CN113261559A - Low-temperature quaternary ammonium salt disinfectant and preparation method thereof - Google Patents
Low-temperature quaternary ammonium salt disinfectant and preparation method thereof Download PDFInfo
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 71
- 150000003242 quaternary ammonium salts Chemical class 0.000 title claims abstract description 64
- 238000002360 preparation method Methods 0.000 title abstract description 12
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 29
- 238000003756 stirring Methods 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- -1 ethyl benzyl Chemical group 0.000 claims description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 23
- 239000000243 solution Substances 0.000 claims description 19
- 238000002156 mixing Methods 0.000 claims description 17
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 claims description 11
- 229930182470 glycoside Natural products 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 11
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 9
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 9
- 229920000136 polysorbate Polymers 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 5
- 239000011259 mixed solution Substances 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 150000005846 sugar alcohols Polymers 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical class [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- XKXHCNPAFAXVRZ-UHFFFAOYSA-N benzylazanium;chloride Chemical compound [Cl-].[NH3+]CC1=CC=CC=C1 XKXHCNPAFAXVRZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 34
- 230000000694 effects Effects 0.000 abstract description 27
- 230000001954 sterilising effect Effects 0.000 abstract description 19
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 7
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- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
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- SCXCDVTWABNWLW-UHFFFAOYSA-M decyl-dimethyl-octylazanium;chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCC SCXCDVTWABNWLW-UHFFFAOYSA-M 0.000 description 3
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- 239000002244 precipitate Substances 0.000 description 2
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- 239000003206 sterilizing agent Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
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- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 239000007798 antifreeze agent Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/24—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients to enhance the sticking of the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a low-temperature quaternary ammonium salt disinfectant and a preparation method thereof, belonging to the technical field of disinfection. The quaternary ammonium salt disinfectant comprises the following components in percentage by weight: 0.1-0.6% of quaternary ammonium salt, 1-5% of curing agent, 0.1-0.5% of synergist, 20-50% of antifreezing agent and the balance of water. According to the application, the quaternary ammonium salt, the curing agent, the synergist and the antifreezing agent are sequentially added into water, and the quaternary ammonium salt disinfectant can be obtained by uniformly stirring. The quaternary ammonium salt disinfectant can not freeze at the temperature of-23 ℃, can keep an excellent sterilization effect, has a lasting antibacterial effect, low corrosivity, good stability and convenient operation, does not need to be cleaned after acting on the surface of an object, has the advantages of safety, environmental protection, high efficiency, no toxicity, no odor and the like, and has a wide application prospect.
Description
Technical Field
The invention relates to the technical field of disinfection, in particular to a low-temperature quaternary ammonium salt disinfectant and a preparation method thereof.
Background
2019 the new coronavirus (SARS-CoV-2) is a virus containing lipid membrane, and belongs to the same lipophilic virus as hepatitis B virus, influenza virus, etc. Symptoms of the virus infection are fever, hypodynamia, dry cough and gradual dyspnea, and severe patients show acute respiratory distress syndrome, septic shock, metabolic acidosis and blood coagulation dysfunction which are difficult to correct.
Many viruses can be stored in a refrigerated environment at-4 ℃ for one month, under freezing conditions for years, and can stably survive under ultra-low temperature and freeze-drying conditions. In the process, although the virus cannot be replicated, the biological structure of the virus can be guaranteed not to be damaged, and once the temperature is restored to normal temperature, the virus still can be spread.
Based on previous knowledge of coronaviruses, all classical disinfection methods are able to kill coronaviruses. However, the disinfection effect of most disinfection solutions is directly related to the temperature, generally speaking, under the condition of low temperature, the disinfection effect of the normal temperature disinfection solution is obviously weakened, and when the temperature is lower than 16 ℃, the common disinfection solution loses the effect on most pathogens, even cannot play the disinfection effect at all, and completely fails. The frozen food is stored and sold under the condition of less than or equal to minus 18 ℃, when the outer surface of the package of the frozen food is sterilized by normal-temperature sterilizing liquid, the frozen food can be frozen and frozen quickly, the sterilizing effect is lost, the sterilizing requirement can not be met, and the frozen food is easy to remain, thereby polluting the outer package and even the food.
The quaternary ammonium salt is a cationic surfactant, belongs to a low-efficiency bactericide, can kill most bacterial propagules and lipophilic viruses, has mild and non-irritating components, is suitable for disinfection in hospitals, schools and households, and is widely accepted by consumers. However, the quaternary ammonium salt disinfectant has a not particularly ideal disinfection effect, and particularly has a poorer disinfection effect in a low-temperature environment, so that the use of the quaternary ammonium salt disinfectant is greatly limited. Therefore, it is necessary to provide a quaternary ammonium salt disinfectant with good disinfection effect at low temperature.
Disclosure of Invention
The invention provides a low-temperature quaternary ammonium salt disinfectant and a preparation method thereof, aiming at solving the problem that the existing quaternary ammonium salt disinfectant cannot meet the disinfection requirement under the low-temperature condition.
In a first aspect, the low-temperature quaternary ammonium salt disinfectant disclosed by the invention adopts the following technical scheme.
A low-temperature quaternary ammonium salt disinfectant comprises the following components in percentage by weight:
by adopting the technical scheme, the disinfectant disclosed by the invention contains 4 components, namely quaternary ammonium salt, curing agent, synergist and antifreezing agent. Wherein, the quaternary ammonium salt is an active ingredient and mainly plays a role in disinfection; the synergist has a synergistic effect, and can increase the contact area of the active ingredients and the surfaces of harmful microorganisms and the permeability of cell walls and cell membranes of the harmful microorganisms, so that the resistance of the active ingredients entering the harmful microorganisms is reduced, and the sterilization effect of the active ingredients at low temperature (as low as-23 ℃) is improved; the antifreezing agent is added to play a main antifreezing role, so that the disinfectant can still achieve the disinfection effect and can not freeze under the condition that the temperature is as low as-23 ℃; the quaternary ammonium salt can be attached to the surface of an object by adding the curing agent, so that the quaternary ammonium salt can be fixed and can be exerted on the surface of the object for a long time, and the long-acting antibacterial effect is achieved. Therefore, the disinfectant can keep good sterilization effect at low temperature under the action of the 4 components, and the sterilization effect is durable.
Optionally, the quaternary ammonium salt is selected from C8～C18The quaternary ammonium chloride salt is composed of fatty chain (single chain or double chain), methyl (or benzyl, ethyl benzyl), or benzyl ammonium chloride pinine is composed of pinine, dimethyl, benzyl, or bromide quaternary ammonium salt is composed of fatty chain (single chain or double chain) of C8-C18, methyl (or benzyl, ethyl benzyl).
Through adopting above-mentioned technical scheme, the quaternary ammonium salt of this application chose for use two kinds or more than two kinds as the active ingredient of disinfectant, and the effectual poor problem of single quaternary ammonium salt disinfection effect of having solved makes the disinfection effect of this application disinfectant obtain showing the reinforcing.
Optionally, the synergist is formed by mixing dodecyl dimethyl amine oxide and alkyl glycoside according to the mass ratio of 3 (3-7).
Furthermore, the synergist is formed by mixing dodecyl dimethyl amine oxide and alkyl glycoside according to the mass ratio of 3: 7.
By adopting the technical scheme, the synergist is obtained by reasonably compounding the dodecyl dimethyl amine oxide and the alkyl glycoside, and the bactericidal effect of the quaternary ammonium salt can be remarkably enhanced.
Optionally, the antifreeze agent is one or more of inorganic salt, low-carbon alcohol and polyhydric alcohol.
Optionally, the inorganic salt is sodium chloride, calcium chloride or magnesium chloride; the lower alcohol is methanol, ethanol, butanol or pentanol; the polyalcohol is ethylene glycol, propylene glycol or glycerol.
By adopting the technical scheme, the inorganic salt, the low-carbon alcohol or the polyol is selected as the antifreezing agent, so that the antifreezing effect of the disinfectant can be obviously improved, and the disinfectant can not be frozen at the temperature of-23 ℃.
Optionally, the curing agent is prepared by mixing polydimethylsiloxane and tween according to the mass ratio of 4: 6.
By adopting the technical scheme, the curing agent is obtained by reasonably compounding polydimethylsiloxane and tween, so that the adhesive force of the quaternary ammonium salt attached to the surface of an object is improved, and the disinfectant has a long-acting antibacterial effect.
In a second aspect, the present application provides a method for preparing a low-temperature quaternary ammonium salt disinfectant, which adopts the following technical scheme.
The preparation method of the low-temperature quaternary ammonium salt disinfectant comprises the following steps:
s1, weighing quaternary ammonium salt, a curing agent, an antifreezing agent, a synergist and water in specified amounts;
s2, mixing water and quaternary ammonium salt, and stirring at 30-50rpm/min for 20-30 min;
s3, adding a curing agent into the solution obtained in the step S2, and stirring at 30-50rpm/min for 20-30 min;
s4, adding the synergist into the mixed solution obtained in the step S3, and stirring at 30-50rpm/min for 10-15 min;
s5, adding an antifreezing agent into the mixed liquid obtained in the step S4, and stirring at 30-50rpm/min for 15-20min to obtain the antifreezing agent.
By adopting the technical scheme, the production process of the quaternary ammonium salt disinfectant is simple, the operation is safe, and the quaternary ammonium salt disinfectant is suitable for large-scale industrial production.
The present invention obtains the following advantageous effects.
1. The quaternary ammonium salt disinfectant can be in a colorless transparent liquid state at the temperature of-23 ℃, and does not precipitate or crystallize, thereby laying a foundation for the low-temperature sterilization effect;
2. the quaternary ammonium salt disinfectant can still keep excellent sterilization effect at the temperature of 23 ℃ below zero, can effectively kill pathogenic bacteria in intestinal tracts and pyococcus, and can completely kill pathogenic bacteria in 30 min;
3. the quaternary ammonium salt disinfectant has good stability, can be stored for about 2 years at normal temperature, and has long use validity period;
4. the quaternary ammonium salt disinfectant can be attached to the surface of a target object for a long time, so that a long-acting antibacterial effect is achieved;
5. the quaternary ammonium salt disinfectant has low corrosivity, is not required to be wiped and cleaned when being sprayed on the surface of an object, is safe to environment and organisms, and has no toxic or side effect;
6. the preparation method of the quaternary ammonium salt disinfectant is simple, and the prepared quaternary ammonium salt disinfectant is convenient to use and can be directly used without dilution.
Detailed Description
The present invention will be further described with reference to examples.
Example 1
A preparation method of a low-temperature quaternary ammonium salt disinfectant comprises the following steps:
s1, weighing 0.5g of octyl decyl dimethyl ammonium chloride, 0.5g of didecyl dimethyl ammonium chloride, 4g of polydimethylsiloxane, 6g of tween, 2.5g of dodecyl dimethyl amine oxide, 2.5g of alkyl glycoside, 200g of ethanol and 784g of water;
s2, mixing water and quaternary ammonium salt, and stirring at 30rpm/min for 30 min;
s3, mixing polydimethylsiloxane and tween in advance, then adding the mixture into the solution obtained in the step S2, and stirring the mixture for 30min at a speed of 30 rpm/min;
s4, pre-mixing dodecyl dimethyl amine oxide and alkyl glycoside, then adding the mixture into the mixed solution obtained in the step S3, and stirring the mixture for 15min at 30 rpm/min;
s5, adding ethanol into the mixed liquid obtained in the step S4, and stirring at 30rpm/min for 20min to obtain the composite material.
Example 2
A preparation method of a low-temperature quaternary ammonium salt disinfectant comprises the following steps:
s1, weighing 3g of octyl decyl dimethyl ammonium chloride, 3g of didecyl dimethyl ammonium chloride, 20g of polydimethylsiloxane, 30g of tween, 0.3g of dodecyl dimethyl amine oxide, 0.7g of alkyl glycoside, 500g of ethanol and 443g of water;
s2, mixing water and quaternary ammonium salt, and stirring at 30rpm/min for 30 min;
s3, mixing polydimethylsiloxane and tween in advance, then adding the mixture into the solution obtained in the step S2, and stirring the mixture for 30min at a speed of 30 rpm/min;
s4, pre-mixing dodecyl dimethyl amine oxide and alkyl glycoside, then adding the mixture into the mixed solution obtained in the step S3, and stirring the mixture for 15min at 30 rpm/min;
s5, adding ethanol into the mixed liquid obtained in the step S4, and stirring at 30rpm/min for 20min to obtain the composite material.
Example 3
A preparation method of a low-temperature quaternary ammonium salt disinfectant comprises the following steps:
s1, weighing 2g of octyl decyl dimethyl ammonium chloride, 2g of didecyl dimethyl ammonium chloride, 4g of polydimethylsiloxane, 6g of tween, 1.5g of dodecyl dimethyl amine oxide, 3.5g of alkyl glycoside, 300g of ethanol and 681g of water;
s2, mixing water and quaternary ammonium salt, and stirring at 30rpm/min for 30 min;
s3, mixing polydimethylsiloxane and tween in advance, then adding the mixture into the solution obtained in the step S2, and stirring the mixture for 30min at a speed of 30 rpm/min;
s4, pre-mixing dodecyl dimethyl amine oxide and alkyl glycoside, then adding the mixture into the mixed solution obtained in the step S3, and stirring the mixture for 15min at 30 rpm/min;
s5, adding ethanol into the mixed liquid obtained in the step S4, and stirring at 30rpm/min for 20min to obtain the composite material.
Comparative example 1
A commercial quaternary ammonium salt disinfectant.
Comparative example 2
The difference between the preparation method of the low-temperature quaternary ammonium salt disinfectant and the embodiment 3 is that: no curing agent and no synergist were included, and the operations of steps S3 and S4 were not performed.
Comparative example 3
The difference between the preparation method of the low-temperature quaternary ammonium salt disinfectant and the embodiment 3 is that: the operation of step S3 is not performed without containing a curing agent.
Performance detection
1. Detection of anti-freezing effect
The disinfectant solutions of examples 1 to 3 and comparative examples 1 to 3 of the present application were tested for their antifreeze effect according to the low-temperature test described in the notice of the technical requirements for evaluation of sanitary safety of low-temperature disinfectants issued by the national institutes of health and wellness.
5ml of the disinfecting solutions of examples 1 to 3 and comparative examples 1 to 3 were respectively placed at a low temperature of-23 ℃ overnight (>8h), and the shapes thereof were observed and recorded. The low-temperature disinfectant is judged to be qualified if the low-temperature disinfectant is kept in a liquid state and has no precipitation or crystallization. The results of the experiment are shown in Table 1.
TABLE 1
| Observe for 8h | Observe for 10h | Observe for 12h | Observation for 14h | Observe for 16h | Observe for 18h | |
| Example 1 | Qualified | Qualified | Qualified | Qualified | Qualified | Qualified |
| Example 2 | Qualified | Qualified | Qualified | Qualified | Qualified | Qualified |
| Example 3 | Qualified | Qualified | Qualified | Qualified | Qualified | Qualified |
| Comparative example 1 | Fail to be qualified | Fail to be qualified | Fail to be qualified | Fail to be qualified | Fail to be qualified | Fail to be qualified |
| Comparative example 2 | Qualified | Qualified | Qualified | Qualified | Qualified | Qualified |
| Comparative example 3 | Qualified | Qualified | Qualified | Qualified | Qualified | Qualified |
As can be seen from Table 1, the disinfectant of examples 1-3 of the present application remained in a liquid state after being frozen at-23 ℃ for 18 hours, and did not precipitate or crystallize, whereas the commercially available disinfectant was frozen and frozen after being frozen at-23 ℃ for 8 hours, and lost the disinfection effect, and did not meet the disinfection requirement.
2. Sterilization effect detection
According to the technical specification of disinfection, the disinfection solution of example 3 and comparative example 1 is adopted to act on escherichia coli (8099) and staphylococcus aureus (ATCC 6538) on the cloth for 30min at the temperature of 0 ℃ to-23 ℃, the killing logarithm value (carrier method) is determined, each group of experiments is carried out for three times, and the average value is taken. The results are shown in Table 2.
TABLE 2
As can be seen from Table 2, under the condition of 0 ℃, the killing logarithm value of the disinfectant sold in the market is obviously reduced, while the killing logarithm value of the disinfectant of the embodiment is not obviously reduced, so that the disinfectant has strong sterilization effect; with the reduction of the temperature, the sterilizing effect of the commercially available sterilizing agent is continuously reduced, but although the sterilizing effect of the sterilizing agent in the embodiment of the application is slightly reduced, the killing logarithm value is more than 3.00, and the sterilizing requirement can be completely met.
3. Effect of synergist on fungicidal Effect
According to the technical specification of disinfection, the disinfectant solution of example 3 and comparative examples 2-3 is used for acting on escherichia coli (8099) and staphylococcus aureus (ATCC 6538) on a cloth piece for 30min at the temperature of 0 ℃ to-23 ℃, the killing pair value (carrier method) is measured, each group of experiments are carried out for three times, and an average value is taken. The results are shown in Table 3.
TABLE 3
As can be seen from Table 3, the addition of the synergist greatly improves the sterilizing effect of the disinfectant, and the experimental results show that the synergist can play a synergistic role in quaternary ammonium salt, so that the disinfectant still keeps an excellent sterilizing effect at low temperature.
4. Effect of curing Agents on Sterilization
Sample pieces are prepared by adopting the quaternary ammonium salt disinfectant of the embodiment 3 and the comparative example 3, after the sample pieces are stored for 7 days at room temperature, escherichia coli, staphylococcus aureus and candida albicans are respectively inoculated on the sample pieces, the action is carried out for 30min, and the sterilization performance of the disinfectant of the embodiment 3 and the comparative example 3 is measured. The results are shown in Table 4.
TABLE 4
As can be seen from Table 4, the average sterilization rate of the disinfectant of example 3 is 100% for Escherichia coli, Staphylococcus aureus and Candida albicans stained on the sample, and the continuous antibacterial ability is strong for 7 days.
The difference between comparative example 3 and example 3 is the addition of the curing agent, and as can be seen from table 4, the antiseptic solution of comparative example 3 without the curing agent has a weak lasting antiseptic ability, while the antiseptic solution of example 3 with the curing agent added has a lasting antiseptic ability of 7 days.
5. Stability test
The disinfectant solutions of example 3 and comparative example 1 of the present application were allowed to stand at-23 ℃ for 24 hours and at 37 ℃ for 14 days, respectively, and the quaternary ammonium salt content of the disinfectant solutions before and after the standing was measured (3 parallel tests were performed for both example 3 and comparative example 1). The test results are shown in tables 5-6.
TABLE 5 stability before and after standing at-23 deg.C
TABLE 637 ℃ stability before and after storage
As can be seen from tables 5-6, the disinfectant of the embodiment 3 of the application is placed at-23 ℃ for 24 hours, and the content of quaternary ammonium salt is not reduced basically; after the disinfectant liquid is placed for 14 days at 37 ℃, the content reduction rate of the quaternary ammonium salt is less than 10 percent, so that the validity period of the disinfectant liquid can be judged to be 2 years.
6. Corrosion test of metals
The metal pieces were immersed in the disinfectant solutions of example 3 and comparative example 1 for 72 hours in succession, and the corrosiveness of the disinfectant solutions was measured (three times for each set of experiments, and the average value was taken). The results are shown in Table 7.
TABLE 7
As can be seen from Table 7, the disinfectant of example 3 of the present application has substantially no corrosion to stainless steel, and has only slight corrosion to carbon steel and aluminum, and the corrosion is low.
7. Toxicological test
Mice and rabbits were treated with the disinfectant of example 3 of the present application, with the results: acute oral toxicity LD of mice50More than 5000mg/kg of body weight, which is an actual nontoxic substance; the mouse has no chromosome damage effect and does not mutate; the stimulation reaction of erythema and edema is caused to the intact skin of the rabbit, the highest integral mean value (stimulation index) is 0, and the rabbit can be judged to be non-irritant to the skin.
The embodiments of the present invention are the preferred embodiments of the present invention, and the scope of the present invention is not limited by the embodiments, so: all equivalent changes made according to the structure, shape and principle of the invention are covered within the protection scope of the invention.
Claims (8)
1. A low-temperature quaternary ammonium salt disinfectant is characterized in that: comprises the following components in percentage by weight:
the balance being water.
2. The low-temperature quaternary ammonium salt disinfectant as set forth in claim 1, wherein: the quaternary ammonium salt is selected from C8～C18The quaternary ammonium chloride salt is composed of fatty chain (single chain or double chain), methyl (or benzyl, ethyl benzyl), or benzyl ammonium chloride pinine is composed of pinine, dimethyl, benzyl, or bromide quaternary ammonium salt is composed of fatty chain (single chain or double chain) of C8-C18, methyl (or benzyl, ethyl benzyl).
3. The low-temperature quaternary ammonium salt disinfectant as set forth in claim 1, wherein: the synergist is formed by mixing dodecyl dimethyl amine oxide and alkyl glycoside according to the mass ratio of 3 (3-7).
4. The low-temperature quaternary ammonium salt disinfectant as set forth in claim 3, wherein: the synergist is formed by mixing dodecyl dimethyl amine oxide and alkyl glycoside according to the mass ratio of 3: 7.
5. The low-temperature quaternary ammonium salt disinfectant as set forth in claim 1, wherein: the antifreezing agent is one or more of inorganic salt, low-carbon alcohol and polyhydric alcohol.
6. The low-temperature quaternary ammonium salt disinfectant as set forth in claim 5, wherein: the inorganic salt is sodium chloride, calcium chloride or magnesium chloride; the lower alcohol is methanol, ethanol, butanol or pentanol; the polyalcohol is ethylene glycol, propylene glycol or glycerol.
7. The low-temperature quaternary ammonium salt disinfectant as set forth in claim 1, wherein: the curing agent is prepared by mixing polydimethylsiloxane and tween according to the mass ratio of 4: 6.
8. A method for preparing the low-temperature quaternary ammonium salt disinfectant solution as set forth in any one of claims 1 to 7, which comprises: the method comprises the following steps:
s1, weighing quaternary ammonium salt, a curing agent, an antifreezing agent, a synergist and water in specified amounts;
s2, mixing water and quaternary ammonium salt, and stirring at 30-50rpm/min for 20-30 min;
s3, adding a curing agent into the solution obtained in the step S2, and stirring at 30-50rpm/min for 20-30 min;
s4, adding the synergist into the mixed solution obtained in the step S3, and stirring at 30-50rpm/min for 10-15 min;
s5, adding an antifreezing agent into the mixed liquid obtained in the step S4, and stirring at 30-50rpm/min for 15-20min to obtain the antifreezing agent.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113892485A (en) * | 2021-10-29 | 2022-01-07 | 广州汇纳生物科技有限公司 | Low-temperature freezing disinfectant and preparation method and application thereof |
| CN114868759A (en) * | 2022-07-11 | 2022-08-09 | 北京中科领德医药科技有限公司 | Long-acting quaternary ammonium salt disinfectant and preparation method thereof |
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| CN106912485A (en) * | 2017-03-16 | 2017-07-04 | 杭州易路医疗器械有限公司 | Compound double-chain quaternary ammonium salt thimerosal and its application method and application |
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| CN101926353A (en) * | 2010-07-07 | 2010-12-29 | 高旭 | Disinfectant in field of food and preparation method |
| CN103749445A (en) * | 2013-12-31 | 2014-04-30 | 中国船舶重工集团公司第七一八研究所 | Compound o-phthalaldehyde disinfection concentrated liquid |
| CN106912485A (en) * | 2017-03-16 | 2017-07-04 | 杭州易路医疗器械有限公司 | Compound double-chain quaternary ammonium salt thimerosal and its application method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113892485A (en) * | 2021-10-29 | 2022-01-07 | 广州汇纳生物科技有限公司 | Low-temperature freezing disinfectant and preparation method and application thereof |
| CN114868759A (en) * | 2022-07-11 | 2022-08-09 | 北京中科领德医药科技有限公司 | Long-acting quaternary ammonium salt disinfectant and preparation method thereof |
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