CN101743971B - Compound disinfector of peroxyacetic acid and glutaric dialdehyde - Google Patents
Compound disinfector of peroxyacetic acid and glutaric dialdehyde Download PDFInfo
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- CN101743971B CN101743971B CN 200910263970 CN200910263970A CN101743971B CN 101743971 B CN101743971 B CN 101743971B CN 200910263970 CN200910263970 CN 200910263970 CN 200910263970 A CN200910263970 A CN 200910263970A CN 101743971 B CN101743971 B CN 101743971B
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Abstract
The invention relates to a disinfector, in particular to a compound disinfector of peroxyacetic acid and glutaric dialdehyde. The compound disinfector is mixed liquid, comprising peroxyacetic acid, hydrogen peroxide, glutaric dialdehyde, purified water, stabilizing agent and synergist. The compound disinfector is prepared by the following steps: taking 75-90ml of peroxyacetic acid, 10-23ml of hydrogen peroxide, 0.2-3ml of glutaric dialdehyde, 0.5-5ml of polyoxyethylene fatty alcohol ether and 0.1-3g of sodium pyrophosphate respectively, mixing fully and stirring evenly. The invention has the characteristics of high speed, high efficiency, long acting, low cost, small toxicity, no corrosiveness, no pollution and strong anti-jamming ability. The disinfector can quickly and thoroughly kill microorganisms in animal colony houses and the environment and has a special killing function to Avian influenza viruses.
Description
Technical field
The present invention relates to a kind of disinfectant, be specially a kind of compound disinfector of peroxyacetic acid and glutaric dialdehyde.
Background technology
Sterilization is the effective means of killing the various pathogenic microorganisms in the environment.Peracetic acid, chlorine dioxide, Iodophor, chlorine-containing disinfectant, aldehyde disinfectant etc. have good killing effect to pathogenic microorganism under experiment condition, but these single component disinfectants are subject to the impact of nature, environmental temperature, organic matter existence, pH value etc. in actual use, can not reach desirable Disinfection Effect, exist inevitable shortcoming.After decomposing, the oxidation such as Peracetic acid, hydrogen peroxide class disinfectant produces the various free radicals such as OH base, active oxygen derivative, the permeability barrier of destroy microorganisms, protein, amino acid, enzyme and DNA etc. cause microbial death, the advantage of this type of disinfectant is that fungicidal spectrum is wide, effectively working concentration is low, speed of action is fast, be subjected to environmental factor and organic substance influence larger but exist, copper, stainless steel, galvanized iron etc. are corrosive, the shortcoming such as sterilization effective acting time is short.Glutaraldehyde can form side chain with the fat connection residue that mureinlipoprotein occurs in crosslinked and the cell wall phosphoric acid, thereby closing cell's wall, hinder microorganism to the absorption of nutriment and the discharge of refuse, the environment disinfected that can be used for livestock and poultry and colony house, its advantage is namely to have superpower bactericidal action under low concentration, the normal temperature, can be quickly dissolved into water, properties of product are stable, drug effect can keep for two weeks, toxic and side effect is little, can not damage vessel and disinfection apparatus, sterilizing ability is not subject to the impact of external environment, can be widely used in various occasions.But this disinfectant corrosivity is strong, has stronger excitant, glutaraldehyde need can reach the shortcomings such as high level disinfection in 30 minutes to people and animals.
For these reasons, the technical staff constantly attempts utilizing the characteristic of variety classes disinfectant and the synergy between them to carry out proportioning, and that development has is rapid, efficient, long-acting, low-cost, stable in properties and the compound disinfectant that can not damage and pollute environment.The technology of the sterilization of for example making take hydrogen peroxide and acetic acid as major ingredient is on the books, for example: application (patent) number: 200510042902.2 disclose a kind of compound peroxide acid sterilizing agent and processing technology is that following raw material and technique are prepared from: 1. raw material: hydrogen peroxide: 55%～70% acetic acid: 12%～23% sulfuric acid: 2%～4% is sad: 1%～2%, and surfactant 2%～11% organic solvent 4%～17% is made the compound peroxide acid sterilizing agent that contains Peracetic acid, Peroxycaprylic acid, hydrogen peroxide.The patent No. is 200810053995.2 also to disclose a kind of sterilization process, has spoken of and has utilized acetic acid 25-30 part and hydrogen peroxide 12-20 to use as disinfectant (generating corresponding Peracetic acid).In the existing bibliographical information, the general and quaternary ammonium salt of glutaraldehyde prepares composite disinfectant as raw material.
Summary of the invention
The present invention uses the upper defective that exists in order to overcome the single disinfection method agent, according to the synergistic effect of variety classes disinfectant, provides a kind of compound disinfector of peroxyacetic acid and glutaric dialdehyde.
The present invention is realized by following technical scheme, a kind of compound disinfector of peroxyacetic acid and glutaric dialdehyde is comprised of following raw materials according: Peracetic acid 75～90 parts by volume, hydrogen peroxide 10～23 parts by volume, glutaraldehyde 0.2～3 parts by volume, polyoxyethylene aliphatic alcohol ether 0.5～5 parts by volume, sodium pyrophosphate 0.1～3 mass parts.Corresponding 1 parts by volume of 1 mass parts wherein, the corresponding 1ml of 1g for example, the corresponding 1L of 1kg.
Specific implementation process is: get 75～90 parts after with purified water Peracetic acid stoste being diluted to 2%, add successively hydrogen peroxide and glutaraldehyde, polyoxyethylene aliphatic alcohol ether adds sodium pyrophosphate 0.1～3g at last again, and fully stirring and evenly mixing gets final product.What the used raw material of the present invention all can be bought from the market arrives.
Peracetic acid (CH
3COOOH) claim again peracetic acid, be strong oxidizer, colourless transparent liquid, soluble in water, alcohol and sulfuric acid.Peracetic acid is met organic matter or enzyme is namely emitted nascent oxygen, and this nascent oxygen is realized bactericidal action by two kinds of approach, and the one, make the bacterium protein sex change, solidify; The 2nd, by the active gene of redox reaction infringement zymoprotein, the activity of inhibitory enzyme, or because of chemical constitution similar to metabolite, competition or non-competing with the enzyme combination activity of inhibitory enzyme, Peracetic acid has good bactericidal effect.
Hydrogen peroxide, the popular name hydrogen peroxide, molecular formula is H
2O
2, commercially available hydrogen peroxide concentration is 30%.Hydrogen peroxide is a kind of strong oxidizer, and its virus killing principle is: H
2O
2By decomposing the various free radicals of rear generation, finally cause microbial death such as permeability barrier, protein, amino acid, enzyme and the DNA etc. of the destroy microorganisms such as OH base, active oxygen derivative.
Glutaraldehyde is a kind of 5 carbon bisacetal compounds, and molecular formula is C
5H
8O
2, have the typical chemical reaction of aldehydes.Sterilizing mechanisms mainly relies on aldehyde radical, and Main Function can make it alkylation in thin base, hydroxyl, carboxyl and the amino of mycoprotein, causes that protein coagulating causes bacterium dead.
Peracetic acid and hydrogen peroxide are as strong oxidizer, glutaraldehyde is as the protein coagulating agent, composite rear formation aldehyde peroxide, strengthen bactericidal action, the lower stability that can strengthen Peracetic acid of the simultaneously a large amount of existence of hydrogen peroxide, three kinds of disinfectants not only can efficiently be killed virus to sterilize but also exist mutually and be acted synergistically, and the effect of oxidation class disinfectant is strong, the virus killing sterilization rapidly, but be subject to organic substance influence, the glutaraldehyde Disinfection Effect is subjected to organicly to affect littlely, and sterilization is long effective acting time, and it compositely can be improved Disinfection Effect.
Disinfectant provided by the invention can be applicable to the sterilization of the various aquacultures of animal and veterinary widely, can not damage and pollutes environment, and environmental protection and the pesticide resistance that solves microorganism are all had far reaching significance.Compare with existing single component disinfectant, the present invention has following characteristics and advantage:
1. speed of action is fast, killing power is strong
(1) avian influenza virus (AIV) Disinfection Effect obviously is better than one-component, 10000 times of diluting effect 10min of disinfectant or the AIV of 5000 times of diluting effect 5min deactivation more than 99.99%.Contain Peracetic acid and hydrogen peroxide effect 10min with dosage with this disinfectant, glutaraldehyde effect 5min, AIV that can only deactivation 99.97%.
(2) to bacterium, equal complete kill vegetative forms of bacteria in 5～30min can effectively be killed cured sample bacillus gemma in the 30min, can reach sterilization effect.
2. acting duration is long
Effective duration of sterilization of 10000 dilutions is 48h, and the disinfectant working concentration doubles to make effective sterilization duration to extend to 72h.Inactivation ratio to pathogenic microorganism is significantly higher than Peracetic acid, glutaraldehyde and hydrogen peroxide, has prolonged effective sterilization duration.
3. the little non-corrosiveness of toxicity
The toxicity test of this product per os, skin, eyes: show that the true border of compound disinfectant is nontoxic; Skin is belonged to subexcite, harmless to human-body safety.Corrosion test shows stainless steel, carbon steel, copper immersion genus no corrosion.
4. stable in properties, anti-external interference ability is strong, and compound disinfectant is not subjected to organic impact the in temperature, pH value and the environment substantially on the inactivation ratio of microorganism.
5. cost is low
Compound disinfectant is reaching under the identical Disinfection Effect condition tested microorganism, and cost is 4%～21% of disinfectant bulk drug cost.
6. this Recipe is simple, extremely is conducive to carry out suitability for industrialized production.
This disinfectant shows through experimental studies results in a few years: this compound disinfectant has significant deactivation to pathogenic microorganisms such as AIV virus, Escherichia coli.
With scheme: Peracetic acid 80～85 parts by volume, hydrogen peroxide 15～20 parts by volume, glutaraldehyde 1～2 parts by volume, polyoxyethylene aliphatic alcohol ether 3～4 parts by volume, sodium pyrophosphate 1～2 mass parts.Be concrete experimental subjects, the results are shown in following table:
Table 1 disinfectant is to the deactivation result of AIV
The qualitative sterile test result of table 2 compound disinfectant
Embodiment
Embodiment 1: gets 75ml after with purified water Peracetic acid stoste being diluted to 2%, adds successively hydrogen peroxide 20ml and glutaraldehyde 3ml, and polyoxyethylene aliphatic alcohol ether 2ml, making its final volume is 100ml, adds sodium pyrophosphate 0.6g again, fully stirring and evenly mixing gets final product.
Embodiment 2: gets 82ml after with purified water Peracetic acid stoste being diluted to 2%, adds successively hydrogen peroxide 15ml and glutaraldehyde 1.5ml, and polyoxyethylene aliphatic alcohol ether 1.5ml, making its final volume is 100ml, adds sodium pyrophosphate 1g again, fully stirring and evenly mixing gets final product.
Embodiment 3: gets 85ml after with purified water Peracetic acid stoste being diluted to 2%, adds successively hydrogen peroxide 13ml and glutaraldehyde 1ml, and polyoxyethylene aliphatic alcohol ether 1ml, making its final volume is 100ml, adds sodium pyrophosphate 1.6g again, fully stirring and evenly mixing gets final product.
Embodiment 4, get 90ml after with purified water Peracetic acid stoste being diluted to 2%, add successively hydrogen peroxide 10ml and glutaraldehyde 3ml, and polyoxyethylene aliphatic alcohol ether 0.5ml adds sodium pyrophosphate 3g again, and fully stirring and evenly mixing gets final product.
Embodiment 5, get 75ml after with purified water Peracetic acid stoste being diluted to 2%, add successively hydrogen peroxide 23ml and glutaraldehyde 0.2ml, and polyoxyethylene aliphatic alcohol ether 5ml adds sodium pyrophosphate 0.1g again, and fully stirring and evenly mixing gets final product.
Claims (2)
1. compound disinfector of peroxyacetic acid and glutaric dialdehyde, it is characterized in that proportionally being formed by following raw materials according: Peracetic acid 75～90 parts by volume, hydrogen peroxide 10～23 parts by volume, glutaraldehyde 0.2～3 parts by volume, polyoxyethylene aliphatic alcohol ether 0.5～5 parts by volume and sodium pyrophosphate 0.1～3 mass parts, corresponding 1 parts by volume of 1 mass parts wherein, the corresponding 1ml of 1g.
2. compound disinfector of peroxyacetic acid and glutaric dialdehyde according to claim 1, it is characterized in that proportionally being formed by following raw materials according: Peracetic acid 80～85 parts by volume, hydrogen peroxide 15～20 parts by volume, glutaraldehyde 1～2 parts by volume, polyoxyethylene aliphatic alcohol ether 3～4 parts by volume and sodium pyrophosphate 1～2 mass parts.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910263970 CN101743971B (en) | 2009-12-31 | 2009-12-31 | Compound disinfector of peroxyacetic acid and glutaric dialdehyde |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910263970 CN101743971B (en) | 2009-12-31 | 2009-12-31 | Compound disinfector of peroxyacetic acid and glutaric dialdehyde |
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|---|---|
| CN101743971A CN101743971A (en) | 2010-06-23 |
| CN101743971B true CN101743971B (en) | 2013-02-06 |
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|---|---|---|---|
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109699686A (en) * | 2019-01-07 | 2019-05-03 | 甘肃康承动物保健有限公司 | A kind of disinfectant for killing avian influenza virus |
| CN112244040B (en) * | 2020-11-16 | 2022-01-18 | 河南亿丰化学有限公司 | Hydrogen peroxide silver ion composite disinfectant |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005014777A2 (en) * | 2002-10-16 | 2005-02-17 | Board Of Regents, The University Of Texas System | Methods and compositions for increasing the efficacy of biologically-active ingredients |
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- 2009-12-31 CN CN 200910263970 patent/CN101743971B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005014777A2 (en) * | 2002-10-16 | 2005-02-17 | Board Of Regents, The University Of Texas System | Methods and compositions for increasing the efficacy of biologically-active ingredients |
Non-Patent Citations (1)
| Title |
|---|
| 马圆月、王鸿儒.消毒剂概述.《广州轻工业》.2008,22-23、33. * |
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