CN105532660B - A kind of compound disinfectant and its application - Google Patents
A kind of compound disinfectant and its application Download PDFInfo
- Publication number
- CN105532660B CN105532660B CN201610075150.8A CN201610075150A CN105532660B CN 105532660 B CN105532660 B CN 105532660B CN 201610075150 A CN201610075150 A CN 201610075150A CN 105532660 B CN105532660 B CN 105532660B
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- Prior art keywords
- ammonium chloride
- chloride
- dimethyl
- ammonium
- benzyl
- Prior art date
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 36
- 150000001875 compounds Chemical class 0.000 title claims abstract description 20
- -1 alkyl dimethyl ethylbenzyl ammonium chloride Chemical compound 0.000 claims abstract description 64
- 150000001299 aldehydes Chemical class 0.000 claims abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 27
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 25
- 239000002994 raw material Substances 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 244000144977 poultry Species 0.000 claims abstract description 14
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 14
- 239000004094 surface-active agent Substances 0.000 claims abstract description 12
- 239000003960 organic solvent Substances 0.000 claims abstract description 6
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 16
- RCTOVWPTGOZSPJ-UHFFFAOYSA-N benzyl(ethyl)azanium;chloride Chemical compound Cl.CCNCC1=CC=CC=C1 RCTOVWPTGOZSPJ-UHFFFAOYSA-N 0.000 claims description 12
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 claims description 12
- 244000144972 livestock Species 0.000 claims description 12
- YWFWDNVOPHGWMX-UHFFFAOYSA-N n,n-dimethyldodecan-1-amine Chemical compound CCCCCCCCCCCCN(C)C YWFWDNVOPHGWMX-UHFFFAOYSA-N 0.000 claims description 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 8
- 235000019270 ammonium chloride Nutrition 0.000 claims description 8
- 229960000228 cetalkonium chloride Drugs 0.000 claims description 7
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 6
- 229940015043 glyoxal Drugs 0.000 claims description 6
- RLWBFEDPHGDVFT-UHFFFAOYSA-M (4-ethylphenyl)methyl-hexadecyl-dimethylazanium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)Cc1ccc(CC)cc1 RLWBFEDPHGDVFT-UHFFFAOYSA-M 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 5
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 claims description 5
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical group [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 claims description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 4
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Natural products CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- DLNWMWYCSOQYSQ-UHFFFAOYSA-M benzyl-hexadecyl-dimethylazanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 DLNWMWYCSOQYSQ-UHFFFAOYSA-M 0.000 claims description 3
- IHDIFQKZWSOIBB-UHFFFAOYSA-M dodecyl-[(4-ethylphenyl)methyl]-dimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=C(CC)C=C1 IHDIFQKZWSOIBB-UHFFFAOYSA-M 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- HVUMOYIDDBPOLL-UHFFFAOYSA-N 2-(3,4-Dihydroxyoxolan-2-yl)-2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)C1OCC(O)C1O HVUMOYIDDBPOLL-UHFFFAOYSA-N 0.000 claims description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims description 2
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 claims description 2
- 229920001219 Polysorbate 40 Polymers 0.000 claims description 2
- 235000004443 Ricinus communis Nutrition 0.000 claims description 2
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 claims description 2
- GMQYYIJHOOQFIW-UHFFFAOYSA-M [Cl-].CCCCCCCCCCCCCCCCCCC([N+](C)(C)CC)C1=CC=CC=C1 Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCC([N+](C)(C)CC)C1=CC=CC=C1 GMQYYIJHOOQFIW-UHFFFAOYSA-M 0.000 claims description 2
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims description 2
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 claims description 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 2
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 235000019441 ethanol Nutrition 0.000 claims description 2
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 claims description 2
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- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 claims description 2
- 229940101027 polysorbate 40 Drugs 0.000 claims description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- HQKLQUDDQQLKFS-UHFFFAOYSA-N CCCCCCCCCCCCCCCCCCBr(C)(C)C Chemical compound CCCCCCCCCCCCCCCCCCBr(C)(C)C HQKLQUDDQQLKFS-UHFFFAOYSA-N 0.000 claims 1
- CXRFDZFCGOPDTD-UHFFFAOYSA-M Cetrimide Chemical compound [Br-].CCCCCCCCCCCCCC[N+](C)(C)C CXRFDZFCGOPDTD-UHFFFAOYSA-M 0.000 claims 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 claims 1
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 claims 1
- XXJLQQRZZGAIGT-UHFFFAOYSA-N benzyl(methyl)azanium;bromide Chemical compound [Br-].C[NH2+]CC1=CC=CC=C1 XXJLQQRZZGAIGT-UHFFFAOYSA-N 0.000 claims 1
- VZWMKHUMEIECPK-UHFFFAOYSA-M benzyl-dimethyl-octadecylazanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 VZWMKHUMEIECPK-UHFFFAOYSA-M 0.000 claims 1
- OCBHHZMJRVXXQK-UHFFFAOYSA-M benzyl-dimethyl-tetradecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 OCBHHZMJRVXXQK-UHFFFAOYSA-M 0.000 claims 1
- SXPWTBGAZSPLHA-UHFFFAOYSA-M cetalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SXPWTBGAZSPLHA-UHFFFAOYSA-M 0.000 claims 1
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 claims 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005909 ethyl alcohol group Chemical group 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
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- 239000008159 sesame oil Substances 0.000 claims 1
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- CEYYIKYYFSTQRU-UHFFFAOYSA-M trimethyl(tetradecyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+](C)(C)C CEYYIKYYFSTQRU-UHFFFAOYSA-M 0.000 claims 1
- 241001465754 Metazoa Species 0.000 abstract description 3
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- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 description 22
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- QDYLMAYUEZBUFO-UHFFFAOYSA-N cetalkonium chloride Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 QDYLMAYUEZBUFO-UHFFFAOYSA-N 0.000 description 6
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- 238000002791 soaking Methods 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 210000004215 spore Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
- HNBDQABBWNOTRU-UHFFFAOYSA-N thalline Chemical compound C1=CC=[Tl]C=C1 HNBDQABBWNOTRU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to disinfection field for animals, specially a kind of compound disinfectant and its application.The composition of each raw material is aldehydes 0.1 20%, alkyl dimethyl ethylbenzyl ammonium chloride by quality ratio in the compound disinfectant（Alkyl dimethyl ethyl benzyl ammonium chloride）0.5 25%, single-stranded quaternary ammonium salt 0.5 25%, surplus are surfactant, organic solvent, water composition, each component ratio total 100%.This disinfectant has many advantages, such as that efficient, corrosivity is small, for the disinfection of poultry environment disinfection, equipment disinfection etc., there is vast market prospect and value.
Description
Technical field
The invention belongs to disinfectant preparation field, especially livestock and poultry cultivation, aquaculture sterilizing field, specially one
Kind compound disinfectant and its application.
Background technology
Current livestock and poultry breeding industry comes into scale, intensive, automation and mechanization developing stage, largely
Livestock and poultry are clustered together, the probability of the environmental degradation for increasing livestock and poultry cultivation of high degree, and microbiological contamination occurs.Institute
It is to restrict one of the principal element of livestock and poultry breeding industry development with the disease caused by bacterium, virus, is made every year to livestock and poultry breeding industry
At very big economic loss.Influence the sound development of aquaculture industry of China.
The disinfectant type occurred currently on the market is various, is divided by its property：Iodine class, bases, halogen, phenols, aldehyde
Class, oxidants, surfactant-based etc..
It is a kind of active alkylating agent effect that the common aldehyde disinfectant of aldehydes, which has formaldehyde and glutaraldehyde, such disinfection principle,
Amino, carboxyl, hydroxyl in microprotein and sulfydryl keep microorganism dead to destroy protein molecule.Formaldehyde has
There is extremely strong sterilizing power, generated gas carries out fumigation after being combined with oxidant (potassium permanganate etc.), is sealed behind sky column
The best disinfectant of enclosed disinfection.But formaldehyde penetrating odor is strong, has strong impulse effect to skin, mucous membrane, is chiefly used in soaking
Bubble, fumigation；Glutaraldehyde smell is less, and bactericidal effect is 2~10 times strong compared with formaldehyde, and penetrating power is strong, to any bacterium, disease
The brood cell etc. of poison, mould and stubbornness has extremely strong killing effect, it may also be used for fumigation, because it should not be poly- in body surface
It closes, therefore effect is better than formaldehyde.
Quaternary ammonium disinfectant is a kind of ionic surface active agent, belongs to the organic compound of synthesis, there is single-stranded quaternary ammonium salt
With two kinds of double-chain quaternary ammonium salt.Quaternary ammonium disinfectant, they belong to cationic surfactant, have sterilization and decontamination.
It is poor to gemma effect, belong to low effect disinfectants.Due to this kind of compound can be changed bacterial cell membrane permeability, often by they with
Other disinfectants are compounded to improve its bactericidal effect and sterilization speed.
Chlorine-containing agent, that is, bleaching powder, chlorine dioxide, sodium hypochlorite etc..Such disinfectant wide sterilization spectrum, to bacterial propagule,
Virus, fungal spore and bacterial spore have killing effect, but volatility is big, there is the stink of chlorine, irritant to mucous membrane, and one
As should not all deposit long.
Iodic agent mainly has iodine, Iodophor etc., such as it is commercially available there are hundred bacterium to disappear, Iodophor.Such disinfectant wide sterilization spectrum.It is right
Gemma has certain killing effect, but needs high level, efficacy wanes and is easy to decompose in light in the presence of organic matter.It can use
It is sterilized in band pig, animal house sky column is washed one's hands, the disinfection of apparatus, haulage vehicle etc..
There are commonly caustic soda (94% or more sodium hydroxides) for bases.The most commonly used is caustic soda on general pig farm, because of its valence
It is honest and clean, stability is good, can rapidly permeate into livestock and poultry column seam and the organic matters such as fecaluria, has expansion, plays dirt, can reach decontamination,
Cleaning and killing bacterium, virus, the function of worm's ovum are rinsed when generally cleaning column home, feed trough after can drenching immersion with buck again,
Still be added in front door, people, vehicle disengaging big pool, animal house doorway sterilization pool in.Because its corrosivity is strong, empty column is needed to use.
Peroxide has Strong oxdiative ability, and various microorganisms are very sensitive to it, can be by all microorganism killings.It crosses
Fluoroacetic acid, hydrogen peroxide, chlorine dioxide and ozone are domestic common peroxide disinfectant.Wherein, Peracetic acid is killed
Bacterium ability is most strong, and use is most extensive.Such disinfectant wide sterilization spectrum has killing effect to bacterial spore, virus, mould etc.,
But irritant tart flavour, volatile, organic matter has livestock and poultry column home certain corrosivity in the presence of that can reduce its bactericidal effect.
These disinfectants all have the advantage and disadvantage of itself, therefore, required for livestock and poultry farm it is a kind of it is efficient, non-corrosive,
The disinfectant of wide spectrum occurs.
Invention content
The purpose of the present invention is in view of the above technical problems, propose a kind of livestock and poultry cultivation place disinfection compound disinfectant and
It is applied.The ingredient of the disinfectant is less and is easy to get, the broad-spectrum disinfectant product that production cost is low, efficient, corrosivity is small.
To achieve the goals above, the specific technical solution of the present invention is：
A kind of compound disinfectant, the compound disinfectant include the raw material of following mass percentage：
Aldehydes 0.1-40%, alkyl dimethyl ethylbenzyl ammonium chloride (Alkyl dimethyl ethyl benzyl
Ammonium chloride) 0.5-40%, double-chain quaternary ammonium salt 0.5-40%, surplus is surfactant, organic solvent, water structure
At each component ratio total 100%.
Preferably, which includes the raw material of following mass percentage：
Purified water is to full dose volume.
Preferably, the compound disinfectant includes the raw material of following mass percentage：
Purified water is to full dose volume.
Preferably, aldehydes of the present invention is any one or a few in o-phthalaldehyde, glutaraldehyde, glyoxal
Mixture.
Preferably, alkyl dimethyl ethylbenzyl ammonium chloride (Alkyl dimethyl ethyl of the present invention
Benzyl ammonium chloride) it is dodecyl dimethyl ethylbenzylammonium chloride, dodecyldimethylamine base benzyl ethyl
Arbitrary two in ammonium chloride, cetyl dimethylethyl benzyl ammonium chloride and octadecyldimethyl ethylbenzylammonium chloride
Kind or two or more mixtures.
Such as：Dodecyl dimethyl ethylbenzylammonium chloride, dodecyldimethylamine base ethylbenzylammonium chloride and 16
Alkyl dimethyl ethylbenzyl ammonium chloride mixing quality percentage is 40%：50%：10%, hereinafter abbreviated as alkyl dimethyl second
Base benzyl ammonium chloride (C12:C14:C16=40:50:10).
Preferably, single-stranded quaternary ammonium salt of the present invention is dodecyl benzyl dimethyl ammonium chloride, dodecyldimethylamine
Base benzyl ammonium chloride, cetalkonium chloride, stearyl dimethyl benzyl ammonium chloride, dodecyl dimethyl
Benzylphosphonium Bromide ammonium, tetradecyl dimethyl benzyl ammonium, cetyl dimethyl benzyl ammonium bromide, octadecyldimethyl benzyl
Two or more mixture in base ammonium bromide.Such as：Dodecyl dimethyl benzyl ammonium bromide, myristyl benzyl dimethyl bromination
The mass percent of ammonium and cetyl dimethyl benzyl ammonium bromide is 40%：50%：10%, hereinafter abbreviated as alkyl dimethyl
Benzylphosphonium Bromide ammonium (C12:C14:C16=40:50:10), embodiment part all same.
Preferably, surfactant of the present invention is aliphatic acid polyethenoxy ether, nonylphenol polyoxyethylene ether, castor-oil plant
Oily polyoxyethylene ether, polyethylene glycol 400 monoleate, span 40, sorbester p18, polysorbate40, is spat polyethylene glycol 400 dioleic acid ester
Any one or a few mixture in temperature 60 and Tween 80.
Preferably, organic solvent of the present invention is appointing in ethyl alcohol, isopropanol, normal propyl alcohol, diethylene glycol (DEG) and cyclohexanol
The mixture for one or more of anticipating.
Preferably, heretofore described disinfectant is applied to the disinfection in livestock and poultry cultivation place.
Aldehydes is a kind of high effect disinfectants, even certain to bacterial propagule, fungi, mycobacteria, virus, bacterial spore
Parasite has very strong killing effect.O-phthalaldehyde have it is fat-soluble, can be reacted with the lipoprotein on gemma outermost layer.
Quaternary ammonium salt is that in beasts, birds and aquatic products cultivation application, relatively widely a kind of disinfectant, quaternary ammonium salt belong to cation form to one kind
Face activating agent.The sterilization mechanism of single-stranded quaternary ammonium salt is to be adsorbed onto phage surface, and hydrophobic group inserts mankind's lipid layer, changes cell wall, film
Permeability, intracellular organic matter leakage, enzyme or protein denaturation, last thalline is dead.
The positive effect of the present invention is embodied in：
(1), efficient, quick-acting, it can be used for poultry environment disinfection, equipment disinfection etc.；
(2), in the present invention, aldehyde disinfectant and quaternary ammonium salt, which have, mutually to be cooperateed with and synergistic effect, had both been embodied aldehydes and has been sterilized
The efficient sterilizing of agent, and the quick-acting of quaternary ammonium salt is combined, more preferably Disinfection Effect can be reached under lower dosage, to
Reduction frequency of use, the disinfectant products of high-efficiency broad spectrum can be reached.
(3), the preparation process of this product is simple, is easy to control, with short production cycle, and production cost is low, is suitble to industry
Metaplasia is produced.
Specific implementation mode
In order to make the goal of the invention, technical solution and advantage of application be more clearly understood, With reference to embodiment
The present invention is described in further detail, but the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following implementations
Example, the every other embodiment that those of ordinary skill in the art are obtained without creative efforts belong to
The scope of protection of the invention.
Embodiment 1：
A kind of compound disinfecting fungicide, includes the raw material of following mass percentage：
Water adds to 100%.
Raw material is weighed in proportion, then by raw material glutaraldehyde, alkyl dimethyl ethylbenzyl ammonium chloride (C12:C14=68:
32), zephiran (C12:C14:C16=40:50:10), solvent is added in reaction kettle, fully adds after dissolving
Enter surfactant stirring half an hour, continues to stir half an hour after after adding water to supply up to product.
Alkyl dimethyl ethylbenzyl ammonium chloride (C12：C14=68:32) dodecyl dimethyl ethylbenzyl chloride is indicated
Change the mass percent that ammonium accounts for alkyl dimethyl ethylbenzyl ammonium chloride：Dodecyldimethylamine base ethylbenzylammonium chloride accounts for alkyl
The mass percent of dimethyl ethyl benzyl ammonium chloride.
Zephiran (C12:C14:C16=40:50:10) dodecyl dimethyl Benzylmagnesium chloride is indicated
Ammonium accounts for zephiran gross mass percentage composition：Myristyl benzyl dimethyl ammonium chloride accounts for alkyl dimethyl benzyl
Ammonium chloride gross mass percentage composition：Cetalkonium chloride accounts for zephiran gross mass hundred
Divide content.Examples hereinafter is same.
Embodiment 2：
A kind of compound disinfecting fungicide, includes the raw material of following mass percentage：
Water adds to 100%.
Raw material is weighed in proportion, then by raw material glyoxal, alkyl dimethyl ethylbenzyl ammonium chloride (C12:C14=68:
32), zephiran (C12:C14:C16=5:90:5), solvent is added in reaction kettle, is fully added after dissolving
Surfactant stirs half an hour, continues to stir half an hour after after adding water to supply up to product.
Alkyl dimethyl ethylbenzyl ammonium chloride (C12：C14=68:32) dodecyl dimethyl ethylbenzyl chloride is indicated
Change ammonium accounts for the mass percent of alkyl dimethyl ethylbenzyl ammonium chloride and dodecyldimethylamine base ethylbenzylammonium chloride accounts for alkane
The mass percent of base dimethyl ethyl benzyl ammonium chloride.
Zephiran (C12:C14:C16=40:50:10) dodecyl dimethyl Benzylmagnesium chloride is indicated
Ammonium accounts for zephiran gross mass percentage composition：Myristyl benzyl dimethyl ammonium chloride accounts for alkyl dimethyl benzyl
Ammonium chloride gross mass percentage composition：Cetalkonium chloride accounts for zephiran gross mass hundred
Divide content.
Embodiment 3：
A kind of compound disinfecting fungicide, includes the raw material of following mass percentage：
Water adds to 100%.
Raw material is weighed in proportion, then by raw material by glyoxal, alkyl dimethyl ethylbenzyl ammonium chloride (C12:C14:
C16=40:50:10) zephiran (C12:C14:C16=5:90:5), solvent is added in reaction kettle, fully
Surfactant is added after dissolving and stirs half an hour, continues to stir half an hour after after adding water to supply up to product.
Alkyl dimethyl ethylbenzyl ammonium chloride (C12:C14:C16=40:50:10) dodecyl dimethyl ethyl is indicated
Benzyl ammonium chloride accounts for the mass percent of alkyl dimethyl ethylbenzyl ammonium chloride：Dodecyldimethylamine base ethylbenzylammonium chloride
Account for the mass percent of alkyl dimethyl ethylbenzyl ammonium chloride：Cetyl dimethylethyl benzyl ammonium chloride accounts for alkyl-dimethyl
The mass percent of base ethylbenzylammonium chloride.
Zephiran (C12:C14:C16=5:90:5) dodecyl benzyl dimethyl ammonium chloride is indicated
Account for zephiran gross mass percentage composition：Myristyl benzyl dimethyl ammonium chloride accounts for alkyldimethylbenzylammonium
Ammonium chloride gross mass percentage composition：Cetalkonium chloride accounts for zephiran gross mass percentage
Content.
Embodiment 4:
A kind of compound disinfecting fungicide, includes the raw material of following mass percentage：
Water adds to 100%.
Raw material is weighed in proportion, then by raw material by o-phthalaldehyde, alkyl dimethyl ethylbenzyl ammonium chloride (C12:
C14:C16:C18=40:40:10:10), Alkyl dimethyl benzyl ammonium bromide (C12:C14=40:60), reaction kettle is added in solvent
In, surfactant fully is added after dissolving and stirs half an hour, continues to stir half an hour after after adding water to supply up to product.
Alkyl dimethyl ethylbenzyl ammonium chloride (C12:C14:C16:C18=40:40:10:10) dodecyl two is indicated
Metylethylbenzyl ammonium chloride accounts for the mass percent of alkyl dimethyl ethylbenzyl ammonium chloride：Dodecyldimethylamine base benzyl ethyl
Ammonium chloride accounts for the mass percent of alkyl dimethyl ethylbenzyl ammonium chloride：Cetyl dimethylethyl benzyl ammonium chloride accounts for
The mass percent of alkyl dimethyl ethylbenzyl ammonium chloride：Octadecyldimethyl ethylbenzylammonium chloride accounts for alkyl dimethyl
The mass percent of ethylbenzylammonium chloride.
Zephiran (C12:C14=40:60) indicate that dodecyl benzyl dimethyl ammonium chloride accounts for alkane
Base dimethyl benzyl ammonium chloride gross mass percentage composition：Myristyl benzyl dimethyl ammonium chloride accounts for alkyldimethylbenzylammonium chlorination
Ammonium gross mass percentage composition.
Embodiment 5:
A kind of compound disinfecting fungicide, includes the raw material of following mass percentage：
Water adds to 100%.
Raw material is weighed in proportion, then by raw material by alkyl dimethyl ethylbenzyl ammonium chloride (C12:C14=62:38)、
Zephiran (C12:C14:C16:C18=50:30:17:3), solvent is added in reaction kettle, fully after dissolving
Continue to stir half an hour after after adding water to supply up to product.
Alkyl dimethyl ethylbenzyl ammonium chloride (C12:C14=62:38) dodecyl dimethyl ethylbenzyl chloride is indicated
Change the mass percent that ammonium accounts for alkyl dimethyl ethylbenzyl ammonium chloride：Dodecyldimethylamine base ethylbenzylammonium chloride accounts for alkyl
The mass percent of dimethyl ethyl benzyl ammonium chloride.
Zephiran (C12:C14:C16:C18=50:30:17:3) dodecyl dimethyl benzyl is indicated
Ammonium chloride accounts for zephiran gross mass percentage composition：Myristyl benzyl dimethyl ammonium chloride accounts for alkyl two
Methylbenzyl ammonium chloride gross mass percentage composition：It is total that cetalkonium chloride accounts for zephiran
Mass percentage：Stearyl dimethyl benzyl ammonium chloride accounts for zephiran gross mass percentage composition.
Embodiment 6:
A kind of compound disinfecting fungicide, includes the raw material of following mass percentage：
Water adds to 100%.
Raw material is weighed in proportion, then by raw material by glyoxal, alkyl dimethyl ethylbenzyl ammonium chloride (C12:C14:
C16:C18=5:60:30:5), solvent is added in reaction kettle, and emulsifier for mixing half an hour fully is added after dissolving, water is added to supply
After continue to stir half an hour after up to product.
Alkyl dimethyl ethylbenzyl ammonium chloride (C12:C14:C16:C18=5:60:30:5) dimethyl is indicated
Base ethylbenzylammonium chloride accounts for the mass percent of alkyl dimethyl ethylbenzyl ammonium chloride：Dodecyldimethylamine base Ethylbenzyl
Ammonium chloride accounts for the mass percent of alkyl dimethyl ethylbenzyl ammonium chloride：Cetyl dimethylethyl benzyl ammonium chloride accounts for alkane
The mass percent of base dimethyl ethyl benzyl ammonium chloride.
Zephiran (C12:C14:C16:C18=67:25:7:1) dodecyl dimethyl benzyl is indicated
Ammonium chloride accounts for zephiran gross mass percentage composition：Myristyl benzyl dimethyl ammonium chloride accounts for alkyl two
Methylbenzyl ammonium chloride gross mass percentage composition：It is total that cetalkonium chloride accounts for zephiran
Mass percentage：Stearyl dimethyl benzyl ammonium chloride accounts for zephiran gross mass percentage composition.
Sterilization experiment, present invention Candida albicans, Escherichia coli, golden yellow grape are carried out to above-described embodiment products obtained therefrom
Coccus, killing test the results are shown in Table 1, table 2, table 3.
One, equipment
(1) experimental strain Candida albicans, Escherichia coli, Staphylococcus aureus
(2) laboratory sample title：O-phthalaldehyde, glutaraldehyde, glyoxal, alkyl dimethyl ethylbenzyl ammonium chloride, list
Chain quaternary ammonium salt compound disinfectant and embodiment 1-6.
(3) neutralizer：The PBS solution of the 0.03mol/L of+2% Tween-80 of 0.5%Na2S2O3+0.7% lecithin.
Two, method：Test basis：《Disinfection technology standard》(version in 2002) 2.1.1.9.5 fungi killing tests
Three, inspection result
Table 1, Candida albicans sterilization experiment result
According to above-mentioned experimental data, in being tested to the Evaluation of Germicidal Efficacy of Candida albicans, embodiment 1-6 in aldehydes and
In the case that compound quaternary ammonium salt is reduced use, sterilizing power is better than aldehydes single dose, aldehydes and alkyl dimethyl ethylbenzyl chlorine respectively
Change ammonium compound, aldehydes and double-chain quaternary ammonium salt compound and compound quaternary ammonium salt is used alone, illustrates that aldehydes is mixed with compound quaternary ammonium salt product
Closing use has notable sterilizing synergistic effect.
Table 2, Escherichia coli sterilization experiment result
According to above-mentioned experimental data, in being tested to the Evaluation of Germicidal Efficacy of Escherichia coli, embodiment 1-6 is in aldehydes and again
In the case of square quaternary ammonium salt decrement use, sterilizing power is better than aldehydes single dose, aldehydes and alkyl dimethyl ethylbenzyl chlorination respectively
Ammonium compound, aldehydes and double-chain quaternary ammonium salt compound and compound quaternary ammonium salt are used alone, and illustrate aldehydes and compound quaternary ammonium salt product mix
Using there is notable sterilizing synergy.
Table 3, gold-coloured staphylococci sterilization experiment result
According to above-mentioned experimental data, in being tested to the Evaluation of Germicidal Efficacy of gold-coloured staphylococci, embodiment 1-6 is in aldehydes
In the case of being reduced use with compound quaternary ammonium salt, sterilizing power is better than aldehydes single dose, aldehydes and alkyl dimethyl ethylbenzyl respectively
Ammonium chloride compound, aldehydes and double-chain quaternary ammonium salt compound and compound quaternary ammonium salt are used alone, and illustrate aldehydes and compound quaternary ammonium salt product
It has been used in mixed way notable sterilizing synergistic effect.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement etc., should all be included in the protection scope of the present invention made by within refreshing and principle.
Claims (3)
1. a kind of compound disinfectant, it is characterised in that the compound disinfectant is used for the disinfection in livestock and poultry cultivation place, specifically by following
The raw material of mass percentage is made：Aldehydes 0.1-20%, alkyl dimethyl ethylbenzyl ammonium chloride 0.5-40%, single-stranded quaternary ammonium
Salt 0.5-40%, surplus are surfactant, organic solvent, water composition, each component ratio total 100%；The aldehydes is neighbour
Any one in phthalaldehyde, glutaraldehyde and glyoxal；The alkyl dimethyl ethylbenzyl ammonium chloride is decyl two
Metylethylbenzyl ammonium chloride, dodecyl dimethyl ethylbenzylammonium chloride, dodecyldimethylamine base ethylbenzylammonium chloride,
Arbitrary several mixture in cetyl dimethylethyl benzyl ammonium chloride and octadecyldimethyl ethylbenzylammonium chloride；
The single-stranded quaternary ammonium salt is dodecyl benzyl dimethyl ammonium chloride, myristyl benzyl dimethyl ammonium chloride, cetyl
Dimethyl benzyl ammonium chloride, stearyl dimethyl benzyl ammonium chloride, dodecyl dimethyl benzyl ammonium bromide, myristyl two
Methylbenzyl ammonium bromide, cetyl dimethyl benzyl ammonium bromide, octadecyl dimethyl benzyl ammonium bromide, dodecyl front three
Ammonium chloride, tetradecyl trimethyl ammonium chloride, hexadecyltrimethylammonium chloride, octadecyltrimethylammonium chloride, 12
Alkyl trimethyl ammonium bromide, tetradecyltrimethylammonium bromide, cetyl trimethylammonium bromide and octadecyl trimethyl bromine
Change arbitrary several mixture in ammonium；The surfactant is aliphatic acid polyethenoxy ether, nonylphenol polyoxyethylene ether, castor
Sesame oil polyoxyethylene ether, polyethylene glycol 200, polyethylene glycol 400, polyethylene glycol 400 dioleic acid ester, polyethylene glycol 400 list oleic acid
Any one or a few mixture in ester, span 40, sorbester p18, polysorbate40, polysorbate60 and Tween 80.
2. compound disinfectant according to claim 1, it is characterised in that include the raw material of following mass percentage：
Aldehydes 0.1-20%
Alkyl dimethyl ethylbenzyl ammonium chloride 0.5-40%
Single-stranded quaternary ammonium salt 0.5-40%
Surfactant 0-5%
Organic solvent 0-10%
Purified water is to full dose volume.
3. compound disinfectant according to claim 1, it is characterised in that：The organic solvent is ethyl alcohol, isopropanol, just
Any one or a few mixture in propyl alcohol, diethylene glycol (DEG) and cyclohexanol.
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| CN102067870A (en) * | 2011-01-21 | 2011-05-25 | 洛阳惠中兽药有限公司 | Composition of disinfectant and preparation method thereof |
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Denomination of invention: A compound disinfectant and its application Effective date of registration: 20231116 Granted publication date: 20180724 Pledgee: Bank of Shanghai Limited by Share Ltd. Chengdu branch Pledgor: CHENGDU KEHONGDA TECHNOLOGY Co.,Ltd. Registration number: Y2023510000250 |
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