CN1480221A - Washing free gel for disinfection - Google Patents
Washing free gel for disinfection Download PDFInfo
- Publication number
- CN1480221A CN1480221A CNA031303838A CN03130383A CN1480221A CN 1480221 A CN1480221 A CN 1480221A CN A031303838 A CNA031303838 A CN A031303838A CN 03130383 A CN03130383 A CN 03130383A CN 1480221 A CN1480221 A CN 1480221A
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- China
- Prior art keywords
- triclosan
- gel
- agent
- disinfecting gel
- thickening agent
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Abstract
A non-washing disinfecting gel for disinfecting human skin and surface of object is prepared from triclosan, alcohol, moistening agent, thickening agent, pH regulator and deionized water through dissolving triclosan in alcohol, and sequentially adding others while stirring. It can be used to prevent SARS, hepatitis A, hepatitis B, and AIDS.
Description
Technical field
The present invention relates to a kind of disinfectant, particularly a kind of disposable disinfecting gel, and it can be widely used in daily life, have good sterilization effect and the disposable disinfecting gel of lasting fungistatic effect is arranged.This disinfecting gel is with triclosan (2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether) be main component, being equipped with suitable solvent, thickening agent or excipient, nertralizer and wetting agent is prepared from, can be used for sterilization, the sterilization, antibacterial of skin and body surface, the generation of prevention contact infectious disease.
Background technology
Occurring in nature extensively exists various microorganisms, and some microorganism under certain condition can be to human body and environment structure harm.The disease that is caused by cause pathogeny imcrobe infection remains one of main threat that faces in the human survival, and often there is new pathogen to find, though people have adopted the method for variety of way in antimicrobial struggle, sterilization is still the effective means of fundamental sum the most.Sterilization is meant the method for pathogenic microbe killing, is referred to as disinfectant (Disinfectants) in order to the disinfectant medicine.Because the raising of people's living standard, the enhancing of Personal hygiene and personal protection consciousness, to the requirement of sterile products and use more and more general-from being usually used in the common disinfectant of environment disinfected, to sterilization water preparation used in everyday, disinfecting gel, there has been multiple convenient and practical sterile products to come out now; Along with society and expanding economy, the quickening of people's rhythm of life, property requirement to the daily convenient articles for use that use is more and more higher, and its demand also begins to increase sharply-and wherein the disinfectant of gel dosage form has become a kind of Personal hygiene sterilizing article that is popular with its characteristics easy to use.
Efficiently, safety, wide spectrum, antimicrobial activity composition pollution-free and that can have a good compatibility with corresponding adjuvant are the first-selections of disinfecting gel preparation.Triclosan is exactly a kind of disinfectant that is widely used with these characteristics and advantage.Triclosan, chemical name 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether, it is popular in the world at present broad-spectrum high efficacy antibacterial, Gram-positive and negative bacteria, chlamydia, spirillum, mycoplasma, fungus and virus (as hepatitis A, hepatitis B virus, HIV (human immunodeficiency virus) HIV etc.) etc. are all had kill widely and inhibitory action, and have instantaneous sterilization and lasting fungistatic effect.Triclosan is the nonionic active component, good with daily use chemicals material combination commonly used, there is not acute and chronic toxic chemical compound, can induced hypersensitivity reaction, no mutagenicity and teratogenecity, non-carcinogenesis, no any optical sensibilization and photic toxicity, and do not accumulate in organ and the tissue in vivo, almost pollution-free to environment.Because the triclosan broad-spectrum kills/bacteriostasis, have simultaneously be not infected with product and skin, no any penetrating odor, to human body and Environmental security, outstanding advantage such as have no side effect, therefore be widely used as the sterilization and the bacteriostatic effective ingredient of efficient medicated soap, health fancy soap, health body lotion, anti-plaque dental care product, cleaning product, toothpaste, collutory, cosmetics, cleansing milk, air freshener, wound and medical apparatus sterilizing agent, fabric and leather sanitary finish agent etc.The product that document or patent are reported or as skin care implement (having report to contain the Aloe gel conditioning liquids of trichloro hydroxyl diphenyl ether 0.29%, ethanol, Aloe etc.) or as cleaning supplies (as US 5955408, EP0882446 etc.) or as disinfectant (as CA1245012, the gentle disinfecting gel of clean cottonrose hibiscus) as patent WO 9802137, patent US 5730963, document, but do not have to play synergistic active component.
Summary of the invention
The purpose of this invention is to provide a kind of disposable disinfecting gel, the present invention is according to the good compatibility of triclosan and number of chemical raw material, utilize ethanol and the synergistic activity of triclosan instantaneous sterilization and triclosan to continue the bacteriostatic characteristics, be developed into and have the extremely disposable gel disinfectant of bacteriostasis efficacy.The present invention can be used for sterilization, the sterilization, antibacterial of skin and body surface, the generation of prevention contact infectious disease (for example SARS, hepatitis A, hepatitis B virus, HIV (human immunodeficiency virus) HIV etc.).
The present invention is to be main effectively active component with triclosan (2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether), is equipped with to comprise that medical formulation preparation forms.
The present invention includes cooperative effect agent and etoh solvent.
The present invention also comprises thickening agent carbopol 934, carbopol 940 or carbopol Ultrez-10.
The present invention also comprises acid-base modifier triisopropanolamine, triethanolamine or diisopropanolamine (DIPA); And wetting agent is a glycerol.
Composition of the present invention and mass ratio prescription: triclosan 0.05%-0.5%, ethanol 60%-70%, wetting agent 1%-5%, thickening agent 0.1%-0.5%, acid-base modifier 0.2%-0.6%, deionized water 23%-39%.
Composition of the present invention and mass ratio prescription can be: triclosan 0.1%-0.2%, ethanol 60%-70%, wetting agent 1%, thickening agent 0.2%-0.3%, acid-base modifier 0.3%-0.45%, deionized water 23%-39%.
It is the solvent and the cooperative effect agent of triclosan that the present invention selects the ethanol of high concentration for use, its concentration is up to 60-70% (mass ratio), the volume by volume concentration that is equivalent to 65-75%, triclosan was effectively dissolved, because ethanol also has good bactericidal action, also can work in coordination with the bactericidal action that realizes quick acting simultaneously with triclosan.In the preparation process of disinfecting gel, for making manufactured goods present transparent gel-form, use and to have no side effect, not have sense of discomfort, no sense organ residue, selected for use to be usually used in cosmetics and/or excipient substance is an adjuvant, comprised thickening agent or the agent of attached property, wetting agent, acid-base modifier and water.Thickening agent can be selected card wave spectrum series as 940,934, Ultrez-10 for use; For making the effective molding of gel, according to the characteristic of thickening agent, select for use suitable acid-base modifier to make the goods acid-base value suitable and meet thickening agent molding requirement, acid-base modifier can be selected triisopropanolamine, diisopropanolamine (DIPA), triethanolamine for use; Selecting glycerol for use is wetting agent, makes active component that lasting fungistatic effect be arranged.
Preparation method of the present invention is the thickening agent that accurately takes by weighing metering in proportion, swells in the deionized water of respective amount, stirs.Triclosan is dissolved in the ethanol, wetting agent solution of respective amount, adds then in the thickening agent swelling solution, be stirred to evenly; The acid-base neutralization agent that adds respective amount in the mixed solution is stirred to evenly, transparent gel-form.For making gel free from admixture, no particulate matter, goods are sub-packed in the good transparent flexible package of sealing.
The present invention utilizes ethanol and the synergistic activity of triclosan instantaneous sterilization and triclosan to continue the bacteriostatic characteristics according to the good compatibility of triclosan and number of chemical raw material, is developed into to have the disposable gel disinfectant of bacteriostasis efficacy extremely.The present invention is through killing microorganisms experiment and toxicological experiment, prove that it has the good bacteriostasis of killing, rapid-action, longer duration, various toxicology tests, on probation all meet the requirements, be comparatively ideal daily disinfectant products, can be used for sterilization, the sterilization, antibacterial of skin and body surface, the generation of prevention contact infectious disease (for example SARS, hepatitis A, hepatitis B virus, HIV (human immunodeficiency virus) HIV etc.).
When the present invention uses, directly get an amount of this gel, need not water and clean, directly smear and get final product, be applicable to a plurality of age brackets, be particularly useful for travelling, the outdoor activities personnel, as driver and conductor, archaeological work personnel, mountaineer etc.
The specific embodiment
Embodiment 1
Removing in the explanation has special showing, all proportions is mass ratio.By following formulation disinfecting gel.
Deionized water 33.05%
Carbopol (Carbopol)-Ultrez-10 0.30%
Glycerol (glycerol) 1.00%
Ethanol 65.00%
Triclosan 0.10%
Triisopropanolamine 0.45%
Under the room temperature, accurately take by weighing the carbopol-Ultrez-10 of metering in proportion, swell in the deionized water of respective amount, stir.Take by weighing required triclosan, be dissolved in the ethanol, glycerite of respective amount, it is added in the Carbopol swelling solution, be stirred to evenly; The triisopropanolamine that adds respective amount in the mixed solution is stirred to evenly, transparent gel-form.For making gel free from admixture, no particulate matter, goods are sub-packed in the good transparent flexible package of sealing.
The gel of present embodiment preparation escherichia coli, staphylococcus aureus are effectively killed, and bacteriostasis rate can reach 100%.According to GB15979-2002 " disposable use hygienic article sanitary standard ", to escherichia coli (8099) the 6th generation effect 2 minutes, it was 100% that the result shows colibacillary average bacteriostasis rate, sees Table 1 with 1: 1 diluent; Adopt this gel product stock solution, two kinds of import sample stock solutions to carry out the escherichia coli bacteriostatic test, the result proves that it has stronger bacteriostasis; According to GB15979-2002 " disposable use hygienic article sanitary standard ", to staphylococcus aureus (ATCC 6538) the 6th generation effect 2 minutes, the result showed that the average bacteriostasis rate to staphylococcus aureus is 100%, sees Table 2 with 1: 1 diluent; Through the no skin irritation test of zoopery proof, experiment is undertaken by " disinfection technology standard " (version in 2002) skin irritation test regulation, choose the male Japan large ear rabbit of 2.5-3.0kg one-level, carry out acute skin irritation test, test cropping in preceding 24 hours, after checking nothing redness, breakage before the experiment, will be tried thing 0.5ml and evenly be applied in the unhairing district, be sealed 4 hours; Remove with warm water and to be tried behind the thing to observe respectively in 1,24,48 hour dermoreaction, the integral mean value observed of different time is 0 as a result, sees Table 3, proves that this gel product does not have skin irritation.Carry out continuous skin irritation test by " disinfection technology standard " regulation, experiment is prepared the same, and continuous 14 days skin irritation, and record result show that these goods are to the skin nonirritant.
Table 1 pair colibacillary fungistatic effect
| The test sequence number | The bacteriostasis rate (%) of effect different time (min) | |||
| ????2 | ????5 | ????10 | ????20 | |
| 123 is average | ????100.00 ????100.00 ????100.00 ????100.00 | ????100.00 ????100.00 ????100.00 ????100.00 | ????100.00 ????100.00 ????100.00 ????100.00 | ????100.00 ????100.00 ????100.00 ????100.00 |
The fungistatic effect of table 2 pair staphylococcus aureus
| The test sequence number | The bacteriostasis rate (%) of effect different time (min) | |||
| ????2 | ????5 | ????10 | ????20 | |
| 123 is average | ????100.00 ????100.00 ????100.00 ????100.00 | ????100.00 ????100.00 ????100.00 ????100.00 | ????100.00 ????100.00 ????100.00 ????100.00 | ????100.00 ????100.00 ????100.00 ????100.00 |
Table 3 couple Japan large ear rabbit acute skin irritation test result
| Number of animals | Sex | Body weight Kg | ???????????????1h | ???????????????24h | ???????????????48h | |||||||||||||||
| Sample | Contrast | Sample | Contrast | Sample | Contrast | |||||||||||||||
| Erythema | Edema | Total points | Erythema | Edema | Total points | Erythema | Edema | Total points | Erythema | Edema | Total points | Erythema | Edema | Total points | Erythema | Edema | Total points | |||
| 1 | Male | 2. 8 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 |
| 2 | Male | 2. 6 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 |
| 3 | Male | 2. 8 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 |
| 4 | Male | 2. 7 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 | ?0 |
| Integral mean value 0 | ||||||||||||||||||||
| Stimulus intensity classification nonirritant | ||||||||||||||||||||
Embodiment 2
By following formulation disinfecting gel.
Deionized water 28.05%
Carbopol (Carbopol)-Ultrez-10 0.30%
Glycerol (glycerol) 1.00%
Ethanol 70.00%
Triclosan 0.20%
Triisopropanolamine 0.45%
Accurately take by weighing carbopol-Ultrez-10 in proportion, swell in the deionized water of respective amount, slowly stir in the swelling process.Take by weighing required triclosan, be dissolved in the ethanol, glycerite of respective amount, it is added in the Carbopol swelling solution, be stirred to evenly; The triisopropanolamine that adds respective amount in the mixed solution is stirred to evenly, transparent gel-form.
Embodiment 3
By following formulation disinfecting gel.
Deionized water 38.3%
Carbopol 940 0.20%
Glycerol (glycerol) 1.00%
Ethanol 60%
Triclosan 0.20%
Triethanolamine 0.3%
Accurately take by weighing carbopol 940 in proportion, swell in the deionized water of respective amount, stir.Take by weighing required triclosan, be dissolved in the ethanol, glycerite of respective amount, it is added in the Carbopol swelling solution, be stirred to evenly; The triethanolamine that adds respective amount in the mixed solution is stirred to evenly, transparent gel-form.
Claims (8)
1, a kind of disposable disinfecting gel is characterized in that it is main effectively active component with triclosan (2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether), is equipped with to comprise that medical formulation preparation forms.
2, disposable disinfecting gel according to claim 1 is characterized in that it comprises cooperative effect agent, etoh solvent.
3,, it is characterized in that it comprises thickening agent carbopol 934, carbopol 940 or carbopol Ultrez-10 according to the described disposable disinfecting gel of claim 1-2.
4,, it is characterized in that it comprises acid-base modifier triisopropanolamine, triethanolamine or diisopropanolamine (DIPA) according to the described disposable disinfecting gel of claim 1-3.
5,, it is characterized in that it comprises that wetting agent is a glycerol according to the described disposable disinfecting gel of claim 1-4.
6,, it is characterized in that its composition and mass ratio prescription: triclosan 0.05%-0.5%, ethanol 60%-70% according to the described disposable disinfecting gel of claim 1-5, wetting agent 1%-5%, thickening agent 0.1%-0.5%, acid-base modifier 0.2%-0.6%, deionized water 23%-39%.
7, disposable disinfecting gel according to claim 6 is characterized in that its composition and mass ratio prescription: triclosan 0.1%-0.2%, ethanol 60%-70%, wetting agent 1%, thickening agent 0.2%-0.3%, acid-base modifier 0.3%-0.45%, deionized water 23%-39%.
8, the preparation method of the described disposable disinfecting gel of claim 1 is characterized in that it is to comprise the steps: the thickening agent of metering is swollen in the deionized water, stirs; Triclosan is dissolved in ethanol, the wetting agent solution, adds then in the thickening agent swelling solution, be stirred to evenly; In mixed solution, add the acid-base neutralization agent, be stirred to even, transparent gel-form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03130383 CN1265842C (en) | 2003-07-09 | 2003-07-09 | Washing free gel for disinfection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03130383 CN1265842C (en) | 2003-07-09 | 2003-07-09 | Washing free gel for disinfection |
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| Publication Number | Publication Date |
|---|---|
| CN1480221A true CN1480221A (en) | 2004-03-10 |
| CN1265842C CN1265842C (en) | 2006-07-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03130383 Expired - Fee Related CN1265842C (en) | 2003-07-09 | 2003-07-09 | Washing free gel for disinfection |
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| Country | Link |
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| CN (1) | CN1265842C (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100434121C (en) * | 2005-11-18 | 2008-11-19 | 山东大学 | Clothing microbiostatic deodorant |
| CN101912358A (en) * | 2010-08-12 | 2010-12-15 | 江苏爱特福84股份有限公司 | Washing-free hand disinfectant and preparation method |
| CN102210886A (en) * | 2011-06-08 | 2011-10-12 | 湖南恒邦医疗科技有限公司 | Scar removal gel composition and preparation method thereof |
| CN103239429A (en) * | 2013-04-28 | 2013-08-14 | 山东新华医疗器械股份有限公司 | Quick-dry type hand disinfection gel and preparation method thereof |
| CN104547275A (en) * | 2014-12-22 | 2015-04-29 | 合肥天一生物技术研究所 | Hand essential oil skin-care disinfection gel and preparation method thereof |
| CN105055304A (en) * | 2015-08-04 | 2015-11-18 | 河北冀衡化学股份有限公司 | Leave-on skin care and disinfection gel containing composite sterilization component, and preparation method thereof |
| CN105232355A (en) * | 2015-10-19 | 2016-01-13 | 湖北穆兰同大科技有限公司 | No-clean hand lotion and preparation method thereof |
| CN105456054A (en) * | 2016-01-04 | 2016-04-06 | 保洁丽日用品(深圳)有限公司 | Water-free hand sanitizer and preparing method thereof |
| CN108113942A (en) * | 2018-02-02 | 2018-06-05 | 上海哈美实业发展有限公司 | A kind of sterilization non-water hand cleanser and preparation method thereof |
| CN109646375A (en) * | 2019-01-24 | 2019-04-19 | 合肥天生物技术研究所有限责任公司 | A kind of disposable hand-wrist bones gel and preparation method thereof |
| CN110227084A (en) * | 2019-07-04 | 2019-09-13 | 华中科技大学同济医学院附属同济医院 | Medical anti-x-ray radiation disinfecting gel and preparation method thereof |
| CN110859799A (en) * | 2019-12-03 | 2020-03-06 | 武汉康宁美生物科技有限公司 | Antibacterial gel and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997842A (en) * | 2015-08-21 | 2015-10-28 | 南阳市汇博生物技术有限公司 | Anti-bacteria anti-itch gel and preparation method |
-
2003
- 2003-07-09 CN CN 03130383 patent/CN1265842C/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100434121C (en) * | 2005-11-18 | 2008-11-19 | 山东大学 | Clothing microbiostatic deodorant |
| CN101912358A (en) * | 2010-08-12 | 2010-12-15 | 江苏爱特福84股份有限公司 | Washing-free hand disinfectant and preparation method |
| CN102210886A (en) * | 2011-06-08 | 2011-10-12 | 湖南恒邦医疗科技有限公司 | Scar removal gel composition and preparation method thereof |
| CN103239429A (en) * | 2013-04-28 | 2013-08-14 | 山东新华医疗器械股份有限公司 | Quick-dry type hand disinfection gel and preparation method thereof |
| CN104547275A (en) * | 2014-12-22 | 2015-04-29 | 合肥天一生物技术研究所 | Hand essential oil skin-care disinfection gel and preparation method thereof |
| CN105055304A (en) * | 2015-08-04 | 2015-11-18 | 河北冀衡化学股份有限公司 | Leave-on skin care and disinfection gel containing composite sterilization component, and preparation method thereof |
| CN105232355A (en) * | 2015-10-19 | 2016-01-13 | 湖北穆兰同大科技有限公司 | No-clean hand lotion and preparation method thereof |
| CN105456054A (en) * | 2016-01-04 | 2016-04-06 | 保洁丽日用品(深圳)有限公司 | Water-free hand sanitizer and preparing method thereof |
| CN108113942A (en) * | 2018-02-02 | 2018-06-05 | 上海哈美实业发展有限公司 | A kind of sterilization non-water hand cleanser and preparation method thereof |
| CN109646375A (en) * | 2019-01-24 | 2019-04-19 | 合肥天生物技术研究所有限责任公司 | A kind of disposable hand-wrist bones gel and preparation method thereof |
| CN110227084A (en) * | 2019-07-04 | 2019-09-13 | 华中科技大学同济医学院附属同济医院 | Medical anti-x-ray radiation disinfecting gel and preparation method thereof |
| CN110859799A (en) * | 2019-12-03 | 2020-03-06 | 武汉康宁美生物科技有限公司 | Antibacterial gel and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1265842C (en) | 2006-07-26 |
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