CN102090413A - Preparation and application of compound disinfectant - Google Patents
Preparation and application of compound disinfectant Download PDFInfo
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- CN102090413A CN102090413A CN2010106006357A CN201010600635A CN102090413A CN 102090413 A CN102090413 A CN 102090413A CN 2010106006357 A CN2010106006357 A CN 2010106006357A CN 201010600635 A CN201010600635 A CN 201010600635A CN 102090413 A CN102090413 A CN 102090413A
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Abstract
The invention relates to a disinfectant, in particular to a preparation and application of a compound disinfectant containing various disinfection components, and the compound disinfectant comprises the following components by weight percent: 0.01%-5% of guanidine compound, 0.01%-10% of quaternary ammonium salt compound, 0.01%-2% of trilon B, 0.01%-2% of 2-bromo-2-nitro-1,3-propanediol, 0.01%-10% of monohydric alcohol, 0%-30% of dihydric alcohol, 0%-30% of polyhydric alcohol and the balance of water. The invention further provides the application of the compound disinfectant composition, the compound disinfectant composition can be applied in disinfection of object surfaces, air-conditioning systems, environments and air in the field of public health, the field of food processing and the filed of medical sanitation through a multifunctional atomizing machine for effectively preventing and killing vegetative forms of bacteria, mycobacteria, viruses, fungi and spores thereof, and the like, can be applied in the disinfection of the air in automobiles, the object surfaces and the air-conditioning systems through the multifunctional atomizing machine for effectively preventing and killing the vegetative forms of the bacteria, the mycobacteria, the viruses and the like, can be applied in the disinfection of the air in train carriages, cabins and the automobiles and the disinfection of objects and the environments through the multifunctional atomizing machine for effectively preventing and killing the vegetative forms of the bacteria, the mycobacteria, the viruses and the like, can be further applied in the disinfection of the environments, indoor spaces and the object surfaces in the field of livestock and poultry breeding through the multifunctional atomizing machine for effectively preventing and killing the vegetative forms of the bacteria, the mycobacteria, the viruses, the fungi and the spores thereof, and the like.
Description
Technical field
The invention belongs to the disinfection product scope, relate to a kind of preparation and application of composite disinfectant, especially a kind of compound with multiple effective disinfectant component is as the preparation and the application of disinfectant, wherein contain guanidine compound, quaternary ammonium compound, 2-bromo-2-nitro-1, the compound of ammediol, the upright imperial B of holder, monohydric alcohol, dihydroxylic alcohols and polyalcohol is as the preparation and the application of disinfectant.
Background technology
For a long time, extensively adopt chlorine-containing disinfectant, brominated disinfectant, guanidine class disinfectant and quaternary ammonium disinfectant in the sterile products field always.
The disinfection principle of chlorine-containing disinfectant is based on its hypochlorous sterilizing mechanisms by generating behind the hydrolysis in water.But in long-term use, find following shortcoming:
1, the pH value narrow range of its effective killing microorganisms, its minimum dissociation reaction occurs in the pH7.0 place, and when the pH value continued to raise, hypochlorous acid was dissociated into the hypochlorite ion of the power extreme difference of killing livestock easily in a large number.Because hypochlorite ion has negative electrical charge, when its when the microorganism, be subjected to the anion exclusion of load on the microorganism wall, be difficult to permeate through cell membranes, therefore just lost the vigor of killing microorganisms;
2, it can generate the carcinogenic substance chloroform with the organic matter in the water;
3, it has the smelly pungent taste of unpleasant chlorine, and skin is had excitant;
4, it is corrosive to metal, and fabric is had damage etc.
The disinfection principle of bromine-containing disinfectant is based on its sterilizing mechanisms by the hypobromous acid that generates behind the hydrolysis in water.But in use, find following shortcoming:
1, its solvability in water is little, and dissolution velocity is slow, has influenced it greatly as the application of disinfectant in the sterilization field;
2, its unpleasant bromine pungent taste has excitant to skin;
3, its metal is corrosive etc.
Guanidine class disinfectant and quaternary ammonium disinfectant all belong to low effect disinfectants, but only kill vegetative forms of bacteria and lipophilic virus, but can not kill mycobacterium, virus (removing lipophilic virus), fungi and spore thereof etc., can not kill bacteria gemma (pathogenic sporeformer), influenced it so greatly as the extensive use of disinfectant in the sterilization field.
Summary of the invention
The objective of the invention is to provides a kind of preparation and application thereof of composite disinfectant at the various drawbacks of existing disinfectant with for solving the technical problem that exists in the known technology, especially with preparation and the application as disinfectant of the compound of multiple effective disinfectant component, it has characteristics such as safety, efficient, wide spectrum, low toxicity, environmental protection.
One of purpose of the present invention provides a kind of composite disinfectant, especially a kind of preparation with the compound disinfectant of multiple effective disinfectant component, and composite disinfectant of the present invention contains following component by mass percent:
| Component | Mass percent % |
| Guanidine compound | 0.01~5 |
| Quaternary ammonium compound | 0.01~10 |
| Tuo Lilong B | 0.01~2 |
| 2-bromo-2-nitro-1, ammediol | 0.01~2 |
| Monohydric alcohol | 0.01~10 |
| Dihydroxylic alcohols | 0~30 |
| Polyalcohol | 0~30 |
| Water | Surplus |
Guanidine compound described in the component is selected from: polyhexamethylene guanide, poly hexamethylene biguanide, poly-one or more the mixture that encircles in guanidine, poly-[2-(2-ethyoxyl)-ethyoxyl second fat] guanidine etc.;
Wherein polyhexamethylene guanide is a kind of colourless, tasteless transparency liquid, and is soluble in water, and the aqueous solution is colourless, tasteless, do not fire not quick-friedly, metal material is not had corrosion substantially, decomposition temperature is greater than 400 ℃, to the handle no discoloration in surface, stable performance underwent no deterioration in 2 years.Very extensive in the every field application, can be used as the disinfectant of various body surfaces, and can make daily mould inhibitor; Can be widely used in the sterilization of beverage and food-processing industry, water body disinfection is cultured the industry sterilization, the construction material mildewproof additive, and plant sterilizes, and also can be used as the flocculant of waste water treatment.
Wherein poly hexamethylene biguanide is a kind of colourless, tasteless transparency liquid, have sterilization wide spectrum, stable in properties, soluble in water, can use at normal temperatures, have no side effect, non-corrosiveness, nontoxic, nonflammable, non-explosive, safe in utilization, in industrial, agriculture, medical and daily life, purposes is extremely widely arranged, its bactericidal mechanism is different with chlorine-containing disinfectant, strong oxidation reaction does not take place in the sterilization process, produce precipitation in the cell, the quantity of endocellular phosphorus rises simultaneously, thereby block cell wall and nucleic acid is synthetic; Reduce the cell permeability of the membrane, stop phosphorus to cell exocrine, and the energy bind protein, this disinfectant is widely used in pharmaceuticals industry, has when reporting it as mouthwash, and is very strong to the Gram-negative bacteria property killed.
Quaternary ammonium compound described in the component is selected from: the mixture of one or more in n-zephiran and two n-zephiran, the benzalkonium bromide etc.;
Wherein the n in the n-zephiran is 8-16, as dodecyl benzyl dimethyl ammonium chloride, hexadecyldimethyl benzyl ammonium benzyl oronain etc.Dodecyl benzyl dimethyl ammonium chloride is white waxy solid or yellow colloid, and the aqueous solution shows neutrality or faintly alkaline reaction, and soluble in water and ethanol has effect clean only, sterilization.When medical operating, be widely used in the sterilization of skin and operating theater instruments, also be widely used in the breed place of economic crops such as Treatment of Industrial Water, fowl corral house, granary, silkworm room and mushroom, tremella and sterilization, the sterilization, anticorrosion of utensil.Nontoxic to human body, little to skin and eyes mucosa irritation.
N in wherein two n-zephirans is 8-14.Two n-zephirans are two long chain quaternaries, and product type has multiple combining forms such as two octyl groups, two decyl, two dodecyl, octyl-decyl, and its bactericidal effect obviously strengthens.
Wherein benzalkonium bromide is white waxy solid or yellow colloid, the aqueous solution shows neutrality or faintly alkaline reaction, soluble in water, be slightly soluble in ethanol, be one of surfactant of using always, have cleaning, sterilizing and algae removal effect, be widely used in aspects such as sterilization, sterilization, anticorrosion, emulsification, de-sludging, solubilising, be industrial cycle water treatment non-oxidizable Biocidal algae-killing agent commonly used, glutinous mud remover and cleaning agent, also can be used for the control of microorganisms and the cleaning of circulation.
2-bromo-2-nitro-1 described in the component, ammediol, it is white or canescence crystalline powder, fusing point is greater than 120 ℃, soluble in water, have the high-efficiency broad spectrum antibacterial activity, be widely used as cosmetics preservative, also as agriculture chemicals fungicide, medical disinfectant, with the composite industrial water conditioning agent etc. that also can be used as of other preservatives;
The upright imperial B of holder described in the component is white crystalline powder, and is water-soluble, is insoluble in alcohol, as complexing agent, chelating agent, preservative, anti-oxidant synergist and auxiliary agent;
Monohydric alcohol described in the component is: 95% ethanol;
Dihydroxylic alcohols described in the component is selected from: the ethylene glycol APEO; 1, the 2-dihydroxypropane; The mixture of one or more in 2-ethyl-2-(methylol)-1,3 propane diols etc.;
Wherein the ethylene glycol APEO is an ethylene glycol APEO 200,400,600.It has passed through the U.S. FDA authentication, meets American Pharmacopeia (USP), NF (NF), and Food Chemistry code (FCC) standard is widely used in the production of industries such as food, pharmacy, feed, personal care articles, chemistry.It is the water white transparency thick liquid, and it is sweet to distinguish the flavor of, and has hygroscopicity, and is miscible with water, lower aliphatic alcohols, glycerine, acetic acid, acetone, can be used as solvent, dispersant, lubricant, emulsifier etc. and is used for cosmetics, agricultural chemicals, food, medicine and other fields.
Wherein 1, the 2-dihydroxypropane is the stable water imbibition liquid of colourless thickness, almost tasteless odorless, with water, ethanol and multiple immiscible organic solvent, as gas-chromatography fixer, solvent, antifreeze, plasticizer, dehydrating agent, carrier solvent, wetting agent, humectant, anticaking agent, antioxidant, surface-active, stabilizing agent, thickener, emulsifier, processing aid, it classifies food processing aid as among the GB 2760-96, its aqueous solution is effective antifreeze, can be used as humectant in the cosmetics, softening agent, solvent etc.
Trihydroxylic alcohol described in the component is selected from: the mixture of one or more in trihydroxy propane, triethylene-glycol, the tetraethylene-glycol etc.;
Wherein trihydroxy propane outward appearance is the water white transparency thick liquid, odorless, tasteless, have hygroscopicity, humectation, a property of softening, it is neutral that the aqueous solution is, can mix arbitrarily with water, ethanol, methyl alcohol, have good freeze-proof, be widely used in industries such as weaving, printing and dyeing, papermaking, printing, washing agent, daily use chemicals, system wine, food, cigarette, glassine paper, enamel, oil, electronics, rubber, plastics, process hides, chemistry, chemical fibre.Main as humectant, humectant, hygroscopic agent, lubricant, softening agent, softening agent, thickener, plasticizer, thinner, antifreezing agent etc.
Wherein the triethylene-glycol outward appearance is that no color or smell has the hygroscopicity thick liquid, can be miscible with water, ethanol, benzene, toluene, be insoluble in ethers, and be insoluble to benzinum, have hygroscopicity, have the character of pure and mild ether.As solvent, extractant, desiccant, air disinfection agent etc.The toxicity data are little poison, LD
50(rat oral) 16.8ml/kg. is to eyes and skin nonirritant.
Water described in the component is: deionized water.
Each component is role in the present invention:
Guanidine compound described in the component belongs to cationic surfactant, is low effect disinfectants, has quick-acting bactericidal actions, to mucocutaneous nonirritant, to metal and fabric non-corrosiveness, is subjected to organic substance influence slight, good stability;
Quaternary ammonium compound described in the component belongs to cationic surfactant, is low effect disinfectants, and to mucocutaneous non-stimulated, toxicity is little, and good stability is harmless to article;
2-bromo-2-nitro-1 described in the component, ammediol is a disinfectant, broad spectrum antibiotic activity can effectively suppress Gram-negative bacteria, positive bacteria, saccharomycete and mould;
The upright imperial B of holder described in the component has chelating, complexing and synergistic effect, can remove the Ca that exists in the water
2+, Mg
2+, Fe
2+, Mn
2+Deng metal ion, reach purification;
Monohydric alcohol described in the component has synergistic effect, has hydrotropy and antifreeze effect simultaneously;
Dihydroxylic alcohols described in the component plays good dispersion and antifreeze effect, to mucocutaneous non-stimulated, good stability is harmless to article;
Polyalcohol described in the component plays good atomizing and synergistic effect, to mucocutaneous nonirritant, to metal and fabric non-corrosiveness, good stability;
Composite disinfectant agent of the present invention is the proportioning of following mass percent most preferably:
| Component | Mass percent % |
| Guanidine compound | 0.01~2 |
| Quaternary ammonium compound | 0.01~1 |
| Tuo Lilong B | 0.01~2 |
| 2-bromo-2-nitro-1, ammediol | 0.01~1 |
| Monohydric alcohol | 0.01~5 |
| Dihydroxylic alcohols | 0~20 |
| Polyalcohol | 5~30 |
| Water | Surplus |
Guanidine compound described in the component is selected from: polyhexamethylene guanide, poly hexamethylene biguanide, poly-one or more the mixture that encircles in guanidine, poly-[2-(2-ethyoxyl)-ethyoxyl second fat] guanidine etc.;
Quaternary ammonium compound described in the component is selected from: the mixture of one or more in n-zephiran and two n-zephiran, the benzalkonium bromide etc., wherein the n in the n-zephiran is 8-16, and the n in two n-zephirans is 8-14;
Monohydric alcohol described in the component is: 95% ethanol;
Dihydroxylic alcohols described in the component is selected from: the ethylene glycol APEO; 1, the 2-dihydroxypropane; The mixture of one or more in 2-ethyl-2-(methylol)-1,3 propane diols etc., wherein the ethylene glycol APEO is an ethylene glycol APEO 200,400,600;
Polyalcohol is selected from the component described in the component: the mixture of one or more of trihydroxy propane, triethylene-glycol, tetraethylene-glycol etc.;
Water described in the component is: deionized water.
Another object of the present invention is, a kind of compound method of composite disinfectant is provided, it mainly is to adopt guanidine compound, quaternary ammonium compound, 2-bromo-2-nitro-1, and ammediol, the upright imperial B of holder, monohydric alcohol, dihydroxylic alcohols, polynary alcohol and water are prepared from through mixing, react, stir, leaving standstill:
The compound method of the above-mentioned composite disinfectant that contains the mass percent component is as follows:
1, with guanidine compound, quaternary ammonium compound, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B are by above-mentioned quality
50% water of percentage and above-mentioned mass percent mixes to stir and was mixed with compounding substances A in 3 hours;
2, monohydric alcohol, dihydroxylic alcohols and polyalcohol are mixed stirring by above-mentioned mass percent with the water of above-mentioned mass percent remaining 50% and be mixed with compounding substances B in 3 hours;
3, with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed
Mixture carries out assay, and qualified mixture is packed, and is qualified products.
Purpose of the present invention also comprises the application that above-mentioned composite disinfectant is provided:
1, by multi-functional atomizer be applied to public health field, food processing field and medicine and hygiene fields body surface,
The sterilization of air-conditioning system, environment and air can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus, fungi and spore thereof etc.;
2, be applied to the sterilization of air, body surface and the air-conditioning system of automotive interior by multi-functional atomizer, can be effectively
Prevention and kill vegetative forms of bacteria, mycobacterium, virus etc.;
3, be applied to check the internal container of checking system by multi-functional atomizer, railway carriage, cabin, automotive interior
The sterilization of air sterillization, sterilisation of objects and environment, can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus etc.;
4, be applied to the environment in livestock and poultry cultivation field, the sterilization of indoor and body surface by multi-functional atomizer, can be effective
Ground prevention and kill vegetative forms of bacteria, mycobacterium, virus, fungi and spore thereof etc.
Combination matching between each component of composite disinfectant of the present invention has the effect of Synergistic, and has following advantage and good effect:
1, harmless to people, animal, can not produce harmful substance, do not pollute the environment safety and environmental protection;
2, non-stimulated to skin and mucosa;
3, article and fabric there is not corrosivity;
4, have no irritating odor, colourless;
5, be not subjected to the influence of environment, organic matter, acid, alkali and other physics, chemical factor.
Embodiment
Embodiment 1
| Component | Kilogram kg | Mass percent % |
| Polyhexamethylene guanide | 0.3 kg | 0.3 % |
| Benzalkonium bromide | 0.7 kg | 0.7 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| 1, the 2-dihydroxypropane | 20 kg | 20 % |
| Trihydroxy propane | 10 kg | 10 % |
| Water | 68.37 kg | 68.37 % |
| Amount to | 100 kg | 100 % |
1) with polyhexamethylene guanide, benzalkonium bromide, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B are by above-mentioned mass percent and last
50% the water of stating mass percent mixes to stir and was mixed with compounding substances A in 3 hours;
2) with 95% ethanol, 1,2-dihydroxypropane and trihydroxy propane are remaining by above-mentioned mass percent and above-mentioned mass percent
50% water mixes stirring and was mixed with compounding substances B in 3 hours;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 2
| Component | Kilogram kg | Mass percent % |
| Poly hexamethylene biguanide | 0.3 kg | 0.3 % |
| Dodecyl benzyl dimethyl ammonium chloride | 0.7 kg | 0.7 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| 2-ethyl-2-(methylol)-1,3 propane diols | 20 kg | 20 % |
| Triethylene-glycol | 10 kg | 10 % |
| Water | 68.37 kg | 68.37 % |
| Amount to | 100 kg | 100 % |
1) with poly hexamethylene biguanide, dodecyl benzyl dimethyl ammonium chloride, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mixes stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and was mixed with compounding substances A in 3 hours;
2) 95% ethanol, 2-ethyl-2-(methylol)-1,3 propane diols and triethylene-glycol are pressed above-mentioned mass percent and above-mentioned
The water of mass percent remaining 50% mixes stirring and was mixed with compounding substances B in 3 hours;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 3
| Component | Kilogram kg | Mass percent % |
| Poly-[the 2-(2-ethyoxyl)-ethyoxyl second fat] guanidine | 0.2 kg | 0.2 % |
| Two ten zephirans | 0.8 kg | 0.8 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| 2-ethyl-2-(methylol)-1,3 propane diols | 10 kg | 10 % |
| Triethylene-glycol | 10 kg | 10 % |
| Water | 78.37 kg | 78.37 % |
| Amount to | 100 kg | 100 % |
1) will gather [2-(2-ethyoxyl)-ethyoxyl second fat] guanidine, two ten zephirans, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mix stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and were mixed with compounding substances A in 3 hours;
2) 95% ethanol, 2-ethyl-2-(methylol)-1,3 propane diols and triethylene-glycol are pressed above-mentioned mass percent and above-mentioned
The water of mass percent remaining 50% mixes stirring and was mixed with compounding substances B in 3 hours;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 4
| Component | Kilogram kg | Mass percent % |
| Poly-[the 2-(2-ethyoxyl)-ethyoxyl second fat] guanidine | 0.2 kg | 0.2 % |
| Two ten alkyl-dimethyl ammonium chlorides | 0.8 kg | 0.8 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| 1, the 2-dihydroxypropane | 10 kg | 10 % |
| Trihydroxy propane | 10 kg | 10 % |
| Water | 78.37 kg | 78.37 % |
| Amount to | 100 kg | 100 % |
1) will gather [2-(2-ethyoxyl)-ethyoxyl second fat] guanidine, two ten alkyl-dimethyl ammonium chlorides, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mix stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and were mixed with compounding substances A in 3 hours;
2) with 95% ethanol, 1,2-dihydroxypropane and trihydroxy propane are remaining by above-mentioned mass percent and above-mentioned mass percent
50% water mixes stirring and was mixed with compounding substances B in 3 hours;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 5
| Component | Kilogram kg | Mass percent % |
| Poly hexamethylene biguanide | 0.4 kg | 0.4 % |
| Cetalkonium chloride | 0.6 kg | 0.6 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| 1, the 2-dihydroxypropane | 10 kg | 10 % |
| Trihydroxy propane | 10 kg | 10 % |
| Water | 78.37 kg | 78.37 % |
| Amount to | 100 kg | 100 % |
1) with poly hexamethylene biguanide, cetalkonium chloride, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mixes stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and was mixed with compounding substances A in 3 hours;
2) with 95% ethanol, 1,2-dihydroxypropane and trihydroxy propane are remaining by above-mentioned mass percent and above-mentioned mass percent
50% water mixes stirring and was mixed with compounding substances B in 3 hours;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 6
| Component | Kilogram kg | Mass percent % |
| Poly hexamethylene biguanide | 0.4 kg | 0.4 % |
| Cetalkonium chloride | 0.6 kg | 0.6 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| Ethylene glycol APEO 200 | 20 kg | 20 % |
| Tetraethylene-glycol | 10 kg | 10 % |
| Water | 68.37 kg | 68.37 % |
| Amount to | 100 kg | 100 % |
1) with poly hexamethylene biguanide, cetalkonium chloride, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mixes stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and was mixed with compounding substances A in 3 hours;
2) 95% ethanol, ethylene glycol APEO 200 and tetraethylene-glycol are mixed stirring by above-mentioned mass percent with the water of above-mentioned mass percent remaining 50% and be mixed with compounding substances B in 3 hours;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 7
| Component | Kilogram kg | Mass percent % |
| Poly hexamethylene biguanide | 0.4 kg | 0.4 % |
| Two octyldimethyl benzyl ammonium chlorides | 0.6 kg | 0.6 % |
| Tuo Lilong B | 0.03 kg | 0.03 % |
| 2-bromo-2-nitro-1, ammediol | 0.1 kg | 0.1 % |
| 95% ethanol | 0.5 kg | 0.5 % |
| 1, the 2-dihydroxypropane | 30 kg | 30 % |
| Trihydroxy propane | 10 kg | 10 % |
| Water | 58.37 kg | 58.37 % |
| Amount to | 100 kg | 100 % |
1) with poly hexamethylene biguanide, two octyldimethyl benzyl ammonium chloride, 2-bromo-2-nitro-1, ammediol and Tuo Li dragon B mixes stirring by 50% water of above-mentioned mass percent and above-mentioned mass percent and was mixed with compounding substances A in 3 hours;
2) with 95% ethanol, 1,2-dihydroxypropane and trihydroxy propane mix stirring by above-mentioned mass percent and were mixed with compounding substances B in 3 hours with the water of above-mentioned mass percent remaining 50%;
3) with said mixture matter A and said mixture matter B stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
The experimental study that composite disinfectant product of the present invention is carried out:
1, to the killing effect of staphylococcus aureus (ATCC 6538)
2, to the killing effect of Escherichia coli (8099)
3, to the killing effect of influenza virus, HIV virus:
4, the air of doing in certain hospital and the field trial of body surface
The present invention is further elaborated by above embodiment, but does not limit the scope of the invention.
Claims (7)
1. composite disinfectant is characterized in that this composite disinfectant comprises following component by mass percent:
Guanidine compound is selected from the wherein said component: polyhexamethylene guanide, poly hexamethylene biguanide, poly-one or more the mixture that encircles in guanidine, poly-[2-(2-ethyoxyl)-ethyoxyl second fat] guanidine etc.
2. composite disinfectant as claimed in claim 1, it is characterized in that described quaternary ammonium compound is selected from: the mixture of one or more in n-zephiran and two n-zephiran, the benzalkonium bromide etc., wherein the n in the n-zephiran is 8-16; N in wherein two n-zephirans is 8-14.
3. composite disinfectant as claimed in claim 1 is characterized in that described monohydric alcohol is: 95% ethanol.
4. composite disinfectant as claimed in claim 1, it is characterized in that described dihydroxylic alcohols is: 1,2-dihydroxypropane, 2-ethyl-2-(methylol)-1, the mixture of one or more of 3 propane diols, ethylene glycol APEO etc., wherein the ethylene glycol APEO is an ethylene glycol APEO 200,400,600.
5. composite disinfectant as claimed in claim 1 is characterized in that described polyalcohol is: the mixture of one or more of trihydroxy propane, triethylene-glycol, tetraethylene-glycol etc.
6. composite disinfectant as claimed in claim 1 is characterized in that described water is: deionized water.
7. application as the described arbitrary composite disinfectant of claim 1-6, it is characterized in that: be applied to the sterilization of body surface, air-conditioning system, environment and the air of public health field, food processing field and medicine and hygiene fields by multi-functional atomizer, can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus, fungi and spore thereof etc.; Be applied to the sterilization of air, body surface and the air-conditioning system of automotive interior by multi-functional atomizer, can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus etc.; Be applied to check the internal container of checking system by multi-functional atomizer, the sterilization of the air sterillization of railway carriage, cabin, automotive interior, sterilisation of objects and environment can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus etc.; Be applied to the environment in livestock and poultry cultivation field, the sterilization of indoor and body surface by multi-functional atomizer, can effectively prevent and kill vegetative forms of bacteria, mycobacterium, virus, fungi and spore thereof etc.
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| CN2010106006357A CN102090413A (en) | 2010-12-22 | 2010-12-22 | Preparation and application of compound disinfectant |
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| CN2010106006357A CN102090413A (en) | 2010-12-22 | 2010-12-22 | Preparation and application of compound disinfectant |
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| CN102090413A true CN102090413A (en) | 2011-06-15 |
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| CN2010106006357A Withdrawn CN102090413A (en) | 2010-12-22 | 2010-12-22 | Preparation and application of compound disinfectant |
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| CN105284860A (en) * | 2014-06-16 | 2016-02-03 | 盐城市聚科化工有限公司 | Multiple-effect antibacterial agent composition for wet tissue and production method thereof |
| CN105532739A (en) * | 2016-01-03 | 2016-05-04 | 安徽律正科技信息服务有限公司 | Antimicrobial composition with excellent biocompatibility |
| CN105875623A (en) * | 2016-06-15 | 2016-08-24 | 王兰英 | Disinfectant for glassware for test |
| CN106172419A (en) * | 2016-07-27 | 2016-12-07 | 南通华露针织品有限公司 | Sanitary disinfecting disinfectant |
| CN106259442A (en) * | 2016-07-19 | 2017-01-04 | 成都科宏达科技有限公司 | A kind of compound disinfectant containing iodine |
| CN106857659A (en) * | 2017-04-01 | 2017-06-20 | 江西凝盛生物科技有限公司 | A kind of thing table thimerosal of asepsis environment-protecting and preparation method thereof |
| CN108472505A (en) * | 2015-12-22 | 2018-08-31 | 3M创新有限公司 | The method removed for spore |
| CN108697077A (en) * | 2015-09-25 | 2018-10-23 | 组合块公司 | Polyalcohol, carbohydrate, nucleobase and nucleotide composition and application thereof |
| CN108849891A (en) * | 2018-09-10 | 2018-11-23 | 美国太平洋大桥股份有限公司 | A kind of air sterilizing disinfectant |
| CN114027299A (en) * | 2021-12-09 | 2022-02-11 | 江苏瑞安汽车实业有限公司 | Atomizing and refreshing bactericide for internal circulation space of air conditioner and preparation method of bactericide |
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- 2010-12-22 CN CN2010106006357A patent/CN102090413A/en not_active Withdrawn
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105284860A (en) * | 2014-06-16 | 2016-02-03 | 盐城市聚科化工有限公司 | Multiple-effect antibacterial agent composition for wet tissue and production method thereof |
| CN108697077B (en) * | 2015-09-25 | 2022-04-19 | 组合块公司 | Polyol, carbohydrate, nucleobase and nucleoside compositions and uses thereof |
| US11553713B2 (en) | 2015-09-25 | 2023-01-17 | Chunbo Zhang | Polyalcohol, carbohydrate, nucleobase and nucleotide compositions and uses thereof |
| CN108697077A (en) * | 2015-09-25 | 2018-10-23 | 组合块公司 | Polyalcohol, carbohydrate, nucleobase and nucleotide composition and application thereof |
| CN108472505A (en) * | 2015-12-22 | 2018-08-31 | 3M创新有限公司 | The method removed for spore |
| CN105532739A (en) * | 2016-01-03 | 2016-05-04 | 安徽律正科技信息服务有限公司 | Antimicrobial composition with excellent biocompatibility |
| CN105875623A (en) * | 2016-06-15 | 2016-08-24 | 王兰英 | Disinfectant for glassware for test |
| CN106259442A (en) * | 2016-07-19 | 2017-01-04 | 成都科宏达科技有限公司 | A kind of compound disinfectant containing iodine |
| CN106172419A (en) * | 2016-07-27 | 2016-12-07 | 南通华露针织品有限公司 | Sanitary disinfecting disinfectant |
| CN106857659A (en) * | 2017-04-01 | 2017-06-20 | 江西凝盛生物科技有限公司 | A kind of thing table thimerosal of asepsis environment-protecting and preparation method thereof |
| CN108849891B (en) * | 2018-09-10 | 2021-08-10 | 美国太平洋大桥股份有限公司 | Air sterilization disinfectant |
| CN108849891A (en) * | 2018-09-10 | 2018-11-23 | 美国太平洋大桥股份有限公司 | A kind of air sterilizing disinfectant |
| CN114027299A (en) * | 2021-12-09 | 2022-02-11 | 江苏瑞安汽车实业有限公司 | Atomizing and refreshing bactericide for internal circulation space of air conditioner and preparation method of bactericide |
| CN114027299B (en) * | 2021-12-09 | 2023-02-28 | 江苏瑞安汽车实业有限公司 | Atomizing and refreshing bactericide for internal circulation space of air conditioner and preparation method of bactericide |
| WO2023159278A1 (en) * | 2022-02-28 | 2023-08-31 | Squire Kent Pty Limited | Anti-pathogenic aerosol compositions |
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Open date: 20110615 |