CN1765369A - Nano silver gel and its use - Google Patents
Nano silver gel and its use Download PDFInfo
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- CN1765369A CN1765369A CN 200410085928 CN200410085928A CN1765369A CN 1765369 A CN1765369 A CN 1765369A CN 200410085928 CN200410085928 CN 200410085928 CN 200410085928 A CN200410085928 A CN 200410085928A CN 1765369 A CN1765369 A CN 1765369A
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Abstract
The invention relates to a nano silver gel which comprises nano silver solution and aqueous gel, and can be used for treating female's lower genital tract inflammation, cervicitis or skin injury.
Description
Technical field
The present invention relates to a kind of nano silver gel, it comprises nanometer silver solution and hydrogel.Nano silver gel of the present invention can be used to treat urogenital tract infection under the women, cervicitis or skin injured area.
Background technology
Silver has generally acknowledged antibacterial effect, and it is by the oxygen therapy activity of blocking-up bacteria cell wall and suppress bacterium DNA replication to various microorganisms killing actions.Generally speaking, a kind of antibiotic roughly can kill 6 kinds of different antibionts, but silver but can kill 600 various bacteria.Add silver and be the not toxic material of tool, so the scope of application of silver is quite wide and with a long history.See through the mode of high-tech nanotechnology, make that silver particles is active to become big, antibacterial functions strengthens, and the quality of home environment and Personal hygiene is increased significantly.The silver ionized water solution that the nanoscale fine particle and the nanometer silver of silver discharged all has significant bactericidal effect.Nanometer silver all has 99.99% inhibition effect for escherichia coli, staphylococcus aureus, Salmonella and bacillus pyocyaneus etc. under the situation of many times of dilutions, the biological agent that its main cause itself has for silver.
Active silver ion can attract the sulfydryl on the pheron in the bacterial body, promptly combines, and the enzyme that contains sulfydryl is lost activity, and makes antibacterial death.It should be noted that: after antibacterial was killed by silver ion, silver ion can dissociate out from the antibacterial that dies again, continued viable bacteria is cooked multiple action again, was eliminated until all antibacterials.Hence one can see that, and the effect of nanometer silver is to belong to the long-acting type antibacterial, and effect is lasting.Nanometer silver utilizes the small-size effect and the skin effect of nano material, and the sterilizing power of silver is improved more.With regard to silver ion for sterilization mechanism, because silver ion just can destroy bacterial cell membrane under very low concentration; Or can attract the proteic sulfydryl of B in the bacterial body strongly, combination rapidly with it reduces the enzymatic activity of antibacterial protozoa, thereby produces antibacterial action; By the slow release silver ion, can bring into play persistent antibacterial effect simultaneously.
Vaginitis and cervicitis are reproductive tract inflammation under the higher women of sickness rate, and women and kinsfolk's thereof physical and mental health is had a significant impact.Though it is many to treat product in the market, all undesirable at aspects such as dosage form, using method, curative effects.
Colpitis is caused by antibacterial, mycete, chlamydia, mycoplasma, virus, protozoon etc.The vaginal infection source of disease can go upward to cavity of uterus, fallopian tube, ovary and pelvic cavity, thereby causes endometritis, salpingitis, oophoritis or the pelvic infection of acute and chronic, and chronic infection person even can cause intestinal obstructions and infertile except that the inflammation symptom.
Summary of the invention
The invention provides a kind of nano silver gel, preferably comprise the nanometer silver solution and the hydrogel of concentration 2 to 100ppm, wherein nanometer silver solution and hydrogel were with 1: 20 to 20: 1 weight ratio uniform mixing.
In the nano silver gel of the present invention, nanometer silver solution concentration is 2 to 100ppm, and preferred concentration is 10 to 50ppm, and most preferable concentrations is 20ppm.
In the nano silver gel of the present invention, the weight ratio of nanometer silver solution and hydrogel is 1: 20 to 20: 1, is mixing in 1: 10 to 10: 1 with weight ratio preferably, and most preferably weight ratio is 9: 1.
In the nano silver gel of the present invention, this gel is cellulose derivative (methylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose or hydroxyethyl-cellulose), acrylate polymer, acrylate derivative, alginic acid and Xanthan gum.
Nano silver gel of the present invention is to transmit nano silver gel with the telescopic gel device of a push-and-pull, and the shape that this glue device transmits nano silver gel is mellow and full shape.
Nano silver gel of the present invention is used for handling by various route of administration the application of various infection, it can be treated urogenital tract infection under the women (candidal vaginitis, antibacterial vaginitis, trichomonal vaginitis, senile vaginitis or vagina mixed infection) or cervicitis (chronic cervicitis or cervical erosion), be used for the skin injured area (chafing, skin injury or burn and scald, wherein chafing is that tinea pedis, tinea cruris, comedo or acne cause a skin inflammation).
Adding various pharmaceutical additives in the nano silver gel of the present invention makes and transmits dosage form and can handle and comprise and promote skin growth (adding short epidermal growth element), anti-cicatrix to produce (add anti-cicatrix and produce composition for example bismuth subgallate or natural plant extracts), treatment chafing, skin injury burn and scald (interpolation Aloe extract).
Description of drawings
Fig. 1 is the gel device of administration nano silver gel to site of disease.
Fig. 2 is that the administration nano silver gel is to the pushing cylinder of the gel device of site of disease and the situation of gel device cylindrical shell combination.
The explanation of diagram conventional letter:
10 gel devices
20 gel device cylindrical shells
30 pushing cylinders
40 resilient plugs
50 outlets
60 driving fits lid
70 nano silver gels
The specific embodiment
The invention provides nanometer silver and mix with a kind of hydrogel that is formed by crosslinked polymer, preparation technique and configuration proportion are as follows, use the nano-Ag particles of being buied by manufacturer with sterilization and antifungal ability, have been disclosed in US 2002051823.The compositions that has less than the nano-Ag particles of 100nm has been disclosed in WO 03080231.Add aquesterilisa and be deployed into the 20ppm nanometer silver solution.Buy Tegagel by the 3M of manufacturer again
TMHydrogel.20ppm nanometer silver solution and hydrogel are mixed with nano silver gel of the present invention with 9: 1 weight ratio.
Other replaceable Tegagel and the commercial gel that is contained among the present invention are listed in the table below:
| Manufacturer | ProductName | Manufacturer | ProductName |
| 3M | Tegagel | Hollister Inc. | Restore |
| Amerx Health Care | Amerigel Topical Ointment | Johnson & Johnson | NU-GEL |
| Bard Medical | Bard Absorption Dressing Biolex，Iamin | Kendall | CURAFIL |
| Carrington Laboratories | CarraSorb，Carrasyn DIAB GEL | Medline | SkinTegrity |
| Coloplast | Woun′Dres Purilon | Molnlycke Health Care | Hypergel Normlgel |
| ConvaTec | DuoDERM SAF-Gel | MPM Medical，Inc. | MPM |
| DermaRite | DermaSyn | ProCyte | Iamin |
| Health Point | CURASOL | Sage Laboratories | PanoPlex |
| Derma Sciences， Inc. | Dermagran |
The invention provides the route of administration of this nano silver gel in handling various infection.Before antibiotic was extensively used, people just had been found that silver has antimicrobial effect, and in order to sterilization, mainly were because the microorganism meeting produces drug resistance (resistence) to antibiotic, but silver can not.Nanometer silver used in the present invention can be applicable on the health product, includes but not limited to the cleaning agent of laundry detergents, women's acne, pimples, the soaking solution of toothpaste etc.Simultaneously also can be applicable to the hygiene medical treatment product, include but not limited to the patient of position, antibacterial or fungal infection position (comprising that gynecological infection is sick as vaginitis (vaginitis)), gastrointestinal tract bacterial infection and the infectious disease of do as one likes behavior of wound or burn and scald.In addition, nanometer silver solution also can be applicable on the industrial products, includes but not limited to the particularly preservation (particularly preventing the generation of mycete) of disinfectant, stationery and the engineering implant of preservation, the drinking water of fruit and vegetables of food.
The used nanometer silver compositions of the present invention has broad-spectrum sterilization and antifungal ability, and it can kill and stop the hypertrophy of antibacterial or mycete.These antibacterials or mycete comprise escherichia coli (Escherichiacoli), the staphylococcus aureus of anti-Methicilli71 (Staphylococcus aureus), chlamydia trachomatis (Chlamydia trachomatis), this figure Providian bacterium (Providenciastuartii), Vibrio vulnificus (Vibrio vulnificus), pneumobacillus (Pneumobacillus), nitrate-negative bacillus (bacillus), staphylococcus aureus (Staphylococcus aureus), Candida albicans (Candida albicans), Aerobacter cloacae (Bacillus cloacae), Bacillus allantoides (Bacillusallantoides), Morgan ' s bacillus (Salmonella naorgani), Pseudomonasmaltophila, Pseudomonas aeruginosa (Pseudomonas aeruginosa), gonococcus (Neisseriagonorrhoeae), bacillus subtilis (Bacillus subtilis), Bacillus foecalis alkaligenes (Bacillus foecalisalkaligenes), Streptococcus hemolyticus B (Streptococcus hemolyicus B), citric acid bacillus (Citrobacter) is with the third type paratyphoid fever Salmonella (Sahnonella paratyphi C).
Antibiotic and the antifungal ability of the nanometer silver compositions that the present invention is used compared to traditional antibiotic, has and can not cause the advantage that produces antibacterial or mycete with drug resistance.
Gel
The used gel of the present invention is from 3M Tegagel
TMThe wound hydrogel.This hydrogel is to be formed by crosslinked polymer, and its advantage is as clear as crystal hydrogel, can assist to moisten the processing of wound, and nonirritant.Because of Tegagel has 95% moisture content, can effectively reduce the pain of wound teleneuron, and be gel form, use easily.
Gel used in the present invention, its best occupation mode is for providing and keep the recovery environment of a humidity.Because the wetness around the affected part has improved, gel can be assisted cleaning and be removed slough or thalline.Gel also can be used for wound or burn and scald position.Another advantage of gel causes damage for removing Shi Buhui to the position, and its submissive sense of touch can improve patient's compliance.
Route of administration
Route of administration of the present invention is preferably external application, uses with solution, emulsion or ointment mode.The present invention can be applicable to skin, wound, eye, nose or mouth to prevent, to handle various infection.Compositions of the present invention can be used by known method, and one of them is to use with glove hands.Other special treatment of wounds mode also can be used at affected part together.The invention provides long-acting antimicrobial effect.
When compositions of the present invention was used to handle ocular infection, compositions of the present invention can solution or the mode of ointment, is applied to palpebra inferior with standard mode, or this compositions is made collyrium, is applied to eye with standard mode.
When compositions of the present invention was used to handle the mouth inflammation and comprises gingivitis, compositions of the present invention can solution or the form of ointment, uses in the mode of similar sponge or toothpaste.This compositions can also solution form inject intravital cavity and handle and infect.
Several advantages are arranged during the application mode administration beyond the compositions of the present invention.The first, the present invention does not contain any antibiotic that may make patient's discomfort.Secondly, the present invention can not make antibacterial or mycete produce drug resistance.In addition, nanometer silver is with respect to other metallic, can not dye on patient's skin or clothes.
Compositions of the present invention can be added other common pharmaceutical additive in addition, for example short epidermal growth element (EGF).Short epidermal growth element is a kind of important auxin, and it is the peptide chain that 50-60 amino acid molecular formed, and contains 6 cysteine molecules in the chain.The cystine linkage that the intermolecular formation of cysteine is stable makes the whole piece peptide chain become the active substance of three ring connection parts.Short epidermal growth element can promote the epidermal growth breeding, quickens the reparation of injured epidermis cell, and the gastric acid inhibitory secretion is pharmaceutically having very wide purposes.Short epidermal growth element can promote human body skin epithelial cell, corneal epithelial cell and mammal epithelial cell growth when tissue culture.Short epidermal growth element also often is applied to cosmetics, can promote the growth and breeding of skin histology, corneal epithelial tissue and gastric epithelial cell, quickens the reparation of corneal wound, strengthens the protein of epidermis cell, the synthetic and cellular metabolism of RNA.
Embodiment
The manufacture method of embodiment one nano silver gel
Buy nano-Ag particles by manufacturer, add aquesterilisa and be deployed into the 20ppm nanometer silver solution.Buy Tegagel by the 3M of manufacturer again
TMHydrogel.20ppm nanometer silver solution and hydrogel are mixed with nano silver gel 70 of the present invention with weight ratio at 9: 1.After nano silver gel 70 is fills up to gel device 10, gel device cylindrical shell 20 and pushing cylinder 30 contact jaws are with resilient plug 40 driving fits, the outlet 50 of gel device cylindrical shell 20 is covered 60 driving fits with driving fit, during use pushing cylinder 30 is pushed away resilient plug 40, allows gel from exporting 50 diseased regions of delivering to the patient.
Embodiment two nano silver gels treatment vaginitis and cervicitis
Obstetrics and gynecology hospital adopts nanometer silver type external use antibiotic gel for female external use to treat various vaginitis cervicitis from year January in August, 2003 to 2004.
1. materials and methods
The patient source:
2002.8～2004.1, meter is urogenital tract infection patient 92 examples down, vaginitis 47 examples wherein, mixed infection 3 examples.Patient age 18-51 year, average 31.2 years old.
2. test material
The nano silver gel that embodiment one is prepared.
3. diagnostic criteria
Vaginitis is made a definite diagnosis according to clinical manifestation and pathogen inspection; Cervical erosion is according to Cao Zeyi chief editor " Chinese obstetrics and gynecology ", according to rotten to the corn area be divided into slightly, moderate and severe, be divided into simple type, granular pattern and mastoid process type according to rotten to the corn surface.
4. Therapeutic Method
Behind the moon, the patient utilizes antibacterial gel to the gel device (see figure 1) is pushed the vagina deep under cleaning before sleeping every night, and 1 every night, logotype 6 days.The vaginitis patient treatment finishes check in back 3 days, and the cervicitis patient treatment finishes check in back 7 days.Inquiry patient subjective symptoms is improved situation, check vagina, trachelopanus situation and secretions is tested accordingly and checked.
5. efficacy assessment standard
(a) vaginitis (comprising monilial vaginitis and trichomonal vaginitis)
Recovery from illness: symptom and sign disappears, and leucorrhea reduces, leucorrhea lab testing feminine gender;
Produce effects: symptom and sign is clearly better, not complete obiteration as yet, leucorrhea lab testing feminine gender;
Take a turn for the better: symptom and sign alleviates, the leucorrhea lab testing positive (making invalid statistics);
Invalid: symptom and sign does not have improvement, the leucorrhea lab testing positive.
(b) bacterial vaginitis
Recovery from illness: symptom and sign disappears, vaginal secretions pH value＜4.5, and the amine test feminine gender is not seen clues cell (clue cells);
Produce effects: symptom and sign is clearly better but not complete obiteration as yet, and vaginal secretions pH value＜4.5 or amine test feminine gender are not seen clues cell;
Take a turn for the better: symptom and sign alleviates to some extent, vaginal secretions pH value＜4.5 or amine test feminine gender, the cell that picks up scent (making invalid statistics);
Invalid: symptom and sign, vaginal secretions lab testing all do not have obvious improvement.
The effective percentage of colpitis calculates: effective percentage=(recovery from illness+produce effects)/treat routine number * 100%.
(c) cervical erosion
Recovery from illness: symptom and sign disappears, and rotten to the corn face disappears, and cervix uteri is smooth;
Produce effects: symptom and sign is clearly better, not complete obiteration as yet, and rotten to the corn area dwindles 1/2, and severe transfers moderate to, moderate transfers to slightly;
Effectively: symptom and sign takes a turn for the better, not complete obiteration as yet, and rotten to the corn area dwindles＜and 1/2, or the mastoid process type is converted into granular pattern, granular pattern is converted into simple type;
Invalid: symptom and sign does not have improvement, rotten to the corn area no change.
Effective percentage=(recovery from illness+produce effects+effectively)/treat routine number * 100%.
(d) untoward reaction
Should pay close attention to untoward reaction in the therapeutic process, and the untoward reaction that itemized record occurred.
6. assay
(a) vaginitis
In the 47 routine vaginitiss, 38 example recoveries from illness, cure rate 80.9%; 7 routine produce effects, total effective rate 95.7% sees table 1 for details.
Table 1 nanometer silver type external use antibiotic gel for female external use is treated colpitic effect
| Type | The example number | Recovery from illness | Produce effects | Take a turn for the better | Invalid | Effective percentage (%) | |
| The example number | ％ | ||||||
| Monilial vaginitis bacterial vaginitis | 20 16 11 | 16 13 9 | 80.0 81.3 81.8 | 3 2 2 | 1 1 0 | 0 0 0 | 95.0 93.8 100.0 |
| Add up to | 47 | 38 | 80.9 | 7 | 2 | 0 | 95.7 |
(b) cervicitis
In the 42 example cervical erosion, slight 15 examples, effective percentage 93.3%; Moderate 17 examples, effective percentage 82.4%; Severe 10 examples, effective percentage 80%; Total effective rate 85.7% sees table 2 for details.
The effect of table 2 nanometer silver type external use antibiotic gel for female external use treatment cervicitis
| Type | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage (%) |
| Simple form is slight granular pattern simple form moderate granular pattern simple form severe granular pattern | 15 0 11 6 3 7 | 12 0 3 0 2 0 | 2 0 8 2 1 3 | 0 0 0 1 0 2 | 1 0 0 3 0 2 | 93.3 - 100.0 50.0 100.0 71.4 |
| Add up to | 42 | 17 | 16 | 3 | 6 | 85.7 |
(c) mixed infection
Observe in the case, have 3 examples to be mixed infection, wherein 1 example has bacterial vaginitis, trichomonal vaginitis, moderate cervical erosion simultaneously.Through the treatment of 6 days 1 courses of treatment, the bacterial vaginitis produce effects, the trichomonal vaginitis recovery from illness, cervical erosion transfers slightly (efficacy determination is a produce effects) to; 1 example is the patient of bacterial vaginitis, monilial vaginitis, severe cervical erosion.Treated 6 days, symptom is obviously improved, and bacterial vaginitis recovery from illness, candidiasis are turned out cloudy the rarely seen hyperemia of cervix uteri; 1 routine patient has infected trichomonal vaginitis and mycoplasma (Mycoplasma) simultaneously in addition; After 6 days, infusorian and mycoplasma are all turned out cloudy with the nano silver gel treatment.
(d) untoward reaction
2 routine patients tell the pruritus vulvae sense, the no abnormal discovery in back of stopping using.
7. discuss
(a) the effective ingredient nanometer silver of nanometer silver type external use antibiotic gel for female external use can extensively be imitated antibioticly, multiple pathogen such as antibacterial, fungus, infusorian is all had suppress or killing action.After general patient used 6 gels, pruritus vulvae or causalgia sense were clearly better, and secretions reduces, and abnormal flavour disappears.Treatment finishes the back check, and multiple vaginitis is all had definite curative effect.Cure rate 80.9%, total effective rate 95.7%.
(b) nanometer silver has the tissue repair of promotion and regenerated effect.Nano silver gel has obvious curative effects to cervicitis, particularly the simple type cervical erosion that infective agent is caused.To the cervical erosion that other factors cause, use the back symptom obviously to improve, trachelopanus alleviates, and secretions reduces, and helps carrying out second course of therapy or further does naturopathy.
(c) can cause behind a kind of pathogenic infection that the vagina ecological condition changes, cause the local defense function to descend, cause the secondary infection of other pathogen, this moment is single with the difficult good efficacy that obtains of a kind of Drug therapy.Under study for action, the patient of 3 routine vagina mixed infections, single with the outer externally used antimicrobial gel of nanometer silver women, through the treatment of 6 day course of treatment, patient's transference cure or obviously improvement, multiple pathogen is all turned out cloudy.
Urogenital tract infection under the embodiment three nano silver gels treatment women
Obstetrics and gynecology hospital in 2004 1 to March, adopt urogenital tract infection 60 examples under the nano silver gel treatment women of embodiment one, curative effect is summarized as follows:
1. case selection, diagnostic criteria and Therapeutic Method
(a) case is selected:
Be chosen in following urogenital tract infection patient 60 examples that outpatient service is gone to a doctor at random, cervical erosion 30 examples wherein, vaginitis (disease) 30 examples.Be first visit, and all not use any Drug therapy, age be 22 to 48 years old.
(b) cervical erosion diagnostic criteria:
Slight rotten to the corn: the cervical erosion face is less than 1/3 of whole cervix uteri area.
The moderate erosion: the cervical erosion face accounts for 1/2～2/3 of whole cervix uteri area.
The severe erosion: the cervical erosion face is greater than 2/3 of whole cervix uteri area.
Depth degree according to rotten to the corn area is divided into: simple type, granular pattern, mastoid process type.
(c) vaginitis (disease) diagnostic criteria:
Monilial vaginitis: pruritus vulvae, leucorrhoea grow in quantity are bean curd slag specimen or curdy, the leucorrhea microscopy candidiasis positive.
Trichomonal vaginitis: pruritus vulvae, leucorrhoea grow in quantity are yellowish foam sample, the leucorrhea microscopy trichomonal vaginitis positive.
Bacterial vaginitis: pruritus vulvae, leucorrhoea grow in quantity have the stench flavor of fish, the leucorrhea diluent amine test positive (being the bacterial vaginitis rapid detection card positive).
(d) Therapeutic Method:
After cleaning pudendum before the experimenter sleeps every night, with nano silver gel being pushed the vagina deep for gel device (asking for an interview Fig. 1), 1 time every night, 6 days is a course of treatment voluntarily.Treatment finishes back check in 3 to 7 days, comprises symptom, Signs and lab testing.
2. curative effect judging standard
(a) cervical erosion
Recovery from illness: symptom and sign disappears, and rotten to the corn face disappears, and cervix uteri is smooth.
Produce effects: symptom and sign obviously alleviates, and rotten to the corn reduction of area is little by 1/2, and severe transfers moderate to, and moderate transfers to slightly.
Effectively: symptom and sign partly alleviates, and rotten to the corn reduction of area is little＜1/2, or the mastoid process type transfers granular pattern to, and granular pattern transfers simple type to.
Invalid: symptom and sign does not have and alleviates rotten to the corn face no change.
Effective percentage=(recovery from illness+produce effects+effectively)/treat routine number * 100%.
(b) vaginitis (disease)
Recovery from illness: symptom and sign disappears, and leucorrhea reduces and microscopy pathogen (or amine test) feminine gender.
Produce effects: symptom and sign obviously alleviates, and leucorrhea reduces and microscopy pathogen (or amine test) feminine gender.
Take a turn for the better: symptom and sign partly alleviates, leucorrhea microscopy pathogen (or amine test) positive.
Invalid: symptom and sign does not have and alleviates leucorrhea microscopy pathogen (or amine test) positive.
Effective percentage=(recovery from illness+produce effects)/treat routine number * 100%.
3. result
(a) cervical erosion therapeutic outcome: in the 30 example patients of cervical ruin, slight 18 examples, effective percentage is 94%; Moderate 10 examples, effective percentage are 70%; Severe 2 examples, 1 example effectively.The total effective rate of treatment uterus item neck erosion is 83%, sees table 3 for details.
Table 3 nanometer Ag antibiotic gent for women is to the therapeutic effect of cervical erosion
| Type | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage (%) |
| Slight moderate severe | 18 10 2 | 7 0 0 | 9 3 0 | 1 4 1 | 1 3 1 | 94 70 50 |
| Add up to | 30 | 7 | 12 | 6 | 5 | 83 |
(b) vaginitis (disease) therapeutic outcome: among 30 routine vaginitis (disease) patients, monilial vaginitis 16 examples, effective percentage is 88%; Scorching 6 examples in infusorian property road, effective percentage is 100%; Bacterial vaginitis 8 examples, effective percentage are 88%.The total effective rate 90% of treatment vaginitis (disease) sees table 4 for details.
Table 4 nanometer silver type external use antibiotic gel for female external use is to the therapeutic effect of vaginitis (disease)
| Type | The example number | Recovery from illness | Produce effects | Take a turn for the better | Invalid | Effective percentage (%) |
| Monilial vaginitis trichomonal vaginitis bacterial vaginitis | 16 6 8 | 12 6 6 | 2 0 1 | 2 0 1 | 0 0 0 | 88 100 88 |
| Add up to | 30 | 24 | 3 | 3 | 0 | 90 |
Other result: the depth degree with cervical erosion is observed therapeutic effect, for the simple type curative effect best; In addition, have 5 routine patients to claim to treat during vagina the situation of discharging a little coffee-like secretions is arranged, but discomforts such as absence of vagina excitement.
The present invention describes in detail and illustrates, so that those who familiarize themselves with the technology can implement and be used, anyly substitutes, change all should carry out in not breaking away from spirit of the present invention and scope with modification.
Those who familiarize themselves with the technology is very fast can to find that just the present invention is easy to just can reach target, and obtains described result and advantage herein.Cell strain, embryo, animal and manufacture process thereof and method only are exemplary preferred embodiment representative, do not really want to limit scope of invention.Those of ordinary skill in the art will expect the present invention is made amendment and other purposes, and these modifications all should be included in the spirit of the present invention and only limit in the claim scope.
Those of ordinary skill in the art obviously are easy in not breaking away from spirit of the present invention and scope the present invention be changed and revises.
Described all patents of this description and publication are routine techniques relevant with invention in this area.The patent that this description is addressed can illustrate the skill level that the technical staff that is familiar with relevant field of the present invention has with publishing an article.
Invention accompanying drawing as herein described can be implemented under without any important document or restriction, and the disclosed person of nonspecific this paper.Employed noun and expression are only used for the purpose of illustration, but not be used for restriction, and be not to utilize these nouns and express get rid of any shown in and the equipollent of described or its Partial Feature, still may be in the patent application claim but think that various changes are revised.Therefore, though should understand utilized preferred embodiment and optionally feature specifically disclose the present invention, but those of ordinary skill in the art may be according to conception correct and the change disclosed in it, and these are revised and change should be in the defined scope of appended claims of the present invention.
Following claims are mentioned other embodiment.
Claims (20)
1. nano silver gel comprises the nanometer silver solution and the hydrogel of concentration 2 to 100ppm, and wherein nanometer silver solution and hydrogel were with 1: 20 to 20: 1 weight ratio uniform mixing.
2. nano silver gel as claimed in claim 1, wherein the concentration of nanometer silver solution is 10 to 50ppm.
3. nano silver gel as claimed in claim 2, wherein the concentration of nanometer silver solution is 20ppm.
4. nano silver gel as claimed in claim 1, wherein the weight ratio of nanometer silver solution and gel is 1: 10 to 10: 1.
5. nano silver gel as claimed in claim 4, wherein the weight ratio of nanometer silver solution and gel is 9: 1.
6. nano silver gel as claimed in claim 1, urogenital tract infection or cervicitis under its treatment women.
7. nano silver gel as claimed in claim 6, wherein urogenital tract infection is candidal vaginitis, antibacterial vaginitis, trichomonal vaginitis, senile vaginitis or vagina mixed infection under the women.
8. nano silver gel as claimed in claim 6, wherein cervicitis is chronic cervicitis or cervical erosion.
9. nano silver gel as claimed in claim 1, it is used for the skin injured area.
10. nano silver gel as claimed in claim 9, wherein the skin injured area is chafing, skin injury or burn and scald.
11. nano silver gel as claimed in claim 10, wherein chafing is that tinea pedis, tinea cruris, comedo or acne cause a skin inflammation.
12. nano silver gel as claimed in claim 1, it comprises that in addition the promotion skin growth factor, anti-cicatrix produce composition or natural plant extracts.
13. nano silver gel as claimed in claim 12 promotes that wherein the skin growth factor is short epidermal growth element.
14. nano silver gel as claimed in claim 12, it is bismuth subgallate that wherein anti-cicatrix produces composition.
15. nano silver gel as claimed in claim 12, wherein natural plant extracts is an Aloe extract.
16. nano silver gel as claimed in claim 13, it is used for chafing, skin injury or burn and scald.
17. nano silver gel as claimed in claim 1, it is to transmit nano silver gel to comprise the telescopic gel device of a push-and-pull.
18. nano silver gel as claimed in claim 1, wherein the shape of this gel device transmission nano silver gel is mellow and full shape.
19. nano silver gel as claimed in claim 1, wherein said gel are cellulose derivative, acrylate polymer, acrylate derivative, alginic acid and Xanthan gum.
20. nano silver gel as claimed in claim 19, wherein said cellulose derivative are methylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose or hydroxyethyl-cellulose.
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| CN100457084C (en) * | 2006-08-04 | 2009-02-04 | 武汉正午阳光医药生物科技有限公司 | Nanometer silver type external use antibiotic gel for female external use and its prepn. method |
| CN101856726A (en) * | 2010-06-17 | 2010-10-13 | 哈尔滨得意药业有限责任公司 | Method for preparing multifunctional nano silver solution |
| CN101278896B (en) * | 2008-05-23 | 2012-11-14 | 山东赛克赛斯药业科技有限公司 | Chitosan nano silver gel agent and uses thereof |
| CN103908473A (en) * | 2014-03-28 | 2014-07-09 | 湖南省轻工投资有限公司 | Nano-sliver anti-cancer composition for treating and preventing female carcinoma of uterine cervix as well as preparation method and application thereof |
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| CN106397793A (en) * | 2016-09-18 | 2017-02-15 | 中国医学科学院生物医学工程研究所 | L-alanine and L-glutamic acid-5-benzyl ester polypeptide copolymer hydrogel and application thereof |
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| CN106818940A (en) * | 2011-09-16 | 2017-06-13 | 罗伯特·怀特 | Antiseptic composition and its application |
| CN103908473B (en) * | 2014-03-28 | 2016-08-17 | 长沙迪谷纳米生物科技有限公司 | Treat and prevent the application of the nanometer silver anti-cancer composition of uterus neck cancer |
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| CN104922151A (en) * | 2015-07-22 | 2015-09-23 | 赵立 | Externally applied hydrogel preparation for women and preparing method thereof |
| CN106397793A (en) * | 2016-09-18 | 2017-02-15 | 中国医学科学院生物医学工程研究所 | L-alanine and L-glutamic acid-5-benzyl ester polypeptide copolymer hydrogel and application thereof |
| CN106474567A (en) * | 2016-11-16 | 2017-03-08 | 浙江省人民医院 | A kind of flexibility artificial skin and preparation method |
| CN106474567B (en) * | 2016-11-16 | 2019-08-02 | 浙江省人民医院 | A kind of flexibility artificial skin and preparation method |
| CN107007515A (en) * | 2017-06-13 | 2017-08-04 | 成都珂萝瑞诗化妆品有限公司 | A kind of women secret conditioning liquid and preparation method thereof |
| CN107468639A (en) * | 2017-08-29 | 2017-12-15 | 厦门康心元聚生物科技有限公司 | A kind of gynaecologic antibiotic gel and preparation method thereof |
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