CN112970752B - Environment-friendly efficient surface disinfectant and preparation method thereof - Google Patents
Environment-friendly efficient surface disinfectant and preparation method thereof Download PDFInfo
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- CN112970752B CN112970752B CN202110226558.1A CN202110226558A CN112970752B CN 112970752 B CN112970752 B CN 112970752B CN 202110226558 A CN202110226558 A CN 202110226558A CN 112970752 B CN112970752 B CN 112970752B
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
- A01N37/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof containing the group, wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
Abstract
The invention belongs to the technical field of sanitary disinfection and cleaning, and discloses an environment-friendly efficient surface disinfectant and a preparation method thereof. The environment-friendly efficient surface disinfectant comprises the following raw materials: hydroxypropyl Gemini quaternary ammonium salt surfactant, organic counter ion double-chain quaternary ammonium salt, organic counter ion single-chain quaternary ammonium salt, non-ionic surfactant, cosolvent, chelating agent, pH buffer, aromatic and the balance of distilled water. The environment-friendly efficient surface disinfectant provided by the invention overcomes the problem of bacterial drug resistance of the traditional quaternary ammonium salt disinfectant by compounding three specific novel quaternary ammonium salts, improves the sterilization efficiency by virtue of the synergistic effect of the three quaternary ammonium salts, has broad-spectrum antibacterial property, has a good sterilization effect on spores and viruses, is mild in property, is easy to biodegrade, has no residue in the environment after use, is free from corrosion when being applied to the surface of an object, and has good applicability to the sterilization of metal equipment. The preparation method is simple and easy to implement and has low cost.
Description
Technical Field
The invention relates to the technical field of sanitation and disinfection, and particularly relates to an environment-friendly efficient surface disinfectant and a preparation method thereof.
Background
Microorganisms are ubiquitous in nature, particularly in places where people are densely communicated such as hospitals, hotels and schools, and belong to areas where dust is deposited, bacteria, viruses and propagation are caused, and cross infection between people is easily caused. Because no specific medicine for treating infectious diseases is found at present, the use of a disinfectant to kill pathogens and cut off transmission paths becomes an important measure for preventing and controlling the epidemic of infectious diseases.
The traditional disinfectants at present mainly comprise alcohols, chlorine-containing compounds, peroxy compounds, aldehydes and quaternary ammonium salts. The alcohol disinfectant has a good effect of killing bacteria and viruses, but the strong volatility of the alcohol disinfectant causes the sterilization effect to be not comprehensive enough, and the ethanol is a flammable and explosive substance and is not beneficial to transportation and storage. The chlorine-containing disinfectant is a disinfectant widely used in public places, but has strong corrosivity on metal in the using process, has certain irritation on eyes and respiratory mucosa, and can generate adverse effect on the environment after being used for a long time. The peroxy and aldehyde disinfectants also have the defects of poor stability, strong corrosivity and irritation and the like in the using process, and the application range of the peroxy and aldehyde disinfectants is greatly limited.
As a cationic surfactant disinfectant, the quaternary ammonium salt disinfectant has the advantages of high stability, small irritation, low toxicity and the like, and is widely applied to disinfection of surfaces, skins and mucous membranes of environmental objects at present. The quaternary ammonium salt mainly comprises single-chain quaternary ammonium salt and double-chain quaternary ammonium salt according to the structure, and has the characteristics of high sterilization efficiency and long effective action time. The double-chain quaternary ammonium salt can interfere the synthesis of nucleic acid and protein, and has better killing effect compared with single-chain quaternary ammonium salt, and researches show that the double-chain quaternary ammonium salt has better killing effect on novel coronavirus, can be used for daily prevention and disinfection, and belongs to high-efficiency disinfectants. However, the quaternary ammonium salt disinfectant has a small antibacterial spectrum range, has drug resistance after long-term use of pathogens, and is difficult to kill spore strains when used alone. To improve the above problems, a new generation of quaternary ammonium salt, namely polymeric quaternary ammonium salt, is produced, and most typically, Gemini quaternary ammonium salt surfactant, which is a special bis-N+The head group structure makes the bacteria easier to adsorb and gather on the surface of the bacteria and carry out osmotic destruction, which endows the product with extremely strong killing performance, has no drug resistance problem, and has good compounding and synergistic effect with other surfactants. Compared with the traditional quaternary ammonium salt, the Gemini quaternary ammonium salt surfactant has obvious killing effect on spore strains, but still has the effectTo be further lifted.
The improvement of the sterilization effect through the synergistic effect of the disinfectant combination has become an important research direction in the disinfectant industry. Chinese patent CN101422149B discloses an environment-friendly high-efficiency disinfectant prepared by using coconut oil as a basic raw material, the main sterilization components are traditional single-chain benzyl ammonium chloride and one or more than two halogenated dialkyl dimethyl ammonium which are prepared by using coconut oil as a basic raw material, and the composite disinfectant shows more excellent sterilization effect compared with the traditional single quaternary ammonium salt and is non-toxic and pollution-free. However, the bactericidal component is selected from the traditional quaternary ammonium salt series, and the pathogen still has a certain drug resistance problem. Quaternary ammonium halide salts are somewhat corrosive to surfaces, especially metal surfaces, over extended periods of time and the disinfectant has not proven to kill spore species. Chinese patent CN109169653B discloses a cationic composite disinfectant and application thereof, wherein the bactericidal component comprises a mixture of 1227 and DDAC, an alkyl guanidine mixture and an amino acid surfactant mixture, and the disinfectant also has good disinfection and killing effects and is effective on spore strains. But has the defects of expensive price of part of raw materials, higher disinfection use concentration, long sterilization action time and the like.
Disclosure of Invention
In view of the above, the invention provides an environment-friendly high-efficiency surface disinfectant with low cost and good disinfection effect and a preparation method thereof, so as to solve the problems of expensive raw materials, high disinfection use concentration, poor sterilization effect and the like of the existing surface disinfectant.
In order to achieve the aim, the invention provides an environment-friendly efficient surface disinfectant which is prepared by compounding the following components in percentage by mass:
the balance of distilled water, and the pH value of the high-efficiency surface disinfectant is 6.5-8.0.
Preferably, the structural general formula of the hydroxypropyl Gemini quaternary ammonium salt surfactant is as follows:
wherein R is saturated or unsaturated C7～C15The odd straight-chain alkyl of (1), X is Cl, Br, NO3、 HCOO、CH3COO、CH3CH2COO or CH3C6H4SO3The (p-toluenesulfonic acid group) and the hydroxypropyl Gemini quaternary ammonium salt surfactant are one or a mixture of at least two of the (p-toluenesulfonic acid group) and the hydroxypropyl Gemini quaternary ammonium salt surfactant.
Preferably, the organic counter-ion double-chain quaternary ammonium salt has the following structural general formula:
wherein R is1Is C8～C18Even-numbered linear alkyl of (A), R2Is CH3Or CH2CH2OH, Y is HCOO, CH3COO or CH3CH2COO and the organic counter-ion double-chain quaternary ammonium salt are one or a mixture of at least two of the organic counter-ion double-chain quaternary ammonium salt and the organic counter-ion double-chain quaternary ammonium salt.
Preferably, the structural general formula of the organic counter ion single-chain quaternary ammonium salt is as follows:
wherein R is1Is C8～C18Even-numbered linear alkyl of (A), R2Is CH3Or CH2CH2OH, Y is HCOO, CH3COO or CH3CH2COO and the organic counter ion single-chain quaternary ammonium salt are one or a mixture of at least two of the COO and the organic counter ion single-chain quaternary ammonium salt.
Preferably, the nonionic surfactant is one or a mixture of at least two of fatty alcohol-polyoxyethylene ether or grease-based ethoxy compound.
More preferably, the fatty alcohol-polyoxyethylene ether is R3O(CH2CH2O)nH, wherein R3Is saturated or unsaturated C8～C18The n value of the straight-chain alkyl or branched-chain alkyl is an integer of 1-9.
More preferably, the oil-based ethoxylate is one of coconut oil ethoxylate, soybean oil ethoxylate, palm kernel oil ethoxylate, rapeseed oil ethoxylate, corn oil ethoxylate, cottonseed oil ethoxylate, or castor oil ethoxylate.
Preferably, the cosolvent is one or a mixture of at least two of isopropanol, ethylene glycol or propylene glycol.
Preferably, the chelating agent is one or a mixture of at least two of ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), aminotrimethylene phosphoric Acid (ATMP) or a sodium salt thereof.
Preferably, the pH buffering agent is sodium dihydrogen phosphate or disodium hydrogen phosphate.
Preferably, the fragrance is an oil-soluble or water-soluble fragrance that does not contain anionic components.
The invention also aims to provide a preparation method of the environment-friendly high-efficiency surface disinfectant, which comprises the following steps:
(1) preparing raw materials according to a mixture ratio;
(2) adding the raw material cosolvent and distilled water accounting for 60 percent of the total mass into a batching container, heating and uniformly stirring;
(3) sequentially adding a hydroxypropyl Gemini quaternary ammonium salt surfactant, an organic counter ion double-chain quaternary ammonium salt, an organic counter ion single-chain quaternary ammonium salt and a non-ionic surfactant, uniformly stirring, and cooling after complete dissolution;
(4) adding a chelating agent, a pH buffering agent, an aromatic and the balance of distilled water into a batching container, and uniformly stirring to obtain the environment-friendly high-efficiency surface disinfectant.
Preferably, in the step (2), the material mixing container is heated to 50-70 ℃ and then stirred for 5-10 min.
Preferably, the stirring time in the step (3) is 10-25 min, and the container is cooled to 25-40 ℃ after the raw materials are completely dissolved by stirring.
Preferably, the stirring time in the step (4) is 10-20 min.
The invention has the following beneficial effects:
(1) the environment-friendly efficient surface disinfectant provided by the invention is prepared by compounding a plurality of disinfecting and sterilizing components, can exert the synergistic interaction of the components to the greatest extent, has the advantages of high disinfecting and sterilizing efficiency, wide sterilizing spectrum, good disinfecting and sterilizing effect and the like, particularly has good killing effect on spores, has good foamability, can be uniformly covered on the surface of an acting object, and eliminates a disinfecting blind area caused by uneven spraying.
(2) The hydroxypropyl Gemini quaternary ammonium salt surfactant, the organic counter ion double-chain quaternary ammonium salt and the organic counter ion single-chain quaternary ammonium salt are novel quaternary ammonium salts, and compared with the traditional quaternary ammonium salt, the sterilization effect and the compounding synergy are better, the three specific novel quaternary ammonium salts overcome the drug resistance problem of the traditional quaternary ammonium salt disinfectant, the disinfectant is mild in property and easy to biodegrade, no environmental residue is left after use, and the characteristic of greenness is reflected.
(3) The high-efficiency surface disinfectant provided by the invention is non-toxic and non-irritant, and has no corrosion to the surfaces of metal steel such as stainless steel, carbon steel and the like.
(4) The high-efficiency surface disinfectant provided by the invention has good stability, low concentration of sterilization effect and low cost, is suitable for large-scale industrial production, can be widely applied to disinfection and cleaning of public gathering places such as hospitals, hotels, schools and the like, and can also be used as a sterilization disinfectant of medical instruments.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The environment-friendly surface disinfectant comprises the following components: 1, 3-bis (octylacylpropyldimethylammonium chloride) isopropanol: 30.0g, didecyl dimethyl ammonium formate: 15.0g, monododecyltrimethylammonium formate: 2.5g of nonionic surfactant C12H25O(CH2CH2O)3H: 3.0g, isopropyl alcohol: 20.0g, EDTA: 0.5g, disodium hydrogen phosphate: 2.0g, rose essence: 0.5g and the balance of distilled water.
The preparation method comprises the following steps:
600.0g of distilled water and 20.0g of isopropanol are weighed into a batching vessel, heated to 50 ℃ and stirred for 5min, after which 30.0g of 1, 3-di (octylacylpropyldimethylammonium chloride) isopropanol, 15.0g of didecyldimethylammonium formate, 2.5g of monododecyltrimethylammonium formate and 3.0g of C are added in succession12H25O(CH2CH2O)3H, stirring for 10min, and cooling to 25 ℃ after complete dissolution; adding 0.5g of EDTA, 2.0g of disodium hydrogen phosphate, 0.5g of rose essence and 326.5g of distilled water into a batching container, stirring for 10min, and filling to obtain the high-efficiency surface disinfectant.
Example 2
The environment-friendly surface disinfectant comprises the following components: 1, 3-bis (lauroyl propyl dimethyl ammonium chloride) isopropyl alcohol 20.0g, dioctyldimethylammonium formate: 18.0g, isooctyltrimethylammonium formate: 2.0g of nonionic surfactant C12H25O(CH2CH2O)7H: 5.0g, ethylene glycol: 15.0g, EDTA: 2.0g, sodium dihydrogen phosphate: 1.5g, jasmine essence: 0.5g and the balance of distilled water.
The preparation method comprises the following steps:
600.0g of distilled water and 15.0g of ethylene glycol are weighed into a batching vessel, heated to 60 ℃ and stirred for 5min, after which 20.0g of 1, 3-di (lauroyl propyl dimethyl ammonium chloride) isopropanol and 18.0g of dioctyldimethyl ammonium formate are added in succession2.0g of monooctyltrimethylammonium formate and 5.0g of C12H25O(CH2CH2O)7H, stirring for 20min, cooling to 30 ℃ after complete dissolution, adding 2.0g of EDTA, 1.5g of sodium dihydrogen phosphate, 0.5g of jasmine essence and 344.5g of distilled water into a batching container, stirring for 15min, and filling to obtain the high-efficiency surface disinfectant.
Example 3
The environment-friendly surface disinfectant comprises the following components: 1, 3-bis (lauroylpropyl dimethyl ammonium monochloro monobromide) isopropanol: 25.0g, didecyldimethylammonium acetate: 5.0g, ammonium monocetyl trimethyl acetate: 5.0g of nonionic surfactant C12H25O(CH2CH2O)9H: 8.0g, isopropanol 5.0g, ethylene glycol: 10.0g, NTA: 2.0g, sodium dihydrogen phosphate: 1.0g, lemon essence: 1.0g and the balance distilled water.
The preparation method comprises the following steps:
600.0g of distilled water, 5.0g of isopropanol and 10.0g of ethylene glycol are weighed into a batching vessel, heated to 70 ℃ and stirred for 7min, after which 25.0g of 1, 3-bis (lauroyl propyl dimethyl ammonium monochloro monobromide) isopropanol, 5.0g of didecyl dimethyl ammonium acetate, 5.0g of monocetyl trimethyl ammonium acetate and 8.0g of C are added in succession12H25O(CH2CH2O)9H, stirring for 25min, cooling to 30 ℃ after complete dissolution, adding 2.0g of NTA, 1.0g of sodium dihydrogen phosphate, 1.0g of lemon essence and 341.0g of distilled water into a batching container, stirring for 15min, and filling to obtain the high-efficiency surface disinfectant.
Example 4
The environment-friendly surface disinfectant comprises the following components: 1, 3-bis (palmitoyl propyl dimethyl ammonium chloride) isopropanol: 10.0g, didecylmethylhydroxyethylammonium acetate: 20.0g, ammonium monododecyldimethylhydroxyethylformate: 2.0g, nonionic surfactant: isomeric C13H27O(CH2CH2O)7H: 6.0g, isopropyl alcohol: 30.0g, EDTA-2 Na: 2.5g, disodium hydrogen phosphate: 5.0g, lavender essence: 1.5g and the balance of distilled water.
The preparation method comprises the following steps:
600.0g of distilled water and 30.0g of isopropanol are weighed into a batching vessel, heated to 70 ℃ and stirred for 10min, after which 10.0g of 1, 3-bis (palmitoylpropyldimethylammonium chloride) isopropanol, 20.0g of didecylmethylhydroxyethylammonium acetate, 2.0g of monododecyldimethylhydroxyethylammonium formate and 6.0g of isomeric C13H27O(CH2CH2O)7H, stirring for 15min, and cooling to 40 ℃ after complete dissolution; adding 2.5g of EDTA-2Na, 5.0g of disodium hydrogen phosphate, 1.5g of lavender essence and 290g of distilled water into a batching container, stirring for 20min, and filling to obtain the high-efficiency surface disinfectant.
Example 5
The environment-friendly surface disinfectant comprises the following components: 1, 3-bis (octyl/decylacylpropyldimethyl monochloro-p-toluenesulfonate) isopropanol: 50.0g, dipalmityl methyl hydroxyethyl ammonium formate: 1.0g, ammonium monooctyldimethyl hydroxyethyl formate: 1.0g, nonionic surfactant: coconut oil ethoxylate: 2.0g, propylene glycol: 10.0 g; EDTA-2 Na: 5.0g, disodium hydrogen phosphate: 0.5g, lily essence: 2.0g and the balance distilled water.
The preparation method comprises the following steps:
weighing 600.0g of distilled water and 10.0g of propylene glycol, adding into a batching container, heating to 50 ℃, and stirring for 5 min; then adding 50.0g of 1, 3-bis (octyl/decyl acyl propyl dimethyl monochloro-p-toluene ammonium sulfonate) isopropanol, 1.0g of dipalmityl methyl hydroxyethyl ammonium formate, 1.0g of mono-octyl dimethyl hydroxyethyl ammonium formate and 2.0g of coconut oil ethoxylate in sequence, stirring for 20min, cooling to 30 ℃ after complete dissolution, adding 5.0g of EDTA-2Na, 0.5g of disodium hydrogen phosphate, 2.0g of lily essence and 344g of distilled water into a batching container, stirring for 10min, and filling to obtain the high-efficiency surface disinfectant.
Example 6
The environment-friendly surface disinfectant comprises the following components: 1, 3-bis (lauroylpropyldimethyl ammonium monochlorohydrite) isopropanol: 10.0g, didecyldimethylammonium formate: 20.0g, ammonium monododecyldimethylhydroxyethylacetate: 5.0g, nonionic surfactant: soybean oil ethoxylate: 5.0g, propylene glycol: 10.0g, NTA-3 Na: 1.0g, sodium dihydrogen phosphate: 0.5g, lemon essence: 1.0g and the balance distilled water.
The preparation method comprises the following steps:
weighing 600.0g of distilled water and 10.0g of propylene glycol, adding into a batching container, heating to 50 ℃, and stirring for 5 min; then, 10.0g of 1, 3-bis (lauroyl propyl dimethyl ammonium monochloride) isopropanol, 20.0g of didecyl dimethyl ammonium formate, 5.0g of monododecyl dimethyl hydroxyethyl ammonium acetate and 5.0g of soybean oil ethoxylate are sequentially added, stirred for 15min, cooled to 35 ℃ after complete dissolution, added with 1.0g of NTA-3Na, 0.5g of sodium dihydrogen phosphate, 1.0g of lemon essence and 350g of distilled water, stirred for 10min and filled to obtain the high-efficiency surface disinfectant.
Example 7
The environment-friendly surface disinfectant comprises the following components: 1, 3-bis (palmitoylpropyldimethylmonochloroacetic acid ammonium) isopropanol: 35.0g, didodecylmethylhydroxyethylammonium propionate: 10.0g, monododecyldimethylhydroxyethylammonium propionate: 2.0g, nonionic surfactant: palm kernel oil ethoxylate: 4.0g, isopropyl alcohol: 15.0g, propylene glycol: 10.0g, ATMP: 2.0g, sodium dihydrogen phosphate: 2.5g and the balance distilled water.
The preparation method comprises the following steps:
weighing 600.0g of distilled water, 15.0g of isopropanol and 10.0g of propylene glycol, adding the mixture into a batching container, heating the mixture to 60 ℃, stirring the mixture for 7min, then sequentially adding 35.0g of 1, 3-di (palmitoyl propyl dimethyl ammonium monochloroacetate) isopropanol, 2.0g of didodecyl methyl hydroxyethyl ammonium propionate, monododecyl dimethyl hydroxyethyl ammonium propionate and 4.0g of palm kernel oil ethoxylate, stirring the mixture for 20min, cooling the mixture to 40 ℃ after complete dissolution, adding 2.0g of ATMP, 2.5g of sodium dihydrogen phosphate and 313.5g of distilled water into the batching container, stirring the mixture for 15min, and filling the mixture to obtain the high-efficiency surface disinfectant.
Example 8
The environment-friendly surface disinfectant comprises the following components: 1, 3-bis (octylacylpropyldimethylmonochloropropionamide) isopropanol: 10.0g, didecyldimethylammonium acetate: 20.0g, oleyl dimethyl hydroxyethyl ammonium acetate: 5.0g, nonionic surfactant: corn oil ethoxylate: 10.0g, ethylene glycol: 15.0g, ATMP-5 Na: 3.0g, disodium hydrogen phosphate: 1.0g, lemon essence: 0.5g and the balance of distilled water.
The preparation method comprises the following steps:
weighing 600.0g of distilled water and 15.0g of ethylene glycol, adding the distilled water and the ethylene glycol into a batching container, heating the mixture to 60 ℃, stirring the mixture for 10min, then sequentially adding 10.0g of 1, 3-di (octylacylpropyldimethylmonochloromethylammonium monochloropropionate) isopropanol, 20.0g of didecyldimethylammonium acetate, 5.0g of oleyldimethylammonium glycolate and 10.0g of corn oil ethoxylate, stirring the mixture for 12min, cooling the mixture to 30 ℃ after the mixture is completely dissolved, adding 3.0g of ATMP-5Na, 1.0g of disodium hydrogen phosphate, 0.5g of lemon essence and 335.5g of distilled water into the batching container, stirring the mixture for 10min, and filling the mixture to obtain the high-efficiency surface disinfectant.
Example 9
The environment-friendly surface disinfectant comprises the following components: 1, 3-bis (oleyl acylpropyl dimethyl monochloro ammonium monopropionate) isopropanol: 30.0g, dioctylmethylhydroxyethylammonium acetate: 10.0g, octyltrimethylammonium propionate: 2.0g, nonionic surfactant: castor oil ethoxylate: 8.0g, isopropyl alcohol: 25.0g, NTA-3 Na: 5.0g, sodium dihydrogen phosphate: 3.0g, rose essence: 1.5g and the balance distilled water.
The preparation method comprises the following steps:
weighing 600.0g of distilled water and 25.0g of isopropanol, adding the distilled water and the isopropanol into a batching container, heating the mixture to 70 ℃, stirring the mixture for 5min, then sequentially adding 30.0g of 1, 3-di (oleyl acyl propyl dimethyl ammonium monochloropropionate) isopropanol, 10.0g of dioctylmethylhydroxyethylammonium acetate, 2.0g of octyltrimethylammonium propionate and 8.0g of castor oil ethoxylate, stirring the mixture for 20min, cooling the mixture to 40 ℃ after the mixture is completely dissolved, adding 5.0g of NTA-3Na, 3.0g of sodium dihydrogen phosphate, 1.5g of rose essence and 315.5g of distilled water into the batching container, stirring the mixture for 15min, and filling the mixture to obtain the high-efficiency surface disinfectant.
Example 10
The environment-friendly surface disinfectant comprises the following components: 1, 3-bis (lauroyl propyl dimethyl monochloro ammonium nitrate) isopropanol: 5.0g, didecyldimethylammonium propionate: 20.0g, octyl dimethyl hydroxyethyl ammonium acetate: 5.0g, ethylene glycol: 10.0g, NTA: 2.5g, disodium hydrogen phosphate: 2.5g, lavender essence: 2.0g and the balance distilled water.
The preparation method comprises the following steps:
weighing 600.0g of distilled water and 10.0g of ethylene glycol, adding the distilled water and the ethylene glycol into a batching container, heating the mixture to 50 ℃, stirring the mixture for 5min, then sequentially adding 5.0g of 1, 3-bis (lauroyl propyl dimethyl monochloro ammonium nitrate) isopropanol, 20.0g of didecyl dimethyl ammonium propionate and 5.0g of octyl dimethyl hydroxyethyl ammonium acetate, stirring the mixture for 10min, cooling the mixture to 25 ℃ after the mixture is completely dissolved, adding 2.5g of NTA, 2.5g of disodium hydrogen phosphate, 2.0g of lavender essence and 353g of distilled water into the batching container, stirring the mixture for 10min, and filling the mixture to obtain the high-efficiency surface disinfectant.
Example 11
The environment-friendly surface disinfectant comprises the following components: 1, 3-bis (palmitoylpropyldimethylmonochloroacetic acid ammonium) isopropanol: 40.0g, ammonium didecylmethylhydroxyethylformate: 8.0g, hexadecyl dimethyl hydroxyethyl ammonium propionate: 1.5g, nonionic surfactant: cottonseed oil ethoxylate: 5.0g, isopropyl alcohol: 25.0g, ATMP: 1.0g, disodium hydrogen phosphate: 5.0g, jasmine essence: 1.0g and the balance distilled water.
The preparation method comprises the following steps:
weighing 600.0g of distilled water and 25.0g of isopropanol, adding the distilled water and the isopropanol into a batching container, heating the mixture to 70 ℃, stirring the mixture for 7min, then sequentially adding 40.0g of 1, 3-bis (palmitoylpropyldimethyl ammonium monochloroacetate) isopropanol, 8.0g of ammonium didecylmethyl hydroxyethyl formate, 1.5g of hexadecyl dimethyl ammonium hydroxyethyl propionate and 5.0g of cottonseed oil ethoxylate, stirring the mixture for 25min, cooling the mixture to 30 ℃ after the mixture is completely dissolved, adding 1.0g of ATMP, 5.0g of disodium hydrogen phosphate, 1.0g of jasmine essence and 312.5g of distilled water into the batching container, stirring the mixture for 10min, and filling the mixture to obtain the high-efficiency surface disinfectant.
Example 12
The environment-friendly surface disinfectant comprises the following components: 1, 3-bis (lauroylpropyldimethylmonochloropropionamide) isopropanol: 25.0g, didodecyldimethylammonium propionate: 1.0g, oleyl trimethyl ammonium formate: 5.0g, nonionic surfactant: soybean oil ethoxylate: 8.0g, ethylene glycol: 20.0g, ATMP-5 Na: 5.0g, sodium dihydrogen phosphate: 2.0g, lily essence: 1.5g and the balance distilled water.
The preparation method comprises the following steps:
weighing 600.0g of distilled water and 20.0g of ethylene glycol, adding the distilled water and the ethylene glycol into a batching container, heating the mixture to 60 ℃, stirring the mixture for 7min, then sequentially adding 25.0g of 1, 3-bis (lauroyl propyl dimethyl ammonium monochloropropionate) isopropanol, 1.0g of didodecyl dimethyl ammonium propionate, 5.0g of oil-based trimethyl ammonium formate and 8.0g of soybean oil ethoxylate, stirring the mixture for 10min, cooling the mixture to 40 ℃ after the mixture is completely dissolved, adding 5.0g of ATMP-5Na, 2.0g of sodium dihydrogen phosphate, 1.5g of lily essence and 327.5g of distilled water into the batching container, stirring the mixture for 12min, and filling the mixture to obtain the high-efficiency surface disinfectant.
To further verify the technical effect of the environment-friendly and efficient surface disinfectant provided by the invention, the inventor conducts experimental tests on the 12 examples according to the requirements related to the second part 2.2.3 test in the disinfection technical Specification (2002 edition).
1. Product appearance test
The packaged disinfectant product is placed in a 37 ℃ thermostat for 3 months, and the appearance of the disinfectant product of the embodiment 1-12 has no color change, no sediment and suspended matters, and is still colorless and transparent.
2. Stability test of active ingredient quaternary ammonium salt of product
The packaged disinfectant product was placed in a 37 ℃ incubator for 3 months, the change in the content of the quaternary ammonium salt component of the disinfectant product was measured, each example was tested in triplicate, the average was taken, and the test results are shown in table 1.
TABLE 1 stability test of quaternary ammonium salt content in examples 1 to 12
The test result shows that: in the examples 1-12, after being placed at 37 ℃ for 3 months, the content reduction rate of the quaternary ammonium salt serving as the active ingredient is lower than 3 percent and is far less than 10 percent of the requirement in disinfection technical specification (2002 edition), and the standard regulation that the effective period of the product is 2 years is met.
3. Sterilization test of disinfectant products
The disinfectant products of examples 1-6 were tested for bactericidal and disinfectant effects by suspension quantification methods according to the requirements associated with the second part 2.1.1 test in the technical Specification for Disinfection (2002 edition).
TABLE 2 germicidal efficacy of the disinfectant solutions of examples 1 to 6 (action time: 10min)
The test result shows that: according to the evaluation regulation (the killing log value of a bacterial propagule is more than or equal to 5, and the killing log value of fungi and viruses is more than or equal to 4) of a suspension quantitative sterilization test in the disinfection technical specification (2002 edition) of 2.1.1.1, the disinfectant is judged to be qualified, when the disinfection action time is 10min, the disinfectant prepared in the embodiment 1-6 has excellent killing effects on staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and candida albicans (fungi) under the concentration of the dilution degree of 1: 500 and 1: 1000, and the evaluation standard of the disinfectant on the qualification of the killing rate is reached; when the compound is used for poliovirus and bacillus subtilis, the disinfection and killing effect can be achieved at the concentration of 1: 100 by dilution.
4. Skin irritation test and acute oral toxicity test
(1) Single skin irritation test
The test result shows that: the disinfectant stock solutions of examples 1 and 6 were non-irritating to new zealand rabbits in a single whole skin test.
(2) Acute oral toxicology test
The test result shows that: during the test on the disinfectant stock solutions of examples 1 and 6, all the test animals did not show significant toxic symptoms and death within the 14-day observation period; acute oral toxicity LD of disinfectant stock solution on SPF-grade KM mice50More than 5000mg/kg BW, which belongs to the actual nontoxic level.
5. Corrosion test of metals
Examples 1-6 were tested for metal corrosion according to the requirements associated with the second part 2.2.4 of the test in the Disinfection Specification (2002 edition) with stainless steel, carbon steel, copper and aluminum as test objects and the results are shown in Table 3.
TABLE 3 Corrosion test of disinfectants on metals (dilution: 1: 100)
The test result shows that: according to the classification standard for metal corrosivity in section 2.2.4 of the specification for disinfection (2002), when the disinfectant prepared in examples 1-6 of the present invention is diluted at a dilution of 1: 100, the corrosion rates for stainless steel, carbon steel, copper and aluminum are all less than 0.01mm/a, all of which are the lowest corrosion levels, and are assigned to the substantially non-corrosive levels.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. An environment-friendly efficient surface disinfectant is characterized by being prepared by compounding the following components in percentage by mass:
the balance of distilled water, wherein the pH value of the high-efficiency surface disinfectant is 6.5-8.0;
the general structural formula of the hydroxypropyl Gemini quaternary ammonium salt surfactant is as follows:
wherein R is saturated or unsaturated C7～C15The odd straight-chain alkyl of (1), X is Cl, Br, NO3、HCOO、CH3COO、CH3CH2COO or CH3C6H4SO3The hydroxypropyl Gemini quaternary ammonium salt surfactant is one or a mixture of at least two of the hydroxypropyl Gemini quaternary ammonium salt surfactant;
the structural general formula of the organic counter ion double-chain quaternary ammonium salt is as follows:
wherein R is1Is C8～C18Even-numbered linear alkyl of (A), R2Is CH3Or CH2CH2OH, Y is HCOO, CH3COO or CH3CH2COO, wherein the organic counter ion double-chain quaternary ammonium salt is one or a mixture of at least two of the organic counter ion double-chain quaternary ammonium salts;
the structural general formula of the organic counter ion single-chain quaternary ammonium salt is as follows:
wherein R is1Is C8～C18Even-numbered linear alkyl of (A), R2Is CH3Or CH2CH2OH, Y is HCOO, CH3COO or CH3CH2COO, wherein the organic counter ion single-chain quaternary ammonium salt is one or a mixture of at least two of the organic counter ion single-chain quaternary ammonium salts.
2. The environment-friendly high-efficiency surface disinfectant as claimed in claim 1, wherein the non-ionic surfactant is one or a mixture of at least two of fatty alcohol-polyoxyethylene ether or grease-based ethoxy compound;
the fatty alcohol-polyoxyethylene ether is R3O(CH2CH2O)nH, wherein R3Is saturated or unsaturated C8～C18The n value of the straight-chain alkyl or branched-chain alkyl is an integer of 1-9;
the oil-based ethoxylate is one of coconut oil ethoxylate, soybean oil ethoxylate, palm kernel oil ethoxylate, rapeseed oil ethoxylate, corn oil ethoxylate, cottonseed oil ethoxylate, or castor oil ethoxylate.
3. The environment-friendly high-efficiency surface disinfectant as claimed in claim 1, wherein the cosolvent is one or a mixture of at least two of isopropanol, ethylene glycol or propylene glycol.
4. The environment-friendly high-efficiency surface disinfectant as claimed in claim 1, wherein the chelating agent is one or a mixture of at least two of ethylenediamine tetraacetic acid, nitrilotriacetic acid, aminotrimethylene phosphoric acid or sodium salts thereof.
5. The environment-friendly high-efficiency surface disinfectant as claimed in claim 1, wherein the pH buffering agent is sodium dihydrogen phosphate or disodium hydrogen phosphate.
6. The environment-friendly high-efficiency surface disinfectant according to claim 1, wherein the aromatic agent is an oil-soluble or water-soluble aromatic agent containing no anionic component.
7. The preparation method of the environment-friendly high-efficiency surface disinfectant as claimed in any one of claims 1 to 6, comprising the following steps:
(1) preparing raw materials according to a mixture ratio;
(2) adding the raw material cosolvent and distilled water accounting for 60 percent of the total mass into a batching container, heating and uniformly stirring;
(3) sequentially adding a hydroxypropyl Gemini quaternary ammonium salt surfactant, an organic counter ion double-chain quaternary ammonium salt, an organic counter ion single-chain quaternary ammonium salt and a non-ionic surfactant, uniformly stirring, and cooling after complete dissolution;
(4) adding a chelating agent, a pH buffering agent, an aromatic and the balance of distilled water into a batching container, and uniformly stirring to obtain the environment-friendly high-efficiency surface disinfectant.
8. The preparation method of the environment-friendly efficient surface disinfectant as claimed in claim 7, wherein the batching container is heated to 50-70 ℃ in the step (2), and the stirring time is 5-10 min.
9. The preparation method of the environment-friendly efficient surface disinfectant as claimed in claim 7, wherein the stirring time in the step (3) is 10-25 min, and the temperature of the container is reduced to 25-40 ℃ after the raw materials are completely dissolved.
10. The preparation method of the environment-friendly efficient surface disinfectant as claimed in claim 7, wherein the stirring time in the step (4) is 10-20 min.
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