CN103719142B - A kind of disinfectant and preparation method thereof and application - Google Patents
A kind of disinfectant and preparation method thereof and application Download PDFInfo
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- CN103719142B CN103719142B CN201210382176.9A CN201210382176A CN103719142B CN 103719142 B CN103719142 B CN 103719142B CN 201210382176 A CN201210382176 A CN 201210382176A CN 103719142 B CN103719142 B CN 103719142B
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Abstract
The invention discloses a kind of disinfectant and preparation method thereof and application.This disinfectant comprises following B component and component A: B component: organic boronic and/or organic borate; Component A: quaternary ammonium salt cationic surfactant, wherein at least contain 10 carbon atoms in hydrophobic group, hydrophilic group is the cation of nitrogen atom.Disinfectant sterilizing ability provided by the present invention is strong, and germicidal efficiency can reach 99.9999%; This disinfectant to body surface and human body corrosivity, excitant and toxicity all little.Can to body surface and human body surface sterilization with this disinfectant, contact lenses and medical equipment are carried out disinfection, can prevent microorganism from being propagated between crowd by the contact of people and thing, the shortcoming that existing product is strong to human body excitant and bactericidal properties is low can be overcome, fill up the blank in market.
Description
Technical field
The present invention relates to a kind of disinfectant and preparation method thereof and application.
Background technology
Along with international community constantly globalizes, personnel exchange and are tending towards frequent, and the frequency that extensive popular virus occurs is also more and more higher, as SARS, and bird flu, swine flu etc.A kind of effective way of viral communication is prevented to be exactly the safe and convenient products efficiently killed body surface and comprise human skin germ of research and development.Oxidizing bactericide, as hydrogen peroxide, peracetic acid, hypochlorous acid, chlorine dioxide, chlorine etc., bactericidal action is very strong, but also has extremely strong corrosivity and the nocuity to human body.Reproducibility bactericide, as formaldehyde, acetaldehyde, glutaraldehyde, phthalic aldehyde etc. have intense stimulus to human body and toxicity.Quaternary ammonium salt, phenol and alcohol series bactericidal agent to human body excitant and toxicity less, but its bactericidal action is also very low, no matter is used alone or mixed use all can not kill many bacterial classifications.Therefore, need one effectively, disinfectant easily.
Summary of the invention
The object of this invention is to provide a kind of disinfectant.
Disinfectant provided by the present invention, comprises following component A and B component:
Component A: quaternary ammonium salt cationic surfactant, wherein at least contain 10 carbon atoms in hydrophobic group, hydrophilic group is the cation of nitrogen atom;
B component: the salt of compound shown in compound shown in formula I (i.e. organic boronic) and/or formula I:
Wherein, R is alkyl, alkylene, aryl radical or aryl radical derivative.
In above-mentioned disinfectant, described component A is at least one in following substances: Fixanol, alkyltrimethylammonium salt, alkyl-dimethyl ammonium salt, alkylammonium salt, benzyl chloride bismethane ammonium and chlorination puratized agricultural spray pine is peaceful;
Described Fixanol is specially 10 two to cetyl pyridinium salt, is more specifically cetylpyridinium chloride;
Described alkyltrimethylammonium salt is specially 10 two to cetrimonium salt, is more specifically DTAB;
Described alkyl-dimethyl ammonium salt is specially 10 two to etradecyldimethylamine ammonium salts;
Described alkylammonium salt is specially 10 two to cetyl ammonium salts.
The hydrophobic group of Fixanol is alkyl, and the hydrophobic group of alkyltrimethylammonium salt is alkyl, and the loose peaceful hydrophobic group of chlorination puratized agricultural spray is containing 14 carbon atoms.
Alkyl-dimethyl ammonium salt in described component A and alkylammonium salt can be transformed when pH<10 by corresponding alkyl dimethylamine and alkylamine.
In above-mentioned disinfectant, in described B component, described aryl radical is phenyl; Described aryl radical derivative is chlorphenyl, bromophenyl, nitrobenzophenone, aldehyde radical phenyl, aminophenyl or trifluoromethyl; Described alkyl is the alkyl that carbon atom number is less than 5;
Described nitrobenzophenone is specially m-nitro base, described aldehyde radical phenyl is specially PARA FORMALDEHYDE PRILLS(91,95) base phenyl.
In above-mentioned disinfectant, the mass percent concentration of described component A in described disinfectant is 0.00013%-0.22%, is specially 0.00013%, 0.02%, 0.03%, 0.04% or 0.22%;
In above-mentioned disinfectant, the mass percent concentration of described B component in described disinfectant is 0.05%-0.6%, is specially 0.05%, 0.08%, 0.1%, 0.15% or 0.6%.
In above-mentioned disinfectant, described disinfectant comprises component C: polar organic solvent;
The molecular weight of described polar organic solvent is preferably 30-1000Dra;
Described polar organic solvent be specially following a) or b) shown in material:
A) at least one in following substances: methyl alcohol, ethanol, propyl alcohol and isopropyl alcohol;
B) at least one in following substances: polyethylene glycol (being specially PEG400), propylene carbonate, ethylene glycol monomethyl ether, ethylene glycol list propyl ether, ethylene glycol monobutyl ether, glycerine furfural, Dimethyl isosorbide and polyoxyethylene fatty acid ester;
The mass percent concentration of described component C in described disinfectant is 0.2%-20%, is specially 0.2%, 6%, 8.2%, 16%, 17% or 20%.
In above-mentioned disinfectant, described disinfectant comprises component D: complexing of metal ion agent;
Described complexing of metal ion agent is specially EDTA or HEDTA; Commodity are called Versenol-120, Dow company of the U.S.; Usually each compound all has impurity metal ion to be mixed in its production process, the existence of metal ion can make the effect of killing gram-negative bacterium reduce, the effect of complexing of metal ion agent is complexation of metal ions impurity, and the bactericidal action of disinfectant is affected from it.
The mass percent concentration of described component D in described disinfectant is 0.01%-0.1%, is specially 0.01%, 0.02%, 0.05% or 0.1%.
In above-mentioned disinfectant, described disinfectant comprises component E: non-ionic surface active agent;
Described non-ionic surface active agent is specially the husky amine in pool Lip river and Families of poloxamers surfactant; The two is German BASF (BASF) Products.
The mass percent concentration of described component E in described disinfectant is 0.01%-0.1%, is specially 0.01%, 0.05% or 0.1%.
In above-mentioned disinfectant, described disinfectant comprises component F: at least one in citric acid, phosphoric acid, inorganic boric acid and triethanolamine;
The mass percent concentration of described component F in described disinfectant is 0.1%-0.3%, is specially 0.1%, 0.2% or 0.3%.
Also the additives such as spices or colouring agent can be comprised in above-mentioned disinfectant.Additives do not affect the bactericidal action of disinfectant usually, but can improve the appearance luster of disinfectant solution, smell etc.
In above-mentioned disinfectant, in described disinfectant, surplus is water.
The pH value of above-mentioned disinfectant can be 5-10, is specially 7-9, then is specially 7.8.
The osmotic pressure of described disinfectant is 270mOsm/kg.
Another object of the present invention is to provide a kind of method preparing above-mentioned disinfectant.
The method of the above-mentioned disinfectant of preparation provided by the present invention, comprises the steps: first B component to be mixed with water, dissolves, then adds other component, dissolves, adjust pH, then regulates osmotic pressure, add excess water, obtain described disinfectant.
Experiment prove, in preparation process, if first add phenyl boric acid and cetylpyridinium chloride, after add isopropyl alcohol, then phenyl boric acid and cetylpyridinium chloride first define precipitation, and this precipitation finally can be dissolved by isopropyl alcohol, but needs for a long time.In reality is produced in enormous quantities, the time needed for dissolution precipitation is longer, to such an extent as to cannot normally produce, and has a strong impact on production efficiency.
If cetylpyridinium chloride and phenyl boric acid form precipitation, then lose the ability destroying bacterial cell film, and then lose sterilization capability.
Above-mentioned arbitrary described disinfectant also belongs to protection scope of the present invention preparing the application in contact lens disinfecting solutions;
Above-mentioned arbitrary described disinfectant also belongs to protection scope of the present invention preparing the application in bactericide; Described bacterium is specially staphylococcus aureus (Staphylococcus aureus subsp.aureus), detection of Salmonella (Serratia marcescens), pseudomonas aeruginosa (Pseudomonas aeruginosa), Candida albicans (Candida albicans) or sickle-like bacteria (Fusarium solani).
Disinfectant sterilizing ability provided by the present invention is strong, and germicidal efficiency can reach 99.995%, and sterilization is fast; This disinfectant to body surface and human body corrosivity, excitant and toxicity all little.Can to body surface and human body surface sterilization with this disinfectant, medical equipment and contact lenses are carried out disinfection, can prevent microorganism from being propagated between crowd by the contact of people and thing, the shortcoming that existing product is strong to human body excitant and bactericidal properties is low can be overcome, fill up the blank in market.
Embodiment
The experimental technique used in following embodiment if no special instructions, is conventional method.
Material used in following embodiment, reagent etc., if no special instructions, all can obtain from commercial channels.
Phenyl boric acid purchased from American Aldrich company, catalog number is P20009; PARA FORMALDEHYDE PRILLS(91,95) base phenyl boric acid (4-Formylphenylboronic acid) purchased from American Aldrich company, catalog number is 431966; M-nitro boric acid purchased from American Aldrich company, catalog number is 325104; Cetylpyridinium chloride purchased from American Aldrich company, catalog number is 855820; Benzyl chloride bismethane ammonium (BenzalkoniumChloride) purchased from American Aldrich company, catalog number is 23442-7; Chlorination puratized agricultural spray pine peaceful (purchased from American Sigma company, catalog number is 53751; Dodecyltrimethylammonium bromide purchased from American Aldrich company, catalog number is 52367.The husky amine 904 in pool Lip river is purchased from German BASF (BASF) company, and poloxamer F127 is purchased from German BASF (BASF) company.PEG400 (polyethylene glycol, averagemolecular weight 400) purchased from American Aldrich company, catalog number is 202398.
Staphylococcus aureus (Staphylococcus aureus subsp.aureus Rosenbach) ATCC6538, purchased from American DSMZ (also known as American Type Culture Collection center, ATCC).
Detection of Salmonella (Serratia marcescens) ATCC 13880, pseudomonas aeruginosa (Pseudomonasaeruginosa) ATCC 15442, Candida albicans (Candida albicans) ATCC 10231 and sickle-like bacteria (Fusarium solani) ATCC 36031 is purchased from American DSMZ (also known as American Type Culture Collection center, ATCC) all.
Embodiment 1, the composition of disinfectant I, preparations and applicatio
One, composition and preparation
(1) form
(2) prepare
By each component according to mass fraction shown in (), prepare in the following order:
First phenyl boric acid and the mixing of part water, be heated to 60 DEG C, stirring and dissolving, obtain solution A.With another container, cetylpyridinium chloride is dissolved in part water, obtains solution B.
First in container, add isopropyl alcohol, add solution A, solution B, pool Lip river husky amine 904, EDTA and triethanolamine more wherein, mixed dissolution, regulates mixed solution acid-base value to pH=9 with sodium hydroxide and hydrochloric acid solution, add remaining water, obtain the disinfectant I shown in ().
(3) control group
Control group 1 solution: not containing phenyl boric acid and isopropyl alcohol, all the other components and mass fraction identical with disinfectant I, the weight of its vacancy replaces with the water of same weight.
Control group 2 solution: not containing cetylpyridinium chloride and isopropyl alcohol, all the other components and mass fraction identical with disinfectant I, the weight of its vacancy replaces with the water of same weight.
Two, effect detection
(1) sterilization detection method
Sterilization detects: disinfectant first filters through the sterilised membrane filter of 0.22 micron.Get 10 milliliters of filtered disinfectants in aseptic high density polyethylene pipe, separately get 10 milliliters of filtered physiological saline and compare in aseptic high density polyethylene pipe, in physiological saline, be also added with 0.05% Tween-80 and 0.1% buffer solution of sodium phosphate.Experimental temperature is 20-25 DEG C.
Cultivate staphylococcus ATCC 6538 with TSA agar medium, be added to by bacterium in the test tube containing physiological saline and bead and rotate dispersion 1 minute, obtain bacteria suspension, wherein bacteria concentration is 1x10
10cFU/ml.
Get 1ml bacteria suspension to 10 milliliter above-mentioned disinfectant and control sample respectively, sterilization, after 3 minutes, is got 0.1 milliliter containing bacterium sample, is added 9.9 milliliters of Letheen Broth neutralizers (French Becton Products), be designated as solution A.Add 9 milliliters of above-mentioned neutralizers with 1 ml soln A to rush rare 10 times (solution B), rush rare 10 times successively, obtain solution C, D and E.Get 1 milliliter of A, B, C, D, E solution, be added to the culture dish containing TSA agar medium.Staphylococcus in culture dish grows 3-5 days at 35 DEG C, and statistics survival clump count, calculates bactericidal effect by the clump count of surviving.
3 repetitions are established in experiment, and result is taken the mean.
Sterilization rate=(colony count for the colony count-survival of sterilization)/for colony count × 100% of sterilization.
(2) sterilization result
Disinfectant I: bacterium killing rate is 99.99995%, staphylococcus survival rate is 0.00005%;
Control group 1 solution: bacterium killing rate is 99.99928%, staphylococcus survival rate is 0.00072%;
Control group 2 solution: bactericidal effect is 0%.
(3) volatility of disinfectant detects
Volatility detects: be under the weather of 56% in humidity, spray skim disinfectant equably with spray bottle on a desktop, after about 8 minutes, the disinfectant on desktop volatilizees completely, and desktop is dry.Do same experiment with control group 1 and 2 solution not containing isopropyl alcohol, the control group solution on desktop did not wave bone dry in 40 minutes, showed that disinfectant of the present invention has good volatility.
Embodiment 2, the composition of disinfectant II, preparations and applicatio
One, form, prepare
(1) form
(2) prepare
According to component and mass fraction shown in (one), prepare according to order in embodiment 1.
(3) control group
Control group 1 solution: not containing PARA FORMALDEHYDE PRILLS(91,95) base phenyl boric acid and isopropyl alcohol, all the other components and mass fraction identical with disinfectant II, the weight of its vacancy replaces with the water of same weight.
Control group 2 solution: not containing benzyl chloride diformazan alkane ammonium and isopropyl alcohol, all the other components and mass fraction identical with disinfectant II, the weight of its vacancy replaces with the water of same weight.
Two, effect detection
(1) sterilization detection method
Sterilization detects: method is identical with described in embodiment 1, is 30 seconds unlike sterilizing time.
3 repetitions are established in experiment, and result is taken the mean.
Disinfectant II: staphylococcus killing rate is 99.9999%, staphylococcus survival rate is 0.0001%;
Control group 1 solution: bacterium killing rate is 99.9967%, staphylococcus survival rate is 0.0033%.
Control group 2 solution: bacterium killing rate is 0%.
(3) volatility of disinfectant detects
Volatility detects: be under the weather of 56% in humidity, spray skim disinfectant equably with spray bottle on a desktop, after about 8 minutes, the disinfectant on desktop volatilizees completely, and desktop is dry.Do same experiment with control group 1 and 2 solution not containing isopropyl alcohol, the control group solution on desktop did not wave bone dry in 40 minutes, showed that disinfectant of the present invention has good volatility.
Embodiment 3, the composition of disinfectant III, preparations and applicatio
One, form, prepare
(1) form
(2) prepare
According to component and mass fraction shown in (one), prepare according to order in embodiment 1, the pH value unlike disinfectant III is 8.5.
(3) control group
Control group 1 solution: not containing m-nitro boric acid and isopropyl alcohol, all the other components and mass fraction identical with disinfectant III, the weight of its vacancy replaces with the water of same weight.
Control group 2 solution: not containing dodecyltrimethylammonium bromide and isopropyl alcohol, all the other components and mass fraction identical with disinfectant III, the weight of its vacancy replaces with the water of same weight.
Two, effect detection
(1) sterilization detection method
Sterilization detects: method is identical with described in embodiment 1, is 1 minute unlike sterilizing time.
3 repetitions are established in experiment, and result is taken the mean.
Disinfectant of the present invention: bacterium killing rate is 99.9996%, staphylococcus survival rate is 0.0004%;
Control group 1 solution: killing rate is 99.9932%, staphylococcus survival rate is 0.0068%.
Control group 2 solution: bacterium killing rate is 0%.
(3) volatility of disinfectant detects
Volatility detects: be under the weather of 65% in humidity, spray skim disinfectant equably with spray bottle on a desktop, after about 8 minutes, the disinfectant on desktop volatilizees completely, and desktop is dry.Do same experiment with control group 1 and 2 solution not containing isopropyl alcohol, the control group solution on desktop did not wave bone dry in 1 hour, showed that disinfectant of the present invention has good volatility.
Embodiment 4, the composition of disinfectant IV, preparations and applicatio
One, form, prepare
(1) form
(2) prepare
According to component and mass fraction shown in (one), prepare according to order in embodiment 1, the pH value unlike disinfectant IV is 8.5.
(3) control group
Control group 1 solution: not containing phenyl boric acid and isopropyl alcohol, all the other components and mass fraction identical with disinfectant IV, the weight of its vacancy replaces with the water of same weight.
Control group 2 solution: containing chlorination puratized agricultural spray pine peace isopropyl alcohol, all the other components and mass fraction identical with disinfectant IV, the weight of its vacancy replaces with the water of same weight.
Two, effect detection
(1) sterilization detection method
Sterilization detects: method is identical with described in embodiment 1, is 2 minutes unlike sterilizing time.
3 repetitions are established in experiment, and result is taken the mean.
Disinfectant of the present invention: bacterium killing rate is 99.99989%, staphylococcus survival rate is 0.00011%;
Control group 1 solution: bacterium killing rate is 99.9965%, staphylococcus survival rate is 0.0035%.
Control group 2 solution: bacterium killing rate is 0%.
(3) volatility of disinfectant detects
Volatility detects: be under the weather of 56% in humidity, spray skim disinfectant equably with spray bottle on a desktop, after about 7 minutes, the disinfectant on desktop volatilizees completely, and desktop is dry.Do same experiment with control group 1 and 2 solution not containing isopropyl alcohol, the control group solution on desktop did not wave bone dry in 40 minutes, showed that disinfectant of the present invention has good volatility.
Embodiment 5, the composition of disinfectant V, preparations and applicatio
One, form, prepare
(1) form
(2) prepare
According to component and mass fraction shown in (one), prepare according to order in embodiment 1.
(3) control group
Control group 1 solution: not containing phenyl boric acid and isopropyl alcohol, all the other components and mass fraction identical with disinfectant V, the weight of its vacancy replaces with the water of same weight.
Control group 2 solution: not containing cetylpyridinium chloride and isopropyl alcohol, all the other components and mass fraction identical with disinfectant V, the weight of its vacancy replaces with the water of same weight.
Two, effect detection
(1) sterilization detection method
Sterilization detects: method is identical with described in embodiment 1, is 1 minute unlike sterilizing time.
3 repetitions are established in experiment, and result is taken the mean.
Disinfectant of the present invention: bacterium killing rate is 99.99999%, staphylococcus survival rate is 0.00001%;
Control group 1 solution: bacterium killing rate is 99.99986%, staphylococcus survival rate is 0.00014%.
Control group 2 solution: bacterium killing rate is 0%.
(3) volatility of disinfectant detects
Volatility detects: be under the weather of 56% in humidity, spray skim disinfectant equably with spray bottle on a desktop, after about 4 minutes, the disinfectant on desktop volatilizees completely, and desktop is dry.Do same experiment with control group 1 and 2 solution not containing isopropyl alcohol, the control group solution on desktop did not wave bone dry in 40 minutes, showed that disinfectant of the present invention has good volatility.
Embodiment 6, the composition of disinfectant VI, preparations and applicatio
One, composition and preparation
(1) form
The pH to 7.8 of solution is adjusted with sodium hydrate aqueous solution.
(2) prepare
By each component according to mass fraction shown in (), prepare in the following order:
First phenyl boric acid and the mixing of part water, be heated to 60 DEG C, stirring and dissolving, add cetylpyridinium chloride (because of cetylpyridinium chloride denier, precipitation can not be formed), poloxamer F127, EDTA, triethanolamine and PEG400 more successively, mixed dissolution, regulate mixed solution acid-base value to pH=7.8 with sodium hydroxide and hydrochloric acid solution, regulate the osmotic pressure of solution to 270mOsm/kg with sodium chloride, add remaining water, obtain the disinfectant VI shown in ().
(3) control group
Control group 1 solution: not containing phenyl boric acid, all the other components and mass fraction, pH value of solution and osmotic pressure identical with disinfectant VI, the weight of its vacancy replaces with the water of same weight.
Control group 2 solution: not containing cetylpyridinium chloride, all the other components and mass fraction identical with disinfectant VI, the weight of its vacancy replaces with the water of same weight.
Two, effect detection
(1) sterilization detection method
Sterilization detects: identical described in the detection method of detection of Salmonella (Serratia marcescens) ATCC 1388, gold-coloured staphylococci (Staphylococcus aureus) ATCC 65380 and pseudomonas aeruginosa (Pseudomonasaeruginosa) ATCC 15442 and embodiment 1.Replace TSA agar medium with SDA agar medium (French Becton Products) in Candida albicans (Candidaalbicans) ATCC 10231 and the detection of sickle-like bacteria (Fusarium solani) ATCC 36031, remaining method is identical with described in embodiment 1.Sterilizing time as different from Example 1 in this example is 6 hours.3 repetitions are established in experiment, and result is taken the mean.
(2) sterilization result
Disinfectant VI of the present invention: the killing rate of detection of Salmonella, gold-coloured staphylococci, pseudomonas aeruginosa, Candida albicans, sickle-like bacteria is respectively 99.951%, 99.9990%, 99.99983%, 99.9973% and 98.49%; Corresponding bacterium survival rate is respectively 0.049%, 0.001%, 0.00017%, 0.0027% and 1.5%.
Control group 1 solution: detection of Salmonella, gold-coloured staphylococci, pseudomonas aeruginosa, Candida albicans, be respectively 99.58%, 99.65%, 99.9988%, 99.92% and 84.86% with the killing rate of sickle-like bacteria; Corresponding bacterium survival rate is respectively 0.42%, 0.35%, 0.0012%, 0.081% and 15.1%.
Control group 2 solution: bactericidal effect is 0%.
Visible, weigh with the survival rate of bacterium, the sterilization intensity increase more than at least 10 times of disinfectant VI.
Claims (17)
1. a disinfectant, comprises following component A and B component:
Component A: quaternary ammonium salt cationic surfactant, wherein at least contain 10 carbon atoms in hydrophobic group, hydrophilic group is the cation of nitrogen atom;
B component: the salt of compound shown in compound shown in formula I and/or formula I:
Wherein, R is aryl radical or aryl radical derivative;
Described component A is at least one in following substances: Fixanol, alkyltrimethylammonium salt, alkyl-dimethyl ammonium salt, alkylammonium salt, benzyl chloride bismethane ammonium and chlorination puratized agricultural spray pine is peaceful;
In described B component, described aryl radical is phenyl; Described aryl radical derivative is chlorphenyl, bromophenyl, nitrobenzophenone, aldehyde radical phenyl, aminophenyl or trifluoromethyl; The mass percent concentration of described component A in described disinfectant is 0.00013%-0.22%;
The mass percent concentration of described B component in described disinfectant is 0.05%-0.6%;
Described disinfectant comprises component C: polar organic solvent;
The molecular weight of described polar organic solvent is 30-1000Dra;
Described polar organic solvent for following a) or b) shown in material:
A) at least one in following substances: methyl alcohol, ethanol, propyl alcohol and isopropyl alcohol;
B) at least one in following substances: polyethylene glycol, propylene carbonate, ethylene glycol monomethyl ether, ethylene glycol list propyl ether, ethylene glycol monobutyl ether, glycerine furfural, Dimethyl isosorbide and polyoxyethylene fatty acid ester; Described polyethylene glycol is PEG400;
The mass percent concentration of described component C in described disinfectant is 0.2%-20%.
2. disinfectant according to claim 1, is characterized in that:
Described Fixanol is 10 two to cetyl pyridinium salt;
Described alkyltrimethylammonium salt is 10 two to cetrimonium salt;
Described alkyl-dimethyl ammonium salt is 10 two to etradecyldimethylamine ammonium salts;
Described alkylammonium salt is 10 two to cetyl ammonium salts.
3. disinfectant according to claim 2, is characterized in that: described Fixanol is cetylpyridinium chloride;
Described alkyltrimethylammonium salt is DTAB.
4. disinfectant according to claim 1 and 2, is characterized in that: described nitrobenzophenone is m-nitro base.
5. disinfectant according to claim 4, is characterized in that: described aldehyde radical phenyl is PARA FORMALDEHYDE PRILLS(91,95) base phenyl.
6. disinfectant according to claim 1 and 2, is characterized in that: the mass percent concentration of described component A in described disinfectant is 0.00013%, 0.02%, 0.03%, 0.04% or 0.22%;
The mass percent concentration of described B component in described disinfectant is 0.05%, 0.08%, 0.1%, 0.15% or 0.6%.
7. disinfectant according to claim 1, is characterized in that: the mass percent concentration of described component C in described disinfectant is 0.2%, 6%, 8.2%, 16%, 17% or 20%.
8. disinfectant according to claim 1, is characterized in that: described disinfectant comprises component D: complexing of metal ion agent EDTA or HEDTA;
The mass percent concentration of described component D in described disinfectant is 0.01%-0.1%.
9. disinfectant according to claim 8, is characterized in that: the mass percent concentration of described component D in described disinfectant is 0.01%, 0.02%, 0.05% or 0.1%.
10. disinfectant according to claim 1, is characterized in that: described disinfectant comprises component E: the husky amine in non-ionic surface active agent pool Lip river and Families of poloxamers surfactant;
The mass percent concentration of described component E in described disinfectant is 0.01%-0.1%;
Described disinfectant comprises component F: at least one in citric acid, phosphoric acid, inorganic boric acid and triethanolamine; The mass percent concentration of described component F in described disinfectant is 0.1%-0.3%.
11. disinfectants according to claim 10, is characterized in that: the mass percent concentration of described component E in described disinfectant is 0.01%, 0.05% or 0.1%;
The mass percent concentration of described component F in described disinfectant is 0.1%, 0.2% or 0.3%.
12. disinfectants according to claim 1, is characterized in that: in described disinfectant, and surplus is water; The pH value of described disinfectant is 5-10; The osmotic pressure of described disinfectant is 270mOsm/kg.
13. disinfectants according to claim 12, is characterized in that: the pH value of described disinfectant is 7-9.
14. disinfectants according to claim 13, is characterized in that: the pH value of described disinfectant is 7.8.
The preparation method of disinfectant described in 15. claims 12, comprises the steps: first B component to be mixed with water, dissolves, then adds other component, dissolves, adjust pH, then regulates osmotic pressure, add excess water, obtain described disinfectant.
In 16. claim 1-15, the application in contact lens disinfecting solutions prepared by arbitrary described disinfectant;
In 17. claim 1-15, the application in bactericide prepared by arbitrary described disinfectant; Described bacterium is one or more in staphylococcus aureus (Staphylococcus aureus subsp.aureus), detection of Salmonella (Serratiamarcescens), pseudomonas aeruginosa (Pseudomonas aeruginosa), Candida albicans (Candidaalbicans) or sickle-like bacteria (Fusarium solani).
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| CN104872175B (en) * | 2015-04-29 | 2017-07-21 | 苏州市湘园特种精细化工有限公司 | A kind of bactericide and preparation method thereof |
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| US11253625B2 (en) | 2018-06-27 | 2022-02-22 | Bausch & Lomb Incorporated | Ophthalmic device packaging solutions comprising a poloxamine/erythritol mixture |
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