CN103704241A - Chlorhexidine gluconate ethanol disinfection solution and production method as well as disinfection cotton swab and disinfection cotton piece - Google Patents
Chlorhexidine gluconate ethanol disinfection solution and production method as well as disinfection cotton swab and disinfection cotton piece Download PDFInfo
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- CN103704241A CN103704241A CN201310719533.0A CN201310719533A CN103704241A CN 103704241 A CN103704241 A CN 103704241A CN 201310719533 A CN201310719533 A CN 201310719533A CN 103704241 A CN103704241 A CN 103704241A
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Abstract
The invention provides a chlorhexidine gluconate ethanol disinfection solution and a production method as well as a disinfection cotton swab and a disinfection cotton piece. The chlorhexidine gluconate ethanol disinfection solution is composed of the following components in percentage by volume: 1.8%-2.2% of chlorhexidine gluconate, 63%-77% of ethanol and the balance being de-ionized water. According to the chlorhexidine gluconate ethanol disinfection solution, the disinfection solution is prepared by mixing the chlorhexidine gluconate and the ethanol according to specific volume percents; compared with an ethanol solution, the chlorhexidine gluconate ethanol disinfection solution has a rapid and lasting sterilization effect. Various conditions of no pollution, no irritation, high efficiency, no toxin, friendly taste, wide application, convenience for transportation and the like are met. The chlorhexidine gluconate ethanol disinfection cotton swab or cotton piece is soaked in the chlorhexidine gluconate ethanol disinfection solution with the specific components and can achieve the rapid and lasting sterilization effect.
Description
Technical field
The present invention relates to a kind of thimerosal and disinfector, relate in particular to a kind of chlorhexidine gluconate alcohol thimerosal, manufacture method and disinfecting cotton swab, cotton sheet.
Background technology
The skin of the regular use that current domestic medical system is a large amount of and other disinfectant in field, such as the tincture of iodine, Iodophor, povidone iodine etc., yet the most excitant of existing disinfectant is strong, dyeing obviously, toxicity is large, taste is unfriendly, contaminated environment, purposes are single.And can not eliminate up hill and dale bacterium and the most virus of growing, exist antibacterial effect not remarkable, the unconspicuous defect of lasting effect, during flushing, user easily feels obvious shouting pain.
In existing disinfectant, ethanol belongs to middle effect disinfectants, and its bactericidal action is very fast, Disinfection Effect is reliable, little to people's excitant, is usually used in the sterilization of skin degerming and clinical treatment apparatus.Ethanol is kill vegetative forms of bacteria rapidly, and the ethanol that volume fraction is 40～60% is the most effective to staphylococcus, but effect slowly.Volume fraction is that 60～75% ethanol effect 5min can kill the bacterial propagule that comprises a bacillus, and to micrococcus scarlatinae, gonococcus, typhoid bacillus and Pseudomonas aeruginosa, can in 1 minute, kill.Ethanol, when higher volume fraction (> 80%), has well (comprising picornavirus and the hepatitis B) effect of killing the virus, and inactivation of viruses generally needs 3～10min.Ethanol has and suppresses and killing action fungi, and volume fraction killing fungus action effect in 70%～90% scope is better, and killing fungus spore need to longer action time, general 30～60min.Ethanol can make protein denaturation, if but the volume fraction of ethanol is too high, made the protein coagulating of bacterium surface on the contrary at once; result forms one deck dura mater; this layer of dura mater has protective effect to bacterium, prevents that ethanol from further infiltrating, so the bactericidal effect of dense ethanol is bad on the contrary.
Yet due to the volatile characteristic of ethanol, just volatilization is complete in one minute for usually ethanol, thereby can not guarantee validity and the continuation of sterilization.
Cotton head and cotton swab bar that cotton swab is comprised of medical absorbent cotton process.A cotton water imbibition is strong, inhales after full thimerosal, can by the uniform wiping of thimerosal on skin, reach Disinfection Effect, is applicable to skin degerming or surgical dressing before injection.Existing medical cotton stick could be used after cotton head need dip thimerosal in use, and that thimerosal is generally is bottled, and easily volatilization inefficacy behind Kaifeng, is repeatedly dipped and be vulnerable to pollution, and thimerosal easily spills problem when carrying, and carries inconvenience.
In addition, existing cotton swab is used for convenience of user and is cost-saving when producing, and conventionally two of cotton swab bar is all arranged to cotton head.But when reality is used, because the cotton head at two ends cannot be separated, after the cotton head of one end is used, cotton swab is contaminated can not be preserved again again.This will make a cotton availability of the other end very low, thereby causes waste.
Summary of the invention
The present invention, in order to overcome the deficiencies in the prior art, provides a kind of sterilizing effective fast, the chlorhexidine gluconate alcohol thimerosal that lasting effect is strong, manufacture method and disinfecting cotton swab easy to use, bactericidal effect is good, cotton sheet.
In order to realize an object of the present invention, the invention provides a kind of chlorhexidine gluconate alcohol thimerosal, the chlorhexidine gluconate that is 1.8%～2.2% by volume fraction, the ethanol that volume fraction is 63%～77%, surplus is that deionized water forms.
In one embodiment of the invention, the chlorhexidine gluconate that chlorhexidine gluconate alcohol thimerosal is 1.8%～2.2% by volume fraction, the ethanol that volume fraction is 75%, surplus is that deionized water forms.
In order to realize another object of the present invention, the present invention also provides a kind of manufacture method of chlorhexidine gluconate alcohol thimerosal, the chlorhexidine gluconate that to comprise the steps: according to volume fraction be 1.8%～2.2%, volume fraction is 75% ethanol, surplus is that the ratio of deionized water is mixed three kinds of solution, adopts the speed of 1250r/min to be uniformly mixed solution 2 minutes at normal temperatures with magnetic stirring apparatus.
In order to realize another object of the present invention, the present invention also provides a kind of chlorhexidine gluconate alcohol disinfecting cotton swab, comprises plastics cotton swab bar and two cotton heads.Plastics cotton swab bar there is sidewall, blind end, openend and by sidewall, blind end, openend around the cavity forming.Blind end adopts heat sealing, and openend adopts silicone oil fluid-tight.Sidewall has snap slot, the distance between snap slot and blind end be less than described sidewall length 1/5th.Cavity is equipped with chlorhexidine gluconate alcohol thimerosal, 4/5ths of the volume that the volume of chlorhexidine gluconate alcohol thimerosal is cavity.The chlorhexidine gluconate that chlorhexidine gluconate alcohol thimerosal is 1.8%～2.2% by volume fraction, the ethanol that volume fraction is 63%～77%, surplus is that deionized water forms.Two cotton heads are wrapped in respectively blind end and the openend of plastics cotton swab bar.
In one embodiment of the invention, two cotton heads have different shapes, and the cotton head of open end is helical form, and the cotton head at blind end place is sharp mouth calabash shaped.
In one embodiment of the invention, the outside of sidewall is coated with tag line in snap slot place.
In one embodiment of the invention, plastics cotton swab bar is polypropylene plastics cotton swab bar, and cotton head is that the cotton head of medical absorbent cotton and blind end is color cotton.
In one embodiment of the invention, the chlorhexidine gluconate that chlorhexidine gluconate alcohol thimerosal is 1.8%～2.2% by volume fraction, the ethanol that volume fraction is 75%, surplus is that deionized water forms.
In order to realize another object of the present invention, the present invention also provides a kind of chlorhexidine gluconate alcohol sterilized cotton piece, comprises cotton sheet body.Cotton sheet body is fully infiltrated by chlorhexidine gluconate alcohol thimerosal.The chlorhexidine gluconate that chlorhexidine gluconate alcohol thimerosal is 1.8%～2.2% by volume fraction, the ethanol that volume fraction is 63%～77%, surplus is that deionized water forms.
In sum, the present invention adopts the chlorhexidine gluconate of designated volume mark and the mixed solution of ethanol to make thimerosal, compares ethanolic solution and has quick and durable bactericidal effect.Meet pollution-free, non-stimulated, efficient, nontoxic, taste is friendly, be widely used, be convenient to each conditions such as transportation.The manufacture method of chlorhexidine gluconate alcohol thimerosal provided by the invention, to the mixed solution of special ratios, adopt specific rotating speed to stir the specific time, make ethanol in the situation that volatilization consume is low, fully and chlorhexidine gluconate mix, thereby performance sterilization synergy.Chlorhexidine gluconate alcohol disinfecting cotton swab provided by the invention or cotton sheet, adopt the chlorhexidine gluconate alcohol thimerosal of specific components to infiltrate, and can realize quick and durable bactericidal effect.
In addition, because the plastics cotton swab bar of chlorhexidine gluconate alcohol disinfecting cotton swab is the hollow structure with blind end, chlorhexidine gluconate alcohol thimerosal can leave in cavity, so the storage of thimerosal and carry convenient, health.Simultaneously, by being set, snap slot make plastics cotton swab bar broken, after user fractures plastics cotton swab bar, chlorhexidine gluconate alcohol thimerosal can flow to the cotton head of open end gradually, and cotton head be can be used for skin degerming or the surgical dressing before injection after fully infiltrating.Therefore, convenient, health is used in the sterilization of cotton swab.And the cotton head at blind end place can be used for injecting rear hemostasis or again deposits, use convenient, pollution-free and can not cause any waste.By snap slot being located to specific position, make chlorhexidine gluconate alcohol thimerosal guarantee that q.s is when infiltrating cotton head, the use of the cotton head of convenient and dry again.
For above and other objects of the present invention, feature and advantage can be become apparent, preferred embodiment cited below particularly, is described in detail below.
Accompanying drawing explanation
The schematic diagram of the chlorhexidine gluconate alcohol disinfecting cotton swab providing according to first embodiment of the invention is provided.
The cutaway view of the chlorhexidine gluconate alcohol disinfecting cotton swab providing according to first embodiment of the invention is provided.
The cutaway view of the chlorhexidine gluconate alcohol disinfecting cotton swab providing according to second embodiment of the invention is provided.
Figure 4 shows that the schematic diagram of chlorhexidine gluconate alcohol sterilized cotton piece provided by the invention.
Embodiment
The invention provides a kind of chlorhexidine gluconate alcohol thimerosal, the chlorhexidine gluconate that is 1.8%～2.2% by volume fraction, the ethanol that volume fraction is 63%～77%, surplus is that deionized water forms.
The present invention adopts the chlorhexidine gluconate of designated volume mark and the mixed solution of ethanol to make thimerosal.The bactericidal action of ethanol is due to they deformabilities to protein, good to the effect of gram-positive bacteria, Gram-negative bacteria, some drug-fast bacterias, various fungies, and its effect is rapid, and can make the speed that on skin, bacterium regrows decline.Chlorhexidine gluconate can destroy the cell wall of bacterium, causes the irreversible leakage of composition in cell membrane, thus kill bacteria.The quick sterilization effect of chlorhexidine gluconate is slower than ethanol, but its lasting bactericidal action is better than ethanol, and it has suitable continuation (residue adheres to) on skin, also without complete skin, absorb, thereby toxicity is very little.Therefore both share, and both can expand bacterium spectrum, can obtain quick and durable bactericidal effect again.
In product, use ethanol, not only play synergistic function with chlorhexidine gluconate, and after embrocating, there is the feature of rapid-curing cutback, greatly shortened the operating time.Ethanol also plays dissolution to chlorhexidine gluconate simultaneously.By using the mixed solution of chlorhexidine gluconate and ethanol rather than all adopting ethanol, reduced the volatility of thimerosal, improved stability and the sterilizing persistence of thimerosal.
Thimerosal of the present invention detects (No. 201301078th, Zhejiang (province) disease control searching) through Zhejiang Center For Disease Control and Prevention, the chlorhexidine gluconate alcohol thimerosal detecting, lot number is that this lot number of 0102220130415(comprises five bottles of chlorhexidine gluconate alcohol thimerosals, every bottle of 100ml, five bottles of corresponding components are respectively: the volume fraction of chlorhexidine gluconate is 1.8%, the volume fraction of ethanol is 63%, and the volume fraction of deionized water is 35.2%; The volume fraction of chlorhexidine gluconate is 1.9%, and the volume fraction of ethanol is 75%, and the volume fraction of deionized water is 23.1%; The volume fraction of chlorhexidine gluconate is 2.0%, and the volume fraction of ethanol is 75%, and the volume fraction of deionized water is 23.0%; The volume fraction of chlorhexidine gluconate is 2.1%, and the volume fraction of ethanol is 75%, and the volume fraction of deionized water is 22.9%; The volume fraction of chlorhexidine gluconate is 2.2%, and the volume fraction of ethanol is 77%, and the volume fraction of deionized water is 20.8%).Detect test as follows:
The test of killing to Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa
One, equipment
1. test strain: Escherichia coli 8099, staphylococcus aureus ATCC6538, pseudomonas aeruginosa ATCC15422, Chinese microbial species preservation administration committee's common micro-organisms center provides, the 5th, 6 generation slant culture.
2. neutralizer 1: containing the TPS of 1% lecithin, 10% Tween-80.
3. neutralizer 2: containing the TPS of 0.12% lecithin, 1.2% Tween-80.
4. thimerosal: chlorhexidine gluconate alcohol thimerosal, lot number 0102220130415.
Two, method
1. test basis: neutralizer approval test, quantitative disinfecting test are by the < < of Ministry of Public Health disinfection technology standard > > (version in 2002) 2.1.1.5.5 bar, 2.1.1.7.4 bar.
2. neutralizer approval test: with 8 times of dilutions of neutralizer 1 and sample stoste, neutralizer 2 and sample respectively with Escherichia coli effect 0.5min, 20 ℃ of temperature for experimental enviroment, test repeats 3 times.
3. bactericidal assay: with containing the effect of sample stoste, 20 ℃ of temperature for experimental enviroment, test repeats 3 times.
Three, result
Killing effect to test organisms
Note: the equal asepsis growth of each negative control
Four, conclusion:
1. the neutralizer that contains the TPS of 1.0% lecithin, 10% Tween-80 is applicable to this thimerosal through evaluation Escherichia coli, staphylococcus aureus, quantitatively killing of pseudomonas aeruginosa is tested and the result for spot disinfection test.
2. through 3 repeated tests, show, under 20 ℃ of conditions, this thimerosal effect 0.5min, kills logarithm value >5.00 to the Escherichia coli in suspension, staphylococcus aureus, pseudomonas aeruginosa.
The test of killing to Candida albicans
One, equipment
1. test strain: Candida albicans ATCC10231, Chinese microbial species preservation administration committee's common micro-organisms center provides, the 5th, 6 generation slant culture.
2. neutralizer 1: containing the TPS of 1% lecithin, 10% Tween-80.
3. neutralizer 3: containing the TPS of 0.25% lecithin, 2.5% Tween-80.
4. thimerosal: chlorhexidine gluconate alcohol thimerosal, lot number 0102220130415.
Two, method
1. test basis: neutralizer approval test, quantitative disinfecting test are by the < < of Ministry of Public Health disinfection technology standard > > (version in 2002) 2.1.1.5.5 bar, 2.1.1.9 bar.
2. neutralizer approval test: with 4 times of dilutions of neutralizer 1 and sample stoste, neutralizer 3 and sample respectively with Candida albicans effect 0.5min, 20 ℃ of temperature for experimental enviroment, test repeats 3 times.
3. bactericidal assay: with the effect of sample stoste, 20 ℃ of temperature for experimental enviroment, test repeats 3 times.
Three, result
Killing effect to test organisms
Note: the equal asepsis growth of each negative control
Four, conclusion:
Containing the neutralizer of the TPS of 1.0% lecithin, 10% Tween-80 through identifying that being applicable to this thimerosal quantitatively kills test to Candida albicans.
2. through 3 repeated tests, show, under 20 ℃ of conditions, this thimerosal effect 0.5min, kills logarithm value >5.00 to the Candida albicans in suspension.
Known according to above-mentioned detection result of the test, thimerosal provided by the invention has above the ordinary bactericidal effect, only need to act on 0.5min, the time of Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, Candida albicans on average kill logarithm value >5.00.
Detection test of the same type is found, the ethanol that is 75% containing volume fraction, and the chlorhexidine gluconate that volume fraction is 1.8%～2.2%, surplus is that the chlorhexidine gluconate alcohol thimerosal bactericidal effect of deionized water composition is best.
Why ethanol can sterilize is because ethanol can absorb the moisture of bacterioprotein, and its dehydration sex change is solidified, thereby reaches the object of kill bacteria.If use high concentration ethanol is too rapid to bacterioprotein dehydration, make bacterium surface protein first sex change solidify, formed the firm coating of one deck, ethanol can not infiltrate bacterium inside on the contrary well, so that affects its sterilizing ability.The ethanol of volume fraction 75% is close with the osmotic pressure of bacterium, can before sex change, constantly to thalline is inner, not infiltrate gradually at bacterium surface albumen, the all albumen dehydrations of bacterium, sex change are solidified, finally kill bacterium, concentration of alcohol is lower than 75% time, because permeability reduces, also can affect sterilizing ability.
Power and its concentration of ethanol sterilizing ability have direct relation, too high or too low all not all right, and what effect was best is the ethanol of volume fraction 75%.Thimerosal of the present invention adopts volume fraction 63%-77% ethanol, and this is ethanol disinfection best results concentration.Ethanol highly volatile, therefore, after sterilization ethanol prepares, the bottle that should be placed in immediately favorable sealing property seals preservation, standby, in order to avoid because volatilization reduces concentration, affect bactericidal effect.In addition, the excitant of ethanol is larger, and mucous membrane sterilization should be avoided use.
It is slow that the bactericidal action of glucose saccharic acid Chlorhexidine starts than ethanol, but it on skin, sterilization has suitable continuation, so the mixing of ethanol and glucose saccharic acid Chlorhexidine sterilization not only can be strengthened Disinfection Effect, can also lengthening disinfection time.Glucose saccharic acid Chlorhexidine concentration is higher than 2.2% time, and the stimulation that skin is produced is larger.Thimerosal of the present invention adopts volume fraction 1.8%-2.2% chlorhexidine gluconate, and this is skin degerming optium concentration.Disinfection Effect is remarkable, and safety has no side effect.
The present invention also provides a kind of manufacture method of chlorhexidine gluconate alcohol thimerosal.The chlorhexidine gluconate that is 1.8%～2.2% according to volume fraction, the ethanol that volume fraction is 75%, the ratio that surplus is deionized water is mixed three kinds of solution, adopts the speed of 1250r/min to be uniformly mixed solution 2 minutes at normal temperatures with magnetic stirring apparatus.Because ethanol is very easy to volatilization, thus during configuration temperature as much as possible, simultaneously in order to reduce manufacturing cost, so select to be at room temperature configured.In addition, due to the effumability of ethanol, mixing time can not be long, but in order to make chlorhexidine gluconate and ethanol can fully mix to bring into play the synergy of sterilization, need to stir fully mixed solution.Therefore, the present invention adopts the speed of 1250r/min to be uniformly mixed solution 2 minutes, between the volatilization consume of ethanol and the abundant mixing of solution, reaches optimum balance.
The schematic diagram of the chlorhexidine gluconate alcohol disinfecting cotton swab providing according to first embodiment of the invention is provided.The cutaway view of the chlorhexidine gluconate alcohol disinfecting cotton swab providing according to first embodiment of the invention is provided.Please also refer to Fig. 1 and Fig. 2.
In the first embodiment, chlorhexidine gluconate alcohol disinfecting cotton swab comprises plastics cotton swab bar 1 and two cottons 2.Plastics cotton swab bar 1 there is sidewall 11, blind end 12, openend 13 and by sidewall 11, blind end 12, openend 13 around the cavity 14 forming.Cavity 14 is equipped with chlorhexidine gluconate alcohol thimerosal 15, the chlorhexidine gluconate that chlorhexidine gluconate alcohol thimerosal is 1.8%～2.2% by volume fraction, and the ethanol that volume fraction is 63%～77%, surplus is that deionized water forms.Two cottons 2 are wrapped in respectively blind end 12 and the openend 13 of plastics cotton swab bar 1.
In the present embodiment, the outside of sidewall 11 is coated with tag line 112 in snap slot 111 places.User can find snap slot 111 according to the position of tag line 112.In concrete use, for making sign clearer, the cotton at blind end 12 places 2 be blue, and the cotton at openend 13 places 2 is white.In the present embodiment, the tangent plane of snap slot 111 is V-arrangement.Yet the present invention is not limited in any way this.In other embodiment, the tangent plane of snap slot 111 can be U-shaped, semicircle or linear.
In the present embodiment, plastics cotton swab bar 1 is polypropylene plastics cotton swab bar, and cotton 2 is medical absorbent cotton.Polypropylene plastics nontoxic pollution-free, and not corroded by thimerosal.Chlorhexidine gluconate alcohol thimerosal 15 leaves in the cotton swab bar 1 that polypropylene plastics makes, and effect is stable, and service time is longer.Preferably, the cotton at blind end 12 places 2 adopts a coloured cotton to make, so that user can know the not same-action of differentiating cotton 2, two ends.In the present embodiment, the cotton at blind end 12 places 2 is blue.Yet the present invention is not limited in any way this.
In the present embodiment, the chlorhexidine gluconate that chlorhexidine gluconate alcohol thimerosal is 1.8%～2.2% by volume fraction, the ethanol that volume fraction is 75%, surplus is that deionized water forms.Thimerosal in this compositional range, the timely bactericidal effect of sterilization and lasting fungistatic effect are best.
During concrete use, user by blind end 12 upward, fractures plastics cotton swab bar 1 along snap slot 111 application of forces.Chlorhexidine gluconate alcohol thimerosal 15 in cavity 14 can break through the silicone oil of fluid-tight under the effect of self gravitation and outside atmospheric pressure, fully infiltrates the cotton that is wrapped on openend 13 2.And the cotton at blind end 12 places 2 is owing to being dry untainted, can be used for injecting rear hemostasis or again deposit, use convenient, clean and can not cause any waste.Chlorhexidine gluconate alcohol disinfecting cotton swab of the present invention, carries chlorhexidine gluconate alcohol thimerosal 15 in its cavity 14, volume is large, the bottled thimerosal of Heavy Weight without carrying for user, uses convenient.
In addition, because thimerosal is generally volatile substances, the in use constantly volatilization of thimerosal of traditional cotton swab, when wound is larger, user need use many cotton swabs just can complete surgical dressing, uses inconvenient and waste resource.And chlorhexidine gluconate alcohol disinfecting cotton swab provided by the invention, the thimerosal in cavity 14 constantly infiltrates cotton 2, makes cotton 2 in a long time in saturation state, and person easy to use uses.
The cutaway view of the chlorhexidine gluconate alcohol disinfecting cotton swab providing according to second embodiment of the invention is provided.As shown in Figure 3, in the second embodiment, chlorhexidine gluconate alcohol disinfecting cotton swab comprises plastics cotton swab bar 1 and two cottons 2 '.Plastics cotton swab bar 1 there is sidewall 11, blind end 12, openend 13 and by sidewall 11, blind end 12, openend 13 around the cavity 14 forming.Plastics cotton swab bar 1 in the second embodiment is identical with the plastics cotton swab bar 1 in the first embodiment, and similar elements adopts same numeral.Below only with regard to difference, be explained.
In the second embodiment, two cottons 2 ' have different shapes.Preferably, the cotton at openend 13 places 2 ' is helical form, and the cotton at blind end 12 places 2 ' is sharp mouth calabash shaped.Spiral helicine cotton 2 ' has male and fomale(M&F), male and fomale(M&F) has not only increased cotton the 2 ' wetted area with 15 of thimerosals, has also increased the contact area between cotton 2 ' and skin simultaneously, has greatly improved the availability of thimerosal.Because children's ear-drum is thinner than adult, use cotton swab to add medicine to or when clean, what the head of a family needed accurately to control cotton swab gos deep into length, anti-damage children ear-drum.And lageniform cotton 2 is larger due to cucurbit bottom, can not enter duct, only have sharp mouth above to enter, the head of a family uses that safety is relieved more.
Figure 4 shows that the schematic diagram of chlorhexidine gluconate alcohol sterilized cotton piece provided by the invention.As shown in Figure 4, chlorhexidine gluconate alcohol sterilized cotton piece comprises cotton sheet body 3, and cotton sheet body 3 is fully infiltrated by chlorhexidine gluconate alcohol thimerosal.The chlorhexidine gluconate that chlorhexidine gluconate alcohol thimerosal is 1.8%～2.2% by volume fraction, the ethanol that volume fraction is 63%～77%, surplus is that deionized water forms.
In the present embodiment, the chlorhexidine gluconate that chlorhexidine gluconate alcohol thimerosal is 1.8%～2.2% by volume fraction, the ethanol that volume fraction is 75%, surplus is that deionized water forms.Thimerosal in this compositional range, the timely bactericidal effect of sterilization and lasting fungistatic effect are best.
In sum, the present invention adopts the chlorhexidine gluconate of designated volume mark and the mixed solution of ethanol to make thimerosal, compares ethanolic solution and has quick and durable bactericidal effect.Meet pollution-free, non-stimulated, efficient, nontoxic, safety has no side effect, taste is friendly, be widely used, be convenient to each conditions such as transportation.The manufacture method of chlorhexidine gluconate alcohol thimerosal provided by the invention, to the mixed solution of special ratios, adopt specific rotating speed to stir the specific time, make ethanol in the situation that volatilization consume is low, fully and chlorhexidine gluconate mix, thereby performance sterilization synergy.Chlorhexidine gluconate alcohol disinfecting cotton swab provided by the invention or cotton sheet, adopt the chlorhexidine gluconate alcohol thimerosal of specific components to infiltrate, and can realize quick and durable bactericidal effect.
In addition, because the plastics cotton swab bar of chlorhexidine gluconate alcohol disinfecting cotton swab is the hollow structure with blind end, chlorhexidine gluconate alcohol thimerosal can leave in cavity, so the storage of thimerosal and carry convenient, health.Simultaneously, by being set, snap slot make plastics cotton swab bar broken, after user fractures plastics cotton swab bar, chlorhexidine gluconate alcohol thimerosal can flow to the cotton head of open end gradually, and cotton head be can be used for skin degerming or the surgical dressing before injection after fully infiltrating.Therefore, convenient, health is used in the sterilization of cotton swab.And the cotton head at blind end place can be used for injecting rear hemostasis or again deposits, use convenient, pollution-free and can not cause any waste.By snap slot being located to specific position, make chlorhexidine gluconate alcohol thimerosal guarantee that q.s is when infiltrating cotton head, the use of the cotton head of convenient and dry again.
Although the present invention is disclosed as above by preferred embodiment; yet not in order to limit the present invention, anyly know this skill person, without departing from the spirit and scope of the present invention; can do a little change and retouching, so protection scope of the present invention is when being as the criterion depending on claims scope required for protection.
Claims (10)
1. a chlorhexidine gluconate alcohol thimerosal, is characterized in that, the chlorhexidine gluconate that is 1.8%～2.2% by volume fraction, and the ethanol that volume fraction is 63%～77%, surplus is that deionized water forms.
2. chlorhexidine gluconate alcohol thimerosal according to claim 1, is characterized in that, the chlorhexidine gluconate that is 1.8%～2.2% by volume fraction, and the ethanol that volume fraction is 75%, surplus is that deionized water forms.
3. the manufacture method of a chlorhexidine gluconate alcohol thimerosal, it is characterized in that, the chlorhexidine gluconate that to comprise the steps: according to volume fraction be 1.8%～2.2%, volume fraction is 75% ethanol, surplus is that the ratio of deionized water is mixed three kinds of solution, adopts the speed of 1250r/min to be uniformly mixed solution two minutes at normal temperatures with magnetic stirring apparatus.
4. a chlorhexidine gluconate alcohol disinfecting cotton swab, is characterized in that, comprising:
Plastics cotton swab bar, there is sidewall, blind end, openend and by sidewall, blind end, openend is around the cavity forming, described blind end adopts heat sealing, described openend adopts silicone oil fluid-tight, described sidewall has snap slot, distance between described snap slot and blind end be less than described sidewall length 1/5th, described cavity is equipped with chlorhexidine gluconate alcohol thimerosal, 4/5ths of the volume that the volume of described chlorhexidine gluconate alcohol thimerosal is described cavity, the chlorhexidine gluconate that described chlorhexidine gluconate alcohol thimerosal is 1.8%～2.2% by volume fraction, volume fraction is 63%～77% ethanol, surplus is that deionized water forms,
Two cotton heads, are wrapped in respectively blind end and the openend of plastics cotton swab bar.
5. chlorhexidine gluconate alcohol disinfecting cotton swab according to claim 4, is characterized in that, two cotton heads have different shapes, and the cotton head of open end is helical form, and the cotton head at blind end place is sharp mouth calabash shaped.
6. chlorhexidine gluconate alcohol disinfecting cotton swab according to claim 4, is characterized in that, the outside of described sidewall is coated with tag line in snap slot place.
7. chlorhexidine gluconate alcohol disinfecting cotton swab according to claim 4, is characterized in that, described plastics cotton swab bar is polypropylene plastics cotton swab bar, and described cotton head is that the cotton head of medical absorbent cotton and described blind end is color cotton.
8. chlorhexidine gluconate alcohol disinfecting cotton swab according to claim 4, it is characterized in that, the chlorhexidine gluconate that described chlorhexidine gluconate alcohol thimerosal is 1.8%～2.2% by volume fraction, the ethanol that volume fraction is 75%, surplus is that deionized water forms.
9. a chlorhexidine gluconate alcohol sterilized cotton piece, it is characterized in that, comprise cotton sheet body, cotton sheet body is fully infiltrated by chlorhexidine gluconate alcohol thimerosal, the chlorhexidine gluconate that described chlorhexidine gluconate alcohol thimerosal is 1.8%～2.2% by volume fraction, volume fraction is 63%～77% ethanol, and surplus is that deionized water forms.
10. chlorhexidine gluconate alcohol sterilized cotton piece according to claim 9, it is characterized in that, the chlorhexidine gluconate that described chlorhexidine gluconate alcohol thimerosal is 1.8%～2.2% by volume fraction, the ethanol that volume fraction is 75%, surplus is that deionized water forms.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310719533.0A CN103704241B (en) | 2013-12-23 | 2013-12-23 | Chlorhexidine gluconate alcohol thimerosal, manufacture method and disinfecting cotton swab, cotton piece |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310719533.0A CN103704241B (en) | 2013-12-23 | 2013-12-23 | Chlorhexidine gluconate alcohol thimerosal, manufacture method and disinfecting cotton swab, cotton piece |
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| Publication Number | Publication Date |
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| CN103704241A true CN103704241A (en) | 2014-04-09 |
| CN103704241B CN103704241B (en) | 2016-01-20 |
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| CN201310719533.0A Active CN103704241B (en) | 2013-12-23 | 2013-12-23 | Chlorhexidine gluconate alcohol thimerosal, manufacture method and disinfecting cotton swab, cotton piece |
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| CN105748309A (en) * | 2016-05-04 | 2016-07-13 | 浙江焜之琳生物医药科技股份有限公司 | No-clean antibacterial hand-washing solution and preparation method |
| CN105816343A (en) * | 2016-04-07 | 2016-08-03 | 成都蓝孚科技有限公司 | Quick-drying surgical hand disinfection solution and preparation method thereof |
| CN111358769A (en) * | 2018-12-25 | 2020-07-03 | 宝龄富锦生技股份有限公司 | Antimicrobial kits and articles |
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| CN105816343A (en) * | 2016-04-07 | 2016-08-03 | 成都蓝孚科技有限公司 | Quick-drying surgical hand disinfection solution and preparation method thereof |
| CN105748309A (en) * | 2016-05-04 | 2016-07-13 | 浙江焜之琳生物医药科技股份有限公司 | No-clean antibacterial hand-washing solution and preparation method |
| CN111358769A (en) * | 2018-12-25 | 2020-07-03 | 宝龄富锦生技股份有限公司 | Antimicrobial kits and articles |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103704241B (en) | 2016-01-20 |
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