CN102860923B - Nano-silver antibacterial liquid soap and preparation method thereof - Google Patents
Nano-silver antibacterial liquid soap and preparation method thereof Download PDFInfo
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- CN102860923B CN102860923B CN2012103523990A CN201210352399A CN102860923B CN 102860923 B CN102860923 B CN 102860923B CN 2012103523990 A CN2012103523990 A CN 2012103523990A CN 201210352399 A CN201210352399 A CN 201210352399A CN 102860923 B CN102860923 B CN 102860923B
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- deionized water
- handwashing liquid
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- 239000007788 liquid Substances 0.000 title claims abstract description 65
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 62
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000000344 soap Substances 0.000 title abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 45
- 239000008367 deionised water Substances 0.000 claims abstract description 31
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 31
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 30
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims abstract description 10
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 10
- 235000019864 coconut oil Nutrition 0.000 claims abstract description 10
- 239000003240 coconut oil Substances 0.000 claims abstract description 10
- 229910052938 sodium sulfate Inorganic materials 0.000 claims abstract description 10
- 235000011152 sodium sulphate Nutrition 0.000 claims abstract description 10
- 239000004332 silver Substances 0.000 claims description 22
- 229910052709 silver Inorganic materials 0.000 claims description 22
- 239000004094 surface-active agent Substances 0.000 claims description 22
- 239000000796 flavoring agent Substances 0.000 claims description 18
- 235000013355 food flavoring agent Nutrition 0.000 claims description 18
- 239000000080 wetting agent Substances 0.000 claims description 18
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 15
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- 238000003756 stirring Methods 0.000 claims description 3
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- 230000002045 lasting effect Effects 0.000 abstract description 6
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- 239000006260 foam Substances 0.000 abstract description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 abstract 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
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- 230000001737 promoting effect Effects 0.000 abstract 1
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- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 50
- 238000012360 testing method Methods 0.000 description 22
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
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- 230000035617 depilation Effects 0.000 description 4
- 230000003389 potentiating effect Effects 0.000 description 4
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- LOTKRQAVGJMPNV-UHFFFAOYSA-N 1-fluoro-2,4-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(F)C([N+]([O-])=O)=C1 LOTKRQAVGJMPNV-UHFFFAOYSA-N 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 239000001888 Peptone Substances 0.000 description 3
- 108010080698 Peptones Proteins 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
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- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 description 2
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 208000009304 Acute Kidney Injury Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010006707 Burn oesophageal Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- VYZAHLCBVHPDDF-UHFFFAOYSA-N Dinitrochlorobenzene Chemical compound [O-][N+](=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 VYZAHLCBVHPDDF-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
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- 239000004698 Polyethylene Substances 0.000 description 1
- 208000033626 Renal failure acute Diseases 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 201000011040 acute kidney failure Diseases 0.000 description 1
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- 238000005202 decontamination Methods 0.000 description 1
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- 238000003745 diagnosis Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 230000007140 dysbiosis Effects 0.000 description 1
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- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
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- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a nano-silver antibacterial liquid soap used for the daily cleaning function, which is made from 0.0003-0.0050% of nano-silver solution, 2.0-10.0% of dodecyl polyoxyethylene ether sodium sulfate (AES), 12.0-18.0% of dodecyl sodium sulfonate (LAS), 8% of coconut oil alkyl diethanolamide (6501), 1-3% of glycerol, 1% of pearling agent, 0.6% of essence, 0.01% of apple green and deionized water. The nano-silver antibacterial liquid soap is capable of effectively inhibiting staphylococcus aureus, escherichia coli and Candida albicans, can mildly remove dirt, and is rich in foam and easy to wash; and the nano-silver antibacterial liquid soap has the anti-bacteria ingredient of nano-silver, thus having the characteristics of being broad-spectrum in antibacterial effect and sterilization, high in the effect of sterilization, strong in permeability and lasting in antibacterial effect, promoting healing, etc.
Description
Technical field
The present invention relates to a kind of daily cleaning articles for use, be specifically related to a kind of nano silver antibacterial handwashing liquid with daily cleaning function and preparation method thereof.
Background technology
Since ancient times, silver just is used to accelerating wound healing, treatment is infected, purified waste water and preserve beverage, uses the silverware storing food, can prevent bacterial growth, applies but the unstability of silver ion in solution limited it.Nanometer silver is to take nanotechnology as the novel antibacterial product that foundation development forms, and has more stable physicochemical characteristics than Ag+, has very excellent characteristic at aspects such as electricity, optics and catalysis.Due to quantum effect, small-size effect with have great specific surface area, thereby has an incomparable antibacterial effect of traditional inorganic antiseptic, the potent disinfecting and sterilizing functions that silver is had has had qualitative leap especially, and safe, effect is lasting, is a kind of long-lasting and antibacterial weatherability of having.
Nano silver particles has following characteristics as natural antibacterial agent of new generation: broad-spectrum antiseptic sterilization and without any drug resistance; Potent sterilization, can kill multiple harmful pathogenic bacteria in several minutes; Permeability is strong, can infiltrate rapidly subcutaneous sterilization by pore, and common bacteria, obstinate antibacterial, fastbacteria and fungus-caused infection are had to good bactericidal action; Promote healing, improve the microcirculation of wound surrounding tissue, effectively activate and promote histiocytic growth, the healing of accelerated in wounds, reduce the generation of cicatrix; Antibiotic lasting, nano-Ag particles adopts patented technology production, and layer protecting film is arranged outward, and release that can be gradually in human body, so antibacterial effect is lasting.
The generation root of human diseases contacts antibacterial in hand, so hand disinfection is clean most important, is the effective measures of preventing spread of disease.Duty wash one's hands be control transmission of disease and protect from infection the most effectively, the method for simple possible, to the disease of transmission with through the disease of respiratory infectious, good preventive effect is arranged.And massive epidemiology investigation confirmation, hands is the important channel of hospital infection.Medical personnel's germ contamination on nursing, diagnosis and treatment activity defensive position is serious, hospital infection can directly or indirectly be propagated by medical personnel's hands, and this approach has more danger than air borne, cause spread of germs and cause the infected to account for 30 % of rate of hospital acquired infection.
And the antipathogenic composition in traditional handwashing liquid is mainly parachlorometaxylenol (PCMX), the chlorine-containing disinfecting product all has certain toxic action, the animal toxicity experimental result shows: after it enters body by gastrointestinal, can cause esophagus and gastrointestinal mucosa necrocytosis, come off, occur that esophagus burns, gastrointestinal tract mucous coming off and toxic enteritis etc.Also cause simultaneously body intestine dysbacteriosis to occur, cause acute respiratory failure, acute renal failure, and the hemopoietic system of damage body.
Therefore, for solving the problems of the technologies described above, the necessary a kind of nano silver antibacterial handwashing liquid and preparation method thereof that provides, to overcome the described defect of traditional handwashing liquid.
Summary of the invention
For addressing the above problem, the object of the present invention is to provide a kind of nano silver antibacterial handwashing liquid that broad-spectrum antiseptic sterilization, potent sterilization, permeability are strong, promote healing, the antibiotic characteristics such as lasting that has.
Another object of the present invention is to provide a kind of preparation method of nano silver antibacterial handwashing liquid.
For realizing above-mentioned the first purpose, the technical scheme that the present invention takes is: a kind of nano silver antibacterial handwashing liquid, it be take deionized water and is carrier, nanometer silver, surfactant, wetting agent, toner and flavoring agent is dissolved in to the nano material handwashing liquid of making in deionized water.
Nano silver antibacterial handwashing liquid of the present invention is further: the percentage by weight of described nanometer silver, surfactant, wetting agent, toner, flavoring agent and deionized water is respectively: nanometer silver: 0.0003%～0.0050%; Surfactant: alkylpolyoxyethylene sodium sulfate (AES) 2.0%～10.0%, dodecyl sodium sulfate (LAS) 12.0%～18.0% and coconut oil alkyl diethanolamide (6501) 8%; Wetting agent: glycerol 1%～3%; Toner: pearling agent 1%, apple green 0.01%; Flavoring agent: essence 0.6%; Surplus is deionized water.
Nano silver antibacterial handwashing liquid of the present invention is further: described surfactant is selected non-ionic surface active agent and anion surfactant.
For realizing above-mentioned the second purpose, the technical scheme that the present invention takes is: a kind of preparation method of nano silver antibacterial handwashing liquid, it comprises following processing step: (A) take alkylpolyoxyethylene sodium sulfate (AES), dodecyl sodium sulfate (LAS), add deionized water dissolving, obtain solution 1., standby; (B) coconut oil alkyl diethanolamide (6501), pearling agent are joined in glycerol, obtain solution 2., standby; (C) after 2. 1. solution stirred with solution, add nano-silver water solution, essence and apple green, stir, regulate pH value with NaOH, add deionized water to enough, finally make the nano silver antibacterial handwashing liquid.
Compared with prior art, the present invention has following beneficial effect: nano silver antibacterial handwashing liquid of the present invention can effectively suppress staphylococcus aureus, escherichia coli and Candida albicans, and gentle decontamination, foam is abundant, easily rinse, antipathogenic composition in handwashing liquid is nanometer silver, have broad-spectrum antiseptic sterilization, potent sterilization, permeability strong, promote healing, the antibiotic characteristics such as lasting.
The specific embodiment
Below by specific embodiment, nano silver antibacterial handwashing liquid of the present invention is further described, but not as limitation of the present invention.
Embodiment 1:
Nano silver antibacterial handwashing liquid of the present invention, it be take deionized water and is carrier, and nanometer silver, surfactant, wetting agent, toner and flavoring agent are dissolved in deionized water and make.Wherein, the percentage by weight of described nanometer silver, surfactant, wetting agent, toner, flavoring agent and deionized water is respectively:
Nanometer silver: 0.0003%;
Surfactant: alkylpolyoxyethylene sodium sulfate (AES) 2.0%, dodecyl sodium sulfate (LAS) 18.0% and coconut oil alkyl diethanolamide (6501) 8%;
Wetting agent: glycerol 1%;
Toner: pearling agent 1%, apple green 0.01%;
Flavoring agent: essence 0.6%;
Surplus is deionized water.
Embodiment 2:
Nano silver antibacterial handwashing liquid of the present invention, it be take deionized water and is carrier, and nanometer silver, surfactant, wetting agent, toner and flavoring agent are dissolved in deionized water and make.Wherein, the percentage by weight of described nanometer silver, surfactant, wetting agent, toner, flavoring agent and deionized water is respectively:
Nanometer silver: 0.0020%;
Surfactant: alkylpolyoxyethylene sodium sulfate (AES) 8.0%, dodecyl sodium sulfate (LAS) 12.0% and coconut oil alkyl diethanolamide (6501) 8%;
Wetting agent: glycerol 2%;
Toner: pearling agent 1%, apple green 0.01%;
Flavoring agent: essence 0.6%;
Surplus is deionized water.
Implementation column 3:
Nano silver antibacterial handwashing liquid of the present invention, it be take deionized water and is carrier, and nanometer silver, surfactant, wetting agent, toner and flavoring agent are dissolved in deionized water and make.Wherein, the percentage by weight of described nanometer silver, surfactant, wetting agent, toner, flavoring agent and deionized water is respectively:
Nanometer silver: 0.0030%;
Surfactant: alkylpolyoxyethylene sodium sulfate (AES) 10.0%, dodecyl sodium sulfate (LAS) 12.0% and coconut oil alkyl diethanolamide (6501) 8%;
Wetting agent: glycerol 2%;
Toner: pearling agent 1%, apple green 0.01%;
Flavoring agent: essence 0.6%;
Surplus is deionized water.
Implementation column 4:
Nano silver antibacterial handwashing liquid of the present invention, it be take deionized water and is carrier, and nanometer silver, surfactant, wetting agent, toner and flavoring agent are dissolved in deionized water and make.Wherein, the percentage by weight of described nanometer silver, surfactant, wetting agent, toner, flavoring agent and deionized water is respectively:
Nanometer silver: 0.0050%;
Surfactant: alkylpolyoxyethylene sodium sulfate (AES) 10.0%, dodecyl sodium sulfate (LAS) 15.0% and coconut oil alkyl diethanolamide (6501) 8%;
Wetting agent: glycerol 1%;
Toner: pearling agent 1%, apple green 0.01%;
Flavoring agent: essence 0.6%;
Surplus is deionized water.
Nano silver antibacterial handwashing liquid of the present invention can be prepared as follows, and it comprises following processing step:
(A) take alkylpolyoxyethylene sodium sulfate (AES), dodecyl sodium sulfate (LAS), add deionized water dissolving, obtains solution 1., standby;
(B) coconut oil alkyl diethanolamide (6501), pearling agent are joined in glycerol, obtain solution 2., standby;
(C) after 2. 1. solution stirred with solution, add nano-silver water solution, essence and apple green, stir, regulate pH value with NaOH, add deionized water to enough, finally make the nano silver antibacterial handwashing liquid.
For further verifying bacteriostasis and sterilization effect of the present invention, the inventor has carried out kill pathogenic fungus exam ine for above-mentioned nano silver antibacterial handwashing liquid.
Experiment material:
1. experimental strain:
Staphylococcus aureus ATCC 6538, escherichia coli 44148
Candida albicans ATCC10231
2. culture medium raw material:
Nutrient broth: lot number 000124, biochemical reagents, Beijing bispin microbiological culture media products factory
Nutrient agar: lot number 1001066, Beijing Luqiao Technology Co., Ltd.
Anhydrous glucose: lot number 990201, analytical pure, Tianjin Chemical Reagents Factory No.1
Peptone: lot number 20000215, biochemical reagents, Beijing bispin microbiological culture media products factory
Agar: Biotechnology Grad From Japan
Attached: the preparation of culture medium
(1) nutrient broth medium:
The 18g nutrient broth is dissolved in the 1000ml distilled water, heating for dissolving, and autoclaving, standby.
(2) nutrient agar:
The 33g Nutrient agar is dissolved in the 1000ml distilled water, heating for dissolving, and autoclaving, standby.
(3) Sharpe fluid medium:
Peptone 10g, anhydrous glucose 40g, be dissolved in the 1000ml distilled water, heating for dissolving, autoclaving, standby.
(4) husky fort agar culture medium:
Peptone 10g, anhydrous glucose 40g, be dissolved in the 300ml distilled water; 20g agar is dissolved in the 700ml distilled water; By the two mixing, autoclaving, standby.
3. sodium hydrogen phosphate: analytical pure, Tianjin Fengchuan Chemical Reagent Science & Technology Co., Ltd.
Potassium dihydrogen phosphate: analytical pure, the upright chemical reagent work of the Tianjin North Star
Sodium thiosulfate: analytical pure, Beijing chemical reagents corporation
Tween 80: Hunan Ning Kang pharmaceutical Co. Ltd
Lecithin: biochemical reagents, Tianjin recovery fine chemistry industry institute
4. inoculating loop, suction pipe, test tube, stopwatch, 37 ℃ of incubators etc.
Experimental technique and result
1. bacteriostasis rate test
Test organisms 24h slant culture is washed down with PBS, and alkene is interpreted into the bacteria suspension that concentration is 3 * 106 cfu/ml.Taking liquid 5ml 1 pipe; Get above-mentioned bacteria suspension 0.1ml and be placed in drug liquid tube, start timing, effect 2,5,10,20min, pipette respectively solution 0.5ml input in drug liquid tube with aseptic straw and contain 4.5ml nertralizer 2 in vitro, fully mixes, act on 10 minutes, suitably alkene is released, and draws respectively 1ml and is placed in two plates, pours into cool nutrient agar (for coliform, golden Portugal bacterium) or sabouraud's agar (for reading in vain bacterium) 20ml to 60 ℃, rotate plate, make it full and uniform, it is dull and stereotyped that agar solidifies rear upset, cultivates 48h for 37 ℃.Do the viable bacteria colony counting.With distilled water, replace medicinal liquid to do identical processing as the positive control pipe.
Calculate bacteriostasis rate:
X=(A mono-B)/A
X: bacteriostasis rate, %
A: the average clump count of positive control solution
B: tested medicinal liquid sample average clump count
Experimental result is as follows:
Table 1 nano silver antibacterial handwashing liquid (15 μ g/ml) bacteriostasis rate experimental result
| 2min | 5min | 10min | 20min | |
| Escherichia coli | 100% | 100% | 100% | 100% |
| Staphylococcus aureus | 100% | 100% | 100% | 100% |
| Candida albicans | 100% | 100% | 100% | 100% |
Nano silver antibacterial handwashing liquid 15 μ g/ml are to escherichia coli, staphylococcus aureus, and Candida albicans 2min, 5min, 10min, the 20min bacteriostasis rate is 100%.
2. sterilizing rate test
Test organisms 24h slant culture is washed down with PBS, and alkene is interpreted into the bacteria suspension that concentration is 3 * 108cfu/ml.Taking liquid 4ml 1 pipe adds above-mentioned bacteria suspension 0.5ml; Start timing, effect 2,5,10,20min, pipette respectively medicinal liquid 0.5ml input with aseptic straw and contain 4.5ml nertralizer 2 in vitro, fully mix, act on 10 minutes, suitably alkene is released, draw respectively 1ml and be placed in two plates, with cool nutrient agar (for coliform, golden Portugal bacterium) or sabouraud's agar (for reading in vain bacterium) 20ml to 60 ℃, pour into, rotate plate, make it full and uniform, it is dull and stereotyped that agar solidifies rear upset, cultivates 48h for 37 ℃.Do the viable bacteria colony counting.With distilled water, replace medicinal liquid to do same treatment, as positive control.Calculate sterilizing rate:
X=(A mono-B)/A
X: sterilizing rate, %;
A: the average clump count of control sample; B: tested sample average clump count
Table 2 nano silver antibacterial handwashing liquid (15 μ g/ml) sterilizing rate experimental result
 |
2min | 5min | 10min | 20min |
| Escherichia coli | 33.8% | 41.5% | 92.4% | 100% |
| Staphylococcus aureus | 99.5% | 100% | 100% | 100% |
| Candida albicans | 90.8% | 95.85% | 98.05% | 100% |
Visible by above result, nano silver antibacterial handwashing liquid 15 μ g/ml are to escherichia coli, staphylococcus aureus, and the sterilizing rate after Candida albicans 2min all is greater than 90%.
For verifying further whether the present invention can produce anaphylaxis, and the inventor has carried out hypersensitive test for above-mentioned nano silver antibacterial handwashing liquid.
Experiment material:
Healthy albino guinea-pig: skin is intact, and 48, male and female half and half, body weight 200-300g, be purchased from Mountain Western Medicine S University's Experimental Animal Center (animal number: SCXK (Shanxi) 2009-0001);
The nano silver antibacterial handwashing liquid: Zhejiang three standing grain nanosecond science and technology company limiteies provide;
DNFB: Tianjin recovery fine chemistry industry institute.
Method and step:
Cavia porcellus is divided into to 3 groups at random, 16 every group, is respectively test group, negative control group and positive controls.In front 24 h of test, by guinea pig back both sides unhairing (3 cm * 3 cm).To the test group Cavia porcellus, give tested material nano silver antibacterial handwashing liquid and induce and excite processing.Positive controls gives positive sensitizer DNFB and induces and excite processing.Negative control group is only given the nano silver antibacterial handwashing liquid and is excited processing.
3.1 sensitization contact (Induction exposure) is got nano silver antibacterial handwashing liquid 0.5ml, is coated in depilation district, test group guinea pig back left side.Every Cavia porcellus sub-cage rearing, after 6h with the warm water cleaning tested material.7th, 14 days, in kind repeat respectively 1 time.Positive controls is with 0.1% DNFB 0.5ml, and experimental technique is the same.
3.2 excite contact time to give 14 d after tested medicine sensitization, test group and negative control group all are coated in depilation district, guinea pig back right side by tested material nano silver antibacterial handwashing liquid 0.5ml, positive controls is by 0.1% 2,4-dinitrochlorobenzene 0.5ml is coated in depilation district, guinea pig back right side, after 6 h with the warm water cleaning tested material, after 24h and 48h, observe dermoreaction, mark by table 1 pair dermoreaction.
Observe and evaluation of result:
According to table 1 " skin allergy standards of grading " scoring, calculate the reaction scoring meansigma methods of respectively organizing Cavia porcellus.The difference of reacting with the negative control group guinea pig skin according to test group, the skin allergy effect of judgement tested material nano silver antibacterial handwashing liquid, in anaphylactoid animal ratio calculating sensitization rate occurring, according to the intensity of table 2 " sensitization strength grading standard " judgement tested material nano silver antibacterial handwashing liquid sensitivity response.
Sensitization rate computing formula is: sensitization rate/%=[the animal number of cases of skin allergy positive (no matter degree weight)/this group animal subject sum] * 100%
Table 1 sensitization of skin reaction standards of grading
| Erythema forms | Scoring | Edema forms | Scoring |
| Without erythema | 0 | Without edema | 0 |
| Slight erythema | 1 | Mild edema | 1 |
| Moderate erythema | 2 | Intermediate edema | 2 |
| Serious erythema | 3 | Serious edema | 3 |
| Edematous erythema | 4 | ? | ? |
Table 2 sensitization strength grading standard
| Sensitization rate (%) | Sensitization intensity |
| 0～8 | Extremely slight |
| 9～28 | Slightly |
| 29～64 | Moderate |
| 65～80 | Intensity |
| 81～100 | Pole strength |
The sensitization of skin experimental result of table 3 nano silver antibacterial handwashing liquid
Brief summary and discussion
The sensitization of skin experimental result of nano silver antibacterial handwashing liquid can find out, the nano silver antibacterial handwashing liquid has extremely slight sensitization.
For further whether checking the present invention is irritant to skin, the inventor has carried out irritation test for above-mentioned nano silver antibacterial handwashing liquid.
Experiment material:
12 of healthy rabbits, body weight 2 scholar 0.2kg, male and female half and half, be purchased from Mountain Western Medicine S University's zoopery center; Nano silver antibacterial handwashing liquid: provided by Zhejiang three standing grain nanosecond science and technology company limiteies.
Experimental technique:
1. single-dose irritation testGet 8 of healthy rabbits, be divided at random 2 groups, 4 every group.Getting wherein 1 group is the intact skin test group, tests front 24 h, by rabbit spinal column both sides unhairing (3 cm * 3 cm), respectively as tested material district and negative control area.Before giving tested material nano silver antibacterial handwashing liquid, should check whether skin of unhairing has mechanical damage, diminishing the wounded should not test.Tested material nano silver antibacterial handwashing liquid 0.5 ml is smeared in tested material next day district, covers with double gauze (2. 5 cm * 2. 5 cm) and polyethylene film, is fixed with nonirritant adhesive plaster and binder; Negative control area is as blank.Get other 1 group of rabbit, before being coated with tested material nano silver antibacterial handwashing liquid, on the skin of unhairing of 2.5cm * 2.5cm,, sterilization clean with 75% ethanol exposes skin, after the ethanol volatilization, the damaged wound of standardized " well " shape in dermatotome with sterilizing blade or injection needle, as the damaged skin test group, the drug treating mode is with the intact skin group.After 4 h, water washes away all rabbit depilations district residue, respectively at 1h, 24h and 48h after the removal tested material, observe the local skin reaction, by table 1, carry out the irritant reaction scoring, and press the rank of table 2 evaluation nano silver antibacterial handwashing liquid to the animal skin stimulus intensity.
. multiple dosing intact skin irritation test4 of healthy rabbits, grouping, unhairing, medication are identical with the single-dose irritation test.4h after smearing, water cleans, and removes residue.Smear every day once, smear continuously 14d.24h observed result after at every turn smearing, press table 1 scoring, and press the rank that table 2 is judged skin irritation intensity.
Table 1 skin irritation reaction standards of grading
| Erythema forms | The reaction scoring | Edema forms | The reaction scoring |
| Nothing | 0 | Nothing | 0 |
| Visible reluctantly | 1 | Visible reluctantly | 1 |
| Obviously | 2 | Cutaneous protuberance, profile is clear | 2 |
| Seriously | 3 | The about 1mm of edema protuberance | 3 |
| The aubergine erythema, and eschar is arranged | 4 | The edema protuberance surpasses 1mm | 4 |
Table 2 skin irritation intensity evaluation standard
| Skin irritation index | The stimulus intensity rank |
| 0~<0.5 | Nonirritant |
| 0.5~<2.0 | Subexcite |
| 2.0~<6.0 | Medium zest |
| 6.0~8.0 | Strong and stimulating |
Experimental result
Visible by table 3 result: after nano silver antibacterial handwashing liquid rabbit single-dose, intact skin and damaged skin are showed no local erythema and edema forms, and relatively without significant difference, is showed no zest with the blank group.Multiple dosing the results are shown in Table 4, and nano silver antibacterial handwashing liquid successive administration 14d has no local erythema and edema and forms, and with the blank group, compares without significant difference, all nonirritant.
Table 3 nano silver antibacterial handwashing liquid single-dose skin irritation test result
Table 4 nano silver antibacterial handwashing liquid multiple dosing intact skin stimulation test result
Brief summary and discussion
Visible by above result, the nano silver antibacterial handwashing liquid is without skin irritation.
The above specific embodiment is only the preferred embodiment of this creation, not in order to limit this creation, any modification of making within all spirit in this creation and principle, is equal to replacement, improvement etc., within all should being included in the protection domain of this creation.
Claims (2)
1. nano silver antibacterial handwashing liquid is characterized in that: it be take deionized water and is carrier, nanometer silver, surfactant, wetting agent, toner and flavoring agent is dissolved in to the nano material handwashing liquid of making in deionized water; Wherein, the percentage by weight of described nanometer silver, surfactant, wetting agent, toner, flavoring agent and deionized water is respectively:
Nanometer silver: 0.0003%～0.0050%;
Surfactant: alkylpolyoxyethylene sodium sulfate (AES) 2.0%～10.0%, dodecyl sodium sulfate (LAS) 12.0%～18.0% and coconut oil alkyl diethanolamide (6501) 8%;
Wetting agent: glycerol 1%～3%;
Toner: pearling agent 1%, apple green 0.01%;
Flavoring agent: essence 0.6%;
Surplus is deionized water;
Described surfactant is selected non-ionic surface active agent and anion surfactant.
2. the preparation method of a nano silver antibacterial handwashing liquid as claimed in claim 1 is characterized in that: comprise following processing step:
(A) take alkylpolyoxyethylene sodium sulfate (AES), dodecyl sodium sulfate (LAS), add deionized water dissolving, obtains solution 1., standby;
(B) coconut oil alkyl diethanolamide (6501), pearling agent are joined in glycerol, obtain solution 2., standby;
(C) after 2. 1. solution stirred with solution, add nano-silver water solution, essence and apple green, stir, regulate pH value with NaOH, add deionized water to enough, finally make the nano silver antibacterial handwashing liquid.
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