CN109939030A - A kind of hand cleanser and preparation method thereof of natural bacteriostatic anti-inflammatory - Google Patents
A kind of hand cleanser and preparation method thereof of natural bacteriostatic anti-inflammatory Download PDFInfo
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Abstract
The invention discloses a kind of hand cleanser and preparation method thereof of natural bacteriostatic anti-inflammatory; it is raw material that the hand cleanser, which is by Chinese medicine composition extract and lauryl sodium sulfate, deionized water, lauroyl propylhomoserin sodium, Cocoamidopropyl betaine, potassium sorbate, citric acid, glycerol, essential oil, is aided with suitable auxiliary material and is prepared；It include following component: angelica extract, Herba Andrographitis alcohol extract, philippine flemingia root alcohol extract, leatherleaf mahonia, single side needle water extract, cherokee rose root, Caulis Spatholobi, Radix Codonopsis water extract in the Chinese medicine composition extract；Natural bacteriostatic anti-inflammatory hand cleanser viscosity of the present invention is good, and foaming characteristic is good, strong detergency, and flushing performance is good, no any chemical component addition, and has inhibiting bacteria and diminishing inflammation effect, can nursing skin；The preparation method of hand cleanser of the present invention is easy to operate, is with a wide range of applications.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, hand cleanser and its preparation more particularly, to a kind of natural bacteriostatic anti-inflammatory
Method.
Background technique
Promotion with people's living standard and the enhancing to health consciousness, China resident to the demand of hand cleanser not
It is disconnected to increase.Currently, hand cleanser has become the necessary article of people's daily life, product category is increasing, and progressively towards
Environmentally protective, functionalization, specially to change, the direction of seriation is developed.It is required in addition to the existing brand production in market meets general cleaning
Product outside, market product shows following several big types one after another: fragrance, natural, functional, special Xiang Huasi major class.But it is existing
The not creative quality for improving product of commercially available hand cleanser, hand cleanser has a single function, with chemical formulation class hand cleanser
In the majority, chemical formulation hand cleanser residual is strong, injures skin.
Currently, the type of germ is more, propagate fastly, many infectious diseases are caused by germ, especially winter, room ventilation
Effect is bad, and the spread speed of germ is especially fast, and especially the elderly, the chance of children's disease carrying germ are more, and germ infects
Enter the in the majority of respiratory tract by hand.
Therefore, consumer remained further need for one kind can pre- preventing germs infection and washability is good, faint scent, nontoxic secondary makees
Natural hand cleanser, during daily cleaning, energy inhibiting bacteria and diminishing inflammation prevents bacterial virus from invading body, prevents the hair of disease
It is raw.
In view of the above-mentioned problems, applicant Zhuzhou Qianjin Pharmacy Co., Ltd develops, one kind is environmentally protective, naturally may be used
It degrades, washing effect is good, the natural hand cleanser of inhibiting bacteria and diminishing inflammation, pre- preventing germs infection.
Summary of the invention
The technical problem to be solved by the present invention is to for hand cleanser in the prior art do not have it is environmentally protective, do not have it is antibacterial
The effect of anti-inflammatory, and the technical deficiency that using effect is bad, provide a kind of natural hand cleanser with inhibiting bacteria and diminishing inflammation, solve existing
There is hand cleanser in technology not have the effect of environmentally protective, without inhibiting bacteria and diminishing inflammation, and the problem that using effect is bad.
Another technical problems to be solved of the present invention are to provide the preparation method of above-mentioned hand cleanser.
The purpose of the present invention is achieved by the following technical programs:
A kind of hand cleanser of natural bacteriostatic anti-inflammatory is provided, the hand cleanser is by Chinese medicine composition extract and dodecyl sulphur
Sour sodium, deionized water, lauroyl propylhomoserin sodium, Cocoamidopropyl betaine, potassium sorbate, citric acid, glycerol, essential oil
For raw material, it is aided with suitable auxiliary material and is prepared, the Chinese medicine composition extract includes following composition: angelica extract；It wears
Heart lotus alcohol extract；Philippine flemingia root alcohol extract；Leatherleaf mahonia, single side needle water extract；Cherokee rose root, Caulis Spatholobi, Radix Codonopsis water extract.
Further, the hand cleanser includes the raw material of following mass parts: 2~8 parts of Chinese medicine composition extract, dodecane
5~10 parts of base sodium sulphate, 60~75 parts of deionized water, 5~10 parts of lauroyl propylhomoserin sodium, Cocoamidopropyl betaine 5~
10 parts, 1~2 part of potassium sorbate, 1~5 part of citric acid, 2~6 parts of glycerol, 0.1~0.5 part of essential oil.
Preferably, the hand cleanser includes the raw material of following mass parts: 2~6 parts of Chinese medicine composition extract, dodecyl
5~8 parts of sodium sulphate, 60~70 parts of deionized water, 5~8 parts of lauroyl propylhomoserin sodium, 5~8 parts of Cocoamidopropyl betaine,
1~2 part of potassium sorbate, 1~3 part of citric acid, 4~5 parts of glycerol, 0.1~0.5 part of essential oil.
Preferably, the hand cleanser includes the raw material of following mass parts: 4 parts of Chinese medicine composition extract, dodecyl sulphur
6 parts of sour sodium, 70 parts of deionized water, 6 parts of lauroyl propylhomoserin sodium, 6 parts of Cocoamidopropyl betaine, 1.5 parts of potassium sorbate, lemon
Lemon acid 2 parts, 4 parts of glycerol, 0.5 part of essential oil.
Further, the Chinese medicine composition extract includes the ingredient of following mass parts: 8~10 parts of angelica extract,
8~10 parts of Herba Andrographitis alcohol extract, 8~12 parts of philippine flemingia root alcohol extract, leatherleaf mahonia, 20~30 parts of single side needle water extract, cherokee rose root, chicken
40~50 parts of blood rattan, Radix Codonopsis water extract.
Preferably, the Chinese medicine composition extract includes the ingredient of following mass parts: 9 parts of angelica extract, Herba Andrographitis
9 parts of alcohol extract, 10 parts of philippine flemingia root alcohol extract, leatherleaf mahonia, 25 parts of single side needle water extract, cherokee rose root, Caulis Spatholobi, Radix Codonopsis water extract 47
Part.
Further, the leatherleaf mahonia, in single side needle water extract, the mass ratio of each ingredient are as follows: 14~18:8~10, it is described
During cherokee rose root, Caulis Spatholobi, Radix Codonopsis water extract, the mass ratio of each ingredient are as follows: 14~18:14~18:8~10.
Preferably, the leatherleaf mahonia, in single side needle water extract, the mass ratio of each ingredient is 16:9, the cherokee rose root, chicken blood
During rattan, Radix Codonopsis water extract, the mass ratio of each ingredient are as follows: 16:16:9.
Preferably, the citric acid is the citric acid being added after deionized water dissolving, and the mass concentration of the citric acid is
20~40%.
Preferably, the mass concentration of the citric acid is 30%.
Further, the hand cleanser preparation method the following steps are included:
S11. the Radix Angelicae Sinensis for taking formula ratio, with 0.5 times of its quality measure volume 75% ethyl alcohol extract, extraction temperature be 35~
38 DEG C, extracting pressure 20Mpa, parsing pressure is 8Mpa, CO2Flow is 8L/h, and extraction time is 2~4h, collects extract,
Up to the angelica extract；
S12. the Herba Andrographitis for taking formula ratio is extracted with 70~85% alcohol reflux, recycles ethyl alcohol, and filtrate is condensed into clearly
Cream, obtains Andrographis Paniculata, and filter residue is spare；
S13. the philippine flemingia root for taking formula ratio, 65~80% alcohol refluxs for measuring volume with 6~8 times of philippine flemingia root quality extract 2
Secondary, 1~3h, combined extract, filtrate are concentrated and dried into dry cream every time, and 2~4L is diluted and be settled to 65~80% ethyl alcohol, on
It states solution and flings to ethyl alcohol, the water measured with 6~10 times dilutes, macroporous resin column on aqueous, and resin column dosage is that water dilution is molten
4~6 times of liquid product, are first eluted with water, and the dosage of water is 4~6 times of water dilute solution, flow control in 6~10ml/min, then
With 60% ethanol elution, for flow control in 6~10ml/min, it is colourless to be eluted to eluent, collects ethanol eluate, filters, filter
The clear cream that relative density is 1.08~1.12 when liquid is concentrated into 80 DEG C, obtains philippine flemingia root alcohol extract；
S14. leatherleaf mahonia, the single side needle for taking formula ratio in proportion are decocted 2 times with water, and water consumption is two taste Chinese medicine total weights
8~10 times amount, decocting time be 2~3 hours, collecting decoction, filtration, when filtrate is concentrated into 80 DEG C relative density be 1.08~
1.12 clear cream obtains leatherleaf mahonia, single side needle water extract；
S15. cherokee rose root, Caulis Spatholobi, the Radix Codonopsis for taking formula ratio in proportion are decocted 2 times with water, and for the first time plus three taste Chinese medicines are total
The water of 4~10 times of weight amounts, the dregs of a decoction after extracting for the first time add the resulting Herba Andrographitis dregs of a decoction of S12 to decoct 2 hours together, amount of water
For 4~10 times of amounts of four taste Chinese medicine total weights, collecting decoction, filtration, filtrate, which merges, to be concentrated, and obtains cherokee rose root, Caulis Spatholobi, Radix Codonopsis water
Extract；
S16. above-mentioned five kinds of extracts mixed in proportion, be watered dissolution, make the water content 20~35% of extract, i.e.,
Obtain Chinese medicine composition extract；
S2. the preparation of hand cleanser, it is described preparation the following steps are included:
S21. lauryl sodium sulfate, deionized water are proportionally added into, are heated to 60~80 DEG C, stir evenly, until complete
It is complete miscible；
S22. lauroyl propylhomoserin sodium, Cocoamidopropyl betaine are proportionally added into S21 products therefrom, at a slow speed
It stirs evenly, stops heating, placement is cooled to 40~50 DEG C, is proportionally added into Chinese medicine composition extract, the sorb of S1 preparation
Sour potassium stirs to clarify；
S23. citric acid is dissolved in deionized water, the citric acid that mass concentration is 20~40% is configured to, to S22 institute
After obtaining product cooling, citric acid is added by formula rate, is stirring evenly and then adding into glycerol, sufficiently dissolves it to all substances
Afterwards, essential oil is added dropwise, stirs evenly at a slow speed to get hand cleanser of the present invention.
The invention has the following advantages:
1, the Chinese medicine composition extract in product of the present invention and the mutual compatibility of other compositions, optimum organization, so that preparation
Product viscosity it is good, foaming characteristic is good, strong detergency, rinse performance is good, wash after can nursing skin, and have inhibiting bacteria and diminishing inflammation, pre-
The effect of preventing germs infection.
2, main inhibiting bacteria and diminishing inflammation ingredient in product of the present invention is Chinese medicine composition extract, and inventor's Accurate Analysis should
Main component and its interaction in composition material, Radix Angelicae Sinensis are extracted using Ethanol supercritical extraction, a greater degree of to protect
Effective component in Radix Angelicae Sinensis also more can adequately extract effective component, and Herba Andrographitis is extracted using alcohol reflux, suppression therein
Bacterium anti-inflammatory effective component andrographolide and Dehydro and drographolide can extract to the greatest extent, the independent alcohol extracting of philippine flemingia root,
Its main inhibiting bacteria and diminishing inflammation ingredient genistin and genistein quickly can be extracted adequately, and leatherleaf mahonia, the combination of single side needle mention
It takes, other three kinds of medicinal materials combinations are extracted, so that mutually synergistic between each ingredient, antibacterial, antiphlogistic activity is significantly increased, and are washed
Other compositions compatible use in hand liquid, both can be with antibacterial anti-inflammatory, and when product use has cleaning, comfortable, health-care and skin-care effect again.
3, the raw material in the present invention is to extract in natural materials or Chinese medicine, is not added with any synthesis chemical component, makes
Used time soft touch, washability is good, and to skin without any stimulation, including hand injury skin can be used, using by
It, can not only be to wound inhibiting bacteria and diminishing inflammation, moreover it is possible to wound be promoted to heal as early as possible when hurting on skin.
Meanwhile after this product use, there are natural Chinese medicine faint scent for hand, in the essential oil that collaboration is added, so that product
Fragrance more faint scent it is pleasant.
4, traditional Chinese medicine composition extract liquid of the present invention and hand cleanser long shelf-life, stability is high, and inhibiting bacteria and diminishing inflammation effect is held
Long, it cannot be only used in hand cleanser, it may also be used in other cleaning products.
5, the raw material that product of the present invention uses is easy to get, and preparation method is easy, environmentally protective, is suitable for large-scale production,
It has a good application prospect.
6, tests prove that, product of the present invention, the significant effect in inhibiting bacteria and diminishing inflammation effect.
Specific embodiment
Further illustrate the present invention below in conjunction with specific embodiment, but embodiment the present invention is not done it is any type of
It limits.Unless stated otherwise, the present invention uses reagent, method and apparatus is the art conventional reagents, method and apparatus.
Unless stated otherwise, following embodiment agents useful for same and material are commercially available.
A kind of hand cleanser and preparation method thereof of the natural bacteriostatic anti-inflammatory of embodiment 1
(1) be formulated: in raw material include following mass component: 4 parts of Chinese medicine composition extract, 6 parts of lauryl sodium sulfate,
70 parts of deionized water, 6 parts of lauroyl propylhomoserin sodium, 6 parts of Cocoamidopropyl betaine, 1.5 parts of potassium sorbate, 2 parts of citric acid,
4 parts of glycerol, 0.5 part of essential oil；The mass parts of each ingredient in the Chinese medicine composition extract are as follows: 9 parts of angelica extract, wear
9 parts of heart lotus alcohol extract, 10 parts of philippine flemingia root alcohol extract, leatherleaf mahonia, 25 parts of single side needle water extract, cherokee rose root, Caulis Spatholobi, Radix Codonopsis water mention
47 parts of object；In the leatherleaf mahonia, single side needle water extract, the mass ratio of leatherleaf mahonia and single side needle is 16:9, the cherokee rose root, chicken blood
In rattan, Radix Codonopsis water extract, the mass ratio of each ingredient is 16:16:9, and the citric acid is the lemon being added after deionized water dissolving
Acid.
(2) preparation method:
S1. the preparation of Chinese medicine composition extract, it is described preparation the following steps are included:
S11. the Radix Angelicae Sinensis for taking formula ratio, 75% ethyl alcohol for measuring volume with 0.5 times of its quality extract, extraction temperature 36
DEG C, extracting pressure 20Mpa, parsing pressure is 8Mpa, CO2Flow is 8L/h, extraction time 3h, collect extract to get
The angelica extract；
S12. the Herba Andrographitis for taking formula ratio is extracted with 80% alcohol reflux, recycles ethyl alcohol, and filtrate is condensed into clear cream, obtains
Andrographis Paniculata, filter residue are spare；
S13. the philippine flemingia root for taking formula ratio, with the extraction of 75% alcohol reflux 2 times of 7 times of philippine flemingia root quality amount volumes, every time
2h, combined extract, filtrate are concentrated and dried into dry cream, and 3L is diluted and be settled to 75% ethyl alcohol, and above-mentioned solution flings to ethyl alcohol, use
The water of 8 times of amounts dilutes, and macroporous resin column on aqueous, resin column dosage is 5 times of water dilute solution volume, is first drenched with water
It washes, the dosage of water is 5 times of water dilute solution, and flow control is in 8ml/min, then with 60% ethanol elution, and flow control is in 8ml/
Min, it is colourless to be eluted to eluent, collects ethanol eluate, filtration, relative density is 1.08~1.12 when filtrate is concentrated into 80 DEG C
Clear cream, obtain philippine flemingia root alcohol extract；
S14. leatherleaf mahonia, the single side needle for taking formula ratio in proportion are decocted 2 times with water, and water consumption is two taste Chinese medicine total weights
9 times amount, decocting time be 2.5 hours, collecting decoction, filtration, when filtrate is concentrated into 80 DEG C relative density be 1.08~1.12
Clear cream, obtain leatherleaf mahonia, single side needle water extract；
S15. cherokee rose root, Caulis Spatholobi, the Radix Codonopsis for taking formula ratio in proportion are decocted 2 times with water, and for the first time plus three taste Chinese medicines are total
The water of 8 times of weight amounts, the dregs of a decoction after extracting for the first time add the resulting Herba Andrographitis dregs of a decoction of S12 to decoct together 2 hours, amount of water four
8 times of amounts of taste Chinese medicine total weight, collecting decoction, filtration, filtrate merge concentration, obtain cherokee rose root, Caulis Spatholobi, Radix Codonopsis water extract；
S16. above-mentioned five kinds of extracts mixed in proportion, be watered dissolution, make the water content 30% of extract to get in
Drug composition extract；
S2. the preparation of hand cleanser, it is described preparation the following steps are included:
S21. lauryl sodium sulfate, deionized water are proportionally added into, are heated to 70 DEG C, stir evenly, until completely mixed
It is molten；
S22. lauroyl propylhomoserin sodium, Cocoamidopropyl betaine are proportionally added into S21 products therefrom, at a slow speed
It stirs evenly, stops heating, placement is cooled to 45 DEG C, is proportionally added into Chinese medicine composition extract, the potassium sorbate of S1 preparation
It stirs to clarify；
S23. citric acid is dissolved in deionized water, is configured to the citric acid that mass concentration is 30%, to be produced obtained by S22
After object is cooling, citric acid is added by formula rate, is stirring evenly and then adding into glycerol, after sufficiently being dissolved to all substances,
Essential oil is added dropwise, stirs evenly at a slow speed to get hand cleanser of the present invention.
A kind of hand cleanser and preparation method thereof of the natural bacteriostatic anti-inflammatory of embodiment 2
(1) be formulated: in raw material include following mass component: 2 parts of Chinese medicine composition extract, 5 parts of lauryl sodium sulfate,
60 parts of deionized water, 10 parts of lauroyl propylhomoserin sodium, 10 parts of Cocoamidopropyl betaine, 2 parts of potassium sorbate, 5 parts of citric acid,
5.9 parts of glycerol, 0.1 part of essential oil；The mass parts of each ingredient in the Chinese medicine composition extract are as follows: 8 parts of angelica extract,
8 parts of Herba Andrographitis alcohol extract, 8 parts of philippine flemingia root alcohol extract, leatherleaf mahonia, 30 parts of single side needle water extract, cherokee rose root, Caulis Spatholobi, Radix Codonopsis water
46 parts of extract；In the leatherleaf mahonia, single side needle water extract, the mass ratio of leatherleaf mahonia and single side needle is 14:10, the cherokee rose root,
In Caulis Spatholobi, Radix Codonopsis water extract, the mass ratio of each ingredient is 14:14:8, and the citric acid is after deionized water dissolving is added
Citric acid.
(2) preparation method:
S1. the preparation of Chinese medicine composition extract, it is described preparation the following steps are included:
S11. the Radix Angelicae Sinensis for taking formula ratio, 75% ethyl alcohol for measuring volume with 0.5 times of its quality extract, extraction temperature 35
DEG C, extracting pressure 20Mpa, parsing pressure is 8Mpa, CO2Flow is 8L/h, extraction time 2h, collect extract to get
The angelica extract；
S12. the Herba Andrographitis for taking formula ratio is extracted with 70% alcohol reflux, recycles ethyl alcohol, and filtrate is condensed into clear cream, obtains
Andrographis Paniculata, filter residue are spare；
S13. the philippine flemingia root for taking formula ratio, with the extraction of 65% alcohol reflux 2 times of 6 times of philippine flemingia root quality amount volumes, every time
1h, combined extract, filtrate are concentrated and dried into dry cream, and 2L is diluted and be settled to 65% ethyl alcohol, and above-mentioned solution flings to ethyl alcohol, use
The water of 6 times of amounts dilutes, and macroporous resin column on aqueous, resin column dosage is 4 times of water dilute solution volume, is first drenched with water
It washes, the dosage of water is 4 times of water dilute solution, and flow control is in 6ml/min, then with 60% ethanol elution, and flow control is in 6ml/
Min, it is colourless to be eluted to eluent, collects ethanol eluate, filtration, relative density is 1.08~1.12 when filtrate is concentrated into 80 DEG C
Clear cream, obtain philippine flemingia root alcohol extract；
S14. leatherleaf mahonia, the single side needle for taking formula ratio in proportion are decocted 2 times with water, and water consumption is two taste Chinese medicine total weights
8 times of amounts, decocting time is 2 hours, and collecting decoction, filtration, relative density is 1.08~1.12 when filtrate is concentrated into 80 DEG C
Clear cream obtains leatherleaf mahonia, single side needle water extract；
S15. cherokee rose root, Caulis Spatholobi, the Radix Codonopsis for taking formula ratio in proportion are decocted 2 times with water, and for the first time plus three taste Chinese medicines are total
The water of 4 times of weight amounts, the dregs of a decoction after extracting for the first time add the resulting Herba Andrographitis dregs of a decoction of S12 to decoct together 2 hours, amount of water four
4 times of amounts of taste Chinese medicine total weight, collecting decoction, filtration, filtrate merge concentration, obtain cherokee rose root, Caulis Spatholobi, Radix Codonopsis water extract；
S16. above-mentioned five kinds of extracts mixed in proportion, be watered dissolution, make the water content 20% of extract to get in
Drug composition extract.
S2. the preparation of hand cleanser, it is described preparation the following steps are included:
S21. lauryl sodium sulfate, deionized water are proportionally added into, are heated to 60 DEG C, stir evenly, until completely mixed
It is molten；
S22. lauroyl propylhomoserin sodium, Cocoamidopropyl betaine are proportionally added into S21 products therefrom, at a slow speed
It stirs evenly, stops heating, placement is cooled to 40 DEG C, is proportionally added into Chinese medicine composition extract, the potassium sorbate of S1 preparation
It stirs to clarify；
S23. citric acid is dissolved in deionized water, is configured to the citric acid that mass concentration is 20%, to be produced obtained by S22
After object is cooling, citric acid is added by formula rate, is stirring evenly and then adding into glycerol, after sufficiently being dissolved to all substances,
Essential oil is added dropwise, stirs evenly at a slow speed to get hand cleanser of the present invention.
A kind of hand cleanser and preparation method thereof of the natural bacteriostatic anti-inflammatory of embodiment 3
(1) be formulated: in raw material include following mass component: 6 parts of Chinese medicine composition extract, 8 parts of lauryl sodium sulfate,
60 parts of deionized water, 10 parts of lauroyl propylhomoserin sodium, 10 parts of Cocoamidopropyl betaine, 2 parts of potassium sorbate, 1 part of citric acid,
.5 parts of glycerol, 0.5 part of essential oil；The mass parts of each ingredient in the Chinese medicine composition extract are as follows: 10 parts of angelica extract,
10 parts of Herba Andrographitis alcohol extract, 12 parts of philippine flemingia root alcohol extract, leatherleaf mahonia, 20 parts of single side needle water extract, cherokee rose root, Caulis Spatholobi, Radix Codonopsis
48 parts of water extract；In the leatherleaf mahonia, single side needle water extract, the mass ratio of leatherleaf mahonia and single side needle is 18:8, the cherokee rose root,
In Caulis Spatholobi, Radix Codonopsis water extract, the mass ratio of each ingredient is 14:18:10, and the citric acid is after deionized water dissolving is added
Citric acid.
(2) preparation method:
S1. the preparation of Chinese medicine composition extract, it is described preparation the following steps are included:
S11. the Radix Angelicae Sinensis for taking formula ratio, 75% ethyl alcohol for measuring volume with 0.5 times of its quality extract, extraction temperature 38
DEG C, extracting pressure 20Mpa, parsing pressure is 8Mpa, CO2Flow is 8L/h, extraction time 4h, collect extract to get
The angelica extract；
S12. the Herba Andrographitis for taking formula ratio is extracted with 85% alcohol reflux, recycles ethyl alcohol, and filtrate is condensed into clear cream, obtains
Andrographis Paniculata, filter residue are spare；
S13. the philippine flemingia root for taking formula ratio, with the extraction of 80% alcohol reflux 2 times of 8 times of philippine flemingia root quality amount volumes, every time
3h, combined extract, filtrate are concentrated and dried into dry cream, and 4L is diluted and be settled to 80% ethyl alcohol, and above-mentioned solution flings to ethyl alcohol, use
The water of 10 times of amounts dilutes, and macroporous resin column on aqueous, resin column dosage is 6 times of water dilute solution volume, is first drenched with water
It washes, the dosage of water is 6 times of water dilute solution, and in 10ml/min, then with 60% ethanol elution, flow control exists flow control
10ml/min, it is colourless to be eluted to eluent, collects ethanol eluate, filtration, relative density is 1.08 when filtrate is concentrated into 80 DEG C
~1.12 clear cream obtains philippine flemingia root alcohol extract；
S14. leatherleaf mahonia, the single side needle for taking formula ratio in proportion are decocted 2 times with water, and water consumption is two taste Chinese medicine total weights
10 times of amounts, decocting time is 3 hours, and collecting decoction, filtration, relative density is 1.08~1.12 when filtrate is concentrated into 80 DEG C
Clear cream obtains leatherleaf mahonia, single side needle water extract；
S15. cherokee rose root, Caulis Spatholobi, the Radix Codonopsis for taking formula ratio in proportion are decocted 2 times with water, and for the first time plus three taste Chinese medicines are total
The water of 10 times of weight amounts, the dregs of a decoction after extracting for the first time add the resulting Herba Andrographitis dregs of a decoction of S12 to decoct together 2 hours, and amount of water is
10 times of amounts of four taste Chinese medicine total weights, collecting decoction, filtration, filtrate merge concentration, obtain cherokee rose root, Caulis Spatholobi, Radix Codonopsis water extract；
S16. above-mentioned five kinds of extracts mixed in proportion, be watered dissolution, make the water content 35% of extract to get in
Drug composition extract.
S2. the preparation of hand cleanser, it is described preparation the following steps are included:
S21. lauryl sodium sulfate, deionized water are proportionally added into, are heated to 80 DEG C, stir evenly, until completely mixed
It is molten；
S22. lauroyl propylhomoserin sodium, Cocoamidopropyl betaine are proportionally added into S21 products therefrom, at a slow speed
It stirring evenly, stops heating, placement is cooled to 50 DEG C, it is proportionally added into Chinese medicine composition extract, the potassium sorbate of S1 preparation,
It stirs to clarify；
S23. citric acid is dissolved in deionized water, is configured to the citric acid that mass concentration is 40%, to be produced obtained by S22
After object is cooling, citric acid is added by formula rate, is stirring evenly and then adding into glycerol, after sufficiently being dissolved to all substances,
Essential oil is added dropwise, stirs evenly at a slow speed to get hand cleanser of the present invention.
A kind of hand cleanser and preparation method thereof of the natural bacteriostatic anti-inflammatory of embodiment 4
(1) it is formulated: including following mass component: 8 parts of Chinese medicine composition extract, lauryl sodium sulfate 10 in raw material
Part, 60 parts of deionized water, 5 parts of lauroyl propylhomoserin sodium, 8 parts of Cocoamidopropyl betaine, 1 part of potassium sorbate, citric acid 3
Part, 4.9 parts of glycerol, 0.1 part of essential oil；The mass parts of each ingredient in the Chinese medicine composition extract are as follows: angelica extract 9
Part, 9 parts of Herba Andrographitis alcohol extract, 12 parts of philippine flemingia root alcohol extract, leatherleaf mahonia, 30 parts of single side needle water extract, cherokee rose root, Caulis Spatholobi, party
40 parts of water extract of ginseng；In the leatherleaf mahonia, single side needle water extract, the mass ratio of leatherleaf mahonia and single side needle is 18:10, the gold cherry
Root, Caulis Spatholobi, in Radix Codonopsis water extract, the mass ratio of each ingredient is 18:14:8, and the citric acid is after deionized water dissolving is added
Citric acid.
(2) preparation method: with embodiment 1
A kind of hand cleanser and preparation method thereof of the natural bacteriostatic anti-inflammatory of embodiment 5
(1) it is formulated: including following mass component: 2 parts of Chinese medicine composition extract, lauryl sodium sulfate 5.8 in raw material
Part, 75 parts of deionized water, 8 parts of lauroyl propylhomoserin sodium, 5 parts of Cocoamidopropyl betaine, 1 part of potassium sorbate, citric acid 1
Part, 2 parts of glycerol, 0.2 part of essential oil；The mass parts of each ingredient in the Chinese medicine composition extract are as follows: angelica extract 9
Part, 9 parts of Herba Andrographitis alcohol extract, 12 parts of philippine flemingia root alcohol extract, leatherleaf mahonia, 20 parts of single side needle water extract, cherokee rose root, Caulis Spatholobi, party
50 parts of water extract of ginseng；In the leatherleaf mahonia, single side needle water extract, the mass ratio of leatherleaf mahonia and single side needle is 15:9, the gold cherry
Root, Caulis Spatholobi, in Radix Codonopsis water extract, the mass ratio of each ingredient is 15:15:9, and the citric acid is after deionized water dissolving is added
Citric acid.
(2) preparation method: with embodiment 1.
A kind of hand cleanser and preparation method thereof of the natural bacteriostatic anti-inflammatory of embodiment 6
(1) be formulated: in raw material include following mass component: 8 parts of Chinese medicine composition extract, 5 parts of lauryl sodium sulfate,
65 parts of deionized water, 5 parts of lauroyl propylhomoserin sodium, 5 parts of Cocoamidopropyl betaine, 2.7 parts of potassium sorbate, 3 parts of citric acid,
6 parts of glycerol, 0.3 part of essential oil；The mass parts of each ingredient in the Chinese medicine composition extract are as follows: 9 parts of angelica extract, wear
10 parts of heart lotus alcohol extract, 11 parts of philippine flemingia root alcohol extract, leatherleaf mahonia, 30 parts of single side needle water extract, cherokee rose root, Caulis Spatholobi, Radix Codonopsis water
40 parts of extract；In the leatherleaf mahonia, single side needle water extract, the mass ratio of leatherleaf mahonia and single side needle is 17:8, the cherokee rose root, chicken
In blood rattan, Radix Codonopsis water extract, the mass ratio of each ingredient is 17:16:9, and the citric acid is the lemon being added after deionized water dissolving
Lemon acid.
(2) preparation method: with embodiment 1.
A kind of hand cleanser and preparation method thereof of the natural bacteriostatic anti-inflammatory of embodiment 7
(1) be formulated: in raw material include following mass component: 4 parts of Chinese medicine composition extract, 6 parts of lauryl sodium sulfate,
70 parts of deionized water, 6 parts of lauroyl propylhomoserin sodium, 6 parts of Cocoamidopropyl betaine, 1.5 parts of potassium sorbate, 1 part of citric acid,
5 parts of glycerol, 0.5 part of essential oil；The mass parts of each ingredient in the Chinese medicine composition extract are as follows: 10 parts of angelica extract,
9 parts of Herba Andrographitis alcohol extract, 12 parts of philippine flemingia root alcohol extract, leatherleaf mahonia, 24 parts of single side needle water extract, cherokee rose root, Caulis Spatholobi, Radix Codonopsis water
45 parts of extract；In the leatherleaf mahonia, single side needle water extract, the mass ratio of leatherleaf mahonia and single side needle is 14:8, the cherokee rose root, chicken
In blood rattan, Radix Codonopsis water extract, the mass ratio of each ingredient is 14:14:10, and the citric acid is the lemon being added after deionized water dissolving
Lemon acid.
(2) preparation method: with embodiment 1.
A kind of hand cleanser and preparation method thereof of the natural bacteriostatic anti-inflammatory of embodiment 8
(1) be formulated: in raw material include following mass component: 4 parts of Chinese medicine composition extract, 6 parts of lauryl sodium sulfate,
70 parts of deionized water, 6 parts of lauroyl propylhomoserin sodium, 6 parts of Cocoamidopropyl betaine, 1.5 parts of potassium sorbate, 2 parts of citric acid,
4 parts of glycerol, 0.5 part of essential oil；The mass parts of each ingredient in the Chinese medicine composition extract are as follows: 9 parts of angelica extract, wear
9 parts of heart lotus alcohol extract, 10 parts of philippine flemingia root alcohol extract, leatherleaf mahonia, 25 parts of single side needle water extract, cherokee rose root, Caulis Spatholobi, Radix Codonopsis water mention
47 parts of object；In the leatherleaf mahonia, single side needle water extract, the mass ratio of leatherleaf mahonia and single side needle is 16:9, the cherokee rose root, chicken blood
In rattan, Radix Codonopsis water extract, the mass ratio of each ingredient is 16:16:9, and the citric acid is the lemon being added after deionized water dissolving
Acid；The angelica extract, Herba Andrographitis alcohol extract, philippine flemingia root alcohol extracting are purchase commercial product, the leatherleaf mahonia, single side needle
Water extraction is the commercially available leatherleaf mahonia water extract of purchase, single side needle water extract, then is deployed in proportion, the cherokee rose root, Caulis Spatholobi,
Radix Codonopsis water extract is that the commercially available cherokee rose root water extract of purchase, Aqueous Extracts From Caulis Spatholobi, Radix Codonopsis water extract deploy in proportion again.
(2) preparation method:
S1. the preparation of Chinese medicine composition extract, it is described preparation the following steps are included:
S11. leatherleaf mahonia water extract, single side needle water extract are chosen in proportion, are deployed into leatherleaf mahonia, single side needle mixing water mentions
Object, it is spare；
S12. cherokee rose root water extract, Aqueous Extracts From Caulis Spatholobi, Radix Codonopsis water extract are chosen in proportion, are deployed into cherokee rose root, chicken blood
Rattan, Radix Codonopsis mixing water extract, it is spare；
S13. the water extract that will be deployed in S11 and S12, in proportion with angelica extract, Herba Andrographitis alcohol extract, philippine flemingia root alcohol
Extract allotment, is made Chinese medicine composition extract, makes its water content 30%.
S2. the preparation method of hand cleanser: with embodiment 1
The experiment of 9 microbiological indicator of experimental example
Microbial indicators detected is carried out to the hand cleanser that the preparation method of Examples 1 to 8 obtains, according to the country of hand cleanser
Standard GB 19877.1-2005 is measured.It the results are shown in Table 1.
The microorganism detection index number of 1 different experiments group hand cleanser of table
| Total plate count, CFU/g | Excrement colibacillus group | |
| Embodiment 1 | 18 | 0 |
| Embodiment 2 | 17 | 0 |
| Embodiment 3 | 19 | 0 |
| Embodiment 4 | 20 | 0 |
| Embodiment 5 | 19 | 0 |
| Embodiment 6 | 20 | 0 |
| Embodiment 7 | 21 | 0 |
| Embodiment 8 | 48 | 0 |
From above-mentioned table data can be seen that hand cleanser of the present invention microorganism detection content it is extremely low, significantly larger than
The content of microorganisms of national standard, embodiment 8 is slightly above Examples 1 to 7, may be with the original in Chinese medicine composition in embodiment 8
Material is related for purchase commercial product.
The experiment on probation of 10 product effect of experimental example
On December 20th, 2016 sample is deployed according to the method for the embodiment of the present invention 1, embodiment 4, embodiment 8, is in addition purchased
A hand cleanser fast-selling on the market group as a comparison case is bought, fragrance is carried out to experimental group sample, washes rear skin comfort degree progress
Grope to test.Select 100 consumers as evaluating member form evaluation group, it is desirable that evaluating member before evaluation hand without by
To hurt, without decortication situation, collection evaluation form is for statistical analysis, it as a result see the table below 2:
The fragrance of 2 different experiments group hand cleanser of table and wash rear Comfort Evaluation
User's result on trial shows: hand cleanser products pleasant aroma of the present invention, washes rear skin comfort, and effect is better than comparative example
Group.
11 skin irritation test of experimental example
By taking hand cleanser prepared by the method for Examples 1 to 8 as an example, observation hand cleanser is anti-to the irritation and anaphylaxis of skin
It answers, provides reference to evaluate its safety.
(1) skin irritation test is carried out using rabbit, divides intact skin group and damage skin group, for 24 hours by rabbit before test
Back backbone diamond wool shaves off, and is kept in contact respectively with hand cleanser prepared by the embodiment of the present invention 1~8 with rabbit skin and mucosa
After 1d, continuous 7d, whether there is or not the stimulate the reactions such as erythema, oedema for observation skin.
(2) skin allergy experiment is carried out using cavy, weekly the hand cleanser with the preparation of the embodiment of the present invention 1~8 and cavy
Skin and mucosa is kept in contact 2 times, contacts 4h or more every time, continuous 3 weeks, whether there is or not the allergic reactions such as erythema, oedema for observation skin.
Experimental result:
The intact skin and damaged skin of rabbit, remove after being intended for single use or be used for multiple times for 24 hours, respectively at 1,24,48,
72h observation, is showed no erythema and oedema, and stimulate the reaction mean scores are < 0.5, nonirritant.
In guinea pig skin allergic experiment, does not occur the cutaneous anaphylaxises such as the obvious erythema of skin, oedema and other are systemic
Allergic reaction.
Therefore, inhibiting bacteria and diminishing inflammation hand cleanser of the invention will not cause irritation anti-rabbit intact skin and damage skin
It answers, to guinea pig skin without allergic reaction, there is good cutaneous safety.
12 bacteriostatic experiment of experimental example
In Vitro Bacteriostasis examination is carried out to the hand cleanser and commercially available common hand cleanser (control group) of the method preparation of Examples 1 to 8
It tests.
1. materials and methods
The 0.03mol/L phosphate buffer (PBS) of the preparation of 1.1 bacteria suspensions peptone containing 10g/L, by golden yellow Portugal
Fresh cultured object inclined-plane lawn is washed down for 24 hours for grape coccus (ATCC6538), Escherichia coli (8099), Pseudomonas aeruginosa (ATCC9027),
Bacteria suspension is made into PBS dilution again.
1.2 bacteriostatic tests choose inhibiting bacteria and diminishing inflammation hand cleanser ingredient (8 groups of example 1 group~embodiment) of the present invention, it is commercially available not
Hand cleanser (control group) containing antipathogenic composition.Qualitative filter paper is made to the disk of diameter 5mm, after pressuresteam sterilization is handled,
120 DEG C of dry 2h are set, it is spare.It takes the filter paper handled well to be put into sterilized petri dishes (4 one folded), about 20 μ l is added dropwise respectively and respectively wash
Hand liquid stoste is to filter paper, and as test print, negative control print is added dropwise 20 μ l sterile distilled waters, dries spare.With sterile
Cotton swab dips above-mentioned test bacteria suspension and is uniformly applied to nutrient agar planar surface respectively, sets drying at room temperature 5min.
Test print is placed on microbiological contamination plate, each plate is placed with 4 test prints and 1 negative control print totally 5.Each print
At a distance of 25mm or more between center, the periphery with plate tests 1 plate at a distance of 15mm or more every time.After being placed with, 37 DEG C are set
Incubator 16~18h of culture, observation is as a result, measure the diameter (including patch) of antibacterial ring size, and record measurement data.Experiment repeats 3
It is secondary.Inhibition zone diameter > 7mm person has been judged to bacteriostasis, and≤7mm person is judged to no bacteriostasis, and 3 repetition tests, which reach, suppression
Bacterium exercising result person, is judged to qualification.Negative control group should be generated without antibacterial ring size, and otherwise test is invalid.
2 results
2.1 bacteriostatic tests are from bacteriostatic test result (table 3) as can be seen that hand cleanser stoste example 1 group~reality of the present invention
Applying 8 groups of example has certain inhibiting effect to Escherichia coli, staphylococcus aureus and Pseudomonas aeruginosa, and wherein example 1 group is washed
Hand liquid fungistatic effect is best, and 8 groups of hand cleanser fungistatic effects of embodiment are poor, and control group hand cleanser to 3 kinds of bacteriums without antibacterial effect
Fruit.
Bacteriostatic diameter (mm) of the 3 different experiments group hand cleanser of table to different bacterium
The result shows that: the hand cleanser of the embodiment of the present invention 1~8 has preferable bacteriostatic activity, (commercially available better than control group
Common hand cleanser).
13 application experiment of experimental example
Using the inhibiting bacteria and diminishing inflammation hand cleanser of embodiment 1,4,8 as experimental material, as a control group with commercially available common hand cleanser, choosing
Selecting hand has adult totally 200 people, the age-based layer of slight wound to be randomly divided into 4 groups, and every group of 50 people are cleaned 5 times with swab stick daily,
After 3 days, detects inhibiting bacteria and diminishing inflammation hand cleanser provided by the invention and unite to the anti-inflammatory situation of wound, and to its experimental result
Meter.It the results are shown in Table 4.
Anti-inflammatory situation of the 4 different experiments group hand cleanser of table to wound location
As the result is shown: having 15 in control group using there is stimulate the reaction after the product of control group, and wound is occurred
Stimulation do not occur for phenomenon of festering (account for total number of persons 30%), embodiment 1, embodiment 4 and wound festers reaction in embodiment 8.
As it can be seen that inhibiting bacteria and diminishing inflammation hand cleanser provided by the invention to wound skin without any irritation and side effect, and have anti-inflammatory effects.
Detailed process equipment and processing step of the invention that the present invention is explained by the above embodiments, those skilled in the art
Member is not it should be appreciated that the present invention is limited by above-described embodiment, and the above embodiments and description only describe the present invention
Principle, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, this is to this field
It is it will be apparent that these changes and improvements all fall within the protetion scope of the claimed invention for technical staff.
Claims (10)
1. a kind of natural bacteriostatic anti-inflammatory hand cleanser, which is characterized in that the hand cleanser is by Chinese medicine composition extract and dodecane
Base sodium sulphate, deionized water, lauroyl propylhomoserin sodium, Cocoamidopropyl betaine, potassium sorbate, citric acid, glycerol, draft
Essence is raw material, is aided with suitable auxiliary material and is prepared；Include following component in the Chinese medicine composition extract: Radix Angelicae Sinensis extracts
Object, Herba Andrographitis alcohol extract, philippine flemingia root alcohol extract, leatherleaf mahonia, single side needle water extract, cherokee rose root, Caulis Spatholobi, Radix Codonopsis water extract.
2. hand cleanser according to claim 1, which is characterized in that the hand cleanser includes the raw material of following mass parts: in
2~8 parts of drug composition extract, 5~10 parts of lauryl sodium sulfate, 60~75 parts of deionized water, lauroyl propylhomoserin sodium 5~
10 parts, 5~10 parts of Cocoamidopropyl betaine, 1~2 part of potassium sorbate, 1~5 part of citric acid, 2~6 parts of glycerol, draft perfume
0.1~0.5 part of essence.
3. hand cleanser according to claim 2, which is characterized in that the hand cleanser includes the raw material of following mass parts: in
2~6 parts of drug composition extract, 5~8 parts of lauryl sodium sulfate, 60~70 parts of deionized water, lauroyl propylhomoserin sodium 5~8
Part, 5~8 parts of Cocoamidopropyl betaine, 1~2 part of potassium sorbate, 1~3 part of citric acid, 4~5 parts of glycerol, essential oil
0.1~0.5 part.
4. hand cleanser according to claim 2, which is characterized in that the hand cleanser includes the raw material of following mass parts: in
4 parts of drug composition extract, 6 parts of lauryl sodium sulfate, 70 parts of deionized water, 6 parts of lauroyl propylhomoserin sodium, coconut oleoyl amine third
6 parts of base glycine betaine, 1.5 parts of potassium sorbate, 2 parts of citric acid, 4 parts of glycerol, 0.5 part of essential oil.
5. hand cleanser according to any one of claims 1 to 4, which is characterized in that the Chinese medicine composition extract includes such as
The ingredient of lower mass parts: 8~10 parts of angelica extract, 8~10 parts of Herba Andrographitis alcohol extract, 8~12 parts of philippine flemingia root alcohol extract, contribution
Wood, 20~30 parts of single side needle water extract, cherokee rose root, Caulis Spatholobi, 40~50 parts of Radix Codonopsis water extract.
6. hand cleanser according to claim 5, which is characterized in that the Chinese medicine composition extract includes following mass parts
Ingredient: 9 parts of angelica extract；9 parts of Herba Andrographitis alcohol extract, 10 parts of philippine flemingia root alcohol extract, leatherleaf mahonia, single side needle water extract 25
Part, cherokee rose root, Caulis Spatholobi, 47 parts of Radix Codonopsis water extract.
7. hand cleanser according to claim 5, which is characterized in that in the leatherleaf mahonia, single side needle water extract, each ingredient
Mass ratio are as follows: 14~18:8~10, the cherokee rose root, Caulis Spatholobi, Radix Codonopsis water extract in, the mass ratio of each ingredient are as follows: 14~18:
14~18:8~10.
8. hand cleanser according to claim 5, which is characterized in that in the leatherleaf mahonia, single side needle water extract, each ingredient
Mass ratio is 16:9, the cherokee rose root, Caulis Spatholobi, Radix Codonopsis water extract in, the mass ratio of each ingredient are as follows: 16:16:9.
9. according to claim 1~4,6~8 any hand cleanser, which is characterized in that the citric acid is that deionization is added
The dissolved citric acid of water, the mass concentration of the citric acid are 20~40%；The mass concentration of the citric acid is preferably 30%.
10. according to claim 1~4,6~8 any hand cleanser, which is characterized in that the preparation method of the hand cleanser
The following steps are included:
S1. the preparation of Chinese medicine composition extract, it is described preparation the following steps are included:
S11. the Radix Angelicae Sinensis for taking formula ratio, 75% ethyl alcohol for measuring volume with 0.5 times of its quality extract, and extraction temperature is 35~38 DEG C,
Extracting pressure is 20Mpa, and parsing pressure is 8Mpa, CO2Flow is 8L/h, and extraction time is 2~4h, collect extract to get
The angelica extract；
S12. the Herba Andrographitis for taking formula ratio is extracted with 70~85% alcohol reflux, recycles ethyl alcohol, and filtrate is condensed into clear cream, must wear
Heart lotus extract, filter residue are spare；
S13. the philippine flemingia root for taking formula ratio, with the extraction of 65~80% alcohol refluxs 2 times of 6~8 times of philippine flemingia root quality amount volumes, often
Secondary 1~3h, combined extract, filtrate are concentrated and dried into dry cream, and 2~4L, above-mentioned solution are diluted and be settled to 65~80% ethyl alcohol
Ethyl alcohol is flung to, the water measured with 6~10 times dilutes, macroporous resin column on aqueous, and resin column dosage is water dilute solution volume
4~6 times, first eluted with water, the dosage of water is 4~6 times of water dilute solution, and flow control is in 6~10ml/min, then with 60%
Ethanol elution, for flow control in 6~10ml/min, it is colourless to be eluted to eluent, collects ethanol eluate, filtration, filtrate concentration
The clear cream that relative density is 1.08~1.12 when to 80 DEG C, obtains philippine flemingia root alcohol extract；
S14. leatherleaf mahonia, the single side needle for taking formula ratio in proportion, with water decoct 2 times, water consumption be two taste Chinese medicine total weights 8~
10 times of amounts, decocting time are 2~3 hours, and collecting decoction, filtration, relative density is 1.08~1.12 when filtrate is concentrated into 80 DEG C
Clear cream, obtain leatherleaf mahonia, single side needle water extract；
S15. cherokee rose root, Caulis Spatholobi, the Radix Codonopsis for taking formula ratio in proportion are decocted 2 times with water, add three taste Chinese medicine total weights for the first time
The water of 4~10 times of amounts, the dregs of a decoction after extracting for the first time add the resulting Herba Andrographitis dregs of a decoction of S12 to decoct together 2 hours, amount of water four
4~10 times of amounts of taste Chinese medicine total weight, collecting decoction, filtration, filtrate merge concentration, obtain cherokee rose root, Caulis Spatholobi, Radix Codonopsis water and mention
Object；
S16. above-mentioned five kinds of extracts mixed in proportion, be watered dissolution, make the water content 20~35% of extract to get in
Drug composition extract；
S2. the preparation of hand cleanser, it is described preparation the following steps are included:
S21. lauryl sodium sulfate, deionized water are proportionally added into, are heated to 60~80 DEG C, stir evenly, until completely mixed
It is molten；
S22. lauroyl propylhomoserin sodium, Cocoamidopropyl betaine are proportionally added into S21 products therefrom, are mixed slowly
Uniformly, stop heating, placement is cooled to 40~50 DEG C, is proportionally added into Chinese medicine composition extract, the potassium sorbate of S1 preparation
It stirs to clarify；
S23. citric acid is dissolved in deionized water, is configured to the citric acid that mass concentration is 20~40%, to be produced obtained by S22
After object is cooling, citric acid is added by formula rate, is stirring evenly and then adding into glycerol, after sufficiently being dissolved to all substances,
Essential oil is added dropwise, stirs evenly at a slow speed to get hand cleanser of the present invention.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111150695A (en) * | 2020-01-14 | 2020-05-15 | 浙江神英科技股份有限公司 | Preparation method of hand sanitizer with super-strong decontamination effect |
| CN113318021A (en) * | 2021-05-26 | 2021-08-31 | 建昌帮药业有限公司 | Hand sanitizer |
-
2017
- 2017-12-20 CN CN201711382894.5A patent/CN109939030A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111150695A (en) * | 2020-01-14 | 2020-05-15 | 浙江神英科技股份有限公司 | Preparation method of hand sanitizer with super-strong decontamination effect |
| CN113318021A (en) * | 2021-05-26 | 2021-08-31 | 建昌帮药业有限公司 | Hand sanitizer |
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