CN109432204A - A kind of silver ion is spraying and preparation method thereof - Google Patents
A kind of silver ion is spraying and preparation method thereof Download PDFInfo
- Publication number
- CN109432204A CN109432204A CN201811569206.0A CN201811569206A CN109432204A CN 109432204 A CN109432204 A CN 109432204A CN 201811569206 A CN201811569206 A CN 201811569206A CN 109432204 A CN109432204 A CN 109432204A
- Authority
- CN
- China
- Prior art keywords
- spraying
- silver ion
- extract
- parts
- bactericidal composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
It is spraying that the invention discloses a kind of silver ions comprising following weight percentage components: collargol 0.2%~1.5%, bactericidal composition 1.6%~19% and collagen 0.5%~2%；The bactericidal composition includes the component of following parts by weight: 0.5~5 part of shrubby sophora extract, 0.5~5 part of common cnidium fruit P.E, 0.2~3 part of safflower extract, 0.2~3 part of Herba Agrimoniae extract and 0.2~3 part of Cortex Dictamni extract.The silver ion of inventive formulation is spraying easy to use, have both excellent anti-microbial property and performance of keeping humidity, excellent inhibiting effect is shown to the bacteriums such as staphylococcus aureus, Candida albicans and trichmonad, to effectively prevent and alleviate the gynecological diseases such as pudendal pruritus, inflammation, privates skin is made to keep wet after, is conducive to private parts and maintains ph balancing, improve the defense function of privates, and impaired skin healing can be promoted, safety is mild non-stimulated, and nursing role is good.
Description
Technical field
The present invention relates to a kind of cosmetics more particularly to a kind of silver ion for the nursing of women privates is sprayed and its preparation
Method.
Background technique
Privates is one of the significant points of women maintenance, nurses improper meeting and is easy to induce vaginitis, gynecopathy such as pelvic inflammatory disease
Disease.With the enhancing of people's health consciousness, more and more women start to focus on the maintenance and nursing of privates.Currently, most of
Women is to carry out privates nursing using commercially available privates cleaning solution.Commercially available privates cleaning solution uses chemical classes antibacterial mostly
Agent, long-time service can destroy private parts ph balancing, enable beneficial bacterium that can not grow, thus under causing the natural defense function of privates
Drop, pathogen are easy to invade.Privates once infect, pathogen will mad flourish, lead to the generation of gynecological disease, even
Induce venereal disease and infertility.
Vaginitis (vaginitis) i.e. colpitis is common gynecological disease, and there are about 70% or more women with yin
Road is scorching, seriously affects the normal family life of patient.The common vaginitis of gynaecology has monilial vaginitis and trichomonas vagina
Inflammation etc.；Monilial vaginitis mostly be by Candida albicans cause colpitis, patient clinical be mainly shown as vulva cusalgia,
Itch, leucorrhea increasing are in bean dregs sample, with urgent urination, urodynia, frequent micturition or feel restless when serious；Trichomonas vaginitis is by hair
Colpitis caused by trichomonad, patient clinical are mainly shown as vaginal mucosa inflammation, are in cerise, above cover patch shape pseudomembrane, often
With foam sample secretion, conscious different degrees of itch, minority has burning heat sensation etc..Clinic is usually taken drug and is treated, wherein
Conventional western medicine is widely used in clinic, although related symptoms can be effectively relieved, be easy recurrent exerbation, cause prognosis compared with
Difference.
Summary of the invention
It is an object of the invention to solve above-mentioned shortcoming and defect existing in the prior art, provide a kind of private for women
The silver ion of place's nursing is spraying and preparation method thereof.The silver ion is spraying to the common pathogen and trichmonad for causing vaginitis
With significant inhibiting effect, pudendal pruritus, inflammation etc. are can effectively prevent and alleviated, there is good nursing role, and will not
Destroy the ph balancing of female private part.
To realize its purpose, the technical scheme adopted by the invention is as follows:
A kind of silver ion is spraying comprising following weight percentage components: collargol 0.2%~1.5%, antibacterial combination
Object 1.6%~19% and collagen 0.5%~2%；The bactericidal composition includes the component of following parts by weight: kuh-seng extracts
0.5~5 part of object, 0.5~5 part of common cnidium fruit P.E, 0.2~3 part of safflower extract, 0.2~3 part of Herba Agrimoniae extract and shaggy-fruited dittany
0.2~3 part of bark extract.
Silver is one of the microelement in tissue, and micro silver is harmless to human body.The chemical structure of silver determines
Silver-colored catalytic capability with higher, the reduction potential of high oxidation state silver are high, it is sufficient to its surrounding space be made to generate elemental oxygen.Atom
There is oxygen strong oxidizing property can sterilize, and Ag can consumingly attract the sulfydryl (- SH) in bacterial body on protease, tie with it rapidly
It is combined, makes protease loss of activity, lead to bacterial death, after bacterium is killed by Ag, Ag in bacterium corpse again by dissociating
Out, then with other bacterium colonies it contacts.Silver ion is added middle by spraying, has the advantages that the alternative chemical classes of 1. silver ions are anti-
Rotten additive greatly improves spraying safety in utilization to make spraying realization preservative free addition；2. making other in spraying
Effect component is more fresh and alive, purer, can more give full play to its effect；3. the healing of skin wound can be promoted, increase impaired thin
Born of the same parents' repair function；4. effectively improving spraying moist infiltration effect, the absorption conducive to skin to nutriment；5. making natural by spraying
Have the Initiative Defense function to bacterium and directly inhibit infringement of the bacterium to skin in turn, much since bacterium itself is to flesh
Malaise symptoms caused by skin and body mucosal tissue damage can also be readily solved, such as skin allergy, inflammation, indecency body odour, face
Sore, dandruff etc..The trade name " silver-colored solution-B " for the collargol that the present invention uses, being purchased from Guangzhou Jin Mairong biotechnology has
Limit company.
Collagen has efficient moisture-retention ingredient, being capable of skin-active and inducing tissue regeneration.Collagen or human body connective
Main bonding substance in tissue, molecular weight is big, moisture-retaining capacity more preferably compared with polyalcohols, mainly to support cell, especially
Suitable for after skin exfoliating, skin be in physical therapy made by the most thin stage protect, while collagen have good infiltration
Property.
The present invention has found that collargol, the bactericidal composition and collagen are matched with above-mentioned by a large amount of creative researches
When than compounding, the silver ion can have both excellent anti-microbial property and performance of keeping humidity simultaneously by spraying, to staphylococcus aureus etc.
Bacterium, Candida albicans and trichmonad show excellent inhibiting effect, to effectively prevent and alleviate pudendal pruritus, inflammation etc.
Gynecological disease makes privates skin keep wet after, is conducive to private parts and maintains ph balancing, and can promote impaired skin healing,
Safety is mild non-stimulated, and nursing role is good.
In the bactericidal composition, kuh-seng (SOPHORA FLAVESCENS) extract alkaloid containing there are many, to a variety of
Biology and fungi have different inhibiting effect, have the effect of antibacterial and anti-inflammatory.Shrubby sophora extract can also effectively facilitate collagen egg
White generation has anti-aging function, also has effects that good moisturizing, water holding, has water supplement function.Frutus cnidii
(CNIDIUM MONNIERI) extract has antimycotic effect, has good function for treatment acute exudative skin disease
Effect, while can nourishes rough skin.Safflower (CARTHAMUS TINCTORIUS) extract is that the natural pigment that extracts from safflower is red
Anthoxanthin and safflower red pigment etc., safety edible are used.Safflower extract has the effects that promoting blood circulation, anti-inflammatory and anti-oxidant, docking
Touching property dermatitis, seborrheic dermatitis, pruritus and neurodermatitis have therapeutic effect.Herba Agrimoniae extract, which has, promotes blood solidifying
Gu, the effect of antibacterial, anti parasitic and anti-inflammatory.Cortex Dictamni extract has heat-clearing and damp-drying drug, the effect of wind-dispelling removing toxic substances, to a variety of causes
Germ has different degrees of inhibitory effect.The present invention has found that shrubby sophora extract, frutus cnidii are extracted by a large amount of creative researches
When object, safflower extract, Herba Agrimoniae extract and Cortex Dictamni extract are compounded with said ratio, in antibiosis there is collaboration to increase
Effect effect, to make the bactericidal composition that there is staphylococcus aureus, Escherichia coli, Candida albicans and trichmonad etc.
Excellent inhibition effect.
Preferably, the silver ion includes following weight percentage components by spraying: collargol 0.5%~1.5%, antibacterial
Composition 10%~15% and collagen 0.5%~1.5%.The present invention is found through experiments that, is prepared with the formula
The spraying antibacterial and moistening effect of silver ion is more preferably.
Preferably, the silver ion includes following weight percentage components by spraying: collargol 1%, bactericidal composition
12% and collagen 1%.The present invention is found through experiments that, the spraying antibacterial and moisturizing of the silver ion being prepared with the formula
Effect is best.
Preferably, the bactericidal composition includes the component of following parts by weight: 2~4 parts of shrubby sophora extract, frutus cnidii extract
2~4 parts of object, 1.5~2.5 parts of safflower extract, 1.5~2.5 parts of Herba Agrimoniae extract and 1.5~2.5 parts of Cortex Dictamni extract.
At this point, the bactericidal composition to inhibition effects of the pathogenic bacteria such as staphylococcus aureus, Escherichia coli and Candida albicans more
It is good.
Preferably, the bactericidal composition includes the component of following parts by weight: 3 parts of shrubby sophora extract, common cnidium fruit P.E 3
Part, 2 parts of safflower extract, 2 parts of Herba Agrimoniae extract and 2 parts of Cortex Dictamni extract.At this point, the bactericidal composition is to golden yellow
Inhibition effect of the pathogenic bacteria such as staphylococcus, Escherichia coli and Candida albicans is best.
Preferably, the silver ion further includes following weight percentage components by spraying: thickening suspending agent 0.2%~
0.6% and moisturizer 1%~10%.Preferably, the thickening suspending agent is the mixture of Arabic gum natural gum and xanthan gum,
INCI it is entitled " Arabic gum natural gum (and) xanthan gum ", trade name " SOLAGUMTMAX ", be purchased from Guangzhou hundred win well it is limited
Company.Preferably, the moisturizer is 1,3-BDO.
Preferably, the silver ion is spraying by forming following weight percentage components: collargol 0.2%~1.5% resists
Bacteria composition 1.6%~19%, collagen 0.5%~2%, thickening suspending agent 0.2%~0.6%, moisturizer 1%~10%
And deionized water surplus.
Preferably, the silver ion is spraying by forming following weight percentage components: collargol 0.5%~1.5% resists
Bacteria composition 10%~15%, collagen 0.5%~1.5%, thickening suspending agent 0.2%~0.6%, moisturizer 3%~5%
And deionized water surplus.
Preferably, the silver ion is spraying by forming following weight percentage components: collargol 1%, bactericidal composition
12%, collagen 1%, thickening suspending agent 0.4%, moisturizer 4% and deionized water surplus.
Preferably, the spraying preparation method of the silver ion includes the following steps: thickening suspending agent, moisturizer and goes
Ionized water is mixed and heated to 70~80 DEG C, is cooled down after mixing evenly, and when temperature drops to 40~45 DEG C, collargol, antibacterial is added
Composition and collagen, stir evenly.
The present invention also provides the spraying application method of the silver ion, specifically: after shower, the silver ion is sprayed
It is sprayed on privates in right amount, 3~5min is gently massaged and is then cleaned up with clear water with promoting skin to absorb.
Compared with prior art, it is spraying easy to use that the beneficial effects of the present invention are the silver ions of: inventive formulation, simultaneous
Have excellent anti-microbial property and performance of keeping humidity, the bacteriums such as staphylococcus aureus, Candida albicans and trichmonad is shown excellent
Different inhibiting effect makes privates skin keep wet to effectively prevent and alleviate the gynecological diseases such as pudendal pruritus, inflammation after
Profit is conducive to private parts and maintains ph balancing, improves the defense function of privates, and can promote impaired skin healing, the mild nothing of safety
Stimulation, nursing role are good.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, the present invention passes through the following example furtherly
It is bright.It should be understood that the embodiment of the present invention is merely to illustrate technical effect of the invention, protection model and is not intended to limit the present invention
It encloses.In embodiment, method therefor is conventional method unless otherwise instructed.
Embodiment
Examples 1 to 9 is the spraying embodiment of silver ion of the present invention, and formula is as shown in table 1.
The silver ion spray formula (weight percent) of 1 Examples 1 to 9 of table
The silver ion of above-described embodiment is spraying the preparation method comprises the following steps: SOLAGUMTMAX, 1,3 butylene glycol and deionized water
It is mixed and heated to 75 DEG C, cools down after mixing evenly, when temperature drops to 45 DEG C, sequentially add silver-colored solution-B, shrubby sophora extract, snake
Machine tool extract, safflower extract, Herba Agrimoniae extract, Cortex Dictamni extract and collagen, stir evenly.
Comparative example 1~5 provides that a kind of silver ion is spraying, and formula is as shown in table 2.
The silver ion spray formula (weight percent) of 2 comparative example 1~5 of table
The spraying preparation method of the silver ion of the above-mentioned comparative example preparation method spraying referring to the silver ion of embodiment.
One, stability test
Stability test is carried out by spraying to the silver ion of Examples 1 to 9.Method: silver obtained by Examples 1 to 9 from
Son is spraying to be respectively placed under different temperature (48 DEG C, room temperature, 5 DEG C and -18 DEG C), has been seen whether after one month abnormal
(including whether to change colour, if be precipitated, if layering), the results are shown in Table 3.
3 stability test result of table
| Test condition | 48℃ | Room temperature | 5℃ | -18℃ |
| Embodiment 1 | Without abnormal | Without abnormal | Without abnormal | Without abnormal |
| Embodiment 2 | Without abnormal | Without abnormal | Without abnormal | Without abnormal |
| Embodiment 3 | Without abnormal | Without abnormal | Without abnormal | Without abnormal |
| Embodiment 4 | Without abnormal | Without abnormal | Without abnormal | Without abnormal |
| Embodiment 5 | Without abnormal | Without abnormal | Without abnormal | Without abnormal |
| Embodiment 6 | Without abnormal | Without abnormal | Without abnormal | Without abnormal |
| Embodiment 7 | Without abnormal | Without abnormal | Without abnormal | Without abnormal |
| Embodiment 8 | Without abnormal | Without abnormal | Without abnormal | Without abnormal |
| Embodiment 9 | Without abnormal | Without abnormal | Without abnormal | Without abnormal |
Table 3 the result shows that: the silver ion of Examples 1 to 9 has preferable stability by spraying.
Two, in the spraying spray bottle of threading respectively of the silver ion of Examples 1 to 9, the pump head of spray bottle is pressed, liquid is observed
Whether uniformly sprayed, the results are shown in Table 4.
Table 4
Three, product biocidal property is tested
Biocidal property test is carried out by spraying as test sample using the silver ion of Examples 1 to 9 and comparative example 1~5 respectively:
1, test index bacterium bag includes Escherichia coli, Candida albicans and staphylococcus aureus；
2, the preparation of bacteria suspension: strain is inoculated in medium slant, is washed away on inclined-plane after culture with phosphate buffer
Lawn counts after mixing, is prepared into the bacteria suspension for meeting bacteria containing amount requirement；
3, bacteriostatic test: be added in sterile test tube test sample (positive controls use phosphate buffer) 8mL with
Bacteria suspension 0.1mL is mixed, effect to 20min.It takes the sample liquid 0.1mL mixed well to be inoculated with sterilized petri dishes, pours into thawing immediately simultaneously
It is cooled in 45 DEG C of agar medium and mixes.After to be solidified, after being cultivated 49 hours under the conditions of each inoculation plate is placed in 37 DEG C
Observation is as a result, calculate bacteriostasis rate；
4, the calculation formula of bacteriostasis rate: bacteriostasis rate (%)=(positive controls be averaged bacterium number-experimental group be averaged bacterium number)/sun
Property control group is averaged bacterium number × 100%.
Test result is as shown in table 5.
The antibacterial test result of table 5
Table 5 the result shows that, the silver ion of the embodiment of the present invention is spraying to Escherichia coli, staphylococcus aureus and white
Candida albicans all shows good inhibiting effect, can be effective when illustrating that silver ion of the invention is used for the nursing of women privates by spraying
The generation of the gynecological diseases such as pudendal pruritus and inflammation is prevented and alleviated, and private parts can be enhanced to the resilience of pathogenic bacteria.
Comparing embodiment 1~3 it is found that the component proportion of bactericidal composition can impact spraying bacteriostasis property, and
Shrubby sophora extract: common cnidium fruit P.E: safflower extract: Herba Agrimoniae extract: when Cortex Dictamni extract=3:3:2:2:2, resist
The bacteriostasis efficacy of bacteria composition is best.
Comparing embodiment 1, embodiment 4, embodiment 5, embodiment 8 and embodiment 9 are it is found that sprayability made from embodiment 1
Can be optimal, therefore, the present invention is using embodiment 1 as optimization formula.
Comparing embodiment 1 and comparative example 1~5 are it is found that the component missing of bactericidal composition can cause shadow to spraying performance
It rings, especially influences its inhibiting effect to staphylococcus aureus and Candida albicans.Thus it also indicates that, shrubby sophora extract, snake
Machine tool extract, safflower extract, Herba Agrimoniae extract and Cortex Dictamni extract compounding have synergistic make in antibiosis
With showing excellent inhibition effect to staphylococcus aureus, Escherichia coli and Candida albicans.
Four, use case
1. method: randomly selecting 50 female patients, find trichmonad in all equal Via vagina secretion of patient and make a definite diagnosis simultaneously
With strong pruritis, every patient all using the spraying primary of embodiment 1, records a patient's daily every other week
Whether pruritis has improvement, and the vaginal fluid of patient is taken to take away microscopy.
2. curative effect judges:
Cure: pruritis completely disappears, and leukorrhea is reduced, and vaginal fluid smear for microscopic examination is feminine gender.
Improve: pruritis is substantially reduced, and leukorrhea is reduced, and vaginal fluid smear for microscopic examination is feminine gender.
Invalid: though pruritis has mitigation, vaginal fluid smear for microscopic examination is the positive.
Curative effect is recorded and counts, the results are shown in Table 6.
6 curative effect of table
| First week | Second week | Third week | 4th week | |
| It cures | 6 | 17 | 26 | 35 |
| It improves | 34 | 29 | 23 | 15 |
| In vain | 10 | 4 | 1 | 0 |
As seen from the results in Table 6, the silver ion of embodiment 1 is spraying has a better effect women vaginitis tool, uses second
Week, nearly all patient are improved, and use 4th week, and all patients are improved.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of silver ion is spraying, which is characterized in that including following weight percentage components: collargol 0.2%~1.5%,
Bactericidal composition 1.6%~19% and collagen 0.5%~2%；The bactericidal composition includes the component of following parts by weight:
0.5~5 part of shrubby sophora extract, 0.5~5 part of common cnidium fruit P.E, 0.2~3 part of safflower extract, Herba Agrimoniae extract 0.2~3
Part and 0.2~3 part of Cortex Dictamni extract.
2. silver ion as described in claim 1 is spraying, which is characterized in that the silver ion includes following weight percent by spraying
Component: collargol 0.5%~1.5%, bactericidal composition 10%~15% and collagen 0.5%~1.5%.
3. silver ion as claimed in claim 2 is spraying, which is characterized in that the silver ion includes following weight percent by spraying
Component: collargol 1%, bactericidal composition 12% and collagen 1%.
4. silver ion as described in claim 1 is spraying, which is characterized in that the bactericidal composition includes the group of following parts by weight
Point: 2~4 parts of shrubby sophora extract, 2~4 parts of common cnidium fruit P.E, 1.5~2.5 parts of safflower extract, Herba Agrimoniae extract 1.5~
2.5 parts and 1.5~2.5 parts of Cortex Dictamni extract.
5. silver ion as claimed in claim 4 is spraying, which is characterized in that the bactericidal composition includes the group of following parts by weight
Point: 3 parts of shrubby sophora extract, 3 parts of common cnidium fruit P.E, 2 parts of safflower extract, 2 parts of Herba Agrimoniae extract and Cortex Dictamni extract 2
Part.
6. silver ion as described in claim 1 is spraying, which is characterized in that the silver ion further includes following weight percent by spraying
The component of ratio: thickening suspending agent 0.2%~0.6% and moisturizer 1%~10%；Preferably, the thickening suspending agent is for I
The mixture of primary gum glue and xanthan gum；Preferably, the moisturizer is 1,3-BDO.
7. silver ion as described in any one of claims 1 to 6 is spraying, which is characterized in that the silver ion is spraying by weighing as follows
The group of amount percentage is grouped as: collargol 0.2%~1.5%, bactericidal composition 1.6%~19%, collagen 0.5%~
2%, suspending agent 0.2%~0.6%, moisturizer 1%~10% and deionized water surplus are thickened.
8. silver ion as claimed in claim 7 is spraying, which is characterized in that the silver ion is spraying by following weight percent
Group is grouped as: collargol 0.5%~1.5%, bactericidal composition 10%~15%, collagen 0.5%~1.5%, thickening are outstanding
Floating agent 0.2%~0.6%, moisturizer 3%~5% and deionized water surplus.
9. silver ion as claimed in claim 8 is spraying, which is characterized in that the silver ion is spraying by following weight percent
Group is grouped as: collargol 1%, bactericidal composition 12%, collagen 1%, thickening suspending agent 0.4%, moisturizer 4% and go from
Sub- water surplus.
10. such as the spraying preparation method of the described in any item silver ions of claim 7~9, which is characterized in that including walking as follows
It is rapid: thickening suspending agent, moisturizer and deionized water being mixed and heated to 70~80 DEG C, cooled down after mixing evenly, temperature drops to
At 40~45 DEG C, collargol, bactericidal composition and collagen is added, stirs evenly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811569206.0A CN109432204B (en) | 2018-12-20 | 2018-12-20 | Silver ion spray and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811569206.0A CN109432204B (en) | 2018-12-20 | 2018-12-20 | Silver ion spray and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109432204A true CN109432204A (en) | 2019-03-08 |
| CN109432204B CN109432204B (en) | 2021-07-27 |
Family
ID=65560441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811569206.0A Active CN109432204B (en) | 2018-12-20 | 2018-12-20 | Silver ion spray and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109432204B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116898901A (en) * | 2023-08-14 | 2023-10-20 | 陕西科技大学 | External genitalia nursing spray and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618009A (en) * | 2008-07-03 | 2010-01-06 | 中山大学 | Nano silver targeted temperature-sensitive spray gel for vagina and preparation method thereof |
| CN107661494A (en) * | 2017-11-20 | 2018-02-06 | 方晓东 | It is a kind of to be used for gynaecological imflammation, the Chinese medicine composition gel of koro and its production technology |
-
2018
- 2018-12-20 CN CN201811569206.0A patent/CN109432204B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618009A (en) * | 2008-07-03 | 2010-01-06 | 中山大学 | Nano silver targeted temperature-sensitive spray gel for vagina and preparation method thereof |
| CN107661494A (en) * | 2017-11-20 | 2018-02-06 | 方晓东 | It is a kind of to be used for gynaecological imflammation, the Chinese medicine composition gel of koro and its production technology |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116898901A (en) * | 2023-08-14 | 2023-10-20 | 陕西科技大学 | External genitalia nursing spray and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109432204B (en) | 2021-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109078165A (en) | A kind of composition and the preparation method and application thereof for the nursing of women privates | |
| CN102697671B (en) | Bacterium and disease prevention wet wipe liquid medicament and preparation method thereof | |
| CN109106806A (en) | A kind of women secret nursing washing lotion and preparation method thereof | |
| US10478463B2 (en) | External-use medicament for cleaning and care of the ovaries, vagina, and vulva | |
| CN103316262B (en) | A kind of gynecological external antibacterial liquid and preparation method thereof | |
| CN103263525B (en) | Gynecological cleaning fluid and preparation method thereof | |
| CN109771368A (en) | A kind of bacteriostatic gel and preparation method thereof | |
| CN103463284B (en) | Gynecological cleaning liquid and preparation method thereof | |
| CN101797269B (en) | Physiological balance liquid for adjusting microecology in vaginas of women | |
| CN107184911A (en) | One kind is used to prevent cervical carcinoma and treatment papillomavirus（HPV）Infection and the product and preparation method of colpitis | |
| CN106728630A (en) | A kind of anti-inflammation composition and privates care product | |
| CN102397444A (en) | Nano-grade gynaecological lotion and preparation method thereof | |
| CN109316550A (en) | A kind of cleaning is antibacterial to use care agent | |
| CN109432204A (en) | A kind of silver ion is spraying and preparation method thereof | |
| CN104587033B (en) | A kind of Nano Silver rhinitis ointment | |
| CN102988844A (en) | Gynaecological gel and extraction method thereof | |
| CN105535723A (en) | Traditional Chinese medicinal composition for treating vulvitis and external preparation of traditional Chinese medicinal composition | |
| CN109602813A (en) | A kind of bacteriostatic gel and preparation method thereof | |
| CN105687021A (en) | Foot powder for preventing tinea pedis | |
| CN101757119B (en) | Medicine composition for treating vaginitis as well as gel and preparation method thereof | |
| CN107308104A (en) | A kind of preparation method of gynecological gel | |
| CN106344453A (en) | Novel acne cream and preparation method thereof | |
| CN105998974A (en) | Traditional Chinese medicine composition and gels for treating gynecologic inflammation and preparation method thereof | |
| CN106176916A (en) | A kind of vagina balance conditioning liquid | |
| CN110193004A (en) | Women bacteriostatic gel and preparation method thereof containing biological bacteriostatic peptide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |