CN114514926A - Broad-spectrum disinfectant - Google Patents
Broad-spectrum disinfectant Download PDFInfo
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- CN114514926A CN114514926A CN202210061971.1A CN202210061971A CN114514926A CN 114514926 A CN114514926 A CN 114514926A CN 202210061971 A CN202210061971 A CN 202210061971A CN 114514926 A CN114514926 A CN 114514926A
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- disinfectant
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- alcohol
- tetrafluoroethane
- propellant
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 91
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 51
- 239000003380 propellant Substances 0.000 claims abstract description 47
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 claims abstract description 42
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 claims abstract description 42
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 32
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims abstract description 30
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- 235000013599 spices Nutrition 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 34
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 22
- 239000011259 mixed solution Substances 0.000 claims description 12
- 229960004063 propylene glycol Drugs 0.000 claims description 11
- 241000588724 Escherichia coli Species 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical group CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 7
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 7
- 238000001228 spectrum Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 238000011049 filling Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000003825 pressing Methods 0.000 claims description 5
- 241000700605 Viruses Species 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims description 3
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 3
- 241000228245 Aspergillus niger Species 0.000 claims description 3
- 241000222122 Candida albicans Species 0.000 claims description 3
- 241000711573 Coronaviridae Species 0.000 claims description 3
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 claims description 3
- 241000194033 Enterococcus Species 0.000 claims description 3
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 claims description 3
- 241000186367 Mycobacterium avium Species 0.000 claims description 3
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 3
- 241000191967 Staphylococcus aureus Species 0.000 claims description 3
- 229940095731 candida albicans Drugs 0.000 claims description 3
- 229960005233 cineole Drugs 0.000 claims description 3
- 229940117916 cinnamic aldehyde Drugs 0.000 claims description 3
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims description 3
- 208000006454 hepatitis Diseases 0.000 claims description 3
- 231100000283 hepatitis Toxicity 0.000 claims description 3
- 206010022000 influenza Diseases 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000019634 flavors Nutrition 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 230000000994 depressogenic effect Effects 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 10
- -1 quaternary ammonium salt compound Chemical class 0.000 abstract description 8
- 150000001875 compounds Chemical class 0.000 abstract description 7
- 230000002195 synergetic effect Effects 0.000 abstract description 7
- 230000002528 anti-freeze Effects 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 24
- 230000000844 anti-bacterial effect Effects 0.000 description 11
- 230000001954 sterilising effect Effects 0.000 description 10
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- 244000005700 microbiome Species 0.000 description 6
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000002147 killing effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 235000012431 wafers Nutrition 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
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- 238000007865 diluting Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
- 238000013095 identification testing Methods 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
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- 241000192125 Firmicutes Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 231100000460 acute oral toxicity Toxicity 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
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- 230000037396 body weight Effects 0.000 description 1
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- 238000000576 coating method Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000006286 nutrient intake Nutrition 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A broad spectrum disinfectant relates to the technical field of disinfectants, and comprises the following components: quaternary ammonium salt disinfectant component: 0.2 to 0.4 percent; 1,1,1, 2-tetrafluoroethane: 80-81%; alcohol propellant: 16 to 18 percent; alcohol antifreezing agent: 1.4-2.8%; dimethyl sulfoxide: 0.1 to 0.2 percent; essence and spice: 0.4 to 0.8 percent; the quaternary ammonium salt disinfectant adopts a high-efficiency double-chain quaternary ammonium salt compound, and adopts didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium chloride as main disinfection raw materials, and the didecyl dimethyl ammonium chloride are synergistic, and form a novel compound formula with other propellants, antifreeze and the like on the basis to achieve a more ideal disinfection effect.
Description
Technical Field
The invention relates to the technical field of disinfectants, in particular to a broad-spectrum disinfectant.
Background
Many compounds that function as disinfectants are known in the biomedical sterilization art. However, disinfectants differ in their ability to kill different microorganisms. For example, some compounds may function only as fungicides, others as virucidal agents, and still others as fungicides. Some compounds are known which can kill gram positive bacteria, but are ineffective in killing gram negative bacteria. Thus, to provide a broad spectrum disinfectant, a disinfectant that is effective at killing most, if not all, microorganisms may require a combination of known disinfectants with complementary activities.
The multifunctional broad-spectrum disinfectant belongs to a disinfectant product with wider applicability in the field of biological medicine disinfection, and is mainly suitable for disinfection, cleaning and sanitation of houses, buildings, hospitals, hotels, schools, nursery houses, catering services, public entertainment places, food processing industry, disinfection of surfaces of human bodies, animals and objects, disinfection and sterilization of microorganisms of surgical instruments, and disinfection, cleaning and sanitation of surrounding environments of buildings with intensive living activities of various crowds, livestock and poultry. The prior application numbers CN200310109106.7 and CN02829642.7 respectively disclose a multi-element synergistic multifunctional broad-spectrum disinfectant and a broad-spectrum disinfectant, and the formula of the multi-element synergistic multifunctional broad-spectrum disinfectant comprises (1) 0.05 to 4.5 weight percent of antimicrobial agent, (2) 0.005 to 0.5 weight percent of quaternary ammonium salt compound, (3) 0.025 to 3 weight percent of chlorophenol compound, and (4) 92 to 99.9 weight percent of alcohol. The spectrum disinfectant can only be applied to daily disinfection scenes such as soap, cosmetics and wet tissues, has a small application range and is in need of improvement.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a broad-spectrum disinfectant, and the specific scheme is as follows:
a wide spectrum disinfectant comprising the following components:
quaternary ammonium salt disinfectant component: 0.2 to 0.4 percent
1,1,1, 2-tetrafluoroethane: 80 to 81 percent
Alcohol propellant: 16-18 percent
Alcohol antifreezing agent: 1.4 to 2.8 percent
Dimethyl sulfoxide: 0.1 to 0.2 percent
Essence and spice: 0.4 to 0.8 percent
The quaternary ammonium salt disinfectant comprises didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium chloride.
Further, the alcohol propellant is isopropanol.
Further, the alcohol antifreezing agent comprises the following specific components:
1, 2-propylene glycol: 0.5-1.0%
2-methyl-2, 4-pentanediol: 0.5-1.0%
Glycerol: 0.4 to 0.8 percent
Further, the essence and flavor comprise one or more of eucalyptol, ethylene glycol phenyl ether, cinnamaldehyde and diphenyl ether.
Further, the spectrum disinfectant can be suitable for H1N1 virus and lipophilic virus represented by Ebola, coronavirus, influenza, hepatitis and AIDS virus, staphylococcus aureus, enterococcus, pseudomonas aeruginosa, escherichia coli, aspergillus niger, candida albicans, mycobacterium avium and mycobacterium tuberculosis.
Further, the production process of the disinfectant comprises the following steps:
the disinfectant is prepared by mixing and dissolving the components except 1,1,1, 2-tetrafluoroethane and alcohol propellant, filling the mixture into a reaction container at room temperature, installing and fastening a valve of the reaction container, and pressing the 1,1,1, 2-tetrafluoroethane and alcohol propellant into the reaction container by a press-fitting machine.
Further, the production process of the disinfectant comprises the following steps:
the disinfectant is characterized in that except 1,1,1, 2-tetrafluoroethane and an alcohol propellant, other components are mixed and dissolved to form a mixed solution, the mixed solution is cooled to the temperature of-18 to-22 ℃ by a cooling device, meanwhile, the 1,1,1, 2-tetrafluoroethane and the alcohol propellant are also cooled to the temperature of-18 to-22 ℃ by the cooling device, then the cooled mixed solution, the cooled 1,1,1, 2-tetrafluoroethane and the alcohol propellant are sequentially filled into a reaction container, or the cooled mixed solution, the cooled 1,1,1, 2-tetrafluoroethane and the alcohol propellant are filled into the reaction container, and a valve of the reaction container is immediately installed and fastened within 3-5 s.
The application of the broad spectrum disinfectant comprises the steps of preparing the broad spectrum disinfectant into liquid, storing the liquid in a bottle body with a valve, putting the bottle body in a place to be disinfected, pressing down the bottle body and rotating the valve to release the valve, generating a disinfection cloud cluster in 1-3 minutes by the bottle body, ensuring that the place to be disinfected is sealed for more than 1 hour after no one is present in the place to be disinfected, and ventilating the place to be disinfected.
Compared with the prior art, the invention has the following beneficial effects:
(1) in the broad-spectrum disinfectant, on the basis of taking quaternary ammonium salt disinfection components and essence and spice as aroma enhancement components, 1,1,1, 2-tetrafluoroethane is taken as a propellant and an alcohol propellant together as an injection power source, and can also be taken as a solvent or a diluent of a medicament, an alcohol antifreezing agent is taken as a component of the same family with the alcohol propellant, the disinfectant has antifreezing effect on the disinfectant on the premise of not influencing the normal action of the disinfection components and the propellant, and the dimethyl sulfoxide can be fully dissolved in the alcohol organic matters and can be mixed and dissolved with the alcohol propellant and the alcohol antifreezing agent to be used as the propellant and the penetrating agent, on the basis of playing a role in penetrating the disinfectant, the whole disinfectant simultaneously contains three different propellants, even if one propellant fails, the disinfectant can be sprayed normally for disinfection in actual use.
In detail, the quaternary ammonium salt disinfectant adopts a high-efficiency double-chain quaternary ammonium salt compound, and the didecyl dimethyl ammonium chloride are used as main disinfection raw materials, are synergistic, and form a novel compound formula with other propellants, antifreeze and the like on the basis to achieve a more ideal disinfection effect. The double-chain quaternary ammonium salt compound has the effects of being attributed to positive charges, the positive charges are combined with genes with negative charges on the cell wall of the microorganism to destroy the cell wall, the bacteriolysis effect and the cell death are caused, and the double-chain quaternary ammonium salt compound can also denature proteins of the microorganism to cause the cell death, destroy the semi-permeability of the cell membrane of the microorganism, and reduce the nutrient intake for maintaining the life.
(2) The alcohol antifreezing agent specifically adopts three compounds of 1, 2-propylene glycol, 2-methyl-2, 4-pentanediol and glycerol, and the three compounds are uniformly blended and synergized to achieve an antifreezing effect on a disinfectant.
(3) The broad-spectrum disinfectant is stored in the bottle body and then is a product for disinfecting the surface of an object through air release, can be completely released in one step by operating a disposable valve, can be sprayed out at a certain speed under the synergistic action of various propellants, and can reach an area which can hardly be reached by the traditional disinfectant.
The broad-spectrum disinfectant can quickly act on bacteria, fungi, mycobacteria and viruses, has long-acting disinfection effect for multiple days, can eliminate unpleasant odor caused by bacterial fermentation, is nontoxic and harmless, does not contain combustible gas and toxic components, and can be used in places where other products cannot be used. The material is completely compatible with all types of materials and electronic equipment in the using process, and does not cause any damage to medical equipment or electronic components.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.
A broad spectrum disinfectant, comprising the following components:
quaternary ammonium salt disinfectant component: 0.2 to 0.4 percent
1,1,1, 2-tetrafluoroethane: 80 to 81 percent
Alcohol propellant: 16-18 percent
Alcohol antifreezing agent: 1.4 to 2.8 percent
Dimethyl sulfoxide: 0.1 to 0.2 percent
Essence and spice: 0.4 to 0.8 percent
The quaternary ammonium salt disinfectant comprises didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium chloride.
Preferably, the alcohol propellant is isopropanol. The essence and spice comprises one or more of eucalyptol, ethylene glycol phenyl ether, cinnamaldehyde and diphenyl ether. The alcohol antifreezing agent comprises the following specific components:
1, 2-propylene glycol: 0.5-1.0%
2-methyl-2, 4-pentanediol: 0.5-1.0%
Glycerol (b): 0.4 to 0.8 percent
One of the characteristics of the broad spectrum disinfectant is broad spectrum disinfection, and the single-component double-long chain quaternary ammonium salt disinfectant with the main components of the didecyl dimethyl ammonium chloride and the didecyl dimethyl ammonium chloride also has strong sterilization capability and can independently kill bacterial propagules, yeasts and the like. Specifically, the recombinant DNA can be applied to H1N1 virus, lipophilic viruses such as Ebola, coronavirus, influenza, hepatitis and AIDS virus, staphylococcus aureus, enterococcus, pseudomonas aeruginosa, escherichia coli, aspergillus niger, candida albicans, mycobacterium avium and mycobacterium tuberculosis.
Therefore, the broad-spectrum disinfectant is an ideal choice for disinfecting the surface of an object, is suitable for a sealable space, can quickly reach places which are difficult to reach by a traditional disinfection mode, has excellent material compatibility, is non-toxic, non-corrosive and non-flammable, can be used as a disinfection product for medical/aviation, and can also be used in doctor rooms, moon centers, classrooms/office places, warehouses/cold rooms, military places, air-conditioning pipelines, kindergartens, nursery centers, airplanes, high-speed rails, motor cars, buses, private cars, laboratories and clean plants, and has a wide application range.
In addition, the invention also discloses two corresponding production processes aiming at the skin disinfectant, wherein the first production process specifically comprises the following steps:
the disinfectant is prepared by mixing and dissolving the components except 1,1,1, 2-tetrafluoroethane and alcohol propellant, filling the mixture into a reaction container at room temperature, installing and fastening a valve of the reaction container, and pressing the mixture into the 1,1,1, 2-tetrafluoroethane and alcohol propellant through a press-fitting machine.
The second production process is as follows:
the disinfectant is prepared by mixing and dissolving the components except 1,1,1, 2-tetrafluoroethane and alcohol propellant to form a mixed solution, cooling the mixed solution to-18 to-22 ℃ by virtue of a cooling device, simultaneously cooling the 1,1,1, 2-tetrafluoroethane and the alcohol propellant to-18 to-22 ℃ by virtue of the cooling device, then sequentially filling the cooled mixed solution, the cooled 1,1,1, 2-tetrafluoroethane and the alcohol propellant into a reaction container, or simultaneously filling the cooled mixed solution, the cooled 1,1,1, 2-tetrafluoroethane and the alcohol propellant into the reaction container, and immediately installing and fastening a valve of the reaction container within 3-5 s.
The two production processes are convenient to operate, do not relate to the use of large-scale equipment and energy consumption, and have wide application range.
The invention provides an application of a broad spectrum disinfectant, which is characterized in that the general quaternary ammonium salt disinfectant is used in a mode of manual spraying, wiping and the like, the broad spectrum disinfectant is prepared into liquid and stored in a bottle body provided with a valve, the bottle body is placed in a place to be disinfected, the valve is pressed and rotated to release, the bottle body generates a disinfection cloud cluster in 1-3 minutes, the place to be disinfected is kept sealed for more than 1 hour after no one is in the place to be disinfected, then the place to be disinfected is ventilated, and the whole process is convenient to use.
The second characteristic of the broad spectrum disinfectant of the invention is that the dead angle for disinfection is less, specifically, by the application method, the disinfectant gas is directly used or the disinfectant is vaporized to disinfect the whole environment (including the environment surface, air and articles), the disinfection effect can be achieved as long as the disinfectant can diffuse into the place, the disinfection is more thorough, and the dead angle is less.
The broad spectrum disinfectant of the present invention has the third characteristic of good material compatibility, specifically, the broad spectrum disinfectant does not contain combustible gas and toxic components, is classified as non-combustible, and passes stability test and metal surface corrosion test, and also passes test of influence on transparent plastic and test of influence on painted surface. Meets the requirements of the international standard of general aircraft disinfectant SAEAMS 1452.
Therefore, the present invention proposes embodiments 1 to 7 for the above, and the following are specific contents:
example 1
A broad spectrum disinfectant, comprising the following components:
didecyl dimethyl ammonium chloride: 0.3 percent of
1,1,1, 2-tetrafluoroethane: 80.2 percent
Alcohol propellant: 17 percent
1, 2-propylene glycol: 0.6 percent
2-methyl-2, 4-pentanediol: 0.7 percent
Glycerol: 0.6 percent
Dimethyl sulfoxide: 0.1 percent of
Essence and spice: 0.5 percent
Example 2
A broad spectrum disinfectant, comprising the following components:
didecyl dimethyl ammonium chloride: 0.3 percent of
1,1,1, 2-tetrafluoroethane: 80.2 percent
Alcohol propellant: 17 percent of
1, 2-propylene glycol: 0.6 percent
2-methyl-2, 4-pentanediol: 0.7 percent
Glycerol: 0.6 percent
Dimethyl sulfoxide: 0.1 percent of
Essence and spice: 0.5 percent
Example 3
A broad spectrum disinfectant, comprising the following components:
didecyl dimethyl ammonium chloride: 0.2 percent
Didecyl dimethyl ammonium chloride: 0.1 percent
1,1,1, 2-tetrafluoroethane: 80.2 percent
Alcohol propellant: 17 percent
1, 2-propylene glycol: 0.6 percent
2-methyl-2, 4-pentanediol: 0.7 percent
Glycerol: 0.6 percent
Dimethyl sulfoxide: 0.1 percent of
Essence and spice: 0.5 percent
Example 4
Didecyl dimethyl ammonium chloride: 0.1 percent of
Didecyl dimethyl ammonium chloride: 0.2 percent of
1,1,1, 2-tetrafluoroethane: 80.2 percent
Alcohol propellant: 17 percent of
1, 2-propylene glycol: 0.6 percent
2-methyl-2, 4-pentanediol: 0.7 percent
Glycerol: 0.6 percent
Dimethyl sulfoxide: 0.1 percent of
Essence and spice: 0.5 percent
Example 5
Didecyl dimethyl ammonium chloride: 0.15 percent
Didecyl dimethyl ammonium chloride: 0.15 percent
1,1,1, 2-tetrafluoroethane: 80.2 percent
Alcohol propellant: 17 percent of
1, 2-propylene glycol: 0.6 percent
2-methyl-2, 4-pentanediol: 0.7 percent
Glycerol: 0.6 percent
Dimethyl sulfoxide: 0.1 percent of
Essence and spice: 0.5 percent
Example 6
Didecyl dimethyl ammonium chloride: 0.3 percent of
1,1,1, 2-tetrafluoroethane: 80.2 percent
Alcohol propellant: 17.4 percent
1, 2-propylene glycol: 0.7 percent
2-methyl-2, 4-pentanediol: 0.8 percent
Glycerol: 0 percent of
Dimethyl sulfoxide: 0.1 percent of
Essence and spice: 0.5 percent
Example 7
Didecyl dimethyl ammonium chloride: 0.15 percent
Didecyl dimethyl ammonium chloride: 0.15 percent
1,1,1, 2-tetrafluoroethane: 80.2 percent
Alcohol propellant: 17.4 percent
1, 2-propylene glycol: 0.7 percent
2-methyl-2, 4-pentanediol: 0.8 percent
Glycerol: 0 percent of
Dimethyl sulfoxide: 0.1 percent of
Essence and spice: 0.5 percent
Performance testing
To verify the performance of the disinfectants described above in examples 1-7, various tests were conducted in accordance with the present invention. And evaluating according to WS/T650-2019 'evaluation method of antibacterial and bacteriostatic effects'.
And (4) checking and concluding:
index for killing microbe
1. After 3 repeated tests, the residual action of the disinfectant in examples 1-7 on escherichia coli can be effectively neutralized by using the PBS neutralizing agent containing 3% of histidine, 5% of tween-80 and 0.5% of lecithin under the condition of a constant temperature test at 20 ℃, and the neutralizing agent and a neutralized product thereof have no adverse effect on a culture medium and basically no effect on the growth of escherichia coli.
2. After 3 repeated tests, the samples treated by the disinfectant in the examples 1-7 are stored at room temperature for 7 days under the condition of constant temperature test at 20 ℃, and then are acted for 7.5min, 15.0min and 22.5min, the sterilization rate of escherichia coli is more than 90%, the long-acting antibacterial rule of WS/T650-2019 'evaluation method for antibacterial and bacteriostatic effects' is met, and the continuous antibacterial effect is achieved within 7 days.
II, toxicology index
The KM small acute oral toxicity test of the disinfectants in examples 1-7 proves that LDs0 is more than 5000mg/kg of body weight, and the toxicity classification is actually nontoxic. Meets the qualified requirement of disinfection technical specification (2002 edition).
Test equipment
1. Test strains: e.coli (8099), passage 6.
2. The disinfectant of examples 1-7.
3. Neutralizer components and concentrations: PBS containing 3% histidine, 5% tween-80 and 0.5% lecithin.
4. Diluting liquid: phosphate buffered saline (PBS, 0.03M, pH7.2).
5. Test carrier: defatted white plastic plate (50mmx50 mm).
6. Ordinary nutrient agar medium (A).
7. Biosafety cabinets, incubators, thermostats, vortex shakers, sterile equipment, electronic timers, and the like.
Method
1. The detection basis is as follows: WS/T650-2019 evaluation method of antibacterial and bacteriostatic effects 5.21.4 and 5.2.7.
2. And (3) identification test of a neutralizer: the disinfectant of examples 1-7 was used for the test, the duration of action was 10.0min, the test temperature was 20 ℃ constant, and the test was repeated 3 times.
3. Sample treatment: respectively coating the disinfectants in the embodiments 1-7 on the surface of a cloth piece according to the smearing requirements, and drying at room temperature for later use to serve as sample pieces of an experimental group; the samples without any treatment (pressure steam sterilization) served as control samples: both sets of coupons were stored in the laboratory at room temperature.
4. And (3) long-acting antibacterial detection: after the two groups of sample wafers are stored for 7 days, the sample wafers of the experimental group and the sample wafers of the control group are taken out for testing. Staining the bacterial suspension on the sample plate of the experimental group, acting for 7.5min, 15.0min and 22.5min, adding into neutralizer, mixing, diluting and inoculating. Meanwhile, the control group sample is put into the diluent at the same time, and diluted and inoculated after being mixed uniformly. Taking the test same batch of diluent, neutralizer and culture medium as negative control group, and culturing in a constant temperature incubator at 37 deg.C for 48 h. The test was repeated 3 times and the sterilization rate was calculated.
5. Detecting the ambient temperature: 22.1-22.8 ℃, relative humidity: 45 to 48 percent.
Results
1. Identification test result of neutralizer
After 3 repeated tests, under the constant temperature test condition of 20 ℃, the identification results of the disinfectant and the neutralizer in the examples 1-7 are as follows: the average number of colonies grown in example 7 was 1.52X104cfu/mL, average number of colonies grown in example 6 was 1.67X104cfu/mL, example 5 average number of grown colonies 1.56X10 respectively4cfu/mL, example 4 average number of colonies grown 1.72X10 respectively4cfu/mL, average number of colonies grown in example 3 was 1.84X104cfu/mL, average number of colonies grown in example 2 was 1.70X104cfu/mL, the average number of colonies grown in example 1 was 1.93X104cfu/mL。
From the above, it is understood that the average number of colonies is small in examples 7 and 5, and when the same amount of didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium chloride is used in example 5, the final sterilizing power of the disinfectant is poor when the content of didecyl dimethyl ammonium chloride alone, or both is more or less than that of examples 1 to 4 and 6, and the synergistic effect is strongest only when the same amount of didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium chloride is used, and when the same amount of didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium chloride is used, the content of alcohol type propellant is large in comparison examples 7 and 5, and example 7 is not limited to the use of didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium chloride, and therefore, in the invention, when the didecyl dimethyl ammonium chloride and the didecyl dimethyl ammonium chloride are used in equal amount and the alcohol propellant content is higher, the sterilizing capability of the disinfectant is strongest.
2. Killing effect on Escherichia coli
After 3 repeated tests, the disinfectant + treated sample wafers in examples 1-7 are stored at room temperature for 7 days under the constant temperature test condition of 20 ℃, and then the samples act for 7.5min, 15.0min and 22.5min, the sterilization rate of the samples on escherichia coli is more than 90%, the samples meet the long-acting antibacterial regulation of WS/T650-2019 'evaluation method of antibacterial and bacteriostatic effects', and the samples have continuous antibacterial action within 7 days. In detail, examples 1 to 7 correspond to the following sterilization rates:
example 1: 90.3 percent
Example 2: 90.8 percent
Example 3: 90.4 percent
Example 4: 91.5 percent
Example 5: 92.3 percent
Example 6: 91.3 percent
Example 7: 92.6 percent
From the above test data, it can be seen that the bactericidal rate is highest in examples 7 and 5, and lower in examples 1 to 4 and 6, and similarly, the same amount of didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium chloride is used in example 5, which proves that the synergistic effect is strongest only when the same amount of didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium chloride is used, and the alcohol propellant is more than the same amount of didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium chloride in example 7, comparing example 7 with example 5, so that the bactericidal ability of the disinfectant is strongest when the same amount of didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium chloride is used and the alcohol propellant is higher.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (8)
1. A broad spectrum disinfectant, comprising the following components:
quaternary ammonium salt disinfectant component: 0.2 to 0.4 percent
1,1,1, 2-tetrafluoroethane: 80 to 81 percent
Alcohol propellant: 16-18 percent
Alcohol antifreezing agent: 1.4 to 2.8 percent
Dimethyl sulfoxide: 0.1 to 0.2 percent
Essence and spice: 0.4 to 0.8 percent
The quaternary ammonium salt disinfectant comprises didecyl dimethyl ammonium chloride and didecyl dimethyl ammonium chloride.
2. The broad spectrum disinfectant of claim 1 wherein said alcohol propellant is isopropyl alcohol.
3. The wide spectrum disinfectant as set forth in claim 1, wherein said alcohol freezing point depressant is comprised of:
1, 2-propylene glycol: 0.5-1.0%
2-methyl-2, 4-pentanediol: 0.5-1.0%
Glycerol: 0.4 to 0.8 percent.
4. The wide spectrum disinfectant of claim 2 wherein said flavor and fragrance include one or more of eucalyptol, glycol phenyl ether, cinnamaldehyde, diphenyl ether.
5. The broad spectrum disinfectant of claim 1 wherein said broad spectrum disinfectant is adapted for H1N1 virus and lipophilic viruses such as ebola, coronavirus, influenza, hepatitis, hiv, staphylococcus aureus, enterococcus, pseudomonas aeruginosa, escherichia coli, aspergillus niger, candida albicans, mycobacterium avium, mycobacterium tuberculosis.
6. The wide spectrum disinfectant according to any one of claims 1 to 5, wherein the disinfectant is produced by a process comprising:
the disinfectant is prepared by mixing and dissolving the components except 1,1,1, 2-tetrafluoroethane and alcohol propellant, filling the mixture into a reaction container at room temperature, installing and fastening a valve of the reaction container, and pressing the 1,1,1, 2-tetrafluoroethane and alcohol propellant into the reaction container by a press-fitting machine.
7. The wide spectrum disinfectant according to any one of claims 1 to 5, wherein the disinfectant is produced by a process comprising:
the disinfectant is characterized in that except 1,1,1, 2-tetrafluoroethane and an alcohol propellant, other components are mixed and dissolved to form a mixed solution, the mixed solution is cooled to the temperature of-18 to-22 ℃ by a cooling device, meanwhile, the 1,1,1, 2-tetrafluoroethane and the alcohol propellant are also cooled to the temperature of-18 to-22 ℃ by the cooling device, then the cooled mixed solution, the cooled 1,1,1, 2-tetrafluoroethane and the alcohol propellant are sequentially filled into a reaction container, or the cooled mixed solution, the cooled 1,1,1, 2-tetrafluoroethane and the alcohol propellant are filled into the reaction container, and a valve of the reaction container is immediately installed and fastened within 3-5 s.
8. The use of the broad spectrum disinfectant as claimed in any one of claims 1 to 5, wherein the said disinfectant is prepared as a liquid and stored in a bottle with a valve, the bottle is placed in the place to be disinfected and the valve is released by pressing and rotating, the bottle generates a cloud of disinfection in 1-3 minutes, it is ensured that the place to be disinfected is sealed for more than 1 hour after the person is nobody in the place to be disinfected, and then the place to be disinfected is ventilated.
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