CN107468639A - A kind of gynaecologic antibiotic gel and preparation method thereof - Google Patents
A kind of gynaecologic antibiotic gel and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of gynaecologic antibiotic gel, Notogineng Extract, aloe extract, safflower extract, houttuynia extract, isatis root extract, Nano Silver, antibacterial peptide, polyethylene glycol, gel-type vehicle and deionized water.A kind of gynaecologic antibiotic gel proposed by the present invention, using Plant Extracts as main antiseptic, while Nano Silver and antibacterial peptide are also added, a variety of antimicrobial components have synergy so that this product has broad-spectrum antibacterial action, and rapid-action, safety has no side effect；In addition antibacterial peptide is while bacterium is killed, additionally it is possible to improves immunity of organisms, helps the invasion and attack of human body resistance foreign pathogen.It the experiment proved that, antiseptic produced by the present invention by Escherichia coli, Candida albicans, staphylococcus aureus and Pseudomonas aeruginosa to having significant inhibitory action；98.2% is up to the cure rate of vaginitis.
Description
Technical field
The present invention relates to daily chemical product technical field, more particularly to a kind of gynaecologic antibiotic gel and preparation method thereof.
Background technology
Gynecological disease has a strong impact on the health of women, according to statistics, has 40% or so in China adult women crowd
People is often subject to the puzzlement of various gynecological diseases, suffers untold misery.Gynecological disease includes vaginitis, cervicitis, pruritus vulvue, peculiar smell
Deng it is primarily due to the influence of the factors such as the physiological structure of women, living environment, makes women easily by white
The invasion and attack of the pathogen such as candida albicans, staphylococcus aureus, streptococcus, Escherichia coli, virus；There are some patientss to be protected due to self
Shield consciousness is weak, is paid little attention in the early stage being infected, and can cause more serious infection；Additionally due to bad habits and customs
Or operating pressure is larger, makes some patientss immunity poor, cause gynecological disease obstinate, brought greatly to normal life
Inconvenience.
At present, it is various to treat the antibacterials species of gynaecological imflammation, is broadly divided into suppository class, lotion class, spray class etc., but
Most drug can produce destruction to genital tract environment, mucous membrane itself secreting function, so as to cause under reproduction local immunity
Drop, and cause pathogenic bacteria to develop immunity to drugs and drug resistance, final inflammation recurrent exerbation；In addition also there is antibacterial species in some drugs
The defects of single, slowly effect, how to solve above-mentioned technical deficiency, turn into urgent problem to be solved.
The content of the invention
Based on technical problem existing for background technology, the present invention, which proposes, provides a kind of gynaecologic antibiotic gel, has good
Antibacterial effect.
A kind of gynaecologic antibiotic gel, including following component in parts by weight：Notogineng Extract 0.5-1.2 parts, aloe
Extract 0.2-0.7 parts, safflower extract 0.2-0.7 parts, Nano Silver 0.1-0.3 parts, antibacterial peptide 0.7-1.3 parts, polyethylene glycol
1.2-1.6 parts, gel-type vehicle 1-2 parts, deionized water 60-70 parts.
Preferably, the component of following parts by weight meter is included：Houttuynia extract 0.3-0.6 parts.
Preferably, the component of following parts by weight meter is included：Isatis root extract 0.2-0.7 parts.
Preferably, the antibacterial peptide includes Magainin and alexin.
Preferably, the quality adding proportion of the Magainin and alexin is 1：(3-6).
Preferably, the gel-type vehicle is sodium alginate, hyaluronic acid or xanthans.
A kind of preparation method of gynaecologic antibiotic gel, method and step are as follows：S1：Each Plant Extracts are added into deionization
In water, 50-60min is stirred at 45-55 DEG C；S2：After the mixed solution obtained by S1 is down to room temperature, adds Nano Silver, coagulate
Gel matrix, stir 30-40min；S3：Antibacterial peptide, polyethylene glycol are added into mixed solution made from S2, stirs 10min, i.e.,
.
Further, the mixing speed of the S1 is 400-500rpm；The mixing speed of the S2 and S3 are 100-
150rpm。
A kind of composition proposed by the present invention is applied to prepare gynaecologic antibiotic gel.
Feature component：
Active ingredient in Notogineng Extract is ginsenoside, and contains the compounds such as flavonoid glycoside, dencichine, flavones；
Research has shown that Notogineng Extract have to external Pseudomonas aeruginosa, staphylococcus aureus and beta streptococcus it is obvious antibacterial
Effect.
Contain anthraquinone analog compound, polysaccharide, organic acid, amino acid, vitamin, mineral matter element, work in aloe extract
Property enzyme, etc. plurality of active ingredients.The bactericidal action of aloe and the function phase of antibiotic are same, and have the work(not available for antibiotic
Can, the endotoxin that thalline leaves after toxic metabolite and bacterium are killed caused by energy bacteria removal infection.Research finds, reed
Anthraquinone analog compound in luxuriant growth has the effects such as sterilization, antibacterial, anti-inflammatory, removing toxic substances, promotion wound healing mostly, is used clinically for
Inflammation is treated, it is evident in efficacy；Tinctura aloes is the very strong material of antibiotic property, has and bacterium, virus, fungi, mould are resisted
Bacterium bactericidal action, can suppress the development breeding of pathogeny body, and not produce drug resistance bacterium in use, also not produce bacterium
Alternate Phenomenon, moreover it is possible to effectively kill because using antibiotic and caused by drug-fast bacteria；Polysaccharide in aloe can effectively strengthen
The resistance of human body, particularly strengthen anti-inflammation and sterilization ability.
Contain carthamin, neocarthamin and safflower quinone glucoside, nonacosane B- sitosterol, palmitic acid, meat in safflower extract
Myristic acid, laurate, glycerol-1,3-dipalmitate, oleic acid, linoleic acid, B- sitosterol -3-O- glycosides, polysaccharide etc.；Through research
Show, safflower extract is to Escherichia coli, bacillus subtilis, staphylococcus aureus, sarcine and pseudomonas aeruginosa
There is obvious inhibitory action.
Containing volatile oil, afzelin, hyperin and cordarine etc. in houttuynia extract；The main component of volatile oil has
Decanoyl acetaldehyde, methylnonanone, laurene, certain herbaceous plants with big flowers aldehyde；Flavones ingredient has quercetin, dry measure used in former times skin glycosides, rutin etc., wherein with caprinoyl second
The content highest of aldehyde；Decanoyl acetaldehyde is decanoy acetaldehyde, modern pharmacology experiment prove decanoy acetaldehyde have antibacterial, antiviral, anti-inflammatory,
Antiallergy, antitumor, diuresis, can also strengthen body's immunity.Cordate houttuynia is to streptococcus, staphylococcus aureus, stream
Sense bacillus, micrococcus catarrhalis, pneumococcus have obvious inhibitory action；Also there is work to Escherichia coli, shigella dysenteriae, typhoid bacillus
With.
Contain indigo, indigo red, Anthraquinones, cupreol, clionasterol and a variety of ammonia containing root in isatis root extract
Base acid；Radix Isatidis has effect to various bacteria, such as hay bacillus, staphylococcus aureus, sarcine, Escherichia coli, typhoid fever
Bacillus, paratyphoid A bacillus, dysentery (will Hayes, Freund) bacillus, bacillus enteritidis etc..
Nano Silver：Nano-Ag particles are directly entered thalline and combined with oxygen metabolism enzyme (- SH), the uniqueness for making thalline be choked to death
Mechanism of action, the microorganisms such as the most of bacteriums being in contact with it, fungi, mould, spore can be killed.It is for example resistance to pathogenic bacteria of drug-resistant
Medicine Escherichia coli, resistance golden staphylococci, drug-resistant pseudomonas aeruginosa, streptococcus pyogenes, resistance enterococcus, anaerobic bacteria etc. have comprehensively
Antibacterial activity；The bacterium common to burn and scald and wound surface such as staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, white
Candida albicans and other G+, G- pathogenic bacteria have bactericidal action；To chlamydia trachomatis, cause the gonococcus of sexually transmitted disease
There is powerful bactericidal action.
The killing that antibacterial peptide is referred to as " natural antibiotic " and has high-efficiency broad spectrum to Gram-negative and positive bacteria is made
With antibacterial peptide can directly destroy cell membrane, kill germ；It can be expressed with controlling gene, kill virus；In addition antibacterial peptide can also
Immunity is improved, resists disease and infection.
Compared with prior art, the device have the advantages that being：
A kind of gynaecologic antibiotic gel proposed by the present invention, using Plant Extracts as main antiseptic, it also added simultaneously
Nano Silver and antibacterial peptide, a variety of antimicrobial components have synergy so that and this product has a broad-spectrum antibacterial action, and rapid-action,
Safety has no side effect；In addition antibacterial peptide is while bacterium is killed, additionally it is possible to improves immunity of organisms, helps human body resistance external
The invasion and attack of pathogen.It the experiment proved that, antiseptic produced by the present invention is to by Escherichia coli, Candida albicans, golden yellow grape
Coccus and Pseudomonas aeruginosa have significant inhibitory action；98.2% is up to the cure rate of vaginitis.
Embodiment
The present invention is made with reference to specific embodiment further to explain.
Embodiment 1
A kind of gynaecologic antibiotic gel, including following component in parts by weight：0.5 part of Notogineng Extract, aloe extraction
0.2 part of thing, 0.2 part of safflower extract, 0.3 part of houttuynia extract, 0.2 part of isatis root extract, 0.1 part of Nano Silver, antibacterial
0.7 part of peptide, 1.2 parts of polyethylene glycol, 1 part of gel-type vehicle, 60 parts of deionized water.
The quality adding proportion of Magainin and alexin is 1 in antibacterial peptide：3；Gel-type vehicle is sodium alginate.
A kind of preparation method of gynaecologic antibiotic gel, method and step are as follows：S1：Each Plant Extracts are added into deionization
In water, 50min, mixing speed 400rpm are stirred at 45 DEG C；S2：After the mixed solution obtained by S1 is down to room temperature, add
Enter Nano Silver, gel-type vehicle, stir 30min, mixing speed is 100rpm；S3：Added into mixed solution made from S2 anti-
Bacterium peptide, polyethylene glycol, 10min is stirred, mixing speed is 100rpm, is produced.
Embodiment 2
A kind of gynaecologic antibiotic gel, including following component in parts by weight：1.2 parts of Notogineng Extract, aloe extraction
0.7 part of thing, 0.7 part of safflower extract, 0.6 part of houttuynia extract, 0.7 part of isatis root extract, 0.3 part of Nano Silver, antibacterial
1.3 parts of peptide, 1.6 parts of polyethylene glycol, 2 parts of gel-type vehicle, 70 parts of deionized water.
The quality adding proportion of Magainin and alexin is 1 in antibacterial peptide：6；Gel-type vehicle is hyaluronic acid.
A kind of preparation method of gynaecologic antibiotic gel, method and step are as follows：S1：Each Plant Extracts are added into deionization
In water, 60min, mixing speed 500rpm are stirred at 55 DEG C；S2：After the mixed solution obtained by S1 is down to room temperature, add
Enter Nano Silver, gel-type vehicle, stir 40min, mixing speed is 150rpm；S3：Added into mixed solution made from S2 anti-
Bacterium peptide, polyethylene glycol, 10min is stirred, mixing speed is 150rpm, is produced.
Embodiment 3
A kind of gynaecologic antibiotic gel, including following component in parts by weight：1.1 parts of Notogineng Extract, aloe extraction
0.5 part of thing, 0.4 part of safflower extract, 0.5 part of houttuynia extract, 0.6 part of isatis root extract, 0.2 part of Nano Silver, antibacterial
1.0 parts of peptide, 1.4 parts of polyethylene glycol, 1.5 parts of gel-type vehicle, 65 parts of deionized water.
The quality adding proportion of Magainin and alexin is 1 in antibacterial peptide：4；Gel-type vehicle is xanthans.
A kind of preparation method of gynaecologic antibiotic gel, method and step are as follows：S1：Each Plant Extracts are added into deionization
In water, 57min, mixing speed 450rpm are stirred at 50 DEG C；S2：After the mixed solution obtained by S1 is down to room temperature, add
Enter Nano Silver, gel-type vehicle, stir 32min, mixing speed is 110rpm；S3：Added into mixed solution made from S2 anti-
Bacterium peptide, polyethylene glycol, 10min is stirred, mixing speed is 140rpm, is produced.
Embodiment 4
A kind of gynaecologic antibiotic gel, including following component in parts by weight：0.6 part of Notogineng Extract, aloe extraction
0.3 part of thing, 0.3 part of safflower extract, 0.4 part of houttuynia extract, 0.3 part of isatis root extract, 0.1 part of Nano Silver, antibacterial
0.8 part of peptide, 1.3 parts of polyethylene glycol, 1.2 parts of gel-type vehicle, 63 parts of deionized water.
The quality adding proportion of Magainin and alexin is 1 in antibacterial peptide：5；Gel-type vehicle is sodium alginate.
A kind of preparation method of gynaecologic antibiotic gel, method and step are as follows：S1：Each Plant Extracts are added into deionization
In water, 55min, mixing speed 420rpm are stirred at 47 DEG C；S2：After the mixed solution obtained by S1 is down to room temperature, add
Enter Nano Silver, gel-type vehicle, stir 38min, mixing speed is 120rpm；S3：Added into mixed solution made from S2 anti-
Bacterium peptide, polyethylene glycol, 10min is stirred, mixing speed is 130rpm, is produced.
Embodiment 5
A kind of gynaecologic antibiotic gel, including following component in parts by weight：0.8 part of Notogineng Extract, aloe extraction
0.6 part of thing, 0.5 part of safflower extract, 0.5 part of houttuynia extract, 0.4 part of isatis root extract, 0.3 part of Nano Silver, antibacterial
1.2 parts of peptide, 1.5 parts of polyethylene glycol, 1.7 parts of gel-type vehicle, 68 parts of deionized water.
The quality adding proportion of Magainin and alexin is 1 in antibacterial peptide：6；Gel-type vehicle is xanthans.
A kind of preparation method of gynaecologic antibiotic gel, method and step are as follows：S1：Each Plant Extracts are added into deionization
In water, 53min, mixing speed 490rpm are stirred at 52 DEG C；S2：After the mixed solution obtained by S1 is down to room temperature, add
Enter Nano Silver, gel-type vehicle, stir 35min, mixing speed is 130rpm；S3：Added into mixed solution made from S2 anti-
Bacterium peptide, polyethylene glycol, 10min is stirred, mixing speed is 110rpm, is produced.
Properties of product detect
First, sterile test
1st, experimental method：From antibacterial gel made from the embodiment of the present invention 3 to Escherichia coli, staphylococcus aureus,
The sterilizing rate of Candida albicans, Pseudomonas aeruginosa under different action times.Sterilization rate and experiment agents useful for same reference《Disinfection technology
Specification》(version in 2002), experiment is repeated 3 times.
2nd, testing result：It is shown in Table 1.
1 antibacterial test result of table
Conclusion：From table 1, antiseptic produced by the present invention is to by Escherichia coli, Candida albicans, Staphylococcus aureus
Bacterium and Pseudomonas aeruginosa have significant inhibitory action.
2nd, clinical test
1st, subjects：To 170 vaginitis patients using random packet, wherein 110 are to verify treatment group, another 60
For positive controls；Comparison medicine is JIEERYIN XIYE.
2nd, the age：In 170：Treatment group's minimal ages 22 years old, max age 45 years old are average 32.6 years old；Control group is minimum
23 years old age, max age 46 years old are average 34.1 years old.
3rd, the course of disease is distributed：In 170：Treatment group is most short 3 months, most long 24 months；Control group is most short 3 months, most long by 20
Individual month.
4th, observation and treatment method
(1) treatment group：Antibacterial gel made from medicine of the present invention, one time a day, using preceding cleaning private parts, this product one is taken, is removed
Propeller block is gone, propeller is put into intravaginal (3-5cm depths), liquid is disposably injected and guides to depths, takes out and promotes
Device abandons it.
(2) control group：JIEERYIN XIYE, one time a day.
(3) treatment time：14 days.
5th, criterion：
(1) it is effective：Inflammation disappears, and vagina cleanness degree is I degree.
(2) effectively：Symptom mitigation, vagina cleanness degree are II degree.
(3) it is invalid, without significant change after use.
6th, treatment results：It is shown in Table 2.
The treatment results of table 2
| Group | Number | It is effective | Effectively | It is invalid | Total effective rate |
| Treatment group | 110 | 66 | 42 | 2 | 98.2% |
| Control group | 60 | 15 | 38 | 7 | 89.3% |
Table 1 shows：In treatment group 110, effective above person is 108, accounts for 98.2%；In control group, effective above person
For 53.Two groups are compared P<0.01 has significant difference, the results showed that treatment group's positive effect is more than control group.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (9)
1. a kind of gynaecologic antibiotic gel, it is characterised in that including following component in parts by weight：Notogineng Extract 0.5-
1.2 parts, aloe extract 0.2-0.7 parts, safflower extract 0.2-0.7 parts, Nano Silver 0.1-0.3 parts, antibacterial peptide 0.7-1.3
Part, polyethylene glycol 1.2-1.6 parts, gel-type vehicle 1-2 parts, deionized water 60-70 parts.
2. a kind of gynaecologic antibiotic gel according to claim 1, it is characterised in that also include the group of following parts by weight meter
Part：Houttuynia extract 0.3-0.6 parts.
3. a kind of gynaecologic antibiotic gel according to claim 1, it is characterised in that also include the group of following parts by weight meter
Part：Isatis root extract 0.2-0.7 parts.
4. a kind of gynaecologic antibiotic gel according to claim 1, it is characterised in that the antibacterial peptide includes Magainin and prevented
Imperial element.
A kind of 5. gynaecologic antibiotic gel according to claim 5, it is characterised in that the quality of the Magainin and alexin
Adding proportion is 1：(3-6).
A kind of 6. gynaecologic antibiotic gel according to claim 1, it is characterised in that the gel-type vehicle be sodium alginate,
Hyaluronic acid or xanthans.
7. the preparation method of a kind of gynaecologic antibiotic gel according to claim any one of 1-6, it is characterised in that method walks
It is rapid as follows：S1：Each Plant Extracts are added in deionized water, 50-60min is stirred at 45-55 DEG C；S2：Treat that S1 is made
After the mixed solution obtained is down to room temperature, Nano Silver, gel-type vehicle are added, stirs 30-40min；S3：To mixed solution made from S2
Middle addition antibacterial peptide, polyethylene glycol, stir 10min, produce.
A kind of 8. preparation method of gynaecologic antibiotic gel according to claim 7, it is characterised in that the stirring speed of the S1
Spend for 400-500rpm；The mixing speed of the S2 and S3 are 100-150rpm.
9. the composition described in claim any one of 1-6 is applied to prepare gynaecologic antibiotic gel.
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Cited By (6)
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| CN107952022A (en) * | 2017-12-19 | 2018-04-24 | 杨平芝 | A kind of silver ion gynaecological antibacterial gel |
| CN109821006A (en) * | 2019-04-15 | 2019-05-31 | 官成金 | A kind of toxin expelling gel and preparation method thereof for private parts |
| CN111228458A (en) * | 2020-03-24 | 2020-06-05 | 大连富勒烯药业有限公司 | External biological preparation for preventing and treating colpitis and preparation method thereof |
| CN111450176A (en) * | 2019-01-18 | 2020-07-28 | 上海德上生物医药科技有限公司 | Gynecological antibacterial gel |
| CN111840516A (en) * | 2020-09-07 | 2020-10-30 | 黑龙江中医药大学 | Antibacterial gel for gynecology and preparation method thereof |
| CN113855749A (en) * | 2021-11-16 | 2021-12-31 | 林潘海 | Antiviral water condensation bead |
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| CN107952022A (en) * | 2017-12-19 | 2018-04-24 | 杨平芝 | A kind of silver ion gynaecological antibacterial gel |
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Application publication date: 20171215 |