JP3607555B2

JP3607555B2 - Disinfectant composition

Info

Publication number: JP3607555B2
Application number: JP2000041092A
Authority: JP
Inventors: 清章吉川; 由博山崎; 哲也岡野; 成田村
Original assignee: Kao Corp
Current assignee: Kao Corp
Priority date: 1999-12-10
Filing date: 2000-02-18
Publication date: 2005-01-05
Anticipated expiration: 2020-02-18
Also published as: JP2001226208A

Description

【０００１】
【発明の属する技術分野】
本発明は殺菌剤組成物に関する。
【０００２】
【従来の技術及び発明が解決しようとする課題】
従来、広範な環境における殺菌消毒剤として、次亜塩素酸ナトリウム、次亜塩素酸カルシウム、ジクロロイソシアヌル酸ナトリウム等の塩素系殺菌剤が広く用いられている。中でも次亜塩素酸ナトリウム等の次亜塩素酸塩は、価格面と効果の点で汎用されているが、医療、食品工業等、種々の分野で要求される微生物の殺菌、滅菌に対して、更にその効力を向上させるための多くの提案がなされている。例えば、特開昭５７−６１０９９号には、次亜塩素酸塩、アルカリ性物質及び特定の第四級アンモニウム塩型カチオン界面活性剤を、それぞれ特定の重量比で含有する液体殺菌漂白剤組成物が、特開平７−２３３３９６号には、次亜塩素酸塩、陰イオン界面活性剤、アルカリ剤及びキレート剤を含有する人工透析機等の医療機器用の殺菌洗浄剤が開示されている。
【０００３】
しかしながら、従来の次亜塩素酸塩系殺菌剤は、一般細菌やカビ（菌糸）についてはある程度の効果があるものの、薬品耐性のより高いウイルス、桿菌の形成する芽胞、カビ胞子に対しては簡易な操作では十分な効果が期待できない。
【０００４】
また、特開平１１−１４８０９８号には高度さらし粉（次亜塩素酸カルシウム）のような次亜塩素酸アルカリ土類金属塩を用いた固形殺菌洗浄剤が開示されているが、より高度の殺菌処理について認識されておらず、しかもカルシウム等のアルカリ土類金属がスケール、スカムの発生原因となり、殺菌効率の低下をもたらす。
【０００５】
なお、特開昭５９−９３７９９号には、アミンオキサイドを、次亜塩素酸塩を含有する液体洗浄剤に配合することが、また、特開昭５９−９８２００号には、アミンオキサイドを、次亜塩素酸塩を含有する漂白剤の増粘剤として用いることが開示されているが、これらには殺菌、特に耐性の高い芽胞やウイルスの殺菌に関しての言及はない。
【０００６】
本発明は、簡易な処理により、高い殺菌効果が得られ、且つ安全性、作業性に優れた殺菌剤組成物を得ることを目的とする。
【０００７】
【課題を解決するための手段】
本発明は、次亜塩素酸塩（Ａ）とアミンオキサイド（Ｂ）とを、（Ａ）／（Ｂ）＝１０／１〜１／１０の重量比で含有する殺菌剤組成物、更に有機酸又はその塩（Ｃ）を含有する該殺菌剤組成物に関する。
【０００８】
また、本発明は、次亜塩素酸塩（Ａ）を含む成分の製品（Ｉ）と、アミンオキサイド（Ｂ）を含む成分の製品（ＩＩ）とからなり、使用時に（Ａ）／（Ｂ）＝１０／１〜１／１０の重量比で含有する水溶液として用いられる殺菌剤に関する。
【０００９】
また、本発明は、次亜塩素酸塩（Ａ）を含む成分の製品（ＩＩＩ）とアミンオキサイド（Ｂ）と有機酸又はその塩（Ｃ）を含む成分の製品（ＩＶ）とからなり、使用時に（Ａ）／（Ｂ）＝１０／１〜１／１０の重量比で含有する水溶液として用いられる殺菌剤に関する。
【００１０】
更に本発明は、次亜塩素酸塩（Ａ）とアミンオキサイド（Ｂ）とを含む成分の製品（Ｖ）と、有機酸又はその塩（Ｃ）を含む成分の製品（ＶＩ）とからなり、使用時に（Ａ）／（Ｂ）＝１０／１〜１／１０の重量比で含有する水溶液として用いられる殺菌剤に関する。
【００１１】
【発明の実施の形態】
本発明に用いられる次亜塩素酸塩（Ａ）としては、次亜塩素酸ナトリウム、次亜塩素酸カリウム、次亜塩素酸リチウム等が挙げられるが、次亜塩素酸ナトリウムが好ましい。
【００１２】
本発明に用いられるアミンオキサイド（Ｂ）としては、アルキルジメチルアミンオキサイドが挙げられ、特に炭素数８〜１８のアルキル基を有するものが好ましい。
【００１３】
本発明の殺菌剤組成物は、次亜塩素酸塩（Ａ）とアミンオキサイド（Ｂ）とを、（Ａ）／（Ｂ）＝１０／１〜１／１０、好ましくは５／１〜１／５、より好ましくは２／１〜１／２の重量比で含有する。
【００１４】
ただし、（Ａ）成分は有効塩素基準での重量を示す。
【００１５】
本発明の殺菌剤組成物は、殺菌性能向上の観点から、更に有機酸又はその塩（Ｃ）を含有することが好ましい。有機酸又はその塩（Ｃ）としては、マロン酸、コハク酸、グルタル酸、アジピン酸、セバシン酸等の飽和二塩基酸又はその塩や、フマル酸、マレイン酸等の不飽和二塩基酸又はその塩等が挙げられる。好ましくは飽和二塩基酸又はその塩、より好ましくは炭素数３〜１０の飽和二塩基酸又はその塩であり、特にコハク酸又はその塩が好ましい。有機酸又はその塩（Ｃ）は、次亜塩素酸塩（Ａ）との重量比が（Ｃ）／（Ａ）＝５／１〜１／１０、更に２／１〜１／５、特に１／１〜１／５となるように用いられるのが好ましい。
【００１６】
本発明の殺菌剤組成物は、アルカリ金属の水酸化物及び／又はアルカリ土類金属の水酸化物（Ｄ）を含有してもよい。（Ｄ）としては、例えば水酸化ナトリウム、水酸化カリウム、水酸化カルシウム等が挙げられ、水酸化ナトリウム、水酸化カリウムが好ましい。
【００１７】
また、本発明の殺菌剤組成物は、無機酸のアルカリ金属塩及び／又は無機酸のアルカリ土類金属塩（Ｅ）を含有してもよい。（Ｅ）成分としては硫酸ナトリウム、硝酸ナトリウム、塩化ナトリウム、炭酸ナトリウム、炭酸水素ナトリウム、硫酸マグネシウム、硝酸マグネシウム、塩化マグネシウム、炭酸マグネシウム、リン酸ナトリウム、ポリリン酸ナトリウム、リン酸カリウム等が挙げられ、硫酸ナトリウム、硫酸マグネシウム、リン酸ナトリウム、ポリリン酸ナトリウム、リン酸カリウムが好ましい。
【００１８】
本発明の殺菌剤組成物は、上記（Ａ）成分と（Ｂ）成分とを特定重量比で含有する水溶液からなる。この水溶液の有効塩素濃度は５〜５０００ｐｐｍ、特に５０〜２００ｐｐｍが好ましい。また、水溶液のｐＨ（２５℃）は好ましくは５〜１２、より好ましくは５〜１０、更に好ましくは５〜８、特に好ましくは５以上７未満、更に特に好ましくは６以上７未満である。水溶液のｐＨの調整は上記有機酸又はその塩（Ｃ）や無機酸により行うことができる。また、本発明の殺菌剤組成物となる水溶液中の各成分の量は、（Ａ）成分が５ｐｐｍ〜１２重量％、（Ｂ）成分が０．５ｐｐｍ〜３５重量％が好ましく、（Ｃ）成分を配合する場合は、０．５ｐｐｍ〜６０重量％が好ましい。使用にあたっては、この水溶液を更に希釈した水溶液が用いられるが、この希釈水溶液は、（Ａ）成分を５〜５０００ｐｐｍ、更に１０〜５０００ｐｐｍ、特に５０〜２００ｐｐｍ、（Ｂ）成分を０．５〜５００００ｐｐｍ、更に５〜２０００ｐｐｍ、特に５０〜２００ｐｐｍ、（Ｃ）成分を０．５〜２５０００ｐｐｍ、更に５〜１０００ｐｐｍ、更にまた２５〜５００ｐｐｍ、特に２５〜１５０ｐｐｍ含有することが好ましい。なお、本発明の殺菌剤組成物の対象となる微生物とは、一般細菌、糸状菌、ウイルス、カビ胞子、細菌芽胞等を意味する。
【００１９】
本発明の殺菌剤組成物は、殺菌スペクトルが広く、細菌（カビ）のみならず、ウイルスや芽胞に対する効果も高いため、幅広い分野での殺菌に有用である。例えば、病院、養護施設、食品加工工場、クリーニング施設、厨房等の壁、床、窓等あるいはそれらで用いられる器具、備品、及び製品用（例えば飲料液用）容器等の殺菌に用いられる。
【００２０】
本発明の殺菌剤は、次亜塩素酸塩（Ａ）を含む成分の製品（Ｉ）とアミンオキサイド（Ｂ）を含む成分の製品（ＩＩ）とからなり、使用時に（Ａ）／（Ｂ）＝１０／１〜１／１０の重量比で含有する水溶液として用いられる。それぞれの製品には安定性等を損なわない限り任意成分を含んでいても良い。また、製品（Ｉ）、（ＩＩ）と、更にこれら以外の製品により構成されていてもよい。
【００２１】
また、有機酸又はその塩（Ｃ）を用いる場合は、次亜塩素酸塩（Ａ）とは別に配合することが好ましい。その具体例として、次亜塩素酸塩（Ａ）を含む成分の製品（ＩＩＩ）とアミンオキサイド（Ｂ）と有機酸又はその塩（Ｃ）を含む成分の製品（ＩＶ）とからなり、使用時に（Ａ）／（Ｂ）＝１０／１〜１／１０の重量比で含有する水溶液として用いられる殺菌剤が挙げられる。この殺菌剤は、使用時に（Ａ）成分と（Ｃ）成分を、（Ｃ）／（Ａ）＝５／１〜１／１０、更に２／１〜１／５、特に１／１〜１／５の重量比で含有する水溶液として用いられるのが好ましい。また、次亜塩素酸塩（Ａ）とアミンオキサイド（Ｂ）とを含む成分の製品（Ｖ）と、有機酸又はその塩（Ｃ）を含む成分の製品（ＶＩ）とからなり、使用時に（Ａ）／（Ｂ）＝１０／１〜１／１０の重量比で含有する水溶液として用いられる殺菌剤が挙げられる。この殺菌剤は、使用時に（Ａ）成分と（Ｃ）成分を、（Ｃ）／（Ａ）＝５／１〜１／１０、更に２／１〜１／５、特に１／１〜１／５の重量比で含有する水溶液として用いられるのが好ましい。それぞれの製品には安定性等を損なわない限り任意成分を含んでいても良い。また、製品（ＩＩＩ）〜（ＶＩ）と、更にこれら以外の製品により構成されていてもよい。
【００２２】
製品（Ｉ）〜（ＶＩ）の形態は限定されず、好ましくはガラス、金属、プラスチック、紙等の材質を用いた種々の包装容器に各成分を充填したものである。また、製品（Ｉ）〜（ＶＩ）の内容物はそのままでも、あるいは希釈して用いることができる。各製品中の有効分の濃度は、製品（Ｉ）では次亜塩素酸塩が０．１〜１２重量％、（ＩＩ）ではアミンオキサイドが０．１〜３５重量％、（ＩＩＩ）では次亜塩素酸塩が０．１〜１２重量％、（ＩＶ）ではアミンオキサイドと有機酸又はその塩との合計が０．２〜６０重量％、（Ｖ）では次亜塩素酸塩とアミンオキサイドの合計が０．２〜４７重量％、（ＶＩ）では有機酸又はその塩が０．１〜６０重量％が好ましい。
【００２３】
これら、製品（Ｉ）と（ＩＩ）、又は製品（ＩＩＩ）と（ＩＶ）、又は製品（Ｖ）と（ＶＩ）とから本発明の殺菌剤組成物を調製することができる。
【００２４】
【発明の効果】
本発明によれば、殺菌効果が高く、且つ安全性、作業性に優れた殺菌剤組成物が得られる。
【００２５】
【実施例】
実施例１〜６及び比較例１〜４
表１に示す組成の成分からなる水溶液を用いて、以下の試験を行った。結果を表１に示す。
【００２６】
なお、実施例１の配合成分は、次亜塩素酸ナトリウム水溶液（有効塩素濃度６００００ｐｐｍ）とアミンオキサイド（有効分３５％）を用い、それぞれ最終配合濃度の２倍までイオン交換水で希釈したものを等量混合して得たものである。また、実施例２〜４の配合成分は、次亜塩素酸ナトリウム水溶液（有効塩素濃度６００００ｐｐｍ）とアミンオキサイドを所定量混合し得られたものを最終配合濃度の２倍までイオン交換水で希釈したものとコハク酸を最終配合濃度の２倍までイオン交換水で希釈したものを等量混合して得たものである。また、実施例５、６の配合成分は、次亜塩素酸ナトリウム水溶液（有効塩素濃度６００００ｐｐｍ）を最終濃度の２倍までイオン交換水で希釈したものと、アミンオキサイドとコハク酸を所定量混合し得られたものを最終配合濃度の２倍までイオン交換水で希釈したものとを等量混合して得たものである。
【００２７】
〔１〕殺芽胞試験
芽胞菌として、▲１▼セレウス菌（ＢａｃｉｌｌｕｓｃｅｒｅｕｓＩＦＯ１３４９４）、▲２▼枯草菌（ＢａｃｉｌｌｕｓｓｕｂｔｉｌｉｓＡＴＣＣ６０５１）を用い、定法により熱処理を行い、得られた芽胞を試験に供した。すなわち、ＳＣＤ寒天培地（日本製薬（株）製）に前培養した菌を一白金耳かきとり、１ｍｌの滅菌水に懸濁し、６５℃、３０分間の熱処理後、２回遠心分離洗浄を行ったものを試験に用いた。
【００２８】
この試験用芽胞菌液（約１０^９〜１０^１０ｃｅｌｌ／ｍｌ）を０．１ｍｌとり、表１の成分からなる水溶液を更に滅菌したイオン交換水で稀釈した水溶液（温度２５℃）１０ｍｌに１０秒間接触させた後、５０μｌを採取し、後培養用ＳＣＤＬＰ培地（チオ硫酸ナトリウム３．３％含有）０．２ｍｌの入ったミクロシャーレ（ＣＯＲＮＩＮＧ社製、９６−ＣｅｌｌＷｅｌｌｓ）へ接種した。３０℃で４８時間培養し、菌の発育を肉眼で観察し、ミクロシャーレ上で菌が生育しているかどうかを観察し、菌の生育がない（つまり１００％殺菌できる）最小の希釈倍率（最小殺菌有効塩素濃度）を求めた。なお、有効塩素濃度は、ＪＩＳＫ−０１０１“ヨウ素法”により測定したものである。
【００２９】
〔２〕殺カビ試験
被験菌としてカビ（真菌、ＡｓｐｅｒｇｉｌｌｕｓｎｉｇｅｒＩＦＯ６３４１）は、ＰＤＡ培地を用い、２５℃で７日間培養した。得られた菌体をガラス玉法を用い、均一にした後、滅菌ガーゼで異物を除去し、菌液を得た。この菌液（約１０^９〜１０^１０ｃｅｌｌ／ｍｌ）を０．１ｍｌとり、表１の成分からなる水溶液を更に滅菌したイオン交換水で表１に示す倍率で稀釈した水溶液（温度２５℃）１０ｍｌに１０秒間接触させた後、０．１ｍｌを採取し、後培養用ＰＤＡ培地（チオ硫酸ナトリウム３．３％含有）へ接種した。２５℃で７時間培養し、菌の発育を肉眼で観察し、上記同様に評価した。
【００３０】
【表１】

【００３１】
実施例７〜１０
表２の成分からなる水溶液をイオン交換水で表２に示す倍率で希釈した試験用水溶液（有効塩素濃度２００ｐｐｍ）を調製し、サンプルビンに密閉後、４０℃の恒温槽で２日間保存した。なお、この水溶液は、次亜塩素酸ナトリウム水溶液（有効塩素濃度６００００ｐｐｍ）を最終配合濃度の２倍までイオン交換水で希釈したものと、アミンオキサイドと有機酸とを所定量混合し得られたものを最終配合濃度の２倍までイオン交換水で希釈したものを等量混合して得たものである。
【００３２】
２日後にサンプルビンを取り出し、試験用水溶液の有効塩素濃度を測定し、有効塩素濃度の保持率（％）を次の式により求めた。結果を表２に示す。
保持率（％）＝〔４０℃で２日保存後の有効塩素濃度／２００〕×１００
【００３３】
【表２】

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a fungicide composition.
[0002]
[Prior art and problems to be solved by the invention]
Conventionally, chlorine-based disinfectants such as sodium hypochlorite, calcium hypochlorite, and sodium dichloroisocyanurate have been widely used as disinfectants in a wide range of environments. Among them, hypochlorite such as sodium hypochlorite is widely used in terms of price and effect, but for sterilization and sterilization of microorganisms required in various fields such as medical and food industries, Furthermore, many proposals have been made to improve its effectiveness. For example, JP-A-57-61099 discloses a liquid sterilizing bleaching composition containing hypochlorite, an alkaline substance, and a specific quaternary ammonium salt type cationic surfactant in specific weight ratios. JP-A-7-233396 discloses a bactericidal cleaning agent for medical devices such as an artificial dialysis machine containing hypochlorite, an anionic surfactant, an alkali agent and a chelating agent.
[0003]
However, although conventional hypochlorite fungicides have some effects on general bacteria and mold (mycelium), they are easy for viruses with higher chemical resistance, spores formed by gonococci, and mold spores. A sufficient operation cannot be expected.
[0004]
Japanese Patent Application Laid-Open No. 11-148098 discloses a solid sterilizing detergent using an alkaline earth metal hypochlorite such as highly bleached powder (calcium hypochlorite). In addition, alkaline earth metals such as calcium cause scales and scum, resulting in a decrease in sterilization efficiency.
[0005]
In JP-A-59-93799, amine oxide is added to a liquid detergent containing hypochlorite, and in JP-A-59-98200, amine oxide is added as follows. Although they are disclosed for use as thickeners for bleach containing chlorite, there is no mention of sterilization, particularly sterilization of highly resistant spores and viruses.
[0006]
It is an object of the present invention to obtain a bactericidal composition having a high bactericidal effect and excellent safety and workability by a simple treatment.
[0007]
[Means for Solving the Problems]
The present invention relates to a disinfectant composition containing hypochlorite (A) and amine oxide (B) in a weight ratio of (A) / (B) = 10/1 to 1/10, and further an organic acid Or it relates to the fungicide composition containing the salt (C).
[0008]
Further, the present invention comprises a product (I) having a component containing hypochlorite (A) and a product (II) having a component containing amine oxide (B), and (A) / (B) during use. = It relates to a disinfectant used as an aqueous solution containing a weight ratio of 10/1 to 1/10.
[0009]
Further, the present invention comprises a product (III) of a component containing hypochlorite (A) and a product (IV) of a component containing an amine oxide (B) and an organic acid or a salt thereof (C). It relates to a disinfectant used as an aqueous solution sometimes containing (A) / (B) = 10/1 to 1/10 by weight.
[0010]
Furthermore, the present invention comprises a product (V) of a component containing hypochlorite (A) and an amine oxide (B), and a product (VI) of a component containing an organic acid or a salt thereof (C), The present invention relates to a disinfectant used as an aqueous solution containing at a weight ratio of (A) / (B) = 10/1 to 1/10 during use.
[0011]
DETAILED DESCRIPTION OF THE INVENTION
Examples of the hypochlorite (A) used in the present invention include sodium hypochlorite, potassium hypochlorite, lithium hypochlorite and the like, and sodium hypochlorite is preferred.
[0012]
Examples of the amine oxide (B) used in the present invention include alkyldimethylamine oxide, and those having an alkyl group having 8 to 18 carbon atoms are particularly preferable.
[0013]
The disinfectant composition of the present invention comprises hypochlorite (A) and amine oxide (B), wherein (A) / (B) = 10/1 to 1/10, preferably 5/1 to 1 /. 5, More preferably, it is contained in a weight ratio of 2/1 to 1/2.
[0014]
However, (A) component shows the weight on an effective chlorine basis.
[0015]
The fungicidal composition of the present invention preferably further contains an organic acid or a salt thereof (C) from the viewpoint of improving the bactericidal performance. Examples of organic acids or salts thereof (C) include saturated dibasic acids such as malonic acid, succinic acid, glutaric acid, adipic acid, and sebacic acid, or salts thereof, unsaturated dibasic acids such as fumaric acid, maleic acid, and the like. Examples include salts. A saturated dibasic acid or a salt thereof is preferable, a saturated dibasic acid having 3 to 10 carbon atoms or a salt thereof is preferable, and a succinic acid or a salt thereof is particularly preferable. The organic acid or a salt thereof (C) has a weight ratio to the hypochlorite (A) of (C) / (A) = 5/1 to 1/10, more preferably 2/1 to 1/5, particularly 1 It is preferable to use it so that it becomes / 1 to 1/5.
[0016]
The disinfectant composition of the present invention may contain an alkali metal hydroxide and / or an alkaline earth metal hydroxide (D). Examples of (D) include sodium hydroxide, potassium hydroxide, calcium hydroxide and the like, and sodium hydroxide and potassium hydroxide are preferable.
[0017]
Moreover, the disinfectant composition of the present invention may contain an alkali metal salt of an inorganic acid and / or an alkaline earth metal salt (E) of an inorganic acid. Examples of the component (E) include sodium sulfate, sodium nitrate, sodium chloride, sodium carbonate, sodium hydrogen carbonate, magnesium sulfate, magnesium nitrate, magnesium chloride, magnesium carbonate, sodium phosphate, sodium polyphosphate, and potassium phosphate. Sodium sulfate, magnesium sulfate, sodium phosphate, sodium polyphosphate, and potassium phosphate are preferred.
[0018]
The disinfectant composition of the present invention comprises an aqueous solution containing the component (A) and the component (B) at a specific weight ratio. The effective chlorine concentration of this aqueous solution is preferably 5 to 5000 ppm, particularly 50 to 200 ppm. The pH (25 ° C.) of the aqueous solution is preferably 5 to 12, more preferably 5 to 10, still more preferably 5 to 8, particularly preferably 5 to less than 7, and still more preferably 6 to less than 7. Adjustment of pH of aqueous solution can be performed with the said organic acid or its salt (C), and an inorganic acid. In addition, the amount of each component in the aqueous solution used as the bactericide composition of the present invention is preferably 5 ppm to 12% by weight for component (A), 0.5 ppm to 35% by weight for component (B), and component (C). Is preferably 0.5 ppm to 60% by weight. In use, an aqueous solution obtained by further diluting this aqueous solution is used. This diluted aqueous solution has a component (A) of 5-5000 ppm, further 10-5000 ppm, particularly 50-200 ppm, and (B) component of 0.5-50000 ppm. Further, it is preferable to contain 5 to 2000 ppm, particularly 50 to 200 ppm, and component (C) 0.5 to 25000 ppm, further 5 to 1000 ppm, more preferably 25 to 500 ppm, particularly 25 to 150 ppm. In addition, the microorganisms targeted by the fungicide composition of the present invention mean general bacteria, filamentous fungi, viruses, mold spores, bacterial spores and the like.
[0019]
Since the bactericidal composition of the present invention has a wide bactericidal spectrum and a high effect on not only bacteria (mold) but also viruses and spores, it is useful for sterilization in a wide range of fields. For example, it is used for the sterilization of hospitals, nursing homes, food processing factories, cleaning facilities, kitchen walls, floors, windows, etc., or equipment, fixtures, and product (for example, beverage) containers used therein.
[0020]
The disinfectant of the present invention comprises a product (I) having a component containing hypochlorite (A) and a product (II) having a component containing amine oxide (B). When used, (A) / (B) = Used as an aqueous solution containing a weight ratio of 10/1 to 1/10. Each product may contain optional components as long as the stability and the like are not impaired. Moreover, you may be comprised with products (I) and (II) and products other than these.
[0021]
Moreover, when using organic acid or its salt (C), it is preferable to mix | blend separately from hypochlorite (A). Specific examples thereof include a product (III) of a component containing hypochlorite (A) and a product (IV) of a component containing amine oxide (B) and an organic acid or a salt thereof (C). (A) / (B) = The disinfectant used as an aqueous solution contained in a weight ratio of 10/1 to 1/10 is mentioned. This bactericidal agent is used when the component (A) and the component (C) are converted into (C) / (A) = 5/1 to 1/10, further 2/1 to 1/5, particularly 1/1 to 1 / It is preferably used as an aqueous solution containing 5 by weight. Moreover, it consists of a product (V) of a component containing hypochlorite (A) and an amine oxide (B) and a product (VI) of a component containing an organic acid or a salt thereof (C). A) / (B) = bactericides used as an aqueous solution containing at a weight ratio of 10/1 to 1/10. This bactericidal agent is used when the component (A) and the component (C) are converted into (C) / (A) = 5/1 to 1/10, further 2/1 to 1/5, particularly 1/1 to 1 / It is preferably used as an aqueous solution containing 5 by weight. Each product may contain optional components as long as the stability and the like are not impaired. Moreover, you may be comprised by products (III)-(VI) and products other than these further.
[0022]
The form of the products (I) to (VI) is not limited and is preferably a product in which various components are filled in various packaging containers made of glass, metal, plastic, paper, or the like. The contents of the products (I) to (VI) can be used as they are or after being diluted. The concentration of the effective component in each product is 0.1 to 12% by weight of hypochlorite in product (I), 0.1 to 35% by weight of amine oxide in (II), and hypochlorous in (III). 0.1 to 12% by weight of chlorate, (IV) is 0.2 to 60% by weight of the sum of amine oxide and organic acid or salt thereof, and (V) is the sum of hypochlorite and amine oxide Is 0.2 to 47% by weight, and in (VI) the organic acid or salt thereof is preferably 0.1 to 60% by weight.
[0023]
From these products (I) and (II), products (III) and (IV), or products (V) and (VI), the fungicidal composition of the present invention can be prepared.
[0024]
【The invention's effect】
According to the present invention, a bactericidal composition having a high bactericidal effect and excellent safety and workability can be obtained.
[0025]
【Example】
Examples 1-6 and Comparative Examples 1-4
The following tests were performed using an aqueous solution composed of the components shown in Table 1. The results are shown in Table 1.
[0026]
In addition, the compounding component of Example 1 used what was diluted with ion-exchange water to twice the final compounding concentration, respectively, using sodium hypochlorite aqueous solution (effective chlorine concentration 60000 ppm) and amine oxide (effective component 35%). It was obtained by mixing equal amounts. In addition, the compounding components of Examples 2 to 4 were obtained by mixing a predetermined amount of sodium hypochlorite aqueous solution (effective chlorine concentration 60000 ppm) and amine oxide, diluted with ion-exchanged water to twice the final compounding concentration. It was obtained by mixing equal amounts of succinic acid and succinic acid diluted with ion-exchanged water up to twice the final blending concentration. In addition, the components of Examples 5 and 6 were prepared by mixing a sodium hypochlorite aqueous solution (effective chlorine concentration 60,000 ppm) with ion-exchanged water up to twice the final concentration, and a predetermined amount of amine oxide and succinic acid. The obtained product was obtained by mixing an equal amount of the product diluted with ion-exchanged water up to twice the final blending concentration.
[0027]
[1] Spore killing test As (1) Bacillus cereus IFO13494 and (2) Bacillus subtilis (Bacillus subtilis ATCC6051), the spore obtained was subjected to heat treatment by a conventional method and subjected to the test. That is, a pre-cultured bacterium on an SCD agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.) was scraped from one platinum ear, suspended in 1 ml of sterilized water, heat-treated at 65 ° C. for 30 minutes, and then centrifuged and washed twice. Was used for the test.
[0028]
Take 0.1 ml of this test spore solution (about 10 ⁹ to 10 ¹⁰ cells / ml) and dilute the aqueous solution comprising the components in Table 1 with further sterilized ion-exchanged water (temperature 25 ° C.) in 10 ml for 10 seconds. After contact, 50 μl was collected and inoculated into a micro petri dish (CORNING, 96-Cell Wells) containing 0.2 ml of a post-culture SCDLP medium (containing 3.3% sodium thiosulfate). Incubate at 30 ° C for 48 hours, observe the growth of bacteria with the naked eye, observe whether the bacteria are growing on a micro petri dish, and do not grow (that is, 100% can be sterilized). Bactericidal effective chlorine concentration) was determined. The effective chlorine concentration is measured by JIS K-0101 “iodine method”.
[0029]
[2] Fungicidal test Mold (Fungus, Aspergillus niger IFO6341) as a test bacterium was cultured at 25 ° C. for 7 days using a PDA medium. The obtained cells were homogenized using a glass ball method, and then foreign substances were removed with sterilized gauze to obtain a bacterial solution. ¹⁰ ml of an aqueous solution (temperature: 25 ° C.) obtained by diluting 0.1 ml of this bacterial solution (about 10 ⁹ to 10 ¹⁰ cells / ml) and further diluting the aqueous solution comprising the components of Table 1 with sterilized ion-exchanged water at the magnification shown in Table 1. After 10 minutes, 0.1 ml was collected and inoculated into a PDA medium for post-culture (containing 3.3% sodium thiosulfate). After culturing at 25 ° C. for 7 hours, the growth of the bacteria was observed with the naked eye and evaluated in the same manner as described above.
[0030]
[Table 1]

[0031]
Examples 7-10
A test aqueous solution (effective chlorine concentration 200 ppm) was prepared by diluting an aqueous solution composed of the components shown in Table 2 with ion-exchanged water at the magnification shown in Table 2, and after sealing in a sample bottle, it was stored in a constant temperature bath at 40 ° C. for 2 days. In addition, this aqueous solution was obtained by mixing a predetermined amount of an aqueous solution of sodium hypochlorite (effective chlorine concentration 60000 ppm) diluted with ion-exchanged water up to twice the final blending concentration, and amine oxide. Is obtained by mixing an equal amount of the product diluted with ion-exchanged water up to twice the final blending concentration.
[0032]
Two days later, the sample bottle was taken out, the effective chlorine concentration of the aqueous test solution was measured, and the retention rate (%) of the effective chlorine concentration was determined by the following formula. The results are shown in Table 2.
Retention rate (%) = [effective chlorine concentration after storage at 40 ° C. for 2 days / 200] × 100
[0033]
[Table 2]

Claims

Hypochlorite (A) and amine oxide (B) selected from sodium hypochlorite, potassium hypochlorite and lithium hypochlorite, (A) / (B) = 10/1 to 1 A liquid disinfectant composition comprising an aqueous solution having a pH (25 ° C.) of 5 to 8 and contained at a weight ratio of / 10.

The fungicidal composition according to claim 1, comprising an organic acid or a salt thereof (C).

The fungicidal composition according to claim 2, wherein the organic acid or a salt thereof (C) is a saturated dibasic acid or a salt thereof.

The fungicidal composition according to claim 2 or 3, wherein the weight ratio of the organic acid or a salt thereof (C) to the hypochlorite (A) is (C) / (A) = 5/1 to 1/10. .

Product of component (I) containing hypochlorite (A) selected from sodium hypochlorite, potassium hypochlorite and lithium hypochlorite, and product of component containing amine oxide (B) (II And used as an aqueous solution having a pH (25 ° C.) of 5 to 8 which is contained at a weight ratio of (A) / (B) = 10/1 to 1/10 at the time of use.

Product (III) of component containing hypochlorite (A) selected from sodium hypochlorite, potassium hypochlorite and lithium hypochlorite, amine oxide (B) and organic acid or salt thereof (C Sterilized and used as an aqueous solution having a pH (25 ° C.) of 5 to 8 which is contained in a weight ratio of (A) / (B) = 10/1 to 1/10 at the time of use. Agent.

Product (V) of component containing hypochlorite (A) and amine oxide (B) selected from sodium hypochlorite, potassium hypochlorite and lithium hypochlorite, and organic acid or salt thereof It is composed of a product (VI) containing the component (C), and is used as an aqueous solution having a pH (25 ° C.) of 5 to 8 and contained at a weight ratio of (A) / (B) = 10/1 to 1/10 at the time of use. Disinfectant.