CN109432204B

CN109432204B - Silver ion spray and preparation method thereof

Info

Publication number: CN109432204B
Application number: CN201811569206.0A
Authority: CN
Inventors: 黄彩仪; 林锦雄; 王丽辉
Original assignee: Guangzhou Aibei Biological Technology Co Ltd
Current assignee: Guangzhou Aibei Biological Technology Co Ltd
Priority date: 2018-12-20
Filing date: 2018-12-20
Publication date: 2021-07-27
Anticipated expiration: 2038-12-20
Also published as: CN109432204A

Abstract

The invention discloses silver ion spray which comprises the following components in percentage by weight: 0.2 to 1.5 percent of colloidal silver, 1.6 to 19 percent of antibacterial composition and 0.5 to 2 percent of collagen; the antibacterial composition comprises the following components in parts by weight: 0.5-5 parts of radix sophorae flavescentis extract, 0.5-5 parts of fructus cnidii extract, 0.2-3 parts of safflower extract, 0.2-3 parts of hairyvein agrimony extract and 0.2-3 parts of cortex dictamni extract. The silver ion spray disclosed by the invention is convenient to use, has excellent antibacterial performance and moisturizing performance, has an excellent inhibiting effect on staphylococcus aureus and other bacteria, candida albicans and trichomonas, so that gynecological diseases such as pudendum itch and inflammation are effectively prevented and relieved, private skin is kept moist after the silver ion spray is used, the pH balance of the private skin is favorably maintained, the private defense function is improved, the healing of damaged skin can be promoted, and the silver ion spray is safe, mild, non-irritant and good in nursing effect.

Description

Silver ion spray and preparation method thereof

Technical Field

The invention relates to a cosmetic, in particular to silver ion spray for nursing female private parts and a preparation method thereof.

Background

The private part is one of the important parts for female care, and gynecological diseases such as vaginitis, pelvic inflammation and the like can be easily induced by improper care. With the increasing health awareness of people, more and more women begin to pay attention to the maintenance and care of private parts. Currently, most women use commercially available personal cleansing solutions for personal care. Most of commercially available private cleaning solutions use chemical bacteriostatic agents, and after long-term use, the private cleaning solutions can destroy the pH value balance of private parts and prevent beneficial bacteria from growing, so that the natural defense function of the private parts is reduced, and pathogens are easy to invade. Once infected in private parts, pathogenic bacteria can be crazy to reproduce and grow, which causes gynecological diseases and even induces venereal diseases and infertility.

Vaginitis (vaginitis), which is a common gynecological disease, is a vaginitis, and about more than 70% of women suffer from vaginitis, which seriously affects the normal family life of patients. Common gynecological vaginitis comprises candidal vaginitis, trichomonas vaginitis and the like; candidal vaginitis is vaginal inflammation caused by candida albicans, and is clinically mainly manifested by burning pain of vulva, pruritus and leukorrhagia which are like bean dregs and are accompanied by urgent micturition, pain in urination, frequent micturition or restless sitting when serious; the trichomonas vaginitis is vaginitis caused by trichomonas, and clinically, patients mainly show that vaginal mucosa is inflamed and bright red, covered with a spot-shaped pseudomembrane, often accompanied with foam-like secretion, consciously experienced pruritus of different degrees, few people have burning sensation and the like. The clinical treatment usually adopts medicines, wherein conventional western medicines are widely applied to the clinical treatment, and although the conventional western medicines can effectively relieve related symptoms, the conventional western medicines are easy to repeatedly attack, so that the prognosis is poor.

Disclosure of Invention

The invention aims to solve the defects in the prior art and provide silver ion spray for nursing female private parts and a preparation method thereof. The silver ion spray has a remarkable inhibiting effect on common pathogenic bacteria and trichomonas causing vaginitis, can effectively prevent and relieve pudendum itch, inflammation and the like, has a good nursing effect, and does not damage the pH value balance of female pudendum.

In order to realize the purpose, the invention adopts the technical scheme that:

the silver ion spray comprises the following components in percentage by weight: 0.2 to 1.5 percent of colloidal silver, 1.6 to 19 percent of antibacterial composition and 0.5 to 2 percent of collagen; the antibacterial composition comprises the following components in parts by weight: 0.5-5 parts of radix sophorae flavescentis extract, 0.5-5 parts of fructus cnidii extract, 0.2-3 parts of safflower extract, 0.2-3 parts of hairyvein agrimony extract and 0.2-3 parts of cortex dictamni extract.

Silver is one of trace elements in human tissues, and trace silver is harmless to human bodies. The chemical structure of silver determines that the silver has higher catalytic capability, and the reduction potential of the silver in a high oxidation state is extremely high enough to generate atomic oxygen in the surrounding space. Atomic oxygen has strong oxidizing property and can sterilize, Ag can strongly attract sulfydryl (-SH) on protease in bacteria, the Ag can be rapidly combined with the sulfydryl (-SH) to make the protease lose activity, and the bacteria die, and when the bacteria are killed by the Ag, the Ag is dissociated from the bacteria corpses and then is contacted with other bacterial colonies. Silver ions are added into the spray, so that the method has the following advantages: 1. silver ions can replace chemical anticorrosive additives, so that no preservative is added in the spray, and the use safety of the spray is greatly improved; 2. other functional components in the spray are fresher and purer, and the functions can be more fully exerted; 3. can promote the healing of skin wounds and increase the repair function of damaged cells; 4. the moistening and penetrating efficacy of the spray is effectively improved, and the skin can absorb nutrient substances easily; 5. the spray naturally has the active defense function against bacteria and further directly inhibits the bacteria from invading the skin, and many uncomfortable symptoms caused by the bacteria damage to the skin and the mucous tissues of the body can be easily solved, such as skin allergy, inflammation, body odor inelegance, face sore, dandruff and the like. The colloidal silver used in the present invention is sold under the trade name "silver solution-B" and is available from Guangzhou Jinmairong Biotech limited.

The collagen has high moisture keeping effect, and is effective in activating skin and inducing tissue regeneration. Collagen is also the main binding substance in the connective tissue of the human body, has large molecular weight, has better moisture retention capacity than polyols, is mainly used for supporting cells, is particularly suitable for the physical therapy retention of the skin at the thinnest stage after the skin is subjected to cutin removal, and has good permeability.

According to the invention, a large number of creative researches show that when the colloidal silver, the antibacterial composition and the collagen are compounded according to the proportion, the silver ion spray has excellent antibacterial performance and moisturizing performance, and has an excellent inhibiting effect on staphylococcus aureus and other bacteria, candida albicans and trichomonas, so that gynecological diseases such as pudendum itch and inflammation are effectively prevented and relieved, after the silver ion spray is used, the private skin is kept moist, the pH balance of the pudendum is favorably maintained, the injured skin can be promoted to heal, and the silver ion spray is safe, mild, non-irritant and good in nursing effect.

In the antibacterial composition, radix Sophorae Flavescentis (SOPHORA FLAVESCENS) extract contains various alkaloids, has different inhibitory effects on various organisms and fungi, and has antibacterial and antiinflammatory effects. The sophora flavescens extract can effectively promote the generation of collagen, has the anti-aging effect, also has the good moisturizing and water-holding effects, and has the water replenishing function. Fructus Cnidii (CNIDIUM MONNIERI) extract has antifungal effect, and can be used for treating acute exudative dermatosis and nourishing skin. The Carthami flos (Carthamus TINCTORIUS) extract is natural pigment such as safflower yellow and safflower red extracted from Carthami flos, and is safe and edible. The Carthami flos extract has effects of promoting blood circulation, resisting inflammation and oxidation, and can be used for treating contact dermatitis, seborrheic dermatitis, pruritus and neurodermatitis. The herba et Gemma Agrimoniae extract has effects of promoting blood coagulation, resisting bacteria and parasite, and relieving inflammation. The cortex dictamni extract has the functions of clearing heat, eliminating dampness, dispelling wind and removing toxicity, and has different degrees of inhibition effects on various pathogenic bacteria. According to the invention, a large number of creative researches show that the sophora flavescens extract, the fructus cnidii extract, the safflower extract, the hairyvein agrimony extract and the cortex dictamni extract have a synergistic effect in the aspect of antibiosis when being compounded according to the proportion, so that the antibacterial composition has excellent inhibition effects on staphylococcus aureus, escherichia coli, candida albicans, trichomonas and the like.

Preferably, the silver ion spray comprises the following components in percentage by weight: 0.5-1.5 percent of colloidal silver, 10-15 percent of antibacterial composition and 0.5-1.5 percent of collagen. Experiments show that the silver ion spray prepared by the formula has better antibacterial and moisturizing effects.

Preferably, the silver ion spray comprises the following components in percentage by weight: 1% of colloidal silver, 12% of antibacterial composition and 1% of collagen. Experiments show that the silver ion spray prepared by the formula has the best antibacterial and moisturizing effects.

Preferably, the antibacterial composition comprises the following components in parts by weight: 2-4 parts of sophora flavescens extract, 2-4 parts of fructus cnidii extract, 1.5-2.5 parts of safflower extract, 1.5-2.5 parts of hairyvein agrimonia herb and bud extract and 1.5-2.5 parts of cortex dictamni extract. In this case, the antibacterial composition has a better inhibitory effect on pathogenic bacteria such as staphylococcus aureus, escherichia coli, candida albicans and the like.

Preferably, the antibacterial composition comprises the following components in parts by weight: 3 parts of radix sophorae flavescentis extract, 3 parts of fructus cnidii extract, 2 parts of safflower extract, 2 parts of hairyvein agrimony extract and 2 parts of cortex dictamni extract. At this time, the antibacterial composition has the best inhibitory effect on pathogenic bacteria such as staphylococcus aureus, escherichia coli, candida albicans and the like.

Preferably, the silver ion spray further comprises the following components in percentage by weight: 0.2 to 0.6 percent of thickening suspending agent and 1 to 10 percent of humectant. Preferably, the thickening and suspending agent is a mixture of gum arabic and xanthan gum, having the INCI name "gum arabic (and) xanthan gum", and the trade name "solatum^TMAX ", available from Baihabo, Inc., Guangzhou. Preferably, the humectant is 1, 3-butanediol.

Preferably, the silver ion spray consists of the following components in percentage by weight: 0.2-1.5 percent of colloidal silver, 1.6-19 percent of antibacterial composition, 0.5-2 percent of collagen, 0.2-0.6 percent of thickening suspending agent, 1-10 percent of humectant and the balance of deionized water.

Preferably, the silver ion spray consists of the following components in percentage by weight: 0.5 to 1.5 percent of colloidal silver, 10 to 15 percent of antibacterial composition, 0.5 to 1.5 percent of collagen, 0.2 to 0.6 percent of thickening suspending agent, 3 to 5 percent of humectant and the balance of deionized water.

Preferably, the silver ion spray consists of the following components in percentage by weight: 1% of colloidal silver, 12% of antibacterial composition, 1% of collagen, 0.4% of thickening suspending agent, 4% of humectant and the balance of deionized water.

Preferably, the preparation method of the silver ion spray comprises the following steps: and mixing the thickening suspending agent, the humectant and the deionized water, heating to 70-80 ℃, uniformly stirring, cooling to 40-45 ℃, adding the colloidal silver, the antibacterial composition and the collagen, and uniformly stirring.

The invention also provides a using method of the silver ion spray, which specifically comprises the following steps: after bathing, spraying a proper amount of silver ion spray on private parts, lightly massaging for 3-5 min to promote skin absorption, and then cleaning with clear water.

Compared with the prior art, the invention has the beneficial effects that: the silver ion spray disclosed by the invention is convenient to use, has excellent antibacterial performance and moisturizing performance, has an excellent inhibiting effect on staphylococcus aureus and other bacteria, candida albicans and trichomonas, so that gynecological diseases such as pudendum itch and inflammation are effectively prevented and relieved, private skin is kept moist after the silver ion spray is used, the pH balance of the private skin is favorably maintained, the private defense function is improved, the healing of damaged skin can be promoted, and the silver ion spray is safe, mild, non-irritant and good in nursing effect.

Detailed Description

To better illustrate the objects, aspects and advantages of the present invention, the present invention is further illustrated by the following examples. It should be understood that the embodiments of the present invention are only for illustrating the technical effects of the present invention, and are not intended to limit the scope of the present invention. In the examples, the methods used were all conventional methods unless otherwise specified.

Examples

Examples 1 to 9 are examples of silver ion sprays according to the present invention, and the formulations thereof are shown in table 1.

TABLE 1 silver ion spray formulations of examples 1 to 9 (in weight percent)

The preparation method of the silver ion spray of the above embodiment is as follows: mixing SOLAGUM^TMMixing AX, 1, 3-butanediol and deionized water, heating to 75 deg.C, stirring, cooling to 45 deg.C, sequentially adding silver solution-B, radix Sophorae Flavescentis extract, fructus Cnidii extract, Carthami flos extract, herba et Gemma Agrimoniae extract, cortex Dictamni Radicis extract and collagen, and stirring.

Comparative examples 1 to 5 provide silver ion sprays having the formulations shown in table 2.

TABLE 2 silver ion spray formulations for comparative examples 1 to 5 (in weight percent)

The method for preparing the silver ion spray of the above comparative example refers to the method for preparing the silver ion spray of the example.

First, stability test

The silver ion sprays of examples 1-9 were tested for stability. The method comprises the following steps: the silver ion sprays prepared in examples 1 to 9 were placed at different temperatures (48 ℃, room temperature, 5 ℃ and-18 ℃) respectively, and after one month, the presence or absence of a foreign body (including whether discoloration, precipitation, or delamination) was observed, and the results are shown in table 3.

Table 3 stability test results

Test conditions	48℃	At normal temperature	5℃	-18℃
					Example 1	No abnormal sample	No abnormal sample	No abnormal sample	No abnormal sample
Example 2	No abnormal sample	No abnormal sample	No abnormal sample	No abnormal sample
					Example 3	No abnormal sample	No abnormal sample	No abnormal sample	No abnormal sample
Example 4	No abnormal sample	No abnormal sample	No abnormal sample	No abnormal sample
					Example 5	No abnormal sample	No abnormal sample	No abnormal sample	No abnormal sample
Example 6	No abnormal sample	No abnormal sample	No abnormal sample	No abnormal sample
					Example 7	No abnormal sample	No abnormal sample	No abnormal sample	No abnormal sample
Example 8	No abnormal sample	No abnormal sample	No abnormal sample	No abnormal sample
					Example 9	No abnormal sample	No abnormal sample	No abnormal sample	No abnormal sample

The results in table 3 show that: the silver ion sprays of examples 1-9 had good stability.

Second, the silver ion sprays of examples 1 to 9 were loaded into spray bottles, and whether or not the liquid was uniformly discharged was observed by pressing the pump heads of the spray bottles, and the results are shown in table 4.

TABLE 4

Third, product bacteriostasis test

The silver ion sprays of examples 1 to 9 and comparative examples 1 to 5 were used as test samples, respectively, to perform the bacteriostatic test:

1. the test index bacteria comprise Escherichia coli, Candida albicans and Staphylococcus aureus;

2. preparation of bacterial suspension: inoculating the strain on a culture medium slant, washing off the lawn on the slant by using a phosphate buffer solution after culture, uniformly mixing, and counting to prepare a bacterial suspension meeting the requirement of bacterial content;

3. and (3) bacteriostatic test: adding 8mL of test sample (phosphate buffer solution as positive control group) and 0.1mL of bacterial suspension into a sterile test tube, and mixing uniformly for 20 min. 0.1mL of the well-mixed sample solution is inoculated into a sterile plate, immediately poured into an agar culture medium which is melted and cooled to 45 ℃ and mixed evenly. After solidification, placing each inoculation flat plate at 37 ℃ for culturing for 49 hours, observing the result, and calculating the bacteriostasis rate;

4. the calculation formula of the bacteriostatic rate is as follows: the bacteriostatic rate (%) was (average number of bacteria in positive control group-average number of bacteria in experimental group)/average number of bacteria in positive control group × 100%.

The test results are shown in table 5.

TABLE 5 results of the bacteriostatic test

The results in table 5 show that the silver ion spray provided by the embodiment of the invention has a good inhibitory effect on escherichia coli, staphylococcus aureus and candida albicans, and the silver ion spray provided by the invention can effectively prevent and relieve gynecological diseases such as pudendum itch and inflammation and can enhance the capability of resisting pathogenic bacteria of the pudendum when being used for nursing the private parts of women.

As can be seen from comparative examples 1 to 3, the component ratios of the antibacterial composition have an influence on the antibacterial performance of the spray, and the ratio of the sophora flavescens extract: fructus cnidii extract: safflower extract: extract of hairyvein agrimony: when the cortex dictamni extract is equal to 3:3:2:2:2, the antibacterial effect of the antibacterial composition is the best.

Comparing example 1, example 4, example 5, example 8 and example 9, it can be seen that the spray performance obtained in example 1 is the best, and therefore, the present invention takes example 1 as a preferred formulation.

Comparing example 1 with comparative examples 1 to 5, it can be seen that the absence of components of the antimicrobial composition has an effect on the performance of the spray, particularly on the inhibition of staphylococcus aureus and candida albicans. Therefore, the radix sophorae flavescentis extract, the fructus cnidii extract, the safflower extract, the hairyvein agrimonia herb and the cortex dictamni extract are compounded, have a synergistic effect in the aspect of antibiosis, and show excellent inhibition effects on staphylococcus aureus, escherichia coli and candida albicans.

Fourth, use case

1. The method comprises the following steps: 50 female patients were randomly selected, all patients found trichomonas confirmed diagnosis and were accompanied with strong itching symptoms from vaginal discharge, each patient used the spray of example 1 once a day, whether the itching symptoms of the patients improved was recorded every other week, and the vaginal discharge of the patients was taken for microscopic examination.

2. And (3) judging the curative effect:

and (3) curing: the pruritus symptom completely disappears, the white leucorrhea is reduced, and the vaginal secretion smear microscopy is negative.

Improvement: the pruritus symptom is obviously relieved, the leucorrhea is reduced, and the smear microscopy of vaginal secretion is negative.

And (4) invalidation: although the pruritus symptom is relieved, the smear microscopy of vaginal secretion is positive.

The effect was recorded and counted and the results are shown in table 6.

TABLE 6 therapeutic effects

	First week	Second week	The third week	The fourth side
					Cure of disease	6 examples of	17 example (c)	26 examples of	35 examples of
Improvement of life	34 examples of	29 examples of	23 example(s)	15 examples of
					Invalidation	10 examples of	4 examples of	Example 1	0

As can be seen from the results in table 6, the silver ion spray of example 1 had a better therapeutic effect on female vaginitis, with improvement in almost all patients in the second week and improvement in all patients in the fourth week.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. The silver ion spray is characterized by comprising the following components in percentage by weight: 0.5-1.5% of colloidal silver, 10-15% of an antibacterial composition, 0.5-1.5% of collagen, 0.2-0.6% of a thickening suspending agent, 3-5% of a humectant and the balance of deionized water; the antibacterial composition comprises the following components in parts by weight: 3 parts of radix sophorae flavescentis extract, 3 parts of fructus cnidii extract, 2 parts of safflower extract, 2 parts of hairyvein agrimony extract and 2 parts of cortex dictamni extract.

2. The silver ion spray of claim 1, wherein said thickening suspending agent is a mixture of gum arabic and xanthan gum.

3. The silver ion spray of claim 1, wherein the humectant is 1, 3-butanediol.

4. The silver ion spray of claim 1, wherein the silver ion spray is comprised of the following components in weight percent: 1% of colloidal silver, 12% of antibacterial composition, 1% of collagen, 0.4% of thickening suspending agent, 4% of humectant and the balance of deionized water.

5. The method of preparing a silver ion spray according to any one of claims 1 to 4, comprising the steps of: and mixing the thickening suspending agent, the humectant and the deionized water, heating to 70-80 ℃, uniformly stirring, cooling to 40-45 ℃, adding the colloidal silver, the antibacterial composition and the collagen, and uniformly stirring.