CN104490633A - Skin mucous membrane disinfection wet wipe - Google Patents
Skin mucous membrane disinfection wet wipe Download PDFInfo
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- CN104490633A CN104490633A CN201410700142.9A CN201410700142A CN104490633A CN 104490633 A CN104490633 A CN 104490633A CN 201410700142 A CN201410700142 A CN 201410700142A CN 104490633 A CN104490633 A CN 104490633A
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Abstract
The invention provides a skin mucous membrane disinfection wet wipe. The skin mucous membrane disinfection wet wipe comprises a sterile non-woven fabric and a disinfectant carried by the sterile non-woven fabric. A preparation method of the disinfectant comprises the following steps of 1, weighing 8 parts of chitosan quaternary ammonium salt, 4 parts of alkyldimethyl benzylammonium chloride, 8 parts of sodium nonylphenol polyoxyethylene ether sulfate, 4 parts of beeswax, 8 parts of povidone iodine, 4 parts of dipotassium glycyrrhizinate, 4 parts of a surfactant, 2 parts of urea and 40 parts of deionized water, 2, stirring the sodium nonylphenol polyoxyethylene ether sulfate, surfactant, beeswax and deionized water weighed by the step 1 to obtain a uniform mixture, adding the chitosan quaternary ammonium salt, alkyldimethyl benzylammonium chloride, povidone iodine, dipotassium glycyrrhizinate and urea weighed by the step 1 into the mixture, carrying out stirring for complete dissolution and adjusting a PH value to 7-9. The skin mucous membrane disinfection wet wipe has no excitant smell, low toxicity and low irritation to the skin mucous membrane. Through cooperation action of disinfection active components, sterilization disinfection effects are improved.
Description
Technical field
The present invention relates to disinfection technology field, particularly a kind of skin mucosa pasteurization towelette.
Background technology
Protecting human body gets up by skin and mucosa, and making human body define an airtight system to external world, when harmful substance will invade human body, is first that extraneous paathogenic factor is blocked in external by skin and mucosa.So skin and mucosa are human body anti-infective the first line of defences.Therefore the sterilization outbalance of skin mucosa.
At present, skin mucosa disinfectant preparation mainly contains: 1, peracetic acid, peracetic acid mainly relies on its Strong oxdiative ability to the killing action of microorganism, it can destroy the permeability barrier of bacterial spore, and then destroy and dissolve core, the material damage of DNA, RNA, protein is spilt, causes spore dead.Peracetic acid is usually used in by virus contamination article or skin degerming, and during general sterilisation of objects, usable concentration is 0.5%, and during skin degerming, usable concentration is 0.2%-0.4%, and action time is 3 minutes.But Organic substance can reduce the bactericidal action of peracetic acid, needed for the thin rice seedling brood body killing 20% serum protection, peroxyacetic acid concentration need increase by 4 ~ 15 times, and need increase by 2 ~ 3 times to bacterial spore.Peracetic acid soln is unstable, need be placed in ventilating and cooling place during storage, first measures valid density altogether with front; With distilled water, deionized water or pure water prepared and diluted liquid, preserve no more than 48h under diluent room temperature.Peracetic acid has very strong corrosivity to metal, acutely decomposes, even blast when having bases or Organic substance to be mixed into.The medicinal liquid of high concentration has severe corrosive and zest, and its abnormal smells from the patient people is beyond affordability.2, alcohol disinfectant: 1. ethanol belongs to middle effect disinfectants, bactericidal action is very fast, and non-stimulated to human body, toxicity is less.Ethanol sterilization there are certain requirements concentration, and its effective volume fraction should be 65% ~ 75%.Water to ethanol play bactericidal action very necessary, need dilute ethanol time therefore for sterilizing, but concentration lower than 30% time bactericidal action very little, concentration is crossed strong or excessively weak, and bactericidal action all can reduce.The folk prescription ethanol disinfection preparation of 75% to human non-toxic, but due to the body constitution of people different, one or two people are irritated to ethanol, can cause erythra, erythema after contact.Ethanol disinfection preparation often uses, skin therefore can produce defat and drying, the phenomenon such as coarse.2. isopropyl alcohol: the bactericidal action of isopropyl alcohol is better than ethanol.But it belongs to slight noxious substance, when exceeding finite concentration, there is intense stimulus effect to respiratory mucosa and eye conjunctiva, and cell tissue can be caused downright bad.Aqueous isopropanol is by force fat dissolving, repeatedly contacts skin and can make xerosis cutis defat.In addition, Organic substance and low temperature all can make the bactericidal effect of isopropyl alcohol weaken.3, iodine-containing disinfectant: common ground povidone iodine and iodine tincture.Their halogenation microproteins of relying make it dead.Can kill vegetative forms of bacteria, fungus and fractionated viral.May be used for skin, mucosa sterilization, hospital is usually used in surgical hand sterilization.The working concentration of general iodine tincture is 2%, and povidone iodine working concentration is 0.3% to 0.5%.But iodide ion is extremely active, its oxidizing force is very strong, is a kind of material of instability, can reduce effective content and reduce disinfective action.
One section of notification number is disclose a kind of pasteurization towelette and preparation method thereof in the patent document of CN1415203, after the pasteurization towelette of this invention is mixed with aqueous solution of chlorine dioxide by Folium Ilicis Purpureae water extract, then forms with sterilizing non-woven fabrics dipping; Pasteurization towelette all has good bactericidal effect to escherichia coli, staphylococcus aureus, its sterilizing rate is high, and shelf characteric is stablized, long shelf-life, non-stimulated to skin, to the reaction of skin ametaboly, its matter is soft thick, soft, use safety, be easy to carry, be applicable to multiple place, be people's daily life and tourism time the good hygienic article of one.This wet tissue contains chlorine dioxide, and chlorine-containing disinfectant has obvious stimulation to the respiratory mucosa of people and skin, can draw tears from sb, cough, and chafe and mucosa, severe patient can make people produce chlorine poisoning.
Summary of the invention
The object of the present invention is to provide a kind of skin mucosa pasteurization towelette, adopt this pasteurization towelette effectively to sterilize comprehensively, little to skin irritation, use rear skin moist, be applicable to the sterilization of skin mucosa.
For solving the problems of the technologies described above, the present invention is achieved through the following technical solutions.
A kind of skin mucosa pasteurization towelette, comprise sterilizing non-woven fabrics, the disinfectant be carried on sterilizing non-woven fabrics, described disinfectant is prepared in the steps below: (1) takes chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, 4 parts, Cera Flava, povidone iodine 8 parts, glycyrrhizic acid dipotassium 4 parts, 4 parts, surfactant; 2 parts, carbamide, deionized water 40 parts are for subsequent use;
(2) nonylphenol polyoxyethylene ether sulfate taken in step (1) and surfactant, Cera Flava are added in container stir, then add in step (1) and take the stirring of chitosan quaternary ammonium salt, zephiran, povidone iodine, glycyrrhizic acid dipotassium and carbamide makes it dissolve completely, add the deionized water in step (1), regulate PH to be 7-9 and to get final product.
Described skin mucosa pasteurization towelette sterilizing non-woven fabrics is placed in above-mentioned disinfectant to soak and obtain for 1-2 hour, keeps temperature to be 30-35 DEG C during immersion.
Described step (2) operates at 30-35 DEG C.
Described Cera Flava first melts before addition.
Described chitosan quaternary ammonium salinity is 1.5mg/ml.
Described chitosan quaternary ammonium salt is N – N-propyl-N, N-dimethyl chitosan.
Described surfactant be CH3-(CH2)13N(CH3)2-O, octyl phenol polyoxyethylene, myristyl dimethyl amine oxide one or more.
Beneficial effect:
1, pasteurization towelette of the present invention selects the composite sterilization component as this skin mucosa pasteurization towelette of these four kinds of materials of chitosan quaternary ammonium salt, zephiran, povidone iodine, can effectively kill each pathogenic bacteria, wherein each composition composite obtain skin irritation little, be particularly suitable for the sterilizing of skin mucosa, containing glycyrrhizic acid dipotassium in disinfectant of the present invention, glycyrrhizic acid dipotassium not only has certain antibacterial and anti-inflammation functions, can also noxious substance be adsorbed, antibacterial can be reduced and grow at skin surface; In addition, adopt chitosan quaternary ammonium salt and zephiran to share, there is synergism, the bactericidal action of chitosan quaternary ammonium salt can be improved; Nonylphenol polyoxyethylene ether sulfate has a certain amount of epoxy radicals and sulfate, therefore it has nonionic and anion surfactant double properties concurrently, clean clean effect is good, also very little to the zest of skin, skin can be made to moisten containing Cera Flava in the present invention moist, and Cera Flava has the circulation and activating cell that promote skin blood, and there is the effect of antiinflammatory, particularly to there being wound to have astriction; Carbamide in the present invention has the effect of stabilizing agent, share simultaneously, play the effect to skin moisture-keeping with Cera Flava.
So skin mucosa pasteurization towelette of the present invention does not have penetrating odor, toxicity low, weak to the zest of skin mucosa and eyes, environmentally safe.Simultaneously due to the mating reaction of antimicrobial activity composition, improve disinfection effect.
2, the disinfectant of pasteurization towelette of the present invention in the preparation, to each composition mix and blend of disinfectant solution at 30-35 DEG C, increases the dissolubility of sterilization component, increase disinfectant solution bactericidal effect.Cera Flava first melts before mixing with other each compositions, make Cera Flava can with equal because of mix with other compositions, shorten mixing time.
Detailed description of the invention
The present invention is further illustrated below by detailed description of the invention.
Embodiment 1
A kind of skin mucosa pasteurization towelette, comprise sterilizing non-woven fabrics, the disinfectant be carried on sterilizing non-woven fabrics, described disinfectant is prepared in the steps below: (1) takes chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, 4 parts, Cera Flava, povidone iodine 8 parts, glycyrrhizic acid dipotassium 4 parts, 4 parts, surfactant; 2 parts, carbamide, deionized water 40 parts are for subsequent use;
(2) nonylphenol polyoxyethylene ether sulfate taken in step (1) and surfactant, Cera Flava are added in container stir, then add in step (1) and take the stirring of chitosan quaternary ammonium salt, zephiran, povidone iodine, glycyrrhizic acid dipotassium and carbamide makes it dissolve completely, add the deionized water in step (1), regulate PH to be 7 and to get final product.
Described skin mucosa pasteurization towelette sterilizing non-woven fabrics is placed in above-mentioned disinfectant to soak and obtain for 1-2 hour, keeps temperature to be 30-35 DEG C during immersion.
Embodiment 2
A kind of skin mucosa pasteurization towelette, comprise sterilizing non-woven fabrics, the disinfectant be carried on sterilizing non-woven fabrics, described disinfectant is prepared in the steps below: (1) takes chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, 4 parts, Cera Flava, povidone iodine 8 parts, glycyrrhizic acid dipotassium 4 parts, 4 parts, surfactant; 2 parts, carbamide, deionized water 40 parts are for subsequent use;
(2) nonylphenol polyoxyethylene ether sulfate taken in step (1) and surfactant, Cera Flava are added in container stir, then add in step (1) and take the stirring of chitosan quaternary ammonium salt, zephiran, povidone iodine, glycyrrhizic acid dipotassium and carbamide makes it dissolve completely, add the deionized water in step (1), regulate PH to be 7-9 and to get final product.Described step (2) operates at 30-35 DEG C.
Embodiment 3
A kind of skin mucosa pasteurization towelette, comprise sterilizing non-woven fabrics, the disinfectant be carried on sterilizing non-woven fabrics, described disinfectant is prepared in the steps below: (1) takes chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, 4 parts, Cera Flava, povidone iodine 8 parts, glycyrrhizic acid dipotassium 4 parts, 4 parts, surfactant; 2 parts, carbamide, deionized water 40 parts are for subsequent use;
(2) nonylphenol polyoxyethylene ether sulfate taken in step (1) and surfactant, Cera Flava are added in container stir, then add in step (1) and take the stirring of chitosan quaternary ammonium salt, zephiran, povidone iodine, glycyrrhizic acid dipotassium and carbamide makes it dissolve completely, add the deionized water in step (1), regulate PH to be 7-9 and to get final product.
Described Cera Flava first melts before addition.
Embodiment 4
A kind of skin mucosa pasteurization towelette, comprise sterilizing non-woven fabrics, the disinfectant be carried on sterilizing non-woven fabrics, described disinfectant is prepared in the steps below: (1) takes chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, 4 parts, Cera Flava, povidone iodine 8 parts, glycyrrhizic acid dipotassium 4 parts, 4 parts, surfactant; 2 parts, carbamide, deionized water 40 parts are for subsequent use;
(2) nonylphenol polyoxyethylene ether sulfate taken in step (1) and surfactant, Cera Flava are added in container stir, then add in step (1) and take the stirring of chitosan quaternary ammonium salt, zephiran, povidone iodine, glycyrrhizic acid dipotassium and carbamide makes it dissolve completely, add the deionized water in step (1), regulate PH to be 7-9 and to get final product.
Described chitosan quaternary ammonium salinity is 1.5mg/ml.
Embodiment 5
A kind of skin mucosa pasteurization towelette, comprise sterilizing non-woven fabrics, the disinfectant be carried on sterilizing non-woven fabrics, described disinfectant is prepared in the steps below: (1) takes chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, 4 parts, Cera Flava, povidone iodine 8 parts, glycyrrhizic acid dipotassium 4 parts, 4 parts, surfactant; 2 parts, carbamide, deionized water 40 parts are for subsequent use;
(2) nonylphenol polyoxyethylene ether sulfate taken in step (1) and surfactant, Cera Flava are added in container stir, then add in step (1) and take the stirring of chitosan quaternary ammonium salt, zephiran, povidone iodine, glycyrrhizic acid dipotassium and carbamide makes it dissolve completely, add the deionized water in step (1), regulate PH to be 7-9 and to get final product.
Described chitosan quaternary ammonium salt is N – N-propyl-N, N-dimethyl chitosan.
Embodiment 6
A kind of skin mucosa pasteurization towelette, comprise sterilizing non-woven fabrics, the disinfectant be carried on sterilizing non-woven fabrics, described disinfectant is prepared in the steps below: (1) takes chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, 4 parts, Cera Flava, povidone iodine 8 parts, glycyrrhizic acid dipotassium 4 parts, 4 parts, surfactant; 2 parts, carbamide, deionized water 40 parts are for subsequent use;
(2) nonylphenol polyoxyethylene ether sulfate taken in step (1) and surfactant, Cera Flava are added in container stir, then add in step (1) and take the stirring of chitosan quaternary ammonium salt, zephiran, povidone iodine, glycyrrhizic acid dipotassium and carbamide makes it dissolve completely, add the deionized water in step (1), regulate PH to be 7-9 and to get final product.
Described surfactant be CH3-(CH2)13N(CH3)2-O, octyl phenol polyoxyethylene, myristyl dimethyl amine oxide one or more.
Claims (7)
1. a skin mucosa pasteurization towelette, comprise sterilizing non-woven fabrics, the disinfectant be carried on sterilizing non-woven fabrics, described disinfectant is prepared in the steps below: (1) takes chitosan quaternary ammonium salt 8 parts, zephiran 4 parts, nonylphenol polyoxyethylene ether sulfate 8 parts, 4 parts, Cera Flava, povidone iodine 8 parts, glycyrrhizic acid dipotassium 4 parts, 4 parts, surfactant; 2 parts, carbamide, deionized water 40 parts are for subsequent use;
(2) nonylphenol polyoxyethylene ether sulfate taken in step (1) and surfactant, Cera Flava are added in container stir, then add in step (1) and take the stirring of chitosan quaternary ammonium salt, zephiran, povidone iodine, glycyrrhizic acid dipotassium and carbamide makes it dissolve completely, add the deionized water in step (1), regulate PH to be 7-9 and to get final product.
2. a kind of skin mucosa pasteurization towelette according to claim 1, is characterized in that: described skin mucosa pasteurization towelette sterilizing non-woven fabrics is placed in above-mentioned disinfectant to soak and obtain for 1-2 hour, keeps temperature to be 30-35 DEG C during immersion.
3. a kind of skin mucosa pasteurization towelette according to claim 1, is characterized in that: described step (2) operates at 30-35 DEG C.
4. a kind of skin mucosa pasteurization towelette according to claim 1, is characterized in that: described Cera Flava first melts before addition.
5. a kind of skin mucosa pasteurization towelette according to claim 1, is characterized in that: described chitosan quaternary ammonium salinity is 1.5mg/ml.
6. a kind of skin mucosa pasteurization towelette according to claim 1, is characterized in that: described chitosan quaternary ammonium salt is N – N-propyl-N, N-dimethyl chitosan.
7. a kind of skin mucosa pasteurization towelette according to claim 1, is characterized in that: described surfactant be CH3-(CH2)13N(CH3)2-O, octyl phenol polyoxyethylene, myristyl dimethyl amine oxide one or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410700142.9A CN104490633A (en) | 2014-11-28 | 2014-11-28 | Skin mucous membrane disinfection wet wipe |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410700142.9A CN104490633A (en) | 2014-11-28 | 2014-11-28 | Skin mucous membrane disinfection wet wipe |
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| Publication Number | Publication Date |
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| CN104490633A true CN104490633A (en) | 2015-04-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410700142.9A Pending CN104490633A (en) | 2014-11-28 | 2014-11-28 | Skin mucous membrane disinfection wet wipe |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496176A (en) * | 2016-06-14 | 2017-12-22 | 哈尔滨盈聚生物科技有限公司 | Safe and efficient antibacterial wet tissue and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060246120A1 (en) * | 2005-05-02 | 2006-11-02 | Kelly Albert R | Antiseptic wipes |
| CN102309280A (en) * | 2010-06-29 | 2012-01-11 | 大连欧派科技有限公司 | Towelette with rose smell |
| CN102488705A (en) * | 2011-12-08 | 2012-06-13 | 施耐克江苏生物制药有限公司 | Skin mucous membrane disinfectant for killing virus |
| CN102552060A (en) * | 2011-12-30 | 2012-07-11 | 华侨大学 | Quaternized chitosan containing wet wipe compound liquid with functions of anti-bacteria, moisture retention and skin protection and preparation method thereof |
-
2014
- 2014-11-28 CN CN201410700142.9A patent/CN104490633A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060246120A1 (en) * | 2005-05-02 | 2006-11-02 | Kelly Albert R | Antiseptic wipes |
| CN102309280A (en) * | 2010-06-29 | 2012-01-11 | 大连欧派科技有限公司 | Towelette with rose smell |
| CN102488705A (en) * | 2011-12-08 | 2012-06-13 | 施耐克江苏生物制药有限公司 | Skin mucous membrane disinfectant for killing virus |
| CN102552060A (en) * | 2011-12-30 | 2012-07-11 | 华侨大学 | Quaternized chitosan containing wet wipe compound liquid with functions of anti-bacteria, moisture retention and skin protection and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107496176A (en) * | 2016-06-14 | 2017-12-22 | 哈尔滨盈聚生物科技有限公司 | Safe and efficient antibacterial wet tissue and preparation method thereof |
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Application publication date: 20150408 |