CN104435604A - Preparation method of Chinese herbal medicine skin mucosa disinfectant - Google Patents
Preparation method of Chinese herbal medicine skin mucosa disinfectant Download PDFInfo
- Publication number
- CN104435604A CN104435604A CN201410700209.9A CN201410700209A CN104435604A CN 104435604 A CN104435604 A CN 104435604A CN 201410700209 A CN201410700209 A CN 201410700209A CN 104435604 A CN104435604 A CN 104435604A
- Authority
- CN
- China
- Prior art keywords
- parts
- herbal medicine
- chinese herbal
- skin mucosa
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a preparation method of a Chinese herbal medicine skin mucosa disinfectant. The preparation method comprises the following steps: weighing 10 to 20 parts of baikal skullcap root, 10 to 20 parts of honey suckle, 10 to 20 parts of grapefruit, 5 to 10 parts of aloe, and 3 to 5 parts of lavandula angustifolia, adding the raw materials into ethyl alcohol, so as to be extracted and filtered, performing decoloration on filtrate, contracting the filtrate to the volume being 0.3 times of the original volume, so as to be standby, weighing 5 to 10 parts of garlic, adding glycollic acid to grind and filter the garlic, ensuring that filtrate is standby, then weighing 3 to 5 parts of mentha camphor, 1 to 3 parts of glycerin, 1 to 3 parts of chitosan quaternary ammonium salt, 0.2 to 0.5 part of alkyl dimethyl benzyl ammonium chloride, and 5 to 10 parts of palmitic acid sucrose ester, adding distilled water to the raw materials to dissolve the raw materials, combining the prepared liquid, and stirring the liquid to obtain the Chinese herbal medicine skin mucosa disinfectant. The Chinese herbal medicine skin mucosa disinfectant prepared by the method does not have pungent smell, is low in toxicity, weak in irritation to skin mucosa and eyes, and pollution-free for the environment, and improves the sterilization and disinfection effects because of the mating reaction between Chinese herbal medicine and disinfection active constituents.
Description
Technical field
The present invention relates to disinfection technology field, particularly a kind of preparation method of Chinese herbal medicine skin mucosa disinfectant.
Background technology
Protecting human body gets up by skin and mucosa, and making human body define an airtight system to external world, when harmful substance will invade human body, is first that extraneous paathogenic factor is blocked in external by skin and mucosa.So skin and mucosa are human body anti-infective the first line of defences.Therefore the sterilization outbalance of skin mucosa.
At present, skin mucosa disinfectant preparation mainly contains: 1, peracetic acid, peracetic acid mainly relies on its Strong oxdiative ability to the killing action of microorganism, it can destroy the permeability barrier of bacterial spore, and then destroy and dissolve core, the material damage of DNA, RNA, protein is spilt, causes spore dead.Peracetic acid is usually used in by virus contamination article or skin degerming, and during general sterilisation of objects, usable concentration is 0.5%, and during skin degerming, usable concentration is 0.2%-0.4%, and action time is 3 minutes.But Organic substance can reduce the bactericidal action of peracetic acid, needed for the thin rice seedling brood body killing 20% serum protection, peroxyacetic acid concentration need increase by 4 ~ 15 times, and need increase by 2 ~ 3 times to bacterial spore.Peracetic acid soln is unstable, need be placed in ventilating and cooling place during storage, first measures valid density altogether with front; With distilled water, deionized water or pure water prepared and diluted liquid, preserve no more than 48h under diluent room temperature.Peracetic acid has very strong corrosivity to metal, acutely decomposes, even blast when having bases or Organic substance to be mixed into.The medicinal liquid of high concentration has severe corrosive and zest, and its abnormal smells from the patient people is beyond affordability.2, alcohol disinfectant: 1. ethanol belongs to middle effect disinfectants, bactericidal action is very fast, and non-stimulated to human body, toxicity is less.Ethanol sterilization there are certain requirements concentration, and its effective volume fraction should be 65% ~ 75%.Water to ethanol play bactericidal action very necessary, need dilute ethanol time therefore for sterilizing, but concentration lower than 30% time bactericidal action very little, concentration is crossed strong or excessively weak, and bactericidal action all can reduce.The folk prescription ethanol disinfection preparation of 75% to human non-toxic, but due to the body constitution of people different, one or two people are irritated to ethanol, can cause erythra, erythema after contact.Ethanol disinfection preparation often uses, skin therefore can produce defat and drying, the phenomenon such as coarse.2. isopropyl alcohol: the bactericidal action of isopropyl alcohol is better than ethanol.But it belongs to slight noxious substance, when exceeding finite concentration, there is intense stimulus effect to respiratory mucosa and eye conjunctiva, and cell tissue can be caused downright bad.Aqueous isopropanol is by force fat dissolving, repeatedly contacts skin and can make xerosis cutis defat.In addition, Organic substance and low temperature all can make the bactericidal effect of isopropyl alcohol weaken.3, iodine-containing disinfectant: common ground povidone iodine and iodine tincture.Their halogenation microproteins of relying make it dead.Can kill vegetative forms of bacteria, fungus and fractionated viral.May be used for skin, mucosa sterilization, hospital is usually used in surgical hand sterilization.The working concentration of general iodine tincture is 2%, and povidone iodine working concentration is 0.3% to 0.5%.But iodide ion is extremely active, its oxidizing force is very strong, is a kind of material of instability, can reduce effective content and reduce disinfective action.And these disinfectant liquid for skin are mostly synthetics, as Iodic agent, alcohol disinfectant etc., the general poor stability of these materials, large to human body zest, life-time service has certain potential hazard to human body.
One section of publication number is the preparation method of a CN1182533 composite type medical disinfectant, it is by glutaraldehyde, Radix Glycyrrhizae derivant, non-ionic surface active agent, essence, deionized water forms, this disinfectant can be directly used in the washing of various trauma patient, sterilization, simultaneously to the sterilization of medical worker's operation consent, the sterilization of various medical apparatus and instruments, the sterilization of hygienic article all has function and the cleaning function of very strong killing pathogenic bacteria, simultaneously main is have promotion wound, the effect of healing, this disinfectant chemical stabilization, safety is high, without any side effects to human body skin.Glutaraldehyde is wherein the colourless transparent oil liquid with penetrating odor, is dissolved in hot water, has strong impulse effect to eyes, skin and mucosa, although bactericidal effect is good, is not suitable for the sterilization of skin and mucosa.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of Chinese herbal medicine skin mucosa disinfectant, this disinfectant liquid for skin prepared by the method can effectively sterilize comprehensively, little to skin irritation, toxicity is little, uses rear skin moist, is applicable to the sterilization of skin mucosa.
For solving the problems of the technologies described above, the present invention is achieved through the following technical solutions.
A kind of preparation method of Chinese herbal medicine skin mucosa disinfectant, prepare in the steps below: (1) takes Radix Scutellariae 10-20 part, Flos Lonicerae 10-20 part, grapefruit 10-20 part, Aloe 5-10 part, lavandula angustifolia 3-5 part, add the ethanol of 6-8 times amount, at 70-80 DEG C, extract 30-35min, filter, medicinal residues add the ethanol extraction 20-25min of 4-5 times amount again, filter, merging filtrate, adds activated carbon decolorizing, filter, filtrate distillation and concentration is for subsequent use to 0.3 times of original volume;
(2) take Bulbus Allii 5-10 part, the ethanol adding appropriate 60%-70% fully grinds, and filter, filtrate is for subsequent use;
(3) Mentholum 3-5 part, glycerol 1-3 part, chitosan quaternary ammonium salt 1-3 part is taken, zephiran 0.2-0.5 part, Palmic acid sucrose ester 5-10 part, adding distil water stirring and dissolving;
(4) liquid that step (2) agent step (3) is obtained is joined in the concentrated solution in step (1), be uniformly mixed dissolving and namely obtain Chinese herbal medicine skin mucosa disinfectant.
Preferably, in the process of lapping of Bulbus Allii, add the white vinegar of 0.5-1 part.
Preferably, Bulbus Allii grinding is the ethanol grinding adding 0.5-1 times amount
In described step (3), the addition of distilled water is 150-180 part.
Described Bulbus Allii is only head purple garlic.
Described Bulbus Allii is the Bulbus Allii slurry that fresh garlic is worn into.
Described grapefruit is the sarcocarp after squeezing the juice in the Renhe of grapefruit.
Beneficial effect:
1, the present invention adopts Chinese herbal medicine and chitosan quaternary ammonium salt, zephiran, the composite sterilization component as this disinfectant liquid for skin, decrease the use amount of chemical bactericide, each pathogenic bacteria can be effectively killed while greatly reducing the toxicity of disinfectant solution, wherein each composition composite obtain skin irritation little, be particularly suitable for the sterilizing of skin mucosa, in addition, chitosan quaternary ammonium salt and zephiran is selected to share, there is synergism, the bactericidal action of chitosan quaternary ammonium salt can be improved; Containing grapefruit in the present invention, grapefruit extract can effectively kill all kinds of pathogenic bacteria, has effect of moisturizing and anti-inflammation simultaneously, contribute to the healing of skin wound in the present invention containing Aloe, lavandula angustifolia extracting solution has cleaning skin, anti-inflammatory efficacy, can prevention infection and inflammation effect; , light anaesthesia can also be played and do in order to detumescence pain; Palmic acid sucrose ester in the present invention can promote medicinal herb components dissolubility and improve the effect of bactericidal effect, is be made up of sucrose and oils and fats, tasteless, nontoxic, and energy biodegradation, not chafe, do not pollute the environment
So the disinfectant solution adopting method of the present invention to prepare does not have penetrating odor, toxicity low, weak to the zest of skin mucosa and eyes, environmentally safe.Simultaneously due to the mating reaction of antimicrobial activity composition, improve disinfection effect, increase germicidal efficiency.
2, the present invention adopts only head purple garlic, and containing more sterilization component, bactericidal effect is good, and the bactericidal action adding white vinegar and Bulbus Allii has collaborative effect, strengthens bactericidal effect.Grapefruit raw material in the present invention is the sarcocarp selecting the Renhe of grapefruit to squeeze juice, and raw material is cheap and easy to get.
Detailed description of the invention
The present invention is further illustrated below by detailed description of the invention.
Embodiment 1
A kind of preparation method of Chinese herbal medicine skin mucosa disinfectant, prepare in the steps below: (1) takes Radix Scutellariae 10 parts, Flos Lonicerae 10 parts, grapefruit 10 parts, Aloe 5 parts, lavandula angustifolia 3 parts, add the ethanol of 6 times amount, at 70 DEG C, extract 30min, filter, medicinal residues add the ethanol extraction 20min of 4 times amount again, filter, merging filtrate, adds activated carbon decolorizing, filter, filtrate distillation and concentration is for subsequent use to 0.3 times of original volume;
(2) take 5 parts, Bulbus Allii, the ethanol adding appropriate 60% fully grinds, and filter, filtrate is for subsequent use;
(3) Mentholum 3 parts, glycerol 1 part, chitosan quaternary ammonium salt 1 part is taken, zephiran 0.2 part, Palmic acid sucrose ester 5 parts, adding distil water stirring and dissolving;
(4) liquid that step (2) agent step (3) is obtained is joined in the concentrated solution in step (1), be uniformly mixed dissolving and namely obtain Chinese herbal medicine skin mucosa disinfectant.
Embodiment 2
A kind of preparation method of Chinese herbal medicine skin mucosa disinfectant, prepare in the steps below: (1) takes Radix Scutellariae 15 parts, Flos Lonicerae 15 parts, grapefruit 15 parts, Aloe 8 parts, lavandula angustifolia 4 parts, add the ethanol of 7 times amount, at 75 DEG C, extract 35min, filter, medicinal residues add the ethanol extraction 20min of 4 times amount again, filter, merging filtrate, adds activated carbon decolorizing, filter, filtrate distillation and concentration is for subsequent use to 0.3 times of original volume;
(2) take 8 parts, Bulbus Allii, the ethanol adding appropriate 60% fully grinds, and filter, filtrate is for subsequent use;
(3) Mentholum 4 parts, glycerol 2 parts, chitosan quaternary ammonium salt 2 parts is taken, zephiran 0.4 part, Palmic acid sucrose ester 7 parts, adding distil water stirring and dissolving;
(4) liquid that step (2) agent step (3) is obtained is joined in the concentrated solution in step (1), be uniformly mixed dissolving and namely obtain Chinese herbal medicine skin mucosa disinfectant.
Embodiment 3
A kind of preparation method of Chinese herbal medicine skin mucosa disinfectant, prepare in the steps below: (1) takes Radix Scutellariae 20 parts, Flos Lonicerae 20 parts, grapefruit 20 parts, Aloe 10 parts, lavandula angustifolia 5 parts, add the ethanol of 8 times amount, at 75 DEG C, extract 30min, filter, medicinal residues add the ethanol extraction 25min of 5 times amount again, filter, merging filtrate, adds activated carbon decolorizing, filter, filtrate distillation and concentration is for subsequent use to 0.3 times of original volume;
(2) take 10 parts, Bulbus Allii, the ethanol adding appropriate 70% fully grinds, and filter, filtrate is for subsequent use;
(3) Mentholum 5 parts, glycerol 3 parts, chitosan quaternary ammonium salt 3 parts is taken, zephiran 0.5 part, Palmic acid sucrose ester 10 parts, adding distil water stirring and dissolving;
(4) liquid that step (2) agent step (3) is obtained is joined in the concentrated solution in step (1), be uniformly mixed dissolving and namely obtain Chinese herbal medicine skin mucosa disinfectant.
Embodiment 4
A kind of preparation method of Chinese herbal medicine skin mucosa disinfectant, prepare in the steps below: (1) takes Radix Scutellariae 12 parts, Flos Lonicerae 12 parts, grapefruit 12 parts, Aloe 7 parts, lavandula angustifolia 4 parts, add the ethanol of 7 times amount, at 75 DEG C, extract 32min, filter, medicinal residues add the ethanol extraction 20min of 5 times amount again, filter, merging filtrate, adds activated carbon decolorizing, filter, filtrate distillation and concentration is for subsequent use to 0.3 times of original volume;
(2) take 6 parts, Bulbus Allii, the ethanol adding appropriate 65% fully grinds, and filter, filtrate is for subsequent use;
(3) Mentholum 4 parts, glycerol 2 parts, chitosan quaternary ammonium salt 2 parts is taken, zephiran 0.4 part, Palmic acid sucrose ester 7 parts, adding distil water stirring and dissolving;
(4) liquid that step (2) agent step (3) is obtained is joined in the concentrated solution in step (1), be uniformly mixed dissolving and namely obtain Chinese herbal medicine skin mucosa disinfectant.Preferably, in the process of lapping of Bulbus Allii, add the white vinegar of 0.5-1 part.Preferably, the ethanol grinding of 0.5-1 times amount is added during Bulbus Allii grinding.
Embodiment 5
A kind of preparation method of Chinese herbal medicine skin mucosa disinfectant, prepare in the steps below: (1) takes Radix Scutellariae 18 parts, Flos Lonicerae 18 parts, grapefruit 18 parts, Aloe 9 parts, lavandula angustifolia 5 parts, add the ethanol of 7 times amount, at 75 DEG C, extract 30min, filter, medicinal residues add the ethanol extraction 25min of 5 times amount again, filter, merging filtrate, adds activated carbon decolorizing, filter, filtrate distillation and concentration is for subsequent use to 0.3 times of original volume;
(2) take 9 parts, Bulbus Allii, the ethanol adding appropriate 65% fully grinds, and filter, filtrate is for subsequent use;
(3) Mentholum 4 parts, glycerol 2 parts, chitosan quaternary ammonium salt 3 parts is taken, zephiran 0.4 part, Palmic acid sucrose ester 9 parts, adding distil water stirring and dissolving;
(4) liquid that step (2) agent step (3) is obtained is joined in the concentrated solution in step (1), be uniformly mixed dissolving and namely obtain Chinese herbal medicine skin mucosa disinfectant.In the present embodiment, Bulbus Allii adopts only head purple garlic.The Bulbus Allii slurry preferably adopting fresh Bulbus Allii to wear into.Grapefruit can squeeze the juice with the Renhe of grapefruit after sarcocarp.
Embodiment 6
A kind of preparation method of Chinese herbal medicine skin mucosa disinfectant, prepare in the steps below: (1) takes Radix Scutellariae 15 parts, Flos Lonicerae 15 parts, grapefruit 15 parts, Aloe 8 parts, lavandula angustifolia 4 parts, add the ethanol of 7 times amount, at 75 DEG C, extract 35min, filter, medicinal residues add the ethanol extraction 20min of 4 times amount again, filter, merging filtrate, adds activated carbon decolorizing, filter, filtrate distillation and concentration is for subsequent use to 0.3 times of original volume;
(2) take 8 parts, Bulbus Allii, the ethanol adding appropriate 60% fully grinds, and filter, filtrate is for subsequent use;
(3) Mentholum 4 parts, glycerol 2 parts, chitosan quaternary ammonium salt 2 parts is taken, zephiran 0.4 part, Palmic acid sucrose ester 7 parts, adding distil water stirring and dissolving;
(4) liquid that step (2) agent step (3) is obtained is joined in the concentrated solution in step (1), be uniformly mixed dissolving and namely obtain Chinese herbal medicine skin mucosa disinfectant.In step (3), addition 150-180 part of distilled water as well.
Claims (7)
1. the preparation method of a Chinese herbal medicine skin mucosa disinfectant, it is characterized in that: prepare in the steps below: (1) takes Radix Scutellariae 10-20 part, Flos Lonicerae 10-20 part, grapefruit 10-20 part, Aloe 5-10 part, lavandula angustifolia 3-5 part, add the ethanol of 6-8 times amount, at 70-80 DEG C, extract 30-35min, filter, medicinal residues add the ethanol extraction 20-25min of 4-5 times amount again, filter, merging filtrate, adds activated carbon decolorizing, filter, filtrate distillation and concentration is for subsequent use to 0.3 times of original volume;
(2) take Bulbus Allii 5-10 part, the ethanol adding appropriate 60%-70% fully grinds, and filter, filtrate is for subsequent use;
(3) Mentholum 3-5 part, glycerol 1-3 part, chitosan quaternary ammonium salt 1-3 part is taken, zephiran 0.2-0.5 part, Palmic acid sucrose ester 5-10 part, adding distil water stirring and dissolving;
(4) liquid that step (2) agent step (3) is obtained is joined in the concentrated solution in step (1), be uniformly mixed dissolving and namely obtain Chinese herbal medicine skin mucosa disinfectant.
2. the preparation method of a kind of Chinese herbal medicine skin mucosa disinfectant according to claim 1, is characterized in that: the white vinegar adding 0.5-1 part in the process of lapping of Bulbus Allii.
3. the preparation method of a kind of Chinese herbal medicine skin mucosa disinfectant according to claim 1, is characterized in that: Bulbus Allii grinding is the ethanol grinding adding 0.5-1 times amount.
4. the preparation method of a kind of Chinese herbal medicine skin mucosa disinfectant according to claim 1, is characterized in that: in described step (3), the addition of distilled water is 150-180 part.
5. the preparation method of a kind of Chinese herbal medicine skin mucosa disinfectant according to claim 1, is characterized in that: described Bulbus Allii is only head purple garlic.
6. the preparation method of a kind of Chinese herbal medicine skin mucosa disinfectant according to claim 1, is characterized in that: described Bulbus Allii is the Bulbus Allii slurry that fresh garlic is worn into.
7. the preparation method of a kind of Chinese herbal medicine skin mucosa disinfectant according to claim 1, is characterized in that: described grapefruit is the sarcocarp after squeezing the juice in the Renhe of grapefruit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410700209.9A CN104435604A (en) | 2014-11-28 | 2014-11-28 | Preparation method of Chinese herbal medicine skin mucosa disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410700209.9A CN104435604A (en) | 2014-11-28 | 2014-11-28 | Preparation method of Chinese herbal medicine skin mucosa disinfectant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104435604A true CN104435604A (en) | 2015-03-25 |
Family
ID=52882865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410700209.9A Pending CN104435604A (en) | 2014-11-28 | 2014-11-28 | Preparation method of Chinese herbal medicine skin mucosa disinfectant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104435604A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214821A (en) * | 2016-08-31 | 2016-12-14 | 宋克玉 | A kind of clinical laboratory disinfection solution |
| CN108815351A (en) * | 2018-07-11 | 2018-11-16 | 合肥华盖生物科技有限公司 | A kind of efficient and environment-friendly type thimerosal and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1548035A (en) * | 2003-05-21 | 2004-11-24 | 哈药集团三精制药有限公司 | Washing skin care article of honeysuckle and skullcap root |
| JP2007119366A (en) * | 2005-10-26 | 2007-05-17 | Shunkosha:Kk | Method for sterilizing trichophyton |
| CN102488705A (en) * | 2011-12-08 | 2012-06-13 | 施耐克江苏生物制药有限公司 | Skin mucous membrane disinfectant for killing virus |
| CN103816089A (en) * | 2014-03-11 | 2014-05-28 | 广州市洋林生物科技开发有限公司 | Skin mucous menbrane antimicrobial fluid and skin mucous menbrane antimicrobial wet tissue |
| CN103933275A (en) * | 2014-03-27 | 2014-07-23 | 张建民 | Antibacterial disinfection medicament and preparation method thereof |
-
2014
- 2014-11-28 CN CN201410700209.9A patent/CN104435604A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1548035A (en) * | 2003-05-21 | 2004-11-24 | 哈药集团三精制药有限公司 | Washing skin care article of honeysuckle and skullcap root |
| JP2007119366A (en) * | 2005-10-26 | 2007-05-17 | Shunkosha:Kk | Method for sterilizing trichophyton |
| CN102488705A (en) * | 2011-12-08 | 2012-06-13 | 施耐克江苏生物制药有限公司 | Skin mucous membrane disinfectant for killing virus |
| CN103816089A (en) * | 2014-03-11 | 2014-05-28 | 广州市洋林生物科技开发有限公司 | Skin mucous menbrane antimicrobial fluid and skin mucous menbrane antimicrobial wet tissue |
| CN103933275A (en) * | 2014-03-27 | 2014-07-23 | 张建民 | Antibacterial disinfection medicament and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 古一雯等: "消毒剂研究新进展", 《中医消毒学杂志》 * |
| 王德斌等: "《资源生物学》", 30 September 2008, 云南科技出版社 * |
| 高学敏: "《中药学》", 30 September 2002, 中国中医药出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106214821A (en) * | 2016-08-31 | 2016-12-14 | 宋克玉 | A kind of clinical laboratory disinfection solution |
| CN108815351A (en) * | 2018-07-11 | 2018-11-16 | 合肥华盖生物科技有限公司 | A kind of efficient and environment-friendly type thimerosal and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106334067B (en) | Gynecological gel containing silver ion antibacterial agent, preparation method and application | |
| US20150264935A1 (en) | Semi-Fluidic Composition for Lubricating, Moisture Retaining, Disinfecting, Sterilizing and Method Using the Same | |
| JP2008534675A (en) | Antibacterial composition containing natural extract, nanosilver, and natural essential oil | |
| KR20160079473A (en) | Preparation method of cleaning or disinfecting composition having antiviral activity by containing green tea extract as active component | |
| WO2011139794A2 (en) | A composition for skin sanitization and protection and method of its use | |
| KR20120063036A (en) | Method for manufacturing handwash and handwash composition thereof containing natural oriental plant extracts | |
| CN105362351A (en) | Medicine composition for treating cutaneous pruritus disease and application thereof | |
| KR102366247B1 (en) | Wet wipe composition and its manufacturing method | |
| CN107028848A (en) | A kind of disinfection solution of disposable hand natural green | |
| CN104435607A (en) | Chinese herbal medicine skin mucosa disinfectant | |
| CN106924162A (en) | A kind of application of plant additive, bacteriostatic agent, oral care product and plant additive in oral care product is prepared | |
| CN102327343B (en) | External essential oil formula for preventing and treating beriberi | |
| CN104523466A (en) | Chinese herbal medicinal skin mucosa disinfection wet wipe | |
| CN111493097A (en) | Collective disinfectant for inhibiting viruses and pathogenic bacteria and preparation method thereof | |
| KR100947282B1 (en) | Composition of environmental antiseptic | |
| CN105030613B (en) | A kind of natural plant essential oils foot lotion of antibacterial fatigue-relieving | |
| CN103933275A (en) | Antibacterial disinfection medicament and preparation method thereof | |
| CN104435604A (en) | Preparation method of Chinese herbal medicine skin mucosa disinfectant | |
| CN107137273A (en) | A kind of oral nursing liquid | |
| CN103110541A (en) | All-natural washing-free disinfectant hand sanitizer | |
| CN104435605A (en) | Preparation method of Chinese herbal medicine skin disinfectant | |
| CN104434994A (en) | Mucocutaneous disinfectant | |
| CN105796769A (en) | Medical wound disinfection solution and preparation method thereof | |
| CN104488993A (en) | Disinfectant | |
| CN110946159A (en) | Plant essence biological compound clothing mildew sweat odor removing agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150325 |
|
| RJ01 | Rejection of invention patent application after publication |