CN101422484A - Nano silver wound-protection anti-inflammation liquid and preparation method thereof - Google Patents
Nano silver wound-protection anti-inflammation liquid and preparation method thereof Download PDFInfo
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- CN101422484A CN101422484A CNA2008102357573A CN200810235757A CN101422484A CN 101422484 A CN101422484 A CN 101422484A CN A2008102357573 A CNA2008102357573 A CN A2008102357573A CN 200810235757 A CN200810235757 A CN 200810235757A CN 101422484 A CN101422484 A CN 101422484A
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Abstract
The invention discloses a nano-silver wound-protection antiphlogistic liquid and a preparation method thereof. The antiphlogistic liquid contains the following components according to weight proportions: 0.06 to 0.12 percent of AgNO3; 0.09 to 0.30 percent of droxyethylcellulose; 0.10 to 0.40 percent of osmotic agent; 1.0 to 4.0 percent of antifoaming agent and the rest is deionized purified water. The preparation method is s follows: 1) the droxyethylcellulose is added into the deionized purified water, stirred and heated to obtain a liquid A; 2) the AgNO3 is added into the deionized purified water, stirred and fully dissolved to obtain a liquid B; and 3) the liquid B is added into the liquid A and stirred; the color change of the solution is observed, then the antifoaming agent and the osmotic agent are added, the pH value is detected and the liquid is canned, thus obtaining the finished product of the nano-silver wound-protection antiphlogistic liquid. The nano-silver wound-protection antiphlogistic liquid has the advantages of uniform dispersion, good stability, high total effective rate of treatment, low cost and simple technique; moreover, the nano-silver wound-protection antiphlogistic liquid is easy to form industrial production.
Description
Technical field
The present invention relates to a kind of mammal, for example the people is used for the antiinflammatory of surface wound, plays antibiotic, as to promote wound healing Wound-protection liquid, specifically is nano silver wound-protection anti-inflammation liquid;
The invention still further relates to a kind of preparation method of nano silver wound-protection anti-inflammation liquid.
Background technology
As everyone knows, silver has antibacterial effect: (1) he by with the pathogen cells metabolic enzyme in-sh is that sulfydryl combines, and makes enzyme deactivation, thereby killing microorganisms; (2) the Peptidoglycan reaction that exposes on he and the bacteria cell wall, blocking-up bacteria cell wall oxygen therapy activity causes pathogenic bacteria death; (3) he combines with the DNA of pathogen, forms cross-linkedly each other with the bonded silver of DNA base, has replaced the hydrogen bond between the adjacent nitrogen in fast cry of certain animals and the pyrimidine, causes the degeneration of DNA of bacteria structure, suppresses dna replication dna, makes the pathogenic bacteria inactivation.
Generally speaking, a kind of antibiotic roughly can kill several pathogenic bacterias, and silver can kill several one hundred kinds of antibacterials, and after antibacterial killed by silver, silver can dissociate out from the antibacterial that dies again, repeats killing bacteria.
By the high-tech nanotechnology, nanometer silver strengthens silver-colored bactericidal activity, compares with common silver, and the sterilizing ability of the silver under the nanometer state has produced qualitative leap, and only the nanometer silver with minute quantity can produce powerful bactericidal action.
Number of patent application is 200710019570.5, denomination of invention: Wound-protection liquid and preparation method thereof.Wound-protection liquid of a kind of surface wound external and preparation method thereof is disclosed.This Wound-protection liquid contains silver ion powder body, gelatin, binary acid, penetrating agent, tartaric acid.This invention mainly is that silver ion is fixed by gelatin and since in the solution silver be exist with ionic species meet anion such as chloride ion, bromide ion, iodide ion easily produces the silver compound precipitation, influences the stability of solution, affect the treatment.
Usually the preparation of nanometer silver is a silver ammino solution and contain aldehyde compound generation silver mirror reaction and generate silver and be distributed in the solution with dispersant, thereby produce nano-Ag particles, the kind of its required compound is many, as medical supplies, brings patient's uncertainty safe in utilization.And complex process will be regulated pH value, brings the instability of nanometer silver solution.
Summary of the invention
The object of the present invention is to provide and a kind ofly be uniformly dispersed, need not to regulate that pH value, good stability, penetration are strong, treatment body surface wound, burn and scald, nano silver wound-protection anti-inflammation liquid and preparation thereof that the gynecological inflammation total effective rate is high.Cost of the present invention is low, and preparation technology's method is simple, and sterilizing power is strong, and the cycle is short, forms suitability for industrialized production easily.
To achieve these goals, technical scheme of the present invention is:
A kind of nano silver wound-protection anti-inflammation liquid is characterized in that this wound-protection anti-inflammation liquid counts by weight percentage, and contains following composition:
AgNO
3: 0.06-0.12%; Hydroxyethyl-cellulose: 0.09-0.30%;
Penetrating agent: 0.10-0.40%; Defoamer: 1.0-4.0%;
Surplus is purified water.
Above-mentioned nano silver wound-protection anti-inflammation liquid, described hydroxyethyl-cellulose are pharmaceutical grade, are among the HEC10-1000 any; Described silver nitrate is an analytical pure; Described penetrating agent is the medicinal urea of test grade; Described defoamer is a dehydrated alcohol; Described purified water is deionized water or distilled water.
Above-mentioned deionized water is not chloride ion-containing, bromide ion, iodide ion especially.
The preparation method of above-mentioned nano silver wound-protection anti-inflammation liquid comprises the steps:
1). the percentage by weight of pressing the nano silver wound-protection anti-inflammation liquid ingredient calculates:
AgNO
3: 0.06-0.12%; Hydroxyethyl-cellulose: 0.09-0.30%
Penetrating agent; 0.10-0.40%; Defoamer: 1.0-4.0%;
Surplus is purified water, standby;
2). hydroxyethyl-cellulose added in the deionization purified water stirred 10-30 minute, be heated to 70-90 ℃ while stirring, obtain the hydroxyethyl-cellulose solution A, place stand-by;
3). with AgNO
3Join in the deionization purified water, stir thereafter, be stirred to it is fully dissolved, obtain silver nitrate solution B;
4). B liquid is joined in the A liquid, stirred the change color of observing solution while stirring 1-2 hour, when color by colourless be transformed into glassy yelloe after, stop to stir, be incubated 1 hour, thereafter water-bath is cooled to room temperature, continue then to stir 10-30 minute, add defoamer while stirring, then penetrating agent is added in chilled this solution, restir 5 minutes, the test pH value, fill obtains the finished product nano silver wound-protection anti-inflammation liquid.
Above-mentioned steps 2) to 4) in its mixing speed be 60r/min;
Above-mentioned steps 4) pH value of solution=6 described in.
The particle diameter of the nano-Ag particles of its nano silver wound-protection anti-inflammation liquid of glassy yelloe solution above-mentioned steps 4) is 10-30nm.
Above-mentioned steps 4) concentration of nanometer silver is 400-700ppm in its nano silver wound-protection anti-inflammation liquid of glassy yelloe solution described in.
Above-mentioned steps 4) defoamer described in is a dehydrated alcohol.
Above-mentioned steps 4) penetrating agent described in is a pharmaceutical grade carbamide.
Medicinal principle of the present invention:
One of medicinal principle of the present invention be him by with the pathogen cells metabolic enzyme in-sh is that sulfydryl combines, and makes enzyme deactivation, thereby killing microorganisms; Two are the Peptidoglycan reactions that expose on he and the bacteria cell wall, blocking-up bacteria cell wall oxygen therapy activity causes pathogenic bacteria death; Three he combine with the DNA of pathogen, form cross-linkedly each other with the bonded silver of DNA base, replaced the hydrogen bond between the adjacent nitrogen in fast cry of certain animals and the pyrimidine, cause the degeneration of DNA of bacteria structure, suppress dna replication dna, make the pathogenic bacteria inactivation.
The reason of the raw materials used composition of the present invention and effect:
1. water: deionization purified water, solvent;
2. hydroxyethyl-cellulose:
Hydroxyl is oxidized to aldehyde radical in Ag-containing solution, get silver particles with silver nitrate generation silver mirror reaction again, is again dispersant simultaneously, disperses silver particles, requires medical grade;
3. ethanol: defoamer, accurately use if any aeration fill and patient in the Wound-protection liquid, affect the treatment, dehydrated alcohol requires SILVER REAGENT;
4. carbamide: penetrating agent, title: urea, phosphoamide, carbonyl diamine, uueaphil, carbamide is the SILVER REAGENT medicinal urea, the accurate word H43020278 of medicine, quality standard meet state's pharmacopeia (2000 editions),
Carbamide solubilized keratin, the hydration of enhancing keratin protein strengthens the endermic penetrance of medicine, and has antipruritic, antibacterial action concurrently.
The preparation principle of nano silver wound-protection anti-inflammation liquid of the present invention:
The preparation of nanometer silver at present is that silver ammino solution generates silver particles with containing aldehyde compound generation silver mirror reaction, redispersion in solution, thereby make nano-Ag particles.And the present invention directly generates nano silver particles with hydroxy ethyl fiber cellulose solution generation silver mirror reaction with silver nitrate solution under the uniform temperature condition.Usually hydroxyethyl-cellulose is only done surfactant (dispersant) use.Among the present invention, utilize the C-OH base in the hydroxyethyl-cellulose silver mirror reaction takes place again to generate silver particles and be dispersed in again by each macromole of hydroxyethyl-cellulose changing into CHO under the effect of catalyst silver, make dispersant again and use.Because the hydroxyethyl-cellulose dispersion effect is good, nano silver particles is difficult for coalescent, so the present invention is uniformly dispersed, stability is better.
The present invention compared with prior art has following advantage:
1. directly hydroxy ethyl fiber cellulose solution and silver nitrate solution reaction are made nano silver particles in preparation method, method is simple especially.In prescription, add penetrating agent, defoamer again, make this wound-protection anti-inflammation liquid penetration stronger, wound surface deep layer pathogenic bacteria can be killed, treatment total effective rate height;
2. raw material variety is few, and cost is low; As medical products, increased the safety that the patient uses simultaneously.
This Wound-protection liquid nontoxic, have no side effect, environmental protection, long-time use do not develop immunity to drugs, this Wound-protection liquid is easy to use, conventional using method, no specific (special) requirements;
4. preparation method is simple, and processing step is few, and commercial production conditions is not high, easy realization of industrialization.
The specific embodiment
By non-restrictive example given below, further illustrate content of the present invention, understand the present invention.
Embodiment 1
The nanometer wound-protection anti-inflammation liquid mainly by:
AgNO
3: 0.06g; Hydroxyethyl-cellulose: 0.09g;
Carbamide: 0.10g ethanol: 1g
Deionization purified water: 98.75g
Above-mentioned nano silver wound-protection anti-inflammation liquid preparation comprise the steps:
A. the 0.09g hydroxyethyl-cellulose is joined in the 48.75g deionization purified water, stirred 15 minutes, be heated to 75 ℃ while stirring, obtain the hydroxyethyl-cellulose solution A, place stand-by with 60r/min speed;
B. with 0.06gAgNO
3Join in the 50g deionization purified water, be stirred to 60r/min speed it is fully dissolved, obtain silver nitrate solution B;
C. B liquid is joined in the A liquid, stirred 1-2 hour the change color of observing solution while stirring with 60r/min speed;
D. when color by colourless be transformed into glassy yelloe after, stop to stir, be incubated 1 hour, water-bath thereafter is cooled to room temperature, continues to stir 10 minutes with 60r/min speed then, add 1g ethanol while stirring, carbamide with 0.1g is added in chilled this solution then, with 60r/min speed restir 5 minutes, and test pH value=6, fill obtains the finished product nano silver wound-protection anti-inflammation liquid.
Embodiment 2
The nanometer wound-protection anti-inflammation liquid mainly by:
AgNO3:0.12g; Hydroxyethyl-cellulose: 0.3g;
Carbamide: 0.4g ethanol: 4g
Deionization purified water: 95.18g
Above-mentioned nano silver wound-protection anti-inflammation liquid preparation comprise the steps:
A. the 0.3g hydroxyethyl-cellulose is joined in the 45.18g deionization purified water, stirred 20 minutes, be heated to 80 ℃ while stirring, obtain the hydroxyethyl-cellulose solution A, place stand-by with 60r/min speed;
B. with 0.12g AgNO
3Join in the 50g deionization purified water, be stirred to 60r/min speed it is fully dissolved, obtain silver nitrate solution B;
C. B liquid is joined in the A liquid, stirred 1-2 hour the change color of observing solution while stirring with 60r/min speed;
D. when color by colourless be transformed into glassy yelloe after, stop to stir, be incubated 1 hour, water-bath thereafter is cooled to room temperature, continues 15 minutes with 60r/min speed then, add 4g ethanol while stirring, then 0.4g carbamide is added in chilled this solution, with 60r/min speed restir 5 minutes, test pH value=6, fill obtains the finished product nano silver wound-protection anti-inflammation liquid.
Embodiment 3
The nanometer wound-protection anti-inflammation liquid mainly by:
AgNO3:0.10g; Hydroxyethyl-cellulose: 0.18g;
Carbamide: 0.30g ethanol: 2.50g
Deionization purified water: 96.92g
Above-mentioned nano silver wound-protection anti-inflammation liquid preparation comprise the steps:
A. the 0.18g hydroxyethyl-cellulose is added in the arrival 46.92g deionization purified water, stirred 25 minutes, be heated to 85 ℃ while stirring, obtain the hydroxyethyl-cellulose solution A, place stand-by with 60r/min speed;
B. with 0.10g AgNO
3Join in the 50g deionization purified water, be stirred to 60r/min speed it is fully dissolved, obtain silver nitrate solution B;
C. B liquid is joined in the A liquid, stirred 1-2 hour the change color of observing solution while stirring with 60r/min speed;
D. when color by colourless be transformed into glassy yelloe after, stop to stir, be incubated 1 hour, water-bath thereafter is cooled to room temperature, continues to stir 30 minutes with 60r/min speed then, add 2.50g ethanol while stirring, then 0.30g carbamide is added in chilled this solution, with 60r/min speed restir 5 minutes, test pH value=6, fill obtains the finished product nano silver wound-protection anti-inflammation liquid.
Embodiment 4
The nanometer wound-protection anti-inflammation liquid mainly by:
AgNO
3: 0.08g; Hydroxyethyl-cellulose: 0.15g;
Carbamide: 0.2g ethanol: 2.0g
Deionization purified water: 97.57g
Above-mentioned nano silver wound-protection anti-inflammation liquid preparation comprise the steps:
A. the 0.15g hydroxyethyl-cellulose is added in the arrival 47.57g deionization purified water, stirred 28 minutes, be heated to 90 ℃ while stirring, obtain the hydroxyethyl-cellulose solution A, place stand-by with 60r/min speed;
B. with 0.08gAgNO
3Join in the 50g deionization purified water, be stirred to 60r/min speed it is fully dissolved, obtain silver nitrate solution B;
C. B liquid is joined in the A liquid, stirred 1-2 hour the change color of observing solution while stirring with 60r/min speed;
D. when color by colourless when being transformed into glassy yelloe, stop to stir, be incubated 1 hour, thereafter water-bath is cooled to room temperature, continues to stir 20 minutes with 60r/min speed then, adds 2.0g ethanol while stirring, 0.2g carbamide is added in chilled this solution then, with 60r/min speed restir 5 minutes, test pH value=6 fills obtained the finished product nano silver wound-protection anti-inflammation liquid.
By the preparation-obtained nano silver wound-protection anti-inflammation liquid of the foregoing description 1-4 respectively through Southeast China University's toxicology test and Jiangsu Province's Taizhou City Disease Control and Prevention Center antibacterial tests..
One. Taizhou City Disease Control and Prevention Center examining report:
Sample character: liquid; Sample size: 100mL/ bottle X10 bottle;
Detect foundation: " disinfection technology standard " 2002 editions;
Detect equipment:
1. test strain: staphylococcus aureus (ATCC6538) third generation Jiangsu Province microorganism reagent factory of Disease Control and Prevention Center
Escherichia coli (8099) third generation Jiangsu Province microorganism reagent factory of Disease Control and Prevention Center
Candida albicans (ATCC10231) third generation Jiangsu Province microorganism reagent factory of Disease Control and Prevention Center
2. test specimen: nano silver wound-protection anti-inflammation liquid
Phosphate buffer (PBS0.03moL/L, PH7.2)
4. culture medium: ordinary nutrient agar culture medium
Husky fort agar culture medium
Sense environmental conditions: temperature (0C): 25 humidity (%RH): 34
Main detecting instrument: GNP-9270 water isolation type constant incubator
Testing result:
Annotate: staphylococcus aureus (ATCC6538) bacterium liquid bacteria containing amount: 8.0 X 10
6CFU/ML
Escherichia coli (8099) bacterium liquid bacteria containing amount: 8.2 X 10
5CFU/ML
Candida albicans (ATCC10231) bacterium liquid bacteria containing amount: 8.8 X 10
6CFU/ML
Detect conclusion: institute's inspection project all meets the method and the standard of GB15981-1995 sterilization and sterilization effect " requirement.
Two. Southeast China University's Hygiene Toxicology survey report
Sample title: nano silver wound-protection anti-inflammation liquid sample size: 10 bottles
Sample character: yellow transparent liquid
Test basis: " disinfection technology standard 2002 editions
Check conclusion: nano silver wound-protection anti-inflammation liquid toxicology testing result is as follows:
1. skin irritation test: the rabbit skin irritation index is 0, and according to the irritant reaction strength grading, nano silver wound-protection anti-inflammation liquid belongs to nonirritant.
2. vaginal mucomembranous irritant test: rabbit vagina mucous membrane irritation index is 1.00, and according to the classification of vaginal mucosa irritation response strength, nano silver wound-protection anti-inflammation liquid belongs to utmost point subexcite.
Learn that from Southeast China University's toxicology test and the report of Jiangsu Province's Taizhou City Disease Control and Prevention Center antibacterial tests nano silver wound-protection anti-inflammation liquid of the present invention is non-stimulated to skin, mucosa, to the killing rate of staphylococcus aureus, escherichia coli, Candida albicans greater than 99.9%.
Claims (9)
1. nano silver wound-protection anti-inflammation liquid is characterized in that this wound-protection anti-inflammation liquid counts by weight percentage, and contains following composition:
AgNO
3: 0.06-0.12%; Hydroxyethyl-cellulose: 0.09-0.30%;
Penetrating agent: 0.10-0.40%; Defoamer: 1.0-4.0%;
Surplus is purified water.
2. nano silver wound-protection anti-inflammation liquid according to claim 1, it is characterized in that described hydroxyethyl-cellulose is a pharmaceutical grade, model is any among HEC10, HE20, HE50, HEC100, HEC200, HEC300, HEC500, the HEC1000, and viscosity is 8-1200 (mPa.s); Described silver nitrate is the analytical pure silver nitrate; Described penetrating agent is the medicinal urea of SILVER REAGENT; Described defoamer is the analytical pure dehydrated alcohol; Described purified water is deionized water or distilled water.
3. nano silver wound-protection anti-inflammation liquid according to claim 2 is characterized in that described deionized water special requirement do not contain anion, as chloride ion, bromide ion, iodide ion.
4. the preparation method of a nano silver wound-protection anti-inflammation liquid as claimed in claim 1 is characterized in that comprising the steps:
1). the percentage by weight of pressing the nano silver wound-protection anti-inflammation liquid ingredient calculates:
AgNO
3: 0.06-0.12%; Hydroxyethyl-cellulose: 0.09-0.30%;
Penetrating agent: 0.10-0.40%; Defoamer: 1.0-4.0%;
Surplus is purified water, standby;
2). hydroxyethyl-cellulose was added deionized water for stirring 10-30 minute, be heated to 70-90 while stirring
0C obtains the hydroxyethyl-cellulose solution A, places stand-by;
3). with AgNO
3Join in the deionized water, stir thereafter, be stirred to it is fully dissolved, obtain silver nitrate solution B;
4). B liquid is joined in the A liquid, stirred the change color of observing solution while stirring 1-2 hour, when color by colourless be transformed into glassy yelloe after, stop to stir, be incubated 1 hour, thereafter water-bath is cooled to room temperature, continue then to stir 10-30 minute, add defoamer while stirring, then penetrating agent is added in chilled this solution, restir 5 minutes, the test pH value, fill obtains the finished product nano silver wound-protection anti-inflammation liquid.
5. as the preparation method of a kind of nano silver wound-protection anti-inflammation liquid according to claim 4, it is characterized in that testing described in the step 4) pH value, pH value=6.
6. as the preparation method of a kind of nano silver wound-protection anti-inflammation liquid according to claim 4, it is characterized in that the particle diameter of the nano-Ag particles of its nano silver wound-protection anti-inflammation liquid of the solution of glassy yelloe described in the step 4) is 10-30nm; The concentration of nanometer silver is 400-700ppm in described its nano silver wound-protection anti-inflammation liquid of glassy yelloe solution.
7. as the preparation method of a kind of nano silver wound-protection anti-inflammation liquid according to claim 4, its feature is in described step 2) to 4) in its mixing speed be 60r/min.
8. as the preparation method of a kind of nano silver wound-protection anti-inflammation liquid according to claim 4, it is characterized in that the defoamer described in the step 4) is the analytical pure dehydrated alcohol.
9. as the preparation method of a kind of nano silver wound-protection anti-inflammation liquid according to claim 4, it is characterized in that the penetrating agent described in the step 4) is the medicinal urea of SILVER REAGENT.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106691924A (en) * | 2016-12-12 | 2017-05-24 | 佛山市金纳新材料科技有限公司 | Nano silver composite antibacterial liquid soap and preparation method thereof |
| CN107468639A (en) * | 2017-08-29 | 2017-12-15 | 厦门康心元聚生物科技有限公司 | A kind of gynaecologic antibiotic gel and preparation method thereof |
-
2008
- 2008-12-05 CN CN2008102357573A patent/CN101422484B/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106691924A (en) * | 2016-12-12 | 2017-05-24 | 佛山市金纳新材料科技有限公司 | Nano silver composite antibacterial liquid soap and preparation method thereof |
| CN107468639A (en) * | 2017-08-29 | 2017-12-15 | 厦门康心元聚生物科技有限公司 | A kind of gynaecologic antibiotic gel and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101422484B (en) | 2010-08-04 |
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