CN105816343A - Quick-drying surgical hand disinfection solution and preparation method thereof - Google Patents
Quick-drying surgical hand disinfection solution and preparation method thereof Download PDFInfo
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- CN105816343A CN105816343A CN201610214914.7A CN201610214914A CN105816343A CN 105816343 A CN105816343 A CN 105816343A CN 201610214914 A CN201610214914 A CN 201610214914A CN 105816343 A CN105816343 A CN 105816343A
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- chlorhexidine gluconate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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Abstract
The invention discloses a quick-drying surgical hand disinfection solution and a preparation method of the quick-drying surgical hand disinfection solution. The quick-drying surgical hand disinfection solution mainly comprises bactericidal compositions and purified water, wherein the bactericidal compositions comprise the following raw materials which are taken as constituents: organosilicon quaternary ammonium salt, Chlorhexidine gluconate, ethanol and glycerol. The preparation method of the quick-drying surgical hand disinfection solution comprises the following steps: adding ethanol in a mixing tank, then adding the organosilicon quaternary ammonium salt, Chlorhexidine gluconate and glycerol and simultaneously stirring to be completely dissolved, then adding purified water to be diluted, and adding a pH (Potential of Hydrogen) regulator to adjust the pH value to 5.5 to 7.5 to obtain the quick-drying surgical hand disinfection solution. The disinfection solution disclosed by the invention solves the defects of slow bactericidal effect of Chlorhexidine gluconate and weak sterilization of ethanol, reaches quick disinfection and sterilization and a long-lasting antibacterial effect, can effectively protect human skin by adding glycerol, has small skin irritation, no harm to human health, convenient use, easily obtained raw materials, simple formula, suitability for industrial production and capability of being used for surgical hand washing disinfection, hygiene hand washing disinfection and daily hand disinfection.
Description
Technical field
The present invention relates to medical institutions' surgery preoperative hand-wrist bones field, be specifically related to a kind of rapid-curing cutback, the surgical hand disinfectant solution of sterilization.
Background technology
At present, the hand disinfection that medical personnel in hospital are done by preventing nosocomial infection is mainly the disinfectant solution sterilization of two kinds of disinfectant compound prescriptions or single disinfection method agent composition, lack long acting antibiotic function, it is impossible to guarantee the durable antibiotic of 4-6 hour major surgery phase, cause the risk of infection.Organosilicon quaternary ammonium salt is a class Novel Cationic Surfactants, there is in terms of antibacterial the effect of the strongest durable antibiotic, at weaving, leather, using as long-acting antibiotic agent in metal and coating, in daily use chemicals, Main Function is to be adjusted foam and viscosity as in shampoo.Chlorhexidine gluconate is the biguanide chlorobenzene antibacterial of a kind of mild, has broad-spectrum sterilization function.
The Chinese patent of Publication No. CN103704241B individually discloses chlorhexidine gluconate alcohol disinfectant solution, manufacture method and disinfecting cotton swab, cotton piece；The Chinese patent of Publication No. CN1491542A discloses quick drying sterilizing liquid and preparation method thereof, both common ground are all main proportioning chlorhexidine gluconate and the ethanol compositions of its disinfectant solution, ethanol does not possess lasting bactericidal activity, i.e. without bactericidal effect after volatilization, but single chlorhexidine gluconate bactericidal effect is bad, can not Continuous sterilization, existing general do not use in operation.The Chinese patent of Publication No. CN102429604A discloses a kind of portable hand-wrist bones moisture paper tissue papers, its main city of wet tissue liquid mainly also mainly contains chlorhexidine gluconate and ethanol, also added the materials such as Aloe extract, methyl hydroxybenzoate and essence simultaneously, in the absorption process of non-woven fabrics, few owing to adding sterilization dose, cannot thoroughly include being sterilized object, the early stage effect of its sterilization be still slow, and cannot thorough disinfection.Publication No. 200510045294.0 discloses the preparation method of a kind of organosilyl quaternary ammonium salt sterilizing agent, although wherein organosilicon quaternary ammonium salt mixes with ethanol, but main utilization is on the textile, owing to organosilicon quaternary ammonium salt is easy to fall off, and toxicity is big, it is enriched in human body surface for a long time and easily produces pathological changes；The Chinese patent of Publication No. CN101380316B discloses multifunctional external antibiotic preparation and preparation method, use benzalkonium bromide, benzalkonium chloride, organosilicon quaternary ammonium salt, ethanol together with water, by spray pattern effect, be mainly used in surface disinfection, in the hospitals such as surgical operation in-convenience in use.
In sum, the current disinfectant being added with chlorhexidine gluconate or ethanol, its bactericidal effect can not be lasting, and single effect or both immixtures do not reach the effect of long-acting bactericidal.Simultaneously as medical, owing to medical personnel need to carry out hand cleaning for a long time, the most current handwashing liquid is both greatly less than the effect of long-acting bactericidal, and containing irritant, injured the skin of medical personnel, be not therefore suitable for medical.And although organosilicon quaternary ammonium salt is as antibacterial, can long acting antibiotic, but be primarily used for surface disinfection, at present and have no for type disinfecting liquid aspect.And as disinfectant solution, between the various materials with disinfecting and sterilizing functions, it is respectively provided with certain Antagonism.Therefore by two or more disinfectant mixing, and not producing antagonism, have quick disinfecting, the medical type disinfecting liquid of long acting antibiotic sterilization is significant.
Summary of the invention
In order to solve above-mentioned deficiency and defect, the present invention proposes a kind of quick sterilization, the most antibacterial, disposable surgery hand sanitizing fluid that rapid-curing cutback is disposable and preparation method thereof.
To achieve these goals, the present invention is achieved through the following technical solutions:
A kind of rapid-curing cutback surgery hand sanitizing fluid, it is characterised in that: mainly include following raw material components, be by mass percentage:
Preferably, a kind of rapid-curing cutback surgery hand sanitizing fluid, mainly include following raw material components, be by mass percentage:
The preparation method of a kind of rapid-curing cutback surgery hand sanitizing fluid, comprises the following steps: adds ethanol in material-compound tank, adds organosilicon quaternary ammonium salt, chlorhexidine gluconate and glycerol also stir simultaneously so that it is after being completely dissolved, and add purified water dilution, add pH adjusting agent regulation pH to 5.5-7.5, to obtain final product.
Preferably, described pH adjusting agent is the sodium hydroxide solution of 1%.
In rapid-curing cutback surgery hand sanitizing fluid of the present invention, chlorhexidine gluconate is the compound that a kind of anti-microbial effect is the strongest, the effect of chlorhexidine gluconate starts slowly than alcohols, but it has suitable persistence on skin, therefore as operating disinfectant solution, it is stayed has lasting chemical antimicrobial acivity on skin, and causes the sensitive or light activated probability of contact the least, also by complete skin absorption, improve antibacterial effect.Organosilicon quaternary ammonium salt is a kind of Novel Cationic Surfactants, electronegative antibacterial can be adsorbed, there is good bactericidal action, its sterilization mechanism is: using organosilicon as medium, the ammonium cation group with bactericidal property is adsorbed in forcefully the surface of antibacterial, change the permeability of bacteria cell wall, make endobacillary enzyme, coenzyme and metabolic intermediate overflow, microorganism is caused to cease breathing function and lethal, thus reach sterilization, antibacterial effect, i.e. there occurs " contact death ", quick sterilization, there is no the disinfectant correlation technique using this composition as hand-wrist bones at present.Chlorhexidine gluconate and organosilicon quaternary ammonium salt are cationic surfactant, and as the main component of disinfectant solution disinfection, both carry out synergism by special ratios, have quick sterilization, the effect of long acting antibiotic.Ethanol is known disinfectant, but simple ethanol can not kill bacterial spore, can not kill hepatitis virus, can only achieve the effect of common sterilization.The addition of ethanol in the present invention, both as solvent, again as disinfectant, can also play its character quickly volatilized simultaneously, quickly take away moisture and evaporate, reached the effect that rapid-curing cutback is disposable after washing one's hands.
In rapid-curing cutback surgery hand sanitizing fluid of the present invention, compared with prior art, it has the beneficial effects that:
(1) by chlorhexidine gluconate, organosilicon quaternary ammonium salt and the ethanol compound proportioning by science, three carries out synergism, makes each raw material play its characteristic, does not produce antagonism, reach the purpose of compound synergic, and bactericidal effect is better than similar.Instant invention overcomes chlorhexidine gluconate bactericidal action slow, the ethanol unabiding shortcoming of sterilization, reach Quick disinfection sterilization, the effect of long-acting bacteriostatic；And utilize the effect that ethanol quickly volatilizees, make disinfectant solution reach rapid-curing cutback.
(2) glycerol is added in the present invention; can effectively protect human body skin; little to skin irritation; the chlorhexidine gluconate simultaneously added and organosilicon quaternary ammonium salt are to health non-hazardous, and occupation mode is versatile and flexible, and available wet tissue adhesional wetting is cleaned; also can be loaded in spray bottle; easy to use, it is not necessary to baker, the fast rapid-curing cutback of naturalness.
(3) raw bactericidal material used by the present invention is medical grade or cosmetics-stage, non-stimulated to skin, and raw material sources are convenient, formula is simple, and collocation method is easy, is suitable for industrialized production, and of many uses, can be used for surgical hand sterilization, sanitary washing sterilization and daily handwashing disinfection.
The sterilization effect of rapid-curing cutback surgery hand sanitizing fluid stock solution of the present invention is as shown in table 1:
| Effect microorganism | Time | Kill logarithm value |
| Staphylococcus aureus | 1min | ≥5.00 |
| Escherichia coli | 1min | ≥5.00 |
| Streptococcus albus | 1min | ≥4.00 |
| Pseudomonas aeruginosa (ATCC15442) | 1min | ≥5.00 |
| Natural bacteria on hand | 1min | ≥5.00 |
Table 1
The toxicologic index of rapid-curing cutback surgery hand sanitizing fluid of the present invention is as shown in table 2:
| Project | Judging index |
| Acute oral toxicity test | Nontoxic |
| Repeatedly intact skin irritant test | Non-stimulated |
| Subacute toxicity test (is used) repeatedly | For observing toxic action |
| Mutagenicity test | Negative |
Table 2
Can be drawn by table 2, rapid-curing cutback surgery hand sanitizing fluid avirulence of the present invention, non-stimulated, non-hazardous safe to the human body.
Detailed description of the invention
The present invention is further described below in conjunction with specific embodiment.
Embodiment 1
A kind of rapid-curing cutback surgery hand sanitizing fluid, mainly includes following raw material components, is by mass percentage: organosilicon quaternary ammonium salt 0.5%, chlorhexidine gluconate 2%, glycerol 1.5%, ethanol 60%, its surplus is purified water.
A kind of preparation method of rapid-curing cutback surgery hand sanitizing fluid, comprise the following steps: in material-compound tank, add ethanol, add organosilicon quaternary ammonium salt, chlorhexidine gluconate and glycerol also stir simultaneously, after making it be completely dissolved, add purified water dilution, add the sodium hydroxide solution regulation pH to 5.5-7.5 of 1%, to obtain final product.
Embodiment 2
A kind of rapid-curing cutback surgery hand sanitizing fluid, mainly includes following raw material components, is by mass percentage: organosilicon quaternary ammonium salt 0.3%, chlorhexidine gluconate 1%, glycerol 5%, ethanol 75%, its surplus is purified water.
A kind of preparation method of rapid-curing cutback surgery hand sanitizing fluid, comprise the following steps: in material-compound tank, add ethanol, add organosilicon quaternary ammonium salt, chlorhexidine gluconate and glycerol also stir simultaneously, after making it be completely dissolved, add purified water dilution, add the sodium hydroxide solution regulation pH to 5.5-7.5 of 1%, to obtain final product.
Embodiment 3
A kind of rapid-curing cutback surgery hand sanitizing fluid, mainly includes following raw material components, is by mass percentage: organosilicon quaternary ammonium salt 0.2%, chlorhexidine gluconate 1%, glycerol 3%, ethanol 65%, its surplus is purified water.
A kind of preparation method of rapid-curing cutback surgery hand sanitizing fluid, comprise the following steps: in material-compound tank, add ethanol, add organosilicon quaternary ammonium salt, chlorhexidine gluconate and glycerol also stir simultaneously, after making it be completely dissolved, add purified water dilution, add the sodium hydroxide solution regulation pH to 5.5-7.5 of 1%, to obtain final product.
Embodiment 4
A kind of rapid-curing cutback surgery hand sanitizing fluid, mainly includes following raw material components, is by mass percentage: organosilicon quaternary ammonium salt 0.4%, chlorhexidine gluconate 0.5%, glycerol 0.5%, ethanol 55%, its surplus is purified water.
A kind of preparation method of rapid-curing cutback surgery hand sanitizing fluid, comprise the following steps: in material-compound tank, add ethanol, add organosilicon quaternary ammonium salt, chlorhexidine gluconate and glycerol also stir simultaneously, after making it be completely dissolved, add purified water dilution, add the sodium hydroxide solution regulation pH to 5.5-7.5 of 1%, to obtain final product.
Embodiment 5
A kind of rapid-curing cutback surgery hand sanitizing fluid, mainly includes following raw material components, is by mass percentage: organosilicon quaternary ammonium salt 0.3%, chlorhexidine gluconate 0.8%, glycerol 2%, ethanol 70%, its surplus is purified water.
A kind of preparation method of rapid-curing cutback surgery hand sanitizing fluid, comprise the following steps: in material-compound tank, add ethanol, add organosilicon quaternary ammonium salt, chlorhexidine gluconate and glycerol also stir simultaneously, after making it be completely dissolved, add purified water dilution, add the sodium hydroxide solution regulation pH to 5.5-7.5 of 1%, to obtain final product.
The technical scheme provided the embodiment of the present invention above is described in detail, principle and the embodiment of the embodiment of the present invention are set forth by specific case used herein, and the explanation of above example is only applicable to help to understand the principle of the embodiment of the present invention；Simultaneously for one of ordinary skill in the art, according to the embodiment of the present invention, all will change in detailed description of the invention and range of application, in sum, this specification content should not be construed as limitation of the present invention.
Claims (4)
1. a rapid-curing cutback surgery hand sanitizing fluid, it is characterised in that: mainly include following raw material components, be by mass percentage:
Rapid-curing cutback surgery hand sanitizing fluid the most according to claim 1, it is characterised in that: mainly include following raw material components, be by mass percentage:
3. the preparation method of a rapid-curing cutback surgery hand sanitizing fluid according to claim 1, it is characterized in that: comprise the following steps: in material-compound tank, add ethanol, add organosilicon quaternary ammonium salt, chlorhexidine gluconate and glycerol also stir simultaneously, after making it be completely dissolved, add purified water dilution, add pH adjusting agent regulation pH to 5.5-7.5, to obtain final product.
Rapid-curing cutback surgery hand sanitizing fluid the most according to claim 3, it is characterised in that: described pH adjusting agent is the sodium hydroxide solution of 1%.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107773635A (en) * | 2016-08-31 | 2018-03-09 | 瑞普（天津）生物药业有限公司 | A kind of animal skin composite disinfectant and preparation method |
| CN108157358A (en) * | 2018-03-02 | 2018-06-15 | 沈阳汇翼宁消毒科技有限公司 | A kind of thimerosal and preparation method thereof |
| CN108295004A (en) * | 2018-02-09 | 2018-07-20 | 深圳翰脉环保科技有限公司 | Clean hand disinfectant of Chinese medicine of environment-friendly type foam-like and its preparation method and application |
| CN111434334A (en) * | 2019-01-11 | 2020-07-21 | 李可 | Female gel |
| CN111529550A (en) * | 2020-04-29 | 2020-08-14 | 江苏斯微特医药科技有限公司 | Preparation method of polysaccharide quick-drying hand disinfectant |
| CN113398048A (en) * | 2021-07-01 | 2021-09-17 | 山东新华莎罗雅生物技术有限公司 | Skin-care repairing type quick-drying hand-washing-free disinfection emulsion and preparation method thereof |
| CN114010567A (en) * | 2021-10-26 | 2022-02-08 | 江苏天佑医用科技有限公司 | Sustainable sterilization nursing type cow wiping wet tissue and production method thereof |
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| CN1491542A (en) * | 2002-10-25 | 2004-04-28 | 姜晓民 | Quick drying sterilizing liquid and its producing method |
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| CN103285028A (en) * | 2013-05-14 | 2013-09-11 | 陈美儿 | Composite antibacterial agent of chitosan and organosilicone quaternary ammonium salt and preparation method of composite antibacterial agent |
| CN103704241A (en) * | 2013-12-23 | 2014-04-09 | 杭州美克恒辉实业有限公司 | Chlorhexidine gluconate ethanol disinfection solution and production method as well as disinfection cotton swab and disinfection cotton piece |
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Patent Citations (6)
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| JPH10192185A (en) * | 1997-01-10 | 1998-07-28 | Kenji Nakamura | Wet wiper |
| CN1491542A (en) * | 2002-10-25 | 2004-04-28 | 姜晓民 | Quick drying sterilizing liquid and its producing method |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107773635A (en) * | 2016-08-31 | 2018-03-09 | 瑞普（天津）生物药业有限公司 | A kind of animal skin composite disinfectant and preparation method |
| CN108295004A (en) * | 2018-02-09 | 2018-07-20 | 深圳翰脉环保科技有限公司 | Clean hand disinfectant of Chinese medicine of environment-friendly type foam-like and its preparation method and application |
| CN108295004B (en) * | 2018-02-09 | 2021-04-02 | 深圳翰脉环保科技有限公司 | Environment-friendly foam-like traditional Chinese medicine hand-cleaning disinfectant and preparation method and application thereof |
| CN108157358A (en) * | 2018-03-02 | 2018-06-15 | 沈阳汇翼宁消毒科技有限公司 | A kind of thimerosal and preparation method thereof |
| CN111434334A (en) * | 2019-01-11 | 2020-07-21 | 李可 | Female gel |
| CN111529550A (en) * | 2020-04-29 | 2020-08-14 | 江苏斯微特医药科技有限公司 | Preparation method of polysaccharide quick-drying hand disinfectant |
| CN113398048A (en) * | 2021-07-01 | 2021-09-17 | 山东新华莎罗雅生物技术有限公司 | Skin-care repairing type quick-drying hand-washing-free disinfection emulsion and preparation method thereof |
| CN114010567A (en) * | 2021-10-26 | 2022-02-08 | 江苏天佑医用科技有限公司 | Sustainable sterilization nursing type cow wiping wet tissue and production method thereof |
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Application publication date: 20160803 |