CN103704241B - Chlorhexidine gluconate alcohol thimerosal, manufacture method and disinfecting cotton swab, cotton piece - Google Patents
Chlorhexidine gluconate alcohol thimerosal, manufacture method and disinfecting cotton swab, cotton piece Download PDFInfo
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- CN103704241B CN103704241B CN201310719533.0A CN201310719533A CN103704241B CN 103704241 B CN103704241 B CN 103704241B CN 201310719533 A CN201310719533 A CN 201310719533A CN 103704241 B CN103704241 B CN 103704241B
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Abstract
The invention provides a kind of chlorhexidine gluconate alcohol thimerosal, manufacture method and disinfecting cotton swab, cotton piece.Chlorhexidine gluconate, volume fraction that chlorhexidine gluconate alcohol thimerosal is 1.8% ~ 2.2% by volume fraction be 63% ~ 77% ethanol, surplus be that deionized water forms.The present invention adopts the chlorhexidine gluconate of designated volume mark and the mixed solution of ethanol to make thimerosal, compares ethanolic solution and has quick and durable bactericidal effect.Meet pollution-free, non-stimulated, efficient, nontoxic, taste is friendly, be widely used, be convenient to each conditions such as transport.Chlorhexidine gluconate alcohol disinfecting cotton swab provided by the invention or cotton piece, adopt the chlorhexidine gluconate alcohol thimerosal of specific components to infiltrate, can realize quick and durable bactericidal effect.
Description
Technical field
The present invention relates to a kind of thimerosal and disinfector, particularly relate to a kind of chlorhexidine gluconate alcohol thimerosal, manufacture method and disinfecting cotton swab, cotton piece.
Background technology
The skin of the regular use that current domestic medical system is a large amount of and other disinfectant in field, the such as tincture of iodine, Iodophor, povidone iodine etc., but the most excitant of existing disinfectant is strong, dyeing is obvious, toxicity is large, taste is unfriendly, contaminated environment, purposes are single.And can not eliminate the bacterium and most virus that grow up hill and dale, there is antibacterial effect remarkable, the unconspicuous defect of lasting effect, during flushing, user easily feels obvious shouting pain.
In existing disinfectant, ethanol belongs to middle effect disinfectants, and its bactericidal action is very fast, Disinfection Effect is reliable, little to people's excitant, is usually used in the sterilization of skin degerming and clinical treatment apparatus.Ethanol can kill vegetative forms of bacteria rapidly, volume fraction be 40 ~ 60% ethanol the most effective to staphylococcus, but effect is slowly.Volume fraction be 60 ~ 75% ethanol effect 5min can kill the bacterial propagule comprising bacillus, and to micrococcus scarlatinae, gonococcus, typhoid bacillus and Pseudomonas aeruginosa, then can to kill in 1 minute.Ethanol is when higher volume fraction (> 80%), and have (comprising picornavirus and hepatitis B) effect of well killing the virus, inactivation of viruses generally needs 3 ~ 10min.Ethanol has suppression and killing action to fungi, and volume fraction killing fungus action effect in 70% ~ 90% scope is better, and killing fungus spore needs longer action time, general 30 ~ 60min.Ethanol can make protein denaturation, if but the volume fraction of ethanol is too high, make the protein coagulating of bacterium surface on the contrary at once; result forms one deck dura mater; this layer of dura mater has protective effect to bacterium, prevents ethanol from infiltrating further, so the bactericidal effect of dense ethanol is bad on the contrary.
But due to the volatile characteristic of ethanol, just volatilization is complete in one minute for usually ethanol, thus can not guarantee validity and the continuation of sterilization.
The cotton head that cotton swab is made up of medical absorbent cotton and cotton swab bar process.Cotton head water imbibition is strong, after inhaling full thimerosal, by uniform for thimerosal wiping on skin, can reach Disinfection Effect, is applicable to the skin degerming before injecting or surgical dressing.Existing medical cotton stick could use after cotton head need dip thimerosal in use, and thimerosal is generally bottled, inefficacy of easily volatilizing behind Kaifeng, repeatedly dipped and be vulnerable to pollute, and thimerosal easily spills problem when carrying, and carries inconvenience.
In addition, existing cotton swab produce time for convenience of user use and cost-saving, usually two of cotton swab bar is all arranged cotton head.But when reality uses, because the cotton head at two ends cannot be separated, after the cotton head of one end uses, cotton swab is contaminated can not be preserved again again.This will make the cotton head availability of the other end very low, thus causes waste.
Summary of the invention
The present invention, in order to overcome the deficiencies in the prior art, provides a kind of sterilizing effective fast, the chlorhexidine gluconate alcohol thimerosal that lasting effect is strong, manufacture method and disinfecting cotton swab, cotton piece easy to use, bactericidal effect is good.
In order to realize an object of the present invention, the invention provides a kind of chlorhexidine gluconate alcohol thimerosal, is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, and volume fraction is the ethanol of 63% ~ 77%, and surplus is deionized water composition.
In one embodiment of the invention, chlorhexidine gluconate alcohol thimerosal is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, and volume fraction is the ethanol of 75%, and surplus is deionized water composition.
In order to realize another object of the present invention, the present invention also provides a kind of manufacture method of chlorhexidine gluconate alcohol thimerosal, comprise the steps: that according to volume fraction be the chlorhexidine gluconate of 1.8% ~ 2.2%, volume fraction is the ethanol of 75%, surplus is that three kinds of solution mix by the ratio of deionized water, adopts the speed of 1250r/min to be uniformly mixed solution 2 minutes at normal temperatures with magnetic stirring apparatus.
In order to realize another object of the present invention, the present invention also provides a kind of chlorhexidine gluconate alcohol disinfecting cotton swab, comprises plastics cotton swab bar and two cotton heads.Plastics cotton swab bar have sidewall, blind end, openend and by sidewall, blind end, openend around the cavity formed.Blind end adopts heat sealing, and openend adopts silicone oil fluid-tight.Sidewall has snap slot, and the distance between snap slot and blind end is less than 1/5th of the length of described sidewall.Cavity is equipped with chlorhexidine gluconate alcohol thimerosal, and the volume of chlorhexidine gluconate alcohol thimerosal is 4/5ths of the volume of cavity.Chlorhexidine gluconate alcohol thimerosal is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, and volume fraction is the ethanol of 63% ~ 77%, and surplus is deionized water composition.Two cotton heads are wrapped in blind end and the openend of plastics cotton swab bar respectively.
In one embodiment of the invention, two cotton heads have different shapes, and the cotton head of open end is helical form, and the cotton head at blind end place is sharp mouth calabash shaped.
In one embodiment of the invention, the outside of sidewall is coated with tag line in snap slot place.
In one embodiment of the invention, plastics cotton swab bar is polypropylene plastics cotton swab bar, and cotton head is medical absorbent cotton and the cotton head of blind end is color cotton.
In one embodiment of the invention, chlorhexidine gluconate alcohol thimerosal is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, and volume fraction is the ethanol of 75%, and surplus is deionized water composition.
In order to realize another object of the present invention, the present invention also provides a kind of chlorhexidine gluconate alcohol sterilized cotton piece, comprises cotton piece body.Cotton piece body is fully infiltrated by chlorhexidine gluconate alcohol thimerosal.Chlorhexidine gluconate alcohol thimerosal is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, and volume fraction is the ethanol of 63% ~ 77%, and surplus is deionized water composition.
In sum, the present invention adopts the chlorhexidine gluconate of designated volume mark and the mixed solution of ethanol to make thimerosal, compares ethanolic solution and has quick and durable bactericidal effect.Meet pollution-free, non-stimulated, efficient, nontoxic, taste is friendly, be widely used, be convenient to each conditions such as transport.The manufacture method of chlorhexidine gluconate alcohol thimerosal provided by the invention, specific rotating speed is adopted to stir the specific time to the mixed solution of special ratios, make ethanol when consume of volatilizing is low, fully and chlorhexidine gluconate mix, thus play the synergy of sterilization.Chlorhexidine gluconate alcohol disinfecting cotton swab provided by the invention or cotton piece, adopt the chlorhexidine gluconate alcohol thimerosal of specific components to infiltrate, can realize quick and durable bactericidal effect.
In addition, the plastics cotton swab bar due to chlorhexidine gluconate alcohol disinfecting cotton swab is the hollow structure with blind end, and chlorhexidine gluconate alcohol thimerosal can leave in cavity, therefore thimerosal storage and carry convenient, health.Simultaneously, make plastics cotton swab bar broken by arranging snap slot, after plastics cotton swab bar fractures by user, chlorhexidine gluconate alcohol thimerosal can flow to the cotton head of open end gradually, can be used for the skin degerming before injecting or surgical dressing after cotton head is fully infiltrated.Therefore, the sterilization of cotton swab uses convenient, health.And the cotton head at blind end place can be used for injecting rear hemostasis or again depositing, use convenient, pollution-free and any waste can not be caused.By snap slot is located at specific position, chlorhexidine gluconate alcohol thimerosal is ensured, and q.s is with while infiltrating cotton head, the use of the cotton head of convenient and dry again.
For above and other objects of the present invention, feature and advantage can be become apparent, preferred embodiment cited below particularly, is described in detail below.
Accompanying drawing explanation
The schematic diagram of the chlorhexidine gluconate alcohol disinfecting cotton swab provided according to a first embodiment of the present invention is provided.
The cutaway view of the chlorhexidine gluconate alcohol disinfecting cotton swab provided according to a first embodiment of the present invention is provided.
The cutaway view of the chlorhexidine gluconate alcohol disinfecting cotton swab provided according to a second embodiment of the present invention is provided.
Figure 4 shows that the schematic diagram of chlorhexidine gluconate alcohol sterilized cotton piece provided by the invention.
Embodiment
The invention provides a kind of chlorhexidine gluconate alcohol thimerosal, is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, and volume fraction is the ethanol of 63% ~ 77%, and surplus is deionized water composition.
The present invention adopts the chlorhexidine gluconate of designated volume mark and the mixed solution of ethanol to make thimerosal.The bactericidal action of ethanol is because they are to the deformability of protein, and to the excellent effect of gram-positive bacteria, Gram-negative bacteria, some drug-fast bacterias, various fungi, its effect rapidly, and can make the speed that on skin, bacterium regrows decline.Chlorhexidine gluconate can destroy the cell wall of bacterium, causes the irreversible leakage of composition in cell membrane, thus kill bacteria.The quick sterilization effect of chlorhexidine gluconate is slower than ethanol, but its lasting bactericidal action is better than ethanol, and it has suitable continuation (residue attachment) on skin, also absorb without complete skin, thus toxicity is very little.Therefore both share, and both can expand bacterium spectrum, can obtain quick and durable bactericidal effect again.
Use ethanol in product, not only play synergistic function with chlorhexidine gluconate, and there is after embrocating the feature of rapid-curing cutback, substantially reduce the operating time.Ethanol also plays dissolution to chlorhexidine gluconate simultaneously.By using the mixed solution of chlorhexidine gluconate and ethanol instead of all adopting ethanol, reduce the volatility of thimerosal, improve stability and the sterilizing persistence of thimerosal.
Thimerosal of the present invention detects (No. 201301078th, Zhejiang (province) disease control searching) through Zhejiang Center For Disease Control and Prevention, the chlorhexidine gluconate alcohol thimerosal detected, lot number is that this lot number of 0102220130415(comprises five bottles of chlorhexidine gluconate alcohol thimerosals, every bottle of 100ml, five bottles of corresponding components are respectively: the volume fraction of chlorhexidine gluconate is 1.8%, the volume fraction of ethanol is 63%, and the volume fraction of deionized water is 35.2%; The volume fraction of chlorhexidine gluconate is 1.9%, and the volume fraction of ethanol is 75%, and the volume fraction of deionized water is 23.1%; The volume fraction of chlorhexidine gluconate is 2.0%, and the volume fraction of ethanol is 75%, and the volume fraction of deionized water is 23.0%; The volume fraction of chlorhexidine gluconate is 2.1%, and the volume fraction of ethanol is 75%, and the volume fraction of deionized water is 22.9%; The volume fraction of chlorhexidine gluconate is 2.2%, and the volume fraction of ethanol is 77%, and the volume fraction of deionized water is 20.8%).Detection experiment is as follows:
To the sterilize experiment of Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa
One, equipment
1. test strain: Escherichia coli 8099, staphylococcus aureus ATCC6538, pseudomonas aeruginosa ATCC15422, China Microbiological kind preservation administration committee's common micro-organisms center provides, the 5th, 6 generation slant culture.
2. neutralizer 1: containing the TPS of 1% lecithin, 10% Tween-80.
3. neutralizer 2: containing the TPS of 0.12% lecithin, 1.2% Tween-80.
4. thimerosal: chlorhexidine gluconate alcohol thimerosal, lot number 0102220130415.
Two, method
1. test basis: neutralizer approval test, quantitative disinfecting test are by Ministry of Public Health's " disinfection technology standard " (version in 2002) 2.1.1.5.5 bar, 2.1.1.7.4 bar.
2. neutralizer approval test: with 8 times of dilutions of neutralizer 1 and sample stoste, neutralizer 2 and sample respectively with Escherichia coli effect 0.5min, experimental enviroment temperature 20 DEG C, test repetition 3 times.
3. bactericidal assay: to contain the effect of sample stoste, experimental enviroment temperature 20 DEG C, test repetition 3 times.
Three, result
To the killing effect of test organisms
Note: the equal asepsis growth of each negative control
Four, conclusion:
1. the neutralizer containing the TPS of 1.0% lecithin, 10% Tween-80 is applicable to this thimerosal to the quantitative sterilize experiment of Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and the result for spot disinfection test through qualification.
2. show through 3 repeated tests, under 20 DEG C of conditions, this thimerosal effect 0.5min, to the kill oncomelania >5.00 of the Escherichia coli in suspension, staphylococcus aureus, pseudomonas aeruginosa.
To the sterilize experiment of Candida albicans
One, equipment
1. test strain: Candida albicans ATCC10231, China Microbiological kind preservation administration committee's common micro-organisms center provides, the 5th, 6 generation slant culture.
2. neutralizer 1: containing the TPS of 1% lecithin, 10% Tween-80.
3. neutralizer 3: containing the TPS of 0.25% lecithin, 2.5% Tween-80.
4. thimerosal: chlorhexidine gluconate alcohol thimerosal, lot number 0102220130415.
Two, method
1. test basis: neutralizer approval test, quantitative disinfecting test are by Ministry of Public Health's " disinfection technology standard " (version in 2002) 2.1.1.5.5 bar, 2.1.1.9 bar.
2. neutralizer approval test: with 4 times of dilutions of neutralizer 1 and sample stoste, neutralizer 3 and sample respectively with Candida albicans effect 0.5min, experimental enviroment temperature 20 DEG C, test repetition 3 times.
3. bactericidal assay: with the effect of sample stoste, experimental enviroment temperature 20 DEG C, test repetition 3 times.
Three, result
To the killing effect of test organisms
Note: the equal asepsis growth of each negative control
Four, conclusion:
1. the neutralizer containing the TPS of 1.0% lecithin, 10% Tween-80 is applicable to the quantitative sterilize experiment of this thimerosal to Candida albicans through qualification.
2. show through 3 repeated tests, under 20 DEG C of conditions, this thimerosal effect 0.5min, to the kill oncomelania >5.00 of the Candida albicans in suspension.
According to above-mentioned detection experiment result, thimerosal provided by the invention has above the ordinary bactericidal effect, only need to act on 0.5min, the average kill oncomelania >5.00 of the time of Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, Candida albicans.
Detection experiment of the same type finds, be the ethanol of 75% containing volume fraction, volume fraction is the chlorhexidine gluconate of 1.8% ~ 2.2%, and surplus is that the chlorhexidine gluconate alcohol thimerosal bactericidal effect of deionized water composition is best.
Why ethanol can sterilize is because ethanol can absorb the moisture of bacterioprotein, its sex change of dewatering is solidified, thus reaches the object of kill bacteria.If use high concentration ethanol, too rapid to bacterioprotein dehydration, make bacterial surface protein first sex change solidify, define the coating that one deck is firm, ethanol can not infiltrate bacterium inside on the contrary well, so that affects its sterilizing ability.The ethanol of volume fraction 75% is close with the osmotic pressure of bacterium, constantly can infiltrate to thalline inside gradually before the non-sex change of bacterial surface protein, make the dehydration of bacterium all albumen, sex change solidifies, finally kill bacterium, concentration of alcohol lower than 75% time, because permeability reduces, also sterilizing ability can be affected.
Power and its concentration of ethanol sterilizing power have direct relation, too high or too low all not all right, and effect is it is preferred that the ethanol of volume fraction 75%.Thimerosal of the present invention adopts volume fraction 63%-77% ethanol, and this is ethanol disinfection best results concentration.Ethanol highly volatile, therefore, sterilization is after ethanol prepares, and the bottle sealing that should be placed in favorable sealing property is immediately preserved, for subsequent use, in order to avoid reduce concentration because of volatilization, affects bactericidal effect.In addition, the excitant of ethanol is comparatively large, and mucous membrane sterilization should avoid use.
The bactericidal action of glucose saccharic acid Chlorhexidine than ethanol start slow, but it is on skin, sterilization has suitable continuation, so the mixing sterilization of ethanol and glucose saccharic acid Chlorhexidine, not only can strengthen Disinfection Effect, can also lengthening disinfection time.Glucose saccharic acid Chlorhexidine concentration higher than 2.2% time, to skin produce stimulation larger.Thimerosal of the present invention adopts volume fraction 1.8%-2.2% chlorhexidine gluconate, and this is skin degerming optium concentration.Disinfection Effect is remarkable, and safety has no side effect.
The present invention also provides a kind of manufacture method of chlorhexidine gluconate alcohol thimerosal.Be the chlorhexidine gluconate of 1.8% ~ 2.2% according to volume fraction, volume fraction is the ethanol of 75%, and surplus is that three kinds of solution mix by the ratio of deionized water, adopts the speed of 1250r/min to be uniformly mixed solution 2 minutes at normal temperatures with magnetic stirring apparatus.Because ethanol is very easy to volatilization, thus during configuration temperature as much as possible, simultaneously in order to reduce manufacturing cost, so select at room temperature to be configured.In addition, due to the effumability of ethanol, mixing time can not be long, but the synergy in order to make chlorhexidine gluconate and ethanol can fully mix to play sterilization, need to stir fully mixed solution.Therefore, the present invention adopts the speed of 1250r/min to be uniformly mixed solution 2 minutes, reaches optimum balance between the volatilization consume of ethanol and the abundant mixing of solution.
The schematic diagram of the chlorhexidine gluconate alcohol disinfecting cotton swab provided according to a first embodiment of the present invention is provided.The cutaway view of the chlorhexidine gluconate alcohol disinfecting cotton swab provided according to a first embodiment of the present invention is provided.Please also refer to Fig. 1 and Fig. 2.
In the first embodiment, chlorhexidine gluconate alcohol disinfecting cotton swab comprises plastics cotton swab bar 1 and two cottons 2.Plastics cotton swab bar 1 have sidewall 11, blind end 12, openend 13 and by sidewall 11, blind end 12, openend 13 around the cavity 14 formed.Cavity 14 is equipped with chlorhexidine gluconate alcohol thimerosal 15, and chlorhexidine gluconate alcohol thimerosal is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, and volume fraction is the ethanol of 63% ~ 77%, and surplus is deionized water composition.Two cottons 2 are wrapped in blind end 12 and the openend 13 of plastics cotton swab bar 1 respectively.
Blind end 12 adopts heat sealing, and openend 13 adopts silicone oil fluid-tight.Heat sealing not only to thimerosal without any pollution and good sealing effect.Fluid-tight not only makes thimerosal completely cut off air, simultaneously also makes cotton swab when not using, and chlorhexidine gluconate alcohol thimerosal 15 can not infiltrate the cotton 2 at openend 13 place.Such chlorhexidine gluconate alcohol thimerosal 15 is sealed in plastics cotton swab bar 1, can not volatilize, can not be contaminated, and can preserve for a long time, effect is more stable.
Sidewall 11 has snap slot 111, and the distance D between snap slot 111 and blind end 12 is less than 1/5th of the length L of sidewall 11.Therefore, can accommodating chlorhexidine gluconate alcohol thimerosal 15 as much as possible in cavity 14.In the present embodiment, the distance D between snap slot 111 and blind end 12 equals 1/5th of the length of sidewall, and this makes after plastics cotton swab bar 1 fractures, and user still can have the plastics cotton swab bar 1 of sufficient length to grip to use the cotton 2 at blind end 12 place.In the present invention, the volume of chlorhexidine gluconate alcohol thimerosal 15 is 4/5ths of the volume of cavity 14.This makes after plastics cotton swab bar 1 fractures along snap slot 111, has abundant chlorhexidine gluconate alcohol thimerosal 15 and flow down to make cotton 2 fully to infiltrate in cavity 14.And the height of chlorhexidine gluconate alcohol thimerosal 15 in plastics cotton swab bar 1 does not exceed snap slot 111, so after plastics cotton swab bar 1 fractures, chlorhexidine gluconate alcohol thimerosal 15 can not arrive spilling more to be polluted.If the volume of chlorhexidine gluconate alcohol thimerosal 15 is less than 4/5ths of the volume of cavity 14, then thimerosal fully cannot infiltrate cotton 2, and this will affect use and the Disinfection Effect of cotton swab.In the present embodiment, the length L of sidewall 11 is 7 ~ 15cm.
In the present embodiment, the outside of sidewall 11 is coated with tag line 112 in snap slot 111 place.User can find snap slot 111 according to the position of tag line 112.In concrete use, for making mark clearly, the cotton at blind end 12 place 2 be blue, and the cotton at openend 13 place 2 is white.In the present embodiment, the tangent plane of snap slot 111 is V-arrangement.But the present invention is not limited in any way this.In other embodiment, the tangent plane of snap slot 111 can be U-shaped, semicircle or linear.
In the present embodiment, plastics cotton swab bar 1 is polypropylene plastics cotton swab bar, and cotton 2 is medical absorbent cotton.Polypropylene plastics nontoxic pollution-free, and can not corrode by thimerosal.Chlorhexidine gluconate alcohol thimerosal 15 leaves in the cotton swab bar 1 that polypropylene plastics makes, and effect is stablized, and service time is longer.Preferably, the cotton at blind end 12 place 2 adopts a coloured cotton to make, and can know the not same-action differentiating cotton 2, two ends to make user.In the present embodiment, the cotton at blind end 12 place 2 is blue.But the present invention is not limited in any way this.
In the present embodiment, chlorhexidine gluconate alcohol thimerosal is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, and volume fraction is the ethanol of 75%, and surplus is deionized water composition.Thimerosal in this compositional range, the timely bactericidal effect of sterilization and lasting fungistatic effect the best.
During concrete use, user by blind end 12 upward, exerts a force along snap slot 111 and to be fractureed by plastics cotton swab bar 1.Chlorhexidine gluconate alcohol thimerosal 15 in cavity 14 can break through the silicone oil of fluid-tight under the effect of self gravitation and outside atmospheric pressure, fully infiltrates and is wrapped in cotton on openend 13 2.And the cotton at blind end 12 place 2 is owing to being dry untainted, can be used for injecting rear hemostasis or again depositing, use convenient, clean and any waste can not be caused.Chlorhexidine gluconate alcohol disinfecting cotton swab of the present invention, carries chlorhexidine gluconate alcohol thimerosal 15 in its cavity 14, volume is large, the bottled thimerosal of Heavy Weight without the need to carrying for user, uses convenient.
In addition, because thimerosal is generally volatile substances, traditional cotton swab in use thimerosal can constantly volatilize, and when wound is larger, user need use many cotton swabs just can complete surgical dressing, uses inconvenience and waste resource.And chlorhexidine gluconate alcohol disinfecting cotton swab provided by the invention, the thimerosal in cavity 14 constantly infiltrates cotton 2, makes cotton 2 to be in saturation state in a long time, user-friendly.
The cutaway view of the chlorhexidine gluconate alcohol disinfecting cotton swab provided according to a second embodiment of the present invention is provided.As shown in Figure 3, in the second embodiment, chlorhexidine gluconate alcohol disinfecting cotton swab comprises plastics cotton swab bar 1 and two cottons 2 '.Plastics cotton swab bar 1 have sidewall 11, blind end 12, openend 13 and by sidewall 11, blind end 12, openend 13 around the cavity 14 formed.Plastics cotton swab bar 1 in second embodiment is identical with the plastics cotton swab bar 1 in the first embodiment, and similar elements adopts identical label.Below be only explained with regard to difference.
In the second embodiment, two cottons 2 ' have different shapes.Preferably, the cotton at openend 13 place 2 ' is helical form, and the cotton at blind end 12 place 2 ' is sharp mouth calabash shaped.Spiral helicine cotton 2 ' has male and fomale(M&F), and male and fomale(M&F) not only increases cotton the wetted area between 2 ' and thimerosal 15, too increases cotton the contact area between 2 ' and skin simultaneously, substantially increases the availability of thimerosal.Because children's ear-drum is thinner than adult, use cotton swab to carry out adding medicine to or clean time, what the head of a family needed accurately to control cotton swab gos deep into length, prevents injury children ear-drum.And lageniform cotton 2, due to comparatively large bottom cucurbit, can not enter duct, before only having, sharp mouth enters, and the head of a family uses safety more relieved.
Figure 4 shows that the schematic diagram of chlorhexidine gluconate alcohol sterilized cotton piece provided by the invention.As shown in Figure 4, chlorhexidine gluconate alcohol sterilized cotton piece comprises cotton piece body 3, and cotton piece body 3 is fully infiltrated by chlorhexidine gluconate alcohol thimerosal.Chlorhexidine gluconate alcohol thimerosal is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, and volume fraction is the ethanol of 63% ~ 77%, and surplus is deionized water composition.
In the present embodiment, chlorhexidine gluconate alcohol thimerosal is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, and volume fraction is the ethanol of 75%, and surplus is deionized water composition.Thimerosal in this compositional range, the timely bactericidal effect of sterilization and lasting fungistatic effect the best.
In sum, the present invention adopts the chlorhexidine gluconate of designated volume mark and the mixed solution of ethanol to make thimerosal, compares ethanolic solution and has quick and durable bactericidal effect.Meet pollution-free, non-stimulated, efficient, nontoxic, safety has no side effect, taste is friendly, be widely used, be convenient to each conditions such as transport.The manufacture method of chlorhexidine gluconate alcohol thimerosal provided by the invention, specific rotating speed is adopted to stir the specific time to the mixed solution of special ratios, make ethanol when consume of volatilizing is low, fully and chlorhexidine gluconate mix, thus play the synergy of sterilization.Chlorhexidine gluconate alcohol disinfecting cotton swab provided by the invention or cotton piece, adopt the chlorhexidine gluconate alcohol thimerosal of specific components to infiltrate, can realize quick and durable bactericidal effect.
In addition, the plastics cotton swab bar due to chlorhexidine gluconate alcohol disinfecting cotton swab is the hollow structure with blind end, and chlorhexidine gluconate alcohol thimerosal can leave in cavity, therefore thimerosal storage and carry convenient, health.Simultaneously, make plastics cotton swab bar broken by arranging snap slot, after plastics cotton swab bar fractures by user, chlorhexidine gluconate alcohol thimerosal can flow to the cotton head of open end gradually, can be used for the skin degerming before injecting or surgical dressing after cotton head is fully infiltrated.Therefore, the sterilization of cotton swab uses convenient, health.And the cotton head at blind end place can be used for injecting rear hemostasis or again depositing, use convenient, pollution-free and any waste can not be caused.By snap slot is located at specific position, chlorhexidine gluconate alcohol thimerosal is ensured, and q.s is with while infiltrating cotton head, the use of the cotton head of convenient and dry again.
Although the present invention discloses as above by preferred embodiment; but and be not used to limit the present invention, anyly know this those skilled in the art, without departing from the spirit and scope of the present invention; can do a little change and retouching, therefore protection scope of the present invention is when being as the criterion depending on claims scope required for protection.
Claims (7)
1. a chlorhexidine gluconate alcohol thimerosal, is characterized in that, is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, and volume fraction is the ethanol of 75%, and surplus is deionized water composition.
2. the manufacture method of a chlorhexidine gluconate alcohol thimerosal, it is characterized in that, comprise the steps: that according to volume fraction be the chlorhexidine gluconate of 1.8% ~ 2.2%, volume fraction is the ethanol of 75%, surplus is that three kinds of solution mix by the ratio of deionized water, adopts the speed of 1250r/min to be uniformly mixed solution two minutes at normal temperatures with magnetic stirring apparatus.
3. a chlorhexidine gluconate alcohol disinfecting cotton swab, is characterized in that, comprising:
Plastics cotton swab bar, there is sidewall, blind end, openend and by sidewall, blind end, openend is around the cavity formed, described blind end adopts heat sealing, described openend adopts silicone oil fluid-tight, described sidewall has snap slot, distance between described snap slot and blind end is less than 1/5th of the length of described sidewall, described cavity is equipped with chlorhexidine gluconate alcohol thimerosal, the volume of described chlorhexidine gluconate alcohol thimerosal is 4/5ths of the volume of described cavity, described chlorhexidine gluconate alcohol thimerosal is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, volume fraction is the ethanol of 75%, surplus is deionized water composition,
Two cotton heads, are wrapped in blind end and the openend of plastics cotton swab bar respectively.
4. chlorhexidine gluconate alcohol disinfecting cotton swab according to claim 3, is characterized in that, two cotton heads have different shapes, and the cotton head of open end is helical form, and the cotton head at blind end place is sharp mouth calabash shaped.
5. chlorhexidine gluconate alcohol disinfecting cotton swab according to claim 3, is characterized in that, the outside of described sidewall is coated with tag line in snap slot place.
6. chlorhexidine gluconate alcohol disinfecting cotton swab according to claim 3, is characterized in that, described plastics cotton swab bar is polypropylene plastics cotton swab bar, and described cotton head is medical absorbent cotton and the cotton head of described blind end is color cotton.
7. a chlorhexidine gluconate alcohol sterilized cotton piece, it is characterized in that, comprise cotton piece body, cotton piece body is fully infiltrated by chlorhexidine gluconate alcohol thimerosal, described chlorhexidine gluconate alcohol thimerosal is the chlorhexidine gluconate of 1.8% ~ 2.2% by volume fraction, volume fraction is the ethanol of 75%, and surplus is deionized water composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN105816343A (en) * | 2016-04-07 | 2016-08-03 | 成都蓝孚科技有限公司 | Quick-drying surgical hand disinfection solution and preparation method thereof |
| CN105748309A (en) * | 2016-05-04 | 2016-07-13 | 浙江焜之琳生物医药科技股份有限公司 | No-clean antibacterial hand-washing solution and preparation method |
| CN111358769A (en) * | 2018-12-25 | 2020-07-03 | 宝龄富锦生技股份有限公司 | Antimicrobial kits and articles |
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| US5158532A (en) * | 1991-09-03 | 1992-10-27 | Mike Peng | Articulated swab |
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| US20040220506A1 (en) * | 2003-04-30 | 2004-11-04 | Gordon Depresha Sharay | Designer terri stix the new and improved way of cleaning |
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| CN101310727A (en) * | 2007-05-23 | 2008-11-26 | 上海利康消毒高科技有限公司 | Alcohol-containing chlorhexidine iodine disinfectant and preparation method thereof |
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| CN102429604A (en) * | 2011-10-27 | 2012-05-02 | 吴克 | Hand disinfecting wet tissue convenient to carry |
| CN102451513A (en) * | 2010-10-26 | 2012-05-16 | 陈志� | Cotton rod and production method thereof |
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| US5158532A (en) * | 1991-09-03 | 1992-10-27 | Mike Peng | Articulated swab |
| CN2276333Y (en) * | 1996-03-04 | 1998-03-18 | 吕弋工 | Portable wound sterilizing device |
| US20040220506A1 (en) * | 2003-04-30 | 2004-11-04 | Gordon Depresha Sharay | Designer terri stix the new and improved way of cleaning |
| CN101310727A (en) * | 2007-05-23 | 2008-11-26 | 上海利康消毒高科技有限公司 | Alcohol-containing chlorhexidine iodine disinfectant and preparation method thereof |
| CN101156829A (en) * | 2007-10-19 | 2008-04-09 | 纳润（厦门）科技有限公司 | A skin superficies insulation protecting film and its preparation method |
| CN101537000A (en) * | 2008-03-17 | 2009-09-23 | 北京汉潮联创中药科技有限公司 | Multi-purpose disinfectant |
| CN102451513A (en) * | 2010-10-26 | 2012-05-16 | 陈志� | Cotton rod and production method thereof |
| CN102429604A (en) * | 2011-10-27 | 2012-05-02 | 吴克 | Hand disinfecting wet tissue convenient to carry |
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| CN103704241A (en) | 2014-04-09 |
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