KR20110060981A - Anti-bacterial skin germicide cleaner composition - Google Patents

Abstract

PURPOSE: An antibacterial composition for skin sterilization and disinfection is provided to last antibacterial activity and antiseptic ability. CONSTITUTION: A skin disinfectant contains 5-15 weight% of ethanol, 0.1-0.5 weight% of benzalkonium chloride, 0.3-1.0 weight% of 1.2-hexane diol, 85-90 weight% of purified water, and 0.01-0.03 weight% of perfume. The perfume has acacia, lavender, lemon, rose, rosemary, peppermint, or lime flavor. The skin disinfectant is used for hand disinfection. The skin disinfectant is manufactured in the form of gel, lotion, cream, or mineral oil.

Description

Anti-bacterial skin germicide cleaner composition

The present invention relates to an antimicrobial skin disinfectant composition, and more particularly, to a disinfectant that has no irritation to the skin and maintains excellent antimicrobial and bactericidal efficacy.

Bacterial infection of the human body, especially skin, and microbial contamination of foods are mainly mediated by contact with others contaminated with microorganisms, environmental factors, contaminated food itself and raw materials, and hand washing and disinfection to prevent the spread of microbial contamination. This is more important than anything.

Recently, the use of hand sanitizers with fungicides and antifungal agents has been used to minimize direct and indirect microbial infection through hands.However, detergents using surfactants did not completely remove harmful microorganisms even after 3 minutes of hand washing. In the case of rinsing with ethanol for the purpose of disinfection simply, it was effective to remove harmful microorganisms within a short time, but it also removes only a small amount of bacteria and the bacteria between the skin pores again moved out of the skin. The problem is that the odor of the skin is made bad because of the resident's residence or microorganisms in the air multiply on the surface of the skin and rancid the sebum. In addition, there was a problem that can not be practically used due to ethanol-specific odor and skin dryness that occurs when the skin contact.

Therefore, there is a demand for the development of a skin disinfectant disinfectant which is excellent in antibacterial and bactericidal power in the long term and is harmless to the skin.

Therefore, the inventors of the present invention, while studying a disinfectant that does not irritate the skin and has excellent antibacterial and antimicrobial efficacy, unexpectedly significantly reduce the amount of ethanol, but can prepare a disinfectant that has excellent antibacterial and antiseptic properties for a long time. The present invention was completed.

It is an object of the present invention to provide a disinfectant which is free of irritation to the skin and which has excellent antimicrobial and bactericidal efficacy.

More specifically, it is intended to provide a skin disinfectant disinfectant which has excellent antibacterial and antiseptic properties for a long time by sterilizing pathogens and sterilizing additional residues while significantly reducing the amount of ethanol.

The present invention is characterized by consisting of 5 to 15% by weight, benzalkonium chloride 0.1 to 0.5% by weight, 1.2 to hexanediol 0.3 to 1.0% by weight, purified water 85 to 90% by weight and fragrance 0.01 to 0.03% by weight. The combination of the above components according to the present invention has the effect of sustaining the unexpected excellent antibacterial and bactericidal effects by synergistic effects of the components.

Hereinafter, the present invention will be described in detail.

The present invention provides a skin antiseptic disinfectant consisting of 5 to 15% by weight of ethanol, 0.1 to 0.5% by weight of benzalkonium chloride, 0.3 to 1.0% by weight of 1.2-hexanediol, 85 to 90% by weight of purified water and 0.01 to 0.03% by weight of perfume. .

The present invention sterilizes pathogens that can cause diseases using 7 to 12% by weight of 95% ethanol, and sterilizes additional residues including 0.2 to 0.4% by weight of benzalkonium chloride to continuously protect the bactericidal effect for a long time. In addition, 1.2-hexanediol 0.4 to 0.7% by weight for users with extremely sensitive skin, characterized in that the disinfectant has a surprising effect on safety and usability without accompanying irritation in use, it is a disinfectant for hand only It is a feature.

More specifically, 0.3 g of benzalkonium chloride and 0.5 g of 1.2-hexanediol were sequentially added to 10 g of 95% ethanol, and stirred slowly. 89.2 ml of purified water and 0.015 g of acacia flavor were added to prepare a hand sanitizer.

Ethanol constituting the skin disinfectant disinfectant of the present invention has a sterilization action and volatilization, the sterilization effect of ethanol is the best when 7 to 12% by weight, and less than 5% by weight or more than 15% by weight disinfection or sterilization effect There is almost no.

Benzalkonium chloride, which constitutes the skin disinfectant disinfectant of the present invention, has excellent antibacterial and preservative effects by synergistic effect with 1.2-hexanediol added as well as being used for the purpose of supplementing or strengthening sterilization by ethanol. Not only does it completely remove harmful microorganisms, there is an advantage that the effect on antimicrobial and bactericidal properties is maintained without residue after use. See FIGS. 1 and 2.

The fragrance constituting the skin antiseptic disinfectant of the present invention may be any one or more selected from acacia, lavender, lemon, rose, rosemary, peppermint and lime, and the fragrance is previously resisted to ethanol smell. Gives you the effect of blocking.

The skin disinfectant disinfectant according to the present invention can completely remove pathogens while significantly reducing the amount of ethanol, so that the bacteria between the skin pores again move out of the skin, so that the bacteria reside on the skin or the microorganisms in the air surface the skin. There is an advantage that can fundamentally solve the problem of worsening the smell of the skin by breeding the sebum to the rancidity.

The skin disinfectant disinfectant may further include a hardening accelerator, a skin moisturizer and a nutrient in addition to the essential ingredients, and the formulation is prepared according to a conventional method, and an ingredient such as an antioxidant, a perfume, an emollient, and an antimicrobial agent is added. It can be prepared in the form of gel lotion, cream, mineral oil type by addition.

In addition, the skin disinfectant disinfectant of the present invention can be manufactured and used in various ways, such as portable products, tabletop products, wall-hanging, etc. according to each use or viscosity.

The skin disinfectant disinfectant according to the present invention can completely remove pathogens while significantly reducing the amount of ethanol, so that the bacteria between the skin pores again move out of the skin so that the bacteria reside on the skin or the microorganisms in the air surface the skin. There is an advantage that can fundamentally solve the problem of worsening the smell of the skin by breeding the sebum to rancidity.

The skin disinfectant disinfectant according to the present invention not only prevents skin drying due to ethanol volatility, but also protects the skin with excellent feeling even after repeated use, and at the same time can block the rejection of ethanol smell by fragrance. There is an advantage.

Hereinafter, the present invention will be described in more detail with reference to specific examples. However, the present invention is not limited by the following examples, and it is apparent to those skilled in the art that various modifications or changes can be made within the scope of the technical idea of the present invention.

At this time, if there is no other definition in the technical and scientific terms used, it has a meaning generally understood by those of ordinary skill in the art. Repeated descriptions of the same technical constitution and operation as those of the conventional art will be omitted.

[ Manufacturing example Hand sanitizer

A hand sanitizer was prepared by mixing the component composition ratios of Preparation Examples 1 and 2 and Comparative Preparation Examples 1 to 4 of Table 1 with a beaker followed by stirring.

Test Example 1 Evaluation of Antimicrobial Activity

(1) Antibacterial activity comparison test

The hand sanitizers of Preparation Examples 1 and 2 and Comparative Preparation Examples 1 to 4 prepared in the above Preparation Examples were prepared using 7 kinds of bacteria, namely Streptococcus pyogenes 308A, Staphylococco, by Agar dilution. Staphylococcus aureus 1621, Escherichia coli 1039, Pseudomonas aeruginosa 9027, Salmonella typhimurium , Klebsiella oxytoca After inoculating E and Enterobacter cloacae 1321 E, the cells were incubated for 48 hours in the anaerobic condition at 37 ° C., and the concentrations of the microorganisms significantly reduced the initial bacterial count to the minimum growth inhibitory concentration (MIC) (ug / ml). The antimicrobial activity was measured.

(2) antimicrobial persistence evaluation

Escherichia coli ( Esherichia coli) for evaluating the antimicrobial persistence of the hand sanitizers of Preparation Examples 1 and 2 and Comparative Preparation Examples 1 to 4 prepared in the Preparation Examples coli ) 1039, Staphlyococcus aureus ) 1621 was inoculated by plate culture and incubated in a thermostat at 32 ° C. for 2 days.

After adjusting the initial concentration of each cultured to 1 × 10 ⁶ cfu (colony forming unit) / g control test solution (sterile physiological saline) and the test solution, that is, Preparation Examples 1 and 2, Comparative Preparation Examples 1 to 4 Disinfectants were inoculated respectively and treated for 1 h, 3 h, 6 h, and 12 h to determine the bactericidal power (%). The bactericidal power was measured by the method of the following Formula 1, and the results are shown in Table 3 below.

[Equation 1]

Sterilization (%) = (A-B) ÷ A × 100

(A: Number of bacteria from control solution after treatment for a certain time, B: Number of bacteria from test solution after treatment for a certain time)

As can be seen from the results of Table 2 and Table 3, the hand sanitizer according to the present invention has an excellent effect on the antibacterial and antiseptic properties by synergistic effect of the combination of the components compared to the comparative preparation for a long time As the antibacterial activity persists, it is effective to completely remove harmful microorganisms during hand sterilization.

[ Test Example  2] skin irritation test

In the hand disinfectants of Preparation Examples 1 and 2 and Comparative Preparation Examples 1 to 4 prepared in the above Preparation Example, for Preparation Example 2 and Comparative Preparation Example 3, which were recognized as having good antibacterial activity, In order to evaluate the safety and stimulation for the human body, a primary stimulation test was performed on the human body through a human patch test as follows. CTFA guidelines for 50 healthy men and women [Ref. The Cosmetic, Toility and Fragrance Association. Inc. Washington, D.C., 20036, 1991]. 15 μl of the sample and the solution were added dropwise to the Finn Chamber, which was placed on the back of the human body, which was the test site, and fixed with tape. Subsequently, after patching for 24 hours, the patch was removed and then again passed for 4 hours, and then the skin reaction of the test site was determined according to the following criteria, and the results were shown in Table 4 below.

<Judge criteria>

-; No erythema or unusual symptoms

±; Slightly redder than the surroundings

+; Significantly redder than the surroundings

+ +; Severe redness and swelling than around

[Equation 2]

Stimulus level = [number of ± (±) × 1 × + (number of +) × 2 × + (+ +) × 3 ×] / number of subjects

As can be seen from the results of Table 4, the disinfectant according to the present invention was confirmed that the skin irritation is significantly reduced than the disinfectant of the comparative manufacturing example, which was confirmed that the excellent safety and effectiveness applicable to the user sensitive to skin irritation to be.

In addition, in terms of usability, the amount of ethanol was significantly reduced to prevent skin drying due to ethanol volatility, so that the moisture retention was excellent and at the same time, there was no evaluation of ethanol odor by fragrance.

1 is a result showing the antimicrobial activity of Staphylococcus aureus 1621 and Escherichia coli 1039 of the disinfectant according to the comparative preparation of the present invention,

(A: before disinfectant treatment, B: after 48 hours of disinfectant treatment)

2 is a result showing the antimicrobial activity of Staphylococcus aureus 1621 and Escherichia coli 1039 of the disinfectant according to the preparation example of the present invention.

(A: before disinfectant treatment, B: after 48 hours of disinfectant treatment)

Claims (4)

Skin disinfectant disinfectant consisting of 5 to 15% by weight of ethanol, 0.1 to 0.5% by weight of benzalkonium chloride, 0.3 to 1.0% by weight of 1.2-hexanediol, 85 to 90% by weight of purified water and 0.01 to 0.03% by weight of fragrance. The method of claim 1, The fragrance is a disinfectant that is any one or more selected from acacia, lavender, lemon, rose, rosemary, peppermint and lime. The method of claim 1, The disinfectant is a skin disinfectant that is a hand sanitizer. The method of claim 3, The disinfectant is a skin disinfectant disinfectant is any one or more selected from gels, lotions, creams and mineral oil.

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