can by concentration within 9%).
Illustrate: this preparation tests medication in person through the present invention first, second inventor, sums up above advantage in conjunction with zoopery.
Six, preparation explanation
The fresh powder of Herba Agrimoniae: hemostasis, convergence, more wound, antiinflammatory.
Lysozyme: antiinflammatory, sterilization, fresh-keeping.
This preparation be with the fresh powder of Chinese medicine Herba Agrimoniae for principal agent, add lysozyme mixing after, enhance anti-inflammatory (increase antibacterial range) and the stability (lysozyme has antisepsis) of preparation of Chinese medicine; The fresh powder of Herba Agrimoniae because of store and processing wants cold storing and fresh-keeping or freezen protective to ensure the stability of medicine, adds the fresh-keeping fresh powder stability of Herba Agrimoniae that makes of lysozyme and is strengthened.
This preparation [function cures mainly] stops blooding, antiinflammatory, convergence, more wound.
Seven, the scope of request protection
1, the fresh powder 97%-99.999% of Herba Agrimoniae, lysozyme 0.001%-3%, is combined into preparation.
2, with: the fresh powder 97%-99.999% of Herba Agrimoniae, lysozyme 0.001%-3%, be combined into preparation for principal agent adds other adjuvant (as other vaseline of pharmaceutical grade, glue, glycerol, water, low concentration sodium chloride solution, adhesive plaster etc.).
3, with the fresh powder 97%-99.999% of Herba Agrimoniae, lysozyme 0.001%-3%, for principal agent add other adjuvant (as other vaseline of pharmaceutical grade, glue, glycerol, water, low concentration sodium chloride solution, adhesive plaster, antibiotic medicine, other type antiseptic etc.) be combined into preparation.
4, the fresh powder 94%-99.999% of Herba Agrimoniae, singly adds nisin (Latin title: Nisin) 0.001%-3% or share with lysozyme 0.001%-3%; Other adjuvant (as other vaseline of pharmaceutical grade, glue, glycerol, water, low concentration sodium chloride solution, adhesive plaster etc.) can be added and be combined into preparation.
5, the fresh powder of Herba Agrimoniae adds the antiseptic of other type, antibiotic medicine; Other adjuvant (as other vaseline of pharmaceutical grade, glue, glycerol, water, low concentration sodium chloride solution, adhesive plaster etc.) can be added and be combined into preparation.
6, the fresh powder of Herba Agrimoniae adds adjuvant (as other vaseline of pharmaceutical grade, glue, glycerol, water, low concentration sodium chloride solution, adhesive plaster etc.) and is combined into preparation.
7, the fresh powder of Herba Agrimoniae is as pharmaceutical preparation.
8, can the water preparation of divisional application with fresh Herba Agrimoniae extracting solution 1%-99.999%, lysozyme 0.001%-3% (the antiseptic of other type available or alone, antibiotic medicine), sterile distilled water 0%-99%, (within can adding low concentration sodium chloride 0.9% or 9%) is combined into preparation.
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| CN201410658121.5A CN104474536A (en) | 2014-11-19 | 2014-11-19 | Fresh agrimonia pilosa medicine preparation for treating wounds |
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Cited By (4)
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| CN105963761A (en) * | 2016-05-11 | 2016-09-28 | 山东司邦得制药有限公司 | Lysozyme hydrochloride band-aid and making method and application thereof |
| CN106362203A (en) * | 2016-11-23 | 2017-02-01 | 遵义医学院 | Manufacturing method of smearing type band-aid |
| CN108272882A (en) * | 2018-04-02 | 2018-07-13 | 浙江沃野神生物科技有限公司 | A kind of preparation method of Smallfruit Rose Root freeze dried powder |
| CN112353937A (en) * | 2020-12-03 | 2021-02-12 | 周清华 | Fresh agrimony freeze-dried powder composite preparation |
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| CN103271794A (en) * | 2013-06-17 | 2013-09-04 | 上海微纳科技有限公司 | Biological antibacterial patch for bedsore surface |
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| CN103271794A (en) * | 2013-06-17 | 2013-09-04 | 上海微纳科技有限公司 | Biological antibacterial patch for bedsore surface |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963761A (en) * | 2016-05-11 | 2016-09-28 | 山东司邦得制药有限公司 | Lysozyme hydrochloride band-aid and making method and application thereof |
| CN105963761B (en) * | 2016-05-11 | 2019-03-22 | 山东司邦得制药有限公司 | A kind of lisozima adhesive bandage and its preparation method and application |
| CN106362203A (en) * | 2016-11-23 | 2017-02-01 | 遵义医学院 | Manufacturing method of smearing type band-aid |
| CN108272882A (en) * | 2018-04-02 | 2018-07-13 | 浙江沃野神生物科技有限公司 | A kind of preparation method of Smallfruit Rose Root freeze dried powder |
| CN112353937A (en) * | 2020-12-03 | 2021-02-12 | 周清华 | Fresh agrimony freeze-dried powder composite preparation |
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