CN107583050A - A kind of pharmaceutical composition and purposes for being used to treat cervicitis - Google Patents
A kind of pharmaceutical composition and purposes for being used to treat cervicitis Download PDFInfo
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- CN107583050A CN107583050A CN201711010986.0A CN201711010986A CN107583050A CN 107583050 A CN107583050 A CN 107583050A CN 201711010986 A CN201711010986 A CN 201711010986A CN 107583050 A CN107583050 A CN 107583050A
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- pharmaceutical composition
- ala
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Abstract
The present invention relates to a kind of pharmaceutical composition and purposes for being used to treat cervicitis, the effective active composition of described pharmaceutical composition is nano SiO 2 particle, 5 aminolevulinic acids or derivatives thereof and Resina Draconis polyphenol.Innovative combine 5 aminolevulinic acids or derivatives thereof, Resina Draconis polyphenol and nano SiO 2 particle of the invention is used as active constituents of medicine, using topical therapy cervical erosion, there is Synergistic, it is high to the cure rate of cervicitis and uneasy to recur.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of pharmaceutical composition and purposes for being used to treat cervicitis.
Background technology
Womb neck is in faintly acid under normal circumstances, and the acid-base value of vaginal fluid is pH=3.8-4.5, Ye Shicheng
Acidity, it can so be used for sterilizing and preventing cervical infection.However, insalubrious germ can also be grown in the ring of weak base
In border, therefore when cervical orifice is in alkalescent, these insalubrious germs are just concentrated in cervical orifice, now, pathology
When property microbial activities is around cervix, endotoxin and exotoxin can be secreted, and these toxin can dissolve the skin of cervical orifice
Skin appearance, therefore produce related secretion.
And to be generally discovery have cervicitis that the dense shape secretion of yellow flows out from cervix, the column epidermis in cervix
Also seem the especially fragile and easy congested , Tong Time of redness also easy bleedings.Furthermore if acute cervicitis breaks out, it can go out
Now substantial amounts of leukorrhea, orange or yellow green, milk sample, thick sexual secretion is even presented, causes peculiar smell, pain discomfort or itch etc.
Symptom.
In general, cervicitis pathogen includes Chlamydia, diplococcus, belongs to the normal bacterium colony (NORMAL of vagina
FLORA staphylococcus, streptococcus and Escherichia coli) etc., therapeutic modality common at present is based on antibiosis extract for treating, typically
Antibiotic and anti inflammation and heat resolution medicine can be given when treatment simultaneously according to the situation of inflammation, at the same bestow again vaginal disinfection,
The processing of local treatment, such as with liquid medicine lavation, but be easy to be infected again after treating recovery from illness, and the disease in low human body gradually
Opportunistic pathogen develops immunity to drugs, so that can not cure completely.
The physical treatment used at present all uses the practice of destruction of all people good and bad alike, is burnt using electricity, freezing or radium-shine that cervix is thin
Born of the same parents kill together with pathogen such as the Chlamydias in it, and so newly longer cell is exactly normal FFI cell.
Cervix erosion is the most common local patholoic change of cervicitis, neighbouring in the case where inflammatory disorderses slightly weaken
Galandular epithelium is gradually elapsed, finally covered completely by scaly epithelium to growing under the columnar epithelium for covering rotten to the corn face by scaly epithelium
And fully recover, although it is this by the situation that scaly epithelium directly substitutes in the presence of, it is indirect substitute it is more common, i.e., in columnar epithelium
Under be commonly present the less round cell of a line, claim basal cell or thesocyte, these cells increase in the agglutination of erosion
It is raw, finally it is divided into scaly epithelium.Rotten to the corn healing is in often piece block distribution, and because this newborn scaly epithelium is grown on inflammation
Property tissue on the basis of, therefore cells of superficial layer easily comes off and thinning, slightly stimulated to recover rotten to the corn again, therefore, healing and inflammation
Extension alternately occur, treatment it is not thorough, it is extremely difficult to fully recover.
The content of the invention
In view of the above-mentioned problems, the invention provides a kind of pharmaceutical composition for being used to treat cervicitis, the pharmaceutical composition
Can solve the problems, such as that current drug therapy cervicitis curative effect is poor, be difficult to cure completely.
The technical scheme that the present invention takes is as follows：
One aspect of the present invention provides a kind of pharmaceutical composition, and the effective active composition of described pharmaceutical composition is titanium dioxide
Nano silicon particles, 5-ALA or derivatives thereof and Resina Draconis polyphenol.
Further, in terms of parts by weight, in described pharmaceutical composition, nano SiO 2 particle 50-100 parts, 5- ammonia
Base ketone valeric acid or derivatives thereof 5-15 parts, Resina Draconis polyphenol 2-10 parts.
Further, the particle diameter of the nano SiO 2 particle is 40-50nm.
Further, the preparation of described pharmaceutical composition is solution, suppository or gel.
Further, the gel for the effective active composition is mixed with gel-type vehicle, auxiliary material and deionized water and
Into.
Further, the gel-type vehicle is selected from hydroxymethyl cellulose, carbomer, chitosan derivatives, polycarbophil, wood
One or more in sugared glucan or sodium alginate.
Further, the auxiliary material is in thickener, antioxidant, stabilizer, surfactant, preservative or antiseptic
One or more.
Further, the preparation is vagina administration preparation.
Present invention also offers a kind of pharmaceutical composition as described above to prepare the application in treating cervicitis medicine.
In the pharmaceutical composition of the present invention, Resina Draconis polyphenol has promoting blood circulation to remove blood stasis, analgesic therapy hemostasis, holds back wound promoting muscle growth functions.Also
Proliferation, Differentiation and the secretion of Skin Cell can be promoted, and promote capillary to regenerate, blood supply increase, and then promotion organization work
The reparation of the journey skin-on-skin surface of a wound.Resina Draconis polyphenol, which is applied, to be spread at the local erosion of uterine neck, and energy can be provided for human body cell, is tieed up
The normal function of human body cell is held, and can suppresses the breeding of common microbiological, dies of hunger bacterium.
In the pharmaceutical composition of the present invention, 5-aminolevulinic acid and its derivative are conventional Visudynes,
The product of listing includes ALA, 5-ALA methyl esters and the own ester of 5-ALA.Into human body
After be converted into haematoporphyrin and be detained internal, active oxygen such as singlet oxygen and other free radicals are produced after the illumination of specific wavelength
And pathogenic cell (cancer cell, the cell of human papilloma virus and herpes simplex infections, wart body cell) is killed, and close on
Normal tissue cell be not affected.Clinically 5-aminolevulinic acid and its derivative are used to treating acne, sharp wet
A variety of diseases such as the epithelial squamous cell knurl sample of wart, actinic keratoma, cervical carcinoma and vagina and uterus neck change.
Patent CN101829144B reports nano SiO 2 particle answering in the medicine for preparing treatment cervicitis
With, but do not appeared in the newspapers on the effect of nano SiO 2 particle and other chemicals therapeutic alliance cervicitis, this hair
It is bright it is innovative by Resina Draconis polyphenol, 5-aminolevulinic acid and its derivative and nano SiO 2 particle joint be used as medicine
Active component, using topical therapy cervicitis, there is Synergistic, it is high to the cure rate of cervicitis and be not easy
Recurrence.
The nano SiO 2 particle of the present invention not only can be with Resina Draconis polyphenol and 5-ALA or derivatives thereof
Compounding, compounding can also be carried out with medically conventional Chinese medicine or other Western medicine and form the medicine for being used for treating cervicitis.Two
The principle of silica super nano particle absorption pathogen is：The size of the nano SiO 2 particle is about 40-50 nanometers, remote small
In virus, and the separation when being dissolved in solvent between each nano SiO 2 particle is very big, and titanium dioxide when being dissolved in solvent
Nano silicon particles can form the net such as fishing, and pathogen and secretion absorption are caught, and after pathogen is captured just not
Come is discharged by the silica dioxide granule again, therefore can effectively cure cervicitis.
Meanwhile the nano SiO 2 particle is in 48 hours release EB elementary bodies of pathogen-Chlamydia of cervicitis
When, viral adsorption is come with its distinctive structure (fishing net structure) so that the time of cervicitis treatment shortens, and can root
Control the cervicitis.
Furthermore the nano SiO 2 particle is extracted from plant, will not be expanded, energy viral adsorption, there is security,
Chemical action is not susceptible to simultaneously, will not also dissolve generation toxicity；And because the separation between nano SiO 2 particle is very big,
Moisture content will not be first adsorbed, the pathogen and its toxicity for effectively making cervicitis are concentrated, and can effectively adsorb pathogenic pathogen,
Microorganism beneficial in vivo is also remained simultaneously.
Embodiment
Embodiments of the present invention are described in detail below with reference to embodiment, and illustrated embodiment is served only for explaining this hair
It is bright, it is not intended to limit the scope of the present invention.
The experimental method of unreceipted actual conditions in the following example, generally according to normal condition, or according to manufacturer
Proposed condition.
Involved other drugs or auxiliary material are commercial goods in the embodiment of the present invention, described silica nanometer
Grain is that specific preparation method is as follows with reference to made from Application No. CN86104705 Chinese patent：
First husk or straw layering are positioned in kiln, and breather pipe is provided with each layer, the ventilation tube wall is provided with small
Hole；It is not required to add other fuel in the kiln, the roasting of husk or straw is entirely using contained by per kilogram husk or straw
The upper heats of 3500-4000 are successively ignited, and roasting controls through the air capacity that breather pipe is discharged and entered in kiln, by kiln
Temperature control is below 600 DEG C.
After the completion of roasting, 60-90 minutes are handled using watery hydrochloric acid or dilute sulfuric acid, and rush using distilled water or ion exchange water
Wash, remove the oxide impurities such as magnesia, sodium oxide molybdena, calcium oxide and potassium oxide contained in product, after drying, use air-flow
Pulverizer will lump solution it is broken, you can obtain content be 92-95% white amorphous silica nano particle.
The nano SiO 2 particle made from this method by purification, obtains the silica nanometer that concentration is 99% again
Particle.
Embodiment 1
Formula composition：Resina Draconis polyphenol 5g, ALA acid sodium 7.5g, nano SiO 2 particle 50g, card ripple
Nurse 1g, methyl p-hydroxybenzoate 0.08g, triethanolamine 0.2g, propane diols 0.5g, deionized water add to 200g.
Preparation process：Weigh carbomer 1g and be scattered in 100g deionized waters and be swelled 24h, add triethanolamine and adjust pH value
To 4.0-5.0, solution A is obtained；With appropriate warm water dissolving methyl p-hydroxybenzoate 0.08g, propane diols 0.5g, Resina Draconis polyphenol
5g, ALA acid sodium 7.5g, nano SiO 2 particle 50g, and be slowly added into solution A, add deionized water
To 200g, stir and produce medicament gelling agent.
Embodiment 2
Formula composition：Resina Draconis polyphenol 4g, ALA acid sodium 6g, nano SiO 2 particle 30g, carbomer
0.8g, methyl p-hydroxybenzoate 0.06g, triethanolamine 0.2g, propane diols 0.4g, deionized water add to 200g.
Preparation process：Weigh carbomer 0.8g and be scattered in 100g deionized waters and be swelled 24h, add triethanolamine and adjust pH
Value obtains solution A to 4.0-5.0；With appropriate warm water dissolving methyl p-hydroxybenzoate 0.06g, propane diols 0.4g, Resina Draconis polyphenol
4g, ALA acid sodium 6g, nano SiO 2 particle 30g, and be slowly added into solution A, addition deionized water is extremely
200g, stir and produce medicament gelling agent.
Embodiment 3
Formula composition：Resina Draconis polyphenol 3g, ALA acid sodium 4g, nano SiO 2 particle 20g, carbomer
0.6g, methyl p-hydroxybenzoate 0.04g, triethanolamine 0.2g, propane diols 0.3g, deionized water add to 200g.
Preparation process：Weigh carbomer 0.6g and be scattered in 100g deionized waters and be swelled 24h, add triethanolamine and adjust pH
Value obtains solution A to 4.0-5.0；With appropriate warm water dissolving methyl p-hydroxybenzoate 0.04g, propane diols 0.3g, Resina Draconis polyphenol
3g, ALA acid sodium 4g, nano SiO 2 particle 20g, and be slowly added into solution A, addition deionized water is extremely
200g, stir and produce medicament gelling agent.
Comparative example 1
Formula composition：Resina Draconis polyphenol 10g, carbomer 1g, methyl p-hydroxybenzoate 0.08g, triethanolamine 0.2g, third
Glycol 0.5g, deionized water add to 200g.
Preparation process：Weigh carbomer 1g and be scattered in 100g deionized waters and be swelled 24h, add triethanolamine and adjust pH value
To 4.0-5.0, solution A is obtained；With appropriate warm water dissolving methyl p-hydroxybenzoate 0.08g, propane diols 0.5g, Resina Draconis polyphenol
10g, and be slowly added into solution A, addition deionized water stirs to 200g and produces medicament gelling agent.
Comparative example 2
Formula composition：ALA acid sodium 15g, carbomer 1g, methyl p-hydroxybenzoate 0.08g, three ethanol
Amine 0.2g, propane diols 0.5g, deionized water add to 200g.
Preparation process：Weigh carbomer 1g and be scattered in 100g deionized waters and be swelled 24h, add triethanolamine and adjust pH value
To 4.0-5.0, solution A is obtained；With appropriate warm water dissolving methyl p-hydroxybenzoate 0.08g, propane diols 0.5g, 5-ALA
Hydrochloric acid sodium 15g, and be slowly added into solution A, addition deionized water stirs to 200g and produces medicament gelling agent.
Comparative example 3
Formula composition：Nano SiO 2 particle 100g, carbomer 1g, methyl p-hydroxybenzoate 0.08g, triethanolamine
0.2g, propane diols 0.5g, deionized water add to 200g.
Preparation process：Weigh carbomer 1g and be scattered in 100g deionized waters and be swelled 24h, add triethanolamine and adjust pH value
To 4.0-5.0, solution A is obtained；With appropriate warm water dissolving methyl p-hydroxybenzoate 0.08g, propane diols 0.5g, silica nanometer
Particle 100g, and be slowly added into solution A, addition deionized water stirs to 200g and produces medicament gelling agent.
Experimental example
25-45 year women of multidigit gynecatoptron analysis showed different cervical erosion is chosen, before start of the treatment, is adopted
Analyze each patient's cervical erosion degree with gynecatoptron, according to gynecatoptron photo and may with inflammation seriousness, to by
Examination patient is classified according to routine cervical pathological classification, and hierarchy plan is as follows：
1st grade：, there is mottled disease damage and dystopy in pure cervicitis, leukorrhea is reduced, without dyspareunia (sexual intercourse
When allodynic)；
2nd grade：, the epithelium changed be present in Cervicitis with erosion Extensive site (30% surface)：Accident hemorrhage and
Accidental dyspareunia；
3rd level：, dystopy, frequent bleeding, leukorrhea and sexual intercourse be present in Cervicitis with erosion Extensive site (50% surface)
It is difficult.
After classification, be divided into by classification results 1 grade in 6 groups, every group, 2 grades, 3 grades of patients be 10 people, wherein the 1st group is applied
The medicament gelling agent prepared with embodiment 1, the 2nd group is applied medicament gelling agent prepared by embodiment 2, and the 3rd group is made using embodiment 3
Standby medicament gelling agent, the 4th group is applied medicament gelling agent prepared by comparative example 1, is applied medicine prepared by comparative example 2 for the 5th group and is coagulated
Jelly, the 6th group is applied medicament gelling agent prepared by comparative example 3.Each patient daily in night medication once, continuous use six
My god.After local treatment terminates, each patient's cervical erosion degree is analyzed again using gynecatoptron.Test result is as shown in table 1：
The vaginoscopy result of table 1
As it can be seen from table 1 using the pharmaceutical composition of the present invention, cervix erosion degree drops patient significantly after the treatment
Low, 1 grade of patient numbers is increased to 24 people, 23 people and 22 people respectively by 10 original people, and 3 grades of erosion patients are by 10 original people point
1 people, 1 people and 2 people are not reduced to.And lived only with nano SiO 2 particle, ALA or dragon's blood polyphenol
Property component, 1 grade of patient increases number and 3 grades of patients reduce numbers less than the present invention, illustrates that the pharmaceutical composition of the present invention exists
There is extraordinary curative effect in terms for the treatment of cervical erosion.And from table 1 it can also be seen that nano SiO 2 particle and 5- amino ketones
Valerate hydrochlorate, the combination of Resina Draconis polyphenol have a synergistic function, and the effect that three shares is more independent than any of which component
The effect sum used is more preferable.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (10)
- A kind of 1. pharmaceutical composition for being used to treat cervicitis, it is characterised in that the effective active composition of described pharmaceutical composition For nano SiO 2 particle, 5-ALA or derivatives thereof and Resina Draconis polyphenol.
- 2. pharmaceutical composition according to claim 1, it is characterised in that in terms of parts by weight, described pharmaceutical composition bag Include nano SiO 2 particle 50-100 parts, 5-ALA or derivatives thereof 5-15 parts, Resina Draconis polyphenol 2-10 parts.
- 3. pharmaceutical composition according to claim 1 or 2, it is characterised in that the particle diameter of the nano SiO 2 particle For 40-50nm.
- 4. pharmaceutical composition according to claim 1 or 2, it is characterised in that the 5-ALA derivative is selected from ALA, 5-ALA sulfate, 5-ALA succinate, 5-ALA methyl esters or One kind in the own ester of 5-ALA.
- 5. pharmaceutical composition according to claim 1 or 2, it is characterised in that the formulation of described pharmaceutical composition is solution Agent, suppository or gel.
- 6. medicine according to claim 5, it is characterised in that the gel is the effective active composition and gel base Matter, auxiliary material and deionized water mix.
- 7. medicine according to claim 6, it is characterised in that the gel-type vehicle be selected from hydroxymethyl cellulose, carbomer, One or more in chitosan derivatives, polycarbophil, xyloglucan or sodium alginate.
- 8. medicine according to claim 6, it is characterised in that the auxiliary material is thickener, antioxidant, stabilizer, table One or more in face activating agent, preservative or antiseptic.
- 9. according to the medicine described in claim any one of 6-8, it is characterised in that the preparation is vagina administration preparation.
- 10. the medicine as described in claim any one of 1-9 is preparing the application in treating cervicitis medicine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711010986.0A CN107583050A (en) | 2017-10-26 | 2017-10-26 | A kind of pharmaceutical composition and purposes for being used to treat cervicitis |
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| CN201711010986.0A CN107583050A (en) | 2017-10-26 | 2017-10-26 | A kind of pharmaceutical composition and purposes for being used to treat cervicitis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618596A (en) * | 2021-01-19 | 2021-04-09 | 山东百奥生物医药有限公司 | Bacteriostatic and antiviral gel capable of observing focus area and preparation method and application thereof |
-
2017
- 2017-10-26 CN CN201711010986.0A patent/CN107583050A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618596A (en) * | 2021-01-19 | 2021-04-09 | 山东百奥生物医药有限公司 | Bacteriostatic and antiviral gel capable of observing focus area and preparation method and application thereof |
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