CN104887704A - Nanometer silver disinfection liquid and preparation method thereof - Google Patents
Nanometer silver disinfection liquid and preparation method thereof Download PDFInfo
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- CN104887704A CN104887704A CN201410077296.7A CN201410077296A CN104887704A CN 104887704 A CN104887704 A CN 104887704A CN 201410077296 A CN201410077296 A CN 201410077296A CN 104887704 A CN104887704 A CN 104887704A
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Abstract
The invention relates to a nanometer silver disinfection liquid, which contains a nanometer silver colloid, dehydrated alcohol and a synergist, wherein silver nitrate and a reducing agent vitamin C are subjected to an oxidation-reduction reaction under the effect of a stabilizer polyvinyl pyrrolidone to prepare the nanometer silver colloid, and the synergist is chlorhexidine acetate. The preparation method comprises: uniformly mixing 0.005-0.1 M of the prepared vitamin C solution, 0.005-0.3 M of the prepared polyvinyl pyrrolidone solution, 0.001-0.01 M of the prepared chlorhexidine acetate solution and dehydrated alcohol according to equal volume ratio; heating to a temperature of 45-55 DEG C; adding 0.001-0.5 M of a silver nitrate having the same volume as the synergist to the mixed solution in a dropwise manner at a speed of 3-5 ml/min, wherein the speed is controlled so as to prevent the precipitation generation; and after completing the adding, stirring for 3-5 h under a condition of 1000-5000 RPM so as to obtain the desired product.
Description
Technical field
The invention belongs to disinfecting field, be specifically related to a kind of nano-silver antiseptic solution and preparation method thereof.
Background technology
Nanometer silver (Nano Silver) is exactly particle diameter is accomplished nano level argent simple substance.Nanometer silver particle diameter is mostly at 25 ran, strong suppression and killing action is had to tens of kinds of pathogenic microorganism such as escherichia coli, gonococcus, chlamydia trachomatiss, drug resistance can not be produced, and the reparation of the healing of wound, the growth of cell and damaged cell can be promoted, without any toxic reaction, also do not find any irritant reaction to skin, this opens wide prospect to extensive use nanometer silver antimicrobial, is the natural disinfectant agent of latest generation.
But current existing nano-silver antiseptic solution cost is high, complicated process of preparation:
1, directly prepare nano-silver antiseptic solution by nanometer silver powder, cost is high, as patent CN200810030220 " a kind of nano-silver antiseptic solution ".
2, the additive in disinfectant is expensive, nano silver disinfectant preparation technology equipment requirements is high, can not extensive use: as patent CN200510066437.6 " propolis and silver ion composite nanometer disinfectant and preparation method thereof " proposes propolis and silver ion composite nanometer disinfectant, propolis is expensive, and needs magnetic agitation etc.
3, the additive in disinfectant mostly is volatile oil component, active component is Chinese medicine extract, extract difficulty, patent working method is loaded down with trivial details: add as proposed in Chinese patent CN200910105563 " a kind of nano silver disinfectant " the quick sterilization effect that active component improves nanometer silver.
Summary of the invention
The object of this invention is to provide cost low, can a kind of nano-silver antiseptic solution of effective killing pathogenic bacteria fast.
Another object of the present invention is to provide a kind of preparation method of above-mentioned nano-silver antiseptic solution.
The embodiment of the present invention is achieved in that
A kind of nano-silver antiseptic solution contains nano silver colloid, dehydrated alcohol and synergist.Wherein nano silver colloid is by silver nitrate and reducing agent vitamin C, under the effect of stabilizing agent polyvinylpyrrolidone, is obtained by redox reaction.N and Ag in stabilizing agent polyvinylpyrrolidone forms complex bonds, and superpolymer polyethylene ketopyrrolidine is fixed on nanometer silver surface, is wrapped up by nanometer silver, provides effectively sterically hindered, silver particles is not reunited, thus forms nano silver colloid; Synergist is chlorhexidine acetate; Dehydrated alcohol, suppresses the oxidation of disinfectant solution.
The preparation method of a kind of upper nano-silver antiseptic solution provided by the invention, comprises following operation:
(1) with deionization water as solvent, the silver nitrate solution of the vitamin c solution of the 0.005-0.1M of same volume, the polyvinylpyrrolidonesolution solution of 0.005-0.3M, the chlorhexidine acetate solution of 0.001-0.01M and 0.0001-0.1M is prepared respectively.
(2) use normal agitation machine under 1000RPM ~ 5000RPM stirring condition, by vitamin c solution, polyvinylpyrrolidonesolution solution, chlorhexidine acetate solution and dehydrated alcohol mix homogeneously, be heated to 45 DEG C-55 DEG C.
(3) in above-mentioned mixed solution, dropwise add 0.001-0.5M silver nitrate solution, speed is 3 ~ 5ml/min, and control rate prevents precipitation, stirs 3-5h, obtain required product after adding under 1000RPM ~ 5000RPM condition.
Owing to carrying out technique scheme, the present invention configures raw material and is easy to get, compound method is simple, nano-Ag particles directly enters thalline and oxygen metabolism enzyme (-SH) combines, make the unique mechanism of action that thalline is choked to death, the most of antibacterials be in contact with it can be killed, fungus, mycete, the microorganisms such as spore, and chlorhexidine acetate belongs to biguanides disinfectant, and it is cationic surfactant, the film that the water-soluble anion side of cation side group can embed lipid like membrane structure breaks tearing of it, bactericidal action is played by the membrane structure of destroy microorganisms, synergism is had with nanometer silver, reduce sterilizing time, strengthen bactericidal action, various antibacterial can be killed fast.
Detailed description of the invention:
A kind of preparation method of nano-silver antiseptic solution:
Embodiment 1
1, with deionization water as solvent, the silver nitrate solution 1000ml of the polyvinylpyrrolidonesolution solution 1000ml of vitamin c solution 1000ml, 0.2mol/L of 0.1mol/L, chlorhexidine acetate solution 1000ml and 0.02mol/L of 0.005mol/L is prepared respectively.
2, under 1000RPM stirring condition, by VC solution, PVP solution, chlorhexidine acetate solution and 1000ml dehydrated alcohol mix homogeneously, 45 DEG C are heated to.
3, in mixed solution, dropwise add silver nitrate solution, speed is 3ml/min, and control rate prevents precipitation, stirs 3h, obtain light brown gel liquid 5000ml after adding under 5000RPM condition.
Embodiment 2
1, with deionization water as solvent, the silver nitrate solution 1000ml of the polyvinylpyrrolidonesolution solution 1000ml of vitamin c solution 1000ml, 0.1mol/L of 0.05mol/L, chlorhexidine acetate solution 1000ml and 0.01mol/L of 0.005mol/L is prepared respectively.
2, under 1000RPM stirring condition, by VC solution, PVP solution, chlorhexidine acetate solution and 1000ml dehydrated alcohol mix homogeneously, 45 DEG C are heated to.
3, in mixed solution, dropwise add silver nitrate solution, speed is 3ml/min, and control rate prevents precipitation, stirs 3h, obtain light brown gel liquid 5000ml after adding under 5000RPM condition.
Embodiment 3
1, with deionization water as solvent, the silver nitrate solution 1000ml of the polyvinylpyrrolidonesolution solution 1000ml of vitamin c solution 1000ml, 0.2mol/L of 0.1mol/L, chlorhexidine acetate solution 1000ml and 0.01mol/L of 0.005mol/L is prepared respectively.
2, under 1000RPM stirring condition, by VC solution, PVP solution, chlorhexidine acetate solution and 1000ml dehydrated alcohol mix homogeneously, 45 DEG C are heated to.
3, in mixed solution, dropwise add silver nitrate solution, speed is 3ml/min, and control rate prevents precipitation, stirs 3h, obtain light brown gel liquid 5000ml after adding under 5000RPM condition.
1 year can be preserved under this product lucifuge, room temperature, this product directly can be spread upon on hands, skin and be applicable to general surface disinfection.
The present invention is through Xinjiang Uygur Autonomous Region Disease Control & Prevention Center according to " disinfection technology standard " Ministry of Public Health version in 2002, and carry out Guantitative bactericidal test, result illustrates that this product can kill staphylococcus aureus, escherichia coli, Candida albicans effectively; Field trial, result illustrates that this product reaches sterilization requirement.
Concrete test data see table 1 to table 2:
Table 1 disinfectant solution bactericidal property examining report
Detect foundation: " disinfection technology standard " Ministry of Public Health version in 2002, sterile products inspection technology specification 2.1.1.7 Guantitative bactericidal test, the quantitative sterilize experiment of 2.1.1.9 fungus.Testing time: 5 minutes.
Detect unit: Xinjiang Uygur Autonomous Region Disease Control & Prevention Center.
Table 2 hands on-site disinfection test is reported
Note: the negative control group of the set culture medium of each test, sample solution, cotton swab, equal asepsis growth.
Detect foundation: " disinfection technology standard " Ministry of Public Health version in 2002, sterile products inspection technology specification 2.1.2.6 disinfectant is to this product field trial.
Testing time: 1 minute.
Detect unit: Xinjiang Uygur Autonomous Region Disease Control & Prevention Center.
Result of the test: this disinfectant solution is applied in 30 experimenter's right hands and bends face, action time is 1 minute, is all greater than 1.00, reaches sterilization requirement to the kill oncomelania of experimenter's watch face natural bacteria.
Above technical characteristic constitutes most preferred embodiment of the present invention, and it has stronger adaptability and best implementation result, can increase and decrease inessential technical characteristic according to actual needs, meet the needs of different situations.
Claims (4)
1. a nano-silver antiseptic solution, containing silver nitrate solution, reducing agent, stabilizing agent, dehydrated alcohol and synergist, it is characterized in that reducing agent is vitamin c solution, stabilizing agent is polyvinylpyrrolidonesolution solution, stabilizing agent is polyvinylpyrrolidonesolution solution, synergist is chlorhexidine acetate solution.
2. a kind of nano-silver antiseptic solution according to claim 1, it is characterized in that it contains the following every solution in parts by volume: 0.001-0.5M silver nitrate solution 1 part, 0.005-0.1M vitamin c solution 1 part, 0.005-0.3M polyvinylpyrrolidonesolution solution 1 part, the chlorhexidine acetate solution of 0.001-0.01M 1 part, dehydrated alcohol 1 part.
3. the preparation method of a kind of nano-silver antiseptic solution according to claim 2, comprise following operation: under room temperature, by reducing agent, stabilizing agent, dehydrated alcohol and synergist mix homogeneously, be heated to 45 DEG C-55 DEG C, dropwise silver nitrate solution is added again in above-mentioned mixed solution, under 1000RPM-5000RPM condition, stir 3-5h after adding, obtain required product.
4. the preparation method of a kind of nano-silver antiseptic solution according to claim 3, is characterized in that: the speed dripping silver nitrate solution is 3 ~ 5ml/min.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105664168A (en) * | 2016-03-02 | 2016-06-15 | 中国科学院武汉植物园 | Preparation method and application of drug-loading nano silver particles |
| CN106973796A (en) * | 2017-06-01 | 2017-07-25 | 广东鼎峰生态农业开发有限公司 | A kind of tissue cultivating and seedling method of Idesia polycarpa |
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| US20020136780A1 (en) * | 2001-01-22 | 2002-09-26 | Batarseh Kareem I. | Microbicidal composition containing potassium sodium tartrate |
| CN1876293A (en) * | 2006-04-03 | 2006-12-13 | 庄平 | Nano-class silver colloidal solution and preparation method thereof |
| CN101716186A (en) * | 2010-01-20 | 2010-06-02 | 华南理工大学 | Wound antibiotic flushing fluid and preparation method thereof |
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2014
- 2014-03-04 CN CN201410077296.7A patent/CN104887704A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020136780A1 (en) * | 2001-01-22 | 2002-09-26 | Batarseh Kareem I. | Microbicidal composition containing potassium sodium tartrate |
| CN1876293A (en) * | 2006-04-03 | 2006-12-13 | 庄平 | Nano-class silver colloidal solution and preparation method thereof |
| CN101716186A (en) * | 2010-01-20 | 2010-06-02 | 华南理工大学 | Wound antibiotic flushing fluid and preparation method thereof |
Non-Patent Citations (2)
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| 张紫虹 等: "纳米银复合醋酸氯己定消毒凝胶杀菌效果及毒性研究", 《中国卫生检验杂志》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105664168A (en) * | 2016-03-02 | 2016-06-15 | 中国科学院武汉植物园 | Preparation method and application of drug-loading nano silver particles |
| CN106973796A (en) * | 2017-06-01 | 2017-07-25 | 广东鼎峰生态农业开发有限公司 | A kind of tissue cultivating and seedling method of Idesia polycarpa |
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Application publication date: 20150909 |