KR101881306B1 - Antimicrobial composition - Google Patents

Abstract

The present invention relates to a cosmetic, personal care and home / fabric care product that contains raspberry ketone and is a mixture of raspberry ketone and arginine derivatives or a mixture of raspberry ketone and 1,2-decane diol And a microorganism controlling functional composition for controlling bacteria and fungi using a microorganism-controlling synergy with a mixture of raspberry ketone, arginine derivative and three kinds of 1,2-decanediol.

Description

Microbial control functional composition {Antimicrobial composition}

The present invention relates to a cosmetic, personal care and home / fabric care product that contains raspberry ketone and is a mixture of raspberry ketone and arginine derivatives or a mixture of raspberry ketone and 1,2-decane diol A mixture thereof, or a mixture of three kinds of rasberry ketone, arginine derivative and 1,2-decanediol, and controlling antimicrobial agents using microorganism control synergy.

For all products that use water, preservatives are essential because microbes are easy to breed. Preservative is a medicine that prevents the decay of a material. It is a preservative to prevent the vegetable organic material from decaying due to the action of microorganisms, and a preservative is added to preserve it for the purpose of conservation. For products such as food, medicines and cosmetics, personal care, and home care, preservatives that prevent microbial decay are essential for long-term quality. Particularly, these products have a very long distribution period and are very likely to be in contact with microorganisms in their use and storage methods. In addition, since various carbon sources and nitrogen sources are mixed and moisture content necessary for microbial growth is high, Necessity is essential.

There are many controversies about the human body's harmfulness through various routes. However, when the preservative is not used or the buoyant force is weak, there is a great risk of degeneration of the product and transmission of pathogens. Also, as a cause of skin troubles and diseases caused by microbial metabolism, Is inevitable.

Preservatives used in cosmetics, personal care, and home care are very diverse. Representative cosmetic preservatives include parabolic benzoyl esters such as Metyl Paraben, Ethyl Paraben, Propyl Paraben, (Butyl Paraben), and quaternium-15, imidazolidinyl urea, diazolidinyl urea, phenoxyethanol, benzalkonium chloride ), Chlorohexidine gluconic acid and trichlosan, and the like. However, these chemical preservatives inhibit the growth of microorganisms, thereby giving microbial control effects to the products, but at the same time, they cause stimulation of the user's skin. Typical examples are formalin glass-type preservatives. Formalin glass-type preservatives, including diazolidinyl urea and imidazolidinyl urea, have recently been reviewed for safety in the world and their use is on the decline, Cleaning products and some wash off products. It is also a preservative that is prohibited in some countries, including Japan, or strictly controls its use. Until recently, the most commonly used preservative in cosmetics was parabens, but the problem of endocrine disruption has turned into phenoxyethanol. However, phenoxyethanol has also been a concern for residual phenol as a combination of ethylene oxide and phenol, and in some countries, the use of baby products has been restricted.

On the other hand, some personal care and home care products still use isothiazolinone products such as methyl isothiazolinone and chloromethyl isothiazolinone because they are economical and effective. However, regulations are expanding due to the cause of carcinogenesis , Benzoates used in some products have been reported to cause hypertension, asthma attack, and kidney disease, and there is a growing announcement that they induce cell malfunction by inactivating mitochondria.

Preservatives may have an impact on public health, and regulations are being strengthened by product groups in Korea. In the case of cosmetics, the type and composition limit are designated by the Korea Food and Drug Administration (KFDA) notification label and should be indicated on the product (Article 4 (3), Article 9 and Article 13 (6) of the Cosmetic Act, number). In addition, various legal regulations are being strengthened, such as the management of wipes by incorporating them into cosmetics regulations, and the use of kitchen detergents as raw materials for notifying the KFDA.

Recently, diols and natural extracts such as hexanediol, octanediol, and ethylhexyl glycerin have been introduced as safety measures, but they are not cost effective and can be used in some other expensive consumer products. This is a difficult situation. Therefore, there is a need for a new economical new preservative which is safe and small in use in cosmetics, personal care and home / fabric care products.

The present inventors have developed a composition that maximizes the merits and complements the disadvantages by mixing the components starting from the natural ingredients. As a result, it has been confirmed that the microorganism control ability is shown in a broad spectrum, and the harmful effects of the preservative , Skin irritation, and the like.

Raspberry Ketone and Arginine derivatives have been selected as food preservatives in cosmetics, personal care products and home / fabric care products. They have recently been identified as safe ingredients and have been widely used. 1,2-hexanediol, 1,2-octanediol, and 1,2-decanediol having a similar structure to each other.

In the present invention, cosmetics include cosmetics such as creams, lotions, and skins. Personal care products include shampoos, hair conditioners, body cleansers, hand formers, wet tissues and the like. Home and fabric care products include clothes cleaners, , Fabric softener, fragrance, etc., which are products of the life cleaning and clothing care product line.

The arginine derivatives used in the invention show efficacy of raspberry ketone to neutralize the efficacious portion of the product base, which has a microbial control spectrum in a wide range, depending on the ionic properties of the product used, and 1,2- , While Raspberry Ketone complements and elevates the low-solubility and low-efficacy regions of fungi. On the other hand, it was confirmed that raspberry ketone exerts a synergistic effect in the above combination although the ability to control microorganisms is low by itself.

Accordingly, the inventors have found that cosmetics, personal care, and groovy / fabric care compositions necessarily include raspberry ketone, and include a mixture of raspberry ketone and arginine derivative, a mixture of raspberry ketone and 1,2-decanediol, These antiseptics are effective by containing 0.001% by weight to 10% by weight of the formulation in the total amount of two or three kinds of mixed materials of raspberry ketone, alkyllo arginine derivative and 1,2-decanediol. .

Hereinafter, preferred embodiments of the present invention will be described. However, the embodiments of the present invention can be modified into various other forms, and the scope of the present invention is not limited to the embodiments described below.

The antiseptic composition of the present invention contains raspberry ketone of formula (1), arginine derivative of formula (2), cosmetics using 1,2-decanediol of formula (3) as a mixture of two or three kinds of raspberry ketone, Care, and home / fabric care compositions.

[Chemical Formula 1]

(2)

Wherein R ₁ is _one of H, CH ₃ and CH ₂ CH ₃ and R ₂ is an alkyl or alkenyl group having 5 to 21 carbon atoms.

 (3)

Raspberry ketone is a food additive. As a major aromatic compound of red raspberry, it is known to regulate adiponectin, a protein used by the body to regulate metabolism. It is a functional food that burns fat in the body effectively. Arginine derivatives and the R ₂ [Formula 1] may be such as stearyl from carbon number of 12-lauroyl, coconut alkyl, cocoyl, palm oil, R ₁ is R ₁ = H in Lauroyl Arginine, R ₁ = CH3, Lauroyl Arginine Ethylester, which is R ₁ = CH ₃ CH ₂ , and lauroyl, cocoyl, etc., can be selected for each alkyl group. Among them, Lauroyl Arginine Ethylester exemplified in the invention can be used as a food additive, and it can be confirmed that a substantial part of human safety has been verified. 1,2-decendiol has recently been recognized as a safe ingredient, and its safety has been verified as a similar substance to 1,2-hexanediol and 1,2-decanediol being expanded into microbial control components of cosmetics. However, when used alone, Was found to have efficacy over a broad spectrum when mixed with raspberry ketone.

The arginine derivatives used in the experiments of the present invention can be used in various kinds of materials, and the present inventors evaluated the preservative efficacy by structure. [Chemical Formula 1] R ₂ was used as an alkyl group as a router, R ₁ = H in Lauroyl Arginine, R ₁ = CH3 in _{Lauroyl arginine methyl ester, R 1 =} CH 3 CH MIC ( minimum with respect to the _two Lauroyl Arginine Ethylester Inhibitory concentration). Mixed strains of Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus were used as bacteria and mixed strains of Candida and fungus were used as fungi.

Lauroyl Arginine Ethylester was the most effective among the arginine derivatives used in the experiment. In the present invention, this substance is exemplified as a representative ingredient. However, the scope of claims of the present invention is not limited thereto and various arginine derivatives do.

Examples with raspberry ketone were also tested using Lauroyl Arginine Ethylester. In the present invention, three arginine derivatives are used in the experiment. In the examples, only Lauroyl Arginine Ethylester is exemplified. However, the scope of claims of the present invention is not limited thereto and includes various arginine derivatives.

FIGS. 3 and 4 are the results of experiments on the bacterial and fungal effects of the MIC concentration and the synergistic effect of the three components of raspberry ketone, Lauroyl Arginine Ethylester and 1,2-decanediol, respectively. Lauroyl Arginine Synergism was observed when using raspberry ketone as a single ingredient, compared with Ethyleste and 1,2-decanediol, respectively. Especially, all three ingredients showed the best effect.

The composition for controlling microorganisms according to the present invention is a variety of consumer products using a preservative that is safe for human body and has a wide range of antimicrobial activity and excellent antibacterial activity by combination of three components. It exhibits effective preservative ability.

1 is a graph showing the MIC (minimum inhibitory concentration) of arginine derivatives against bacteria.
2 is a graph showing the MIC (minimum inhibitory concentration) for fungi of arginine derivatives.
3 is a graph showing the MIC (minimum inhibitory concentration) against bacteria when the composition components of the present invention are mixed.
4 is a graph showing the MIC (minimum inhibitory concentration) against fungi when the composition components of the present invention are mixed.

Hereinafter, various cosmetic compositions, personal care compositions, and fabric / home care compositions will be described in detail to enable those skilled in the art to easily carry out the present invention with reference to preferred embodiments thereof . The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

1) Example 1 and Comparative Example 1: O / W lotion composition

Constituent content(%) Example 1 Comparative Example 1 Paraffin oil 5.0 5.0 Isopropyl palmitate 5.0 5.0 Three alcohol 2.0 2.0 beeswax 2.0 2.0 Setares-20 2.0 2.0 PEG-20 glyceryl stearate 1.5 1.5 Spices 0.3 0.3 Hexanediol 2.0 Raspberry ketone / lauroyl arginine ester (= 50/50) 0.2 -

2) Example 2 and Comparative Example 2: Cream composition

Constituent content(%) Example 2 Comparative Example 2 Paraffin oil 10.0 10.0 Ozokerite 4.0 4.0 Vaseline 4.0 4.0 vegetable oil 12.0 12.0 Wool wax alcohol 3.0 3.0 Spices 0.5 0.5 Phenoxyethanol 0.2 Raspberry ketone / lauroyl arginine ester (= 50/50) 0.2 -

3) Example 3 and Comparative Example 3: Body cream composition

Constituent content(%) Example 2 Comparative Example 2 Paraffin oil 10.0 10.0 Ozokerite 4.0 4.0 Vaseline 4.0 4.0 vegetable oil 12.0 12.0 Wool wax alcohol 3.0 3.0 Spices 0.5 0.5 Phenoxyethanol 0.2 Raspberry ketone / lauroyl arginine ester (= 50/50) 0.2 -

4) Examples 4-1 and 4-2 and Comparative Example 4: Body cleaner composition

Constituent content(%) Example 4-1 Example 4-2 Comparative Example 4 Sodium lauryl sulfate (25%) 37.0 37.0 37.0 Potassium cocoyl hydrolyzed collagen 20.0 20.0 20.0 Polyquaternium-7 0.5 0.5 0.5 Cocamidopropyl betaine 10.0 10.0 10.0 Sodium xylene sulfonate 1.0 1.0 1.0 Spices 0.5 0.5 0.5 Phenoxyethanol - - 0.3 Raspberry ketone / 1,2-decanediol (= 50/50) 0.3 - - Raspberry Ketone / Lauroyl Arginine Chilester /
1,2-decanediol (= 30/30/40) - 0.3 -

5) Example 5 and Comparative Example 5: Baby shampoo composition

Constituent content(%) Example 5 Comparative Example 5 Potassium cocoyl glycinate (30%) 18.0 18.0 Coco polyglucoside (50%) 15.0 15.0 Cocamidopropyl betaine (30%) 12.0 12.0 Polyquaternium-10 0.3 0.3 PEG-150 pentaerythritol chelate stearate < RTI ID = 0.0 >
PPG-2 hydroxyethicocamide 1.0 1.0 Octanediol 0.2 Raspberry ketone / 1,2-decanediol (= 50/50) 0.2 -

6) Examples 6-1 and 6-2 and Comparative Example 6: Hair shampoo composition

Constituent content(%) Example 6-1 Example 6-2 Comparative Example 6 Sodium laureth-2 sulfate (28%) 40.0 40.0 40.0 Cocamidopropyl betaine (30%) 20.0 20.0 20.0 Lauryl glucoside (50%) 15.0 15.0 15.0 Cocamidopropyl betaine 10.0 10.0 10.0 Polyquaternium-10 0.5 0.5 0.5 Spices 0.5 0.5 0.5 Octanediol - - 0.3 Raspberry ketone / lauroyl arginine ester (= 50/50) 0.3 - - Raspberry ketone / 1,2-decanediol (= 50/50) - 0.3 -

7) Example 7 and Comparative Example 7: Hair Conditioner Composition

Constituent content(%) Example 7 Comparative Example 7 Cetearyl alcohol 4.0 4.0 Biphenyltrimethylammonium chloride 2.0 2.0 Ethylhexyl isononanoate 1.0 1.0 Phenyl trimecicone 0.1 0.1 glycerin 3.0 3.0 Phenoxyethanol 0.2 Raspberry ketone / lauroyl arginine ester (= 50/50) 0.2 -

8) Example 8 and Comparative Example 8: Detergent composition for clothes

Constituent content(%) Example 8 Comparative Example 8 Laurel-7 15.0 15.0 Methyl ester ethoxylate 5.0 5.0 Sodium laureth-2 sulfate (70%) 3.0 3.0 Protease 0.1 0.1 Lipase 0.1 0.1 Coco fatty soap 2.5 2.5 Sodium xylenesulfonate (30%) 2.0 2.0 Benzyl isothiazolinone 0.3 Raspberry ketone / 1,2-decanediol (= 50/50) 0.3 -

9) Example 9 and Comparative Example 9: Kitchen cleaner composition

Constituent content(%) Example 9 Comparative Example 9 Sodium laureth-2 sulfate (28%) 45.0 45.0 Alpha olefin sulfate (50%) 12.0 12.0 Amine oxide (30%) 6.6 6.6 Citric acid 0.2 0.2 Spices 0.1 0.1 Benzoate - 0.3 Raspberry ketone / lauroyl arginine ester (= 50/50) 0.3 -

10) Examples 10-1 and 10-2 and Comparative Example 10: Liquid Soap Composition

Constituent content(%) Example 10-1 Example 10-2 Comparative Example 10 Sodium laureth-2 sulfate (70%) 18.0 18.0 18.0 Alkyl polyglucoside (50%) 10.0 10.0 10.0 Cocamidopropyl betaine (30%) 8.0 8.0 8.0 PEG-20 glyceryl monooleate 2.5 2.5 2.5 Cyclomethicone 0.5 0.5 0.5 Spices 0.3 0.3 0.3 Phenoxyethanol - - 0.3 Raspberry ketone / lauroyl arginine ester (= 50/50) 0.3 - - Raspberry Ketone / Lauroyl Arginine Chilester /
1,2-decanediol (= 30/30/40) - 0.3 -

11) Example 11 and Comparative Example 11: Fiber softener composition

Constituent content(%) Example 11 Comparative Example 11 Dihydroxyethyl cholate alkyl ester ammonium methyl sulfate 18.0 18.0 Silicone defoamer 0.03 0.03 Spices 0.4 0.4 Alkylbenzalkonium chloride - 0.2 Raspberry ketone / lauroyl arginine ester (= 50/50) 0.2 -

The above Examples and Comparative Examples were tested as in Test Method 1 below.

[Test method 1: Challenge test]

Examples and Comparative Examples Each of the products prepared by the composition was placed in 5 test tubes for each, and 10 ml of water was added to each of the products. The water-insoluble components were first added to the dipropylene glycol and then added.

Three mixed bacteria and two mixed fungal cultures were added to each of the five test tubes (about 10 ⁶ to 10 ⁷ cfu). The three mixed bacteria are Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, and the mixed fungi are Candida albicans and Aspergillus niger.

Bacteria were inoculated into NA (Nutrient agar) medium, and fungi were inoculated into PDA (Potato dextrose agar) medium and cultured in an incubator at 30 ° C for 24 hours. In addition, the composition samples, that is, the composition samples of the examples and the comparative examples were allowed to stand for 3 days, then inoculated into NA and PDA media in the same manner as above, and cultured in an incubator at 30 ° C for 24 hours, Were measured. Thereafter, the maintenance of the sterilizing power of the composition was confirmed in units of 1 day, 2 days, 3 days, 7 days and 14 days.

The test results are shown in Tables 12 to 15. As a result of the test, it was found that the raspberry ketone and the mixture of lauryl arginine and 7-ester used in the present invention had an equivalent advantage over the preservatives of commercialized products there was. It is a meaningful invention in that the present invention is a food additive and a very safe material as long as it is at the same level as the buoyancy of commercialized preservatives.

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Claims (6)

A microorganism controlling functional composition comprising a mixture of an alkyloyl arginine derivative represented by formula (2), a 1,2-decanediol represented by formula (3), and a raspberry ketone represented by formula (1).
[Chemical Formula 1]

(2)

(Wherein R ₁ is _one of H, CH ₃ and CH ₂ CH ₃ , and R ₂ is an alkyl or alkenyl group having 5 to 21 carbon atoms)
(3)

The method according to claim 1,
Wherein the microorganism controlling functional composition comprises 0.001% by weight to 10% by weight of a mixture of alkylloarginine derivatives, 1,2-decanediol and raspberry ketone in the whole composition.
The method according to claim 1,
Wherein the composition is a cosmetic, a personal care product, a home care, and a fabric care composition.
The method of claim 3,
The composition of the present invention can be applied to cosmetics, personal care products, home care products and fabric care products such as creams, lotions, skins, hair shampoos, hair conditioners, hair essences, body cleansers, hand cleaners, wet tissues, liquid detergents for dishwashing, Characterized in that it comprises a liquid detergent, a clothing fabric softening agent, and a fragrance.
The method according to claim 1,
Wherein the microorganism is a mixed bacterium composed of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, or a mixed fungus composed of Candida albicans and Black mold spores.
A microorganism controlling functional composition comprising a mixture of an alkyloyl arginine derivative represented by formula (2) and a raspberry ketone represented by formula (1).
[Chemical Formula 1]

(2)

(Wherein R ₁ is _one of H, CH ₃ and CH ₂ CH ₃ , and R ₂ is an alkyl or alkenyl group having 5 to 21 carbon atoms)

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