CN106265729A - A kind of disinfectant tamed iodine - Google Patents
A kind of disinfectant tamed iodine Download PDFInfo
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- CN106265729A CN106265729A CN201610886257.0A CN201610886257A CN106265729A CN 106265729 A CN106265729 A CN 106265729A CN 201610886257 A CN201610886257 A CN 201610886257A CN 106265729 A CN106265729 A CN 106265729A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
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- Pharmacology & Pharmacy (AREA)
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Abstract
A kind of disinfectant tamed iodine of the present invention, available iodine concentration of the present invention is the solution of 250mg/L, and to staphylococcus aureus, Pseudomonas aeruginosa, the logarithm value of averagely killing of effect 2min is all higher than 5.00；Available iodine concentration is the solution of 500mg/L, and effect 2min is more than 5.00 to the logarithm value of averagely killing of Candida albicans；There is bactericidal action；Available iodine concentration is 500mg/L 2min action time, and skin surface natural bacteria is had killing action；The present invention has stronger killing action to staphylococcus aureus, pseudomonas aeruginosa, Candida albicans, and to skin, damaged skin, animal eyes nonirritant, bactericidal action is fast, extremely strong to percutaneous permeability, sterilization is persistently, easy to use, being not necessary to de-iodine, character is stable.
Description
Technical field
The present invention relates to a kind of disinfectant solution, be specifically related to a kind of disinfectant tamed iodine, belong to medical treatment sterilization field.
Background technology
Povidone iodine is the ambiguity complex that iodine is formed with surfactant, and surfactant is carrier and the solubilizing agent of iodine,
I presented in complexation or inclusion in carrier.In water, iodine is free lentamente out produces bactericidal action.
Since latter half in 19th century, many people have spoken highly of the iodine usefulness as antibacterial, and 1814 by Gay-
The nonmetalloid iodine that lussac is named, is that French scientist Courtors1812 is found.Nature does not dissociate
The iodine of state, other compounds mostly being iodide or iodine of discovery.The latter in varec, oil well saline and Chile nitric acid iodine
In exist in a large number.First the specific reference material using iodine in wound is to deliver nineteen thirty-nine.The U.S. is in the Civil War phase
Between, battlefield employs iodine.Within 1830, American Pharmacopeia have recognised tincture and the liniment of iodine.Iodine class (compound iodine) disinfectant is a class
External conventional disinfectant, has the features such as spectrum curative effect, low toxicity.1964 by American National aviation NASA be specifically designed to Ah
The sterilization of the spacelab of POLO space program, thus obtain achievement greatly and achieve instant fame.Present stage has been widely used for
Surgical hand, skin, mucosa adjust sterilization etc..In recent years, the application of domestic compound iodine is gradually wide, for different sterilisation purposes, can drink
Feelings select the iodine class disinfectant solution that iodine tincture and povidone iodine etc. are different.
Povidone iodine has liquid and solid two kinds, and povidone iodine can also make the dosage forms such as suppository, unguentum, Emulsion to adapt to difference in addition
Requirement.Liquid povidone iodine is brown, is smooth to the touch, and available iodine mass concentration is typically between 5-10g.The usual available iodine of Vidine
Mass fraction be 10%-20%, mostly be brown ceramic powder, after being dissolved in water, liquid is brown, and with iodine liquid phase ratio, povidone iodine is non-stimulated
Property abnormal smells from the patient, the surface of object catches color and easily washes away, and liquid povidone iodine and Vidine character are more stable.The preparation side of liquid povidone iodine
Method is: I adds surfactant hydrotropy, becomes iodine solution, generation complex of heating.But can serve as povidone iodine carrier
Compound a lot, various surfactants, some Molecularly Imprinted Polymers, starch hydrolysate etc., the povidone iodine kind therefore formed
Class is the most a lot.But povidone iodine mainly has following classification using surfactant as carrier: the most poly-second of (1) non-ionic surface active iodine
Alkene pyrrolidone iodine (PVP-I), NPE iodine (POP-I) polyglycol iodine (PEG-I) I-PVA (PVP-
I) wherein povidon iodine (PVP-I) loaded China pharmacopeia such as polyalcohol ether iodine (NP-I), most of povidone iodine preparations carry
Body is usually nonionic surfactant, and this type of povidone iodine character is uncertain, but uses less, and anion surface active iodine, such as alkyl
Iodine salt chelated iodine, this type of poor stability, but decontamination is good, and the bactericidal mechanism of povidone iodine is generally believed to be based on its iodination
And the destruction to cellulosa, free-iodine can be directly and tropina bacterial enzyme albumen generation halogenation broken
The biologic activity of bad protein causes microorganism dead.Due to surface activity and the emulsification of povidone iodine, on the one hand povidone iodine penetrates
Property very strong, on the other hand emulsification makes cell wall damage, and iodine enters intracellular in a large number.There are some researches show that povidone iodine destroys cell
The permeability barrier of film, causes cellular content to leak outside, and causes microorganism dead, therefore hundred million source TM povidone iodine prepared by my company
Disinfectant solution, having selected I and NPE is that surface activity carrier is combined collocation, is according to above phase
Closing character to prepare, this product proves by test: to staphylococcus aureus, Candida albicans, Aerugo vacation is unicellular has relatively
Strong killing action.
Summary of the invention
For the problems referred to above, the present invention provides a kind of disinfectant tamed iodine, and its step is simple and convenient to operate, safety high.
The technical scheme that the present invention takes is:
A kind of disinfectant tamed iodine, this formula calculates with preparation 1000kg0.5% disinfectant tamed iodine, iodine 5.5kg, and nonyl phenol gathers
Oxygen vinyl Ether 55kg, deionized water 939.5kg, 0.5% disinfectant tamed iodine 1000kg, wherein: iodine (medical grade) content 99.8%,
NPE (technical grade) content 99.5%；Technological process: 1, weigh the raw material iodine 5.5kg that content is 99.8%；
2, NPE 55kg is weighed；3, put into utensil reactor after mixing heat and stir 120-150 minute；4, make
Fully dissolve the complex 60.5kg forming iodine with NPE；5, deionized water 939.5kg is weighed；6, by iodine
With NPE mixed liquor and deionized water mix and blend 60 minutes, and stand；7, assay, if meet enterprise
Industry standard；8, fill is carried out after the assay was approved；9, bottleneck is sealed up, labelled, use dedicated paper case packing；9, pack complete, enter
Storehouse.
Brown liquid of the present invention, has weak iodine taste, is dissolved in water, in faintly acid, and formula constituent:
| Material name | Specification | Throwing amount (kg) |
| Iodine (99.8%) | Pharmaceutical grade | 5.5 |
| NPE | Technical grade | 5.5 |
| Deionized water | 939.5 |
Available iodine concentration of the present invention is the solution of 250mg/L, to staphylococcus aureus, Pseudomonas aeruginosa, effect
The logarithm value of averagely killing of 2min is all higher than 5.00；Available iodine concentration is the solution of 500mg/L, and 2min is to Candida albicans in effect
Averagely kill logarithm value more than 5.00；There is bactericidal action；Available iodine concentration is 500mg/L 2min action time, to skin
Surface natural bacteria have killing action.
Toxicology of the present invention is checked: acute oral toxicity test, after this disinfectant solution stock solution is to nickname kind mouse stomach, has no
Substantially poisoning symptom, two weeks thickness cut open and kill whole surviving animals, and internal organs no abnormality seen changes, therefore acute to Kunming mouse of judgement
LD50 of passing through mouth is more than 5000mg/kg.bw, true border non-toxic type.
Micronuclei In The Mouse Bone Marrow of the present invention is tested, this disinfectant solution to PCEMNR without causing chromosome damage
Effect.
Irritation test of the present invention, this disinfectant solution is to rabbit no skin irritation, and this disinfectant solution is non-stimulated to rabbit eyes
Property, this disinfectant solution is to rabbit vagina nonirritant.
Product development process of the present invention, weighs the iodine 5.5kg that content is 99.8%, then weighs NPE
40kg is allowed to mix and blend and dissolves, and is configured to iodine solution, heats and generates the complex of iodine, weighs 939.5kg and take ionized water, with iodine
Solution mix and blend, is allowed to fully dissolve be configured to disinfectant tamed iodine, after testing, qualified after be filled into bottle.
Beneficial effect acquired by the present invention:
The present invention has stronger killing action, to skin to staphylococcus aureus, pseudomonas aeruginosa, Candida albicans
Skin, damaged skin, animal eyes nonirritant, bactericidal action is fast, extremely strong to percutaneous permeability, and sterilization is persistently, easy to use, no
Must take off iodine, character is stable.
The ultimate principle of the present invention and principal character and advantages of the present invention have more than been shown and described.The technology of the industry
Personnel, it should be appreciated that the present invention is not restricted to the described embodiments, simply illustrating this described in above-described embodiment and description
The principle of invention, without departing from the spirit and scope of the present invention, the present invention also has various changes and modifications, and these become
Change and improvement both falls within scope of the claimed invention.Claimed scope by appending claims and
Equivalent defines.
Accompanying drawing explanation
Fig. 1 is the flowage structure figure of the present invention.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, the illustrative examples invented at this and explanation
It is used for explaining the present invention, but not as a limitation of the invention.
As it is shown in figure 1, a kind of disinfectant tamed iodine, this formula calculates with preparation 1000kg0.5% disinfectant tamed iodine, iodine
5.5kg, NPE 55kg, deionized water 939.5kg, 0.5% disinfectant tamed iodine 1000kg, wherein: iodine is (medical
Level) content 99.8%, NPE (technical grade) content 99.5%；Technological process: 1, weighing content is 99.8%
Raw material iodine 5.5kg；2, NPE 55kg is weighed；3, put into utensil reactor after mixing heat and stir
120-150 minute；4, it is allowed to fully dissolve the complex 60.5kg forming iodine with NPE；5, deionization is weighed
Water 939.5kg；6, by iodine and NPE mixed liquor and deionized water mix and blend 60 minutes, and stand；7, contain
It is fixed to measure, if meet company standard；8, fill is carried out after the assay was approved；9, bottleneck is sealed up, labelled, use dedicated paper case and bag
Dress；9, pack complete, warehouse-in.
Brown liquid of the present invention, has weak iodine taste, is dissolved in water, in faintly acid, and formula constituent:
| Material name | Specification | Throwing amount (kg) |
| Iodine (99.8%) | Pharmaceutical grade | 5.5 |
| NPE | Technical grade | 5.5 |
| Deionized water | 939.5 |
Available iodine concentration of the present invention is the solution of 250mg/L, to staphylococcus aureus, Pseudomonas aeruginosa, effect
The logarithm value of averagely killing of 2min is all higher than 5.00；Available iodine concentration is the solution of 500mg/L, and 2min is to Candida albicans in effect
Averagely kill logarithm value more than 5.00；There is bactericidal action；Available iodine concentration is 500mg/L 2min action time, to skin
Surface natural bacteria have killing action.
Toxicology of the present invention is checked: acute oral toxicity test, after this disinfectant solution stock solution is to nickname kind mouse stomach, has no
Substantially poisoning symptom, two weeks thickness cut open and kill whole surviving animals, and internal organs no abnormality seen changes, therefore acute to Kunming mouse of judgement
LD50 of passing through mouth is more than 5000mg/kg.bw, true border non-toxic type；Micronuclei In The Mouse Bone Marrow of the present invention is tested, and this disinfectant solution is to Mouse Bone
Marrow polychromatic erythrocyte is without causing the effect of chromosome damage；Irritation test of the present invention, this disinfectant solution is non-stimulated to rabbit skin
Property, this disinfectant solution is to rabbit eye irritation, and this disinfectant solution is to rabbit vagina nonirritant；Product development process of the present invention,
Weigh the iodine 5.5kg that content is 99.8%, then weigh NPE 40kg and be allowed to mix and blend and dissolve, be configured to iodine
Solution, heats and generates the complex of iodine, weigh 939.5kg and take ionized water, with iodine solution mix and blend, be allowed to fully dissolve configuration
Become disinfectant tamed iodine, after testing, qualified after be filled into bottle.
Beneficial effect acquired by the present invention: the present invention is to staphylococcus aureus, pseudomonas aeruginosa, Candida albicans
Bacterium has stronger killing action, and to skin, damaged skin, animal eyes nonirritant, bactericidal action is fast, to percutaneous permeability pole
By force, sterilization is persistently, easy to use, is not necessary to de-iodine, and character is stable.
Claims (5)
1. a disinfectant tamed iodine, is characterized in that: this formula calculates with preparation 1000kg0.5% disinfectant tamed iodine, iodine 5.5kg,
NPE 55kg, deionized water 939.5kg, 0.5% disinfectant tamed iodine 1000kg, wherein: iodine (medical grade) contains
Amount 99.8%, NPE (technical grade) content 99.5%；Technological process: 1, weigh the raw material that content is 99.8%
Iodine 5.5kg；2, NPE 55kg is weighed；3, put into utensil reactor after mixing heat and stir 120-150
Minute；4, it is allowed to fully dissolve the complex 60.5kg forming iodine with NPE；5, deionized water is weighed
939.5kg；6, by iodine and NPE mixed liquor and deionized water mix and blend 60 minutes, and stand；7, content
Measure, if meet company standard；8, fill is carried out after the assay was approved；9, bottleneck is sealed up, labelled, use dedicated paper case and bag
Dress；9, pack complete, warehouse-in；Brown liquid of the present invention, has weak iodine taste, is dissolved in water, in faintly acid, and formula constituent:
Available iodine concentration of the present invention is the solution of 250mg/L, to staphylococcus aureus, Pseudomonas aeruginosa, effect 2min's
Averagely kill logarithm value and be all higher than 5.00；Available iodine concentration is the solution of 500mg/L, effect average to Candida albicans of 2min
Kill logarithm value more than 5.00；There is bactericidal action；Available iodine concentration is 500mg/L 2min action time, to skin surface certainly
So bacterium has killing action.
2. a kind of disinfectant tamed iodine as claimed in claim 1, it is characterised in that: toxicology of the present invention is checked: acute oral poison
Property test, after this disinfectant solution stock solution is to nickname kind mouse stomach, have no obvious poisoning symptom, two weeks thickness are cutd open and being killed all survivals and move
Thing, internal organs no abnormality seen changes, therefore judges the acute oral LD50 of Kunming mouse more than 5000mg/kg.bw, true border without
Poison class.
3. a kind of disinfectant tamed iodine as claimed in claim 1, it is characterised in that: Micronuclei In The Mouse Bone Marrow of the present invention is tested, and this disappears
Venom to PCEMNR without cause chromosome damage effect.
4. a kind of disinfectant tamed iodine as claimed in claim 1, it is characterised in that: irritation test of the present invention, this disinfectant solution pair
Rabbit no skin irritation, this disinfectant solution is to rabbit eye irritation, and this disinfectant solution is to rabbit vagina nonirritant.
5. a kind of disinfectant tamed iodine as claimed in claim 1, it is characterised in that: product development process of the present invention, weigh content
Be the iodine 5.5kg of 99.8%, then weigh NPE 40kg be allowed to mix and blend dissolve, be configured to iodine solution, add
Temperature generates the complex of iodine, weighs 939.5kg and takes ionized water, with iodine solution mix and blend, is allowed to fully dissolve be configured to povidone iodine
Disinfectant solution, after testing, qualified after be filled into bottle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610886257.0A CN106265729A (en) | 2016-10-11 | 2016-10-11 | A kind of disinfectant tamed iodine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610886257.0A CN106265729A (en) | 2016-10-11 | 2016-10-11 | A kind of disinfectant tamed iodine |
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| Publication Number | Publication Date |
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| CN106265729A true CN106265729A (en) | 2017-01-04 |
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| CN201610886257.0A Pending CN106265729A (en) | 2016-10-11 | 2016-10-11 | A kind of disinfectant tamed iodine |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468706A (en) * | 2017-09-30 | 2017-12-15 | 蚌埠科卫消毒药剂有限公司 | A kind of disinfectant tamed iodine and preparation method thereof |
| CN107595881A (en) * | 2017-09-30 | 2018-01-19 | 蚌埠科卫消毒药剂有限公司 | A kind of skin mucosa disinfectant and preparation method thereof |
| CN111904976A (en) * | 2020-04-17 | 2020-11-10 | 姚志勇 | Method for killing microorganism in vivo with iodine-containing preparation |
| CN113244262A (en) * | 2020-02-07 | 2021-08-13 | 北京天衡军威医药技术开发有限公司 | Inhalation powder spray preparation for preventing and treating respiratory infectious diseases |
| CN113244263A (en) * | 2020-02-07 | 2021-08-13 | 北京天衡军威医药技术开发有限公司 | Aerosol inhalation preparation for preventing and treating respiratory infectious diseases |
| US20210259253A1 (en) * | 2020-02-26 | 2021-08-26 | Carefusion Corporation | Systems and methods for sterilizing iodophor compositions |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785477A (en) * | 2009-01-23 | 2010-07-28 | 上海利康消毒高科技有限公司 | Polyoxyethylene nonyl phenyl ether iodine complex disinfecting solution and preparation method thereof |
-
2016
- 2016-10-11 CN CN201610886257.0A patent/CN106265729A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785477A (en) * | 2009-01-23 | 2010-07-28 | 上海利康消毒高科技有限公司 | Polyoxyethylene nonyl phenyl ether iodine complex disinfecting solution and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468706A (en) * | 2017-09-30 | 2017-12-15 | 蚌埠科卫消毒药剂有限公司 | A kind of disinfectant tamed iodine and preparation method thereof |
| CN107595881A (en) * | 2017-09-30 | 2018-01-19 | 蚌埠科卫消毒药剂有限公司 | A kind of skin mucosa disinfectant and preparation method thereof |
| CN113244262A (en) * | 2020-02-07 | 2021-08-13 | 北京天衡军威医药技术开发有限公司 | Inhalation powder spray preparation for preventing and treating respiratory infectious diseases |
| CN113244263A (en) * | 2020-02-07 | 2021-08-13 | 北京天衡军威医药技术开发有限公司 | Aerosol inhalation preparation for preventing and treating respiratory infectious diseases |
| US20210259253A1 (en) * | 2020-02-26 | 2021-08-26 | Carefusion Corporation | Systems and methods for sterilizing iodophor compositions |
| CN111904976A (en) * | 2020-04-17 | 2020-11-10 | 姚志勇 | Method for killing microorganism in vivo with iodine-containing preparation |
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Application publication date: 20170104 |