CN113491709A - Multifunctional efficient compound disinfectant and preparation method thereof - Google Patents
Multifunctional efficient compound disinfectant and preparation method thereof Download PDFInfo
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- CN113491709A CN113491709A CN202010256495.XA CN202010256495A CN113491709A CN 113491709 A CN113491709 A CN 113491709A CN 202010256495 A CN202010256495 A CN 202010256495A CN 113491709 A CN113491709 A CN 113491709A
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- disinfectant
- compound disinfectant
- water
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- multifunctional
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 67
- 150000001875 compounds Chemical class 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 229920002413 Polyhexanide Polymers 0.000 claims abstract description 32
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000004094 surface-active agent Substances 0.000 claims abstract description 15
- 239000003906 humectant Substances 0.000 claims abstract description 13
- 239000002562 thickening agent Substances 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims description 9
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 claims description 9
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 7
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 7
- 239000000686 essence Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 claims description 7
- 238000010907 mechanical stirring Methods 0.000 claims description 7
- 239000011259 mixed solution Substances 0.000 claims description 7
- 229940126589 solid medicine Drugs 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 7
- 239000013589 supplement Substances 0.000 claims description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- 241000220317 Rosa Species 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 4
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 4
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 2
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 241000196324 Embryophyta Species 0.000 claims description 2
- 235000016623 Fragaria vesca Nutrition 0.000 claims description 2
- 240000009088 Fragaria x ananassa Species 0.000 claims description 2
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 235000010254 Jasminum officinale Nutrition 0.000 claims description 2
- 240000005385 Jasminum sambac Species 0.000 claims description 2
- 244000178870 Lavandula angustifolia Species 0.000 claims description 2
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 2
- 240000000513 Santalum album Species 0.000 claims description 2
- 235000008632 Santalum album Nutrition 0.000 claims description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 235000011399 aloe vera Nutrition 0.000 claims description 2
- 229960003872 benzethonium Drugs 0.000 claims description 2
- FNXLCIKXHOPCKH-UHFFFAOYSA-N bromamine Chemical compound BrN FNXLCIKXHOPCKH-UHFFFAOYSA-N 0.000 claims description 2
- 235000013877 carbamide Nutrition 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 2
- SIYLLGKDQZGJHK-UHFFFAOYSA-N dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium Chemical compound C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 SIYLLGKDQZGJHK-UHFFFAOYSA-N 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 229940014259 gelatin Drugs 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 235000012907 honey Nutrition 0.000 claims description 2
- 239000001102 lavandula vera Substances 0.000 claims description 2
- 235000018219 lavender Nutrition 0.000 claims description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 claims description 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 2
- 239000001540 sodium lactate Substances 0.000 claims description 2
- 229940005581 sodium lactate Drugs 0.000 claims description 2
- 235000011088 sodium lactate Nutrition 0.000 claims description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 229960002920 sorbitol Drugs 0.000 claims description 2
- 235000010356 sorbitol Nutrition 0.000 claims description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 2
- 244000144927 Aloe barbadensis Species 0.000 claims 1
- 235000002961 Aloe barbadensis Nutrition 0.000 claims 1
- 235000019270 ammonium chloride Nutrition 0.000 claims 1
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 23
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 13
- 241000222122 Candida albicans Species 0.000 abstract description 10
- 229940095731 candida albicans Drugs 0.000 abstract description 10
- 230000008901 benefit Effects 0.000 abstract description 6
- 230000007613 environmental effect Effects 0.000 abstract description 5
- 244000005700 microbiome Species 0.000 abstract description 4
- 238000001228 spectrum Methods 0.000 abstract description 4
- 241000588724 Escherichia coli Species 0.000 abstract description 3
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 244000052616 bacterial pathogen Species 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract description 2
- 231100000956 nontoxicity Toxicity 0.000 abstract description 2
- 241000712461 unidentified influenza virus Species 0.000 abstract description 2
- 238000005406 washing Methods 0.000 abstract description 2
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000002791 soaking Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 20
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 14
- 239000003899 bactericide agent Substances 0.000 description 10
- 230000001954 sterilising effect Effects 0.000 description 10
- 241000894006 Bacteria Species 0.000 description 9
- 238000001514 detection method Methods 0.000 description 9
- 230000002147 killing effect Effects 0.000 description 8
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 7
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 7
- 229960004198 guanidine Drugs 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000013095 identification testing Methods 0.000 description 5
- -1 polyhexamethylene monoguanidine Chemical class 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 230000003472 neutralizing effect Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 229960002152 chlorhexidine acetate Drugs 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical compound Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 description 3
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical class CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 241000700605 Viruses Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229960002233 benzalkonium bromide Drugs 0.000 description 2
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 2
- WLCFKPHMRNPAFZ-UHFFFAOYSA-M didodecyl(dimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCC WLCFKPHMRNPAFZ-UHFFFAOYSA-M 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000008233 hard water Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Chemical class CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
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- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 1
- 108010013639 Peptidoglycan Proteins 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229940082484 carbomer-934 Drugs 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 210000002390 cell membrane structure Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
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- 239000002158 endotoxin Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to a multifunctional high-efficiency compound disinfectant and a preparation method thereof, wherein the disinfectant comprises the following main components: 0.01-2.0% of polyhexamethylene biguanide hydrochloride (PHMB), 0.05-0.2% of water-soluble quaternary ammonium salt, 0.1-2.0% of surfactant, 0.05-1.5% of thickening agent, 0.05-2.0% of humectant, 0.001-0.1% of essence, 0-40.0% of medical ethanol and the balance of pure water. The efficient multifunctional compound disinfectant has the characteristics of wide bactericidal spectrum (remarkable disinfection effect on staphylococcus aureus, escherichia coli, candida albicans, influenza virus and other germs), wide application range, wide application method (disinfection by wiping, soaking and washing), no toxicity, environmental protection, long acting and the like; the compound component has the advantages of low dosage and high activity, and the preparation cost is relatively low; the polyhexamethylene biguanide hydrochloride is a main active ingredient, is not absorbed and remained by skin, does not generate drug resistance to various microorganisms, has no toxic or side effect, and can meet the requirement of people on safe disinfectants.
Description
Technical Field
The invention relates to the technical field of disinfectant, in particular to a multifunctional efficient compound disinfectant and a preparation method thereof.
Background
The existence of microorganisms such as viruses, bacteria, fungi and the like directly threatens the health of human beings and the development of society, so that the development of the disinfectant which has the advantages of broad spectrum, high efficiency, rapidness, low toxicity, convenient carrying, convenient use and wide use range becomes a current research hotspot. Currently, there are two problems with disinfectant research: firstly, the development cost of the ideal disinfectant with safety, high efficiency, environmental protection and broad spectrum is high and the difficulty is large; second, long-term use of a single chemically-synthesized disinfectant is likely to cause microbial resistance. With the continuous progress of society, the living standard of people is continuously improved, and the sanitary civilization consciousness is also continuously strengthened. Therefore, people pay more attention to sanitation and safety in various public places. The types of the bactericides are various, and the bactericidal effect of the bactericides is influenced by the bactericidal components and the dosage. Bacterial, fungal, viral and the like resistance can also affect the bactericidal effect. In the new century, green chemistry has received attention of broad scholars and becomes one of the international scientific research fronts. Therefore, at home and abroad bactericide researchers are focusing on the research and development of ideal bactericides with safety, high efficiency, environmental protection and broad spectrum. Because the ideal bactericide has high research and development cost and great difficulty, researchers mainly research the compounding, synergistic effect, action mechanism and the like of the bactericide at present.
The guanidine and quaternary ammonium salt disinfectant is a novel environment-friendly disinfectant, has extremely strong sterilization and bacteriostasis performance, broad spectrum and high efficiency, long validity period, no toxic or side effect, no corrosiveness and irritation, safe use, degradability in natural environment, environmental friendliness and no pollution, and is a main component for developing novel disinfectants in recent years.
The quaternary ammonium salt bactericide comprises two types of single-chain (such as benzalkonium chloride and benzalkonium bromide) and double-chain quaternary ammonium salt (such as didecyl dimethyl ammonium chloride and DDAC), one end of the quaternary ammonium salt bactericide is positively charged, and the other end of the quaternary ammonium salt bactericide is a cationic surface active disinfectant, wherein the sterilization mechanism is that the positively charged quaternary ammonium salt unit is adsorbed on the surface of a negatively charged bacterium, and the long-chain alkyl/aryl unit is combined with substances on a cell lipid layer as a lipophilic group to damage the cell wall and cell membrane structure of the bacterium, so that the cell permeability is changed, the substances in the cell are leaked out, the activity of related enzymes is inhibited, and proteins are denatured, so that the bacterium is killed.
Guanidine bactericide includes chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene monoguanidine, polyhexamethylene biguanide salt derivative, etc., for example, chlorhexidine acetate and chlorhexidine gluconate compound preparation is sold in market. Guanidine sterilization mechanism is similar to that of quaternary ammonium salt, guanidine with a large number of positive charges can be quickly adsorbed to the surface of bacteria to replace Mg2+ and Ca2+ stably existing on the surface of the bacteria, and the guanidine mainly interacts with lipopolysaccharide, peptidoglycan components and cytoplasmic membranes on cell walls to change the phospholipid environment of the cell membranes, so that biological dysfunction of the cell membranes is caused, the structure of the cytoplasmic membranes is damaged, and microorganism death is caused. In addition, polyhexamethylene mono/biguanide (PHMG/PHMB) as a polymer can form a membrane on the surface of the microorganism to close its respiratory tract, thus asphyxiating the bacteria. It is known that the single component bactericidal spectrum is narrow, for example, the dosage of 100% of polyhexamethylene guanidine hydrochloride for the sterilization rate of escherichia coli, staphylococcus aureus and candida albicans is only 200ppm, but the single component bactericidal spectrum is not suitable for killing cellular spores. For example, the quaternary ammonium salt has the same bactericidal capacity on the common pseudomonas aeruginosa in a hospital surgical operating room, besides the bactericidal capacity of the quaternary ammonium salt on the polyhexamethylene guanidine hydrochloride, wherein the bactericidal rate is 99.999 percent, the dosage is only 39ppm, and the bactericidal effect on virus inactivation is weaker. Research shows that the active components have synergistic effect after being compounded in a certain proportion, and the compounded disinfectant can broaden the bactericidal flora and enhance the bactericidal capacity, for example, the disinfectant prepared by respectively compounding guanidine with ethanol, didodecyl dimethyl ammonium chloride, benzalkonium bromide and chlorhexidine acetate has better effect in literature reports, wherein the disinfectant prepared by compounding with didodecyl dimethyl ammonium chloride has the best disinfection effect. In addition: the compounded disinfectant can effectively reduce the dosage of the disinfectant under the condition of ensuring the sterilization standard, and the purposes of high efficiency, low toxicity, economy and practicability are realized.
Disclosure of Invention
The invention aims at solving some problems of the existing disinfectant, develops a high-efficiency compound disinfectant in a targeted manner, and aims to provide a multifunctional high-efficiency compound disinfectant with good disinfection effect, no toxicity, environmental protection and low cost.
The technical scheme for realizing the invention is as follows: the multifunctional efficient compound disinfectant is characterized by being prepared from the following components in percentage by weight:
| polyhexamethylene biguanide hydrochloride (PHMB) | 0.01～2.0％ |
| Water soluble quaternary ammonium salts | 0.05～0.2％ |
| Surface active agent | 0.1～2.0％ |
| Thickening agent | 0～1.5％ |
| Moisture-retaining agent | 0～2.0％ |
| Essence | 0.001～0.1％ |
| Medical ethanol | 0～40.0％ |
| Pure water | Balance of |
The multifunctional high-efficiency compound disinfectant is characterized in that: the dosage of the polyhexamethylene biguanide hydrochloride (PHMB) is 0.01-2.0%; the water-soluble quaternary ammonium salt is one of benzalkonium chloride/bromamine, Didecyl Dimethyl Ammonium Chloride (DDAC) and benzethonium bromide, and the dosage of the water-soluble quaternary ammonium salt is 0.05-0.2%.
The multifunctional high-efficiency compound disinfectant is characterized in that: the surfactant is one or more of polyoxyethylene ether (AEO/JFC/NP/OP/TX), Glyceryl Monostearate (GM), cocamidopropyl betaine 8(CAB) and Alkyl Polyglycoside (APG), and the dosage of the surfactant is 0.1-2.0%.
The hand-washing-free efficient compound disinfectant is characterized in that: the thickening agent is one or more of polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyvinylpyrrolidone or carbomer, and the dosage of the thickening agent is 0.05-1.5%.
The multifunctional high-efficiency compound disinfectant is characterized in that: the humectant is one or more of glycerin, propylene glycol, aloe gel, sodium hyaluronate, carbamide, honey, sodium lactate, sorbitol, pyrrolidone carboxylic acid and gelatin, and the dosage of the humectant is 0.05-2.0%.
The multifunctional high-efficiency compound disinfectant is characterized in that: the essence is one of rose, jasmine, lavender, sandalwood, mint, strawberry and the like in plant essence, and the dosage of the essence is 0.001-0.1%.
The multifunctional high-efficiency compound disinfectant is characterized in that: the preparation method comprises the following steps:
(1) dissolving the solid medicines in the ingredient table in water in advance to prepare aqueous solution with corresponding concentration for later use;
(2) respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, surfactant, thickener, humectant, essence and medical ethanol into a reaction kettle with mechanical stirring, and adding pure water to supplement to a certain volume;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) and filtering and subpackaging the uniformly stirred solution to obtain the high-efficiency compound multifunctional disinfectant.
The invention has the following advantages:
1. the main effective sterilization components of the multifunctional high-efficiency compound disinfectant provided by the invention are nontoxic and environment-friendly macromolecular guanidine and double-chain quaternary ammonium salt, an effective protective film can be formed on the surface of skin, and the multifunctional high-efficiency compound disinfectant has the effects of high-efficiency sterilization and long-acting bacteriostasis.
2. The multifunctional efficient compound disinfectant provided by the invention adopts a compound formula, makes full use of the synergistic effect of the components, and has the advantages of small dosage, good sterilization effect, wide sterilization spectrum and the like.
3. The multifunctional efficient compound disinfectant provided by the invention contains the surfactant, can effectively enhance the sterilization effect of the main component, reduces the irritation, and has the advantages of no skin chapping and no skin peeling after use.
4. The multifunctional efficient compound disinfectant provided by the invention contains components for moistening skin and moisture, and has the characteristics of good moisture-keeping effect, non-stickiness and high comfort level after use.
5. The multifunctional efficient compound disinfectant provided by the invention has the advantages of simple preparation process, low equipment requirement and relatively low cost.
6. The multifunctional efficient compound disinfectant provided by the invention is green, environment-friendly, free of toxic and side effects and suitable for a wide range of people.
7. The multifunctional high-efficiency compound disinfectant provided by the invention is convenient and fast to use, is free from washing and can be carried about.
8. The multifunctional disinfectant provided by the invention can kill escherichia coli, staphylococcus aureus, candida albicans and influenza virus pathogenic bacteria within 1min, and the killing rate is up to more than 99.999%.
9. The multifunctional disinfectant provided by the invention can be prepared into a disinfectant suitable for surgical hands, sanitary hands, hard object surfaces, fabrics and other porous object surfaces by adjusting the proportion according to a formula, and has wide application range and strong adaptability.
Detailed Description
The present invention will be described in further detail with reference to the following examples.
Example 1
The multifunctional efficient compound disinfectant is prepared from the following components in percentage by weight:
the preparation method comprises the following steps:
(1) dissolving the solid medicines in the ingredient table in water in advance to prepare aqueous solution with corresponding concentration for later use;
(2) respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, humectant, surfactant, essence and medical ethanol into a reaction kettle with mechanical stirring, and adding pure water to supplement to a certain volume;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) and filtering and subpackaging the uniformly stirred solution to obtain the high-efficiency compound multifunctional disinfectant.
Example 2
The multifunctional efficient compound disinfectant is prepared from the following components in percentage by weight:
the preparation method comprises the following steps:
(1) dissolving the solid medicines in the ingredient table in water in advance to prepare aqueous solution with corresponding concentration for later use;
(2) respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, humectant, surfactant, essence and medical ethanol into a reaction kettle with mechanical stirring, and adding pure water to supplement to a certain volume;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) and filtering and subpackaging the uniformly stirred solution to obtain the high-efficiency compound hand-washing-free disinfectant.
Example 3
The multifunctional efficient compound disinfectant is prepared from the following components in percentage by weight:
| polyhexamethylene biguanide hydrochloride (PHMB) | 0.5％ |
| Didecaalkyl Dimethyl Ammonium Chloride (DDAC) | 0.15％ |
| Polyvinylpyrrolidone (PVP) | 1.5％ |
| Propylene glycol | 2.0％ |
| Alkyl Polyglycoside (APG) | 0.5％ |
| Rose essence | 0.01％ |
| Medical ethanol | 10.0％ |
| Deionized water | Balance of |
The preparation method comprises the following steps:
(1) dissolving the solid medicines in the ingredient table in water in advance to prepare aqueous solution with corresponding concentration for later use;
(2) respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, humectant, surfactant, essence and medical ethanol into a reaction kettle with mechanical stirring, and adding pure water to supplement to a certain volume;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) and filtering and subpackaging the uniformly stirred solution to obtain the high-efficiency compound hand-washing-free disinfectant.
Example 4
The multifunctional efficient compound disinfectant is prepared from the following components in percentage by weight:
| polyhexamethylene biguanide hydrochloride (PHMB) | 1％ |
| Didecaalkyl Dimethyl Ammonium Chloride (DDAC) | 0.2％ |
| Carbomer 934 | 1.5％ |
| Propylene glycol | 2.0％ |
| Cocoamidopropyl betaine (CAB) | 0.5％ |
| Lemon essence | 0.01％ |
| Medical ethanol | 30.0％ |
| Deionized water | Balance of |
The preparation method comprises the following steps:
(1) dissolving the solid medicines in the ingredient table in water in advance to prepare aqueous solution with corresponding concentration for later use;
(2) respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, humectant, surfactant, essence and medical ethanol into a reaction kettle with mechanical stirring, and adding pure water to supplement to a certain volume;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) and filtering and subpackaging the uniformly stirred solution to obtain the high-efficiency compound hand-washing-free disinfectant.
Example 5
The multifunctional efficient compound disinfectant is prepared from the following components in percentage by weight:
| polyhexamethylene biguanide hydrochloride (PHMB) | 2.0％ |
| Didecaalkyl Dimethyl Ammonium Chloride (DDAC) | 0.2％ |
| Polyvinylpyrrolidone (PVP) | 1.5％ |
| Glycerol | 0 |
| Cocoamidopropyl betaine (CAB) | 0.5％ |
| Rose essence | 0.01％ |
| Medical ethanol | 0 |
| Deionized water | Balance of |
The preparation method comprises the following steps:
(1) dissolving the solid medicines in the ingredient table in water in advance to prepare aqueous solution with corresponding concentration for later use;
(2) respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, humectant, surfactant, essence and medical ethanol into a reaction kettle with mechanical stirring, and adding pure water to supplement to a certain volume;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) and filtering and subpackaging the uniformly stirred solution to obtain the high-efficiency compound hand-washing-free disinfectant.
Example 6
The following is an analysis and detection report from a third-party detection mechanism (engel detection technology service (shanghai) ltd.), the test item is a one-time complete skin irritation experiment of a disinfection product, and the sample is the multifunctional high-efficiency compound disinfectant of the embodiment 3.
Sample state: normal appearance and no obvious defect.
The following is an analysis and detection report from a third-party detection organization (invitrogen detection technology service (shanghai) ltd), the detection items are a neutralizer identification test (candida albicans) and a fungus quantitative killing test (candida albicans), and the sample is the multifunctional high-efficiency compound disinfectant of the embodiment 3.
First, equipment
1. Test strains: candida albicans was provided by Invitrogen detection technology service (Shanghai) Inc., 5-6 generation fresh slant cultures.
2. Test samples: the multifunctional high-efficiency compound disinfectant of example 3.
3. Neutralizing agent: D/E broth.
4. And others: 3% organic interferents, standard hard water, etc.
Second, method
1. The detection basis is as follows: the neutralizer identification test and the fungus quantitative kill test were carried out according to the sanitation department disinfection technical Specification (2002 edition) 2.1.1.5.5 and 2.1.1.9.
2. And (3) identification test of a neutralizer: the test samples were exposed to standard hard water at a 1:4 dilution and Candida albicans for 0.5 min. The test temperature was 19-21 deg.C, and the test was repeated 3 times.
3. Quantitative fungus killing test: the action time of the test sample stock solution is 1.25min, 2.5min and 3.75min respectively. The test temperature was 19-21 deg.C, and the test was repeated 3 times.
Three, result in
1. Neutralizer identification test
In 3 repeated experiments, the error rates of three groups of 3, 4 and 5 recovered colonies are respectively 9.87%, 5.62% and 9.46%. The results are shown in Table 2.
TABLE 2 neutralizer identification test results
Note: the negative control group was grown aseptically.
2. Killing effect on test bacteria
After 3 times of repeated tests, the results show that the multifunctional compound disinfectant has killing log values of more than 4.00 for 1.25min, 2.5min and 3.75min of Candida albicans, and the results are shown in Table 3.
TABLE 3 quantitative fungicidal kill test results
Fourth, conclusion
1. After 3 times of repeated tests, the results show that the D/E broth neutralizing agent can neutralize the bactericidal components in the compound disinfectant, and the neutralizing agent and the neutralized product have no obvious influence on the growth of test bacteria and a culture medium. The neutralizing agent is indicated to be suitable for the quantitative killing test of the test sample on the candida albicans.
2. Repeated tests for 3 times show that the hand-washing-free disinfectant has killing log values of more than 4.00 for 1.25min, 2.5min and 3.75min of Candida albicans in suspension.
The above specific examples are only a few embodiments of the present invention, and modifications and variations can be made to the formulation and preparation method of the present invention without departing from the scope of the present invention, and these modifications and variations should also be construed as within the scope of the present invention.
Claims (7)
1. The disinfectant comprises the following main components: 0.01-2.0% of polyhexamethylene biguanide hydrochloride (PHMB), 0.05-0.2% of water-soluble quaternary ammonium salt, 0.1-2.0% of surfactant, 0.05-1.5% of thickening agent, 0.05-2.0% of humectant, 0.001-0.1% of essence, 0-40.0% of medical ethanol and the balance of pure water.
2. The multifunctional efficient compound disinfectant as claimed in claim 1, wherein the amount of the polyhexamethylene biguanide hydrochloride (PHMB) is 0.01-2.0%; the water-soluble quaternary ammonium salt is one of benzalkonium chloride/bromamine, Didecyl Dimethyl Ammonium Chloride (DDAC) and benzethonium bromide/ammonium chloride, and the dosage of the water-soluble quaternary ammonium salt is 0.05-0.2%.
3. The multifunctional high-efficiency compound disinfectant as claimed in claim 1, wherein the surfactant is one or more of polyoxyethylene ether (AEO/JFC/NP/OP/TX), Glyceryl Monostearate (GM), cocamidopropyl betaine 8(CAB) and Alkyl Polyglycoside (APG), and the dosage of the surfactant is 0.1-2.0%.
4. The high-efficiency hand-washing-free compound disinfectant as claimed in claim 1, wherein the thickening agent is one or more of polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyvinylpyrrolidone or carbomer, and the dosage of the thickening agent is 0-1.5%.
5. The multifunctional efficient compound disinfectant as claimed in claim 1, wherein the humectant is one or more selected from glycerin, propylene glycol, aloe vera gel, sodium hyaluronate, carbamide, honey, sodium lactate, sorbitol, pyrrolidone carboxylic acid, and gelatin, and the amount of the humectant is 0-2.0%.
6. The multifunctional efficient compound disinfectant as claimed in claim 1, wherein the essence is one of rose, jasmine, lavender, sandalwood, mint, strawberry and the like in plant essence, and the usage amount of the essence is 0.001-0.1%.
7. The high-efficiency compound disinfectant for hands free as claimed in claim 1, wherein the preparation method comprises the following steps:
(1) dissolving the solid medicines in the ingredient table in water in advance to prepare aqueous solution with corresponding concentration for later use;
(2) respectively adding quantitative polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, surfactant, thickener, humectant, essence and medical ethanol into a reaction kettle with mechanical stirring, and adding pure water to supplement to a certain volume;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 5-60 min;
(4) and filtering and subpackaging the uniformly stirred solution to obtain the multifunctional efficient compound disinfectant.
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