CN109157444A - A kind of mild hand cleanser of long-acting bacteriostatic and preparation method thereof - Google Patents
A kind of mild hand cleanser of long-acting bacteriostatic and preparation method thereof Download PDFInfo
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- CN109157444A CN109157444A CN201810880583.XA CN201810880583A CN109157444A CN 109157444 A CN109157444 A CN 109157444A CN 201810880583 A CN201810880583 A CN 201810880583A CN 109157444 A CN109157444 A CN 109157444A
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- hand cleanser
- sodium
- acting bacteriostatic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Abstract
The present invention proposes a kind of mild hand cleanser of long-acting bacteriostatic, it is composed of the following components: four sodium of glutamic acid diacetic acid of 0.5-1%, the sodium sulfate of polyethenoxy ether of fatty alcohol of 8-11%, the Cocoamidopropyl betaine of 3.5-5.5%, the cocoanut fatty acid diethanolamide of 2-3%, the alcohol ether glucoside of 4-5.5%, the glycerine of 1.5-2.2%, the C12-C13 alkanol lactate of 0.3-0.6%, the silver ion of 0.1-0.15%, the wormwood extract of 0.05-0.1%, the preservative of 0.05-0.15%, the thickener of 0.5-1.5%, 0.1-0.3% essence, balance deionized water.The mild hand cleanser of long-acting bacteriostatic proposed by the present invention does not stimulate mildly and antibacterial persistently effective.The present invention also proposes the preparation method of the mild hand cleanser of long-acting bacteriostatic, specific to add step to increase the stability of active principle.
Description
Technical field
The present invention relates to mild hand cleanser of a kind of long-acting bacteriostatic and preparation method thereof.
Background technique
Hand cleanser be it is a kind of cleaning hand based on skin care cleaning solution, used in life extensively.The addition of some hand cleanser
Antipathogenic composition can play the role of disinfection, sterilization, but those ingredients may stimulate hand skin to be easy allergy to skin
People be not suitable for use.Part hand cleanser uses natural antipathogenic composition, and natural antipathogenic composition is mostly extracting solution essential oil, few
The volatile failure of the essential oil of amount, the amount for increasing essential oil also can cause to stimulate to skin.
Summary of the invention
To solve the above problems, the present invention proposes a kind of mild hand cleanser of long-acting bacteriostatic, do not stimulate mildly and antibacterial lasting
Effectively.The present invention also proposes the preparation method of the mild hand cleanser of long-acting bacteriostatic described in one kind, and specific step of adding is to increase
The stability of active principle.
The present invention proposes a kind of mild hand cleanser of long-acting bacteriostatic, by mass percentage, composed of the following components: 0.5-1%
Four sodium of glutamic acid diacetic acid, the sodium sulfate of polyethenoxy ether of fatty alcohol of 8-11%, 3.5-5.5% cocamidopropyl propyl amide beet
Alkali, the cocoanut fatty acid diethanolamide of 2-3%, the alcohol ether glucoside of 4-5.5%, the glycerine of 1.5-2.2%, 0.3-
0.6% C12-C13 alkanol lactate, the silver ion of 0.1%-0.15%, the wormwood extract of 0.05-0.1%, 0.05-
0.15% preservative, the thickener of 0.5-1.5%, 0.1-0.3% essence, balance deionized water, the sum of each component is hundred
/ hundred.
Further, the mild hand cleanser of the long-acting bacteriostatic, it is by mass percentage, composed of the following components: 1% paddy
Four sodium of propylhomoserin oxalic acid, 9% sodium sulfate of polyethenoxy ether of fatty alcohol, 5% Cocoamidopropyl betaine, 2% coconut
Fatty acid oil diglycollic amide, 5% alcohol ether glucoside, 2% glycerine, 0.5% C12-C13 alkanol lactate, 0.1%
Silver ion, 0.05% wormwood extract, 0.1% preservative, 1% thickener, 0.1% essence, surplus deionization
Water, the sum of each component are absolutely.
Further, the silver ion is nano-silver ionic.
Further, the thickener is sodium chloride.
The present invention also proposes a kind of preparation method of above-mentioned mild hand cleanser of long-acting bacteriostatic, comprising the following steps:
Step 1: injecting 40~50% deionized water in a mixing bowl, four sodium of glutamic acid diacetic acid is added, is dispersed with stirring
To solution clear;
Step 2: sodium sulfate of polyethenoxy ether of fatty alcohol, Cocoamidopropyl betaine, coco-nut oil fatty acid diethyl is added
Alkylolamides and alcohol ether glucoside, stir evenly;
Step 3: silver ion and wormwood extract stirring is added in C12-C13 alkanol lactate after being dissolved with glycerol dispersion
Uniformly, it is added in a mixing bowl later;
Step 4: preservative, thickener and essence and balance deionized water is added, it is uniformly mixing to obtain finished product.
Beneficial effects of the present invention:
The present invention is by anion table sodium sulfate of polyethenoxy ether of fatty alcohol living, with amphoteric ion table cocamidopropyl propyl amide living
Glycine betaine compounds to obtain in certain proportion mild with nonionic table cocoanut fatty acid diethanolamide living and alcohol ether glucoside
Hand cleanser matrix, foaming abundancy and easily rinse.The present invention is added to C12-C13 alkanol lactate, can reduce irritation, and
Skin moisturizing is not dried after washing one's hands.The present invention compounds addition with wormwood extract by silver ion, and fungistatic effect is significant;And silver from
Son and wormwood extract increase bacteriostatic agent in the stop of skin by being used in compounding with C12-C13 alkanol lactate and glycerine
Time achievees the effect that long-acting bacteriostatic.
Specific embodiment
As follows in conjunction with specific embodiments, application scheme is further described:
Embodiment 1
A kind of mild hand cleanser of long-acting bacteriostatic, it is by mass percentage, composed of the following components: 1% glutamic acid diacetic acid
Four sodium, 9% sodium sulfate of polyethenoxy ether of fatty alcohol, 5% Cocoamidopropyl betaine, 2% coco-nut oil fatty acid two
Glycollic amide, 5% alcohol ether glucoside, 2% glycerine, 0.5% C12-C13 alkanol lactate, 0.1% silver ion,
0.05% wormwood extract, 0.1% preservative, 1% thickener, 0.1% essence, balance deionized water, each component
The sum of for absolutely.
The silver ion is nano-silver ionic.The thickener is sodium chloride.
A kind of preparation method of the mild hand cleanser of above-mentioned long-acting bacteriostatic, comprising the following steps:
Step 1: injecting 40~50% deionized water in a mixing bowl, four sodium of glutamic acid diacetic acid is added, is dispersed with stirring
To solution clear;
Step 2: sodium sulfate of polyethenoxy ether of fatty alcohol, Cocoamidopropyl betaine, coco-nut oil fatty acid diethyl is added
Alkylolamides and alcohol ether glucoside, stir evenly;
Step 3: silver ion and wormwood extract stirring is added in C12-C13 alkanol lactate after being dissolved with glycerol dispersion
Uniformly, it is added in a mixing bowl later;
Step 4: preservative, thickener and essence and balance deionized water is added, it is uniformly mixing to obtain finished product.
Finished product obtained is tested:
One, an intact skin irritation/corrosivity
It is tested according to the test method of " disinfection technology standard " version second part 2.3.3 in 2002
1, test procedure
The hair of experimental animal (new zealand rabbit) spinal cord two sides is rejected, samples 0.5mL as tested in the finished product of embodiment 1
Object is applied on the skin of side, is covered with two layers of gauze and one layer of glassine paper or the like, then added with non-stimulated adhesive plaster and bandage
With fixation, other side skin is as own control.Using blocking test, the application time is 4h.After experiment, removed with water residual
Stay tested material.
2, evaluation of result
1, the 24 and 48h after removing tested material observes recipient site dermoreaction as a result, by skin wound repair respectively
Grade form carries out dermoreaction scoring.According to each point of observation top mean value of 1,24 and 48h, by skin irritatin strength grading
Standard list deciding skin irritatin intensity.The determination of observing time should be enough to observe the full mistake of reversible or irreversible stimulation
Journey is usually no more than 14d.
3, test result
4, conclusion
Under this reality time experimental condition, tested material is to intact skin irritation/corrosion test result of new zealand rabbit
It is non-stimulated.
Two, antibacterial test:
The finished product of embodiment 1 is sampled, according to daily chemical products antibacterial-fungistatic effect evaluation method:
QB/T2738-2012 is tested, as a result as follows:
To sum up, long-acting bacteriostatic of the invention mild hand cleanser does not stimulate skin mildly while fungistatic effect is significant.
It is that above-mentioned preferred embodiment should be regarded as application scheme embodiment for example, all with application scheme thunder
Same, approximate or technology deduction, replacement, improvement for making based on this etc., are regarded as the protection scope of this patent.
Claims (5)
1. a kind of mild hand cleanser of long-acting bacteriostatic, which is characterized in that by mass percentage, composed of the following components: 0.5-1%'s
Four sodium of glutamic acid diacetic acid, the sodium sulfate of polyethenoxy ether of fatty alcohol of 8-11%, 3.5-5.5% cocamidopropyl propyl amide beet
Alkali, the cocoanut fatty acid diethanolamide of 2-3%, the alcohol ether glucoside of 4-5.5%, the glycerine of 1.5-2.2%, 0.3-
0.6% C12-C13 alkanol lactate, the silver ion of 0.1-0.15%, the wormwood extract of 0.05-0.1%, 0.05-
0.15% preservative, the thickener of 0.5-1.5%, 0.1-0.3% essence, balance deionized water, the sum of each component is hundred
/ hundred.
2. the mild hand cleanser of long-acting bacteriostatic according to claim 1, which is characterized in that by mass percentage, by with the following group
Be grouped as: 1% four sodium of glutamic acid diacetic acid, 9% sodium sulfate of polyethenoxy ether of fatty alcohol, 5% cocamidopropyl propyl amide sweet tea
Dish alkali, 2% cocoanut fatty acid diethanolamide, 5% alcohol ether glucoside, 2% glycerine, 0.5% C12-C13 alkane
Alcohol lactate, 0.1% silver ion, 0.05% wormwood extract, 0.1% preservative, 1% thickener, 0.1% perfume (or spice)
Essence, balance deionized water, the sum of each component are absolutely.
3. the mild hand cleanser of long-acting bacteriostatic according to claim 1 or 2, which is characterized in that the silver ion is nanometer
Silver ion.
4. the mild hand cleanser of long-acting bacteriostatic according to claim 1 or 2, which is characterized in that the thickener is chlorination
Sodium.
5. a kind of preparation method of the mild hand cleanser of described in any item long-acting bacteriostatics of claim 1-4, which is characterized in that including
Following steps:
Step 1: injecting 40~50% deionized water in a mixing bowl, four sodium of glutamic acid diacetic acid is added, is dispersed with stirring to molten
Liquid clear;
Step 2: sodium sulfate of polyethenoxy ether of fatty alcohol, Cocoamidopropyl betaine, coco-nut oil fatty acid diethanol acyl is added
Amine and alcohol ether glucoside, stir evenly;
Step 3: silver ion is added after being dissolved with glycerol dispersion for C12-C13 alkanol lactate and wormwood extract stirs evenly,
It is added in a mixing bowl later;
Step 4: preservative, thickener and essence and balance deionized water is added, it is uniformly mixing to obtain finished product.
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CN201810880583.XA CN109157444A (en) | 2018-08-04 | 2018-08-04 | A kind of mild hand cleanser of long-acting bacteriostatic and preparation method thereof |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109718130A (en) * | 2019-02-27 | 2019-05-07 | 林燕 | A kind of preparation method of nano silver/chitosan composite antibiotic hand cleanser |
CN111657306A (en) * | 2020-06-19 | 2020-09-15 | 广东一芙化妆品有限公司 | Herbaceous plant silver ion composition and application thereof |
CN112274462A (en) * | 2020-09-17 | 2021-01-29 | 浙江森马服饰股份有限公司 | Composite bacteriostatic agent with bacteriostatic and epidermal moisturizing effects and preparation and application thereof |
CN113332186A (en) * | 2021-05-19 | 2021-09-03 | 上海卡贸电子商务有限公司 | Foam hand sanitizer containing silver ions and preparation method thereof |
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2018
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109718130A (en) * | 2019-02-27 | 2019-05-07 | 林燕 | A kind of preparation method of nano silver/chitosan composite antibiotic hand cleanser |
CN111657306A (en) * | 2020-06-19 | 2020-09-15 | 广东一芙化妆品有限公司 | Herbaceous plant silver ion composition and application thereof |
CN112274462A (en) * | 2020-09-17 | 2021-01-29 | 浙江森马服饰股份有限公司 | Composite bacteriostatic agent with bacteriostatic and epidermal moisturizing effects and preparation and application thereof |
CN113332186A (en) * | 2021-05-19 | 2021-09-03 | 上海卡贸电子商务有限公司 | Foam hand sanitizer containing silver ions and preparation method thereof |
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