CN101537000A - Multi-purpose disinfectant - Google Patents
Multi-purpose disinfectant Download PDFInfo
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- CN101537000A CN101537000A CN200810102042A CN200810102042A CN101537000A CN 101537000 A CN101537000 A CN 101537000A CN 200810102042 A CN200810102042 A CN 200810102042A CN 200810102042 A CN200810102042 A CN 200810102042A CN 101537000 A CN101537000 A CN 101537000A
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- disinfectant
- skin
- chlorhexidine
- quaternary ammonium
- ammonium salt
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Abstract
The invention provides a multi-purpose disinfectant, which is mainly applied to skin, surfaces of the wound and mucous membranes, surfaces of common articles and textile, and the like. The disinfectant consists of the following raw materials: single and double chain compound quaternary ammonium salt, chlorhexidine acetat(or chlorhexidine gluconate) and proper amount of synergistic agent and distilled water. The disinfectant can quickly kill enteric bacilli, suppurative bacilli, yeast bacteria, hospital infection common bacteria, and all known common bacteria, and is widely applied to fields in medical treatment, industry, civilian use and the like.
Description
Technical field
What the present invention relates to is a kind of new disinfectant, what be particularly related to is that a kind of medical personnel of being applicable to sterilize in diagnosis and treatment front and back, operation, notes are used for skin degerming and debridement treatment and mucosa when defeated nursing, also can be used for general body surface and fabric, is the disinfectant of the splendid selection of cleaning-nursing of new generation.
Background technology
The common feature of the skin of the regular use that present domestic medical system is a large amount of and other disinfectant in field (iodine tincture, povidone iodine, povidone iodine, ethanol, normal propyl alcohol and isopropyl alcohol, glutaraldehyde etc.) is: zest is strong, dyeing obviously, toxicity is big, taste is unfriendly, contaminated environment, purposes are single.
Summary of the invention
The pluses and minuses that the objective of the invention is comprehensive domestic and international various like products, overcome above deficiency, the double-stranded compound quaternary ammonium salt of list of employing U.S. FDA and U.S. public health bureau double authentication and chlorhexidine acetate (or chlorhexidine gluconate) and extraordinary synergist carry out composite, have developed the novel high-efficiency environment friendly disinfectant solution.That this invention can be satisfied fully is pollution-free, non-stimulated, efficient, nontoxic, taste is friendly, be widely used, be convenient to each conditions such as transportation, and whole specification requirements of health ministry (disinfection technology standard version in 2002).The soft iodine that do not contain of the present invention, nontoxic non-stimulated, adopt the environment-friendly materials preparation, be applicable to all clinical departments of hospital and industry, each field such as civilian.
The object of the present invention is achieved like this:
Skin of the present invention, wound surface and mucosa, general body surface, the agent of fabric multipurpose disinfection.Form by following component by weight percentage:
Single double-stranded compound quaternary ammonium salt 0.1-0.3%
Chlorhexidine acetate (or chlorhexidine gluconate) 0.1-0.3%
Synergist is an amount of
Distilled water surplus
Chlorhexidine acetate in the above-mentioned component (or chlorhexidine gluconate) plays bactericidal action energy kill bacteria, fungus, and all antibacterials, fungus that single double-stranded compound quaternary ammonium salt not only can be killed except that spore also can all known viruses of deactivation.Reach above the ordinary bactericidal effect after above-mentioned two components and extraordinary synergist are composite, skin, wound surface and mucosa sterilization only need 1 minute, and general body surface and fabric only need 3 minutes.Distilled water plays diluting effect.
Disinfectant of the present invention detects (accepting numbering 200516) through sterilization inspection center of Military Medical Science Institute, detects conclusion:
Quaternary ammonium salt active matter average content in the disinfectant solution sample stock solution is 1774mg/L, and scope is 1765-1783mg/L.37 ℃ of constant temperature were preserved after 3 months, and quaternary ammonium salt active matter average content is 1769mg/L, and scope is 1762-1773mg/L.With preserve before compare, the rate of descent scope is 0.00-0.56%.
Chlorhexidine acetate average content in the disinfectant solution sample stock solution is 1828mg/L, and scope is 1824-1832mg/L.After 37 ℃ of constant temperature were preserved 3 months, the chlorhexidine acetate average content was 1796mg/L, and scope is 1786-1811mg/L.With preserve before compare, the rate of descent scope is 1.14-2.08%.
Disinfectant solution stock solution pH value scope is 6.65-6.77.
Disinfectant solution stock solution is not have corrosion substantially to the corrosion rate of rustless steel, copper, three kinds of sheet metals of aluminum, and Corrosion rate in Carbon Steel is belonged to mild corrosion.
With in and the filtration and washing method can remove residual disinfectancy liquid, and the growth of staphylococcus aureus and Candida albicans is not had influence substantially.
Disinfectant solution stock solution effect 0.5min, staphylococcus aureus on average killed logarithm value＞5.00, to colibacillary logarithm value＞5.00 of on average killing, to Pseudomonas aeruginosa on average kill logarithm value＞5.00, to oidiomycetic logarithm value＞4.00 of on average killing of white.
Disinfectant solution stock solution effect 3min on average kills logarithm value＞1.00 to the natural bacteria of fabric face, and the natural bacteria of body surface is on average killed logarithm value＞1.00.Stock solution effect 1.0min on average kills logarithm value＞1.00 to the natural bacteria of skin surface.
Acute oral toxicity test: disinfectant solution stock solution per os contamination mice LD
50＞5000mg/kg, the true border of toxicity grading is nontoxic.
A damaged skin irritant test: disinfectant solution stock solution acts on the rabbit damaged skin, and integral mean is up to 1, skin irritation index＜2.0, and stimulus intensity belongs to slight the stimulation.
Intact skin irritant test repeatedly: disinfectant solution stock solution acts on rabbit skin, and continuous 14 days, every day, every animal average integral was 1, skin irritation index＜2.0, and stimulus intensity belongs to slight the stimulation.
Vaginal mucomembranous irritant test: disinfectant solution stock solution is 1.9 to the stimulation index of rabbit vagina mucosa, and stimulus intensity belongs to utmost point subexcite.
Acute eye irritation test: the acute eye irritation score index of disinfectant solution stock solution is up to 0, and stimulus intensity belongs to nonirritant.
The PCEMNR micronucleus test: disinfectant solution stock solution does not have the micronucleus of causing effect to PCEMNR.
Subacute toxicity test: maximum is not observed illeffects dosage (NOAEL) and is the 1000mg/kg body weight.
Disinfectant Disinfection Effect of the present invention is good, and zest is little, is widely used.
The scope of application and method:
A, health care (seeing the following form)
B, commercial production: the hand disinfection that can be used for the personnel of sterile working of industrial undertaking such as pharmacy, food, beverage, drinking-water.
C, daily life: at home, travel, school, service trade, entertainment place personnel's hand and the sterilization of medicated clothing fabric.
D, health treatment for adults: prevention of STD, acquired immune deficiency syndrome (AIDS), be used for sterilization before and after the sexual life; Women's daily nursing.
E, environment disinfected: the disinfection that is applicable to the ground, body of wall, space, object etc. of public places such as hospital, school, hotel, hotel, kindergarten, arenas; Also be applicable to the disinfection on the ground, space, body surface etc. of the vehicles such as aircraft, steamer, train, bus, dispelling abnormal flavor, pure and fresh environment; Can be used for equipment, the Factory Building of food industry, medical industry, electronics industry, aquaculture etc., the disinfection of animal house.Also can be used for the water surface sterilization in aquaculture place, be used for the cleaning-sterilizing of gourd, fruit and vegetable.
The specific embodiment:
The embodiment of the invention sees the following form:
The technology of preparation the various embodiments described above disinfectant is as follows:
1, getting synergist adds in the chlorhexidine acetate (or chlorhexidine gluconate) 20-25 ℃ of stirring 30 minutes;
2, adding single double-stranded compound quaternary ammonium salt stirred 30 minutes at 20-25 ℃;
3, adding distilled water stirred 60 minutes at 20-25 ℃;
4, leave standstill, filtration, fill, decals, coding, packing, finished product warehouse-in.
Claims (3)
1, a kind of multi-purpose disinfectant, be mainly used in aspects such as skin, wound surface and mucosa, general body surface, fabric, it is characterized in that it is that other adds the preparation that material combinations such as an amount of synergist and distilled water surplus are formed by single double-stranded compound quaternary ammonium salt, chlorhexidine acetate (or chlorhexidine gluconate).
2, according to the multi-purpose disinfectant that is mainly used in aspects such as skin, wound surface and mucosa, general body surface, fabric under the claim 1, it is characterized in that it is the preparation of being made by the following weight proportion raw material: single double-stranded compound quaternary ammonium salt, 0.1-0.3%, chlorhexidine acetate (or chlorhexidine gluconate), 0.1-0.3%, synergist is an amount of, the PH balance factor is an amount of, and surplus is a distilled water.
3, according to the multi-purpose disinfectant that is mainly used in aspects such as skin, wound surface and mucosa, general body surface, fabric under claim 1 or 2, it is characterized in that the preparation that it is made by modes such as raw material " stir, leaves standstill, filters ".
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810102042A CN101537000A (en) | 2008-03-17 | 2008-03-17 | Multi-purpose disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810102042A CN101537000A (en) | 2008-03-17 | 2008-03-17 | Multi-purpose disinfectant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101537000A true CN101537000A (en) | 2009-09-23 |
Family
ID=41120543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810102042A Pending CN101537000A (en) | 2008-03-17 | 2008-03-17 | Multi-purpose disinfectant |
Country Status (1)
| Country | Link |
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| CN (1) | CN101537000A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2474017A (en) * | 2009-09-29 | 2011-04-06 | Europ First Aid Ltd | Biocidal solution |
| CN103704241A (en) * | 2013-12-23 | 2014-04-09 | 杭州美克恒辉实业有限公司 | Chlorhexidine gluconate ethanol disinfection solution and production method as well as disinfection cotton swab and disinfection cotton piece |
| CN103830271A (en) * | 2014-02-22 | 2014-06-04 | 武汉药谷生物工程有限公司 | Disinfectant composition and application thereof |
| CN104739664A (en) * | 2013-12-26 | 2015-07-01 | 上海利康消毒高科技有限公司 | Chlorhexidine gluconate bath disinfection liquid and preparation method thereof |
| CN110205210A (en) * | 2019-05-31 | 2019-09-06 | 广东润和新材料科技有限公司 | One kind being used for aircraft passenger compartment disinfection cleaning agent |
-
2008
- 2008-03-17 CN CN200810102042A patent/CN101537000A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2474017A (en) * | 2009-09-29 | 2011-04-06 | Europ First Aid Ltd | Biocidal solution |
| GB2474017B (en) * | 2009-09-29 | 2015-07-15 | Europ First Aid Ltd | Biocidal solution |
| CN103704241A (en) * | 2013-12-23 | 2014-04-09 | 杭州美克恒辉实业有限公司 | Chlorhexidine gluconate ethanol disinfection solution and production method as well as disinfection cotton swab and disinfection cotton piece |
| CN103704241B (en) * | 2013-12-23 | 2016-01-20 | 杭州美克恒辉实业有限公司 | Chlorhexidine gluconate alcohol thimerosal, manufacture method and disinfecting cotton swab, cotton piece |
| CN104739664A (en) * | 2013-12-26 | 2015-07-01 | 上海利康消毒高科技有限公司 | Chlorhexidine gluconate bath disinfection liquid and preparation method thereof |
| CN103830271A (en) * | 2014-02-22 | 2014-06-04 | 武汉药谷生物工程有限公司 | Disinfectant composition and application thereof |
| CN110205210A (en) * | 2019-05-31 | 2019-09-06 | 广东润和新材料科技有限公司 | One kind being used for aircraft passenger compartment disinfection cleaning agent |
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090923 |