CN114796253A - Biological sterilization antiviral composition, sanitary wet tissue and application thereof - Google Patents
Biological sterilization antiviral composition, sanitary wet tissue and application thereof Download PDFInfo
- Publication number
- CN114796253A CN114796253A CN202210353059.3A CN202210353059A CN114796253A CN 114796253 A CN114796253 A CN 114796253A CN 202210353059 A CN202210353059 A CN 202210353059A CN 114796253 A CN114796253 A CN 114796253A
- Authority
- CN
- China
- Prior art keywords
- biological
- antiviral composition
- wet tissue
- polylysine
- epsilon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Abstract
The invention relates to the technical field of biological wet tissues, in particular to a biological bactericidal antiviral composition, a sanitary wet tissue and application thereof. The invention discloses a biological bactericidal antiviral composition taking a natural preservative epsilon-polylysine as a main active ingredient, which can be used for producing biological bactericidal antiviral sanitary wet tissues taking non-woven fabrics, biological cellulose materials or absorbent cotton gauze as a carrier. The biological sterilization antiviral sanitary wet tissue can effectively kill different microorganisms such as gram-positive bacteria, gram-negative bacteria, saccharomycetes, mycete, viruses and the like, has the characteristics of strong sterilization antiviral activity, wide bacteriostasis spectrum, good thermal stability, high safety and no skin irritation, and is particularly suitable for cleaning and disinfecting the surfaces of oral cavities, skins, toys, medical equipment articles and special places of armies and hospitals of sensitive people such as infants, old people, women and the like.
Description
Technical Field
The invention relates to the technical field of biological wet tissues, in particular to a biological bactericidal antiviral composition, a sanitary wet tissue and application thereof.
Background
During daily activities, people can continuously contact various articles, air and the like. These articles and the air may contain pathogenic bacteria, fungi and viruses. With the increasing attention of the public to health, the consumption of the sterilizing and antivirus wet tissue is rapidly increased. The effective active ingredients of the disinfection wet tissue in the current market are 75% ethanol, cetylpyridinium chloride, benzethonium chloride, chlorhexidine gluconate and the like. Wherein the oral LD50 of cetylpyridinium chloride rat is 200 mg/kg. The product is toxic to swallow, and is used without inhalation of dust and contact with skin and eyes. Benzethonium chloride is very irritating and, among the latest edition of the cosmetic specifications in our country, benzethonium chloride is indicated to belong to the limited group of preservatives. 75% ethanol affects skin elasticity, causing dry and rough skin, abundant sebum secretion, and large pores. Chlorhexidine gluconate is not effective against spores, viruses and acid-fast bacteria. The invention discloses an environment-friendly wet tissue for infants and a preparation method thereof (CN110314125A), wherein one or two of sodium lactate and benzalkonium chloride are used as bactericides, but the benzalkonium chloride is ineffective to pseudomonas aeruginosa, acid-fast bacillus and cell spores, and the sodium lactate has a poor sterilization effect under a near-neutral pH. Therefore, there is an urgent technical and market need to develop a composition having good bactericidal and antiviral activities and safety and to produce sterilized wet tissues using the same.
Disclosure of Invention
In view of the above-mentioned problems, it is an object of the present invention to provide a biocidal and antiviral composition.
Another object of the present invention is to provide a sanitary wet towel.
Further, the invention also aims to provide the application of the biological sterilization antiviral composition and the sanitary wet tissue.
Further, the invention provides a preparation method of the biological sterilization antiviral composition and the sanitary wet tissue.
The invention adopts the following technical scheme:
in various embodiments, there is provided a biocidal antiviral composition comprising, in weight percent:
0.01 to 0.1 percent of epsilon-polylysine
0 to 0.05 percent of natamycin
Citric acid according to the need of adjusting pH
The rest components are reverse osmosis pure water.
Further, the sanitary wet tissue carrier can be non-woven fabric or biological cellulose material or absorbent cotton gauze, and more preferably, the sanitary wet tissue carrier is biological cellulose material.
The invention also provides a preparation method of the sanitary wet tissue, which comprises the following steps:
(1) when the biological bactericidal antiviral composition with only epsilon-polylysine as an active ingredient is prepared, the epsilon-polylysine and reverse osmosis pure water are uniformly stirred, the pH value is adjusted to 5.5-6.0 by using 0.1mol/L citric acid solution, and the volume is complemented by using the reverse osmosis pure water to obtain a biological bactericidal antiviral composition I;
(2) when the biological sterilization antiviral composition with the active ingredients of epsilon-polylysine and natamycin is prepared, the epsilon-polylysine and reverse osmosis pure water are uniformly stirred to obtain an epsilon-polylysine solution, the natamycin is dissolved by a citric acid solution with the pH value of 3.0, ultrasonic dispersion is carried out for 5-30 minutes to obtain a natamycin solution, the epsilon-polylysine solution and the natamycin solution are mixed, the pH value is adjusted to 5.5-6.0 by a 0.1mol/L citric acid solution, and the volume is complemented by the reverse osmosis pure water to obtain a biological sterilization antiviral composition II;
(3) soaking a biological cellulose material or a non-woven fabric or a cotton wool gauze sanitary wet tissue carrier in a biological bactericidal antiviral composition I or a biological bactericidal antiviral composition II;
(4) folding the sanitary wet tissue carrier soaked by the biological sterilization antiviral composition in the step (3), sealing and packaging, and sterilizing at high temperature.
Compared with the prior art, the invention has the beneficial effects that:
the epsilon-polylysine is a lysine homopolymer produced by microbial fermentation, can effectively kill different microorganisms such as gram-positive bacteria, gram-negative bacteria, saccharomycetes, mycete, viruses and the like, has good thermal stability, and is approved to be used as a food preservative. Natamycin is a natural product produced by microbial fermentation, is a food grade bactericide with the strongest fungus killing effect, has good safety and thermal stability, and is approved to be used as a food preservative. Citric acid is a natural organic acid produced by microbial fermentation, can be used as an acidity regulator in food according to needs and has certain bactericidal and antiviral biological activities. The food-grade preservative epsilon-polylysine and natamycin are used as biological bactericidal antiviral active ingredients, can effectively kill different microorganisms such as gram-positive bacteria, gram-negative bacteria, saccharomycetes, mycete, viruses and the like, has the good effects of strong bactericidal antiviral activity, wide antibacterial spectrum, good thermal stability, high safety and no skin irritation, and is particularly suitable for sensitive people such as infants, old people, patients, women and the like, and special places such as military, hospitals and the like, and cleaning and disinfection.
The wet tissue prepared by the biological bactericidal antiviral composition II has a better fungus killing effect on skin or objects seriously polluted by mould and yeast.
The carrier has wide application range, can use non-woven fabrics or biological cellulose materials or absorbent cotton gauze, can select different carriers according to different purposes, can be completely degraded when the biological cellulose materials or the absorbent cotton gauze are used as the carriers, and has no environmental pollution.
The biological sterilization and antivirus sanitary wet tissue does not contain a surfactant, essence, a chelating agent, an organic solvent, or a chemical preservative such as cetylpyridinium chloride, benzethonium chloride and chlorhexidine gluconate, and can be used for the sanitary disinfection of various articles such as oral cavities, skin surfaces, toys, medical instruments, tableware, office supplies, leather and the like and places such as military troops, hospitals and the like.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without any inventive step, are within the scope of the present invention.
Example 1:
the biological bactericidal antiviral composition comprises the following components in percentage by weight:
0.01 percent of epsilon-polylysine
0 percent of natamycin
Citric acid according to the need of adjusting pH
The rest components are reverse osmosis pure water.
The biological sterilization antiviral sanitary wet tissue carrier is non-woven fabric.
The preparation method of the biological sterilization antiviral sanitary wet tissue comprises the following steps:
(1) weighing 0.01% of epsilon-polylysine, uniformly stirring the epsilon-polylysine and reverse osmosis pure water, adjusting the pH to 5.8 by using 0.1mol/L citric acid solution, and supplementing the volume by using the reverse osmosis pure water to obtain the biological bactericidal antiviral composition;
(2) soaking the non-woven fabric in the biological bactericidal and antiviral composition;
(3) folding the sanitary wet tissue carrier soaked by the biological sterilization antiviral composition in the step (2), sealing and packaging, and sterilizing at the high temperature of 121 ℃ for 30 minutes to obtain a sanitary wet tissue product 1.
The prepared sanitary wet tissue product 1 is suitable for sanitary cleaning of skin, toys, tableware, medical appliances, office product surfaces, families, hospitals and troops.
Example 2:
the biological bactericidal antiviral composition comprises the following components in percentage by weight:
0.1 percent of epsilon-polylysine
Natamycin 0.05%
Citric acid according to the need of adjusting pH
The rest components are reverse osmosis pure water.
The biological sterilization antiviral sanitary wet tissue carrier is biological cellulose.
The preparation method of the biological sterilization and antivirus sanitary wet tissue comprises the following steps:
(1) weighing 0.1% of epsilon-polylysine, uniformly stirring the epsilon-polylysine and reverse osmosis pure water to obtain an epsilon-polylysine solution, weighing 0.05% of natamycin, dissolving the natamycin by using a citric acid solution with the pH value of 3.0, ultrasonically dispersing for 5 minutes to obtain a natamycin solution, mixing the epsilon-polylysine solution and the natamycin solution, adjusting the pH value to 5.5 by using a citric acid solution with the concentration of 0.1mol/L, and supplementing the volume by using the reverse osmosis pure water to obtain the biological bactericidal and antiviral composition;
(2) soaking the biological cellulose carrier in a biological bactericidal antiviral composition;
(3) folding the sanitary wet tissue carrier soaked by the biological sterilization antiviral composition in the step (2), sealing and packaging, and sterilizing at the high temperature of 121 ℃ for 30 minutes.
The prepared biological sterilization and antivirus sanitary wet tissue product 2 is suitable for the sanitation and cleaning of oral cavity, skin surface, medical apparatus, toy, tableware, leather surface and environment of office, family, hospital and army.
Example 3:
the biological bactericidal antiviral composition comprises the following components in percentage by weight:
0.05 percent of epsilon-polylysine
0.05 percent of natamycin
Citric acid according to the need of adjusting pH
The rest components are reverse osmosis pure water.
The biological sterilization antiviral sanitary wet tissue carrier is non-woven fabric.
The preparation method of the biological sterilization antiviral sanitary wet tissue comprises the following steps:
(1) weighing 0.05% of epsilon-polylysine, uniformly stirring the epsilon-polylysine and reverse osmosis pure water to obtain an epsilon-polylysine solution, weighing 0.05% of natamycin, dissolving the natamycin by using a citric acid solution with the pH value of 3.0, performing ultrasonic dispersion for 30 minutes to obtain a natamycin solution, mixing the epsilon-polylysine solution and the natamycin solution, adjusting the pH value to 5.5 by using a citric acid solution with the concentration of 0.1mol/L, and supplementing the volume by using the reverse osmosis pure water to obtain the biological bactericidal and antiviral composition;
(2) soaking the non-woven fabric carrier in the biological bactericidal and antiviral composition;
(3) folding the sanitary wet tissue carrier soaked by the biological sterilization antiviral composition in the step (2), sealing and packaging, and sterilizing at the high temperature of 121 ℃ for 30 minutes.
The prepared biological sterilization antiviral sanitary wet tissue product 3 is suitable for sanitary cleaning of skin surfaces, leather, office supplies and household environments with serious fungal pollution.
Example 4:
the biological bactericidal antiviral composition comprises the following components in percentage by weight:
0.1 percent of epsilon-polylysine
Natamycin 0%
Citric acid according to the need of adjusting pH
The rest components are reverse osmosis pure water.
The carrier of the biological sterilization antiviral sanitary wet tissue is absorbent cotton gauze.
The preparation method of the sanitary wet tissue comprises the following steps:
(1) weighing 0.1% of epsilon-polylysine, uniformly stirring the epsilon-polylysine and reverse osmosis pure water, adjusting the pH to 6.0 by using 0.1mol/L citric acid solution, and supplementing the volume by using the reverse osmosis pure water to obtain the biological bactericidal antiviral composition;
(2) soaking absorbent cotton gauze in the biological bactericidal and antiviral composition;
(3) folding the sanitary wet tissue carrier soaked by the biological sterilization antiviral composition in the step (2), sealing and packaging, and sterilizing at the high temperature of 121 ℃ for 30 minutes to obtain a sanitary wet tissue product 4.
The prepared biological sterilization antiviral sanitary wet tissue product 4 is suitable for the sanitary disinfection of the oral cavity and the skin surface with less fungal pollution, the surfaces of toys, medical instruments and pH sensitive articles and the military and hospital places.
And (3) product performance testing: and (3) determining the bactericidal rate according to an antibacterial and bacteriostatic effect evaluation method WS/T650-2019 and a textile antiviral activity determination ISO 18184: 2019. Skin irritation test was performed according to "guidelines for evaluating the efficacy of cosmetics".
Comparative example 1: sanitary wet towel with 75% ethanol as active component and non-woven fabric as carrier
Comparative example 2: sanitary wet tissue with chlorhexidine gluconate as active ingredient and non-woven fabric as carrier
The product performance test shows that the sanitary wet tissue has good killing effect on gram-positive bacteria, gram-negative bacteria, fungi and viruses, has no irritation and has outstanding technical advantages.
Claims (6)
1. A biological sterilization antiviral composition is characterized in that: the biological bactericidal antiviral composition comprises the following components in percentage by weight: 0.01-0.1% of epsilon-polylysine, 0-0.05% of natamycin, citrate according to the requirement of pH adjustment, and the balance of reverse osmosis pure water.
2. The biocidal and antiviral composition of claim 1, wherein: the biological sterilization antiviral composition does not contain alcohols, chlorides, quaternary ammonium salts, peroxides, phenolic disinfectants, surfactants, chelating agents, organic solvents and essences.
3. A biological sterilization antiviral sanitary wet tissue is characterized in that: the carrier may be a non-woven or bio-cellulosic material or absorbent cotton gauze.
4. The biological bactericidal antiviral sanitary wet wipe as set forth in claim 3, characterized in that: a biocidal and antiviral composition comprising the composition of claim 1.
5. The preparation method of the biological sterilization and antivirus sanitary wet tissue is characterized in that: the method comprises the following steps:
(1) when the biological bactericidal antiviral composition with only epsilon-polylysine as an active ingredient is prepared, the epsilon-polylysine and reverse osmosis pure water are uniformly stirred, the pH value is adjusted to 5.5-6.0 by using 0.1mol/L citric acid solution, and the volume is complemented by using the reverse osmosis pure water to obtain a biological bactericidal antiviral composition I;
(2) when the biological sterilization antiviral composition with the active ingredients of epsilon-polylysine and natamycin is prepared, the epsilon-polylysine and reverse osmosis pure water are uniformly stirred to obtain an epsilon-polylysine solution, the natamycin is dissolved by a citric acid solution with the pH value of 3.0, ultrasonic dispersion is carried out for 5-30 minutes to obtain a natamycin solution, the epsilon-polylysine solution and the natamycin solution are mixed, the pH value is adjusted to 5.5-6.0 by a 0.1mol/L citric acid solution, and the volume is complemented by the reverse osmosis pure water to obtain a biological sterilization antiviral composition II;
(3) soaking a biological cellulose material or a non-woven fabric or a cotton wool gauze sanitary wet tissue carrier in a biological bactericidal antiviral composition I or a biological bactericidal antiviral composition II;
(4) folding the sanitary wet tissue carrier soaked by the biological sterilization antiviral composition in the step (3), sealing and packaging, and sterilizing at high temperature.
6. The biological sterilization antiviral sanitary wet tissue is characterized in that: the biological sterilization and antivirus sanitary wet tissue is used for the sanitary disinfection of oral cavities, skins, toys, medical instruments, tableware, office supplies, surfaces of leather products, military troops and hospital places.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210353059.3A CN114796253A (en) | 2022-04-06 | 2022-04-06 | Biological sterilization antiviral composition, sanitary wet tissue and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210353059.3A CN114796253A (en) | 2022-04-06 | 2022-04-06 | Biological sterilization antiviral composition, sanitary wet tissue and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114796253A true CN114796253A (en) | 2022-07-29 |
Family
ID=82532539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210353059.3A Pending CN114796253A (en) | 2022-04-06 | 2022-04-06 | Biological sterilization antiviral composition, sanitary wet tissue and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114796253A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115778849A (en) * | 2022-12-19 | 2023-03-14 | 江苏百赛飞生物科技有限公司 | Antibacterial wet tissue capable of being used for cleaning hands and mouths of infants |
-
2022
- 2022-04-06 CN CN202210353059.3A patent/CN114796253A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115778849A (en) * | 2022-12-19 | 2023-03-14 | 江苏百赛飞生物科技有限公司 | Antibacterial wet tissue capable of being used for cleaning hands and mouths of infants |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109381480B (en) | Compound polyhexamethylene biguanide disinfectant and preparation method thereof | |
| US6262038B1 (en) | Germicidal composition | |
| KR101555341B1 (en) | Antibiotic wet tissue, and manufacturing method thereof | |
| CN101766552A (en) | Washing-free antibacterial hand sanitizer and preparation method thereof | |
| CN108186403A (en) | A kind of impregnated wipe and preparation method thereof | |
| CN101658397A (en) | Functional wipes containing chlorine dioxide and application thereof | |
| CN102894001A (en) | Antiseptic and mildew inhibitor composition for wet tissues and production method thereof | |
| CN109125096A (en) | Foam liquid soap and preparation method thereof | |
| CN104622716A (en) | Medical nursing wet tissue which is non-alcoholic, long-acting, antibacterial and capable of removing dirt and disinfectant | |
| CN101766186A (en) | Composition capable of slowly-releasing chlorine dioxide and application thereof | |
| CN101336637B (en) | Complex type broad-spectrum disinfectant and use thereof | |
| CN114796253A (en) | Biological sterilization antiviral composition, sanitary wet tissue and application thereof | |
| CN1265842C (en) | Washing free gel for disinfection | |
| JP3187676B2 (en) | Antibacterial wiper | |
| JPH0759482B2 (en) | Disinfectant | |
| CN111418587A (en) | Efficient household fabric disinfectant and preparation method thereof | |
| CN108498343A (en) | A kind of degreasing wet tissue and preparation method thereof | |
| JPH072615A (en) | Cloth impregnated with antimicrobial disinfectant | |
| KR101476093B1 (en) | A composition for water tissue containing Piroctone olamine | |
| CN1063610C (en) | Broad-spectrum fungicide | |
| KR20070071337A (en) | Wet tissue product having a good antimicrobial property | |
| CN111773157B (en) | Wet tissue and preparation method thereof | |
| KR102267156B1 (en) | (Composition for sterilization or disinfection and manufacturing method thereof | |
| CN106137800A (en) | Eucalyptus oil pasteurization towelette and preparation method thereof | |
| US20040253139A1 (en) | Environmental surface disinfectant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication |