CN102349541A - New application of iodine cyclodextrin inclusion compound - Google Patents
New application of iodine cyclodextrin inclusion compound Download PDFInfo
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- CN102349541A CN102349541A CN2011102281364A CN201110228136A CN102349541A CN 102349541 A CN102349541 A CN 102349541A CN 2011102281364 A CN2011102281364 A CN 2011102281364A CN 201110228136 A CN201110228136 A CN 201110228136A CN 102349541 A CN102349541 A CN 102349541A
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Abstract
The invention discloses a new application of an iodine cyclodextrin inclusion compound and particularly discloses an application of Cydiodine in preparing a medicament for disinfecting. According to the invention, the cydiodine can be used for effectively disinfecting the drinking water, medical appliances, tableware and bedding, vegetables and fruits, surfaces of organisms, environment, fishponds or swimming pools.
Description
Technical field
The invention belongs to the sterile products field, relate to the new purposes of iodine cyclodextrin inclusion compound, and the composition that provides based on this new purposes.
Background technology
At present the disinfectant kind used in the hygiene medical treatment industry of China is a lot, but these disinfectants exist that Disinfection Effect is undesirable, the scope of application is single, excitant is big, complex manufacturing and to the unusual shortcoming such as strictness and limited their extensive use of working condition requirement.Wherein drinking water disinfect almost completely is a chlorhexidine-containing disinfectant.Organic matter combines to generate harmful substances such as chloroform in chlorine and the water, is referred to as total alkyl halide.The alkyl halide compounds has strong renal toxicity and neurotoxicity, and extremely strong carcinogenesis is arranged.For preventing its toxic and side effect, although in drinking water standard, haloform (THM) content has been done clear and definite restriction, because water quality is polluted day by day, employed chlorine dose is compelled to be increased, and haloform is difficult to control, and its potential hazard is difficult to eliminate.
Iodine is used for the history in existing more than 150 year of body sterilization.Iodine class disinfectant is pathogene such as a type of quick, efficient, broad-spectrum disinfectant, its ability kill bacteria, brood cell, virus, phage, mycobacterium, protozoon, fungi.Because iodine solvability in water is little, only be 1.315 * 10 under 25 ℃
-3Mol/L; Room temperature is prone to distillation, and content is unstable; To mucocutaneous drawbacks limit such as excitant have been arranged its extensive use.Research to iodine has in recent years obtained new breakthrough; Novel Operand is further developed; Existence from iodine divides at present; Mainly contain types such as iodine, Iodophor, organic iodine, iodine resin, amino acid iodine; Wherein obtained using the most widely with the complex compound of polyvinylpyrrolidone (PVP) with iodine; Particularly they use very extensive when perhaps the article of inorganic matter carry out disinfection outside organism; For example be used for drinking water disinfection, medical apparatus sterilizing, the sterilization of tableware bedding, vegetable and fruit sterilization, environment disinfected, even can be used as wound disinfection.Yet PVP is a kind of high molecular surfactant, and mean molecule quantity 10000-70000 than difficult for biological degradation, uses its residual accumulating can cause environmental pollution for a long time; What play sterilization in the chelated iodine preparation only is the free state iodine molecule that from the PVP micelle, slowly releases.
Therefore, for drinking water, medicine equipment, tableware bedding, vegetable and fruit, environment, organism surface provide a kind of effectively, the sterilization method of safety, environmental protection is the urgent expectations of those skilled in the art.
Summary of the invention
The objective of the invention is to for drinking water, medicine equipment, tableware bedding, vegetable and fruit, environment, organism surface provide a kind of effectively, the sterilization method of safety, environmental protection.The inventor is surprisingly found out that, uses iodine cyclodextrin inclusion compound (also can be described as ground, west iodine in this article) as the disinfectant of organism surface sterilization, to have very effective bactericidal effect, and be easy to post processing through the article of sterilization processing.The present invention is based on above-mentioned discovery and be accomplished.
For this reason, first aspect present invention provides the purposes of the medicament that western ground iodine is used for sterilizing in preparation.
According to the purposes of first aspect present invention, wherein said sterilization is selected from: drinking water disinfection, medical apparatus sterilizing, the sterilization of tableware bedding, vegetable and fruit sterilization, organism surface sterilization, environment disinfected, fishpond sterilization, swimming pool sterilization.
Purposes according to first aspect present invention; Wherein said sterilization is that said medicament drops in the corresponding water and carries out disinfection, and is 1～1000mg/L in its concentration in water of available iodine (I) wherein, preferred 10～500mg/L; Preferred 10～250mg/L, preferred 10～200mg/L.
According to the purposes of first aspect present invention, wherein said drinking water disinfection is said medicament directly to be put in the drinking water carry out disinfection.
Purposes according to first aspect present invention; Wherein said medical apparatus sterilizing, the sterilization of tableware bedding, vegetable and fruit sterilization and organism surface sterilization are that said medicament is dropped in the water (for example distilled water, redistilled water, deionized water or other medicinal water); Make this medicament dissolving or dispersion, be used for then medicine equipment, tableware bedding, vegetable and fruit or organism are carried out disinfection.
According to the purposes of first aspect present invention, the sterilization of wherein said fishpond, swimming pool sterilization are to make said fish or swimmer leave fishpond or swimming pool, fishpond or swimming pool are carried out disinfection again.
According to the purposes of first aspect present invention, wherein said medicament randomly is used with neutralizer.Said neutralizer is after carrying out disinfection with medicament according to the invention, extraordinarily go into 0.8～1.5 of available iodine (I) mole, preferably extraordinarily goes into 0.9～1.2, preferably extraordinarily goes into 1.0～1.2.In one embodiment, said neutralizer is selected from vitamin C, sodium thiosulfate and comprises their composition.
Second aspect present invention provides a kind of sterilization method, and it carries out disinfection to drinking water, medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment, fishpond or swimming pool, and this method may further comprise the steps:
(i) west is provided iodine or the composition of iodine with comprising the west;
(ii) supply drinking water, medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment, fishpond, swimming pool;
(iii) randomly, during to medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment disinfected, the water of sterilization usefulness is provided;
The iodine or the composition of iodine with (iv) in the (ii) said drinking water of step, fishpond water, swimming pool water or the (iii) said water of step, adding the said west of step (i) with comprising the west; To said drinking water, fishpond water or the disinfection of swimming pool water, perhaps use the (iii) said water of step that is added with ground, west iodine to said medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment disinfection;
(v) add neutralizer in the drinking water after sterile-processed, fishpond water or the swimming pool water, perhaps optional uses neutralizer to the medicine equipment after sterile-processed, tableware bedding, vegetable and fruit, organism surface, environment.
According to the method for second aspect present invention, wherein said west ground iodine or the composition that comprises ground, west iodine add in the entry, are 1～1000mg/L in its concentration in water of available iodine (I), preferred 10～500mg/L, preferred 10～250mg/L, preferred 10～200mg/L.
According to the method for second aspect present invention, wherein said drinking water disinfection is said medicament directly to be put in the drinking water carry out disinfection.
Method according to second aspect present invention; Wherein said medical apparatus sterilizing, the sterilization of tableware bedding, vegetable and fruit sterilization and organism surface sterilization are that said medicament is dropped in the water (for example distilled water, redistilled water, deionized water or other medicinal water); Make this medicament dissolving or dispersion, be used for then medicine equipment, tableware bedding, vegetable and fruit or organism are carried out disinfection.
According to the method for second aspect present invention, the sterilization of wherein said fishpond, swimming pool sterilization are to make said fish or swimmer leave fishpond or swimming pool, fishpond or swimming pool are carried out disinfection again.
According to the method for second aspect present invention, wherein said medicament randomly is used with neutralizer.Said neutralizer is after carrying out disinfection with medicament according to the invention, extraordinarily go into 0.8～1.5 of available iodine (I) mole, preferably extraordinarily goes into 0.9～1.2, preferably extraordinarily goes into 1.0～1.2.In one embodiment, said neutralizer is selected from vitamin C, sodium thiosulfate and comprises their composition.
Third aspect present invention provides a kind of composition, wherein comprises ground, west iodine and optional biology acceptable carrier.
According to the composition of third aspect present invention, it is used for the described method of second aspect present invention.
According to the composition of third aspect present invention, it comprises west ground iodine 20-70% and auxiliary material 30-80%.In one embodiment, said composition is a granule, and said auxiliary material is thinner and adhesive, wherein thinner 25-79%, adhesive 1-5% (each material percentage amounts representes that all this material accounts for the percentage of composition total weight).In one embodiment; Said composition is a tablet; And wherein said auxiliary material is thinner, disintegrant, adhesive and lubricant, and wherein thinner is 20-70%, disintegrant 5-20%, adhesive 1-5% and lubricant 0.5-3% (each material percentage amounts representes that all this material accounts for the percentage of composition total weight).
According to the composition of third aspect present invention, wherein said thinner is selected from one or more in lactose, sucrose, mannitol, the easy molten mineral salt; Adhesive is selected from one or more in polyvidone, methylcellulose, the carboxymethyl cellulose; Disintegrant is selected from one or more in PVPP, sodium carboxymethyl starch, sodium bicarbonate and citric acid mixture or other effervesce Acid-Base system.
According to the composition of third aspect present invention, it has the described prescription like arbitrary embodiment.
Fourth aspect present invention provides a kind of medicine box product; It comprises first composition and second composition that physically is separated from each other; And the detail file that uses said first composition and the operation of second compositions for disinfection; Wherein said first composition is the described composition of third aspect present invention; Said second composition comprises neutralizer and optional biology acceptable carrier, and wherein said neutralizer is selected from vitamin C, sodium thiosulfate and combination thereof.
According to the medicine box product of fourth aspect present invention, wherein said detail file has been put down in writing the described method of second aspect present invention basically.
Medicine box product according to fourth aspect present invention; Wherein said detail file has been put down in writing drinking water, medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment, fishpond or swimming pool method of disinfecting, and this method consists essentially of following steps:
(a) supply drinking water, medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment, fishpond, swimming pool;
(b) randomly, during to medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment disinfected, the water of sterilization usefulness is provided;
(c) in the said drinking water of step (a), fishpond water, swimming pool water or the said water of step (b), add said first composition; To said drinking water, fishpond water or the disinfection of swimming pool water, perhaps use the said water of step (b) that is added with ground, west iodine to said medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment disinfection;
(d) add neutralizer in the drinking water after sterile-processed, fishpond water or the swimming pool water, perhaps optional uses neutralizer to the medicine equipment after sterile-processed, tableware bedding, vegetable and fruit, organism surface, environment.
According to the medicine box product of fourth aspect present invention, wherein said first composition adds in the entry, is 1～1000mg/L in its concentration in water of available iodine (I), preferred 10～500mg/L, preferred 10～250mg/L, preferred 10～200mg/L.
Medicine box product according to fourth aspect present invention; Wherein said second composition is after with said first compositions for disinfection; Neutralizer extraordinarily goes into 0.8～1.5 of available iodine (I) mole, preferably extraordinarily goes into 0.9～1.2, preferably extraordinarily goes into 1.0～1.2.
Of the present invention arbitrary aspect, wherein the characteristic that is had between two or more embodiments arbitrarily can make up each other, as long as they can be not conflicting; In addition, arbitrary technical characterictic of arbitrary aspect is equally applicable to this characteristic of others.Certainly when making up each other, necessary words can be done suitably to modify to individual features.
Do further to describe with characteristics to various aspects of the present invention below.
All documents that the present invention quoted from, their full content is incorporated this paper by reference into, and if the expressed implication of these documents and the present invention when inconsistent, be as the criterion with statement of the present invention.In addition; Various terms and phrase that the present invention uses have the general sense of well known to a person skilled in the art; Nonetheless; The present invention still hopes at this more detailed explanation and explanation to be done in these terms and phrase; Term of mentioning and phrase are as the criterion with the implication that the present invention was explained if any inconsistent with known implication.
The present invention improves the solvability of iodine in water through nanometer iodine technology, improves the stability and the excitant of Operand, can be widely used in the sterilization of the army and the people's drinking water, wound, medicine equipment, tableware bedding, vegetable and fruit and environment.
In the present invention, term " ground, west iodine " is meant the cyclodextrin inclusion compound of iodine.In the embodiment aspect the present invention is arbitrary; The west used cyclodextrin of ground iodine is selected from alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, dimethyl-, trimethyl beta-schardinger dextrin-, HP-beta-schardinger dextrin-, SBE-beta-schardinger dextrin-; Their derivative, or its combination.In one embodiment; The cyclodextrin inclusion compound of said iodine is potassium iodide and iodine with weight ratio 1: 0.1 to 1: 10 (preferred 1: 0.2 to 1: 5; Preferred 1: 0.5 to 1: 2.5, more preferably 1: 1 to 1: 2, for example about 1: 1.5) ratio with the cyclodextrin encapsulated inclusion compound that makes.In one embodiment, the cyclodextrin inclusion compound of said iodine is the inclusion compound that feeds intake and make with following proportioning: iodine is about 1.5～20%, potassium iodide is about 3.0～20%, cyclodextrin about 60～95.5%.In one embodiment, the cyclodextrin inclusion compound of said iodine is the inclusion compound of beta-schardinger dextrin-.In one embodiment, the cyclodextrin inclusion compound of said iodine is as making under " preparation of ground, (one) west iodine " item among CN1028485C (patent of invention specification, patent No. ZL90106682.6) the specification embodiment one.
In the present invention; Term " medicament "; For example mention " medicament " of indication in " ground, west iodine is in the purposes of the medicament that preparation is used for sterilizing "; Be meant any composition that comprises ground, west iodine; Comprise ground, west iodine in the said composition, can also comprise the biology acceptable carrier that one or more help this medicament moulding.
In the present invention; Term " biology acceptable carrier "; Be meant the avirulent carrier of biology, comprise the carrier that organisms such as mammal, bacterium, pathogenic microorganism are had no adverse effects, refer in particular to the particularly human carrier that has no adverse effects of mammal.
In the present invention, term " drinking water disinfection " is meant treats the water disinfection of drinking, and this water to be drunk can be anyly will be supplied in the water that mammal is drunk, and can be running water, river, lake water etc.When this drinking water is carried out disinfection; Can be directly to wherein adding west ground iodine or the composition of iodine with comprising the west; West ground iodine or to comprise the amount that the composition of ground, west iodine drops in the water be the amount that reaches following; Promptly in available iodine (I); The concentration of this available iodine (I) in water is 1～1000mg/L; Preferred 10～500mg/L, preferred 10～250mg/L, preferred 10～200mg/L.
In the present invention, term " medical apparatus sterilizing ", " sterilization of tableware bedding ", " vegetable and fruit sterilization ", " organism surface sterilization ", " environment disinfected " are meant and treat disinfections such as the medicine equipment of disinfecting, tableware bedding, vegetable and fruit, organism surface, environment.For the present invention; When these article or object are carried out disinfection; Can prepare a thimerosal earlier; The preparation of this thimerosal is the composition that in water (for example redistilled water, deionized water, running water, river, lake water, seawater etc.), adds west ground iodine or comprise ground, west iodine; West ground iodine or to comprise the amount that the composition of ground, west iodine drops in the water be the amount that reaches following; Promptly in available iodine (I); The concentration of this available iodine (I) in water is 1～1000mg/L; Preferred 10～500mg/L; Preferred 10～250mg/L, preferred 10～200mg/L.Use the thimerosal prepared to disinfections such as said medicine equipment, tableware bedding, vegetable and fruits then, for example soak, processing such as scouring, wiping; Can water be rinsed well by this medicine equipment, tableware bedding, vegetable and fruit etc. then; In case of necessity at last, can carry out neutralisation treatment to said thimerosal with neutralizer.Perhaps use the thimerosal of being prepared that said organism surface (for example scratch), environment (for example flood environment later) are carried out wiping, sprinkling etc. and disinfect then; In case of necessity, can carry out neutralisation treatment with neutralizer to said organism surface, environment again.
In the present invention, term " fishpond sterilization ", " swimming pool sterilization " are meant and treat disinfections such as the fishpond of disinfecting, swimming pool.This sterilization can be directly existing water body in fishpond, the swimming pool to be carried out disinfection, and promptly fish in making water body or animal directly to wherein adding ground, west iodine, after water body is sterile-processed, adds neutralizer and carry out neutralisation treatment again after for example the people leaves water body.Perhaps; This sterilization can be earlier the water in fishpond, the swimming pool to be discharged; In the body of pond, spray the thimerosal that contains west ground iodine or comprise the composition of ground, west iodine as indicated above then, treat the water flushing of the sterile-processed back of pond body or spray neutralizer that water washes again after neutralization.
In the present invention, term " is disinfected " and generally is to use west ground iodinate 1 minute～10 hours, preferred 10 minutes～5 hours, preferred 30 minutes～5 hours.
In the present invention; For example first aspect present invention is described; Phrase " said sterilization is that said medicament drops in the corresponding water and carries out disinfection; be 1～1000mg/L in its concentration in water of available iodine (I) wherein " is meant said medicament is put in the water with such concentration or amount; Be available iodine (I) meter, the west concentration of ground iodine in water is 1～1000mg/L.Need to prove that this concentration is not meant the actual concentrations in the water in the available iodine (I), the concentration but ground, west iodine theory feeds intake is because ground, west iodine has consumption after in dropping into water.
In one embodiment of the invention, said medicament is the unit dose drug preparation, and ground, said west iodine is in available iodine (being I); The amount of this available iodine (being I) in the unit dose drug preparation is 0.1-200mg; Preferred 0.2-150mg, preferred 0.25-100mg, preferred 0.5-50mg.
In one embodiment of the invention, ground, said west iodine is method preparation as described below: potassium iodide 5-25 gram (preferred 8-20 gram, preferred 10-15 gram are got in (1); For example about 12 grams), iodine 5-30 gram (preferred 8-25 gram; Preferred 10-25 gram, preferred 15-20 gram, for example about 18 grams); Add an amount of (20-100ml for example of water; Preferred 25-80ml, preferred 30-60ml, for example about 40ml) make its dissolving; Process iodine liquid, subsequent use; (2) get cyclodextrin (for example alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, dimethyl-, trimethyl beta-schardinger dextrin-, HP-beta-schardinger dextrin-, SBE-beta-schardinger dextrin-; Their derivative; Or its combination; Preferred beta-schardinger dextrin-and derivative thereof; Preferred beta-schardinger dextrin-, dimethyl-, trimethyl beta-schardinger dextrin-, HP-beta-schardinger dextrin-, SBE-beta-schardinger dextrin-) 25-250 gram (preferred 30-200 gram; Preferred 50-150 gram; Preferred 50-100 gram; For example about 75 grams); It is an amount of to add water, and the optional cyclodextrin that under heating, makes dissolves; (3) the iodine liquid of step (1) is joined in the cyclodextrin solution of step (2); Under preference temperature (for example 40-95 ℃; For example 50-95 ℃; For example 60-90 ℃) stir down (for example 30min-10 hour, for example 1-5 hour, for example about 2 hours); Cooling (for example being cooled to room temperature); Filter, drying promptly gets.
In one embodiment of the invention; Ground, described west iodine is meant the cyclodextrin inclusion compound of iodine, is selected from alpha-cyclodextrin inclusion compound, Benexate Hydrochloride, gamma-cyclodextrin inclusion compound, dimethyl-inclusion compound, trimethyl Benexate Hydrochloride, HP-Benexate Hydrochloride, the SBE-Benexate Hydrochloride one or more.Ground, west iodine preparation method can be with reference to the preparation of ground, " preparation method of compound xidi iodine sucked tablet " (Chinese patent 90106682.6) Chinese and Western iodine.In one embodiment, said west ground each composition of iodine and proportioning are following: iodine is about 1.5～20%, and potassium iodide is about 3.0～20%, cyclodextrin about 60～95.5%.In one embodiment, ground, said west iodine is to be processed by following composition and weight proportion: about 1.5～20 parts of iodine, about 3.0～20 parts of potassium iodide, about 60～95.5 parts of cyclodextrin.
The object of the present invention is to provide a kind of multifunctional nano iodine disinfectant, have efficient, spectrum, quick sterilization, toxicity is low, production technology is simple, production cost is low, applied range and advantage such as easy to use.
The present invention finds that ground, west iodine can be effective as this multifunctional nano iodine disinfectant, and it utilizes the molecule dispersion technology, in cyclodextrin encapsulated product, adds auxiliary materials such as thinner, adhesive by active component iodine and is prepared into the sterilization particle.Multifunctional nano iodine sterilization particle of the present invention can further be prepared into multiple formulations such as conventional tablet, effervescent tablet, is convenient to packing and use.Multifunctional nano iodine disinfectant good stability of the present invention, portably use conveniently, dosage is accurate.Time spent is as long as to be dissolved in a certain amount of water be exactly certain density thimerosal with multifunctional disinfecting particle or sterilization sheet.Utilize the molecule dispersion technology to process nanometer iodine as stated, and further process nanometer iodine sterilization sheet, after overcoming the bad performance of iodine, keep the bactericidal action of iodine, simultaneously easy to use.Can supply army, individual open-air disinfection of drinking water, can be used for the disinfection of drinking water after emergency such as the disasters such as earthquake, hurricane simultaneously; And the sterilization of wound, medicine equipment, tableware bedding, vegetable and fruit, fish jar water supply and environment.
Multifunctional nano iodine sterilization particle of the present invention can be made up of nanometer iodine 20-70% and auxiliary material 30-80%, and wherein auxiliary material is thinner and adhesive, wherein thinner 25-79%, adhesive 1-5%.Multifunctional nano iodine sterilization sheet of the present invention is made up of nanometer iodine 20-70% and auxiliary material 30-80%; Wherein auxiliary material is thinner, disintegrant, adhesive and lubricant, and wherein thinner is 20-70%, disintegrant 5-20%, adhesive 1-5% and lubricant 0.5-3%.
The described thinner of multifunctional disinfectant of the present invention for lactose, sucrose, mannitol, be prone in the molten mineral salt one or more; Adhesive is one or more in polyvidone, methylcellulose, the carboxymethyl cellulose; Disintegrant is one or more in PVPP, sodium carboxymethyl starch, sodium bicarbonate and citric acid mixture or other effervesce Acid-Base system.
Multifunctional disinfectant of the present invention has efficiently, spectrum, quick sterilization, toxicity are low, cheap, production technology simply reaches advantages such as production cost is low.
Beneficial effect of the present invention is embodied in, and under the situation that for example is used for drinking water disinfection, ground, west iodine has very good disinfection efficacy.
Embodiment
Can further describe the present invention through the following examples, yet scope of the present invention is not limited to following embodiment.One of skill in the art can understand, and under the prerequisite that does not deviate from the spirit and scope of the present invention, can carry out various variations and modification to the present invention.The present invention carries out generality and/or concrete description to the material and the test method that are used in the test.Though for realizing that employed many materials of the object of the invention and method of operating are well known in the art, the present invention still does to describe in detail as far as possible at this.
In following preparation embodiment part or experimental example part; As not mentioning in addition; Ground, described west iodine is like CN1028485C (patent of invention specification; Patent No. ZL90106682.6) " preparation of ground, (one) west iodine " ground, west iodine that makes down among the specification embodiment one; Through sodium thiosulfate titration, comprise 165mg available iodine (I) in the every gram material of this west ground iodine of preparation.
Essence of the present invention is to find that ground, west iodine is used for the Disinfection Effect under the condition according to the invention; No matter therefore ground, west iodine is to prepare in which way, those skilled in the art can expect fully openly that according to the present invention other alternative that obtains ground, west iodine also can realize the object of the invention.In the present invention, ground, west iodine can abbreviate CDI as.
In addition, in following test, use homemade povidone iodine tablet, it is that 2005 editions two the 823rd page of described povidone iodine of employing Chinese Pharmacopoeia are raw material, mixes compacting with lactose in flakes, and the labelled amount of every available iodine (I) is 50mg, 100mg or 250mg.
In addition, in following test, use lactose to prepare simple iodine liquid (being called lactose iodine liquid) as auxiliary material; Promptly get potassium iodide 12 grams; Place mortar, add water 40ml, add iodine 18 grams again; Grinding makes its whole dissolvings; Add water to 400ml, add lactose 75 grams, stirring and dissolving; Mend then and add water to 500ml, promptly get.
A, comprise the preparation of compositions of west ground iodine
Embodiment 1
| Component | Proportioning |
| CDI | 55g |
| Lactose | 45g |
| PVP(K-30) | In right amount |
Prepare multifunctional nano iodine sterilization particle according to following method, as the composition that contains ground, west iodine of the present invention:
(1) by the prescription proportioning, adds CDI and lactose, pulverize mixing;
(2) add 2%PVP (K-30) and prepare particle as adhesive, the encapsulation of aluminium paper bag, the labelled amount of every bag of available iodine (I) has 8 kinds of specifications, is respectively 5mg, 10mg, 25mg, 50mg, 100mg, 250mg, 500mg, 1000mg, promptly gets.
Embodiment 2
Prescription:
| Component | Proportioning |
| CDI | 50g |
| Lactose | 18g |
| Sucrose | 20g |
| PVPP | 10g |
| PEG-6000 | 2g |
Prepare sterilization sheet according to following method as the present composition:
(1) by each material of prescription proportioning, pulverizes mixing;
(2) add entry as wetting agent, the system softwood is granulated drying;
(3) particle is pressed into tablet, the labelled amount of every available iodine (I) has 6 kinds of specifications, is respectively 10mg, 25mg, 50mg, 100mg, 250mg, 500mg, and aluminium-plastic bubble plate packing promptly gets.
Embodiment 3
| Component | Proportioning |
| CDI | 50g |
| Lactose | 20g |
| Mannitol | 15g |
| Sodium carboxymethyl starch | 12g |
| PEG-4000 | 3g |
The method of reference implementation example 2 prepares tablet.
Embodiment 4
| Component | Proportioning |
| CDI | 53g |
| Lactose | 35g |
| PVPP | 10g |
| PEG-6000 | 2g |
The method of reference implementation example 2 prepares tablet.
Embodiment 5
| Component | Proportioning |
| CDI | 48g |
| Lactose | 20g |
| Citric acid | 10g |
| Sodium bicarbonate | 10g |
| PEG-6000 | 2g |
Prepare sterilization sheet according to following method as the present composition:
(1) by the prescription proportioning CDI, citric acid and 10g lactose, mixing;
(2) add entry as wetting agent, the system softwood is granulated drying;
(3) particle and all the other auxiliary materials with step (2) mixes, and is pressed into tablet, and the labelled amount of every available iodine (I) has 4 kinds of specifications, is respectively 25mg, 50mg, 100mg, 250mg, and aluminium-plastic bubble plate packing promptly gets.
B, experimental example part
Experimental example 1: the bactericidal effect that compares the Dobell and the polyvidone crystalline flake of iodine
The Dobell (every contains available iodine (I) is 100mg) and the self-control polyvidone crystalline flake of iodine (every contains available iodine (I) is 100mg) with embodiment 2 preparations experimentize.During use every kind of tablet is ground into fine powder respectively, measures the amount of available iodine (I), accurately take by weighing the tablet powder of the available iodine (I) that comprises respective amount then according to predetermined inventory, be ready for use on experimental test.
Use sodium thiosulfate to be neutralizer, its consumption is 1.0 times that corresponding iodine drops into mole.
Use fishpond water to be the sterilization sample, this fishpond water is from 2 cubic metres of fishpond water in the same fishpond, and has breeded fish existing January.
With reference to the document of Peng Qi (Peng Qi, etc., environment and health magazine, 2009,26 (6): 543) reported method, carries out the methodology checking and show on the methodology it is feasible, and neutralizer is to being tried bacterium and medium has no adverse effects.
Get some parts of the fishpond water that mixes, every part of 10L to the Dobell or the polyvidone crystalline flake of iodine that wherein add different amounts, makes the concentration of available iodine (I) in water be respectively 1mg/L, 10mg/L, 100mg/L, 500mg/L, 1000mg/L respectively, mixes.Be provided with simultaneously do not add reagents such as iodine same fishpond water as contrast.Get fishpond water 2L during respectively at 5 minutes, 10 minutes, 30 minutes, the neutralizer that adds dosis neutralisata makes neutralization, and the fishpond water of drawing after neutralizing is inoculated in the aseptic plate then, and agar pours into cultivation.(average n=3), and is observed each sample water body state (color or smell) of 30 minutes with respect to the percentage of the average growth bacterium number (cfu/ml) of control group to calculate each experimental group.Result such as table 1.
Table 1: the bactericidal effect of the Dobell and the polyvidone crystalline flake of iodine relatively
Experimental example 2: the bactericidal effect that compares the Dobell and the polyvidone crystalline flake of iodine
Basically the method for reference experiment example 1.
The Dobell (every contains available iodine (I) is 100mg) and the self-control polyvidone crystalline flake of iodine (every contains available iodine (I) is 100mg) with embodiment 2 preparations experimentize.During use every kind of tablet is ground into fine powder respectively, measures the amount of available iodine (I), accurately take by weighing the tablet powder of the available iodine (I) that comprises respective amount then according to predetermined inventory, be ready for use on experimental test.
Use sodium thiosulfate to be neutralizer, its consumption is 1.2 times that corresponding iodine drops into mole.
The water that uses is 50 liters of new system distilled water, to wherein adding Candida albicans, makes the concentration of bacterium in water reach 10
8, as the infected water of test usefulness.
With reference to the document of Peng Qi (Peng Qi, etc., environment and health magazine, 2009,26 (6): 543) reported method, carries out the methodology checking and show on the methodology it is feasible, and neutralizer is to being tried bacterium and medium has no adverse effects.
Get some parts of infected water, every part of 10L to the Dobell or the polyvidone crystalline flake of iodine or an amount of lactose iodine liquid that wherein add different amounts, makes the concentration of available iodine (I) in water be respectively 10mg/L, 100mg/L, 500mg/L respectively, mixes.Be provided with simultaneously do not add reagents such as iodine same infected water as contrast.Respectively at getting infected water 1L in 15 minutes, the neutralizer that adds dosis neutralisata makes neutralization, and the infected water of drawing then after the neutralization is inoculated in the aseptic plate, and agar pours into cultivation.Calculate each experimental group with respect to the percentage of the average growth bacterium number (cfu/ml) of control group (average, n=3).Result such as table 2.
Table 2: the bactericidal effect of Dobell
| Available iodine (I)/water | Dobell | The polyvidone crystalline flake of iodine | Lactose iodine liquid |
| 10mg/L | 74％ | 89％ | 81％ |
| 100mg/L | 33％ | 63％ | 47％ |
| 500mg/L | 9％ | 31％ | 13％ |
Claims (10)
1. the purposes of the west ground iodine medicament that is used for sterilizing in preparation.
2. according to the purposes of claim 1, wherein said sterilization is selected from: drinking water disinfection, medical apparatus sterilizing, the sterilization of tableware bedding, vegetable and fruit sterilization, organism surface sterilization, environment disinfected, fishpond sterilization, swimming pool sterilization.
3. according to each purposes of claim 1 to 2, wherein said sterilization is that said medicament drops in the corresponding water and carries out disinfection, and is 1～1000mg/L in its concentration in water of available iodine (I) wherein.
4. according to each purposes of claim 1 to 3, wherein said medicament randomly is used with neutralizer.
5. sterilization method, it carries out disinfection to drinking water, medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment, fishpond or swimming pool, and this method may further comprise the steps:
(i) west is provided iodine or the composition of iodine with comprising the west;
(ii) supply drinking water, medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment, fishpond, swimming pool;
(iii) randomly, during to medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment disinfected, the water of sterilization usefulness is provided;
The iodine or the composition of iodine with (iv) in the (ii) said drinking water of step, fishpond water, swimming pool water or the (iii) said water of step, adding the said west of step (i) with comprising the west; To said drinking water, fishpond water or the disinfection of swimming pool water, perhaps use the (iii) said water of step that is added with ground, west iodine to said medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment disinfection;
(v) add neutralizer in the drinking water after sterile-processed, fishpond water or the swimming pool water, perhaps optional uses neutralizer to the medicine equipment after sterile-processed, tableware bedding, vegetable and fruit, organism surface, environment.
6. according to the method for claim 5, wherein said west ground iodine or the composition that comprises ground, west iodine add in the entry, are 1～1000mg/L in its concentration in water of available iodine (I).
7. a composition wherein comprise ground, west iodine and optional biology acceptable carrier, and said composition is used for claim 5 or 6 described methods.
8. medicine box product; It comprises first composition and second composition that physically is separated from each other; And the detail file that uses said first composition and the operation of second compositions for disinfection; Wherein said first composition is the described composition of claim 7, and said second composition comprises neutralizer and optional biology acceptable carrier.
9. medicine box product according to Claim 8, wherein said detail file has been put down in writing drinking water, medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment, fishpond or swimming pool method of disinfecting, and this method consists essentially of following steps:
(a) supply drinking water, medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment, fishpond, swimming pool;
(b) randomly, during to medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment disinfected, the water of sterilization usefulness is provided;
(c) in the said drinking water of step (a), fishpond water, swimming pool water or the said water of step (b), add said first composition; To said drinking water, fishpond water or the disinfection of swimming pool water, perhaps use the said water of step (b) that is added with ground, west iodine to said medicine equipment, tableware bedding, vegetable and fruit, organism surface, environment disinfection;
(d) add neutralizer in the drinking water after sterile-processed, fishpond water or the swimming pool water, perhaps optional uses neutralizer to the medicine equipment after sterile-processed, tableware bedding, vegetable and fruit, organism surface, environment.
10. according to Claim 8 or 9 medicine box product, it is characterized in that,
Said first composition adds in the entry, is 1～1000mg/L in its concentration in water of available iodine (I); And/or
Said second composition is after with said first compositions for disinfection, and neutralizer is extraordinarily gone into 0.8～1.5 of available iodine (I) mole.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102281364A CN102349541A (en) | 2011-08-10 | 2011-08-10 | New application of iodine cyclodextrin inclusion compound |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011102281364A CN102349541A (en) | 2011-08-10 | 2011-08-10 | New application of iodine cyclodextrin inclusion compound |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103785366A (en) * | 2012-10-31 | 2014-05-14 | 沈阳药科大学 | Iodine/hydrophobic cyclodextrin clathrate and its preparation method and use |
| CN103918712A (en) * | 2014-04-20 | 2014-07-16 | 阎昭良 | Cleaning effervescent tablet for toilet things and tableware and preparation and application method thereof |
| CN113831424A (en) * | 2021-11-02 | 2021-12-24 | 山东华农生物制药有限公司 | Preparation method of cydiodine |
| CN114917267A (en) * | 2022-04-25 | 2022-08-19 | 杭州西子卫生消毒药械有限公司 | Iodine-containing disinfectant for skin and preparation method thereof |
| CN115152756A (en) * | 2022-06-07 | 2022-10-11 | 沈阳化工大学 | Clathrate compound disinfection tablet and preparation method thereof |
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| CN1239438A (en) * | 1996-01-22 | 1999-12-22 | 博士伦公司 | Dual neutralization system for iodine treatment of contact lenses |
| JP2003081724A (en) * | 2001-09-06 | 2003-03-19 | Misuzu Shokai:Kk | Environmental sterilizer and sliminess-preventing tool |
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| CN1073577A (en) * | 1991-12-23 | 1993-06-30 | 衡阳医学院 | Compound iodine |
| CN1175240A (en) * | 1994-12-15 | 1998-03-04 | 金伯利-克拉克环球有限公司 | Process and article for disinfecting water |
| CN1239438A (en) * | 1996-01-22 | 1999-12-22 | 博士伦公司 | Dual neutralization system for iodine treatment of contact lenses |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103785366A (en) * | 2012-10-31 | 2014-05-14 | 沈阳药科大学 | Iodine/hydrophobic cyclodextrin clathrate and its preparation method and use |
| CN103785366B (en) * | 2012-10-31 | 2016-08-03 | 沈阳药科大学 | A kind of iodine/hydrophobic cyclodextrin clathrate and its preparation method and application |
| CN103918712A (en) * | 2014-04-20 | 2014-07-16 | 阎昭良 | Cleaning effervescent tablet for toilet things and tableware and preparation and application method thereof |
| CN113831424A (en) * | 2021-11-02 | 2021-12-24 | 山东华农生物制药有限公司 | Preparation method of cydiodine |
| CN114917267A (en) * | 2022-04-25 | 2022-08-19 | 杭州西子卫生消毒药械有限公司 | Iodine-containing disinfectant for skin and preparation method thereof |
| CN114917267B (en) * | 2022-04-25 | 2023-04-11 | 杭州西子卫生消毒药械有限公司 | Iodine-containing disinfectant for skin and preparation method thereof |
| CN115152756A (en) * | 2022-06-07 | 2022-10-11 | 沈阳化工大学 | Clathrate compound disinfection tablet and preparation method thereof |
| CN115152756B (en) * | 2022-06-07 | 2024-01-16 | 沈阳化工大学 | Clathrate disinfection tablet and preparation method thereof |
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