CN104873432B - Handguard type Washing free gel for disinfection and preparation method thereof - Google Patents
Handguard type Washing free gel for disinfection and preparation method thereof Download PDFInfo
- Publication number
- CN104873432B CN104873432B CN201510278396.0A CN201510278396A CN104873432B CN 104873432 B CN104873432 B CN 104873432B CN 201510278396 A CN201510278396 A CN 201510278396A CN 104873432 B CN104873432 B CN 104873432B
- Authority
- CN
- China
- Prior art keywords
- type washing
- free gel
- disinfection
- ethanol
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of handguard type Washing free gel for disinfection and preparation method thereof, including ethanol, bactericide, cosolvent, thickener, emollient, essence and pH value conditioning agent, the pungent smell by the use of essence as carrier inclusion ethanol.The hand cleanser has the advantages that sterilization, Non-water washing, handguard, not sticky, smell is comfortable.Fully it is swelled in purified water by thickener, A liquid is made;Bactericide and cosolvent are added in ethanol simultaneously, stirs, B liquid is made, B liquid is then poured into A liquid;Emollient and essence are poured into A liquid, supplement pure water adds pH value conditioning agent, regulation pH value stirs to 6.0 8.0 to after enough.
Description
Technical field
The invention belongs to antibiotic and sterilizing technical field, and in particular to handguard type Washing free gel for disinfection and preparation method thereof.
Background technology
The hand-washing article of people in the past is mainly soap, perfumed soap etc., is easily slid when they use, and meets water logging, high temperature meeting again
Soften and expend naturally, the especially easy dirt being infected with hand, bacterium, turn into pollution source.With the improvement of living standards
And the transformation of consumption idea, hand cleanser have been increasingly becoming the substitute of traditional hand-washing article, are widely used at present in hospital, guest
The various places such as shop, dining room, family.The pump head of the contact surface of hand cleanser and hand typically just bottle, can avoid cross-infection, lead to
Extruding jet nozzle is crossed, liquid can flow into the centre of the palm, and oneself can free hold dosage.Maturation and market with hand cleanser production technology
Popularization, have various special efficacies special hand cleanser constantly come out, wherein, disinfection hand cleanser is in the hand cleanser of market
The maximum one kind of occupancy volume.
Disposable hand sanitizing fluid is one kind therein, and it, which does not need water to rinse, just can play a part of washing one's hands, with general
Hand cleanser is compared, and disposable hand cleanser is not limited by water source, particularly suitable for being cleaned under water deficit conditions to hand and sterilization makes
With, it is particularly suitable for use in some in outside work or the crowd of outdoor travel, such as geological prospecting personnel, driver, miner.
The disposable hand sanitizing fluid that in the market generally uses, to Candida albicans, staphylococcus aureus, Escherichia coli etc.
The killing rate of pathogen is up to 90%.The kind of existing disposable hand sanitizing fluid is more, but there are problems that to some extent,
For example, some hand sanitizing fluids are not good enough from the aspect of the nursing to hand skin, bactericidal component is larger to the excitant of skin, long
Phase use easily causes dry hand skin, coarse, chap and decortication;(exceeded with the alcohols of high concentration in some hand sanitizing fluids
80%(v/v)) it is solvent, there is strong sharp aroma, it is difficult to be esthetically acceptable to the consumers.Chinese patent CN100434063C is disclosed
Improved water-free hand cleaning liquid, it includes carbomer 0.3-0.4%, ethanol 66-71%, aminomethyl propanol 0.3-0.4%, propane diols
2.8-3.8%, triclosan 0.4-0.5%, glycerine 2.8-3.2%, surplus are water.It need not be used during disinfecting gel use obtained by the invention
Water rinses base energy washing hand, but smell is relatively more pungent, it is difficult to be esthetically acceptable to the consumers.Chinese patent CN100394909C discloses one
Disposable hand cleanser of kind and preparation method thereof, the primary raw material and proportioning of the disposable disinfection hand cleanser are for (percentage by weight):Second
Alcohol:57%~65%;Tea oil:0.1%~2%;Card ripple:3%~5%;Bactericide triclosan:0.05% ~ 0.1%, surplus is NMF, is helped
Solvent, solubilizer etc., this formula is wrapped up the smell of ethanol using tea oil, and is also added into substantial amounts of surfactant card
Ripple so that very glutinous greasy after washing one's hands, rapid-curing cutback effect is poor, feels very bad, and production cost is higher.
To sum up, current disposable gel hand sanitizing fluid, mainly using volatile alcohols as solvent, it is contemplated that safe nothing
Toxicity requirements, ethanol, isopropanol use most.Foreign study think alcohol disinfectant have it is reliable and it is quick effect and it is good
Good tolerance, optimal ethanol disinfection bacteriocidal concentration are 75%, but when ethanol content is too high, have strong sharp aroma, it is difficult to quilt
Consumer receives.Current existing disposable hand sanitizing fluid ethanol content is generally 55-65%, but low-concentration ethanol bactericidal effect is owed
It is good, other bactericide need to be compounded.Experimental study shows that 2,4,4'- tri- chloro- 2'- dihydroxy diphenyl ethers have good bactericidal activity,
The compound is widely used in the commodity such as toothpaste, cosmetics, antimicrobial soap currently as conventional chloride bactericide, but
Allergic side effect of Denging can be caused.How reach sterilizing rate it is high while reduce hand sanitizing fluid in the pair of ethanol and bactericide
Effect, at the same make consumer use do not have glutinous greasy, smell comfortably, the effect of skin care, be a urgent problem to be solved.
The content of the invention
The technical problems to be solved by the invention are technical deficiency be present in the market existing product, there is provided one
Kind handguard type Washing free gel for disinfection, it has stronger bactericidal action, to Candida albicans, staphylococcus aureus, large intestine bar
The killing rate of the pathogens such as bacterium is up to more than 99%, and sterilization duration length, without glutinous feel after use, smell is comfortable, and can grow
Profit care both hands.
In order to solve the above technical problems, the technical solution adopted in the present invention is:Handguard type Washing free gel for disinfection, including under
State the raw material of quality proportioning:Bactericide 0.1-0.5%, cosolvent 2.1-3.5%, thickener 0.10-0.25%, emollient 0.01-
2.0%th, essence 1.8-3.0%, pH value conditioning agent 0.02-0.15%, ethanol 39-54%, surplus are water.
Preferably, handguard type Washing free gel for disinfection, the raw material of following quality proportionings is included:Bactericide 0.1-0.5%, hydrotropy
Agent 2.1-3.5%, thickener 0.1-0.15%, emollient 1.5-2.0%, essence 1.8-3.0%, pH value conditioning agent 0.1-0.15%,
Ethanol 39-45%, surplus are water.
The bactericide is normal propyl alcohol, the chloro- 2'- dihydroxy diphenyl ethers of 2,4,4'- tri-, PCMX, adjacent phenyl
One or more of mixing in phenol, OPA.
The cosolvent is Tween-20, Cremophor RH40, PEG-60 rilanit specials, cocamidopropyl propyl amide sweet tea
One or more in dish alkali, APG, empgen BB.
Preferably, the cosolvent is PEG-60 rilanit specials:Cocoamidopropyl betaine=1:4.
The thickener is one kind in carbomer, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose
It is or several.
Preferably, the solubilizer is carbomer or hydroxyethyl cellulose.
The emollient is one kind in tea oil, isopropyl myristate, glycerine, allantoin, lanolin, SIMMONDSIA CHINENSIS SEED OIL
It is or several.
The essence is the one or more in lemon, jasmine, lavender, aloe, apple, peppermint, sweet orange.
A kind of method for preparing the handguard type Washing free gel for disinfection, step are as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and cosolvent,
Mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, closed preservation is standby
With;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
Beneficial effects of the present invention are as follows:
Handguard type Washing free gel for disinfection of the present invention, including ethanol, bactericide, cosolvent, thickener, emollient, essence and
PH value conditioning agent, the bactericide are normal propyl alcohol, 2,4,4'- tri- chloro- 2'- dihydroxy diphenyl ethers, PCMX, adjacent benzene
One or more of mixing in base phenol, OPA.PCMX is a kind of liquid disinfectant phenolic, is compared
The Disinfection Effect of traditional disinfectant phenolic is more preferable, and smell is lighter, and chemical property is stable, is a kind of antimildew and antibacterial agent of wide spectrum, right
Gram-positive, negative bacterium, fungi, mould have killing effect;The chloro- 2'- dihydroxy diphenyl ethers of 2,4,4'- tri- are that a kind of wide spectrum resists
It microbial inoculum, can effectively suppress Escherichia coli, staphylococcus aureus, Candida albicans, while beneficial bacteria can be protected.Will be big
Natural decomposition is rapid, be widely used in efficient medicated soap, sanitary perfumed soap, sanitary lotion, except pin aerosol, disinfection hand cleanser, wound
Mouth sterilization spray, medical apparatus sterilizing agent, hygienic mildy wash, air freshener and deodorant for refrigerator etc., also can be in lacto
Or detect have the characteristics that efficient, safe and stable, long-acting, easy to use, environment-friendly in urine.The emollient is tea
One kind in oil, isopropyl myristate, glycerine, allantoin, lanolin, SIMMONDSIA CHINENSIS SEED OIL is set, wherein, tea oil is a kind of colourless
Or light yellow liquid, there is pleasant cardamom smell, property is gentle, and percutaneous permeability is good, does not stimulate skin, and toxicity is low,
Also there are disinfecting properties, can effectively suppress the malignant bacteria and mould of many generally existings;Isopropyl myristate is to skin
Have it is fabulous permeate, moisten and emollescence, can effectively be contacted with hair follicle in cortex, penetrate into cortex depths, and by cosmetics
In active component bring into, give full play to the effect of active ingredient;Allantoin has a promotion organization growth, cell metabolism,
The physiological functions such as cutin-softening layer, it is the good consolidant and antiulcer agents of skin trauma, can be used as alleviating and treating skin
Xerosis, skin ulcer and inflammation, skin emolliency and high resilience can be made, and have the gloss of beauty;SIMMONDSIA CHINENSIS SEED OIL has good
Permeability, be to moisten well and moisturizing oil rich in vitamin D and protein, can safeguard moisture of skin, pre- anti-wrinkle with
And softening skin.
The essence is one kind in lemon, jasmine, lavender, aloe, apple, peppermint, sweet orange, and essence used is day
Right essence, the fragrance of the natural fruity of hand sanitizing fluid or the fragrance of a flower is assigned, pleasant, feels pure and fresh.Further, add simultaneously
The chloro- 2'- dihydroxy diphenyl ethers of 2,4,4'- tri- and PCMX simultaneously exist both adding proportion control(3.8~2.2):
1, the molecule of PCMX and 2, stable chemical bond is formed between 4,4'- tri- chloro- 2'- dihydroxy diphenyl ethers, makes two
Person and the mixed smell of ethanol are significantly lower than the simple chloro- 2'- dihydroxy diphenyl ethers of addition 2,4,4'- tri- or to dimethyl between chlorine
The smell of phenol, it is important that 2,4,4'- tri- chloro- 2'- dihydroxy diphenyl ethers of aforementioned proportion are added in thimerosal and between chlorine
Xylenol, it is only necessary to less ethanol is added, on the one hand not only reduces the smell of ethanol, another aspect ethanol and 2,4,
The chloro- 2'- dihydroxy diphenyl ethers of 4'- tri- and PCMX play synergy, it is only necessary to are sprayed at sterilization and rub on hand
Can be by Escherichia coli after rubbing with the hands 5 seconds, 50 seconds, staphylococcus aureus, Candida albicans, Gram-positive, negative bacterium, fungi,
Mould can be killed completely, and the thimerosal that the bacterium for killing equivalent amount uses is 1/3rd of comparative example 1.More attach most importance to
What is wanted is the chloro- 2'- dihydroxy diphenyl ethers of 2,4,4'- tri- and the PCMX increasing for adding a small amount of ethanol and aforementioned proportion
Add the chemical property of thimerosal, beneficial bacteria can be protected.Further, 0.12 ~ 0.18% can be added in thimerosal of the invention
EM bacterium, the EM bacterium by adding aforementioned proportion can kill harmful levels of pathogens and effectively protect beneficial bacterium, and EM bacterium can reduce sterilization
The smell of liquid, the smell of thimerosal is substantially reduced almost free from extraneous odour, and add after EM bacterium due to beneficial bacterium can be protected, increase
The quantity of beneficial bacterium, the sterilizing power of thimerosal is not only increased, and when in face of the harmful bacteria of isodose, add EM bacterium
Thimerosal dosage be to be not added with the half of EM bacterium thimerosals, so as to save the dosage of thimerosal.Add in an experiment
More than the EM bacterium of aforementioned proportion, the bactericidal effect of anti-virus solution is have impact on, adds the EM bacterium less than aforementioned proportion, not but not is reduced
The smell of thimerosal, the peculiar smell of thimerosal(Do not include essence taste)Increase all the better.On the other hand although thimerosal can kill
Bacterium on hand, but hand wants contacting foodstuff, it is necessary to which thimerosal on hand is washed away when being at table, if not washing away people for a long time
It is healthy using user is endangered;The present invention is by adding the EM bacterium of proper ratio, even if not washed away on hand during user's feed
A small amount of anti-virus solution, any harm can be also caused to human body after user's feed, and contribute to human consumption.Even wash hand
Afterwards, sewage is discharged into sewer pipe and then enters river course also will not can reduce pathogen to river pollution, balance Tiny ecosystem, change
Kind environment, promotes organic pollution to decompose, and reduces BOD, COD, purifies water;The detergent power of river processing system is improved, is subtracted
Lack sludge, reduce cost;Environmental malodors are eliminated, suppress harmful pathogen propagation.Further, in the raw material of embodiment 12
The lower addition 0.006-0.012% of proportioning Cineole, Cineole have antibacterial, desinsection, clearing damp detoxication, nothing safe to the human body
Poison, and Cineole may also suppress the sharp aroma of ethanol in addition to original cooling fragrance, and then improve the sterilizing rate of product
And cooling fragrance, bactericidal effect are significantly less than embodiment 12 apparently higher than embodiment 12, ethanol smell.
Handguard type Washing free gel for disinfection preparation technology of the present invention is simple, and sterilizing rate is high;In use, water need not be used, extruding is suitable
Measure in the centre of the palm, rub the several seconds, can rapidly volatilize, can fully kill bacterium and virus, after use without glutinous soapy feeling and moistening effect it is good,
Smell is pure and fresh, cost is cheap, environmentally safe.
Embodiment
The present invention is further described in detail with reference to specific embodiment.
Comparative example 1 discloses improved water-free hand cleaning liquid using Chinese patent CN100434063C,
Embodiment 1
Handguard type Washing free gel for disinfection, include the raw material of following quality proportionings:Bactericide 0.1%, cosolvent 2.1%, thickening
Agent 0.10%, emollient 0.01%, essence 1.8%, pH value conditioning agent 0.02%, ethanol 39%, surplus are water.
The method for preparing the handguard type Washing free gel for disinfection, it can carry out as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and cosolvent,
Mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, closed preservation is standby
With;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
Embodiment 2
Handguard type Washing free gel for disinfection, include the raw material of following quality proportionings:Bactericide 0.5%, cosolvent 3.5%, thickening
Agent 0.25%, emollient 2.0%, essence 3.0%, pH value conditioning agent 0.15%, ethanol 54%, surplus are water.
The method for preparing the handguard type Washing free gel for disinfection, it can carry out as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and cosolvent,
Mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, closed preservation is standby
With;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
Embodiment 3
Handguard type Washing free gel for disinfection of the present invention, include the raw material of following quality proportionings:Ethanol 39g, OPA
0.01g, cosolvent 2.1g, carbomer 0.1g, glycerine 1.5g, peppermint 1.8g, pH value conditioning agent 0.1g, surplus is pure water.
The method for preparing the handguard type Washing free gel for disinfection, it can carry out as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and cosolvent,
Mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, closed preservation is standby
With;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
Embodiment 4
Handguard type Washing free gel for disinfection of the present invention, include the raw material of following quality proportionings:Ethanol 45g, dimethyl chlorine
Phenol 0.5g, cosolvent 3.5g, hydroxyethyl cellulose 0.15g, allantoin 2.0g, peppermint 3.0g, pH value conditioning agent 0.15g, it is remaining
Amount 100-45-0.5-3.5-0.15-2.0-3.0-0.15=45.7g is pure water.
The method for preparing the handguard type Washing free gel for disinfection, it can carry out as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and cosolvent,
Mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, closed preservation is standby
With;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
Embodiment 5
Handguard type Washing free gel for disinfection of the present invention, include the raw material of following quality proportionings:Ethanol 42g, 2,4,4'- tri- is chloro-
2'- dihydroxy diphenyl ethers 0.3g, cosolvent 2.9g, carbomer 0.13g, allantoin 1.8g, peppermint 2.3g, pH value conditioning agent 0.12g,
Surplus is pure water.
The method for preparing the handguard type Washing free gel for disinfection, it can carry out as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and cosolvent,
Mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, closed preservation is standby
With;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
Embodiment 6
Handguard type Washing free gel for disinfection of the present invention, include the raw material of following quality proportionings:Ethanol 42g, 2,4,4'- tri- is chloro-
2'- dihydroxy diphenyl ethers 0.2375g, PCMX 0.0625g, cosolvent 2.9g, carbomer 0.13g, allantoin
1.8g, peppermint 2.3g, pH value conditioning agent 0.12g, surplus is pure water.
The method for preparing the handguard type Washing free gel for disinfection, it can carry out as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and cosolvent,
Mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, closed preservation is standby
With;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
Embodiment 7
Handguard type Washing free gel for disinfection of the present invention, include the raw material of following quality proportionings:Ethanol 42g, 2,4,4'- tri- is chloro-
2'- dihydroxy diphenyl ethers 0.2063g, PCMX 0.0937g, cosolvent 2.9g, carbomer 0.13g, allantoin
1.8g, peppermint 2.3g, pH value conditioning agent 0.12g, surplus is pure water.
The method for preparing the handguard type Washing free gel for disinfection, it can carry out as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and cosolvent,
Mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, closed preservation is standby
With;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
Embodiment 8
Handguard type Washing free gel for disinfection of the present invention, include the raw material of following quality proportionings:Ethanol 42g, 2,4,4'- tri- is chloro-
2'- dihydroxy diphenyl ethers 0.225g, PCMX 0.075g, cosolvent 2.9g, carbomer 0.13g, allantoin 1.8g,
Peppermint 2.3g, pH value conditioning agent 0.12g, surplus is pure water.
The method for preparing the handguard type Washing free gel for disinfection, it can carry out as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and hydrotropy
Agent, mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid, closed preservation is made
It is standby;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
Embodiment 9
Handguard type Washing free gel for disinfection of the present invention, include the raw material of following quality proportionings:Ethanol 42g, 2,4,4'- tri- is chloro-
2'- dihydroxy diphenyl ethers 0.225g, PCMX 0.075g, cosolvent 2.9g, carbomer 0.13g, allantoin 1.8g,
Peppermint 2.3g, pH value conditioning agent 0.12g, 0.12gEM bacterium, surplus is pure water.
The method for preparing the handguard type Washing free gel for disinfection, it can carry out as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and cosolvent,
Mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, closed preservation is standby
With;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
Embodiment 10
Handguard type Washing free gel for disinfection of the present invention, include the raw material of following quality proportionings:Ethanol 42g, 2,4,4'- tri- is chloro-
2'- dihydroxy diphenyl ethers 0.225g, PCMX 0.075g, cosolvent 2.9g, carbomer 0.13g, allantoin 1.8g,
Peppermint 2.3g, pH value conditioning agent 0.12g, 0.18gEM bacterium, surplus is pure water.
The method for preparing the handguard type Washing free gel for disinfection, it can carry out as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and cosolvent,
Mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, closed preservation is standby
With;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
Embodiment 11
Handguard type Washing free gel for disinfection of the present invention, include the raw material of following quality proportionings:Ethanol 42g, 2,4,4'- tri- is chloro-
2'- dihydroxy diphenyl ethers 0.225g, PCMX 0.075g, cosolvent 2.9g, carbomer 0.13g, allantoin 1.8g,
Peppermint 2.3g, pH value conditioning agent 0.12g, 0.15gEM bacterium, surplus is pure water.
The method for preparing the handguard type Washing free gel for disinfection, it can carry out as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and cosolvent,
Mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, closed preservation is standby
With;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
The EM bacterium use the universal EM bacterium stoste day this technology strain in the gloomy fields of sistan.
Embodiment 12
Handguard type Washing free gel for disinfection of the present invention, include the raw material of following quality proportionings:Ethanol 42g, 2,4,4'- tri- is chloro-
2'- dihydroxy diphenyl ethers 0.225g, PCMX 0.075g, PEG-60 rilanit special 0.725g, coconut oleoyl amine third
Base glycine betaine 2.175g, carbomer 0.13g, allantoin 1.8g, peppermint 2.3g, pH value conditioning agent 0.12g, 0.15gEM bacterium, surplus
For pure water.
The method for preparing the handguard type Washing free gel for disinfection, it can carry out as follows:
(1)Each component is weighed in proportion, and the water of hand sanitizing fluid gross weight 30% is added in stainless steel reaction pot, will be thickened
Agent, which divides 3-5 times, to be slowly added to, stirring while adding, is carried out mechanical agitation 120 minutes with 90-120r/min speed, is dispersed to
Even cloudy dispersion, stands overnight, fully swelling, and A liquid is made;
(2)In another stainless steel reaction pot, the ethanol for accounting for hand sanitizing fluid 30% is added, adds bactericide and cosolvent,
Mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, closed preservation is standby
With;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add profit
Skin agent, essence and Yu Shui, pH value conditioning agent to PH are 6.0-8.0.
The EM bacterium use the universal EM bacterium stoste day this technology strain in the gloomy fields of sistan.
The cosolvent is PEG-60 rilanit specials:Cocoamidopropyl betaine=1:4.
Guantitative bactericidal test result, the purpose is in suspension is killed in experiment indoor measurement disinfectant or on carrier
Dosage needed for bacterial propagule and bacterial spore, to verify practical sterilization dose.The disposable hand sanitizing fluid of this formula uses 2,4,
The compound that the chloro- 2'- dihydroxy diphenyl ethers 0.225g of 4'- tri-, PCMX and ethanol various sterilization composition system are matched somebody with somebody disappears
Venom, mutual Synergistic biocidal, sterilizing ability is strong 200 times during than single use, and fungicidal spectrum is also substantially widened in addition, is overcome single
The defects of fungicidal spectrum of composition is narrow.Quantitative bacteric idal experiment result is specific as follows:Thimerosal is prepared according to this formula, is chosen golden yellow
Staphylococcus (ATCC 6538), Escherichia coli (8099), Candida albicans (ATCC 10231), pseudomonas aeruginosa
(ATCC 15442) is to poliovirus (PV-1), influenza virus (H3N2), EV71 viruses and hay bacillus conduct
Experimental strain prepares bacteria suspension and carries out quantitative bacteric idal experiment.This process according to《Disinfection technology standard》The side of (version in 2002)
Method step is carried out, and will not be repeated here.Experimental result such as following table:Bactericidal effect in table is killing rate after acting on 25 seconds.
Experimental result such as following table:Bactericidal effect in table is killing rate after acting on 50 seconds
Claims (12)
1. a kind of handguard type Washing free gel for disinfection, it is characterised in that include the raw material of following quality proportionings:Bactericide 0.1-
0.5%th, cosolvent 2.1-3.5%, thickener 0.10-0.25%, emollient 0.01-2.0%, essence 1.8-3.0%, pH value regulator
0.02-0.15%, ethanol 39-54%, surplus are water;The bactericide is 2,4,4,- three chloro- 2,- dihydroxy diphenyl ether and between chlorine two
Methylphenol according to(3.8~2.2):1 mixture.
2. handguard type Washing free gel for disinfection according to claim 1, it is characterised in that:The dosage of the ethanol is 39-
42%。
3. handguard type Washing free gel for disinfection according to claim 1, it is characterised in that also include the original of following weight proportion
Material:0.12 ~ 0.18% EM bacterium.
4. handguard type Washing free gel for disinfection according to claim 1, it is characterised in that:The cosolvent be Tween-20,
Cremophor RH40, PEG-60 rilanit specials, Cocoamidopropyl betaine, APG, empgen BB
In one or more.
5. handguard type Washing free gel for disinfection according to claim 4, it is characterised in that:Cosolvent is PEG-60 hydrogenated castors
Oil:Cocoamidopropyl betaine=1:4.
6. handguard type Washing free gel for disinfection according to claim 1, it is characterised in that:The thickener is carbomer, hydroxyl
One or more in ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose.
7. handguard type Washing free gel for disinfection according to claim 1, it is characterised in that:The emollient is tea oil, meat
One or more in isopropyl myristate, glycerine, allantoin, lanolin, SIMMONDSIA CHINENSIS SEED OIL.
8. handguard type Washing free gel for disinfection according to claim 1, it is characterised in that:The essence is lemon extract, jasmine
One or more in jasmine essence, lavender oil, aloe flavour, flavoring apple essence, Mint Essence, orange flavor.
9. handguard type Washing free gel for disinfection according to claim 1, it is characterised in that:The pH value regulator is three ethanol
Amine.
10. handguard type Washing free gel for disinfection according to claim 5, it is characterised in that include the original of following weight proportion
Material:Ethanol 42%, 2,4,4,- three chloro- 2,- dihydroxy diphenyl ether 0.225%, PCMX 0.075%, PEG-60 hydrogenation castors
Sesame oil 0.725%, Cocoamidopropyl betaine 2.175%, carbomer 0.13%, allantoin 1.8%, peppermint 2.3%, pH adjusting agent
0.12%th, EM bacterium 0.15%, surplus are water.
11. handguard type Washing free gel for disinfection according to claim 10, it is characterised in that also including following weight proportion
Raw material:0.006 ~ 0.012% Cineole.
12. the preparation method of handguard type Washing free gel for disinfection according to claim 1, comprises the following steps:
(1)Each component is weighed in proportion, and the water of handguard type Washing free gel for disinfection gross weight 30% is added in stainless steel reaction pot,
Thickener is divided 3-5 times and is slowly added to, it is stirring while adding, mechanical agitation is carried out 120 minutes with 90-120r/min speed, point
Uniform cloudy dispersion is dissipated to, is stood overnight, fully swelling, A liquid is made;
(2)In another stainless steel reaction pot, add and account for the ethanol of handguard type Washing free gel for disinfection 30%, add bactericide and
Cosolvent, mixed dissolution, mechanical agitation is carried out 8 minutes with 60-80r/min speed, until solution is clarified, B liquid is made, it is closed
Save backup;
(3)B liquid is poured into A liquid, surplus ethanol is added, hastens to stir with 60-80r/min, sequentially add emollient,
Essence and Yu Shui, pH value regulator to pH are 6.0-8.0.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510278396.0A CN104873432B (en) | 2015-05-28 | 2015-05-28 | Handguard type Washing free gel for disinfection and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510278396.0A CN104873432B (en) | 2015-05-28 | 2015-05-28 | Handguard type Washing free gel for disinfection and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104873432A CN104873432A (en) | 2015-09-02 |
CN104873432B true CN104873432B (en) | 2017-11-24 |
Family
ID=53941293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510278396.0A Active CN104873432B (en) | 2015-05-28 | 2015-05-28 | Handguard type Washing free gel for disinfection and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104873432B (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105232355A (en) * | 2015-10-19 | 2016-01-13 | 湖北穆兰同大科技有限公司 | No-clean hand lotion and preparation method thereof |
CN105362212A (en) * | 2015-12-18 | 2016-03-02 | 南京巨鲨显示科技有限公司 | Washing-free sterilizing gel and preparing method thereof |
CN105999312A (en) * | 2016-06-16 | 2016-10-12 | 山东瑞泰奇洗涤消毒科技有限公司 | Medical disinfection ultrasonic coupling agent and preparation method thereof |
CN106265449A (en) * | 2016-09-19 | 2017-01-04 | 江苏田亮日用品有限公司 | A kind of composite bactericidal handwashing liquid and preparation method thereof |
CN108434011A (en) * | 2017-02-16 | 2018-08-24 | 天津国际生物医药联合研究院 | A kind of hand cleanser and its preparation method and application |
CN106860033A (en) * | 2017-02-17 | 2017-06-20 | 南京凯创协同纳米技术有限公司 | Washing-free antibacterial is washed one's hands gel and preparation method thereof |
CN107028848A (en) * | 2017-04-01 | 2017-08-11 | 江西凝盛生物科技有限公司 | A kind of disinfection solution of disposable hand natural green |
CN107412585B (en) * | 2017-04-28 | 2020-06-23 | 吉林大学 | Green environment-friendly hand-washing-free disinfection gel and preparation method thereof |
CN107158414A (en) * | 2017-06-22 | 2017-09-15 | 江苏依柯化工有限公司 | A kind of antibacterial skin-moisturizing medical ultrasonic coupling agent of disinfection and preparation method thereof |
CN108853005A (en) * | 2018-08-12 | 2018-11-23 | 浙江丽申药业股份有限公司 | Female genital tract containing superoxide dismutase repairs gel and preparation method thereof |
CN108703921A (en) * | 2018-09-08 | 2018-10-26 | 山东卓健医疗科技有限公司 | Children's virus rapid-curing cutback hand sanitizing fluid |
CN109498732A (en) * | 2018-11-26 | 2019-03-22 | 郑州吉尔康消毒制品有限公司 | Hand-wrist bones gel and preparation method thereof |
CN109528561A (en) * | 2018-12-06 | 2019-03-29 | 浙江大学自贡创新中心 | A kind of disposable hand cleanser of mineral salt |
CN109864965A (en) * | 2019-03-28 | 2019-06-11 | 叶绿芝生物科技(中山)有限公司 | A kind of gold skin base solution composition |
CN110638726A (en) * | 2019-11-11 | 2020-01-03 | 烟台新时代健康产业日化有限公司 | Lasting antibacterial no-wash hand washing gel and preparation method thereof |
CN111346020A (en) * | 2020-04-10 | 2020-06-30 | 广州云丽生物科技有限公司 | Monoguanidine washing-free disinfection gel and preparation method thereof |
CN111358714A (en) * | 2020-04-17 | 2020-07-03 | 广州荣创优品科技有限公司 | Silouch-containing skin-care type no-clean disinfectant and preparation method thereof |
CN111514098A (en) * | 2020-05-21 | 2020-08-11 | 浙江红石梁健康科技有限公司 | Washing-free disinfection gel and preparation method thereof |
CN113749973A (en) * | 2020-06-02 | 2021-12-07 | 铑家(北京)文化发展有限公司 | Wash-free hand sanitizer and preparation method thereof |
CN111529478A (en) * | 2020-06-16 | 2020-08-14 | 广东添乐化妆品有限公司 | Moisturizing hand-washing-free disinfectant and preparation method thereof |
CN112515986A (en) * | 2020-11-16 | 2021-03-19 | 四川宸煜林业开发有限责任公司 | Shampoo containing camphor oil component and preparation method thereof |
CN112315894A (en) * | 2020-11-19 | 2021-02-05 | 聂绪明 | EM (effective microorganisms) hand sanitizer and preparation method thereof |
CN112353751A (en) * | 2020-11-19 | 2021-02-12 | 聂绪明 | EM (effective microorganisms) facial cleanser and preparation method thereof |
CN113144058A (en) * | 2021-03-03 | 2021-07-23 | 惠州市至上新材料有限公司 | Skin-moistening refreshing wash-free disinfection gel and preparation method thereof |
CN113521042A (en) * | 2021-06-28 | 2021-10-22 | 青岛童医生海洋生物科技股份有限公司 | Alcohol-free wash-free virus inactivation disinfectant special for children and preparation method thereof |
CN114010533B (en) * | 2021-11-05 | 2022-08-05 | 南开大学 | Natural sanzang gel with alcohol solubility and moisture retention, no-clean disinfection gel and application |
CN114028301B (en) * | 2021-12-28 | 2023-08-22 | 山东中大药业有限公司 | No-wash antibacterial hand sanitizer and preparation method thereof |
CN114617124B (en) * | 2022-03-29 | 2022-09-27 | 浙江美生日化用品有限公司 | Disinfecting gel bead and preparation process thereof |
CN115645455B (en) * | 2022-11-01 | 2023-08-25 | 中山自然说生物科技有限公司 | High-concentration ethanol/chitosan derivative washing-free disinfection gel composition and application thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69715444T2 (en) * | 1996-07-10 | 2003-04-30 | Steris Inc. (N.D.Ges.D. Staates Delaware), Temecula | TRICLOSAN CONTAINING SKIN CLEANSING AGENTS WITH IMPROVED EFFECTIVENESS |
CN100394909C (en) * | 2003-09-16 | 2008-06-18 | 上海拜耳科生物科技有限公司 | Antiseptic hand cleaning liquid with out water cleaning and its preparation method |
CN100434063C (en) * | 2006-06-30 | 2008-11-19 | 伊尚(上海)化妆品有限公司 | Improved water-free hand cleaning liquid |
CN101658469B (en) * | 2009-09-10 | 2011-09-21 | 上海泛亚生命科技有限公司 | Cleaning-free hand sanitizer and preparation thereof |
-
2015
- 2015-05-28 CN CN201510278396.0A patent/CN104873432B/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN104873432A (en) | 2015-09-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104873432B (en) | Handguard type Washing free gel for disinfection and preparation method thereof | |
CN104840378A (en) | Skin-care sterilization hand sanitizer and preparation method thereof | |
CN101810541B (en) | Disinfecting body wash | |
CN111449093A (en) | Natural essential oil composition with antibacterial and disinfecting effects and application thereof | |
CN106793784A (en) | Vegetalitas antimicrobial compositions | |
US8741271B2 (en) | Antimicrobial compositions containing essential oils | |
CN101766543A (en) | Hand sanitizer containing chlorine dioxide | |
CN104490630A (en) | No-washing foam hand disinfection solution and preparation method thereof | |
KR101881306B1 (en) | Antimicrobial composition | |
US20140030203A1 (en) | Antimicrobial compositions containing essential oils | |
CN103493847B (en) | Environment-friendly immersing and spraying liquid and preparation method thereof | |
CN101537004A (en) | Pubes-cleaning disinfection nursing liquid used for pudendum and vagina of human body | |
CN104382807A (en) | Alcohol-free washing-free antibacterial hand sanitizer and preparation method thereof | |
CN104547275A (en) | Hand essential oil skin-care disinfection gel and preparation method thereof | |
CN1895672B (en) | Multifunctional broad-spectrum obtundent of polyphyletic synergistic and its use | |
CN113423469A (en) | Topical disinfectant compositions | |
Sukamdi et al. | Formula Optimization of Antimicrobial Hand Sanitizer With Lemongrass Essential Oil | |
JP2010195706A (en) | New germicidal, fungicidal and moisturizing composition | |
CN104840410B (en) | A kind of disposable hand disinfection liquid and its preparation and application | |
CN110946159A (en) | Plant essence biological compound clothing mildew sweat odor removing agent | |
CN109498535A (en) | Bacteria inhibiting composition, antibacterial disposable gel and its preparation method and application | |
CN112716820A (en) | Antibacterial skin-care lotion and preparation method thereof | |
KR100321411B1 (en) | Disinfectant sanitary tissue | |
JP4587673B2 (en) | Cleaning composition | |
CN104510643A (en) | Water lily root herbal extract moisture-retention hand sanitizer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
EXSB | Decision made by sipo to initiate substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information |
Address after: 473000 Nanyang City, new energy economic and Technological Development Zone, Henan, the middle of the road in the middle of the ten Applicant after: Henan Huibo Medical Co., Ltd. Address before: Three 473000 Nanyang Road, Henan Province Li River eco industrial park Wei Applicant before: Nanyang Hui Bo Bioisystech Co., Ltd |
|
CB02 | Change of applicant information | ||
GR01 | Patent grant | ||
GR01 | Patent grant |