CN1765369A - Nano silver gel and its application - Google Patents

Abstract

The invention relates to a nano-silver gel, which comprises a nano-silver solution and a hydrogel. The nano-silver gel can be used for treating female lower genital tract inflammation, cervicitis or skin injury areas.

Description

Nano silver gel and its application

technical field

The invention relates to a nano-silver gel, which comprises a nano-silver solution and a hydrogel. The nano-silver gel of the invention can be used to treat women's lower reproductive tract inflammation, cervicitis or skin injury area.

Background technique

Silver has a recognized antibacterial effect. It kills various microorganisms by blocking the oxygen transport activity of bacterial cell walls and inhibiting bacterial DNA replication. Generally speaking, an antibiotic can kill roughly 6 different kinds of organisms, but silver can kill more than 600 kinds of bacteria. In addition, silver is a non-toxic substance, so silver has a wide range of uses and a long history. Through high-tech nanotechnology, the activity of silver particles is enlarged, the antibacterial function is enhanced, and the quality of home environment and personal hygiene is significantly improved. Both nano-scale fine particles of silver and the aqueous solution of silver ions released by nano-silver have significant bactericidal effects. In the case of multiple dilutions, nano-silver has 99.99% inhibitory effect on Escherichia coli, Staphylococcus aureus, Salmonella and Pseudomonas aeruginosa, which is mainly due to the biological effect of silver itself.

Active silver ions can attract sulfhydryl groups on the enzyme proteins in bacteria, quickly combine them together, and inactivate the enzymes containing sulfhydryl groups, resulting in the death of bacteria. It is worth noting that when the bacteria are killed by silver ions, the silver ions will be freed from the dead bacteria, and then continue to repeat the action on the live bacteria until all the bacteria are eliminated. It can be seen that the effect of nano-silver is a long-acting antibacterial agent with a long-lasting effect. Nano-silver uses the small size effect and surface effect of nano-materials to further improve the bactericidal power of silver. As far as the bactericidal mechanism of silver ions is concerned, silver ions can destroy bacterial cell membranes at very low concentrations; or they can strongly attract the sulfhydryl group of protein B in bacteria and quickly combine with it to reduce the enzyme activity of bacterial protozoa, thereby producing Antibacterial effect; at the same time, through the slow release of silver ions, it can exert a long-lasting antibacterial effect.

Vaginitis and cervicitis are female lower genital tract inflammations with a higher incidence rate, which have a great impact on the physical and mental health of women and their family members. Although there are many therapeutic products in the market, they are not ideal in terms of dosage forms, methods of use, and curative effects.

Vaginal inflammation is caused by bacteria, molds, chlamydia, mycoplasma, viruses, protozoa, etc. The source of vaginal infection can ascend to the uterine cavity, fallopian tubes, ovaries and pelvic cavity, resulting in acute and chronic endometritis, salpingitis, oophoritis or pelvic inflammatory disease. In addition to inflammation symptoms, chronic infection can even cause intestinal obstruction and infertility.

Contents of the invention

The invention provides a nano-silver gel, preferably comprising a nano-silver solution and a hydrogel at a concentration of 2 to 100 ppm, wherein the nano-silver solution and the hydrogel are uniformly mixed at a weight ratio of 1:20 to 20:1.

In the nano silver gel of the present invention, the concentration of the nano silver solution is 2 to 100 ppm, the preferred concentration is 10 to 50 ppm, and the most preferred concentration is 20 ppm.

In the nano silver gel of the present invention, the weight ratio of the nano silver solution to the hydrogel is 1:20 to 20:1, preferably 1:10 to 10:1, most preferably 9:1.

In the nano silver gel of the present invention, the gel is cellulose derivative (methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose or hydroxyethyl cellulose), acrylate polymer, acrylate derivative substances, alginic acid and xanthan gum.

The nano-silver gel of the present invention uses a push-pull sleeve gel device to transfer the nano-silver gel, and the shape of the gel device to transfer the nano-silver gel is round.

Nano-silver gel of the present invention is used for the application of processing various infections by various routes of administration, and it can treat women's lower reproductive tract inflammation (candida vaginitis, bacterial vaginitis, trichomonas vaginitis, senile vaginitis or vaginal Mixed infection) or cervicitis (chronic cervicitis or cervical erosion), for skin injury areas (skin inflammation, skin trauma or burns, where skin inflammation is tinea pedis, jock itch, acne or acne causing skin inflammation) .

Various pharmaceutical additives are added to the nano silver gel of the present invention to make a delivery dosage form, which can be processed including promoting skin growth (adding epidermal growth-stimulating hormone), preventing scar generation (adding anti-scarring ingredients such as bismuth hypogallate or natural plant extracts) ), treatment of skin inflammation, skin trauma burns (add aloe extract).

Description of drawings

Fig. 1 is the gel device for administering nano-silver gel to the diseased part.

Fig. 2 is the combination situation of the pusher of the gel device and the gel device barrel for administering the nano-silver gel to the diseased part.

Icons represent symbol descriptions:

10 gels

20 gel cartridges

30 push cylinder

40 elastic plug

50 exits

60 tight cover

70nm silver gel

Detailed ways

The present invention provides nano-silver mixed with a hydrogel formed by polymer cross-linking. The preparation technology and preparation ratio are as follows, using nano-silver particles purchased by the manufacturer with bactericidal and fungicidal capabilities, which have been disclosed in US 2002051823. Compositions with nanosilver particles smaller than 100 nm have been disclosed in WO 03080231. Add sterilized water to prepare a 20ppm nano silver solution. Tegagel ^(TM) hydrogels were then purchased from the manufacturer 3M. The nano-silver gel of the present invention was prepared by 20 ppm nano-silver solution and hydrogel in a weight ratio of 9:1.

Other commercially available gels that can replace Tegagel and are included in the present invention are listed in the table below: manufacturer product name manufacturer product name 3M Tegagel Hollister Inc. restore Amerx Health Care Amerigel Topical Ointment Johnson & Johnson NU-GEL Bard Medical Bard Absorption Dressing Biolex, Iamin Kendall CURAFIL Carrington Laboratories CarraSorb, CarrasynDIAB GEL Medline Skin Tegrity Coloplast Woun' Dres Purilon Molnlycke HealthCare Hypergel Normlgel ConvaTec DuoDERMSAF-Gel MPM Medical, Inc. MPM DermaRite DermaSyn ProCyte Iamin Health Point CURASOL Sage Laboratories PanoPlex Derma Sciences, Inc. Dermagran

The invention provides the administration route of the nano silver gel in treating various infections. Before antibiotics were widely used, people had discovered that silver had antibacterial effects and was used to kill bacteria, mainly because microorganisms would develop resistance to antibiotics, but not to silver. The nano-silver used in the present invention can be applied to hygienic products, including but not limited to clothes cleaners, cleaners for women's acne and pimples, soaking solution for toothpaste, and the like. At the same time, it can also be applied to health and medical products, including but not limited to wounds or burns, bacterial or fungal infections (including gynecological infections such as vaginitis), gastrointestinal bacterial infections, and sexually transmitted diseases of patients. In addition, the nano-silver solution can also be applied to industrial products, including but not limited to the preservation of food, especially fruits and vegetables, disinfectant for drinking water, preservation of paper and engineering fillings (especially to prevent the generation of mold).

The nano-silver composition used in the present invention has broad-spectrum bactericidal and fungicidal capabilities, which can kill and prevent the proliferation of bacteria or mold. These bacteria or molds include Escherichia coli (Escherichiacoli), Methicilli71-resistant Staphylococcus aureus, Chlamydia trachomatis, Providenciastuartii, Vibrio vulnificus, pneumonia Pneumobacillus, nitrate-negative bacillus (bacillus), Staphylococcus aureus, Candida albicans, Bacillus cloacae, Bacillus allantoides, Morgan's bacillus ( Salmonella naorgani), Pseudomonasmaltophila, Pseudomonas aeruginosa, Neisseriagonorrhoeae, Bacillus subtilis, Bacillus foecalisalkaligenes, Streptococcus hemolyicus B, lemon Citrobacter, and Salmonella paratyphi C.

Compared with traditional antibiotics, the antibacterial and antifungal properties of the nano silver composition used in the present invention has the advantage of not causing drug-resistant bacteria or molds.

gel

The gel used in the present invention is from 3M Tegagel ^™ Wound Hydrogel. The hydrogel is formed by cross-linking polymers, which has the advantage of being a clear and transparent hydrogel, which can help moisturize the wound treatment and is non-irritating. Because Tegagel has 95% water, it can effectively reduce the pain of nerve endings in the wound, and it is in the form of a gel, which is easy to use.

The gel used in the present invention is optimally used to provide and maintain a moist recovery environment. Due to the increased humidity around the affected area, the gel can assist in cleansing and removal of dead tissue or bacteria. The gel can also be used on wounds or burns. Another advantage of the gel is that it does not cause damage to the site when it is removed, and its soft touch improves patient compliance.

Route of administration

The administration route of the present invention is preferably external application in the form of solution, emulsion or ointment. The present invention can be applied to skin, wound, eyes, nose or mouth to prevent and treat various infections. The compositions of the present invention can be applied by known methods, one of which is gloved hand application. Other special wound treatment methods can also be applied to the affected area together. The present invention provides long-lasting antimicrobial efficacy.

When the compositions of the present invention are used to treat ocular infections, the compositions of the present invention can be applied to the lower eyelid in a standard manner as a solution or ointment, or the composition can be formulated as eye drops and applied to the eye in a standard manner. department.

When the composition of the present invention is used to treat inflammation of the mouth, including gingivitis, the composition of the present invention can be applied in the form of a solution or ointment, in a manner similar to a sponge or toothpaste. The composition may also be injected into a cavity in the body in the form of a solution to treat infections.

The compositions of the present invention have several advantages when administered topically. First, the present invention does not contain any antibiotics that may make patients uncomfortable. Secondly, the present invention will not cause bacteria or molds to develop drug resistance. In addition, nanosilver does not stain the patient's skin or clothing, unlike other metal particles.

The composition of the present invention can additionally add other common pharmaceutical additives, such as epidermal growth-stimulating factor (EGF). Epidermal growth-stimulating hormone is an important auxin, which is a peptide chain composed of 50-60 amino acid molecules, and the chain contains 6 cysteine molecules. Stable disulfide bonds are formed between cysteine molecules, making the entire peptide chain an active substance with three ring-connected parts. Epidermal growth-stimulating hormone can promote the growth and reproduction of epidermal cells, accelerate the repair of injured epidermal cells, inhibit gastric acid secretion, and has a wide range of uses in medicine. Epidermal growth-stimulating hormone can promote the growth of human skin epithelial cells, corneal epithelial cells and mammalian epithelial cells in tissue culture. Epidermal growth-stimulating hormone is also often used in cosmetics, which can promote the growth and reproduction of skin tissue, corneal epithelial tissue and gastric epithelial cells, accelerate the repair of corneal trauma, and enhance the protein and RNA synthesis and cell metabolism of epidermal cells.

Example

The preparation method of embodiment 1 nanometer silver gel

Nano-silver particles were purchased from the manufacturer, and sterilized water was added to prepare a 20ppm nano-silver solution. Tegagel ^(TM) hydrogels were then purchased from the manufacturer 3M. The nano silver gel 70 of the present invention was prepared by 20 ppm nano silver solution and hydrogel at a weight ratio of 9:1. After the nano-silver gel 70 is filled into the gel device 10, the contact end of the gel device cylinder body 20 and the push cylinder 30 is tightly sealed with the elastic plug 40, and the outlet 50 of the gel device cylinder body 20 is tightly sealed with the sealing cover 60, When in use, push the pusher 30 to push the elastic plug 40 to allow the gel to be sent from the outlet 50 to the diseased part of the patient.

Embodiment two nano-silver gel treatment vaginitis and cervicitis

From August 2003 to January 2004, the obstetrics and gynecology department of the hospital used nano-silver antibacterial gel for external use for women to treat various vaginitis and cervicitis.

1. Materials and methods

Patient source:

From August 2002 to January 2004, there were 92 patients with lower genital tract inflammation, including 47 cases of vaginitis and 3 cases of mixed infection. The age of the patients ranged from 18 to 51 years old, with an average of 31.2 years old.

2. Test material

The prepared nano-silver gel of embodiment one.

3. Diagnostic criteria

Vaginitis is diagnosed based on clinical manifestations and pathogenic bacteria examination; cervical erosion is divided into mild, moderate and severe according to the area of erosion according to "Chinese Obstetrics and Gynecology" edited by Cao Zeyi, and divided into simple type, granular type and mastoid according to the surface of erosion type.

4. Treatment

After cleaning the lower part of the vagina before going to bed every night, the patient pushes the antibacterial gel into the deep part of the vagina with a gel applicator (see Figure 1), taking 1 stick every night for 6 consecutive days. Patients with vaginitis will be re-examined 3 days after treatment, and patients with cervicitis will be re-examined 7 days after treatment. Inquire about the improvement of the patient's subjective symptoms, reexamine the congestion of the vagina and cervix, and conduct corresponding experiments and inspections on the secretions.

5. Curative effect evaluation standard

(a) Vaginitis (including candidal vaginitis and trichomonas vaginitis)

Recovery: Symptoms and signs disappear, leucorrhea decreases, and leucorrhea laboratory tests are negative;

Significantly effective: the symptoms and signs have improved significantly, but have not completely disappeared, and the leucorrhea laboratory test is negative;

Take a turn for the better: symptoms and signs alleviate, leucorrhea lab test is positive (do invalid statistics);

Ineffective: no improvement in symptoms and signs, and the leucorrhea laboratory test was positive.

(b) bacterial vaginosis

Recovery: symptoms and signs disappeared, vaginal secretion pH <4.5, amine test was negative, no clue cells were seen;

Significantly effective: the symptoms and signs are obviously improved but not completely disappeared, the pH value of the vaginal secretion is <4.5 or the amine test is negative, and no clue cells are seen;

Improvement: Symptoms and signs have been relieved, vaginal secretion pH value <4.5 or amine test is negative, and clue cells are found (invalid statistics);

Ineffective: There was no significant improvement in symptoms, signs, and laboratory examinations of vaginal secretions.

Effective rate calculation of vaginal inflammation: effective rate=(cured+marked effect)/number of treated cases×100%.

(c) cervical erosion

Recovery: Symptoms and signs disappear, the erosion surface disappears, and the cervix is smooth;

Significantly effective: the symptoms and signs have improved significantly, but have not completely disappeared, the erosion area has shrunk by 1/2, and the severe has turned into moderate, and the moderate has turned into mild;

Effective: Symptoms and signs have improved, but have not completely disappeared, and the erosion area has shrunk by <1/2, or the mastoid type has transformed into a granular type, and the granular type has transformed into a simple type;

Ineffective: no improvement in symptoms and signs, no change in erosion area.

Effective rate=(cured+markedly effective+effective)/number of treated cases×100%.

(d) Adverse reactions

Adverse reactions should be closely monitored during treatment, and adverse reactions that occur should be recorded in detail.

6. Test results

(a) Vaginitis

Of the 47 cases of vaginitis, 38 cases were cured, with a cure rate of 80.9%; 7 cases were markedly effective, with a total effective rate of 95.7%.

Table 1 The effect of nano silver women's topical antibacterial gel in the treatment of vaginitis type Number of cases get well markedly effective get better invalid Efficient(%) Number of cases % Candida vaginitis Bacterial vaginitis Trichomonas vaginitis 201611 16139 80.081.381.8 322 110 000 95.093.8100.0 total 47 38 80.9 7 2 0 95.7

(b) Cervicitis

Among the 42 cases of cervical erosion, 15 cases were mild, with an effective rate of 93.3%; moderate cases, 17 cases, with an effective rate of 82.4%; severe cases, 10 cases, with an effective rate of 80%; the total effective rate was 85.7%, see Table 2 for details.

Table 2 The effect of nano silver women's topical antibacterial gel in the treatment of cervicitis type Number of cases get well markedly effective efficient invalid Efficient(%) Simple mild granular simplex moderate granular simplex severe granular 15011637 1203020 208213 000102 100302 93.3-100.050.0100.071.4 total 42 17 16 3 6 85.7

(c) mixed infection

Among the observed cases, 3 were mixed infections, and 1 of them had bacterial vaginosis, trichomonal vaginitis, and moderate cervical erosion at the same time. After a course of 6 days of treatment, the bacterial vaginosis was markedly effective, the trichomonal vaginitis was cured, and the cervical erosion turned to mild (the curative effect was judged to be markedly effective); 1 case was bacterial vaginosis, candida vaginitis, Patients with severe cervical erosion. After 6 days of treatment, the symptoms improved significantly, the bacterial vaginosis was cured, Candida turned negative, and only hyperemia was seen in the cervix; another patient was infected with Trichomonas vaginalis and Mycoplasma at the same time; after 6 days of treatment with nano-silver gel, Both trichomonas and mycoplasma turned negative.

(d) Adverse reactions

Two patients complained of genital itching, and no abnormalities were found after discontinuation.

7. Discussion

(a) Nano-silver The active ingredient of the antibacterial gel for external use for women, nano-silver, has broad-spectrum antibacterial effects, and can inhibit or kill various pathogens such as bacteria, fungi, and trichomonas. Generally, after using 6 gels, the itching or burning sensation of the vulva is obviously improved, the secretion is reduced, and the peculiar smell disappears. After the treatment, the re-examination has a definite curative effect on various vaginitis. The cure rate is 80.9%, and the total effective rate is 95.7%.

(b) Nano-silver has the effect of promoting tissue repair and regeneration. Nano-silver gel has obvious curative effect on cervicitis, especially on simple cervical erosion caused by infection factors. For cervical erosion caused by other factors, the symptoms are obviously improved after use, cervical congestion is relieved, and secretions are reduced, which is conducive to the second course of treatment or further physical therapy.

(c) A pathogen infection can cause changes in the ecological conditions of the vagina, resulting in a decrease in local defense function and secondary infection by other pathogens. At this time, it is difficult to obtain good curative effect with a single drug treatment. In the study, 3 patients with mixed vaginal infection were treated with nanosilver external antibacterial gel for women alone. After a course of 6 days of treatment, the symptoms of the patients disappeared or improved significantly, and many pathogens were turned negative.

Example 3 Nano silver gel treatment of women's lower reproductive tract inflammation

The obstetrics and gynecology department of the hospital used the nano-silver gel of Example 1 to treat 60 cases of female lower genital tract inflammation from January to March 2004. The curative effects are summarized as follows:

1. Case selection, diagnostic criteria and treatment methods

(a) Case selection:

Randomly select 60 cases of patients with lower reproductive tract inflammation in the outpatient clinic, including 30 cases of cervical erosion and 30 cases of vaginitis (disease). All were newly diagnosed and had never used any drug treatment. They were aged from 22 to 48 years old.

(b) Diagnostic criteria for cervical erosion:

Mild erosion: The erosion surface of the cervix is less than 1/3 of the entire cervix.

Moderate erosion: cervical erosion accounts for 1/2 to 2/3 of the entire cervical area.

Severe erosion: the erosion surface of the cervix is greater than 2/3 of the entire cervix.

According to the depth of the erosion area, it can be divided into: simple type, granular type, and mastoid type.

(c) Diagnostic criteria for vaginitis (disease):

Candida vaginitis: genital itching, increased leucorrhea in the form of bean curd residue or curd, and the leucorrhea is positive for candida in microscopic examination.

Trichomonal vaginitis: genital itching, leucorrhea increased in the form of light yellow foam, leucorrhea microscopic examination of Trichomonas vaginalis was positive.

Bacterial vaginosis: vulvar itching, increased leucorrhea with fishy smell, positive leucorrhea diluent amine test (positive bacterial vaginosis rapid test card).

(d) Treatment:

After cleaning the vulva every night before going to bed, the subjects used the gel applicator (see Figure 1) to push the nano-silver gel into the deep part of the vagina, once a night, and 6 days was a course of treatment. Review 3 to 7 days after treatment, including symptoms, signs and laboratory tests.

2. Efficacy Judgment Criteria

(a) cervical erosion

Recovery: Symptoms and signs disappeared, the erosion surface disappeared, and the cervix was smooth.

Significantly effective: symptoms and signs are significantly relieved, the erosion surface is reduced by 1/2, severe to moderate, and moderate to mild.

Effective: Symptoms and signs are partially alleviated, the erosion surface is reduced by <1/2, or the mastoid type is transformed into a granular type, and the granular type is transformed into a simple type.

Ineffective: no relief of symptoms and signs, no change in the erosion surface.

Effective rate=(cured+markedly effective+effective)/number of treated cases×100%.

(b) Vaginitis (disease)

Recovery from illness: symptoms and signs disappear, leucorrhea decreases and microscopic examination of pathogens (or amine test) is negative.

Significantly effective: symptoms and signs are significantly relieved, leucorrhea is reduced and microscopic examination of pathogens (or amine test) is negative.

Improvement: Symptoms and signs were partially alleviated, and the pathogen (or amine test) of the leucorrhea was positive.

Ineffective: no relief of symptoms and signs, pathogens (or amine test) of leucorrhea are positive.

Effective rate=(cured+marked effect)/number of treated cases×100%.

3. Results

(a) Treatment results for cervical erosion: Among the 30 patients with cervical erosion, 18 were mild, with an effective rate of 94%; 10 were moderate, with an effective rate of 70%; 2 were severe, and 1 was effective. The total effective rate in the treatment of cervical erosion is 83%. See Table 3 for details.

Table 3 The therapeutic effect of nano silver antibacterial gel for women on cervical erosion type Number of cases get well markedly effective efficient invalid Efficient(%) mild moderate severe 18102 700 930 141 131 947050 total 30 7 12 6 5 83

(b) vaginitis (disease) treatment result: among 30 routine vaginitis (disease) patients, 16 cases of candida vaginitis, the effective rate is 88%; 6 cases of trichomonal vaginitis, the effective rate is 100%; 8 cases of vaginitis, the effective rate was 88%. The total effective rate of treating vaginitis (disease) is 90%, see Table 4 for details.

The curative effect of table 4 nanometer silver women's topical antibacterial gel to vaginitis (disease) type Number of cases get well markedly effective get better invalid Efficient(%) Candida vaginitis Trichomonas vaginitis Bacterial vaginosis 1668 1266 201 201 000 8810088 total 30 twenty four 3 3 0 90

Other results: The treatment effect was observed based on the depth of cervical erosion, and the simple type had the best effect; in addition, 5 patients reported a little brown discharge from the vagina during treatment, but no discomfort such as vaginal irritation.

The present invention has been described in detail and illustrated so that those skilled in the art can implement and utilize it. Any substitutions, changes and modifications should be made without departing from the spirit and scope of the present invention.

Those skilled in the art will quickly find that the present invention readily achieves its objectives and obtains the results and advantages described herein. Cell lines, embryos, animals and their manufacturing processes and methods are merely representative of exemplary preferred embodiments, and are not intended to limit the scope of the invention. Modifications and other uses of the present invention will occur to those skilled in the art, and these modifications should be included in the spirit of the present invention and limited only by the scope of the claims.

Those skilled in the art can easily make changes and modifications to the present invention without departing from the spirit and scope of the present invention.

All patents and publications mentioned in this specification are conventional techniques in the field related to the invention. The patents and publications mentioned in this specification are indicative of the level of skill of those familiar with the fields to which the invention pertains.

The drawings of the inventions described herein may operate without any requirements or limitations other than those specifically disclosed herein. The terms and expressions used are used for the purpose of description only, not for limitation, and it is not intended to exclude any equivalents shown and described or parts thereof, and various changes and modifications are considered to be May be within the scope of the invention patent application. Therefore, it should be understood that although preferred embodiments and optional features have been used to specifically disclose the present invention, those skilled in the art may make modifications and changes based on the ideas disclosed therein, and these modifications and changes should be included in the scope of the present invention. within the scope defined in the appended claims.

The following claims refer to other embodiments.

Claims (20)

1. nano silver gel comprises the nanometer silver solution and the hydrogel of concentration 2 to 100ppm, and wherein nanometer silver solution and hydrogel were with 1: 20 to 20: 1 weight ratio uniform mixing.

2. nano silver gel as claimed in claim 1, wherein the concentration of nanometer silver solution is 10 to 50ppm.

3. nano silver gel as claimed in claim 2, wherein the concentration of nanometer silver solution is 20ppm.

4. nano silver gel as claimed in claim 1, wherein the weight ratio of nanometer silver solution and gel is 1: 10 to 10: 1.

5. nano silver gel as claimed in claim 4, wherein the weight ratio of nanometer silver solution and gel is 9: 1.

6. nano silver gel as claimed in claim 1, urogenital tract infection or cervicitis under its treatment women.

7. nano silver gel as claimed in claim 6, wherein urogenital tract infection is candidal vaginitis, antibacterial vaginitis, trichomonal vaginitis, senile vaginitis or vagina mixed infection under the women.

8. nano silver gel as claimed in claim 6, wherein cervicitis is chronic cervicitis or cervical erosion.

9. nano silver gel as claimed in claim 1, it is used for the skin injured area.

10. nano silver gel as claimed in claim 9, wherein the skin injured area is chafing, skin injury or burn and scald.

11. nano silver gel as claimed in claim 10, wherein chafing is that tinea pedis, tinea cruris, comedo or acne cause a skin inflammation.

12. nano silver gel as claimed in claim 1, it comprises that in addition the promotion skin growth factor, anti-cicatrix produce composition or natural plant extracts.

13. nano silver gel as claimed in claim 12 promotes that wherein the skin growth factor is short epidermal growth element.

14. nano silver gel as claimed in claim 12, it is bismuth subgallate that wherein anti-cicatrix produces composition.

15. nano silver gel as claimed in claim 12, wherein natural plant extracts is an Aloe extract.

16. nano silver gel as claimed in claim 13, it is used for chafing, skin injury or burn and scald.

17. nano silver gel as claimed in claim 1, it is to transmit nano silver gel to comprise the telescopic gel device of a push-and-pull.

18. nano silver gel as claimed in claim 1, wherein the shape of this gel device transmission nano silver gel is mellow and full shape.

19. nano silver gel as claimed in claim 1, wherein said gel are cellulose derivative, acrylate polymer, acrylate derivative, alginic acid and Xanthan gum.

20. nano silver gel as claimed in claim 19, wherein said cellulose derivative are methylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose or hydroxyethyl-cellulose.

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