CN112244017A - Composite quaternary ammonium salt antibacterial spray - Google Patents
Composite quaternary ammonium salt antibacterial spray Download PDFInfo
- Publication number
- CN112244017A CN112244017A CN202010963914.3A CN202010963914A CN112244017A CN 112244017 A CN112244017 A CN 112244017A CN 202010963914 A CN202010963914 A CN 202010963914A CN 112244017 A CN112244017 A CN 112244017A
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- CN
- China
- Prior art keywords
- quaternary ammonium
- ammonium salt
- antibacterial spray
- antibacterial
- salt antibacterial
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
Abstract
A compound quaternary ammonium salt antibacterial spray belongs to the technical field of disinfectant. According to the mass fraction: 0.01-20 wt.% of quaternary ammonium salt, 0.01-20 wt.% of synergist, 0.1-20 wt.% of cosolvent, 0.01-5 wt.% of essence and the balance of water. The main effective component of the invention is quaternary ammonium salt, which has the advantages of high sterilization efficiency, stability, durability, small irritation and economy, can effectively inhibit the breeding and propagation of bacteria, and can be widely used in places such as families, markets, schools and the like.
Description
Technical Field
The invention relates to a compound quaternary ammonium salt antibacterial spray, belonging to the technical field of antibacterial agents.
Background
Antibacterial agents are generally classified into natural antibacterial agents, inorganic antibacterial agents and organic antibacterial agents. The natural antibacterial agent is mainly extracted from natural plants, such as chitin, mustard, castor oil, horseradish and the like, is simple and convenient to use, but has limited antibacterial action, poor heat resistance, low sterilization rate, no broad-spectrum long-acting use and small quantity; the inorganic antibacterial agent is prepared by fixing metals (or ions thereof) such as silver, copper and zinc on the surface of porous materials such as fluorite and silica gel by physical adsorption ion exchange method. Although the antibacterial agent has good thermal stability and safety, the antibacterial agent needs external conditions to excite the antibacterial property and is expensive; organic antibacterial agents such as quaternary ammonium salts, guanidine salts, quaternary phosphonium salts, etc., have long-lasting antibacterial effects and have been widely studied in recent years. Particularly, the quaternary ammonium salt compound has an amphiphilic structure, has obvious inhibition and killing effects on bacteria with strong pathogenicity, and can generate a good synergistic antibacterial effect through compound use.
The antibacterial property is an effective prevention and inhibition mechanism, and the safety of the antibacterial agent is ensured while the high-efficiency broad-spectrum antibacterial property is ensured. In the future, comprehensive antibacterial, bacteriostatic and antiviral products become a part of our daily life. Therefore, the invention has good antibacterial effect and durability, simple production process and low cost.
Disclosure of Invention
Aiming at the technical problems, the invention discloses a compound quaternary ammonium salt antibacterial spray which has the advantages of high sterilization efficiency, stability, durability, small irritation and economy.
The invention discloses a compound quaternary ammonium salt antibacterial spray, which comprises the following components in percentage by mass: 0.01-20 wt.% of quaternary ammonium salt, 0.01-20 wt.% of synergist, 0.1-20 wt.% of cosolvent, 0.01-5 wt.% of essence and the balance of water.
In some embodiments, in the compound quaternary ammonium salt antibacterial spray, the quaternary ammonium salt is one or more of benzalkonium chloride, benzalkonium bromide, didecyldimethylammonium chloride and didecyldimethylammonium bromide.
In some embodiments, the disinfectant further comprises 0.01 to 20 wt.% of a synergist.
In some embodiments, in the compound quaternary ammonium salt antibacterial spray, the synergist is one or more of propylene glycol, pentanediol, hexanediol, decanediol and p-hydroxyacetophenone.
In some embodiments, the disinfectant further comprises 0.1-10 wt.% of a cosolvent.
In some embodiments, in the compound quaternary ammonium salt antibacterial spray, the cosolvent is one or more of hydrogenated castor oil and essence cosolvent.
In some embodiments, the pH of the disinfectant in the compound quaternary ammonium salt antibacterial spray is 4.0-10.0.
Detailed Description
The performance test indexes in the examples of the method are those obtained by the conventional experimental methods in the field unless otherwise specified. It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure.
Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, and other non-specifically identified adjuvants and agents of the present invention refer to those conventionally used in the art.
The quaternary ammonium salt has the advantages of stable performance, small irritation, weak toxicity, low corrosivity, weak odor and the like. Meanwhile, the quaternary ammonium salt has good biodegradability and is environment-friendly, thus being a broad-spectrum disinfectant. Therefore, the quaternary ammonium salt can be widely applied to sterilization and disinfection in families, hospitals and public places.
The compound quaternary ammonium salt antibacterial spray disclosed by the invention has the advantages of high sterilization efficiency, stability, durability, small irritation and economy.
The invention is further illustrated by the following examples.
Example 1
Preferably, the compound quaternary ammonium salt antibacterial spray comprises the following components in parts by mass: didecyl dimethyl ammonium chloride 1.5 wt.%, pentylene glycol 0.5wt.%, hexylene glycol 0.1 wt.%, hydrogenated castor oil 2.0wt.%, fragrance 0.2 wt.%, and balance water.
Example 2
Preferably, the compound quaternary ammonium salt antibacterial spray comprises the following components in parts by mass: didecyl dimethyl ammonium bromide 2.0wt.%, propylene glycol 0.5wt.%, pentylene glycol 0.1 wt.%, hexylene glycol 0.1 wt.%, sebacic glycol 0.1 wt.%, hydrogenated castor oil 1.0 wt.%, flavor 0.3 wt.%, and balance water.
Example 3
Preferably, the compound quaternary ammonium salt antibacterial spray comprises the following components in parts by mass: didecyl dimethyl ammonium chloride 1.0 wt.%, benzalkonium chloride 0.5wt.%, propylene glycol 0.5wt.%, pentylene glycol 0.3 wt.%, hexylene glycol 0.1 wt.%, hexylene glycol 0.2 wt.%, hydrogenated castor oil 1.0 wt.%, flavor 0.15 wt.%, and balance water.
Example 4
Preferably, the compound quaternary ammonium salt antibacterial spray comprises the following components in parts by mass: didecyl dimethyl ammonium bromide 3.0 wt.%, benzalkonium bromide 0.4 wt.%, propylene glycol 0.2 wt.%, hexylene glycol 0.2 wt.%, sebacic glycol 0.1 wt.%, p-hydroxyacetophenone 1.0 wt.%, hydrogenated castor oil 2.0wt.%, perfume 0.1 wt.%, balance water.
Example 5
Preferably, the compound quaternary ammonium salt antibacterial spray comprises the following components in parts by mass: benzalkonium bromide 5.0 wt.%, propylene glycol 1.5 wt.%, p-hydroxyacetophenone 0.5wt.%, hydrogenated castor oil 2.5 wt.%, essence 0.15 wt.%, and water in balance.
The preparation method comprises the following steps: dissolving the synergist in water, stirring until the synergist is completely dissolved, adding the quaternary ammonium salt, and stirring for dissolving to obtain a solution A; mixing the cosolvent and the essence, standing for clarity and transparency to obtain solution B, mixing the solution A and the solution B, and stirring to obtain the final product.
Performance testing of examples 1 to 5.
1. Physical and chemical properties.
The compound quaternary ammonium salt antibacterial spray of the examples 1 to 5 has an average pH value of 6.12, basically has no corrosion to stainless steel, and slightly corrodes aluminum and carbon steel.
2. And a bacteria neutralizer identification test and a bacteria quantitative killing test.
The results of 3 times of repeated tests by adopting a bacteria neutralizer identification test and a bacteria quantitative killing test show that the D/E broth can neutralize the sterilization components in the antibacterial spray, and the neutralizer is suitable for the test of killing escherichia coli, staphylococcus aureus and pseudomonas aeruginosa by the test sample.
After 3 times of repeated tests, the average value of the sterilization rate of the antibacterial spray to escherichia coli in the suspension is 99.6%.
After 3 times of repeated tests, the average sterilization rate of the antibacterial spray to staphylococcus aureus in suspension is 99.7%.
After 3 times of repeated tests, the average sterilization rate of the antibacterial spray to the pseudomonas aeruginosa in the suspension is 99.9%.
Tests show that the antibacterial spray has the sterilization rate of more than 90% on escherichia coli, staphylococcus aureus and pseudomonas aeruginosa in suspension, and has the sterilization effect on the escherichia coli, the staphylococcus aureus and the pseudomonas aeruginosa.
3. Identification test of fungus neutralizer and killing test of fungus.
The results of 3 times of repeated tests by adopting a fungus neutralizer identification test and a fungus killing test on the compound quaternary ammonium salt antibacterial spray described in the examples 1 to 5 show that the D/E broth can neutralize the antibacterial components in the compound quaternary ammonium salt antibacterial spray, and the neutralizer is suitable for the test sample for killing candida albicans.
After 3 repeated tests, the average sterilization rate of the antibacterial spray on white streptococcus in suspension is 95.2%.
Tests show that the antibacterial spray has a sterilization rate of more than 90% on Candida albicans in suspension, and has a sterilization effect on Streptococcus albicans.
4. And (5) stability test.
And (3) appearance stability test: the antibacterial sprays described in examples 1 to 5 were respectively placed in a closed container, placed in a thermostat at 37 ℃ to 40 ℃ for 3 months, and the state was observed while maintaining a relative humidity of not less than 75%. The disinfectant solutions of examples 1 to 5 showed no change in color, were uniform, clear and transparent, and showed no precipitation or suspended matter, and had good appearance stability.
Chemical assay stability test: the antibacterial spray agents corresponding to the embodiments 1 to 5 are respectively arranged in a closed container and are placed in a constant temperature box with the temperature of 37 ℃ to 40 ℃ for 3 months, and the relative humidity is kept to be more than or equal to 75 percent. The content of the effective sterilization components of the disinfectant is respectively measured before and after the disinfectant is placed. The determination shows that the reduction rate of the effective components is 5.7 percent and is less than or equal to 10 percent, the requirement is met, and the storage period can be determined to be 2 years.
5. And (5) toxicological experiments.
Acute oral toxicity test (mice): the samples of the antibacterial spray corresponding to the examples 1 to 5 have acute oral LD50 values of more than 5000mg/kg b.wt. for female and male mice, and are practically nontoxic.
Primary integrity skin irritation test: the highest integral average value of the irritation response of the antibacterial spray samples corresponding to the examples 1 to 5 to the once intact skin of the rabbits is 0, and the irritation strength is nonirritant.
Multiple integrity skin irritation test: the average of the integral responses of the antibacterial spray samples corresponding to examples 1 to 5 to the rabbit skin irritation repeatedly is 0, and the irritation strength is nonirritant.
Mouse marrow pleochromocyte micronucleus test: the test dose of the antibacterial spray samples corresponding to the examples 1 to 5 reaches 5000mg/kg b.wt. the mouse bone marrow pleochromocyte has no micronucleus effect.
The compound quaternary ammonium salt antibacterial spray disclosed by the embodiment of the invention has the advantages of high sterilization efficiency, stability, durability, small irritation and economy.
The examples described are only a part of the present patent, and the embodiments based on the present patent are only exemplary, and it is apparent to those skilled in the art that various modifications and variations can be made to the embodiments of the present specification without departing from the scope or spirit of the present invention, resulting in other embodiments; all other embodiments obtained without inventive step are within the scope of the present patent protection.
Claims (5)
1. The compound quaternary ammonium salt antibacterial spray is characterized by being prepared by compounding multiple safe components: 0.01-20 wt.% of quaternary ammonium salt, 0.01-20 wt.% of synergist, 0.1-20 wt.% of cosolvent, 0.01-5 wt.% of essence and the balance of water.
2. The compound quaternary ammonium salt antibacterial spray according to claim 1, wherein the quaternary ammonium salt is one or more of benzalkonium chloride, benzalkonium bromide, didecyldimethylammonium chloride and didecyldimethylammonium bromide.
3. The compound quaternary ammonium salt antibacterial spray according to claim 1, wherein the synergist is one or more of propylene glycol, pentanediol, hexanediol, decanediol, and p-hydroxyacetophenone.
4. The compound quaternary ammonium salt antibacterial spray according to claim 1, wherein the cosolvent is one or more of hydrogenated castor oil and essence cosolvent.
5. The compound quaternary ammonium salt antibacterial spray according to claim 1, wherein the disinfectant has a pH value of 4.0-10.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010963914.3A CN112244017A (en) | 2020-09-15 | 2020-09-15 | Composite quaternary ammonium salt antibacterial spray |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010963914.3A CN112244017A (en) | 2020-09-15 | 2020-09-15 | Composite quaternary ammonium salt antibacterial spray |
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| Publication Number | Publication Date |
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| CN112244017A true CN112244017A (en) | 2021-01-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202010963914.3A Pending CN112244017A (en) | 2020-09-15 | 2020-09-15 | Composite quaternary ammonium salt antibacterial spray |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114514926A (en) * | 2022-01-19 | 2022-05-20 | 河北德阳生物科技有限公司 | Broad-spectrum disinfectant |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102077828A (en) * | 2009-11-27 | 2011-06-01 | 天津瑞普生物技术股份有限公司 | Compound disinfectant containing quaternary ammonium salt |
| CN109316536A (en) * | 2018-10-22 | 2019-02-12 | 湖南中威制药有限公司 | A kind of skin mucosa disinfecting agent and preparation method thereof |
-
2020
- 2020-09-15 CN CN202010963914.3A patent/CN112244017A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102077828A (en) * | 2009-11-27 | 2011-06-01 | 天津瑞普生物技术股份有限公司 | Compound disinfectant containing quaternary ammonium salt |
| CN109316536A (en) * | 2018-10-22 | 2019-02-12 | 湖南中威制药有限公司 | A kind of skin mucosa disinfecting agent and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114514926A (en) * | 2022-01-19 | 2022-05-20 | 河北德阳生物科技有限公司 | Broad-spectrum disinfectant |
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