CN100415100C

CN100415100C - Active disinfectant germicide and method for preparing same

Info

Publication number: CN100415100C
Application number: CNB2006100129304A
Authority: CN
Inventors: 王德昌; 王淑静; 刘卫权; 刘卫萍; 王金泰
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-07-06
Filing date: 2006-07-06
Publication date: 2008-09-03
Anticipated expiration: 2026-07-06
Also published as: CN1883273A

Abstract

The present invention relates to disinfecting germicide which takes iodine and benzalkonium bromide as main active components to be matched with other active factors, such as phosphoric acid, ethanol, lightyellow sophora root extract, etc. The disinfecting germicide is the disinfecting germicide with high efficiency, brute force, broad spectrum, safety and less stimulation, and has rapid sterilization, lasting sterilization, less dosage, no toxic or side effect on human bodies, and good killing effect on pathogenic microorganisms of livestock and poultry, susceptible virus bacteria in aquaculture and environment virus bacteria.

Description

Active disinfectant germicide and preparation method thereof

Technical field

The present invention relates to a kind of disinfectant, relating in particular to a kind of is the main effectively disinfectant of sterilization component with iodine, the invention still further relates to the preparation method of this disinfectant.

Background technology

Because iodine has very strong sterilizing power and very fast sterilization speed under sour environment, Operand becomes a kind of disinfectant of function admirable.But the shortcoming of Operand also is conspicuous, and is very little as the solvability in water, can not be mixed with water formulation and use; The inefficacy that easily distils of preparation instability, iodine; Iodine is stronger to the excitant of skin; Has xanthochromia or the like.

Present widely used Iodophor class disinfectant is to be carrier with organic polymer or surface reactive material mostly, by network structure or the micella that forms between carrier molecule, with the conformational effect in electronics and space with iodine " constraint " in wherein, thereby change the free state of iodine in general Operand, make its stability and bactericidal action enhancing, excitant and xanthochromia reduction.This product has been widely used in aspects such as the wild sterilization of partes corporis humani position, food, medicine equipment, environment and art, has wherein obtained using the most widely with the complex compound of polyvinylpyrrolidone (PVP) with iodine again.

Yet the chelated iodine preparation is not to be a kind of perfect disinfectant yet, is a kind of high molecular surfactant as PVP, mean molecule quantity 10000～70000, and than difficult for biological degradation, the long-term use, its residual accumulating can be caused environmental pollution; The chelated iodine preparation is after dilution, and original surface reactive material micella power can be destroyed, makes the stability decreases of active iodine, influences sterilization effect; Special needs to be pointed out is, what play sterilization in the chelated iodine preparation only is the free state iodine molecule that slowly releases from the PVP micelle, and PVP is a carrier as iodine molecule, purpose is to make iodine stable, itself does not have bactericidal action, therefore, the adding of PVP carrier will inevitably make the use cost of Operand and price increase.

Quaternary cationic surfactant is another kind of material with sterilization, in water, have positive charge, can be adsorbed in the surface of various fungies, bacterium and virus forcefully, form micelle, and progressively infiltrate cytoplasmic lipoid layer and albumin layer, change fungi, bacterium, viral somatic permeability, endobacillary enzyme, coenzyme and metabolism midbody product are overflowed, hinder the breathing and the glycolytic cycle of mushroom, also can make the structure generation sex change of albumen and enzyme simultaneously, the metabolism of destroy microorganisms, thus reach the effect of sterilization.Therefore be widely used as disinfectant, be applied to the sterilizing of aspects such as industry, medicine, building, household chemicals, oil-field brine processing and agricultural chemicals.The representative products of quaternary cationic surfactant is a benzalkonium bromide.

Though the quaternary ammonium salt disinfectant with safely, have no side effect and be celebrated, but weak point is that quaternary cationic surfactant Disinfection Effect when using separately is bad, usually be subjected to the influence of the factors such as kind, pH value, temperature, concentration and organic matter of microorganism easily, and quaternary cationic surfactant is easy to produce antibody-resistant bacterium after use.

Summary of the invention

The object of the present invention is to provide a kind of efficient, brute force, wide spectrum, safe activity disinfectant germicide, the present invention also aims to provide the preparation method of this disinfectant.

Disinfectant of the present invention is to be main active with iodine and benzalkonium bromide, is equipped with other active factorses and forms, and its component and content are:

Benzalkonium bromide 5%～45%

1% Radix Sophorae Flavescentis extractive liquid 1%～2%

Ethanol 5%～10%

Potassium iodide 0.1%～1%

Iodine 0.5%～3%

Phosphatase 11 %～3%

Water surplus,

All percentages are percetage by weight.

The concrete preparation method of disinfectant of the present invention is:

With part water potassium iodide is dissolved earlier, add iodine, stirring and dissolving 10min adds ethanol again, is stirred to iodine and dissolves fully; Order adds the water of benzalkonium bromide, phosphoric acid and surplus, is heated to 45 ℃, stirs 30min; Add 1% Radix Sophorae Flavescentis extractive liquid at last, stir 30min, make disinfectant.

After the disinfectant of making after stirring was preferably in and keeps 1h in the container, discharging was packed again.

The present invention utilizes the combination of quaternary cationic surfactant and iodine, given play to the powerful function of killing the virus, it can the oxidizing bacteria cytoplasm combine with the amino of protein, the protein active gene of oxidation virus, permeability by changing cell and make that beyond the region of objective existence oozes in the cell, solidifying protein, blocking its breeding or directly it is killed, thereby kill hydrophily effectively, lipophilic virus, bacterium, is a kind of efficient, safety, bland disinfectant.

Disinfectant of the present invention is the rufous thick liquid, the killing action that has moment for harmful bacterium and microorganism in the water body, as long as and the water contact process was greater than 0.25 second, the virus killing ability is 60～120 times of common iodine, sterilization rapidly, efficiently, sterilizing ability is lasting, directive property is high, consumption is few, and in water body, do not introduce new compound, no hazard residue thing, without any side effects to human body, for susceptible virus and bacteria and environment virus and bacteria in the pathogenic microorganismss of livestock and poultry and the aquaculture good killing action is arranged all.

Disinfectant of the present invention has certain broad spectrum activity, germ, virus, noxious bacteria gemma, the algae spore that can effectively kill the germ, virus of all kinds of harm humans and make a variation because of environmental deterioration; Can effectively kill harmful microorganisms such as the main anaphylactogen acarid of Susceptible population; Can also effectively kill and suppress germ viruses such as bird flu that acquired immune deficiency syndrome (AIDS), hepatitis, cholera and people livestock and poultry suffer from altogether, SARS.

Disinfectant molecular structure stabilized of the present invention, stable performance is being used below 90 ℃, is being preserved the loss variation can not take place, and the disinfection performance is not subjected to the influence of water pH value.

Disinfectant of the present invention is safe and reliable, and same target repeated multiple times is used, and target is not had injury, environment is not had harm.

Embodiment

Embodiment 1

Prescription:

Benzalkonium bromide 20%

1% Radix Sophorae Flavescentis extractive liquid 1%

Ethanol 5%

Potassium iodide 0.5%

Iodine 1%

Phosphoric acid 2%

Water 70.5%

Method for making:

Potassium iodide is dissolved with low amounts of water, and adding iodine behind the stirring and dissolving 10min, adds ethanol, is stirred to iodine is dissolved fully, and order adds benzalkonium bromide and phosphoric acid, adds the water of surplus again, is heated to 45 ℃, stirs 30min; Add 1% Radix Sophorae Flavescentis extractive liquid at last, stir 30min, place reactor to keep 1h, discharging is packaged to be finished product.

Embodiment 2

Prescription:

Benzalkonium bromide 40%

1% Radix Sophorae Flavescentis extractive liquid 2%

Ethanol 8%

Potassium iodide 1%

Iodine 2%

Phosphoric acid 2%

Water 45%

Method for making is with embodiment 1.

Embodiment 3

Prescription:

Benzalkonium bromide 30%

1% Radix Sophorae Flavescentis extractive liquid 2%

Ethanol 5%

Potassium iodide 0.5%

Iodine 1%

Phosphoric acid 2%

Water 59.5%

Method for making is with embodiment 1.

Embodiment 4

Prescription:

Benzalkonium bromide 25%

1% Radix Sophorae Flavescentis extractive liquid 1%

Ethanol 10%

Potassium iodide 1%

Iodine 2%

Phosphatase 11 %

Water 60%

Method for making is with embodiment 1.

Claims

1. active disinfectant germicide, its component and content are:

Benzalkonium bromide 5%～45%

1% Radix Sophorae Flavescentis extractive liquid 1%～2%

Ethanol 5%～10%

Potassium iodide 0.1%～1%

Iodine 0.5%～3%

Phosphatase 11 %～3%

Water surplus,

All percentages are percetage by weight.

2. the preparation method of claim 1 disinfectant is according to following step preparation:

Potassium iodide is separated with part is water-soluble;

Add iodine, stirring and dissolving 10min;

Add ethanol, be stirred to iodine and dissolve fully;

Order adds the water of benzalkonium bromide, phosphoric acid and surplus, is heated to 45 ℃, stirs 30min;

Add 1% Radix Sophorae Flavescentis extractive liquid, stir 30min, make disinfectant.

3. the preparation method of disinfectant according to claim 2, it is characterized in that the disinfectant of making keeps 1h in container after, discharging packing again.