CN115568475A - High-efficiency disinfectant and preparation method thereof - Google Patents
High-efficiency disinfectant and preparation method thereof Download PDFInfo
- Publication number
- CN115568475A CN115568475A CN202210752620.5A CN202210752620A CN115568475A CN 115568475 A CN115568475 A CN 115568475A CN 202210752620 A CN202210752620 A CN 202210752620A CN 115568475 A CN115568475 A CN 115568475A
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- CN
- China
- Prior art keywords
- disinfectant
- quaternary ammonium
- ammonium salt
- biguanide
- chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to the field of A61K8/41, in particular to a high-efficiency disinfectant and a preparation method thereof. The invention takes biguanide compounds, quaternary ammonium salt compounds and water as raw materials, and adopts specific biguanide compounds and quaternary ammonium salt compounds to cooperate and compound, thereby effectively improving the sterilization effect of the disinfectant, enabling the disinfectant to rapidly kill coronavirus, and being widely applied to daily environment and human body sterilization.
Description
Technical Field
The invention relates to the field of A61K8/41, in particular to a high-efficiency disinfectant and a preparation method thereof.
Background
In recent years, disinfection becomes necessary work in daily life, but the bacteriostatic and disinfecting effect of the traditional medical alcohol disinfection is extremely limited and is not enough to meet the disinfection of new coronavirus, so that the disinfection solution which is safe and efficient and can quickly kill coronavirus is urgently provided for the current stage of requirements.
Chinese patent CN113575610A discloses a low temperature resistant hydrogen peroxide disinfectant and a preparation method thereof, wherein a hydrogen peroxide solution, an antifreezing agent, a pH regulator, a stabilizer and water are used as raw materials, although the disinfection effect at low temperature is verified to be effective, the disinfectant is only directed to some microorganisms such as bacterial propagules, spores and fungi, and cannot effectively kill coronavirus. Chinese patent CN112716822A discloses an anti-new coronavirus disinfectant and a preparation method thereof, wherein didecyl dimethyl ammonium chloride and silver ions are used as disinfection components, and a thickener, a surfactant and other auxiliaries are cooperated to ensure that the provided disinfectant has a certain inhibition effect on the new coronavirus, but the silver ions have high cost, so that the disinfectant is not beneficial to large-scale industrial production and application, and the application of the disinfectant is limited.
Therefore, the disinfectant provided by the invention adopts the synergistic compounding of the specific biguanide and the quaternary ammonium salt compound, effectively improves the sterilization and disinfection effects of the disinfectant, can quickly kill coronavirus, and can be widely applied to daily environment and human body sterilization and disinfection.
Disclosure of Invention
In order to solve the above problems, one aspect of the present invention provides a high efficiency disinfectant, which is prepared from at least the following components: biguanide compounds, quaternary ammonium salt compounds and water.
As a preferred technical scheme, the preparation raw materials of the disinfection solution comprise, by mass: 0.1-0.3% of biguanide compounds, 0.1-0.6% of quaternary ammonium salt compounds and the balance of water.
As a preferable technical scheme, the biguanide compound is one or a combination of several selected from moroxydine hydrochloride, polyhexamethylene biguanide hydrochloride, biguanide trioctyl benzene sulfonate and hexamethylene bis-octaguanidine dihydrochloride; preferably, the biguanide compound is polyhexamethylene biguanide hydrochloride; the polyhexamethylene biguanide hydrochloride is from Wuhananabai pharmaceutical chemical Co.
As a preferred technical solution, the quaternary ammonium salt compound includes a double-chain quaternary ammonium salt compound; the double-chain quaternary ammonium salt compound is didecyl dimethyl ammonium chloride and/or didecyl dimethyl ammonium bromide.
As a preferable technical scheme, the quaternary ammonium salt compound also comprises one or a combination of more of dodecyl dimethyl benzyl ammonium chloride, hexadecyl dimethyl benzyl ammonium chloride, dodecyl dimethyl phenoxy ethyl ammonium bromide and benzalkonium chloride;
preferably, the quaternary ammonium salt compound is a combination of didecyl dimethyl ammonium chloride and benzalkonium chloride; preferably, the mass ratio of the combination of the didecyl dimethyl ammonium chloride and the benzalkonium chloride is (0.8-1.2): 1.
Based on the system, the combination of the didecyl dimethyl ammonium chloride and the benzalkonium chloride has obvious synergistic effect, and especially when the mass ratio of the combination of the didecyl dimethyl ammonium chloride and the benzalkonium chloride in the system is (0.8-1.2): 1, the polyhexamethylene biguanide hydrochloride in the synergistic system ensures that the provided disinfectant can rapidly kill coronavirus, and the sterilization rate is as high as 99.99%. In addition, the combination of the didecyl dimethyl ammonium chloride and the benzalkonium chloride with the mass ratio of (0.8-1.2): 1 is introduced, so that the surface activity of the system is obviously improved, the provided disinfectant is not easily interfered by factors such as organic matters, pH, water quality, temperature and the like, and the application of the disinfectant to the disinfection of the medical and public place environments and the surfaces of various objects is expanded. And the disinfectant has stable product property, is non-volatile and non-degradable, has no pungent smell, has no residual toxicity and is safe to use.
The invention also provides a preparation method of the high-efficiency disinfectant, which is obtained by dissolving the biguanide compounds and the quaternary ammonium salt compounds into water.
Has the advantages that:
1. the specific biguanide and quaternary ammonium salt compound are compounded in a synergistic manner, so that the sterilization and disinfection effects of the disinfectant are effectively improved, the provided disinfectant can rapidly kill coronavirus, and the disinfectant can be widely applied to disinfection in daily environment and human body.
2. Based on the system, the combination of the didecyl dimethyl ammonium chloride and the benzalkonium chloride has obvious synergistic effect, and especially when the mass ratio of the combination of the didecyl dimethyl ammonium chloride and the benzalkonium chloride in the system is (0.8-1.2): 1, the polyhexamethylene biguanide hydrochloride in the synergistic system ensures that the provided disinfectant can rapidly kill coronavirus, and the sterilization rate is as high as 99.99%.
3. The high-efficiency disinfectant provided by the invention introduces the combination of didecyl dimethyl ammonium chloride and benzalkonium chloride with the mass ratio of (0.8-1.2): 1, so that the surface activity of the system is obviously improved, the provided disinfectant is not easily interfered by factors such as organic matters, pH, water quality, temperature and the like, and the application of the disinfectant to the disinfection of medical and public place environments and the surfaces of various objects is expanded.
4. The high-efficiency disinfectant provided by the invention has stable product property, is non-volatile, is not decomposed, has no pungent smell, has no residual toxicity and is safe to use.
Drawings
Figure 1 is a report of the identification test and virus inactivation test for the physical removal of residual disinfectant of example 1.
Detailed Description
Example 1
The embodiment 1 of the invention provides a high-efficiency disinfectant, and the preparation raw materials comprise the following components in percentage by mass: 0.2 percent of biguanide compounds, 0.4 percent of quaternary ammonium salt compounds and the balance of water.
The biguanide compound is polyhexamethylene biguanide hydrochloride; the polyhexamethylene biguanide hydrochloride is from Wuhananabai pharmaceutical chemical Co.
The quaternary ammonium salt compound is the combination of didecyl dimethyl ammonium chloride and benzalkonium chloride; the mass ratio of the combination of the didecyl dimethyl ammonium chloride and the benzalkonium chloride is 1.
In another aspect, embodiment 1 of the present invention provides a method for preparing a high efficiency disinfectant, in which a biguanide compound and a quaternary ammonium salt compound are dissolved in water.
Comparative example 1
Comparative example 1 of the present invention provides a highly effective disinfectant, which is similar to example 1 in specific embodiment, except that the quaternary ammonium salt compound is polyhexamethylene biguanide hydrochloride.
Performance test method
1. The high-efficiency disinfectant prepared in example 1 is subjected to an identification test of a physical residual disinfectant removing method and a virus inactivation test, and a specific detection report is shown in fig. 1.
2. Stability: the high-efficiency disinfectant prepared in example 1 and comparative example 1 was sealed in a polyethylene plastic bottle, and the inactivation rate of the high-efficiency disinfectant on coronavirus was measured after 12 months of storage at 30 ± 2 ℃ and a relative humidity of 65 ± 5%, and the performance test results are shown in table 1.
TABLE 1,
Claims (10)
1. The high-efficiency disinfectant is characterized in that the preparation raw materials at least comprise the following components: biguanide compounds, quaternary ammonium salt compounds and water.
2. The high-efficiency disinfection solution as claimed in claim 1, wherein the raw materials for preparing the disinfection solution comprise, by mass: 0.1-0.3% of biguanide compounds, 0.1-0.6% of quaternary ammonium salt compounds and the balance of water.
3. The disinfectant as claimed in claim 1 or 2, wherein the biguanide compound is selected from moroxydine hydrochloride, polyhexamethylene biguanide hydrochloride, iminoctadecyl benzene sulfonate, and hexadioctylguanidine dihydrochloride.
4. The disinfectant fluid as claimed in claim 3, wherein said biguanide compound is polyhexamethylene biguanide hydrochloride.
5. A high-efficiency disinfectant liquid as claimed in claim 3, wherein said quaternary ammonium salt compound comprises a double-chain quaternary ammonium salt compound.
6. A highly effective disinfectant liquid according to claim 5, wherein said double-chain quaternary ammonium salt compound is didecyldimethylammonium chloride and/or didecyldimethylammonium bromide.
7. The disinfectant liquid as claimed in claim 5, wherein said quaternary ammonium salt compound further comprises one or more of dodecyl dimethyl benzyl ammonium chloride, hexadecyl dimethyl benzyl ammonium chloride, dodecyl dimethyl phenoxy ethyl ammonium bromide, and benzalkonium chloride.
8. The disinfectant liquid as set forth in claim 7, wherein said quaternary ammonium salt compound is a combination of didecyldimethyl ammonium chloride and benzalkonium chloride.
9. The high efficiency disinfectant as set forth in claim 8, wherein the mass ratio of said didecyl dimethyl ammonium chloride to benzalkonium chloride is (0.8-1.2): 1.
10. The method for preparing the high-efficiency disinfectant according to any one of claims 1 to 9, wherein the disinfectant is prepared by dissolving a biguanide compound and a quaternary ammonium salt compound in water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210752620.5A CN115568475A (en) | 2022-06-28 | 2022-06-28 | High-efficiency disinfectant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210752620.5A CN115568475A (en) | 2022-06-28 | 2022-06-28 | High-efficiency disinfectant and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115568475A true CN115568475A (en) | 2023-01-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210752620.5A Pending CN115568475A (en) | 2022-06-28 | 2022-06-28 | High-efficiency disinfectant and preparation method thereof |
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| Country | Link |
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| CN (1) | CN115568475A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933521A (en) * | 2009-07-01 | 2011-01-05 | 李新建 | Preparation and application thereof of sterilization composition |
| CN111248220A (en) * | 2020-03-11 | 2020-06-09 | 上海沛爱生物技术有限公司 | Composite efficient sterilization disinfectant |
| CN113854290A (en) * | 2021-10-11 | 2021-12-31 | 中科朗劢技术有限公司 | Long-acting lasting biguanide compound disinfectant and preparation method thereof |
-
2022
- 2022-06-28 CN CN202210752620.5A patent/CN115568475A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933521A (en) * | 2009-07-01 | 2011-01-05 | 李新建 | Preparation and application thereof of sterilization composition |
| CN111248220A (en) * | 2020-03-11 | 2020-06-09 | 上海沛爱生物技术有限公司 | Composite efficient sterilization disinfectant |
| CN113854290A (en) * | 2021-10-11 | 2021-12-31 | 中科朗劢技术有限公司 | Long-acting lasting biguanide compound disinfectant and preparation method thereof |
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