CN108157358A - A kind of thimerosal and preparation method thereof - Google Patents
A kind of thimerosal and preparation method thereof Download PDFInfo
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- CN108157358A CN108157358A CN201711453382.3A CN201711453382A CN108157358A CN 108157358 A CN108157358 A CN 108157358A CN 201711453382 A CN201711453382 A CN 201711453382A CN 108157358 A CN108157358 A CN 108157358A
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- chlorhexidine gluconate
- thimerosal
- glycerine
- ethyl alcohol
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/42—Aloeaceae [Aloe family] or Liliaceae [Lily family], e.g. aloe, veratrum, onion, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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Abstract
The invention discloses a kind of thimerosals, it is made of chlorhexidine gluconate, nonionic surfactant, ethyl alcohol, glycerine, aloe barbadensis Miller liquid and water, wherein, the mass concentration of chlorhexidine gluconate is 0.25%~0.35%, the mass concentration of nonionic surfactant is 0.9%~1.1%, the mass concentration of ethyl alcohol is 9%~11%, and the mass concentration of glycerine is 0.25%~0.35%, and the mass concentration of aloe barbadensis Miller liquid is 0.45%~0.55%.The thimerosal of the present invention, it is nonirritant to skin, surface of a wound disinfection available for the disinfection of environment, space, object table, fabric, fruits and vegetables, hand, skin, the surface of a wound etc.；Space environment disinfection has no irritating odor；The disinfection of object table, textile disinfecting are non-corrosive；Hand-wrist bones Non-water washing, rapid-curing cutback, penetration are strong.Product stability is good, also has cleaning action to body surface, fabric, fruits and vegetables, hand, skin.
Description
Technical field
The present invention relates to a kind of thimerosals and preparation method thereof.
Background technology
Thimerosal is one of daily necessities, it is ensured that environmental sanitation, personal hygiene, surface cleaning health, application
Range is wide, and usage amount is big, such as：In the north in China, autumn and winter haze sky is more, to cleaning-sterilizing environment space, object table and
Disinfecting cleaning fabric（Mask, clothing）Sanitizer have wilderness demand；Family, medical institutions are to non-stimulated hand, skin, the surface of a wound
Disinfectant has wilderness demand；With the development of tourist industry, people travel outdoors, and need to carry environment, object table, hand, skin
Sterile products.But thimerosal of the prior art or irritant（For space, irritant smell for skin, has
Irritation）Or Disinfection Effect is undesirable（Fungicidal spectrum is narrow, and bactericidal effect is undesirable）, therefore, it is necessary to provide a kind of effect more
Good thimerosal.
Invention content
For the above-mentioned prior art, the present invention provides a kind of thimerosal, and preparation method thereof.
The present invention is achieved by the following technical solutions：
A kind of thimerosal, by chlorhexidine gluconate, nonionic surfactant, ethyl alcohol, glycerine, aloe barbadensis Miller liquid and water
Composition, wherein, the mass concentration of chlorhexidine gluconate is 0.25%~0.35%, and the mass concentration of nonionic surfactant is
0.9%~1.1%, the mass concentration of ethyl alcohol is 9%~11%, and the mass concentration of glycerine is 0.25%~0.35%, aloe barbadensis Miller
The mass concentration of liquid is 0.45%~0.55%.
Further, the nonionic surfactant is selected from PVP K30.
Further, the aloe barbadensis Miller liquid is the extracting solution of aloe barbadensis Miller, for existing routine in the prior art
Product, the present invention is used purchased from Shantou City, Guangdong Province, and trade name is aloe vera gel, article number DB/T2874.
Preferably, the thimerosal is by chlorhexidine gluconate, nonionic surfactant, ethyl alcohol, glycerine, Ku La
Rope aloe liquid and water composition, wherein, the mass concentration of chlorhexidine gluconate is 0.30%, the quality of nonionic surfactant
A concentration of 1.0%, the mass concentration of ethyl alcohol is 10%, and the mass concentration of glycerine is 0.230%, and the quality of aloe barbadensis Miller liquid is dense
Spend is 0.50%.
The preparation method of the thimerosal is：Chlorhexidine gluconate or commercially available chlorhexidine gluconate solution are taken, is added
Heat cools down 3 hours to 70 DEG C or more, adds in ethyl alcohol, nonionic surfactant, glycerine, Curacao reed are added after dissolving
Luxuriant growth liquid and water, stir evenly to get.Further, after stirring evenly, pH value is adjusted to 8~9（It is adjusted with sodium hydroxide）（It can
Further strengthen bactericidal effect）To get.
The present invention thimerosal, available for the disinfection of environment, space, object table, fabric, fruits and vegetables, hand, skin, the surface of a wound etc., be
A kind of novel, environmentally friendly wide spectrum water white transparency disinfectant, it is nonirritant to skin, surface of a wound disinfection；Space environment disinfection is non-stimulated
Property smell, during disinfection and disinfection descendant need not leave scene；The disinfection of object table, textile disinfecting are non-corrosive；Hand-wrist bones Non-water washing, speed
It is dry, penetration is strong.Product stability is good, also has cleaning action to body surface, fabric, fruits and vegetables, hand, skin.Without any fire
Hidden danger, the term of validity 2 years.
The thimerosal of the present invention, the content of chlorhexidine gluconate is low, can not only kill various pathogenic bacteria, but also without any secondary work
With without any irritation.Meanwhile with anti-inflammatory, moisturizing and other effects.
The chlorhexidine gluconate liquid of low concentration（Guanidine-chlorhexidine gluconate of high concentration is to the surface of a wound, mucous membrane spinosity
Swash property, environment disinfected also has certain penetrating odor）Nonirritant, non-corrosive, no anaphylaxis is without any side effects,
Stability is good, is not influenced by temperature and humidity；But the shortcomings that it is maximum is that fungicidal spectrum is narrow, it is impossible to kill the antimicrbial powers such as bacterial spore
Stronger pathogenic microorganisms is typically to be compounded to increase its bactericidal effect therewith with ethyl alcohol in the prior art, but ethyl alcohol is to skin, wound
Face is irritant, there is certain corrosivity to body surface, and environment space sterilizes irritant smell, particularly has the fire hidden
Suffer from.The present invention improves the bactericidal effect of chlorhexidine gluconate using two methods：One is heated to 70 DEG C or more, by 3
Hour cooling, is greatly improved its bactericidal effect, can kill various microorganisms；The second is using addition non-ionic surface active
Agent, aloe barbadensis Miller liquid and glycerine are to reduce the usage amount of ethyl alcohol, and the aloe barbadensis Miller liquid and non-ionic surface added
Activating agent not only inhibits bacteria, and improves sterilizing rate, also there is preferably moist anti-inflammatory effects, nonionic to skin, hand
Surfactant also has preferable cleaning effect to object table, fabric, hand and skin etc..
3rd, this product is the compounding new product of special process, can be with outstanding advantage complementation, while rejects and the defects of use, north
Square autumn and winter haze sky, to cleaning-sterilizing environment space, object table and disinfecting cleaning fabric（Mask, clothing）Sanitizer have largely
Demand；There are wilderness demand in family, medical institutions to non-stimulated hand, skin, surface of a wound disinfectant；The development of tourist industry, outside people
Go out travelling, need a large amount of portable environment, object table, hand, skin degerming product, so the listing of this product, has fine
Popularizing application prospect.
Description of the drawings
Fig. 1：Test examining report 1.
Fig. 2：Test examining report 2.
Fig. 3：Test examining report 3.
Fig. 4：Test examining report 4.
Fig. 5：Test examining report 5.
Fig. 6：Test examining report 6.
Fig. 7：Test examining report 7.
Specific embodiment
With reference to embodiment, the present invention is further illustrated.
Involved instrument, reagent, material etc., are existing in the prior art unless otherwise noted in following embodiments
Conventional instrument, reagent, material etc., can be obtained by regular commercial sources.Involved experimental method in following embodiments, inspection
Survey method etc. is existing routine experiment method, detection method etc. in the prior art unless otherwise noted.
Embodiment 1 prepares thimerosal
10000g thimerosals are prepared, group is grouped into：Commercial glucose saccharic acid chlorhexidine（Containing chlorhexidine gluconate 20%）
160g, PVP K30 100g, ethyl alcohol（95% ethyl alcohol）1060g, glycerine（99.5% glycerine）30g, aloe barbadensis Miller liquid
50g, surplus are distilled water.
The aloe barbadensis Miller liquid is the extracting solution of aloe barbadensis Miller, for existing conventional products in the prior art, this hair
Bright used purchased from Shantou City, Guangdong Province, trade name is aloe vera gel, article number DB/T2874.
Preparation method is：Chlorhexidine gluconate or commercially available chlorhexidine gluconate solution are taken, is heated to 80 DEG C, cooling
3 hours, ethyl alcohol is added in, PVP K30, glycerine, aloe barbadensis Miller liquid and distilled water are added after dissolving, is stirred evenly, i.e.,
.Before packing, pH value is adjusted to 8~9（It is adjusted with sodium hydroxide）, bactericidal effect is more preferably.
After testing, the thimerosal of above-mentioned preparation is colourless transparent liquid, and testing inspection is the results detailed in Fig. 1,2.
The experiment of chmice acute Oral toxicity, mice bone marrow micronucleus are carried out respectively, the results showed that：
1st, chmice acute Oral toxicity is tested：Female, male mice LD50Equal ＞ 5000mg/kgBW, the true nontoxic grade in border.
2nd, mice bone marrow micronucleus：Each dosage experiments group is compared with solvent control group, micronucleus cell
There was no significant difference for rate, and result is feminine gender.Testing inspection is the results detailed in Fig. 3,4.
After testing, be respectively provided with bactericidal effect to staphylococcus aureus, Escherichia coli, Candida albicans, opponent, skin without
Irritation, stability is good, 2 years storage periods.Testing inspection is the results detailed in Fig. 5,6,7.
Claims (6)
1. a kind of thimerosal, it is characterised in that：By chlorhexidine gluconate, nonionic surfactant, ethyl alcohol, glycerine, library
Drag-line aloe liquid and water composition, wherein, the mass concentration of chlorhexidine gluconate is 0.25%~0.35%, non-ionic surface active
The mass concentration of agent is 0.9%~1.1%, and the mass concentration of ethyl alcohol is 9%~11%, the mass concentration of glycerine for 0.25%~
0.35%, the mass concentration of aloe barbadensis Miller liquid is 0.45%~0.55%.
2. thimerosal according to claim 1, it is characterised in that：The nonionic surfactant is selected from PVP K30.
3. thimerosal according to claim 1 or 2, it is characterised in that：The thimerosal is by chlorhexidine gluconate, non-
Ionic surface active agent, ethyl alcohol, glycerine, aloe barbadensis Miller liquid and water composition, wherein, the mass concentration of chlorhexidine gluconate
It is 0.30%, the mass concentration of nonionic surfactant is 1.0%, and the mass concentration of ethyl alcohol is 10%, the mass concentration of glycerine
It is 0.230%, the mass concentration of aloe barbadensis Miller liquid is 0.50%.
4. the preparation method of thimerosal according to any one of claims 1 to 3, it is characterised in that：Take chlorhexidine gluconate
Or commercially available chlorhexidine gluconate solution, be heated to 70 DEG C or more, cool down 3 hours, add in ethyl alcohol, added after dissolving it is non-from
Sub- surfactant, glycerine, aloe barbadensis Miller liquid and water, stir evenly to get.
5. preparation method according to claim 4, it is characterised in that：After stirring evenly, adjust pH value to 8~9 to get.
6. thimerosal according to any one of claims 1 to 3 is in environment, space, object table, fabric, fruits and vegetables, hand, skin, the surface of a wound
Application in disinfection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711453382.3A CN108157358A (en) | 2018-03-02 | 2018-03-02 | A kind of thimerosal and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711453382.3A CN108157358A (en) | 2018-03-02 | 2018-03-02 | A kind of thimerosal and preparation method thereof |
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| Publication Number | Publication Date |
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| CN108157358A true CN108157358A (en) | 2018-06-15 |
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| CN201711453382.3A Pending CN108157358A (en) | 2018-03-02 | 2018-03-02 | A kind of thimerosal and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110881471A (en) * | 2018-09-10 | 2020-03-17 | 宝龄富锦生技股份有限公司 | Antimicrobial compositions and methods of making the same |
| WO2021105956A1 (en) * | 2019-11-27 | 2021-06-03 | Lamadrid Nunez Seil Fernando | Disinfectant composition |
| CN113018257A (en) * | 2021-03-03 | 2021-06-25 | 西安蓝茗医疗科技有限公司 | Alkalescent skin mucosa cleaning disinfectant and preparation method thereof |
| CN115119849A (en) * | 2022-07-02 | 2022-09-30 | 厦门迈诺泰医疗科技有限公司 | Decontamination disinfectant for appliances and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110881471A (en) * | 2018-09-10 | 2020-03-17 | 宝龄富锦生技股份有限公司 | Antimicrobial compositions and methods of making the same |
| WO2021105956A1 (en) * | 2019-11-27 | 2021-06-03 | Lamadrid Nunez Seil Fernando | Disinfectant composition |
| CN113018257A (en) * | 2021-03-03 | 2021-06-25 | 西安蓝茗医疗科技有限公司 | Alkalescent skin mucosa cleaning disinfectant and preparation method thereof |
| CN115119849A (en) * | 2022-07-02 | 2022-09-30 | 厦门迈诺泰医疗科技有限公司 | Decontamination disinfectant for appliances and preparation method thereof |
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