CN110339121A - Bactericidal composition and the preparation method and application thereof - Google Patents
Bactericidal composition and the preparation method and application thereof Download PDFInfo
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- CN110339121A CN110339121A CN201910772773.4A CN201910772773A CN110339121A CN 110339121 A CN110339121 A CN 110339121A CN 201910772773 A CN201910772773 A CN 201910772773A CN 110339121 A CN110339121 A CN 110339121A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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Abstract
The present invention relates to chemical product technical field more particularly to bactericidal compositions and the preparation method and application thereof.Bactericidal composition used in the present invention is made of erythrina bark, dandelion, the coptis and wintergreen, non-stimulated to skin, and can effectively press down and kill harmful bacteria, is made into daily chemical product, is not required to additionally add preservative；And drug ingedient is free of by the women secret product containing the bactericidal composition, drug resistance will not be generated, and be not easy the substance being absorbed by the body without nano silver etc..Secret product provided by the invention can restore colony balance at secret, keep vaginal health collarium border；And the secret product contain Euglena gracilis polysaccharide, safflower extract, Leonurus extract and other functional ingredient can effective extensive vaginal walls elasticity, enhance the control force of muscle, achieve the effect that compact vagina, in addition can also play conditioning, nourishing and repair.
Description
Technical field
The present invention relates to chemical product technical field more particularly to bactericidal compositions and the preparation method and application thereof.
Background technique
With the quickening pace of modern life with work etc. pressure increase, more and more women suffer from gynecological disease,
Including vulva disease, guidance disease, uterine disease, diseases of fallopian tubes etc..Since people lack due understanding to gynecological disease,
In addition various bad life habits etc. cause some women's diseases to be burdened with, research shows that the main reason for causing gynecological disease is
Vagina is by bacterium infection, such as staphylococcus aureus, Escherichia coli, Candida albicans germ, under normal circumstances, vagina
In acidity, germ reproduction can be inhibited, the ability with self-cleaning antibacterial, but since cleaning mode is improper, it is used when cleaning vulva
The common cleaning supplies such as shower cream or perfumed soap, long-time service will cause that vaginal flora is unbalance, change the pH value of vagina, support it
Drag decline, to induce gynecological disease.
In recent years, since the disease of women privates is more and more common, for privates health care also increasingly by weight
Depending on therefore, privates care product is essential cleaning products in female life.It is directed to the production of gynaecological imflammation on the market at present
Product are many kinds of, including lotion class, spray class, gel-like.The sterilizing function of care product mainly adds chemistry everywhere at present
For fungicide come what is realized, common chemical difference military secret has bromination dodecyl dimethyl hexadecyldimethyl benzyl ammonium or 2,4,4 '-three chloro- 2 '-hydroxyls
Yl diphenyl ether etc., these chemical products are larger to the skin irritatin of women privates, and use for a long time can generate drug resistance, are easy
Women private portion physiological environment is destroyed, bacterium colony disorder is caused, generates lesion.Therefore, develop it is a kind of do not stimulate mildly, can effectively clearly
Clean privates, suppression kill harmful bacteria, the cleaning and nursing product of balance privates physiological environment has great importance.
Summary of the invention
In view of this, the technical problem to be solved in the present invention is that provide bactericidal composition and the preparation method and application thereof,
The composition can be sterilized effectively, and non-stimulated to skin.
Combination of compositions object provided by the invention, including erythrina bark, dandelion, the coptis and wintergreen.
In some embodiments, composition of the present invention is grouped as by the group of following mass parts:
In some specific embodiments, the composition is by 5 parts of 6 parts of erythrina bark, 8 parts of dandelion, 9 parts of the coptis, wintergreen groups
At.
In some specific embodiments, the composition is by 8 parts of erythrina bark, 10 parts of dandelion, 12 parts of the coptis, 10 parts of wintergreen
Composition.
In some specific embodiments, the composition is by 10 parts of erythrina bark, 13 parts of dandelion, 15 parts of the coptis, wintergreen 12
Part composition.
Composition provided by the invention is made of erythrina bark, dandelion, the coptis and wintergreen, and the composition is extracted to be had
Good antibacterial functions, particular for privates common bacteria, Candida albicans, staphylococcus aureus and Escherichia coli have good
Inhibiting effect.
The present invention also provides a kind of extracts, are made by above-mentioned composition.
The preparation method of the extract includes:
After erythrina bark, dandelion, the coptis, wintergreen are crushed, 110 DEG C~125 DEG C, with 80~100min of flooding, warp
Filtrate is collected by filtration, is concentrated into 1~1.1g (crude drug)/ml, medicinal extract is made, is refrigerated at 4 DEG C spare；
Supernatant is collected by centrifugation after 20~30 DEG C of 20~30min of extraction in the medicinal extract ethyl alcohol, is made described through dry
Extract.
Composition of the present invention, extract are preparing the application in antimicrobial product.
The present invention also provides a kind of antimicrobial products, which is characterized in that including above-mentioned composition or extract.
Wherein, in the secret nursing gel, the mass fraction of bactericidal composition of the present invention is 7%~12.5%；
Specially 7%, 10% or 12.5%.
Antimicrobial product of the present invention is chemical product, preferably personal care product.Specially secret nursing gel.
The present invention provides a kind of secret care agents comprising extract made from the method for the invention and privates maintenance
Ingredient.
The privates maintenance ingredient is handed over by houttuynia extract, Leonurus extract, Gentrin Knotweed P.E, safflower extract
Join carboxymethyl cellulose, Euglena gracilis polysaccharide, hydrolytic collagen and lactic acid are made.
Wherein, raw materials used or auxiliary material is available on the market in secret care agent.
Secret care agent of the present invention is made by following component；
The preparation method of secret care agent of the present invention includes:
70~75 DEG C are cooled to after boiling boiling, hydrolytic collagen, Euglena gracilis polysaccharide, cross-linked carboxymethyl cellulose is added, stirs
It mixes after dissolving 7000~8000r/min homogeneous 2~3 minutes；
After being cooled to 40~45 DEG C be added houttuynia extract, Leonurus extract, Gentrin Knotweed P.E, safflower extract and
Extract made from claim 4 the method, addition lactic acid stirs evenly after 400~500r/min stirs 20~30min, adjusts
The care agent is made for 3.8~4.5 in section pH.
Bactericidal composition used in the present invention is made of erythrina bark, dandelion, the coptis and wintergreen, stingless to skin
Swash, and can effectively press down and kill harmful bacteria, such as staphylococcus aureus, Candida albicans harmful bacteria.Daily chemical product is made into,
It is not required to additionally add preservative；And drug ingedient is free of by the women secret product containing the bactericidal composition, it will not generate
Drug resistance, and the substance being absorbed by the body is not easy without nano silver etc..Secret product provided by the invention can restore at secret
Colony balance keeps vaginal health collarium border.
Specific embodiment
The present invention provides bactericidal composition and the preparation method and application thereof, those skilled in the art can be used for reference in this paper
Hold, is suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are to those skilled in the art
For be it will be apparent that they are considered as being included in the present invention.Method and application of the invention, which has passed through, preferably to be implemented
Example is described, related personnel obviously can not depart from the content of present invention, in spirit and scope to methods herein and application
It is modified or appropriate changes and combinations, carrys out implementation and application the technology of the present invention.
The test material that the present invention uses is all common commercially available product, can all be bought in market.
Below with reference to embodiment, the present invention is further explained:
Embodiment 1
1 each group antibacterial combination composition formula of table
| Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | |
| Erythrina bark | 6 parts | 8 parts | 10 parts | 8 parts | 8 parts | -- |
| Dandelion | 8 parts | 10 parts | 13 parts | -- | 10 parts | -- |
| The coptis | 9 parts | 12 parts | 15 parts | 12 parts | -- | 12 parts |
| Wintergreen | 5 parts | 10 parts | 12 parts | -- | -- | 9 parts |
After erythrina bark, dandelion, the coptis, wintergreen are crushed, 120 DEG C, with flooding 90min, filtrate is collected by filtration,
It is concentrated into 1g (crude drug)/ml, medicinal extract is made, is refrigerated at 4 DEG C spare；
Supernatant is collected by centrifugation after 25 DEG C of extraction 30min in the medicinal extract ethyl alcohol, and the extract is made through drying.
One, Antimicrobial test
The different composition respectively acts on Escherichia coli, staphylococcus aureus and Candida albicans, presses
The germicidal efficiency in different time is tested according to professional standard QB/T 2738-2012, the results are shown in Table 2:
2 different time germicidal efficiency of table
As can be seen that fungistatic effect is different in different times from this table, wherein the fungistatic effect of group 3
It is best；In at the same time, for the group 4~6 for lacking certain components, the fungistatic effect for organizing 1-3 is more significant,
Illustrate that the composition of group 1~3 has synergistic effect well.Wherein, organize 3 fungistatic effect it is more excellent, especially in the short time
It is interior, it can more effectively kill harmful bacteria.
Embodiment 2
Antibacterial gel, formula such as table are prepared using the bactericidal composition in the group 3 and comparative example in embodiment 1 in group 4
2:
3 antibacterial gel formula of table
Gel the preparation method comprises the following steps:
It is cooled to 70~75 DEG C after boiling is boiled, hydrolytic collagen, Euglena gracilis polysaccharide, cellulose is added, stirring and dissolving is complete
Entirely, it is 8000r/min homogeneous 3 minutes in revolving speed, each plant extracts and bactericidal composition is added after cooling the temperature to 45 DEG C, then
Under conditions of revolving speed is 450r/min, uniform stirring 25min is added lactic acid and stirs evenly, and adjusts pH, and women shield is made in discharging
Manage gel.
Product evaluation
Test 1: antibacterial effect test:
Test method is imitated with reference to People's Republic of China's light industry standard QB/T2738-2012 daily chemical products antibacterial bacteriostatic
Fruit evaluation method, action time 20min.It the results are shown in Table 2:
Table 4: the antibacterial effect of embodiment and comparative example
The result shows that the antibacterial effect for organizing A~C is more significant, on the one hand, this illustrates in gel for group D~E
Component good mating reaction can be played to the antibacterial effect of composition.On the other hand, illustrate the composition tool of group A~C
There is good antibacterial effect, good inhibiting effect can be had to privates common bacteria by being used to prepare secret nursing gel.
Experiment 2: beneficial bacterium growth effect test
Select influence of the secret nursing gel of Lactobacillus acidophilus test group A-F preparation to probiotics.Vaccination ways use
Test tube is inoculated with Lactobacillus acidophilus.
5 case study on implementation of table and comparison case are to beneficial bacterium growth effect effect
State the experimental results showed that, the embodiment of the present invention and comparative example to the influence of women private parts beneficial bacterium not
Obviously, show that the present composition is smaller to the growth effect of beneficial bacterium while killing private parts pathogenic bacteria, make for a long time
It is safe with comparing, and have good effect for the prevention of vaginitis.
Experiment 3: vulva and Vaginal irritation effects experiment
Take regular grade Female New Zealand rabbit 12,2~2.5kg of weight, be randomly divided into 4 groups, experimental group be present invention group 1~
The privates nursing gel of 3 preparations, control group are sterilized physiological saline, and each 3, whether there is or not divide for pretest inspection animal introitus
Secretion, hyperemia, oedema and other situations.Animal is faced upward fixation, introitus is exposed, it is light after conduit is soaked with physiological saline
It is inserted into softly vagina (4~5cm), and is slowly injected into 2mL tested material with syringe, withdrawal conduit completes contamination.After 24 hours,
Animal is put to death using air embolism method, completely cuts longitudinally slit after vagina, whether visually observe has phenomena such as congested, oedema.
6 vulva of table and Vaginal irritation effects experimental result
The result shows that: the animal vagina mucosa of experimental group A~B has no hyperemia, oedema, erosion, vaginal mucosa irritation index <
1, thus illustrate, the privates nursing gel product of experimental group A and B are non-stimulated to vagina mucosa, and when antibacterial group in experimental group C
When the concentration for closing object is 12.5%, there is slight irritation.
As can be seen that privates care product provided by the invention is golden yellow to private portion's common pathogen from the above experimental result
Color staphylococcus, Escherichia coli and Candida albicans have significant antibacterial activity, can safeguard private portion's colony balance.And pass through yin
Mucous membrane stimulation test is it can be concluded that bactericidal composition is non-stimulated to mucous membrane and fungistatic effect can achieve 90% or more.
The above is only the preferred embodiment of the present invention, it is noted that those skilled in the art are come
It says, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as
Protection scope of the present invention.
Claims (10)
1. composition, including erythrina bark, dandelion, the coptis and wintergreen.
2. composition according to claim 1, which is characterized in that be grouped as by the group of following mass parts:
3. a kind of extract, which is characterized in that be made by composition of any of claims 1 or 2.
4. the preparation method of extract described in claim 3 characterized by comprising
After erythrina bark, dandelion, the coptis, wintergreen are crushed, 110 DEG C~125 DEG C, with 80~100min of flooding, through filtering
Filtrate is collected, 1~1.1g (crude drug)/ml is concentrated into, medicinal extract is made；
Supernatant is collected by centrifugation after 20~30 DEG C of 20~30min of extraction in the medicinal extract ethyl alcohol, and the extraction is made through drying
Object.
5. made from extract described in composition as claimed in claim 1 or 2 or claim 3 or claim 4 the method
Extract is preparing the application in antimicrobial product.
6. a kind of antimicrobial product, which is characterized in that including being extracted described in composition as claimed in claim 1 or 2 or claim 3
Extract made from object or claim 4 the method.
7. a kind of secret care agent, which is characterized in that including extract made from claim 4 the method and privates maintenance at
Point.
8. secret care agent according to claim 7, which is characterized in that for the privates maintenance ingredient by cordate houttuynia, benefit is female
Grass, polygonum cuspidate, safflower, cross-linked carboxymethyl cellulose, Euglena gracilis polysaccharide, hydrolytic collagen and lactic acid are made.
9. secret care agent according to claim 7 or 8, which is characterized in that it is made by following component；
10. the preparation method of any one of the claim 7~9 secret care agent characterized by comprising
70~75 DEG C are cooled to after boiling boiling, hydrolytic collagen, Euglena gracilis polysaccharide, cross-linked carboxymethyl cellulose is added, is stirred molten
7000~8000r/min homogeneous 2~3 minutes after solution；
Houttuynia extract, Leonurus extract, Gentrin Knotweed P.E, safflower extract and right are added after being cooled to 40~45 DEG C
It is required that extract made from 4 the methods, addition lactic acid is stirred evenly after 400~500r/min stirs 20~30min, adjusts pH
The care agent is made for 3.8~4.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910772773.4A CN110339121A (en) | 2019-08-21 | 2019-08-21 | Bactericidal composition and the preparation method and application thereof |
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| CN201910772773.4A CN110339121A (en) | 2019-08-21 | 2019-08-21 | Bactericidal composition and the preparation method and application thereof |
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| CN110339121A true CN110339121A (en) | 2019-10-18 |
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| CN201910772773.4A Pending CN110339121A (en) | 2019-08-21 | 2019-08-21 | Bactericidal composition and the preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111514181A (en) * | 2020-04-01 | 2020-08-11 | 广州睿森生物科技有限公司 | Antibacterial composition, antibacterial composite nano-particles, preparation method of antibacterial composite nano-particles and targeted slow-release nano-private gel |
| CN113975204A (en) * | 2021-10-12 | 2022-01-28 | 康密(上海)健康管理有限公司 | Anti-aging and toxin-expelling essence for female private and activation method |
-
2019
- 2019-08-21 CN CN201910772773.4A patent/CN110339121A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111514181A (en) * | 2020-04-01 | 2020-08-11 | 广州睿森生物科技有限公司 | Antibacterial composition, antibacterial composite nano-particles, preparation method of antibacterial composite nano-particles and targeted slow-release nano-private gel |
| CN111514181B (en) * | 2020-04-01 | 2022-10-04 | 广州睿森生物科技有限公司 | Antibacterial composition, antibacterial composite nano-particles, preparation method of antibacterial composite nano-particles and targeted slow-release nano-private gel |
| CN113975204A (en) * | 2021-10-12 | 2022-01-28 | 康密(上海)健康管理有限公司 | Anti-aging and toxin-expelling essence for female private and activation method |
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