CN104434994A - Mucocutaneous disinfectant - Google Patents
Mucocutaneous disinfectant Download PDFInfo
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- CN104434994A CN104434994A CN201410700152.2A CN201410700152A CN104434994A CN 104434994 A CN104434994 A CN 104434994A CN 201410700152 A CN201410700152 A CN 201410700152A CN 104434994 A CN104434994 A CN 104434994A
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- disinfectant
- quaternary ammonium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Abstract
The invention provides a mucocutaneous disinfectant which comprises the following ingredients in parts by weight: 5-10 parts of chitosan quaternary ammonium salt, 3-5 parts of alkyl dimethyl benzyl ammonium chloride, 5-10 parts of sodium polyoxyethylene nonylphenyl ether sulphate, 5-10 parts of ethanol, 3-5 parts of beewax, 5-10 parts of povidone iodine, 3-5 parts of a surfactant, 1-3 parts of urea and 30-40 parts of deionized water. The mucocutaneous disinfectant provided by the invention has no pungent smell, has low toxicity and weak irritation to skin and eyes, is suitable for mucocutaneous disinfection and has no pollution to environment. Meanwhile, under the combined effect of the active ingredients of the disinfectant, the sterilization and disinfection effects are improved.
Description
Technical field
The present invention relates to disinfectant technical field, particularly a kind of skin mucosa disinfectant.
Background technology
Protecting human body gets up by skin and mucosa, and making human body define an airtight system to external world, when harmful substance will invade human body, is first that extraneous paathogenic factor is blocked in external by skin and mucosa.So skin and mucosa are human body anti-infective the first line of defences.Therefore the sterilization outbalance of skin mucosa.
At present, skin mucosa disinfectant preparation mainly contains: 1, peracetic acid, peracetic acid mainly relies on its Strong oxdiative ability to the killing action of microorganism, it can destroy the permeability barrier of bacterial spore, and then destroy and dissolve core, the material damage of DNA, RNA, protein is spilt, causes spore dead.Peracetic acid is usually used in by virus contamination article or skin degerming, and during general sterilisation of objects, usable concentration is 0.5%, and during skin degerming, usable concentration is 0.2%-0.4%, and action time is 3 minutes.But Organic substance can reduce the bactericidal action of peracetic acid, needed for the thin rice seedling brood body killing 20% serum protection, peroxyacetic acid concentration need increase by 4 ~ 15 times, and need increase by 2 ~ 3 times to bacterial spore.Peracetic acid soln is unstable, need be placed in ventilating and cooling place during storage, first measures valid density altogether with front; With distilled water, deionized water or pure water prepared and diluted liquid, preserve no more than 48h under diluent room temperature.Peracetic acid has very strong corrosivity to metal, acutely decomposes, even blast when having bases or Organic substance to be mixed into.The medicinal liquid of high concentration has severe corrosive and zest, and its abnormal smells from the patient people is beyond affordability.2, alcohol disinfectant: 1. ethanol belongs to middle effect disinfectants, bactericidal action is very fast, and non-stimulated to human body, toxicity is less.Ethanol sterilization there are certain requirements concentration, and its effective volume fraction should be 65% ~ 75%.Water to ethanol play bactericidal action very necessary, need dilute ethanol time therefore for sterilizing, but concentration lower than 30% time bactericidal action very little, concentration is crossed strong or excessively weak, and bactericidal action all can reduce.The folk prescription ethanol disinfection preparation of 75% to human non-toxic, but due to the body constitution of people different, one or two people are irritated to ethanol, can cause erythra, erythema after contact.Ethanol disinfection preparation often uses, skin therefore can produce defat and drying, the phenomenon such as coarse.2. isopropyl alcohol: the bactericidal action of isopropyl alcohol is better than ethanol.But it belongs to slight noxious substance, when exceeding finite concentration, there is intense stimulus effect to respiratory mucosa and eye conjunctiva, and cell tissue can be caused downright bad.Aqueous isopropanol is by force fat dissolving, repeatedly contacts skin and can make xerosis cutis defat.In addition, Organic substance and low temperature all can make the bactericidal effect of isopropyl alcohol weaken.3, iodine-containing disinfectant: common ground povidone iodine and iodine tincture.Their halogenation microproteins of relying make it dead.Can kill vegetative forms of bacteria, fungus and fractionated viral.May be used for skin, mucosa sterilization, hospital is usually used in surgical hand sterilization.The working concentration of general iodine tincture is 2%, and povidone iodine working concentration is 0.3% to 0.5%.But iodide ion is extremely active, its oxidizing force is very strong, is a kind of material of instability, can reduce effective content and reduce disinfective action.
One section of publication number is the preparation method disclosing a kind of composite type medical disinfectant in the patent document of CN1182533, it is by glutaraldehyde, Radix Glycyrrhizae derivant, non-ionic surface active agent, essence, deionized water forms, this disinfectant can be directly used in the washing of various trauma patient, sterilization, simultaneously to the sterilization of medical worker's operation consent, the sterilization of various medical apparatus and instruments, the sterilization of hygienic article all has function and the cleaning function of very strong killing pathogenic bacteria, simultaneously main is have promotion wound, the effect of healing, this disinfectant chemical stabilization, safety is high, without any side effects to human body skin.Glutaraldehyde is wherein the colourless transparent oil liquid with penetrating odor, is dissolved in hot water, has strong impulse effect to eyes, skin and mucosa, although bactericidal effect is good, is not suitable for the sterilization of skin and mucosa.
Summary of the invention
The object of the present invention is to provide a kind of skin mucosa disinfectant, this disinfectant liquid for skin comprehensively effectively sterilize, little to skin irritation, use rear skin moist, be applicable to the sterilization of skin mucosa.
For solving the problems of the technologies described above, the present invention is achieved through the following technical solutions.
A kind of disinfectant liquid for skin, comprise the following compositions of following weight parts, chitosan quaternary ammonium salt 5-10 part, zephiran 3-5 part, nonylphenol polyoxyethylene ether sulfate 5-10 part, ethanol 5-10 part, Cera Flava 3-5 part, povidone iodine 5-10 part, surfactant 3-5 part; Carbamide 1-3 part, deionized water 30-40 parts, described skin mucosa disinfectant pH is 7-9.
Described skin mucosa disinfectant comprises the following composition of following weight parts: chitosan quaternary ammonium salt 8 parts, alkyl dimethyl benzyl ammonium 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, 4 parts, Cera Flava, povidone iodine 8 parts, 3 parts, surfactant; 2 parts, carbamide, deionized water 35 parts.
Described chitosan quaternary ammonium salinity is 1.5mg/ml.
Described chitosan quaternary ammonium salt is N – N-propyl-N, N-dimethyl chitosan.
Described surfactant be CH3-(CH2)13N(CH3)2-O, octyl phenol polyoxyethylene, myristyl dimethyl amine oxide one or more.
Described skin mucosa disinfectant is prepared by following step:
(1) chitosan quaternary ammonium salt, zephiran, nonylphenol polyoxyethylene ether sulfate, ethanol, Cera Flava, surfactant is taken by above-mentioned formula; Carbamide, deionized water, for subsequent use;
(2) will take ethanol, nonylphenol polyoxyethylene ether sulfate and surfactant, Cera Flava add in container and stir in step (1), then add in step (1) and take the stirring of chitosan quaternary ammonium salt, zephiran, povidone iodine and carbamide makes it dissolve completely, the deionized water added in step (1) forms homogeneous liquid.
Described step (2) operates at 30-35 DEG C.
Described Cera Flava first melts before addition.
Beneficial effect:
1, the present invention adopts the composite sterilization component as this disinfectant liquid for skin of these four kinds of materials of chitosan quaternary ammonium salt, ethanol, zephiran, povidone iodine, can effectively kill each pathogenic bacteria, wherein each composition composite obtain skin irritation little, be particularly suitable for the sterilizing of skin mucosa, in addition, adopt chitosan quaternary ammonium salt and zephiran to share, there is synergism, the bactericidal action of chitosan quaternary ammonium salt can be improved; Nonylphenol polyoxyethylene ether sulfate has a certain amount of epoxy radicals and sulfate, therefore it has nonionic and anion surfactant double properties concurrently, clean clean effect is good, also very little to the zest of skin, skin can be made to moisten containing Cera Flava in the present invention moist, and Cera Flava has the circulation and activating cell that promote skin blood, and there is the effect of antiinflammatory, particularly to there being wound to have astriction; Carbamide in the present invention has the effect of stabilizing agent, share simultaneously, play the effect to skin moisture-keeping with Cera Flava.
So disinfectant of the present invention does not have penetrating odor, toxicity low, weak to the zest of skin mucosa and eyes, environmentally safe.Simultaneously due to the mating reaction of antimicrobial activity composition, improve disinfection effect, increase germicidal efficiency.
Detailed description of the invention
The present invention is further illustrated below by detailed description of the invention.
Embodiment 1
A kind of skin mucosa disinfectant, comprises the following compositions of following weight parts, chitosan quaternary ammonium salt 5 parts, zephiran 3 parts, nonylphenol polyoxyethylene ether sulfate 5 parts, ethanol 5 parts, 3 parts, Cera Flava, povidone iodine 5 parts, 3 parts, surfactant; 1 part, carbamide, deionized water 30, described skin mucosa disinfectant pH is 7-9.
Embodiment 2
A kind of skin mucosa disinfectant, comprises the following compositions of following weight parts, chitosan quaternary ammonium salt 6 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 6 parts, ethanol 6 parts, 4 parts, Cera Flava, povidone iodine 8 parts, 4 parts, surfactant; 2 parts, carbamide, deionized water 33 parts, described skin mucosa disinfectant pH is 7-9.Described chitosan quaternary ammonium salinity is 1.5mg/ml
Embodiment 3
A kind of skin mucosa disinfectant, comprise the following compositions of following weight parts, chitosan quaternary ammonium salt 10 parts, zephiran 5 parts, nonylphenol polyoxyethylene ether sulfate 10 parts, ethanol 10 parts, 5 parts, Cera Flava, povidone iodine 10 parts, 5 parts, surfactant; 3 parts, carbamide, deionization moisture content 40 parts, described skin mucosa disinfectant pH is 7-9.Described chitosan quaternary ammonium salt is N – N-propyl-N, N-dimethyl chitosan.
Embodiment 4
A kind of skin mucosa disinfectant, comprises the following compositions of following weight parts, chitosan quaternary ammonium salt 7 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 7 parts, ethanol 8 parts, 4 parts, Cera Flava, povidone iodine 8 parts, 5 parts, surfactant; 2 parts, carbamide, deionized water 35 parts, described skin mucosa disinfectant pH is 7-9.Described surfactant is myristyl dimethyl amine oxide.
Embodiment 5
A kind of skin mucosa disinfectant, comprises the following compositions of following weight parts, chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, ethanol 7 parts, 4 parts, Cera Flava, povidone iodine 8 parts, 4 parts, surfactant; 2 parts, carbamide, deionization moisture content 35 parts, described skin mucosa disinfectant pH is 7-9.Described surfactant is octyl phenol polyoxyethylene.
Embodiment 6
A kind of skin mucosa disinfectant, comprises the following compositions of following weight parts, chitosan quaternary ammonium salt 5 parts, zephiran 3 parts, nonylphenol polyoxyethylene ether sulfate 5 parts, ethanol 5 parts, 3 parts, Cera Flava, povidone iodine 5 parts, 3 parts, surfactant; 1 part, carbamide, deionized water 30, described skin mucosa disinfectant pH is 7-9.Described surfactant is CH3-(CH2)13N(CH3)2-O.
Embodiment 7
A kind of skin mucosa disinfectant, comprises the following compositions of following weight parts, chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, ethanol 9 parts, 4 parts, Cera Flava, povidone iodine 8 parts, 4 parts, surfactant; 2 parts, carbamide, deionization moisture content 38 parts, described skin mucosa disinfectant pH is 7-9.Described surfactant is CH3-(CH2)13N(CH3)2-O, octyl phenol polyoxyethylene.
Embodiment 8
A kind of skin mucosa disinfectant, comprises the following compositions of following weight parts, chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, ethanol 8 parts, 4 parts, Cera Flava, povidone iodine 8 parts, 4 parts, surfactant; 2 parts, carbamide, deionization moisture content 38 parts, described skin mucosa disinfectant pH is 7-9.Described surfactant is CH3-(CH2)13N(CH3)2-O, octyl phenol polyoxyethylene, myristyl dimethyl amine oxide.
Embodiment 9
A kind of skin mucosa disinfectant, comprises the following composition of following weight parts: chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, ethanol 9 parts, 4 parts, Cera Flava, povidone iodine 8 parts, 3 parts, surfactant; 2 parts, carbamide, deionized water 35 parts, described skin mucosa disinfectant pH is 7-9.Described disinfectant liquid for skin is prepared by following step:
(1) chitosan quaternary ammonium salt, zephiran, nonylphenol polyoxyethylene ether sulfate, ethanol, Cera Flava, povidone iodine, surfactant is taken by above-mentioned formula; Carbamide, deionized water are for subsequent use,
(2) will take ethanol, nonylphenol polyoxyethylene ether sulfate and surfactant, Cera Flava add in container and stir in step (1), then add in step (1) and take the stirring of chitosan quaternary ammonium salt, zephiran, povidone iodine and carbamide makes it dissolve completely, the deionized water added in step (1) forms homogeneous liquid.
Described step (2) operates at 30-35 DEG C.
Described Cera Flava first melts before addition.
Claims (8)
1. a skin mucosa disinfectant, it is characterized in that: the following compositions comprising following weight parts, chitosan quaternary ammonium salt 5-10 part, zephiran 3-5 part, nonylphenol polyoxyethylene ether sulfate 5-10 part, ethanol 5-10 part, Cera Flava 3-5 part, povidone iodine 5-10 part, surfactant 3-5 part; Carbamide 1-3 part, deionized water 30-40 part, described skin mucosa disinfectant pH is 7-9.
2. a kind of skin mucosa disinfectant according to claim 1: it is characterized in that: described disinfectant liquid for skin comprises the following composition of following weight parts: chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, ethanol 7 parts, 4 parts, Cera Flava, povidone iodine 8 parts, 4 parts, surfactant; 2 parts, carbamide, deionized water 25 parts.
3. a kind of skin mucosa disinfectant according to claim 1: it is characterized in that: described chitosan quaternary ammonium salinity is 1.5mg/ml.
4. a kind of skin mucosa disinfectant according to claim 3: it is characterized in that: described chitosan quaternary ammonium salt is N – N-propyl-N, N-dimethyl chitosan.
5. a kind of skin mucosa disinfectant according to claim 1 and 2: it is characterized in that: described surfactant be CH3-(CH2)13N(CH3)2-O, octyl phenol polyoxyethylene, myristyl dimethyl amine oxide one or more.
6. a kind of skin mucosa disinfectant according to claim 1: it is characterized in that: described disinfectant liquid for skin is prepared by following step:
(1) chitosan quaternary ammonium salt, zephiran, nonylphenol polyoxyethylene ether sulfate, ethanol, Cera Flava, myristic aldehyde, surfactant is taken by above-mentioned formula; Carbamide, deionized water are for subsequent use,
(2) will take ethanol, nonylphenol polyoxyethylene ether sulfate, surfactant, Cera Flava add in container and stir in step (1), then add in step (1) and take the stirring of chitosan quaternary ammonium salt, zephiran, povidone iodine and carbamide makes it dissolve completely, the deionized water added in step (1) forms homogeneous liquid.
7. a kind of skin mucosa disinfectant according to claim 6: it is characterized in that: described step (2) operates at 30-35 DEG C.
8. a kind of skin mucosa disinfectant according to claim 6: it is characterized in that: described Cera Flava first melts before addition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410700152.2A CN104434994A (en) | 2014-11-28 | 2014-11-28 | Mucocutaneous disinfectant |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410700152.2A CN104434994A (en) | 2014-11-28 | 2014-11-28 | Mucocutaneous disinfectant |
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| CN104434994A true CN104434994A (en) | 2015-03-25 |
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| CN201410700152.2A Pending CN104434994A (en) | 2014-11-28 | 2014-11-28 | Mucocutaneous disinfectant |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105557751A (en) * | 2015-05-18 | 2016-05-11 | 深圳市安多福动物药业有限公司 | Macromolecular bioorganic iodine, method for preparing same and method for preventing and treating aquaculture diseases |
| CN105560271A (en) * | 2016-03-04 | 2016-05-11 | 深圳市阳光百度生物科技发展有限公司 | Chitosan povidone-iodine solution and manufacturing technologythereof |
| CN107536828A (en) * | 2016-06-28 | 2018-01-05 | 上海国汇生物科技有限公司 | A kind of skin mucous membrane disinfectants |
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| CN1470167A (en) * | 2003-06-17 | 2004-01-28 | 中国海洋大学 | Preparatino method of low-molecular chitosar quaternary ammonium salt complex iodine clear venom |
| CN101491537A (en) * | 2008-01-24 | 2009-07-29 | 程斌 | Glacial acetic acid chitosan composite antibiotic liquid |
| CN101524366A (en) * | 2009-03-21 | 2009-09-09 | 刘维峰 | Method for preparing compound biological activity sterilizing fluid |
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2014
- 2014-11-28 CN CN201410700152.2A patent/CN104434994A/en active Pending
Patent Citations (4)
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| CN1470167A (en) * | 2003-06-17 | 2004-01-28 | 中国海洋大学 | Preparatino method of low-molecular chitosar quaternary ammonium salt complex iodine clear venom |
| CN101491537A (en) * | 2008-01-24 | 2009-07-29 | 程斌 | Glacial acetic acid chitosan composite antibiotic liquid |
| CN101524366A (en) * | 2009-03-21 | 2009-09-09 | 刘维峰 | Method for preparing compound biological activity sterilizing fluid |
| CN103720712A (en) * | 2012-10-10 | 2014-04-16 | 上海工程技术大学 | Method for preparing quaternized chitosan nano iodine disinfectant |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105557751A (en) * | 2015-05-18 | 2016-05-11 | 深圳市安多福动物药业有限公司 | Macromolecular bioorganic iodine, method for preparing same and method for preventing and treating aquaculture diseases |
| CN105557751B (en) * | 2015-05-18 | 2018-08-07 | 深圳市安多福动物药业有限公司 | High-molecular biologic organic iodine and preparation method thereof, aquaculture disease prevention and cure method |
| CN105560271A (en) * | 2016-03-04 | 2016-05-11 | 深圳市阳光百度生物科技发展有限公司 | Chitosan povidone-iodine solution and manufacturing technologythereof |
| CN107536828A (en) * | 2016-06-28 | 2018-01-05 | 上海国汇生物科技有限公司 | A kind of skin mucous membrane disinfectants |
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