CN107913394A - A kind of koro gel containing nano-silver ionic - Google Patents

A kind of koro gel containing nano-silver ionic Download PDF

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Publication number
CN107913394A
CN107913394A CN201711176499.1A CN201711176499A CN107913394A CN 107913394 A CN107913394 A CN 107913394A CN 201711176499 A CN201711176499 A CN 201711176499A CN 107913394 A CN107913394 A CN 107913394A
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extract
koro
nano
silver
gel containing
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路书刚
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Suzhou Ancestral Hall Of Nano Science And Technology Co Ltd
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Suzhou Ancestral Hall Of Nano Science And Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738—Rosa (rose)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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Abstract

The invention discloses a kind of koro gel containing nano-silver ionic.The technical scheme is that：A kind of koro gel containing nano-silver ionic, including following components by mass percentage：Glycerine 5.0 10.0%, propane diols 3.0 10.0%, carbomer 1.0 3.0%, triethanolamine 0.4 0.6%, blue copper wins peptide 0.0 10.0%, hyaluronic acid 0.05 0.2%, watermiscible vitamin E 0.0 2.0%, niacinamide 0.0 5.0%, gadol extract 0.0 5.0%, camomile extract 0.0 5.0%, Leonurus extract 0.0 6.0%, medicinal and edible plant extract 1.0 36.0%, remaining is micro/nano trivalent silver iron compound and water.Scheme koro restoration care effect provided by the invention is good and irritation is small, effect stability, and rebound rate is low.

Description

A kind of koro gel containing nano-silver ionic
Technical field
The present invention relates to medical and sanitary products field, more particularly to a kind of koro gel containing nano-silver ionic.
Background technology
It is more to be presently used for the antibacterial anti-inflammatory class Western medicine product species such as treatment female vagina, cervicitis, as people give birth to The flat raising of running water, to improve life quality, the Western medicine product of the vagina contraction used for women has also come out and has used.By Chemicals in Western medicine, side effect in use is larger, and irritation is stronger, the Western medicine product of vagina contraction integrally in bar-shaped, Intravaginal is inserted into during use, vagina contraction effect is unstable, and after pharmacological property, rebound rate is high.
In the prior art, vagina mucosa restoration care component uses some western medicine compositions such as heparin sodium, chlorpheniramine, profit mostly More cacaines etc., it is larger to vaginal mucosa irritation；Also some non-integration of drinking and medicinal herbs medicinal herb components such as radix scutellariae, iron sheet stone can be added Bucket, kuh-seng, frutus cnidii, the tuber of stemona, Cortex Phellodendri etc., these also have vagina mucosa certain irritation.In addition, the prior art is coagulated Even if bland medicinal herb components are added in the selection of glue medial vagina cell migration nursing compositions, what is also added is Chinese herbal medicine extraction Liquid, active constituent content very little, restoration care effect are very bad.And integration of drinking and medicinal herbs medicinal herb components powder, it is usually direct The situation of vagina externally applied drug in oral drug, particularly treating gynecological disease for externally applied drug is but rarely reported.
The content of the invention
In view of the deficienciess of the prior art, it is a primary object of the present invention to provide, a kind of irritation is small and restoration care The good koro gel containing nano-silver ionic of effect.
To achieve the above object, the present invention provides following technical solution：A kind of koro gel containing nano-silver ionic, Including following components by mass percentage：Glycerine 5.0-10.0%, propane diols 3.0-10.0%, carbomer 1.0-3.0%, three Monoethanolamine 0.4-0.6%, blue copper win peptide 0.0-10.0%, hyaluronic acid 0.05-0.2%, watermiscible vitamin E 0.0-2.0%, nicotinoyl Amine 0.0-5.0%, gadol extract 0.0-5.0%, camomile extract 0.0-5.0%, Leonurus extract 0.0-6.0%, medicine Homologous plant extract 1.0-36.0% is eaten, remaining is micro/nano trivalent silver iron compound and water.
Preferably, the medicinal and edible plant extract further includes Honegsukle flower P.E, Flos Chrysanthemi Indici extract, rose and carries The one or more in thing, Gotu Kola P.E, mint extract, aloe extract are taken, any one medicinal and edible plant Extract accounts for the mass percent of gynecological gel gross mass in 7 below .0%.
Preferably, the koro gel includes following components by mass percentage：Glycerine 10.0%, propane diols 5.0%, Carbomer 1.0%, triethanolamine 0.4%, blue copper win peptide 3.0%, hyaluronic acid 0.1%, watermiscible vitamin E 1.0%, niacinamide 2.0%, gadol extract 2.0%, camomile extract 2.0%, Leonurus extract 5.0%, medicinal and edible plant extract 30.0%, micro/nano trivalent silver iron compound and water, the dosage of the micro/nano trivalent silver iron compound are to make koro gel The concentration of middle silver ion is the dosage of 3 .0ppm.
Preferably, the medicinal and edible plant extract includes following components by mass percentage：Honeysuckle carries Take thing 6.0%, Flos Chrysanthemi Indici extract 5.0%, Flos Rosae Rugosae extract 5.0%, Gotu Kola P.E 6.0%, mint extract 5.0%, reed Luxuriant growth extract 3.0%.
Preferably, the preparation method of the micro/nano trivalent silver iron compound is as follows：Weigh in proportion containing the anti-of silver Substrate is answered, is fully ground uniformly mixed；(2) deionized water is added, is tuned into rheology state；(3) constant temperature is kept for certain time；(4) mistake Filter, it is clean with pure water rinsing, unreacted material is washed away, that is, obtains micro/nano trivalent silver iron compound.
The present invention has the following advantages that the present invention uses silver ion antimicrobial agent relative to the prior art, is somebody's turn to do when human body uses After gel, remained in vivo without the nano-carrier of nano silver, so it is fool proof；After use also no fungicide bring it is residual Profit retention point excludes, into without any carrying capacity of environment, so that the problem of without the health for influencing environment and people that may be brought； There is no the critical defect that the antiseptics such as aldehydes, acids, chlorinated product are big to vagina mucosa, skin irritation.This formula technique is invented Overcome that traditional and existing formula technique brings completely to mucocutaneous irritation and product efficacy in terms of it is undesirable Defect.Scheme koro restoration care effect provided by the invention is good and irritation is small, effect stability, and rebound rate is low.
Embodiment
The invention will be further described below.
A kind of koro gel containing nano-silver ionic, including following components by mass percentage：Glycerine 5.0- 10.0%, propane diols 3.0-10.0%, carbomer 1.0-3.0%, triethanolamine 0.4-0.6%, blue copper victory peptide 0.0-10.0% are transparent Matter acid 0.05-0.2%, watermiscible vitamin E 0.0-2.0%, niacinamide 0.0-5.0%, gadol extract 0.0-5.0%, ocean are sweet Chrysanthemum extract 0.0-5.0%, Leonurus extract 0.0-6.0%, medicinal and edible plant extract 1.0-36.0%, remaining is micro-nano Rice trivalent silver iron compound and water.The present invention uses micro/nano trivalent silver iron compound, after human body uses the gel, does not have The nano-carrier for having nano silver remains in vivo, and then fool proof；The residual component row that also no fungicide is brought after use Remove, into without any carrying capacity of environment, so that the problem of without the health for influencing environment and people that may be brought；There is no aldehyde The antiseptics such as class, acids, the chlorinated product critical defect big to vagina mucosa, skin irritation.This formula technique invents complete gram Taken that traditional and existing formula technique brings to mucocutaneous irritation and product efficacy in terms of it is undesirable the defects of.Contracting Cloudy restoration care effect is good and irritation is small.
Further, the medicinal and edible plant extract further includes Honegsukle flower P.E, Flos Chrysanthemi Indici extract, rose One or more in extract, Gotu Kola P.E, mint extract, aloe extract, any one integration of drinking and medicinal herbs are planted Thing extract accounts for the mass percent of gynecological gel gross mass in 7 below .0%.
Preferably, the koro gel includes following components by mass percentage：Glycerine 10.0%, propane diols 5.0%, Carbomer 1.0%, triethanolamine 0.4%, blue copper win peptide 3.0%, hyaluronic acid 0.1%, watermiscible vitamin E 1.0%, niacinamide 2.0%, gadol extract 2.0%, camomile extract 2.0%, Leonurus extract 5.0%, medicinal and edible plant extract 30.0%, micro/nano trivalent silver iron compound and water, the dosage of the micro/nano trivalent silver iron compound are to make koro gel The concentration of middle silver ion is the dosage of 3 .0ppm.
Preferably, the medicinal and edible plant extract includes following components by mass percentage：Honeysuckle carries Take thing 6.0%, Flos Chrysanthemi Indici extract 5.0%, Flos Rosae Rugosae extract 5.0%, Gotu Kola P.E 6.0%, mint extract 5.0%, reed Luxuriant growth extract 3.0%.
The koro gel of the present invention can be used for vagina, play clean cool, sterilizing and itch-relieving, convergence koro, reparation Light moderate cervical erosion/fibroid and treatment pelvic infecton/tumour/Trichomonas vaginalis and koro of compacting/palace cold dysmenorrhoea irregular menstruation Deng gynecological disease, and guard against cross infection, the effect of privacy places is repaired in health care maintenance.It is generally filling as koro gel Used in disposable tailormadepiston syringe pipe, play clean cool, sterilizing and itch-relieving, treatment acne, the effect of hemorrhoid.
Preferably, the preparation method of the micro/nano trivalent silver iron compound is as follows：Weigh in proportion containing the anti-of silver Substrate is answered, is fully ground uniformly mixed；(2) deionized water is added, is tuned into rheology state；(3) constant temperature is kept for certain time；(4) mistake Filter, it is clean with pure water rinsing, unreacted material is washed away, that is, obtains micro/nano trivalent silver iron compound.In rheology phase system In, solia particle is evenly distributed, is in close contact in a fluid, its surface energy accesses effective utilization, and reaction carries out more Fully, product recoveries are high, synthesizing efficient.The volume ratio of product and reaction vessel is very high, can be to avoid the big volume production of discarded object It is raw, it is good for the environment, is a kind of efficient, energy saving, economic, environmental-friendly green production process.Each several part in fluid Exchange good, heat transfer, mass transfer are stablized, can be to avoid hot-spot, and easy control of temperature can obtain uniformity particle Micro Nano material.
The above is only the preferred embodiment of the present invention, and protection scope of the present invention is not limited merely to above-mentioned implementation Example, all technical solutions belonged under thinking of the present invention belong to protection scope of the present invention.It should be pointed out that for the art Those of ordinary skill for, some improvements and modifications without departing from the principles of the present invention, these improvements and modifications It should be regarded as protection scope of the present invention.

Claims (5)

1. a kind of koro gel containing nano-silver ionic, it is characterised in that including following components by mass percentage：It is sweet Oily 5.0-10.0%, propane diols 3.0-10.0%, carbomer 1.0-3.0%, triethanolamine 0.4-0.6%, blue copper victory peptide 0.0- 10.0%, hyaluronic acid 0.05-0.2%, watermiscible vitamin E 0.0-2.0%, niacinamide 0.0-5.0%, gadol extract 0.0- 5.0%, camomile extract 0.0-5.0%, Leonurus extract 0.0-6.0%, medicinal and edible plant extract 1.0-36.0%, its Remaining is micro/nano trivalent silver iron compound and water.
A kind of 2. koro gel containing nano-silver ionic according to claim 1, it is characterised in that the integration of drinking and medicinal herbs Plant extracts further includes Honegsukle flower P.E, Flos Chrysanthemi Indici extract, Flos Rosae Rugosae extract, Gotu Kola P.E, peppermint extraction One or more in thing, aloe extract, any one medicinal and edible plant extract account for the matter of gynecological gel gross mass Percentage is measured in 7 below .0%.
A kind of 3. koro gel containing nano-silver ionic according to claim 1, it is characterised in that the koro gel Including following components by mass percentage：Glycerine 10.0%, propane diols 5.0%, carbomer 1.0%, triethanolamine 0.4% are blue Copper wins peptide 3.0%, hyaluronic acid 0.1%, watermiscible vitamin E 1.0%, niacinamide 2.0%, gadol extract 2.0%, chamomile Extract 2.0%, Leonurus extract 5.0%, medicinal and edible plant extract 30.0%, micro/nano trivalent silver iron compound and Water, the dosage of the micro/nano trivalent silver iron compound are to make the dosage that the concentration of silver ion in koro gel is 3 .0ppm.
A kind of 4. koro gel containing nano-silver ionic according to claim 3, it is characterised in that the integration of drinking and medicinal herbs Plant extracts includes following components by mass percentage：Honegsukle flower P.E 6.0%, Flos Chrysanthemi Indici extract 5.0%, rose Rare flower extract 5.0%, Gotu Kola P.E 6.0%, mint extract 5.0%, aloe extract 3.0%.
5. a kind of koro gel containing nano-silver ionic according to claim 1, it is characterised in that described micro-nano three The preparation method of valency silver iron compound is as follows：The reaction substrate containing silver is weighed in proportion, is fully ground uniformly mixed；(2) Deionized water is added, is tuned into rheology state；(3) constant temperature is kept for certain time；(4) filter, it is clean with pure water rinsing, wash away not anti- The material answered, that is, obtain micro/nano trivalent silver iron compound.
CN201711176499.1A 2017-11-22 2017-11-22 A kind of koro gel containing nano-silver ionic Pending CN107913394A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111450189A (en) * 2020-04-10 2020-07-28 孙笑笑 Gene extraction vagina contracting liquid
CN113908206A (en) * 2021-10-14 2022-01-11 湖南伟方生命科技有限公司 Preparation method and application of gynecological antibacterial gel

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Publication number Priority date Publication date Assignee Title
CN101773520A (en) * 2010-03-05 2010-07-14 沈作兵 Compound antimicrobial containing polyvalent silver ions and preparation method thereof
CN101857262A (en) * 2010-06-18 2010-10-13 苏州邦安新材料科技有限公司 Novel micro/nano trivalent silver iron compound synthesizing method
CN106109534A (en) * 2016-08-23 2016-11-16 广州洁康卫生用品有限公司 The antipruritic repair liquid of silver ion antibacterial, preparation method and application
CN106334067A (en) * 2016-08-23 2017-01-18 广州洁康卫生用品有限公司 Gynecological gel containing silver-ion bactericide, preparation method and application thereof

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