CN106857685A - A kind of composition of disinfectant and preparation method thereof - Google Patents
A kind of composition of disinfectant and preparation method thereof Download PDFInfo
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- CN106857685A CN106857685A CN201611261056.8A CN201611261056A CN106857685A CN 106857685 A CN106857685 A CN 106857685A CN 201611261056 A CN201611261056 A CN 201611261056A CN 106857685 A CN106857685 A CN 106857685A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/04—Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/06—Coniferophyta [gymnosperms], e.g. cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/01—Deodorant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
- A61L2209/20—Method-related aspects
- A61L2209/21—Use of chemical compounds for treating air or the like
Abstract
The present invention relates to a kind of composition of disinfectant and preparation method thereof, disinfectant is made up of following composition and its components by weight percent：Constitute is 2 15 parts of aldehydes, 0.6 1 parts of biguanides, 0.01 0.1 parts of Cyclohexyl Methyl Dimethoxysilane, 0.01 0.1 parts of dimethyl diallyl ammonium chloride, 0 15 parts of quaternary ammonium salt, 80 100 parts of carrier.Disinfectant of the present invention has the advantages that efficient, non-stimulated, corrosivity is small, for the sterilization of poultry environment sterilization, equipment disinfection etc., there is wide market prospects and value.
Description
Technical field
The present invention relates to a kind of disinfectant and preparation method thereof, relate more specifically to one kind and disappear suitable for livestock and poultry cultivation place
Antiseptic composition of poison and preparation method thereof.
Background technology
With the development of modern intensive aquaculture, closed, highly dense type rearing conditions make livestock and poultry be subject to cause a disease
The threat of microorganism is increasingly severe, although putting into substantial amounts of funds on vaccine and medicine, cannot still avoid disease pair
The harm of animal body, also threatens the health of the mankind while these diseases are present.Cause the most basic factor of Animal diseases just
It is pathogenic microorganism, especially containing substantial amounts of pathogenic microorganism, parasitic ovum and the mosquitos and flies for multiplying in feces of livestock and poultry, these
Will increase cause of disease species in environment, amount of bacteria increases, and causes spreading for people, animal infectious disease, especially zoonosis, give
The harm of bringing on a disaster property of people and animals.
Disinfectant, is colourless liquid, there is intense irritation smell.For killing pathogenic microorganism on communication media, make it
Innoxious requirement is reached, pathogenic microorganism is eliminated outside human body, cut off the route of transmission of infectious disease, reach control infectious disease
Purpose.Various countries focus on to find environmental sound and act on quick disinfectant in recent years, wherein with hydrogen peroxide and titanium dioxide
Chlorine body sterilization more attracts attention, and the sterilization of ozone also has wide use value.Disinfectant can divide according to its level for acting on
It is bactericidal agent, high effect disinfectants, middle effect disinfectants, low effect disinfectants.But existing disinfectant excitant is big, poisonous or long-time
With having adverse side effect, with bactericidal effect but suppress that antibacterial effect is not obvious, bacterial reproduction is rapid.
The content of the invention
In view of this, it is small it is an object of the invention to provide a kind of nontoxic, corrosion-free, excitant and bactericidal effect is good, have
Effect suppresses bacterial reproduction, the wide disinfectant of bactericidal range, to be applied to the sterilization in livestock and poultry cultivation place.
Technical scheme
A kind of liquid disinfectant, disinfectant is made up of following composition and its components by weight percent：Constitute is aldehydes 2-15 parts, biguanides
0.6-1 parts, Cyclohexyl Methyl Dimethoxysilane 0.01-0.1 parts, dimethyl diallyl ammonium chloride 0.01-0.1 parts, quaternary ammonium
Salt 0-15 parts, carrier 80-100 parts.
Preferably, the aldehydes that the present invention is mentioned is one kind or any two kinds in OPA, glutaraldehyde, glyoxal
Mixture.
Preferably, the quaternary ammonium salt that the present invention is mentioned is dodecyl benzyl dimethyl ammonium chloride, myristalkonium
Ammonium chloride, cetalkonium chloride, stearyl dimethyl benzyl ammonium chloride, trimethyl chlorination
Ammonium, tetradecyl trimethyl ammonium chloride, hexadecyltrimethylammonium chloride, OTAC, dodecyl three
It is methyl bromide ammonium, TTAB, cetyl trimethylammonium bromide, Cetyltrimethylammonium bromide, double
Eight alkyl dimethyl ammonium chlorides, didecyl Dimethy ammonium chloride, double dodecyl dimethyl ammonium chlorides, double dodecyldimethylamines
Ammonium chloride, Varisoft 432PPG, dioctadecyl dimethyl ammonium chloride, double eight alkyl dimethyls ammonium bromides,
Didecyl Dimethy ammonium bromide, didodecyldimethylammbromide bromide, double dodecyldimethylamine base ammonium bromides, double hexadecyl
One or more mixed in ditallowdimethyl ammonium bromide, DDA, the double dimethyl quaternary ammoniums of chlorination
Compound.
Preferably, the biguanides mentioned of the present invention is one or two mixed in chlorhexidine acetate, polyhexamethylene guanide
Compound.
Preferably, the chelating agent that the present invention is mentioned is disodium ethylene diamine tetraacetate or ethylenediamine tetra-acetic acid.
Preferably, the corrosion inhibiter that the present invention is mentioned is the one kind in sodium metaphosphate, potassium metaphosphate or both mixing any
Thing.
Preferably, the present invention mentions application of the disinfectant in the sterilization in livestock and poultry cultivation place.
Preferably, the preparation method of the disinfectant that the present invention is mentioned is comprised the following steps：
1) purified water of full dose 40-70 volumes is taken, 2-15 parts of aldehydes is added, is stirred；
2) to step 1) middle addition 0-15 parts of quaternary ammonium salt and 0-3 parts of AEO, stir；
3) to step 2) middle addition 1-3 parts of turpentine oil, 1-3 parts of terpineol, 0.6-1 parts of biguanides, stir, adjusted with glacial acetic acid
PH to 3.0-7.0；
4) to step 3) in add 0.01-0.1 parts of chelating agent and 0.05-1 parts of corrosion inhibiter, purified water adds to full dose, stirs,
Filtration, it is filling, obtain final product.
Another object of the present invention is to the sterilization method that poultry of sterilizing, pouity dwelling place are sterilized, the sterilization method has been used and included
Use disinfectant recited above.
Be can be seen that from above, a technique effect of the invention, be that can reduce disinfectant to stainless by adding corrosion inhibiter
The corrosiveness of steel, carbon steel, aluminium, rubber etc..The corrosion inhibiter that the present invention is used is sodium metaphosphate, potassium metaphosphate or fatty alcohol polyoxy
One kind or both mixtures any in vinethene.Using the inventive method prepare the disinfectant containing corrosion inhibiter, its 1
: corrosion rate during 25 dilution factor to aluminium and carbon steel belongs to mild corrosion, and the corrosion rate to stainless steel belongs to no corrosion.
No corrosion is belonged to the corrosion rate of stainless steel, carbon steel, aluminium with the disinfectant of 1: 1000 dilution.Using this hair
The bright disinfectant containing corrosion inhibiter, will can extend the useful life of hardware common in animal house and facility.Secondly, the present invention
Inhibiter consumption is small, low cost, nontoxic, and have scale inhibition function.Compound method is simple, environmentally safe, to person poultry safety.
The disinfectant containing corrosion inhibiter prepared containing the inventive method is investigated in the embodiment of the present invention, it is keeping original antibacterial effect
On the premise of, also have the advantages that it is small, non-stimulated to mucous membrane to the excitant of animal, have no toxic side effect.
Another technique effect of the invention is that terpineol is added in disinfectant.Terpineol has certain fragrance,
Indoor bad smell can be removed as deodorizer, and add terpineol to play a part of wetting in disinfectant, hold disinfectant
Bacterium easily is attached to, so as to play a part of quick sterilization.Finally, terpineol is monocyclic monoterpene compounds, it is common for α-
Terpineol, is present in essential oil, be natural active antibacterial composition, its with aldehydes and quaternary ammonium salt as main active
Disinfectant for animals is combined, and can play the effect of enhancing bactericidal action.
Turpentine oil is added in disinfectant of the present invention, is that penetrability is strong, can make because turpentine oil has certain volatility
Aldehydes, biguanides and quaternary ammonium salt are easier to penetrate cell wall, to enter bacterial cell, nucleus are killed, so as to quickly kill bacterium
Deng germ.Terpineol and turpentine oil are with the addition of in disinfectant of the present invention, bactericidal effect is better than the effect of disinfectant is used alone.
Chelating agent is used in disinfectant of the present invention, it can reduce heavy metal in water with heavy metal ion chelating in water
The influence of ion pair disinfectant Disinfection Effect.
Aldehydes sterilizing power is strong in disinfectant of the present invention, has killing ability to bacterium, gemma, virus, mould etc., some aldehyde
Class has certain excitant, such as glutaraldehyde；Biguanides can kill Escherichia coli, staphylococcus aureus, to Pseudomonas aeruginosa, very
Bacterium is also effective；Quaternary ammonium salt has the advantages that bacteriocidal concentration is relatively low, stable in properties, good water solubility as cationic surfactant,
Bacterium can be effectively killed, but fungi, gemma, hydrophily virus can not be killed.It is generally acknowledged that quaternary ammonium salt, glutaraldehyde and double
Disinfection Effect is good in the basic conditions for the disinfectant of guanidine.Present invention finds in the mixing using above-mentioned three kinds of disinfectant components
Disinfectant pH sterilizes in 3.0-6.5, bactericidal effect is more preferable on the contrary.
The present invention by adding the auxiliary materials such as chelating agent, corrosion inhibiter, the disinfectant for animals prepared have it is efficient, non-stimulated,
The advantages of corrosivity is small.
Disinfectant for animals of the present invention is the aqueous solution, can be conveniently used for the sterilization of poultry environment sterilization, equipment disinfection etc..
Unit W/V is kg/L as nothing is particularly pointed out in the present invention.
To make the present invention easier to understand, with reference to specific embodiment, the present invention is expanded on further.It should be understood that this
A little embodiments are only illustrative of the invention and is not intended to limit the scope of the invention, NM specific experiment in the following example
Method, is generally carried out according to normal experiment method.
Specific embodiment
Embodiment 1：
Disinfectant of the present invention and preparation method thereof
5 parts of glutaraldehyde；
0.6 part of chlorhexidine acetate；
8 parts of dodecyl dimethyl benzyl ammonium bromide；
2 parts of AEO；
0.01 part of Cyclohexyl Methyl Dimethoxysilane；
0.01 part of dimethyl diallyl ammonium chloride；
2 parts of turpentine oil；
2 parts of terpineol；
0.01 part of disodium ethylene diamine tetraacetate；
1 part of sodium metaphosphate；
Purified water is to full dose；
Preparation process：
1) purified water 5L is taken, glutaraldehyde 500g is added, is stirred；2) to step 1) middle addition dodecyl dimethyl benzyl bromide a-bromotoluene
Change ammonium 800g, Cyclohexyl Methyl Dimethoxysilane 1g, dimethyl diallyl ammonium chloride 1g, AEO
200g, stirs, and Cyclohexyl Methyl Dimethoxysilane and dimethyl diallyl ammonium chloride have suppression bacterial reproduction
Effect, meanwhile, disinfectant is reduced to a certain extent stimulates big problem；3) to step 2) in add turpentine oil 200g, terpin
Alcohol 200g, chlorhexidine acetate 60g, are stirred, and pH=5.0 is adjusted with glacial acetic acid；4) to step 3) middle addition ethylenediamine tetra-acetic acid
Disodium 1g and sodium metaphosphate 100g, purified water adds to 10L, stirs, filtration, filling, obtains final product.
2. the disinfection effect test of disinfectant for animals of the present invention
1) test method
With reference to the Ministry of Agriculture《Disinfectant for animals qualification test technical specification》Method is tested, using bacterial suspension sizing technique.
2) test strain：Including Escherichia coli, staphylococcus aureus, bacillus cereus, Chinese veterinary medicament is purchased from
Supervision institute.
3) test procedure：
1. the bacterium solution of preparation is carried out into viable bacteria technology, be then diluted to containing bacterium 106~107 with the phosphate buffer of 0.03M/
The experiment bacterium solution of ml；
2. 0.5ml bacterium solutions are drawn in the disinfectant solution 4.5ml of test concentrations；
3. to put and act on 5min in 20 DEG C of water-baths；
4. above-mentioned bacterium medicine mixed liquor 1.0ml is drawn immediately, adds mixing in 9.0ml neutralizers；
5. thimerosal is replaced with 0.03M phosphate buffers, while carrying out above steps.As a control group；
6. count plate, calculating sterilizing rate are carried out after neutralizing 10min.
Disinfectant of the present invention is shown in Table 1,2 to the killing effect of different strains.
Sterilizing rate of the disinfectant of the present invention of table 1 to different strain
Sterilizing rate of the disinfectant of the present invention of table 2 to bacillus cereus
As it can be seen from table 1 when this disinfectant acts on Escherichia coli, in dilution factor for 1: 4800,2min is that can reach sterilization
It is required that, sterilizing rate, when dilution factor is 1: 6400, needs 10min to reach sterilization and requires more than 99.9, is 1: 9600 in dilution factor
When, sterilization is not reached within 10min and is required.When acting on staphylococcus aureus, in dilution factor for 1: 4800,5min is reachable
Required to sterilization, sterilizing rate, when dilution factor is 1: 6400, does not reach sterilization and require more than 99.9 within 10min.
From table 2 it can be seen that when this disinfectant acts on bacillus cereus, in dilution factor for 1: 25,30min is reachable
To the purpose for killing gemma of regulation, when dilution factor is 1: 50,60min reaches the purpose for killing gemma, is 1: 100 in dilution factor
When, 60min does not reach the purpose for killing gemma.
3. acute eye irritation test of the present invention
Experimental animal：Healthy rabbits 3,2.0~2.5kg of body weight；
Test method：Cancel the solution 0.1ml of 5 times of toxic agent highest application concentration, drip, opposite side intracapsular in rabbit side eye conjunctiva
Eye is using physiological saline as normal control.After drop tested material, eye is passively closed into 4s, with triumph normal saline washing after 30s.In eye drip
1h, 24h, 48h, 72h, 7d, 14d and 21d, visually observe damage and the recovery situation of rabbit eye conjunctiva, iris and cornea afterwards.Such as
Do not occur IR, or 7d or 14d in fruit 72h, eye irritation reaction recovers completely, you can termination test in advance.It is necessary
When, changed with 2 Fluresses, lens examination cornea and iris.By SSIC1/1 versions《Disinfection technology standard》In
2.3.4 the regulation of acute eye irritation test carries out Eye irritation scoring and stimulus intensity classification under item.
Result of the test：The average score of 3 animals 24h, 48h, 72h, tri- time points is：Corneal injury 0.7, iris 0.5,
Conjunctival congestion 1.4, (corneal injury ＜ 1, iris ＜ 1, conjunctival congestion ＜ 2, chemosis ＜ 2 belong to non-stimulated chemosis 1.1
Property), show that this disinfectant is nonirritant.
4. toxicity test of the present invention
Experimental animal：Healthy Kunming mouse 20, male and female half and half, 18~22g of body weight.
Trial drug：5000mg/kg body weight.
Test method：Mouse once oral gastric infusion, administered volume 20ml/kg bodies are given using disposable limitation administration by gavage
Weight, Continuous Observation 14d after administration records the poisoning manifestations and death condition of mouse.
Result of the test：Statistical analysis, carries out toxicity grading, as a result with reference to SSIC1/1 versions《Disinfection technology standard》In
2.3.1.6 regulation is evaluated under item, 3 are the results are shown in Table.
The disinfectant of the present invention of table 3 is to chmice acute Oral toxicity result of the test
| Sex | Dosage（mg/kg) | Number of elements（Only） | Dead number of elements（Only） | The death rate（%） | LD50（mg/kg) |
| It is male | 5000 | 10 | 0 | 0 | >5000 |
| It is female | 5000 | 10 | 0 | 0 | >5000 |
From table 3 it can be seen that this disinfectant is to male and female chmice acute Oral toxicity LD50 ＞ 5000mg/kg body weight, belong to actual
Nontoxic level.
5. the present invention is tested metal damage
Experiment metallic article：Stainless steel, carbon steel, aluminium.
Trial drug：1: 25 dilution, 1: 1000 dilution
Test method：With reference to the Ministry of Agriculture《Disinfectant for animals qualification test technical specification》And SSIC1/1 versions《Disinfection technology is advised
Model》Middle method is tested.
Result of the test：Be respectively to the corrosion rate of aluminium and carbon steel 0.031 when this disinfectant is 1: 25 dilution factor,
0.028mm/a (mm/a represents millimeter/year) belongs to mild corrosion (0.0100~＜ 0.1000mm/a), to the corrosion rate of stainless steel
For 0.0034mm/a belongs to no corrosion (＜ 0.0100mm/a).1: 1000 dilution disinfectant to stainless steel, carbon steel, aluminium corruption
Erosion speed is respectively 0.0014,0.0065,0.0068mm/a belong to no corrosion.
Embodiment 2
1. disinfectant of the present invention and preparation method thereof
2 parts of OPA
1 part of chlorhexidine acetate
15 parts of dodecyl benzyl dimethyl ammonium chloride
3 parts of AEO
2 parts of turpentine oil
2 parts of terpineol
0.05 part of ethylenediamine tetra-acetic acid
0.05 part of potassium metaphosphate
0.5 part of sodium metaphosphate
Purified water is to full dose
Preparation process：
1) purified water 4.5L is taken, OPA 200g is added, is stirred；
2) to step 1) middle addition dodecyl benzyl dimethyl ammonium chloride 1500g, AEO 300g, stirring is
It is even；
3) to step 2) in add turpentine oil 200g, terpineol 200g, chlorhexidine acetate 100g, stir, adjusted with glacial acetic acid
PH=5.5；
4) to step 3) in add ethylenediamine tetra-acetic acid 5g, potassium metaphosphate 5g, sodium metaphosphate 50g, purified water adds to 10L, stirs
Uniformly, filter, it is filling, obtain final product.
2. the disinfection effect test of disinfectant for animals of the present invention
Test method, test strain and gemma, test procedure are with embodiment 1.
Disinfectant for animals of the present invention is shown in Table 3,4 to the killing effect of different strains.
Sterilizing rate of the disinfectant of the present invention of table 4 to different strain
Sterilizing rate of the disinfectant of the present invention of table 5 to bacillus cereus
From table 4, it can be seen that when this disinfectant acts on Escherichia coli, in dilution factor for 1: 4800,2min is that can reach sterilization
It is required that, sterilizing rate, when dilution factor is 1: 6400, needs 10min to reach sterilization and requires more than 99.9, is 1: 9600 in dilution factor
When, sterilization is not reached within 10min and is required.When acting on staphylococcus aureus, in dilution factor for 1: 4800,5min is reachable
Required to sterilization, more than 99.9, when dilution factor is 1: 6400,10min can reach sterilization and requires sterilizing rate.
As can be seen from Table 5, when this disinfectant acts on bacillus cereus, in dilution factor for 1: 25,30min is reachable
To the purpose for killing gemma of regulation.When dilution factor is 1: 50, the purpose for killing gemma is not reached within 60min.
3. acute eye irritation test of the present invention
Experimental animal, test method are with the acute eye irritation test of embodiment 1.
Result of the test：The average score of 3 animals 24h, 48h, 72h, tri- time points is：Corneal injury 0.6, iris 0.6,
Conjunctival congestion 1.2, (corneal injury ＜ 1, iris ＜ 1, conjunctival congestion ＜ 2, chemosis ＜ 2 belong to non-stimulated chemosis 1.5
Property), show that this disinfectant is nonirritant.
4. toxicity test of the present invention
Experimental animal, test method are with the toxicity test of embodiment 1.
Result of the test：The disinfectant belongs to actual nothing to male and female chmice acute Oral toxicity LD50 ＞ 5000mg/kg body weight
Malicious level.
5. the present invention is tested metal damage
Experiment metallic article：Stainless steel, carbon steel, aluminium.
Trial drug：1: 25 dilution, 1: 1000 dilution
Test method：With reference to the Ministry of Agriculture《Disinfectant for animals qualification test technical specification》And SSIC1/1 versions《Disinfection technology is advised
Model》Middle method is tested.
Result of the test：Be respectively to the corrosion rate of aluminium and carbon steel 0.029 when this disinfectant is 1: 25 dilution factor,
0.027mm/a belongs to mild corrosion, and the corrosion rate to stainless steel is 0.0031mm/a category no corrosions.1: 1000 dilution disappear
Toxic agent to stainless steel, carbon steel, aluminium corrosion rate be respectively 0.0013,0.0064,0.0065mm/a belong to no corrosion.
Embodiment 3
1. disinfectant of the present invention and preparation method thereof
15 parts of glutaraldehyde
0.6 part of polyhexamethylene guanide
5 parts of double dodecyl dimethyl ammonium chlorides
1 part of AEO
3 parts of turpentine oil
3 parts of terpineol
0.01 part of disodium ethylene diamine tetraacetate
1 part of sodium metaphosphate
Purified water is to full dose
Preparation method
1) purified water 4L is taken, glutaraldehyde 1500g is added, is stirred；
2) to step 1) the middle double dodecyl dimethyl ammonium chloride 500g of addition, AEO 100g, stir
Uniformly；
3) to step 2) in add turpentine oil 300g, terpineol 300g, polyhexamethylene guanide 60g, stir, adjusted with glacial acetic acid
PH=4.5；
4) to step 3) in add disodium ethylene diamine tetraacetate 1g, sodium metaphosphate 100g, purified water to add to 10L, stir, filter
Cross, it is filling, obtain final product.
2. the disinfection effect test of disinfectant for animals of the present invention
Test method, test strain, test procedure are with embodiment 1.
Disinfectant for animals of the present invention is shown in Table 6,7 to the killing effect of different strains.
Sterilizing rate of the disinfectant of the present invention of table 6 to different strain
Sterilizing rate of the disinfectant of the present invention of table 7 to bacillus cereus
As can be seen from Table 6, it is that 1: 4800,1: 6400,5min can reach in dilution factor when this disinfectant acts on Escherichia coli
Sterilization requires that more than 99.9, when dilute at 1: 9600,10min does not reach sterilization and requires sterilizing rate.Act on golden yellow grape
It is that 1: 4800,1: 6400,10min can reach sterilization requirement in dilution factor during coccus, sterilizing rate is more than 99.9.
As can be seen from Table 7, when this disinfectant acts on bacillus cereus, in 1: 25 dilution, 30min is that can reach rule
The fixed purpose for killing gemma.When dilute at 1: 50, the purpose for killing gemma is not reached within 60min.
3. acute eye irritation test of the present invention
Experimental animal, test method are with the acute eye irritation test of embodiment 1.
Result of the test：The average score of 3 animals 24h, 48h, 72h, tri- time points is：Corneal injury 0.5, iris 0.6,
Conjunctival congestion 1.5, (corneal injury ＜ 1, iris ＜ 1, conjunctival congestion ＜ 2, chemosis ＜ 2 belong to non-stimulated chemosis 1.3
Property), show that this disinfectant is nonirritant.
4. toxicity test of the present invention
Experimental animal, test method are with the toxicity test of embodiment 1.
Result of the test：The disinfectant belongs to actual nothing to male and female chmice acute Oral toxicity LD50 ＞ 5000mg/kg body weight
Malicious level.
5. the present invention is tested metal damage
Experiment metallic article：Stainless steel, carbon steel, aluminium.
Trial drug：1: 25 dilution, 1: 1000 dilution
Test method：With reference to the Ministry of Agriculture《Disinfectant for animals qualification test technical specification》And SSIC1/1 versions《Disinfection technology is advised
Model》Middle method is tested.
Result of the test：Be respectively to the corrosion rate of aluminium and carbon steel 0.036 when this disinfectant is 1: 25 dilution factor,
0.033mm/a belongs to mild corrosion, and the corrosion rate to stainless steel is 0.0034mm/a category no corrosions.1: 1000 dilution disappear
Toxic agent to stainless steel, carbon steel, aluminium corrosion rate be respectively 0.0017,0.0067,0.0069mm/a belong to no corrosion.
Presently preferred embodiments of the present invention is the foregoing is only, is not intended to limit the invention, it is all in essence of the invention
Within god and principle, any modification, equivalent substitution and improvements made etc. should be included within the scope of the present invention.
Claims (8)
1. a kind of composition of disinfectant, it is characterised in that the disinfectant is made up of following composition and its components by weight percent：Composition
It is aldehydes 2-15 parts, biguanides 0.6-1 parts, Cyclohexyl Methyl Dimethoxysilane 0.01-0.1 parts, dimethyl diallyl chlorine
Change 0.01-0.1 parts, quaternary ammonium salt 0-15 parts, carrier 80-100 parts of ammonium.
2. the composition of disinfectant according to claim 1, it is characterised in that described aldehydes is OPA, penta
One kind or any two kinds of mixture in dialdehyde, glyoxal.
3. the composition of disinfectant according to claim 1, it is characterised in that described biguanides be acetic acid chlorhexidine,
One or two mixture in polyhexamethylene guanide.
4. the composition of disinfectant according to claim 1, it is characterised in that described quaternary ammonium salt is dimethyl
Base benzyl ammonium chloride, myristyl benzyl dimethyl ammonium chloride, cetalkonium chloride, octadecyldimethyl
Benzyl ammonium chloride, DTAC, tetradecyl trimethyl ammonium chloride, hexadecyltrimethylammonium chloride, ten
Eight alkyl trimethyl ammonium chlorides, DTAB, TTAB, cetyl trimethyl bromine
Change ammonium, Cetyltrimethylammonium bromide, double eight alkyl dimethyl ammonium chlorides, didecyl Dimethy ammonium chloride, double dodecanes
Base alkyl dimethyl ammonium chloride, double dodecyldimethylamine ammonium chlorides, Varisoft 432PPG, double octadecyldimethyls
Ammonium chloride, double eight alkyl dimethyls ammonium bromides, didecyl Dimethy ammonium bromide, didodecyldimethylammbromide bromide, double ten
One kind in tetraalkyl ditallowdimethyl ammonium bromide, DHAB, DDA or two
Plant the mixture of the above.
5. the composition of disinfectant according to claim 1, it is characterised in that described carrier is aliphatic alcohol polyethenoxy
Ether 0-3 parts, turpentine oil 1-3 parts, terpineol 1-3 parts, chelating agent 0.01-0.1 parts, corrosion inhibiter 0.05-1 parts, purified water to full dose.
6. the composition of disinfectant according to claim 5, it is characterised in that described chelating agent is ethylenediamine tetra-acetic acid
Disodium or ethylenediamine tetra-acetic acid.
7. the composition of disinfectant according to claim 5, it is characterised in that described corrosion inhibiter is sodium metaphosphate, partially
One kind or both mixtures any in potassium phosphate.
8. a kind of preparation method of the composition of the disinfectant as described in claim 1-7, it is characterised in that the preparation method bag
Include following steps：
1) purified water of full dose 40-70 volumes is taken, 2-15 parts of aldehydes is added, is stirred；
2) to step 1) middle addition 0-15 parts of quaternary ammonium salt and 0-3 parts of AEO, stir；
3) to step 2) middle addition 1-3 parts of turpentine oil, 1-3 parts of terpineol, 0.6-1 parts of biguanides, stir, adjusted with glacial acetic acid
PH to 4.5-6.0；
4) to step 3) in add 0.01-0.1 part chelating agent and 0.05-1 parts of corrosion inhibiter, purified water adds to full dose volume, stirring
Uniformly, filter, it is filling, obtain final product described disinfectant.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107258839A (en) * | 2017-07-12 | 2017-10-20 | 合肥华盖生物科技有限公司 | A kind of composite disinfectant and preparation method thereof |
| CN111466416A (en) * | 2020-04-20 | 2020-07-31 | 重庆森盟新能源开发有限公司 | Composite disinfectant using photocatalysis technology |
| CN111685115A (en) * | 2020-06-10 | 2020-09-22 | 勇昇元(北京)生物科技有限公司 | Compound quaternary ammonium salt disinfectant fluid containing traditional Chinese medicine extraction components |
| CN114868759A (en) * | 2022-07-11 | 2022-08-09 | 北京中科领德医药科技有限公司 | Long-acting quaternary ammonium salt disinfectant and preparation method thereof |
| RU2802317C1 (en) * | 2023-02-02 | 2023-08-24 | Федеральное государственное бюджетное научное учреждение "Федеральный научный центр - Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. К.И. Скрябина и Я.Р. Коваленко" (ФГБНУ ФНЦ ВИЭВ РАН) | Disinfestation agent against parasitic protozoa in young cattle |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107258839A (en) * | 2017-07-12 | 2017-10-20 | 合肥华盖生物科技有限公司 | A kind of composite disinfectant and preparation method thereof |
| CN111466416A (en) * | 2020-04-20 | 2020-07-31 | 重庆森盟新能源开发有限公司 | Composite disinfectant using photocatalysis technology |
| CN111685115A (en) * | 2020-06-10 | 2020-09-22 | 勇昇元(北京)生物科技有限公司 | Compound quaternary ammonium salt disinfectant fluid containing traditional Chinese medicine extraction components |
| CN114868759A (en) * | 2022-07-11 | 2022-08-09 | 北京中科领德医药科技有限公司 | Long-acting quaternary ammonium salt disinfectant and preparation method thereof |
| RU2802317C1 (en) * | 2023-02-02 | 2023-08-24 | Федеральное государственное бюджетное научное учреждение "Федеральный научный центр - Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. К.И. Скрябина и Я.Р. Коваленко" (ФГБНУ ФНЦ ВИЭВ РАН) | Disinfestation agent against parasitic protozoa in young cattle |
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