CN101548683A - Liquid disinfectant and method of producing the same - Google Patents
Liquid disinfectant and method of producing the same Download PDFInfo
- Publication number
- CN101548683A CN101548683A CN 200910114009 CN200910114009A CN101548683A CN 101548683 A CN101548683 A CN 101548683A CN 200910114009 CN200910114009 CN 200910114009 CN 200910114009 A CN200910114009 A CN 200910114009A CN 101548683 A CN101548683 A CN 101548683A
- Authority
- CN
- China
- Prior art keywords
- disinfectant
- skin
- same
- minutes
- biguanides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a liquid disinfectant suitable for hospital and other places, and method of producing the same. The method adopts polyamine propyl biguanide with strong sterilizing force, good stability and no skin hypersusceptibility phenomena as the main ingredient; selects nonylphenol polyethenoxy ether as surfactant, which can not only enhances the bactericidal effect, but also increases the product stability; adds fragrance to make the disinfectant have the fragrance smell, the simple proportioning reaches the same disinfecting effect. The invention has advantage of low fabricating cost and simple preparation technique, and is simultaneously non-toxic non-corrosive, thereby minimizing the impact on the surrounding environment.
Description
Technical field
The present invention relates to the disinfectant field, especially be applicable to the liquid disinfectant in places such as hospital.
Background technology
Natural world exists various microorganisms, comprise various bacterial propagules, fungi, gemma, virus etc., wherein the pathogenic microorganism that human body is worked the mischief must be killed removing, therefore, outside 20th-century disease pathogenic microorganism is carried out timely and effective sterilization, prevent disease is propagated, and control inside-hospital infection and guarantee health of people are of great significance.
Can select the number of chemical disinfectant to environment disinfected at present, commonly used have chloride class disinfectant, aldehyde disinfectant, peroxide disinfectant, iodine class disinfectant, alcohol disinfectant, a quaternary ammonium disinfectant etc., they have pluses and minuses separately respectively, remarkable as chloride class disinfectant, aldehyde disinfectant, peroxide sanitizer disinfecting effect, belong to high effect disinfectants, but the corrosivity to article is higher, especially not only corrosivity is strong for chloride class disinfectant, aldehyde disinfectant, and tanginess, bigger to skin and mucous membrane irritation, stability is also relatively poor; In recent years, the biguanides disinfectant more and more is much accounted of, the scope of application is also more and more extensive, it not only has stronger killing action to bacterium and germ, and have colourless, tasteless, nontoxic, non-corrosive good characteristic, can be widely used in the disinfection of body surface, air, skin and mucous membrane.
Have much about the biguanides disinfectant at present, prescription is complicated mostly, and composition is on the high side.(application number: 03139646.1), composition comprised 9 kinds of quaternary ammonium salt, biguanides, aldehydes, surfactant, urea, EDTA sodium salts etc. as disclosed Chinese patent application on February 25 " liquid disinfectant " in 2004; November in 2006 Granted publication on the 8th United States Patent (USP) " fast acting disinfectant and cleaner " (application number: 00802830.3) composition comprises multiple compositions such as poly double-guanidine, quaternary ammonium salt, multivalent intercalating agent and surfactant, not only cause preparation technology numerous and diverse, and increased production cost.
Summary of the invention
The invention provides a kind of liquid disinfectant, under the prerequisite that does not reduce sterilization effect, solved disinfectant formula components complexity in the past, preparation is numerous and diverse, cost is higher problem.
Another object of the present invention provides the preparation method of aforesaid liquid disinfectant.
Liquid disinfectant of the present invention, said composition is composed of the following components by weight percentage:
Biguanides 0.8～1.0%
Surfactant 0.2%
Essence 0.06%
Ionized water 98.94%
Biguanides in the above-mentioned component is a polyamine propyl group biguanides.
Surfactant in the above-mentioned component is a polyoxyethylene nonylphenol ether.
Prepare the method for disinfectant of the present invention, mainly may further comprise the steps:
(1) surfactant is mixed with biguanides, stirred 15 minutes;
(2) essence is joined in the mixed liquor, stirred 5 minutes;
(3) ionized water is joined in the above-mentioned solution, stirred 10 minutes;
Above steps is all carried out at normal temperatures and pressures.
The present invention is by selecting for use sterilizing power strong, good stability and be main component to the polyamine propyl group biguanides that skin does not have an allergic phenomena, select for use polyoxyethylene nonylphenol ether as surfactant, thereby disinfectant is adsorbed on prolongs its time of contact on the carrier, not only strengthened bactericidal effect, and increased the stability of product, adding essence makes disinfectant possess faint scent, simple proportioning reaches same Disinfection Effect, therefore to have a production cost low in the present invention, the simple advantage of preparation technology, simultaneously because nontoxic non-corrosiveness has reduced the influence to surrounding enviroment to greatest extent.
Embodiment
Liquid disinfectant of the present invention is main component with the biguanides, ratio in prescription joins polyamine propyl group biguanides to polyoxyethylene nonylphenol ether, stirred 15 minutes at reactor under the normal temperature and pressure, make it to form compound chemical thimerosal 1, add essence then, continue to stir 5 minutes, form thimerosal 2 at reactor, then add ionized water, stir and to obtain disinfectant of the present invention in 10 minutes.
Get disinfectant of the present invention and carry out sterilization, sterilization, metal erosion, test such as allergic, embodiment is as follows:
Embodiment 1: for the Escherichia coli killing effect
Under 19 ℃ of-20 ℃ of conditions of temperature, with the thimerosal of the present invention that contains polyamine propyl group biguanides 0.8%, 0.85%, 1.0% enterobacteria is acted on 15min, 30min, 45min respectively, test repeats 3 times, on average kills logarithm value all＞5.00, it is qualified to be judged to be sterilization, the results are shown in Table 1:
Table 1 thimerosal is to colibacillary killing effect
Embodiment 2: to the Candida albicans killing effect
Under 19 ℃ of-20 ℃ of conditions of temperature, respectively with containing the thimerosal of the present invention of polyamine propyl group biguanides 0.8%, 0.85%, 1.0% to Candida albicans effect 15min, 30min, 45min, test repeats 3 times, on average kill logarithm value to be respectively＞3.51,＞4.00,＞4.00, the results are shown in Table 2:
Annotate: the negative control asepsis growth
Table 2 thimerosal is to the oidiomycetic killing effect of white
Embodiment 3: to the surface disinfection field trial
Under 22 ℃ of conditions of temperature, use the thimerosal of the present invention that contains polyamine propyl group biguanides 0.8%, 0.85%, 1.0% to desktop, table top, go-cart surface, refrigerator surface etc. are acted on 30 minutes respectively, test repeats 3 times, and the logarithm value of on average killing of natural bacteria is 1.27, the results are shown in Table 3:
Table 3 thimerosal is to the surface disinfection site test results
Embodiment 4: to the ground sterilization field trial
Under 22 ℃ of conditions of temperature, respectively with the thimerosal effect of the present invention 30 minutes that contains polyamine propyl group biguanides 0.8%, 0.85%, 1.0%, be 1.03 to the logarithm value of on average killing of cement flooring, smooth earth natural bacteria, the results are shown in Table 4:
Table 4 thimerosal is to the ground sterilization site test results
Embodiment 5: to metal corrosion test
Under 22 ℃ of conditions of temperature, test with the thimerosal that contains polyamine propyl group biguanides 0.8%, 0.85%, 1.0% respectively, stainless corrosion rate is 0.0041mm/a, Corrosion rate in Carbon Steel is 0.1339mm/a, the corrosion rate of copper is 0.0806mm/a, is 0.0705mm/a to the corrosion rate of aluminium that the control group corrosion rate is 0.016mm/a.The results are shown in following table 5:
| Can belong to kind | Average weight (g/ sheet) before the test | Test back average weight (g/ sheet) | Corrosion rate (mm/a) |
| Stainless steel | 3.4620 | 3.4618 | 0.0041 |
| Carbon steel | 3.4110 | 3.4026 | 0.1339 |
| Copper | 3.6367 | 3.6312 | 0.0806 |
| Aluminium | 1.1389 | 1.1374 | 0.0705 |
| Contrast | 3.43329 | 3.4328 | 0.0016 |
Table 5 thimerosal is to the corrosion of metal degree
Embodiment 6: the test of rat acute toxicity on inhalation
1. tried thing: the thimerosal of the present invention that contains polyamine propyl group biguanides 0.8%, 0.85%, 1.0%;
2. animal and feed: animal is 20 of Adult SD kind big white mouse, and body weight is 180-220g, animal housing's temperature: 22-25 ℃, and relative moisture: 55--70%.
3. test method: issue the acute toxicity on inhalation experimental technique of " disinfection technology standard " (version in 2002) 2.3.2 according to the Ministry of Public Health.Adopt nearly formula contamination method, operation instruction is per sample established 10000mg/m
3A concentration.Test is put into 0.81*0.81*0.91m with 10 rats (female male half and half) at every turn at twice
3(volume 0.6m
3) airtight lucite cabinet in, spray into the 6g sample solution with sprayer, start the small fan in the cabinet simultaneously, contaminated 2 hours, the poisoning manifestations of observed and recorded animal is weighed weekly once, observes 14 day time, off-test is dissected animal and is carried out gross examination of skeletal muscle, is tried the acute toxicity power of thing by the toxicity grading standard evaluation.
4. experimental result: after contamination process and contamination finish, do not see that poisoning symptom appears in animal, no animal dead, off-test dissection gross examination of skeletal muscle no abnormality seen.
Embodiment 7: the skin irritatin test
1. tried thing: the thimerosal of the present invention that contains polyamine propyl group biguanides 0.8%, 0.85%, 1.0%;
2. animal and feed: provide by Guangxi Medical University experimental animal center.Animal is 4 of healthy adult white rabbit, body weight 2.0-2.4kg, female, male dual-purpose, animal housing's temperature: 22-25 ℃, relative moisture: 55-75%.
3. test method: issue " disinfection technology standard " (version in 2002) 2.3.3 skin irritatin test method according to the Ministry of Public Health, adopt a time skin irritatin test method.24h cuts tame rabbit back backbone for twice mao left and right each the about 9cm of unhairing scope before the experiment
2Get the 0.5mL sample solution and be applied on the one side skin of unhairing of rabbit back, scope 2.5cm*2.5cm covers with two layers of gauze of the same area and one deck glassine paper then, fixes with medical proof fabric again, and opposite side skin compares.Applied ointment or plaster 4 hours, and removed then and tried thing, clean skin, observed skin reaction in 1,24 and 48 hour after being tried thing in removing.
4. experimental result: remove tried thing after, each is observed the time point rabbit and is tried skin and there is no unusually, contrast skin no abnormality seen press disinfectant the skin irritatin intensity evaluation is stipulated that this sample is to rabbit skin nonirritant.Result of the test sees the following form 6:
Stimulus intensity classification: nonirritant
Table 6 is tried thing to irritant reaction grade form of rabbit skin
Claims (2)
1, a kind of liquid disinfectant, said composition is composed of the following components by weight percentage:
Polyamine propyl group biguanides 0.8～1.0%
Polyoxyethylene nonylphenol ether 0.2%
Essence 0.06%
Ionized water 98.94%
2, the method for preparing the described disinfectant of claim 1 is characterized in that this method may further comprise the steps composition:
(a) polyamine propyl group biguanides is mixed with polyoxyethylene nonylphenol ether, stirred 15 minutes, form mixed liquor 1;
(b) essence is joined in the mixed liquor 1, stirred 5 minutes, obtain mixed liquor 2;
(c) ionized water is joined in the mixed liquor 2, stir and to obtain described thimerosal in 10 minutes;
Above steps is all carried out at normal temperatures and pressures.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910114009 CN101548683B (en) | 2009-04-25 | 2009-04-25 | Liquid disinfectant and method of producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910114009 CN101548683B (en) | 2009-04-25 | 2009-04-25 | Liquid disinfectant and method of producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101548683A true CN101548683A (en) | 2009-10-07 |
| CN101548683B CN101548683B (en) | 2013-02-13 |
Family
ID=41153360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200910114009 Expired - Fee Related CN101548683B (en) | 2009-04-25 | 2009-04-25 | Liquid disinfectant and method of producing the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101548683B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104170879A (en) * | 2014-08-01 | 2014-12-03 | 青岛蓬勃石油技术服务有限公司 | Anticorrosive bactericide for oilfield reinjection water and preparation method of anticorrosive bactericide |
| CN111374142A (en) * | 2020-03-12 | 2020-07-07 | 天天向上(宁波)医疗科技有限公司 | Disinfecting emulsion, preparation method thereof and disinfecting wet tissue prepared from disinfecting emulsion |
| CN112741116A (en) * | 2021-01-15 | 2021-05-04 | 四川恒博生物科技有限公司 | Silver ion composite disinfection and sterilization sporicide based on hydrogen peroxide |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1391809A (en) * | 2002-08-12 | 2003-01-22 | 杨生 | Skin sterilizing agent before operation |
| CN1476761A (en) * | 2003-07-02 | 2004-02-25 | 刘瑞源 | Liquid disinfectant |
| CN100531706C (en) * | 2007-10-29 | 2009-08-26 | 广东庆发药业有限公司 | Antimicrobial disinfection hand cleanser and preparation method thereof |
-
2009
- 2009-04-25 CN CN 200910114009 patent/CN101548683B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104170879A (en) * | 2014-08-01 | 2014-12-03 | 青岛蓬勃石油技术服务有限公司 | Anticorrosive bactericide for oilfield reinjection water and preparation method of anticorrosive bactericide |
| CN111374142A (en) * | 2020-03-12 | 2020-07-07 | 天天向上(宁波)医疗科技有限公司 | Disinfecting emulsion, preparation method thereof and disinfecting wet tissue prepared from disinfecting emulsion |
| CN112741116A (en) * | 2021-01-15 | 2021-05-04 | 四川恒博生物科技有限公司 | Silver ion composite disinfection and sterilization sporicide based on hydrogen peroxide |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101548683B (en) | 2013-02-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102077828A (en) | Compound disinfectant containing quaternary ammonium salt | |
| CN107536727A (en) | A kind of disposable skin of hand antimicrobial spume and preparation method thereof | |
| JP3507347B2 (en) | Aqueous liquid containing humus extract material | |
| CN113491709B (en) | Multifunctional high-efficiency compound disinfectant and preparation method thereof | |
| CN101548983B (en) | Skin disinfectant and method of producing the same | |
| CN109777639A (en) | It is a kind of for air-conditioning and the disinfection of general object hard surface and the preparation of hygiene and preparation method thereof | |
| US20060075922A1 (en) | Controlled-acidity composition | |
| JP2008007451A (en) | Sterilizer | |
| CN108157358A (en) | A kind of thimerosal and preparation method thereof | |
| Boucher | Potentiated acid 1, 5 pentanedial solution—a new chemical sterilizing and disinfecting agent | |
| CN101548683B (en) | Liquid disinfectant and method of producing the same | |
| RU2407547C2 (en) | Agent for disinfecting and sanitising air | |
| CN1480221A (en) | Washing free gel for disinfection | |
| CN113100255A (en) | Composite nano-silver pet deodorizing disinfectant and preparation method thereof | |
| CN104815096A (en) | Nano composite skin disinfection emulsion and preparation method of same | |
| CN104886110B (en) | A kind of multiduty composite cation surfactant disinfectants | |
| CN101537000A (en) | Multi-purpose disinfectant | |
| CN103110541A (en) | All-natural washing-free disinfectant hand sanitizer | |
| CN112868665B (en) | Disinfectant containing supermolecule silver and preparation method thereof | |
| CN104434994A (en) | Mucocutaneous disinfectant | |
| CN113521042A (en) | Alcohol-free wash-free virus inactivation disinfectant special for children and preparation method thereof | |
| CN102461499B (en) | Disinfector for remains and preparation method thereof | |
| KR102358238B1 (en) | Sterilization, deodorization and Cleansing effect excellent Therawater Alkali ionized water composition and manufacturing method | |
| Olorode et al. | Antimicrobial activities of chlorhexidine gluconate and cetrimide against pathogenic microorganisms isolated from slaughter houses in Rivers State, Nigeria | |
| KR20100001244A (en) | Aprocessing method of antibacterial moisturing liquid made by deep seaelectronic water and the antibacterial moisturing liquid made by deepseaelectronic water thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Su Xuankui Inventor after: Zhao Shenglin Inventor before: Su Xuankui |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: SU XUANKUI TO: SU XUANKUI ZHAO SHENGLIN |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130213 Termination date: 20170425 |