CN107412090A - A kind of long-acting bacteriostatic composition and its preparation method and application - Google Patents
A kind of long-acting bacteriostatic composition and its preparation method and application Download PDFInfo
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- CN107412090A CN107412090A CN201710280071.5A CN201710280071A CN107412090A CN 107412090 A CN107412090 A CN 107412090A CN 201710280071 A CN201710280071 A CN 201710280071A CN 107412090 A CN107412090 A CN 107412090A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0279—Porous; Hollow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Abstract
The present invention relates to a kind of long-acting bacteriostatic composition and its preparation method and application, by weight, including following component：10 50 parts of polyalcohol, 0.1 2 parts of thickener, 0.5 5 parts of preservative, 15 parts of natural plant extracts, 0.1 0.5 parts of chemical bacteriostatic agent, 10 50 parts of water, wherein, the natural plant extracts are chamomile, tealeaves and the leaf of bamboo in mass ratio 1:1:The water extract of gained mixture after 1 mixing.The bacteria inhibiting composition of the present invention is used as bacteriostatic agent using natural plant extracts, greatly reduces the usage amount of chemical bacteriostatic agent, non-stimulated to skin, safe, and fungistatic effect is long-acting lasting.
Description
Technical field
The present invention relates to a kind of long-acting bacteriostatic composition and its preparation method and application, belong to daily use chemicals technical field.
Background technology
Shown according to the data of correlation report, in the past year, it is small that Latin America there are 2175 newborn babies to be detected
Head disease or other neurotrosises disease, and these diseases be noted it is relevant with zika virus.With zika virus, H1N1,
For these viruses such as H7N9 gradually known to consumer, consumer increasingly pays close attention to the protection to bacterium in daily life.And mesh
Before the antibacterial liquid declared wash bacteriostatic agent would generally be added in product, these bacteriostatic agent some have very big toxicity, or need
Harsh preservation condition, and it is not lasting enough.
In the case of increasingly focusing on product safety and environmental protection in recent years, it is therefore necessary to develop natural plant
Bacteriostatic agent, and bacteriostatic agent is wrapped up or the processing of special process, the characteristic of slow release is made it have, while reduce skin
Excitant.
The content of the invention
Present invention deficiency existing for existing antibacterial product and its technology of preparing, there is provided a kind of long-acting bacteriostatic composition and
Its preparation method and application.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：
A kind of long-acting bacteriostatic composition, by weight, including following component：Polyalcohol 10-50 parts, thickener 0.1-2
Part, preservative 0.5-5 parts, natural plant extracts 1-5 parts, chemical bacteriostatic agent 0.1-0.5 parts, water 10-50 parts, wherein, it is described
Natural plant extracts are chamomile, tealeaves and the leaf of bamboo by weight 1:1:The water extract of the mixture of 1 mixing.
Further, the polyalcohol is one or more of mixing in glycerine, butanediol, propane diols, Macrogol 600
Thing.
Further, the thickener be carragheen, gellan gum, xanthans, hydroxypropyl methyl cellulose, Sodium Hyaluronate,
One or more of mixtures in cellulose gum.
Further, the preservative is Phenoxyethanol, soluble metyl hydroxybenzoate, nipagin A sodium, sodium benzoate, methylol
Sodium Glycinate, methylisothiazolinone, methylchloroisothiazandnone, Bis(hydroxymethyl)imidazolidinyl urea, iodine propilolic alcohol butyl ammonia
One or more of mixtures in formic acid esters, sodium sorbate.
Further, the chemical bacteriostatic agent is parachlorometaxylenol, o-phenyl phenol, BZK, salicylic acid, bigcatkin willow
One or more of mixtures in sour sodium, triclosan, triclocarban.
Each feedstock property of natural plant extracts of the present invention is as follows：
Chamomile：Mildly bitter flavor, Gan Xiang, improving eyesight, irascibility is moved back, treatment insomnia, reduce blood pressure, can invigorate, refresh oneself.Enhancing
Memory, reduce cholesterol.Expelling phlegm and arresting coughing, it can effectively alleviate bronchitis and asthma, the headache that can releive, antimigraine or flu are drawn
The courbature risen, it is helpful to neutralizing hydrochloric acid in gastric juice, calm nerves.The caused Ji Rou Acid pain of flu can be eliminated, the spirit that can calm, is relaxed
Slow mood, lifts sleep quality, can also improve the skin of allergy.Helpful sleep, moist skin, prolonged constipation can be controlled, can be disappeared
Except anxiety, eye fatigue, moistening lung, health, and can treat anxiety and it is nervous caused by indigestion, and to insomnia, neuralgia and
Cramp, enterogastritis have all been benefited, have mitigated headache.Chamomile tea can alleviate toothache when mouthwash；Adding in shampoo to be
Hair increases beautiful gloss；
The leaf of bamboo：The leaf of bamboo has the effect of clearing heat and relieving fidgetness, diuresis, is mainly used in treatment disease heat, cough with dyspnea, haematemesis, heat in the heart
Malicious wind, only quench one's thirst, press borax poison, dissolving phlegm, control it is fanatical unhappiness, apoplectic aphasia in silence, pain intermittent headache, stop palpitate with fear, pestilence be confused it is vexed, kill it is small
Worm, except diseases such as the slow spleens of heat；
Tealeaves：It is mildly bitter flavor, sweet, it is cool in nature.Energy refresh oneself, spirit of waking up, solve polydipsia, diuresis, digestion gathered food, removing toxic substances.For wind
Violate in heat, dizzy blurred vision；Hot summer weather polydipsia, or insobriety；Dormancy has been slept, the tired body of god is tired more；Oliguria with red urine, or oedema urine
It is few；Greasy dyspepsia, indigestion；Damp-heat diarrhea, dysentery.
The beneficial effect of bacteria inhibiting composition of the present invention is：Using natural plant extracts as bacteriostatic agent, greatly drop
The low usage amount of chemical bacteriostatic agent, it is non-stimulated to skin, it is safe, and fungistatic effect is long-acting persistently.
The preparation method of above-mentioned bacteria inhibiting composition is as follows：
1) sol solution of bacteria inhibiting composition is prepared
By thickener disperse polyol, water is added afterwards, opens stirring and heating, 10-60min is incubated at 50-90 DEG C,
After be cooled to 50 DEG C, add natural plant extracts, chemical bacteriostatic agent and preservative thereto, the peptization of bacteria inhibiting composition be made
Liquid；
2) nanometer sol solution is prepared
The sol solution of gained in step 1) is sprayed by high-pressure homogeneous equipment, material with the flow velocity of 1000~1500 meter per seconds
Go out, by caused void effect, knock-on effect, shearing effect, obtain uniform, fine and smooth, nano level sol solution；
3) porous nano colloid is prepared
The sol solution obtained in step 2) is placed in liquid nitrogen and freezed, be transferred to after product fully charge in refrigerator in-
Preserved in less than 18 DEG C of environment.
Further, the feed pressure control of step 2) mesohigh homogenizer is in 0.35~0.55MPa, and homogenization pressure 50~
250MPa。
The beneficial effect of preparation method of the present invention is：
Bacteriostatic activity thing is wrapped up and refined using high pressure homogenization technique in this method, may be such that bacteriostatic activity thing shape
Into nano particle, particle diameter is small, and is uniformly distributed among distinctive loose structure, after its product is added in washing product,
Have the function that improving bacteriostatic agent retains and be sustained on skin, bacteriostasis efficacy can be played with the long period, while reduce skin
Excitant.
The hand cleanser for including above-mentioned bacteria inhibiting composition is also claimed in the present invention.
Further, hand cleanser fraction meter by weight, including following component：Surfactant 5-25%, NMF
0.5-5%, thickening stabilizing agent 0.5-2.5%, appearance modifying agents 0.001-1.5%, metal ion chelation agent 0.01-0.05%,
Emollient 0.5-2.0%, essence 0.2-1.0%, long-acting bacteriostatic composition 0.2-2.0%, preservative 0.1-1%, surplus is water.
Further, the surfactant is laureth sodium sulfovinate, bay alcohol sulfuric ester ammonium, lauroyl both sexes base
Sodium acetate, Cocoamidopropyl betaine, coconut monoethanol amide, cocounut oil diglycollic amide, potassium lauroyl sarcosine, decyl Portugal
Glucosides, cocoyl glucoside, laureth sulfosuccinate disodium, oleth -10, cocamidopropyl propyl amide PG- diformazans
One or more of mixtures in ammonium chloride phosphate；
The NMF is propane diols, butanediol, polyethylene glycol 400, glycerine, sorbierite, pyrrolidone sodium carboxylate, ammonia first
One or more of mixtures in base propyl alcohol；
The thickening stabilizing agent is methyl dioleate, hydroxypropyl methyl cellulose, trehalose, sodium chloride, propylene
Sour (ester) copolymer, two (hydrogenated-tallow group) phthalic acid amides, carbomer, acrylic acid (ester) class/C10-30 alkylol acrylamides
One or more of mixtures in acid esters cross-linked polymer, guar hydroxypropyltrimonium chloride, polyquaternium -37.
The appearance modifying agents are OXYBENZONE, UVNUL MS-40, styrene/acrylic (ester) analog copolymer, pigment, second two
One or more of mixtures in alcohol distearate, ethylene glycol monostearate；The metal ion chelation agent is EDTA
One or more of mixtures in disodium, the sodium of EDTA tetra-；
The emollient is glyceryl cocoate, C12-15 alcohol lactate, castor oil-base maleic acid esters, glycerine polypropylene
The smooth sesquialter caprylate of acid esters, sorb, the dimethyl silicone polymer of polyethylene glycol -14, the caprylic/capric of polyethylene glycol -6 glyceride type,
One kind in caramel cocounut oil acid esters, the decylate of polyglycereol -3, double-dimethyl silicone polymer of polyethylene/polypropylene glycol -20/20
Or several mixture；
The preservative is Phenoxyethanol, pungent glycol, sorbic acid, dehydroactic acid, soluble metyl hydroxybenzoate, ethylparaben
Sodium, sodium benzoate, sodium hydroxy methyl glycinate, methylisothiazolinone, methylchloroisothiazandnone, imidazolidinyl urea, double (hydroxyl first
Base) imidazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, sodium sorbate, in one or more of mixtures.
Embodiment
The principle and feature of the present invention are described below in conjunction with example, the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the present invention.
Natural plant extracts used in the present invention are chamomile, tealeaves and the leaf of bamboo by weight 1:1:1 mixing mixes
The water extract of compound, extraction process are：Solid-liquid ratio 1:20,90 DEG C of Extracting temperature, extraction time 2h.
First, bacteria inhibiting composition and preparation method thereof
Embodiment 1：
A kind of long-acting bacteriostatic composition, including following component：10 parts of glycerine, 0.1 part of carragheen, hydroxypropyl Sodium Glycinate
0.5 part, 1 part of natural plant extracts, 0.1 part of salicylic acid, 10 parts of water.
The preparation method of bacteria inhibiting composition is as follows：
1) sol solution of bacteria inhibiting composition is prepared
Carragheen is disperseed with glycerine, adds water afterwards, stirring 100r/min and heating is opened, is incubated at 70 DEG C
20min, after be cooled to 50 DEG C, add natural plant extracts, carboxylic glycinate sodium and salicylic acid thereto, be made antibacterial group
The sol solution of compound；
2) nanometer sol solution is prepared
The sol solution of gained in step 1) is controlled in 0.45~0.55MPa, homogeneous by high pressure homogenizer, feed pressure
200~250MPa of pressure, material are sprayed with the flow velocitys of 1300~1500 meter per seconds, by caused void effect, knock-on effect,
Shearing effect, obtain uniform, fine and smooth, nano level sol solution；
3) porous nano colloid is prepared
The sol solution obtained in step 2) is placed in liquid nitrogen and freezes 30min, refrigerator is transferred to after product fully charge
In preserved in less than -18 DEG C of environment.
Embodiment 2：
A kind of long-acting bacteriostatic composition, including following component：10 parts of propane diols, 20 parts of glycerine, 0.5 part of xanthans, knot are cold
0.5 part of glue, 3 parts of natural plant extracts, 1 part of Phenoxyethanol, 1.5 parts of soluble metyl hydroxybenzoate, 0.2 part of o-phenyl phenol, to chlorine
0.1 part of meta-xylene phenol, 30 parts of water.
The preparation method of bacteria inhibiting composition is as follows：
1) sol solution of bacteria inhibiting composition is prepared
Xanthans and gellan gum are disperseed with propane diols and glycerine, add water afterwards, stirring 200r/min is opened and adds
Heat, 5min is incubated at 90 DEG C, after be cooled to 50 DEG C, thereto add natural plant extracts, Phenoxyethanol, methyl hydroxybenzoate
Sodium, o-phenyl phenol, parachlorometaxylenol, the sol solution of bacteria inhibiting composition is made；
2) nanometer sol solution is prepared
The sol solution of gained in step 1) is controlled in 0.35~0.45MPa, homogeneous by high pressure homogenizer, feed pressure
100~150MPa of pressure, material are sprayed with the flow velocitys of 1100~1200 meter per seconds, by caused void effect, knock-on effect,
Shearing effect, obtain uniform, fine and smooth, nano level sol solution；
3) porous nano colloid is prepared
The sol solution obtained in step 2) is placed in liquid nitrogen and freezes 20min, refrigerator is transferred to after product fully charge
In preserved in less than -18 DEG C of environment.
Embodiment 3：
A kind of long-acting bacteriostatic composition, including following component：20 parts of glycerine, 20 parts of butanediol, 10 parts of propane diols, hyalomitome
Sour 0.5 part of sodium, 0.5 part of cellulose gum, 1 part of hydroxypropyl methyl cellulose, 2 parts of methylisothiazolinone, 3 parts of sodium sorbate, day
Right 5 parts of plant extracts, 0.2 part of salicylic acid, 0.3 part of triclosan, 50 parts of water.
The preparation method of bacteria inhibiting composition is as follows：
1) sol solution of bacteria inhibiting composition is prepared
Sodium Hyaluronate, cellulose gum, hydroxypropyl methyl cellulose are disperseed with glycerine, butanediol and propane diols,
After add water, open stirring 150r/min and heating, 30min be incubated at 70 DEG C, after be cooled to 50 DEG C, add thereto natural
Plant extracts, methylisothiazolinone, sodium sorbate, salicylic acid and triclosan, the sol solution of bacteria inhibiting composition is made；
2) nanometer sol solution is prepared
The sol solution of gained in step 1) is controlled in 0.35~0.45MPa, homogeneous by high pressure homogenizer, feed pressure
50~100MPa of pressure, material are sprayed with the flow velocity of 1100~1200 meter per seconds, by caused void effect, knock-on effect, cut
Effect is cut, obtains uniform, fine and smooth, nano level sol solution；
3) porous nano colloid is prepared
The sol solution obtained in step 2) is placed in liquid nitrogen and freezes 30min, refrigerator is transferred to after product fully charge
In preserved in less than -18 DEG C of environment.
Embodiment 4：
A kind of long-acting bacteriostatic composition, including following component：- 60010 parts of polyethylene glycol, 0.1 part of cellulose gum, double (hydroxyls
Methyl) 2 parts of imidazolidinyl urea, 3 parts of methylchloroisothiazandnone, 3 parts of natural plant extracts, 0.5 part of salicylic acid, 50 parts of water.
The preparation method of bacteria inhibiting composition is as follows：
1) sol solution of bacteria inhibiting composition is prepared
Cellulose gum is disperseed with PEG-4000, adds water afterwards, stirring 150r/min and heating are opened, in 80
30min is incubated at DEG C, after be cooled to 50 DEG C, thereto add Bis(hydroxymethyl)imidazolidinyl urea, methylchloroisothiazandnone, day
Right plant extracts and salicylic acid, the sol solution of bacteria inhibiting composition is made；
2) nanometer sol solution is prepared
The sol solution of gained in step 1) is controlled in 0.35~0.45MPa, homogeneous by high pressure homogenizer, feed pressure
50~100MPa of pressure, material are sprayed with the flow velocity of 1100~1200 meter per seconds, by caused void effect, knock-on effect, cut
Effect is cut, obtains uniform, fine and smooth, nano level sol solution；
3) porous nano colloid is prepared
The sol solution obtained in step 2) is placed in liquid nitrogen and freezes 30min, refrigerator is transferred to after product fully charge
In preserved in less than -18 DEG C of environment.
Embodiment 5：
A kind of long-acting bacteriostatic composition, including following component：10 parts of glycerine, 10 parts of butanediol, -60030 parts of polyethylene glycol,
0.5 part of Sodium Hyaluronate, 0.5 part of cellulose gum, 1 part of hydroxypropyl methyl cellulose, 0.5 part of sodium sorbate, extracted form natural plant
3 parts of thing, 0.1 part of triclosan, 10 parts of water.
The preparation method of bacteria inhibiting composition is as follows：
1) sol solution of bacteria inhibiting composition is prepared
Sodium Hyaluronate, cellulose gum, hydroxypropyl methyl cellulose are carried out with glycerine, butanediol and polyethylene glycol -600
It is scattered, add water afterwards, open stirring 150r/min and heating, 30min is incubated at 60 DEG C, after be cooled to 50 DEG C, thereto plus
Enter natural plant extracts, sodium sorbate and triclosan, the sol solution of bacteria inhibiting composition is made；
2) nanometer sol solution is prepared
The sol solution of gained in step 1) is controlled in 0.25~0.35MPa, homogeneous by high pressure homogenizer, feed pressure
50~100MPa of pressure, material are sprayed with the flow velocity of 1100~1200 meter per seconds, by caused void effect, knock-on effect, cut
Effect is cut, obtains uniform, fine and smooth, nano level sol solution；
3) porous nano colloid is prepared
The sol solution obtained in step 2) is placed in liquid nitrogen and freezes 30min, refrigerator is transferred to after product fully charge
In preserved in less than -18 DEG C of environment.
Embodiment 6：
A kind of long-acting bacteriostatic composition, including following component：10 parts of propane diols, 0.5 part of carragheen, 0.5 part of gellan gum, hydroxyl
0.5 part of glycinate sodium, 1.5 parts of soluble metyl hydroxybenzoate, 0.5 part of sodium benzoate, 5 parts of natural plant extracts, sodium salicylate
0.3 part, 10 parts of water.
The preparation method of bacteria inhibiting composition is as follows：
1) sol solution of bacteria inhibiting composition is prepared
Carragheen and gellan gum are disperseed with propane diols, add water afterwards, stirring 100r/min and heating are opened, in 75
15min is incubated at DEG C, after be cooled to 50 DEG C, thereto add natural plant extracts, carboxylic glycinate sodium, methyl hydroxybenzoate
Sodium, sodium benzoate and sodium salicylate, the sol solution of bacteria inhibiting composition is made；
2) nanometer sol solution is prepared
The sol solution of gained in step 1) is controlled in 0.45~0.55MPa, homogeneous by high pressure homogenizer, feed pressure
200~250MPa of pressure, material are sprayed with the flow velocitys of 1300~1500 meter per seconds, by caused void effect, knock-on effect,
Shearing effect, obtain uniform, fine and smooth, nano level sol solution；
3) porous nano colloid is prepared
The sol solution obtained in step 2) is placed in liquid nitrogen and freezes 30min, refrigerator is transferred to after product fully charge
In preserved in less than -18 DEG C of environment.
Embodiment 7：
A kind of long-acting bacteriostatic composition, including following component：10 parts of propane diols, 20 parts of butanediol, 0.5 part of xanthans, knot
0.5 part of cold glue, 1 part of cellulose gum, 0.5 part of o-phenyl phenol, 3 parts of natural plant extracts, 0.5 part of benzalkonium chloride, 10 parts of water.
The preparation method of bacteria inhibiting composition is as follows：
1) sol solution of bacteria inhibiting composition is prepared
Xanthans, gellan gum and cellulose gum are disperseed with propane diols and butanediol, add water afterwards, opens stirring
200r/min and heating, 5min is incubated at 90 DEG C, after be cooled to 50 DEG C, add o-phenyl phenol and benzalkonium chloride thereto,
The sol solution of bacteria inhibiting composition is made；
2) nanometer sol solution is prepared
The sol solution of gained in step 1) is controlled in 0.25~0.35MPa, homogeneous by high pressure homogenizer, feed pressure
100~120MPa of pressure, material are sprayed with the flow velocitys of 1100~1200 meter per seconds, by caused void effect, knock-on effect,
Shearing effect, obtain uniform, fine and smooth, nano level sol solution；
3) porous nano colloid is prepared
The sol solution obtained in step 2) is placed in liquid nitrogen and freezes 20min, refrigerator is transferred to after product fully charge
In preserved in less than -18 DEG C of environment.
Embodiment 8：
A kind of long-acting bacteriostatic composition, including following component：15 parts of butanediol, -60015 parts of polyethylene glycol, xanthans 0.5
Part, 0.5 part of gellan gum, 1 part of cellulose gum, 3 parts of iodine propilolic alcohol butyl mephenesin Carbamate, 2 parts of sodium sorbate, natural plant extracts
1 part, 0.3 part of benzalkonium chloride, 50 parts of water.
The preparation method of bacteria inhibiting composition is as follows：
1) sol solution of bacteria inhibiting composition is prepared
Xanthans, gellan gum and cellulose gum are disperseed with butanediol and PEG-4000, add water afterwards, is opened
Stir 200r/min and heating, 5min be incubated at 90 DEG C, after be cooled to 50 DEG C, add iodine propilolic alcohol butyl ammonia formic acid thereto
Ester, sodium sorbate, natural plant extracts and benzalkonium chloride, the sol solution of bacteria inhibiting composition is made；
2) nanometer sol solution is prepared
The sol solution of gained in step 1) is controlled in 0.25~0.35MPa, homogeneous by high pressure homogenizer, feed pressure
100~120MPa of pressure, material are sprayed with the flow velocitys of 1100~1200 meter per seconds, by caused void effect, knock-on effect,
Shearing effect, obtain uniform, fine and smooth, nano level sol solution；
3) porous nano colloid is prepared
The sol solution obtained in step 2) is placed in liquid nitrogen and freezes 20min, refrigerator is transferred to after product fully charge
In preserved in less than -18 DEG C of environment.
Embodiment 9：
A kind of long-acting bacteriostatic composition, including following component：20 parts of glycerine, 20 parts of butanediol, 10 parts of propane diols, hyalomitome
Sour 0.5 part of sodium, 0.5 part of cellulose gum, 2 parts of methylisothiazolinone, 0.5 part of sodium sorbate, 1 part of natural plant extracts, water
Poplar acid 0.2 part, 0.3 part of triclosan, 30 parts of water.
The preparation method of bacteria inhibiting composition is as follows：
1) sol solution of bacteria inhibiting composition is prepared
Sodium Hyaluronate, cellulose gum are disperseed with glycerine, butanediol and propane diols, add water afterwards, opens stirring
150r/min and heating, 30min is incubated at 70 DEG C, after be cooled to 50 DEG C, it is different to add natural plant extracts, methyl thereto
Thiazolinone, sodium sorbate, salicylic acid and triclosan, the sol solution of bacteria inhibiting composition is made；
2) nanometer sol solution is prepared
The sol solution of gained in step 1) is controlled in 0.35~0.45MPa, homogeneous by high pressure homogenizer, feed pressure
50~100MPa of pressure, material are sprayed with the flow velocity of 1100~1200 meter per seconds, by caused void effect, knock-on effect, cut
Effect is cut, obtains uniform, fine and smooth, nano level sol solution；
3) porous nano colloid is prepared
The sol solution obtained in step 2) is placed in liquid nitrogen and freezes 30min, refrigerator is transferred to after product fully charge
In preserved in less than -18 DEG C of environment.
2nd, hand cleanser
Embodiment 1：
A kind of hand cleanser, its component are as mass fraction：Cocoamidopropyl betaine 2%, potassium lauroyl sarcosine
3%th, sorbierite 1%, butanediol 1.5%, trehalose 1.5%, methyl dioleate 1%, OXYBENZONE 1%, EDTA bis-
Sodium 0.05%, glyceryl cocoate 1%, flavoring orange essence 0.5%, bacteria inhibiting composition 0.2%, Phenoxyethanol 0.1%, water
87.15%.
Embodiment 2：
A kind of hand cleanser, its component fraction by weight are calculated as：Laureth sodium sulfovinate 3%, Plantacare 818 3%,
Laureth sulfosuccinate disodium 5%, Cocoamidopropyl betaine 5%, glycerine 0.5%, sodium chloride 0.5%, second
Glycol monostearate 1%, styrene/acrylic (ester) analog copolymer 0.5%, the sodium 0.01% of EDTA tetra-, glycerine polyacrylic acid
Ester 0.5%, flavoring apple essence 1%, bacteria inhibiting composition 1%, sorbic acid 0.5%, water 79.49%.
Embodiment 3：
A kind of hand cleanser, its component fraction by weight are calculated as：Cocounut oil diglycollic amide 2%, potassium lauroyl sarcosine 3%,
Plantacare 818 5%, laureth sulfosuccinate disodium 5%, oleth -105%, cocamidopropyl propyl amide PG- bis-
Ammonio methacrylate phosphate 5%, propane diols 2%, pyrrolidone sodium carboxylate 3%, hydroxypropyl methyl cellulose 1%, acrylic acid
The smooth sesquialter caprylate of (ester) copolymer 0.5%, pigment 0.001%, EDETATE SODIUM 0.03%, glycerine polyacrylate 1%, sorb
1%th, flavoring apple essence 0.2%, bacteria inhibiting composition 2%, soluble metyl hydroxybenzoate 1%, water 63.269%.
Embodiment 4：
A kind of hand cleanser, its component fraction by weight are calculated as：Laureth sodium sulphate 8%, Plantacare 818 2%, coconut palm
Oleamide MEA 2%, Cocoamidopropyl betaine 4%, glycerine 2%, PEG-4000 3%, hydroxypropyl methyl cellulose
0.2%th, the sodium 0.05% of styrene/acrylic (ester) copolymer 1 %, EDTA tetra-, 12-15 alcohol lactate 1.5%, cherry essence
0.5%th, bacteria inhibiting composition 1%, sodium chloride 0.5%, sodium hydroxy methyl glycinate 0.3%, water 73.95%.
The preparation method of above-mentioned hand cleanser is：Thickening stabilizing agent is dispersed in the NMF of part, with surfactant, profit
Skin agent, metal ion chelation agent, water are added in kettle in the lump, are warming up to 80~85 DEG C, are started to cool after being incubated 20min, are cooled to
45 DEG C, after bacteria inhibiting composition, appearance modifying agents are scattered in remaining NMF and remaining water respectively, add in kettle, and to kettle
Middle addition essence and preservative, after being uniformly dispersed, filling after inspection by sampling is qualified is hand cleanser finished product.
In order to verify the actual effect of bacteria inhibiting composition and hand cleanser provided by the invention, We conducted following test：
The contrast experiment of hand fungistatic effect
1. subject selects and packet
Examination is carried out to volunteer using the evaluation criterion included and excluded, (people of male 25, women 35 by 60 volunteers
People) 2 groups are randomly divided into, every group of 30 people, checked using mono blind method.Two groups tested group begins to use suppression in before the test 2 weeks
Bacterium hand cleanser, the tested group of hand cleanser for using embodiment 2, control group use the hand cleanser for being not added with bacteria inhibiting composition of the present invention.
2. Index for examination
After being cleaned respectively with hand cleanser progress hand, continue sampling determination volunteer's hand skin bacterium number.
3. experiment flow
The ASTM standard that the method for sampling tests association's formulation according to Britain is adopted, sampling a diameter of 5cm sampling cups and plastics
Sampling rod, with making Bacteria Culture after pipette collecting sample.Nertralizer efficiency assay, carried out by GB15979-2002 appendix Cs
Checking.Neutralization sample solution is sodium thiosulfate containing 5g/L, 30g/L lecithin, the sterilizing phosphoric acid buffer of 50g/L Tween 80s preparation
Liquid.With 30min, 12h, 24h, 48h, 96h after sterilization respectively before sterilization, respectively sampling 1 time, does Bacteria Culture.Antibacterial validity
The logarithm value that 30min bacterium numbers reduce after experiment skin antiseptic sterilization answers ＞ 1, tests just effective；The bacterium number sampled every time later
Reduction is compared with exponential curve base value and then illustrates that disinfectant has bacteriostatic activity at the time point.
4. hand washing
First hand is moistened with circulating water, takes 2mL hand cleanser, naturally dry after being washed one's hands by " Six Steps ".
5. statistical method
Statistical method uses the software kits of SPSS 11.5, calculates antibacterial using volunteer's skin of two kinds of bacteriostatic hand sanitizers
Exponential curve.
6. experimental result
Skin bacterium average is respectively 2.72 and 2.68lg cfu/mL before two groups of volunteer's sterilizations；Skin after sterilization 30min
Bacterium is greatly decreased to 0.25 and 0.24lg cfu/mL.
Control group volunteer's hand bacterial population is can be seen that from the correction data of upper table to have a rebound quickly, and subject
Fungistatic effect when fungistatic effect and control group 2h of the volunteer after 8h is suitable, thus provided by the invention contains this antibacterial group
The hand cleanser of compound shows the effect of antibacterial sustained release, long-acting bacteriostatic in volunteer's hand.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (10)
- A kind of 1. long-acting bacteriostatic composition, it is characterised in that by weight, including following component：Polyalcohol 10-50 parts, increase Thick dose of 0.1-2 part, preservative 0.5-5 parts, natural plant extracts 1-5 parts, chemical bacteriostatic agent 0.1-0.5 parts, water 10-50 parts, Wherein, the natural plant extracts are chamomile, tealeaves and the leaf of bamboo in mass ratio 1:1:The water extraction of gained mixture after 1 mixing Take thing.
- 2. long-acting bacteriostatic composition according to claim 1, it is characterised in that the polyalcohol is glycerine, butanediol, third One or more of mixtures in glycol, Macrogol 600；The thickener is carragheen, gellan gum, xanthans, hydroxypropyl One or more of mixtures in ylmethyl cellulose, Sodium Hyaluronate, cellulose gum.
- 3. long-acting bacteriostatic composition according to claim 1, it is characterised in that the preservative is Phenoxyethanol, Ni Bo Tortoise beetle ester sodium, nipagin A sodium, sodium benzoate, sodium hydroxy methyl glycinate, methylisothiazolinone, methyl chloride isothiazoline One or more of mixtures in ketone, Bis(hydroxymethyl)imidazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, sodium sorbate.
- 4. long-acting bacteriostatic composition according to claim 1, it is characterised in that the chemical bacteriostatic agent is diformazan chlorine One or more of mixing in phenol, o-phenyl phenol, BZK, salicylic acid, sodium salicylate, triclosan, triclocarban Thing.
- 5. the long-acting bacteriostatic composition according to right will go 1, it is characterised in that the extraction work of the natural plant extracts Skill is：Solid-liquid ratio 1:20,90 DEG C of Extracting temperature, extraction time 2h.
- 6. the preparation method of the long-acting bacteriostatic composition any one of a kind of claim 1-5, it is characterised in that including such as Lower step：1) sol solution of bacteria inhibiting composition is preparedBy thickener disperse polyol, water is added afterwards, opens stirring and heating, 10-60min is incubated at 50-90 DEG C, rear drop Temperature adds natural plant extracts, chemical bacteriostatic agent and preservative, stirred thereto to 50 DEG C, and bacteria inhibiting composition is made Sol solution；2) nanometer sol solution is preparedThe sol solution of gained in step 1) is sprayed by high-pressure homogeneous equipment, material with the flow velocity of 1000~1500 meter per seconds, led to Caused void effect, knock-on effect, shearing effect are crossed, obtains uniform, fine and smooth, nano level sol solution；3) porous nano colloid is preparedThe sol solution obtained in step 2) is placed in liquid nitrogen and freezed, is transferred to after product fully charge in refrigerator in -18 DEG C Preserved in following environment.
- 7. preparation method according to claim 6, it is characterised in that the feed pressure control of step 2) mesohigh homogenizer System is in 0.35~0.55MPa, 50~250MPa of homogenization pressure.
- 8. a kind of hand cleanser, it is characterised in that including the long-acting bacteriostatic composition as any one of claim 1-5.
- 9. hand cleanser according to claim 8, it is characterised in that fraction meter by weight, including following component：Surface-active Agent 5-25%, NMF 0.5-5%, thickening stabilizing agent 0.5-2.5%, appearance modifying agents 0.001-1.5%, metal ion-chelant Agent 0.01-0.05%, emollient 0.5-2.0%, essence 0.2-1.0%, long-acting bacteriostatic composition 0.2-2.0%, preservative 0.1-1%, surplus are water.
- 10. hand cleanser according to claim 9, it is characterised in that the surfactant is laureth sulfuric ester Sodium, bay alcohol sulfuric ester ammonium, LAA, Cocoamidopropyl betaine, coconut monoethanol amide, cocounut oil two Glycollic amide, potassium lauroyl sarcosine, Plantacare 818, cocoyl glucoside, laureth sulfosuccinate disodium, oil One or more of mixtures in alcohol polyethers -10, cocamidopropyl propyl amide pg dimonium chloride phosphate；The NMF is propane diols, butanediol, polyethylene glycol 400, glycerine, sorbierite, pyrrolidone sodium carboxylate, aminomethyl third One or more of mixtures in alcohol；The thickening stabilizing agent is methyl dioleate, hydroxypropyl methyl cellulose, trehalose, sodium chloride, acrylic acid (ester) copolymer, two (hydrogenated-tallow group) phthalic acid amides, carbomer, acrylic acid (ester) class/C10-30 alkylol acrylamides acid One or more of mixtures in ester cross-linked polymer, guar hydroxypropyltrimonium chloride, polyquaternium -37；The appearance modifying agents are OXYBENZONE, UVNUL MS-40, styrene/acrylic (ester) analog copolymer, pigment, ethylene glycol two One or more of mixtures in stearate, ethylene glycol monostearate；The metal ion chelation agent be EDETATE SODIUM, One or more of mixtures in the sodium of EDTA tetra-；The emollient is glyceryl cocoate, C12-15 alcohol lactate, castor oil-base maleic acid esters, glycerine polyacrylic acid The smooth sesquialter caprylate of ester, sorb, the dimethyl silicone polymer of polyethylene glycol -14, the caprylic/capric of polyethylene glycol -6 glyceride type, Jiao Palmyra palm oleate, the decylate of polyglycereol -3, one kind in double-dimethyl silicone polymer of polyethylene/polypropylene glycol -20/20 or Several mixtures；The preservative is Phenoxyethanol, pungent glycol, sorbic acid, dehydroactic acid, soluble metyl hydroxybenzoate, nipagin A sodium, benzene Sodium formate, sodium hydroxy methyl glycinate, methylisothiazolinone, methylchloroisothiazandnone, imidazolidinyl urea, double (methylol) miaows Oxazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, sodium sorbate, in one or more of mixtures.
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Application publication date: 20171201 |