CN104013573A - High-content liquid povidone-iodine - Google Patents
High-content liquid povidone-iodine Download PDFInfo
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- CN104013573A CN104013573A CN201410286042.6A CN201410286042A CN104013573A CN 104013573 A CN104013573 A CN 104013573A CN 201410286042 A CN201410286042 A CN 201410286042A CN 104013573 A CN104013573 A CN 104013573A
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Abstract
The invention relates to antisepsis and anti-inflammation medicaments, and particularly relates to high-content liquid povidone-iodine. The liquid povidone-iodine is prepared from the following raw materials in percentage by weight: 5.2-12.24 percent of iodine, 10-24 percent of polyvinylpyrrolidone, 2-4.8 percent of potassium iodide, 0.1-0.24 percent of potassium iodate, 15-36 percent of ethanol and the balance of water. The high-content liquid povidone-iodine is a reddish brown viscous liquid, is easily dissolved in water, has stable performance, strong sterilization efficacy and no irritation, is suitable for sterilization of operating parts and skin-mucosa or sterilization of aquatic water, can be used for preventing and treating bacteriosis of aquatic animals caused by vibrio, aeromonas hydrophila, edwardsiella tarda and the like and sterilizing the environment of livestock and poultry housings, plays a role in killing multiple bacteria, spores, viruses, fungi and the like, thus being a good iodine containing medical bactericide and epidemic prevention sanitizer.
Description
Technical field
The present invention relates to a kind of antibacterial-anti-inflammatory drug, specifically a kind of high amount of liquid povidone iodine.
Background technology
Povidone iodine (PVP-I), is a kind of containing iodine disinfectant, by discharging free-iodine, destroys thalline metabolism, makes antibacterial etc. microorganism deactivated, and antibacterial, virus and fungus are all had to good killing action.Be usually used in the sterilization of operative site, skin mucosa; Also can be used for the sterilization of breeding water body, the bacterial disease that control aquatic animal is caused by vibrio, Aeromonas hydrophila, tarda etc.; Also for poultry pouity dwelling place environment disinfected.
Povidone iodine in the market, available iodine content 9% ~ 12% be that yellowish-brown is to rufous amorphous powder, when actual use, generally all to be diluted to available iodine between 0.5% ~ 2%, and need to add second alcohol and water when the dilution of pulverous povidone iodine, also need to add sodium alkyl benzene sulfonate and citric acid (as the application for a patent for invention publication No. product that is CN102475678A) or add sodium hydrogen phosphate and citric acid (as the application for a patent for invention publication No. product that is CN102475679A), technique is more complicated, loaded down with trivial details all.
Domestic existing povidone iodine, available iodine content 5% ~ 12% can only be pulverulent solids, and in the povidone iodine of liquid, the effective content of iodine can only be below 5%, is generally 0.1%, 0.5%, 1%, 2% several specifications.Its technical reason is because in current povidone iodine, must ensure polyvinylpyrrolidone (PVP) and iodine (I
2) part by weight in about 9:1.In the time that polyvinylpyrrolidone (PVP) is less than this ratio, iodine just can not be stablized, and is easy to volatilization and reduction content in the time producing and preserve.And polyvinylpyrrolidone and iodine are all solids, so available iodine content reaches 10%(maximum 12%) time, just do not add the space of ethanol or water equal solvent.
Summary of the invention
In the povidone iodine of complex process when the present invention uses in order to solve the dilution of the Powdered povidone iodine of existing high-load, loaded down with trivial details and liquid, the lower problem of effective content of iodine, provides a kind of high amount of liquid povidone iodine.
The present invention is achieved by the following technical solutions: high amount of liquid povidone iodine is to be prepared from by the raw material of following percentage by weight,
Iodine 5.2% ~ 12.24%
Polyvinylpyrrolidone 10% ~ 24%
Potassium iodide 2% ~ 4.8%
Potassium iodate 0.1% ~ 0.24%
Ethanol 15% ~ 36%
Water surplus.
The content of its available iodine of high amount of liquid povidone iodine of the present invention is 5% ~ 12%.But the content of polyvinylpyrrolidone in the present invention (PVP) only has 10% ~ 24%, add second alcohol and water to abdicate space when preparing liquid, the potassium iodide of use 2% ~ 4.8% and 0.1% ~ 0.24% potassium iodate have replaced a large amount of polyvinylpyrrolidone (PVP), the same stability that can ensure high amount of liquid povidone iodine of the present invention, its stability is better with respect to original povidone iodine, be better than existing national standard, water solublity is more excellent simultaneously, and dilution only need add water while use.
In the present invention, potassium iodide and iodine form soluble complexes, and play hydrotropy effect, and make iodine stable, not volatile.And complex reaction is reversible, therefore still can keep the sterilizing power of iodine.And potassium iodate has certain stability to iodine, be a kind of strong oxidizer, make the reduzate iodine anion of free-iodine be oxidized to iodine, and keep disinfection vitality.
If the content of polyvinylpyrrolidone is less than 10% ~ 24%, the stability of iodine will be affected; If be greater than 24%, too thickness and cannot producing of povidone iodine.
If the content of potassium iodide is less than 2% ~ 4.8%, the stability of iodine will reduce; If be greater than 2% ~ 4.8%, can lose market value because increasing unnecessary cost.
If the content of potassium iodate is less than 0.1% ~ 0.24%, the stability of iodine will reduce; If be greater than 0.1% ~ 0.24%, will increase unnecessary cost.
When concrete use, adding water high amount of liquid povidone iodine is diluted to available iodine content is the solution between 0.1% ~ 2%, does not need other solvents, also without heating.Adopt the preparation method of high amount of liquid povidone iodine of the present invention, the high amount of liquid povidone iodine stability preparing is better, and water solublity is more excellent, uses more convenient.
The preparation method of described high amount of liquid povidone iodine,
The steps include:
(1) take 15% ~ 36% ethanol by gross weight;
(2) 2% ~ 4.8% potassium iodide of 5.2% ~ 12.24% iodine of gross weight and gross weight is put in ethanol, stirring and dissolving, obtains A liquid;
(3) take the water of surplus;
(4) 10% ~ 24% polyvinylpyrrolidone of gross weight is put into water, stirring and dissolving, obtains B liquid;
(5) A liquid is mixed with B liquid, and add 0.1% ~ 0.24% potassium iodate of gross weight, uniform stirring makes it to dissolve completely, obtains high amount of liquid povidone iodine.
High amount of liquid povidone iodine of the present invention, for rufous thick liquid, soluble in water, its stable performance, fungicidal effectiveness is strong, have no stimulation, be applicable to the sterilization of operative site, skin mucosa, also can be used for the sterilization of breeding water body, the bacterial disease that control aquatic animal is caused by vibrio, Aeromonas hydrophila, tarda etc., also, for poultry pouity dwelling place environment disinfected, various bacteria, spore, virus, fungus etc. being had to killing action, is a kind of well containing iodine medical bactericide and health and epidemic prevention disinfectant.And high amount of liquid povidone iodine stability of the present invention is better than existing national standard, water solublity is better than pulverous povidone iodine that content of iodine is identical.
experiment: the stability experiment of high amount of liquid povidone iodine
experiment 1: the high amount of liquid povidone iodine that available iodine content is 5%
High amount of liquid povidone iodine in this experiment, is to be prepared from by the raw material of following percentage by weight,
Iodine 5.2%
Polyvinylpyrrolidone 10%
Potassium iodide 2%
Potassium iodate 0.1%
Ethanol 15%
Water surplus.
High amount of liquid povidone iodine of the present invention (A) and the povidone iodine powder (B) of high-load are diluted to the product (solution that available iodine content is 1%) of same specification, carry out stability comparison, by the detection method of national standard be: respectively get solution 10ml, be placed in 50ml conical flask, shake up (in bottle, neck is sure not to stain), bottleneck covers one with the moistening filter paper of starch indicator solution, places.Standard is that 60 seconds are not aobvious blue.
Table 1 stability comparative result
experiment 2: the high amount of liquid povidone iodine that available iodine content is 10%
High amount of liquid povidone iodine in this experiment, is to be prepared from by the raw material of following percentage by weight,
Iodine 10.4%
Polyvinylpyrrolidone 20%
Potassium iodide 4%
Potassium iodate 0.2%
Ethanol 30%
Water surplus.
High amount of liquid povidone iodine of the present invention (A) and the povidone iodine powder (B) of high-load are diluted to the product (solution that available iodine content is 1%) of same specification, carry out stability comparison, by the detection method of national standard be: respectively get solution 10ml, be placed in 50ml conical flask, shake up (in bottle, neck is sure not to stain), bottleneck covers one with the moistening filter paper of starch indicator solution, places.Standard is that 60 seconds are not aobvious blue.
Table 2 stability comparative result
experiment 3: the high amount of liquid povidone iodine that available iodine content is 12%
High amount of liquid povidone iodine in this experiment, is to be prepared from by the raw material of following percentage by weight,
Iodine 12.24%
Polyvinylpyrrolidone 24%
Potassium iodide 4.8%
Potassium iodate 0.24%
Ethanol 36%
Water surplus.
High amount of liquid povidone iodine of the present invention (A) and the povidone iodine powder (B) of high-load are diluted to the product (solution that available iodine content is 1%) of same specification, carry out stability comparison, by the detection method of national standard be: respectively get solution 10ml, be placed in 50ml conical flask, shake up (in bottle, neck is sure not to stain), bottleneck covers one with the moistening filter paper of starch indicator solution, places.Standard is that 60 seconds are not aobvious blue.
Table 3 stability comparative result
| Product | Stability | Evaluate |
| The product of making after A dilution | 185 seconds not aobvious blue | Excellent |
| The product of making after B dilution | 65 seconds not aobvious blue | Qualified |
Detailed description of the invention
embodiment 1
The preparation method of described high amount of liquid povidone iodine,
The steps include:
(1) take 15% ethanol by gross weight;
(2) 2% potassium iodide of 5.2% iodine of gross weight and gross weight is put in ethanol, stirring and dissolving, obtains A liquid;
(3) take 67.7% water of gross weight;
(4) 10% polyvinylpyrrolidone of gross weight is put into water, stirring and dissolving, obtains B liquid;
(5) A liquid is mixed with B liquid, and add 0.1% potassium iodate of gross weight, uniform stirring makes it to dissolve completely, obtains high amount of liquid povidone iodine.
embodiment 2
The preparation method of described high amount of liquid povidone iodine,
The steps include:
(1) take 30% ethanol by gross weight;
(2) 4% potassium iodide of 10.4% iodine of gross weight and gross weight is put in ethanol, stirring and dissolving, obtains A liquid;
(3) take 35.4% water of gross weight;
(4) 20% polyvinylpyrrolidone of gross weight is put into water, stirring and dissolving, obtains B liquid;
(5) A liquid is mixed with B liquid, and add 0.2% potassium iodate of gross weight, uniform stirring makes it to dissolve completely, obtains high amount of liquid povidone iodine.
embodiment 3
The preparation method of described high amount of liquid povidone iodine,
The steps include:
(1) take 36% ethanol by gross weight;
(2) 4.8% potassium iodide of 12.24% iodine of gross weight and gross weight is put in ethanol, stirring and dissolving, obtains A liquid;
(3) take 22.72% water of gross weight;
(4) 24% polyvinylpyrrolidone of gross weight is put into water, stirring and dissolving, obtains B liquid;
(5) A liquid is mixed with B liquid, and add 0.24% potassium iodate of gross weight, uniform stirring makes it to dissolve completely, obtains high amount of liquid povidone iodine.
embodiment 4
The preparation method of described high amount of liquid povidone iodine,
The steps include:
(1) take 18% ethanol by gross weight;
(2) 2% potassium iodide of 5.2% iodine of gross weight and gross weight is put in ethanol, stirring and dissolving, obtains A liquid;
(3) take 62.7% water of gross weight;
(4) 12% polyvinylpyrrolidone of gross weight is put into water, stirring and dissolving, obtains B liquid;
(5) A liquid is mixed with B liquid, and add 0.1% potassium iodate of gross weight, uniform stirring makes it to dissolve completely, obtains high amount of liquid povidone iodine.
Claims (2)
1. high amount of liquid povidone iodine, is characterized in that, be to be prepared from by the raw material of following percentage by weight,
Iodine 5.2% ~ 12.24%
Polyvinylpyrrolidone 10% ~ 24%
Potassium iodide 2% ~ 4.8%
Potassium iodate 0.1% ~ 0.24%
Ethanol 15% ~ 36%
Water surplus.
2. the preparation method of high amount of liquid povidone iodine claimed in claim 1, is characterized in that,
The steps include:
(1) take 15% ~ 36% ethanol by gross weight;
(2) 2% ~ 4.8% potassium iodide of 5.2% ~ 12.24% iodine of gross weight and gross weight is put in ethanol, stirring and dissolving, obtains A liquid;
(3) take the water of surplus;
(4) 10% ~ 24% polyvinylpyrrolidone of gross weight is put into water, stirring and dissolving, obtains B liquid;
(5) A liquid is mixed with B liquid, and add 0.1% ~ 0.24% potassium iodate of gross weight, uniform stirring makes it to dissolve completely, obtains high amount of liquid povidone iodine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410286042.6A CN104013573B (en) | 2014-06-25 | 2014-06-25 | Available iodine content is the liquid PVP-I of 5-12% |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410286042.6A CN104013573B (en) | 2014-06-25 | 2014-06-25 | Available iodine content is the liquid PVP-I of 5-12% |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104013573A true CN104013573A (en) | 2014-09-03 |
| CN104013573B CN104013573B (en) | 2016-08-24 |
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| CN201410286042.6A Active CN104013573B (en) | 2014-06-25 | 2014-06-25 | Available iodine content is the liquid PVP-I of 5-12% |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224825A (en) * | 2014-09-16 | 2014-12-24 | 王子章 | Disinfectant and preparation method thereof |
| CN105853397A (en) * | 2016-04-26 | 2016-08-17 | 上海宇昂新材料科技有限公司 | Povidone iodine concentrated solution as well as preparation method and application thereof |
| CN106386853A (en) * | 2016-08-30 | 2017-02-15 | 四川创美克科技有限公司 | Multi-effect active iodine disinfectant as well as preparation method and application thereof |
| CN108403671A (en) * | 2018-06-11 | 2018-08-17 | 佛山市南海东方澳龙制药有限公司 | Betagen Solution and preparation method thereof |
| CN109362797A (en) * | 2018-12-04 | 2019-02-22 | 怀化学院 | Iodic disinfecting liquid and preparation method thereof |
| CN110037940A (en) * | 2019-05-22 | 2019-07-23 | 浙江欧洁科技股份有限公司 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
| CN111657297A (en) * | 2020-07-10 | 2020-09-15 | 四川成邦药业有限公司 | Chelated povidone iodine solution and preparation method thereof |
| CN112841181A (en) * | 2020-12-31 | 2021-05-28 | 佛山市正典生物技术有限公司 | Stable iodine-containing disinfectant and preparation method thereof |
| CN113288913A (en) * | 2021-05-25 | 2021-08-24 | 厦门惠盈动物药业有限公司 | Povidone iodine solution and preparation method thereof |
| CN113768951A (en) * | 2021-08-25 | 2021-12-10 | 广东瑞吉生物技术有限公司 | High-polyiodide preparation and preparation method and application thereof |
| CN114672182A (en) * | 2020-12-24 | 2022-06-28 | 苏州北辰新材料科技有限公司 | Coating composition, preparation method thereof and coating |
| CN114931586A (en) * | 2021-06-25 | 2022-08-23 | 浙江科瑞特生物科技有限公司 | Povidone-iodine solution for animal oral administration and preparation method thereof |
| CN115337410A (en) * | 2022-08-30 | 2022-11-15 | 四川大学华西医院 | Tissue staining agent for endoscopic screening of canceration and preparation method thereof |
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| CN102949338A (en) * | 2012-11-17 | 2013-03-06 | 河南省康星药业有限公司 | 5% povidone-iodine solution for dairy cattle with strong stability and preparation process thereof |
| CN102973601A (en) * | 2012-12-26 | 2013-03-20 | 哈尔滨五牛生物技术开发有限公司 | Medicated bath film forming agent for preventing bouine mastitis and preparation method of medicated bath film forming agent |
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2014
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Patent Citations (2)
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| CN102949338A (en) * | 2012-11-17 | 2013-03-06 | 河南省康星药业有限公司 | 5% povidone-iodine solution for dairy cattle with strong stability and preparation process thereof |
| CN102973601A (en) * | 2012-12-26 | 2013-03-20 | 哈尔滨五牛生物技术开发有限公司 | Medicated bath film forming agent for preventing bouine mastitis and preparation method of medicated bath film forming agent |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224825A (en) * | 2014-09-16 | 2014-12-24 | 王子章 | Disinfectant and preparation method thereof |
| CN105853397A (en) * | 2016-04-26 | 2016-08-17 | 上海宇昂新材料科技有限公司 | Povidone iodine concentrated solution as well as preparation method and application thereof |
| CN105853397B (en) * | 2016-04-26 | 2019-03-05 | 上海宇昂新材料科技有限公司 | A kind of povidone iodine concentrate and its preparation method and application |
| CN106386853A (en) * | 2016-08-30 | 2017-02-15 | 四川创美克科技有限公司 | Multi-effect active iodine disinfectant as well as preparation method and application thereof |
| CN108403671B (en) * | 2018-06-11 | 2021-04-27 | 佛山市南海东方澳龙制药有限公司 | Povidone-iodine solution and preparation method thereof |
| CN108403671A (en) * | 2018-06-11 | 2018-08-17 | 佛山市南海东方澳龙制药有限公司 | Betagen Solution and preparation method thereof |
| CN109362797A (en) * | 2018-12-04 | 2019-02-22 | 怀化学院 | Iodic disinfecting liquid and preparation method thereof |
| CN110037940A (en) * | 2019-05-22 | 2019-07-23 | 浙江欧洁科技股份有限公司 | A kind of sterilizing oral disinfection mouthwash and preparation method thereof and application method |
| CN111657297A (en) * | 2020-07-10 | 2020-09-15 | 四川成邦药业有限公司 | Chelated povidone iodine solution and preparation method thereof |
| CN114672182A (en) * | 2020-12-24 | 2022-06-28 | 苏州北辰新材料科技有限公司 | Coating composition, preparation method thereof and coating |
| CN112841181A (en) * | 2020-12-31 | 2021-05-28 | 佛山市正典生物技术有限公司 | Stable iodine-containing disinfectant and preparation method thereof |
| CN112841181B (en) * | 2020-12-31 | 2022-06-17 | 佛山市正典生物技术有限公司 | Stable iodine-containing disinfectant and preparation method thereof |
| CN113288913A (en) * | 2021-05-25 | 2021-08-24 | 厦门惠盈动物药业有限公司 | Povidone iodine solution and preparation method thereof |
| CN114931586A (en) * | 2021-06-25 | 2022-08-23 | 浙江科瑞特生物科技有限公司 | Povidone-iodine solution for animal oral administration and preparation method thereof |
| CN114931586B (en) * | 2021-06-25 | 2023-09-29 | 浙江科瑞特生物科技有限公司 | Povidone-iodine solution for animal oral administration and preparation method thereof |
| CN113768951A (en) * | 2021-08-25 | 2021-12-10 | 广东瑞吉生物技术有限公司 | High-polyiodide preparation and preparation method and application thereof |
| CN115337410A (en) * | 2022-08-30 | 2022-11-15 | 四川大学华西医院 | Tissue staining agent for endoscopic screening of canceration and preparation method thereof |
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