CN113854290A - Long-acting lasting biguanide compound disinfectant and preparation method thereof - Google Patents
Long-acting lasting biguanide compound disinfectant and preparation method thereof Download PDFInfo
- Publication number
- CN113854290A CN113854290A CN202111184554.8A CN202111184554A CN113854290A CN 113854290 A CN113854290 A CN 113854290A CN 202111184554 A CN202111184554 A CN 202111184554A CN 113854290 A CN113854290 A CN 113854290A
- Authority
- CN
- China
- Prior art keywords
- biguanide
- disinfectant
- long
- acting
- tween
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
Abstract
The application particularly discloses a long-acting lasting biguanide compound disinfectant and a preparation method thereof. A long-acting durable biguanide composite disinfectant comprises, by weight, 0.1-0.3% of biguanide salt, 2-4% of quaternary ammonium salt, 0.8-1.4% of povidone iodine, 0.1-0.2% of tween, 0.08-0.12% of polyethylene glycol, 0.05-0.15% of sodium dodecyl sulfate and 0.05-0.15% of dodecyl betaine. The preparation method comprises the following steps: s1, dissolving the biguanide disinfectant and the quaternary ammonium salt disinfectant in water, and uniformly stirring; s2 adding povidone iodine, tween, polyethylene glycol, sodium dodecyl sulfate and dodecyl betaine into the solution obtained in S1, and stirring at normal temperature for 50-80 min; s3 adding water into the solution obtained in S2, adding a buffering agent, and adjusting the pH value to 3.7-4.2 to obtain a finished product. The long-acting lasting biguanide compound disinfectant can be used for surface sterilization of common objects and has the advantage of long-acting lasting sterilization.
Description
Technical Field
The application relates to the technical field of disinfectants, in particular to a long-acting lasting biguanide composite disinfectant and a preparation method thereof
Background
The disinfectant products commonly used in the market mainly comprise chlorine-containing disinfectants, quaternary ammonium salt disinfectants, alcohol disinfectants, iodine-containing disinfectants and peroxide disinfectants. However, high concentration chlorine-containing disinfectants are corrosive and irritant, causing harm to human bodies and ecological environments; the quaternary ammonium salt disinfectant has the disadvantages of accumulated toxicity, non-ideal effect of killing partial microorganisms and the like, the killing effect is relatively low, and the disinfection effect is easily influenced by organic matters. Due to strong oxidation and fat dissolution effects, the alcohol disinfectant is easy to cause allergic dermatitis, water loss and cracking pain after being used for disinfecting hands and skins for a long time, is inflammable and explosive, and is easy to cause fire accidents when being mistakenly used for space spraying; although the peroxide disinfectant has good killing effect, the peroxide disinfectant has unstable property, is easy to decompose and is easy to explode in the transportation and storage processes.
Biguanide disinfectants are widely used for disinfection of medicines, foods and other places because of their advantages of being colorless, tasteless, nontoxic, free of side effects, environment-friendly and the like. The water solution of the water-soluble organic acid is positively charged and is easy to be adsorbed on the surfaces of bacteria and viruses. So that the cell membrane can not be separated and propagated, and loses activity, and simultaneously, the structure of the cell membrane is collapsed, so that the cell membrane is cracked, the energy metabolism of microorganisms is damaged, and the activity of bacteria and viruses is lost. In addition, the sterilization mechanism is independent of the form and the type of the microorganism, and even the variety or the variation of the microorganism does not influence the exertion of the efficacy. The existing biguanide disinfectants in the market are mainly single-component biguanide disinfectants, and the single-component biguanide disinfectants are high in required concentration, so that the defects of high cost and high price and unstable sterilization effect exist. Research shows that the biguanide disinfectant is compounded to effectively reduce the use concentration of the medicament, improve the sterilization performance of the product and reduce the product cost.
However, even if the existing compound biguanide disinfectant is compounded with ethanol, quaternary ammonium salt and the like, the improvement of the sterilization effect is realized, and the problems of short sterilization time effect, non-lasting antibiosis, repeated sterilization and disinfection are still existed, so that the consumption of a large amount of medicaments and labor resources is caused.
Disclosure of Invention
In order to prolong the sterilization time of the compound biguanide disinfectant, the application provides a long-acting lasting biguanide compound disinfectant and a preparation method thereof.
In a first aspect, the application provides a long-acting lasting biguanide compound disinfectant, which adopts the following technical scheme: a long-acting durable biguanide composite disinfectant comprises, by weight, 0.1-0.3% of biguanide salt, 2-4% of quaternary ammonium salt, 0.8-1.4% of povidone iodine, 0.1-0.2% of tween, 0.08-0.12% of polyethylene glycol, 0.05-0.15% of sodium dodecyl sulfate and 0.05-0.15% of dodecyl betaine.
Preferably, the weight ratio of the sodium dodecyl sulfate to the dodecyl betaine is 1: 1.
Through the technical scheme, when the lauryl betaine and the lauryl sodium sulfate are added into the disinfectant and are matched with the disinfectant in the weight ratio, the lauryl sodium sulfate and the lauryl betaine can promote effective components in the disinfectant to be: the biguanide salt, the quaternary ammonium salt and the povidone iodine are dispersed in the disinfectant more uniformly, and the use stability of the disinfectant is improved.
On the other hand, the mutual matching of the sodium dodecyl sulfate and the dodecyl betaine enables the disinfectant to form a stable film layer after being sprayed on the surface of an object and be attached to the surface of the object to be applied with the disinfectant, thereby improving the long-acting sterilization performance of the disinfectant.
Particularly, when the ratio of the sodium dodecyl sulfate to the betaine is 1:1, a film layer formed after the disinfectant is dried is more stable. The effective components in the disinfectant can be attached to the surface of the object to be applied for a longer time.
The disinfectant has the advantages that the biguanide salt, the quaternary ammonium salt and the povidone iodine are selected for proportioning, the consumption of the biguanide salt is effectively reduced, the disinfection performance of the disinfectant is improved, and the main sterilization components are the biguanide salt, the quaternary ammonium salt and the povidone iodine; the biguanide salt and the quaternary ammonium salt can directly play a broad-spectrum sterilization role, the povidone iodine gradually releases elementary iodine, and the elementary iodine is matched with the biguanide salt and the quaternary ammonium salt, so that the long-acting sterilization performance of the disinfectant is effectively improved.
In a preferred embodiment of the present application, the weight percentage of sodium lauryl sulfate is 0.1% and the weight percentage of lauryl betaine is 0.1%.
By adopting the technical scheme, when the proportion of 0.1 wt% of the sodium dodecyl sulfate and the dodecyl betaine is selected, the film-forming adhesive force of the disinfectant after drying is stronger, and the bactericidal performance of the disinfectant is longer-acting.
Preferably, the long-acting lasting biguanide composite disinfectant comprises, by weight, 0.2% of biguanide salt, 3% of quaternary ammonium salt and 1% of povidone iodine.
Through the technical scheme, when the using amount of the biguanide salt is 0.1-0.2%, the sterilizing effect of the disinfectant is increased along with the increase of the using amount of the biguanide salt. When the amount of the biguanide salt is more than 0.2%, the bactericidal effect is substantially maintained, but the increase in the amount of the biguanide salt leads to an increase in cost, so that when the amount of the biguanide salt is 0.2%, the production cost can be reduced while maintaining a high bactericidal effect.
Similarly, when the dosage of the quaternary ammonium salt is 2% -3%, the sterilizing effect of the disinfectant is increased along with the increase of the dosage of the quaternary ammonium salt, and when the dosage of the quaternary ammonium salt is 3% -4%, the sterilizing effect of the disinfectant is not obviously improved.
When the biguanide salt and the quaternary ammonium salt are used in combination, if the usage amount of the biguanide salt is more than 3 percent, the sterilizing effect of the disinfectant is also reduced to a certain extent; similarly, if the quaternary ammonium salt is used in an amount of more than 4%, the sterilizing effect of the disinfectant is reduced.
When the dosage of the povidone iodine is 0.8 to 1 percent, the sterilizing effect of the disinfectant is increased along with the dosage of the povidone iodine; when the consumption of the povidone iodine is 1 to 1.2 percent, the sterilizing effect of the disinfectant is basically maintained inconveniently, while when the consumption of the povidone iodine is more than 1.2 percent, the performance of the disinfectant begins to be reduced, and when the consumption of the povidone iodine is more than 1.4 percent, the sterilizing performance and the adhesion performance of the disinfectant are obviously reduced. The main reason is that the main bactericidal substance of povidone iodine is free iodine, and the concentration of free iodine in the solution gradually decreases as the concentration of povidone iodine increases.
Preferably, the biguanide salt is selected from any one or more of polyhexamethylene biguanide hydrochloride, polyaminopropyl biguanide hydrochloride, chlorhexidine acetate, and chlorhexidine gluconate.
Preferably, the quaternary ammonium salt is selected from one or more of didecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium chloride, benzalkonium bromide and benzalkonium chloride.
Preferably, the tween is one or more of tween 20, tween 60 and tween 80.
Preferably, the degree of polymerization of the polyethylene glycol is 200-2000.
By adopting the technical scheme, in a second aspect, the application provides a preparation method of a long-acting lasting biguanide compound disinfectant, which adopts the following technical scheme: a process for the preparation of a long acting biguanide complex disinfectant according to claims 1 to 8, wherein: the method comprises the following steps:
s1, dissolving the biguanide disinfectant and the quaternary ammonium salt disinfectant in water, and uniformly stirring;
s2 adding povidone iodine, tween, polyethylene glycol, sodium dodecyl sulfate and dodecyl betaine into the solution obtained in S1, and stirring at normal temperature for 50-80 min;
s3 adding water into the solution obtained in S2, adding a buffering agent, and adjusting the pH value to 3.7-4.2 to obtain a finished product.
Preferably, the buffer is a phosphate buffer, and the pH value is 5.5.
Preferably, in the step S3, when the pH is adjusted, one or more of ethylenediaminetetraacetic acid, citric acid, and trichloroacetic acid is used for the adjustment.
In summary, the present application has the following beneficial effects:
1. because the complex formulation of the sodium dodecyl sulfate and the dodecyl betaine is adopted, the adhesive property of the disinfectant is improved, and the long-acting property of the disinfectant is improved.
2. The compound of the biguanide salt, the quaternary ammonium salt and the povidone iodine is adopted in the application, so that the sterilizing effect of the disinfectant can be improved, and the using amounts of the biguanide salt and the quaternary ammonium salt are reduced, so that the production cost is reduced.
Detailed Description
The raw materials used in the application can be obtained from the market
A preparation method of a long-acting lasting biguanide compound disinfectant comprises the following steps:
s1, dissolving the polyhexamethylene biguanide hydrochloride and the didecyldimethylammonium chloride in the formula amount into 50g of water, and uniformly stirring;
s2 adding povidone iodine, polyethylene glycol 200, tween, sodium dodecyl sulfate and dodecyl betaine in the formula amount into the solution obtained in S1, and stirring for 60min at normal temperature;
s3 adding water of the rest formula amount into the solution obtained in S2, adding 0.1g of phosphate buffer solution, and finally adjusting the pH to 4 by using citric acid to obtain a finished product.
Example 1
A long-acting durable biguanide composite disinfectant comprises 0.2g of polyhexamethylene biguanide hydrochloride, 3g of didecyldimethylammonium chloride, 1g of povidone iodine, 0.1g of tween 20, 0.1g of sodium dodecyl sulfate, 1g of dodecyl betaine and 95.6g of water.
Examples 2-5 differ from example 1 in the amounts of sodium lauryl sulfate and lauryl betaine used; examples 6 and 7 differ from example 4 in the amount of polyhexamethylene biguanide hydrochloride used; examples 8, 9 differ from example 4 in the amount of didecyldimethylammonium chloride used; examples 10, 11, 12 differ from example 4 in the amount of povidone-iodine used.
The raw material ratios of examples 1 to 12 are shown in Table 1.
TABLE 1 raw material ratios (unit: g) of examples 1 to 12
Comparative example
Comparative examples 1 to 4 are different from example 4 in the amount of sodium lauryl sulfate, lauryl betaine and water.
The amounts of the raw materials of comparative examples 1 to 4 are shown in Table 2
TABLE 2 raw material ratio of comparative examples 1 to 4 (unit: g)
Comparative example 5
A disinfectant comprises, based on 100g disinfectant, polyhexamethylene biguanide hydrochloride 0.2g, didecyldimethylammonium chloride 3g, povidone-iodine 1g, Tween 20 0.1g, polyethylene glycol 0.1g, potassium iodate 0.8g, potassium iodide 0.2g, and water 94.7g
Comparative examples 6 to 8 differ from example 4 in the amounts of polyhexamethylene biguanide hydrochloride, didecyldimethylammonium chloride, povidone-iodine, and water.
TABLE 3 raw material ratio of comparative examples 6 to 8 (unit: g)
Performance test
1. Sterilization performance detection
1.1 preparation of the bacterial suspension
The experimental strains are staphylococcus aureus (ATCC6538) and escherichia coli (ATCC11229) which are respectively prepared into 108cfu/ml bacterial suspension.
1.2 Experimental methods
Neutralization test method: 100ml of the suspension was divided into 50ml of the experimental group and 50ml of the control group.
5ml of the disinfectant obtained in examples 1 to 12 or comparative examples 5 to 8 was added to the test group, and the mixture was shaken in a shaker at 37 ℃ and 200rpm for 5min, and then taken out and added with a neutralizing agent in an amount equal to the amount of the long-acting biguanide complex disinfectant. After shaking up, 10 times of gradient dilution is carried out step by step, 0.1ml of suspension liquid of each dilution gradient is taken and smeared in a culture medium, and each concentration gradient is provided with two flat plates. The cells were incubated at 37 ℃ for 48 hours in an incubator.
Adding 5ml distilled water into blank group, placing in shaker at 37 deg.C and 200rpm, shaking, taking out after 5min, and adding neutralizer with equal volume to distilled water. After shaking up, 10 times of gradient dilution is carried out step by step, 0.1ml of suspension liquid of each dilution gradient is taken and smeared in a culture medium, and each concentration gradient is provided with two flat plates. The cells were incubated at 37 ℃ for 48 hours in an incubator.
The formula of the neutralizer is as follows: 05% sodium thiosulfate, 3% sodium sulfite, 2% lecithin, 5% tween-80, adding PBS solution to 100ml
1.3 data processing
And respectively counting the bacteria numbers of the experimental group and the blank group, converting the bacteria concentrations in the corresponding bacteria liquids, and calculating sterilization logarithm values.
The results of the experiments are shown in the following table:
TABLE 4 Sterilization Performance test of disinfectant
By combining examples 4, 6-12 and comparative examples 5-8, it can be seen that the combination of polyhexamethylene biguanide hydrochloride, didecyldimethylammonium chloride and povidone-iodine can improveThe disinfectant has the bactericidal effect, and especially when the dosage of the polyhexamethylene biguanide hydrochloride is 0.2 wt%, the dosage of the didecyldimethylammonium chloride is 3% and the dosage of the povidone iodine is 1%, the disinfectant can effectively kill the staphylococcus aureus and the escherichia coli, and 10% of the disinfectant can kill the staphylococcus aureus and the escherichia coli8When cfu/ml bacterial suspension is killed, the sterilization log value can reach 6.1 (staphylococcus aureus) and 5.9 (escherichia coli).
2. And (3) detecting the lasting bactericidal performance of the long-acting biguanide composite disinfectant.
2.1 preparation of the bacterial suspension
The experimental strain was Escherichia coli (ATCC11229) prepared as 108cfu/ml bacterial suspension.
2.2 Experimental methods
Preparing 10cm × 10cm sterile cotton cloth, uniformly spraying 10ml of the disinfectant obtained in examples 1-12 and comparative examples 1-8 on the surface of the cotton cloth, and acting for 5min to obtain an experimental group; another piece of sterile cotton cloth was prepared without any treatment and used as a control. It was placed in air and subjected to a permanent sterilization test. Relative light unit values (RLU) of the cotton surface were measured on day 1, day 2 and day 3 of the experiment using the System SURER Plus hand-held ATP fluorescence detection System manufactured by Hygiena, USA, respectively.
TABLE 5 results of the bactericidal durability test of the disinfectant
As can be seen by combining Table 5, examples 1-12 and comparative examples 1-8, the prepared disinfectant can form a film after being sprayed and dried when the sodium dodecyl sulfate and the dodecyl betaine are compounded, so that the long-acting sterilization effect is achieved.
Particularly, when the ratio of the sodium dodecyl sulfate to the betaine is 1:1, a film layer formed after the disinfectant is dried is more stable. The effective components in the disinfectant can be attached to the surface of the object to be applied for a longer time. The bactericide in example 4 can maintain effective bactericidal effect after being applied for 3 days.
3. And (3) detecting the adhesion performance of the long-acting biguanide composite disinfectant.
3.1 preparation of the bacterial suspension
The experimental strain was Escherichia coli (ATCC11229) prepared as 108cfu/ml bacterial suspension.
3.2 Experimental methods
S1, taking two 10cm × 10cm sterile cotton cloths, uniformly spraying 10ml of suspension liquid respectively, detecting the relative light unit value (RLU) on the surfaces of the cotton cloths by using a System SURER Plus handheld ATP fluorescence detection System produced by Hygiena of America, and recording the relative light unit value as the 0 th sampling;
then 5ml of disinfectant is evenly sprayed, and after 5min, a relative light unit value (RLU) of the surface of the cotton cloth is detected by using a handheld ATP fluorescence detection system and recorded as the 1 st sampling;
and S2, naturally drying the two aseptic cotton cloths, putting one aseptic cotton cloth into a shaking table, and oscillating in deionized water at the oscillation speed of 180 rpm. The mixture was shaken, taken out after 24 hours, and dried for future use. The other aseptic cotton cloth is placed in a natural state. And respectively and uniformly spraying 10ml of suspension liquid on the surfaces of the two pieces of cotton cloth. Relative light unit values (RLU) were measured after 5min on the cotton surface using a hand-held ATP fluorescence detection system and recorded as sample 2.
Step S2 is repeated twice, and the results of the two samplings are recorded as the 3 rd sampling and the 4 th sampling in sequence.
The results of the experiment are as follows:
TABLE 6 adhesion Performance test for Long-acting biguanide composite disinfectants
It can be seen from table 6 that the film formed by compounding sodium dodecyl sulfate and dodecyl betaine can effectively resist water erosion, thereby improving the water resistance of the disinfectant.
4. Sterilization effect test of long-acting biguanide compound disinfectant in different scenes
4.1 Experimental method, the disinfectant is sprayed on tables in office areas, wash tables in washrooms and air outlets of air conditioners. Uniformly spraying the mixture to the surface to be wet, and detecting the sprayed surface 5min, 24h, 48h and 72h after spraying.
The detection method comprises the following steps:
detecting relative light unit value (RLU) of the surface of the cotton cloth by using a System SURER Plus handheld ATP fluorescence detection System produced by Hygiena corporation of America;
TABLE 7.1 Table surface Disinfection longevity test
TABLE 7.2 Long-term detection of Disinfection of Wash basin surface
TABLE 7.3 air-conditioning outlet (wind speed: 8-10 m/s, temperature: 30 ℃) disinfection long-term effectiveness detection
It can be seen from tables 7.1, 7.2 and 7.3 that the disinfectant obtained by the application can maintain a long-time sterilization performance under different use scenes, and especially can maintain a good sterilization performance at desks (a disinfectant film is easily worn), washbasin places (a film is not easily attached) and air-conditioning air outlets (a film is easily cracked due to rapid water loss caused by airflow, and adhesiveness is affected).
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (10)
1. The long-acting lasting biguanide composite disinfectant is characterized by comprising, by weight, 0.1-0.3% of biguanide salt, 2-4% of quaternary ammonium salt, 0.8-1.4% of povidone iodine, 0.1-0.2% of tween, 0.08-0.12% of polyethylene glycol, 0.05-0.15% of sodium dodecyl sulfate and 0.05-0.15% of dodecyl betaine.
2. The long-acting durable biguanide compound disinfectant as claimed in claim 1, wherein: the weight ratio of the sodium dodecyl sulfate to the dodecyl betaine is 1: 1.
3. The long-acting durable biguanide compound disinfectant as claimed in claim 2, wherein: the weight percentage of the sodium dodecyl sulfate is 0.1 percent, and the weight percentage of the dodecyl betaine is 0.1 percent.
4. The long-acting durable biguanide compound disinfectant according to claim 1, 2 or 3, wherein: according to the weight percentage, the biguanide salt is 0.2%, the quaternary ammonium salt is 3%, and the povidone iodine is 1%.
5. The long-acting durable biguanide compound disinfectant as claimed in claim 1, wherein: the biguanide salt is selected from one or more of polyhexamethylene biguanide hydrochloride, polyaminopropyl biguanide hydrochloride, chlorhexidine acetate and chlorhexidine gluconate.
6. The long-acting durable biguanide compound disinfectant as claimed in claim 1, wherein: the quaternary ammonium salt is selected from one or more of didecyl dimethyl ammonium chloride, didodecyl dimethyl ammonium chloride, benzalkonium bromide and benzalkonium chloride.
7. The long-acting durable biguanide compound disinfectant as claimed in claim 1, wherein: the tween is one or more of tween 20, tween 60 and tween 80.
8. The long-acting durable biguanide compound disinfectant as claimed in claim 1, wherein: the polymerization degree of the polyethylene glycol is 200-2000.
9. A process for the preparation of a long acting biguanide complex disinfectant according to claims 1 to 8, wherein: the method comprises the following steps:
s1, dissolving the biguanide disinfectant and the quaternary ammonium salt disinfectant in water, and uniformly stirring;
s2 adding povidone iodine, tween, polyethylene glycol, sodium dodecyl sulfate and dodecyl betaine into the solution obtained in S1, and stirring at normal temperature for 50-80 min;
s3 adding water into the solution obtained in S2, adding a buffering agent, and adjusting the pH value to 3.7-4.2 to obtain a finished product.
10. A method for preparing the long-acting biguanide compound disinfectant as claimed in claim 9, wherein: the buffer is a phosphate buffer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111184554.8A CN113854290A (en) | 2021-10-11 | 2021-10-11 | Long-acting lasting biguanide compound disinfectant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111184554.8A CN113854290A (en) | 2021-10-11 | 2021-10-11 | Long-acting lasting biguanide compound disinfectant and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113854290A true CN113854290A (en) | 2021-12-31 |
Family
ID=78998491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111184554.8A Pending CN113854290A (en) | 2021-10-11 | 2021-10-11 | Long-acting lasting biguanide compound disinfectant and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113854290A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114631538A (en) * | 2022-04-22 | 2022-06-17 | 中国大熊猫保护研究中心 | Disinfectant for panda colony house, preparation method and disinfection method |
| CN115568475A (en) * | 2022-06-28 | 2023-01-06 | 黑龙江音速灵环保科技有限公司 | High-efficiency disinfectant and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256701A (en) * | 1990-11-19 | 1993-10-26 | Zenzo Tamura | Disinfectant composition |
| CN101579330A (en) * | 2009-06-25 | 2009-11-18 | 中国农业大学 | Disinfectant for animals and preparation method thereof |
| CN104644667A (en) * | 2015-02-12 | 2015-05-27 | 天津大学 | Compound disinfectant and preparation method thereof |
| CN109381480A (en) * | 2018-11-15 | 2019-02-26 | 南京聚锦医药科技有限公司 | Compound poly hexamethylene biguanide thimerosal and preparation method thereof |
| CN111296476A (en) * | 2020-04-07 | 2020-06-19 | 湖南坤源生物科技有限公司 | Long-acting disinfectant containing potassium hydrogen persulfate and preparation method thereof |
| CN113331218A (en) * | 2021-05-19 | 2021-09-03 | 安徽达尔美生物科技有限公司 | Household sterilizing disinfectant and preparation method thereof |
-
2021
- 2021-10-11 CN CN202111184554.8A patent/CN113854290A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256701A (en) * | 1990-11-19 | 1993-10-26 | Zenzo Tamura | Disinfectant composition |
| CN101579330A (en) * | 2009-06-25 | 2009-11-18 | 中国农业大学 | Disinfectant for animals and preparation method thereof |
| CN104644667A (en) * | 2015-02-12 | 2015-05-27 | 天津大学 | Compound disinfectant and preparation method thereof |
| CN109381480A (en) * | 2018-11-15 | 2019-02-26 | 南京聚锦医药科技有限公司 | Compound poly hexamethylene biguanide thimerosal and preparation method thereof |
| CN111296476A (en) * | 2020-04-07 | 2020-06-19 | 湖南坤源生物科技有限公司 | Long-acting disinfectant containing potassium hydrogen persulfate and preparation method thereof |
| CN113331218A (en) * | 2021-05-19 | 2021-09-03 | 安徽达尔美生物科技有限公司 | Household sterilizing disinfectant and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张志庆等: "十二烷基甜菜碱/十二烷基硫酸钠复配体系的表面活性", 《物理化学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114631538A (en) * | 2022-04-22 | 2022-06-17 | 中国大熊猫保护研究中心 | Disinfectant for panda colony house, preparation method and disinfection method |
| CN115568475A (en) * | 2022-06-28 | 2023-01-06 | 黑龙江音速灵环保科技有限公司 | High-efficiency disinfectant and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20070134136A1 (en) | Disinfecting composition | |
| US7163709B2 (en) | Composition for disinfection of plants, animals, humans, byproducts of plants and animals and articles infected with pathogens and method of producing and application of same | |
| US8933122B2 (en) | Use of cationic surfactants as sporicidal agents | |
| CN113854290A (en) | Long-acting lasting biguanide compound disinfectant and preparation method thereof | |
| CN101933521A (en) | Preparation and application thereof of sterilization composition | |
| CN112970752B (en) | Environment-friendly efficient surface disinfectant and preparation method thereof | |
| CN102090413A (en) | Preparation and application of compound disinfectant | |
| US5322856A (en) | Fortified glutaraldehyde chemical sterilant/disinfectant | |
| CN112022732A (en) | Hand-washing-free disinfectant and preparation method thereof | |
| KR100196460B1 (en) | Antimicrobial agent containing quaternary ammonium salt | |
| CN102318625A (en) | Preparation of leather composite bactericidal mould inhibitor | |
| JPH0418003A (en) | Bacterium-controlling agent for food-preparing environment | |
| FI83586C (en) | Use of an ester compound as a temporary microbicide | |
| CN102302033A (en) | Preparation and application of compounded disinfection atomization agent | |
| US8741954B2 (en) | Synergistic enhancement of calcium propionate | |
| JP7073593B1 (en) | Antibacterial, antifungal, antiviral disinfectant composition | |
| CN113940358B (en) | Efficient alcohol-free guanidine compound disinfectant and preparation method thereof | |
| CN102318634A (en) | Preparation method of compound leather bactericidal and mildew-proof agent | |
| CN102318635A (en) | Preparation method of compound leather bactericidal and mildew-proof agent | |
| CN106857659A (en) | A kind of thing table thimerosal of asepsis environment-protecting and preparation method thereof | |
| RU2226109C1 (en) | Disinfectant (variants) | |
| US9980490B1 (en) | Method of disinfecting bacterial contaminated surfaces or removing bacteria from contaminated surfaces | |
| US20230284627A1 (en) | Antimicrobial compositions and methods of use and for making same | |
| US10588313B1 (en) | Compounds of fatty acids and ammonium fatty acid salts | |
| CN114342950A (en) | Macromolecular guanidine salt disinfectant and preparation method and preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211231 |