CN101147769A - Method for preparing traditional Chinese medicine gel preparation for treating cervical erosion and vaginitis - Google Patents
Method for preparing traditional Chinese medicine gel preparation for treating cervical erosion and vaginitis Download PDFInfo
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- CN101147769A CN101147769A CNA2006100171937A CN200610017193A CN101147769A CN 101147769 A CN101147769 A CN 101147769A CN A2006100171937 A CNA2006100171937 A CN A2006100171937A CN 200610017193 A CN200610017193 A CN 200610017193A CN 101147769 A CN101147769 A CN 101147769A
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Abstract
The present invention relates to a Chinese medicine gel preparation for effectively curing cervical erosion and vaginitis. It is made up by using 6 Chinese medicinal materials of cutch, calcined alum, borneol, phellodendron bark, flavescent sophora root and puccoon through a certain preparation process. Besides, said invention also provides its concrete application method.
Description
Technical field
The invention belongs to the pharmaceutical technology field, be specifically related to a kind of preparation method for the treatment of cervical erosion, vaginitis Chinese medicine gel, international Patent classificating number: A61K 35/78, A61P15/02.
Background technology
The female friend has just determined to be subjected to easily extraneous antibacterial and viral infection from physiological structure, China has 80% women to suffer from gynaecopathia of different nature approximately, and wherein the married woman accounts for 90.5%, as chronic cervicitis, account for the married woman more than 50%, China has 1.1 hundred million women to suffer from this disease approximately.Virus and bacterial infection cause many gynaecopathias.As chronic cervicitis (cervical erosion), cervical cancer, vaginitis, leucorrhea abnormal, genital herpes, genital wart etc. under many circumstances, exist antibacterial and virus to infect simultaneously.
Vaginitis is the general name of the multiple vaginal mucosa inflammatory disease that causes of the different causes of disease.The normal physiological state, the histological anatomy of vagina and biochemical characteristics are enough to defend the invasion and attack of external microbe.If destroyed, then pathogen can be taken advantage of the occasion and be gone into, and borrows all factors, causes colpitis.
Mucosa delivery is meant that medicine closely contacts with the biological mucosa surface, enters the administering mode of blood circulation by epithelial cell.Mucosa delivery except have can avoid being subjected to effect, blood drug level steadily, the characteristics of transdermal administration such as long action time, application be convenient, also because there is not the such keratinization of skin in mucosa, and blood capillary is abundant under the mucosa, characteristics such as make mucosa delivery have that dosage is little, bioavailability is high and action time is fast.
The present invention treats cervical erosion, colpitic Chinese medicine gel is to be got by the XIAOMI SHUAN dosage changing form, and former suppository is with part pulverizing medicinal materials in the prescription, after the part medicinal material extract, filtrate is condensed into thick paste, the medical material fine powder is joined in the thick paste, and after the substrate that adding suits, molding promptly.Suppository has the fusion of chance body temperature and easily runs off, affects the treatment, and easy pollution clothes, the patient has shortcomings such as sense of discomfort.And the present invention has no foreign body sensation, nonirritant, characteristics that bioavailability is high.
Summary of the invention
The objective of the invention is to adopt the modern Chinese medicine production technology, provide a kind of rapid-action, bioavailability is high, the preparation method of treatment cervical erosion easy to use, stay-in-grade, vaginitis Chinese medicine gel.
The present invention is according to the prescription of 583 pages of XIAOMI SHUAN of 2005 editions " pharmacopeia " ministerial standards, and its prescription is as follows:
Stem and leaf of Radix Ginseng saponin 25g, Radix Arnebiae (Radix Lithospermi) 500g, Cortex Phellodendri 500g, Radix Sophorae Flavescentis 500g,
Dried Alumen 400g, Borneolum Syntheticum 200g, catechu 500g;
The present invention adopts in the modern Chinese medicine production technology, and above-mentioned raw materials medicine and the substrate that suits are prepared into gel;
Its preparation technology is as follows:
(1) catechu, dried Alumen are dissolved in water respectively, and amount of water is 5～30 times of medical material amount, filter, and filtrate decompression is concentrated into 60 ℃, and to record relative density be 1.05～1.25 clear paste;
(2) Borneolum Syntheticum porphyrize is crossed 80～120 mesh sieves, and is standby;
(3) Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi) decoct with water three times, 2 hours for the first time, add 3～10 times of water gagings; Second and third time each 1 hour, amount of water is followed successively by 4～8 times of water gagings, 4～8 times of water gagings, merge three times decocting liquid, being concentrated into 80 ℃, to record relative density be 1.00～1.50 clear paste, adds ethanol and make and contain the alcohol amount and reach 75%, left standstill 24 hours, get supernatant and reclaim ethanol, being concentrated into 80 ℃, to record relative density be 1.00～1.50 clear paste, adds tween 80 and stem and leaf of Radix Ginseng saponin, sodium benzoate, stir, standby;
(4) get recipe quantity substrate, the polar solvent that adds 5%-50% mixes, treat abundant swelling after, transfer PH5～8 with triethanolamine, add disodium EDTA 3～10g, stir, standby;
(5) get dried Alumen liquid, transfer PH5～8 with triethanolamine, join in (4) reserve liquid, the limit edged stirs, and slowly adds in (3) reserve liquid under be the even gel shape, stirring, and the limit edged is stirred to evenly;
(6) get in the polar solvent that the Borneolum Syntheticum fine powder joins 1%-10%, stir, add the catechu extracting solution again, continue to be stirred to uniform pasty state;
(7) (6) are joined in (5), stir, add water to ormal weight, continue to be stirred to evenly, packing promptly gets the present invention.
Substrate described in the present invention is one or more in carbomer, polyacrylamide, cross linked sodium polyacrylate, methylcellulose, sodium carboxymethyl cellulose, the hydroxypropyl emthylcellulose.
Used polar solvent is meant that weight concentration is the aqueous solution of 10～40% glycerol or 10～40% propylene glycol among the present invention.
Foundation of the present invention
1, prescription foundation
The present invention is according to the prescription of 583 pages of XIAOMI SHUAN of 2005 editions " pharmacopeia " ministerial standards.The present invention is made up of stem and leaf of Radix Ginseng saponin, Radix Arnebiae (Radix Lithospermi), Cortex Phellodendri, Radix Sophorae Flavescentis, dried Alumen, Borneolum Syntheticum, catechu seven flavor Chinese medicines, and Radix Arnebiae (Radix Lithospermi) has antiinflammatory, antibiotic in the prescription, the effect of heat-clearing and toxic substances removing; Radix Sophorae Flavescentis has heat clearing and damp drying, parasite killing diuretic actions; Cortex Phellodendri has heat clearing and damp drying, the pathogenic fire purging heat extraction, and the effect of skin ulcer is treated in detoxifcation, catechu external astringent therapy, holds back skin ulcer, hemostasis, and Borneolum Syntheticum has the effect of clearing away heat to alleviate pain; Dried Alumen has the effect of detoxifcation parasite killing, dampness removing to stop itchin; The stem and leaf of Radix Ginseng saponin, the effect of have QI invigorating, lung benefiting, drive away summer heat, promoting the production of body fluid.
2, adjuvant foundation
The screening of prescription adjuvant is according to " pharmaceutical necessities complete works " nineteen ninety-five front page, and adjuvant of the present invention is carbomer, glycerol, tween 80, disodium EDTA (EDTA-2Na);
Usage of the present invention and consumption: be applied to clean affected part, 2～4 times on the one; Or get ampoule (5g), send into the vagina depths with medicine feeding machine, 1 time on the one.
The present invention reaches the requirement of state-promulgated pharmacopoeia after tested.
Use the preparation of the present invention's preparation, in vaginal canal, be uniformly dispersed, spreading area is wide, medicine can effectively infiltrate mucosal fold, improved bioavailability, guaranteed curative effect, and made things convenient for the patient to take, pollution clothes not has no foreign body sensation, nonirritant, good effect that bioavailability is high.
The specific embodiment
Embodiment 1:
Stem and leaf of Radix Ginseng saponin 25g, Radix Arnebiae (Radix Lithospermi) 500g, Cortex Phellodendri 500g, Radix Sophorae Flavescentis 500g, dried Alumen 400g, Borneolum Syntheticum 200g, catechu 500g, tween 80 350g, glycerol 300g, sodium benzoate 3g, disodium EDTA 5g;
Preparation technology:
(1) catechu, dried Alumen are dissolved in water respectively, and amount of water is 20 times of medical material amount, filter, and filtrate decompression is concentrated into 60 ℃, and to record relative density be 1.05～1.10 clear paste;
(2) Borneolum Syntheticum porphyrize is crossed 100 mesh sieves, and is standby;
(3) Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi) decoct with water three times, 2 hours for the first time, add 6 times of water gagings; Second and third time each 1 hour, amount of water is followed successively by 5 times of water gagings, 5 times of water gagings, merge three times decocting liquid, being concentrated into 80 ℃, to record relative density be 1.10～1.15 clear paste, adds ethanol and make and contain the alcohol amount and reach 75%, left standstill 24 hours, get supernatant and reclaim ethanol, being concentrated into 80 ℃, to record relative density be 1.10～1.15 clear paste, adds tween 80 and stem and leaf of Radix Ginseng saponin, sodium benzoate, stir, standby;
(4) get the recipe quantity carbomer, add 20% aqueous solution of propylene glycol and mix, treat abundant swelling after, transfer PH5 with triethanolamine, add disodium EDTA, stir, standby;
(5) get dried Alumen liquid, transfer PH5 with triethanolamine, join in (4) reserve liquid, the limit edged stirs, and slowly adds in (3) reserve liquid under be the even gel shape, stirring, and the limit edged is stirred to evenly.
(6) get the Borneolum Syntheticum fine powder and join in 10% the aqueous solution of propylene glycol, stir, add the catechu extracting solution again, continue to be stirred to uniform pasty state;
(7) (6) are joined in (5), stir, add water to ormal weight, continue to be stirred to even gel, packing promptly gets the present invention.
Embodiment 2:
Stem and leaf of Radix Ginseng saponin 25g, Radix Arnebiae (Radix Lithospermi) 500g, Cortex Phellodendri 500g, Radix Sophorae Flavescentis 500g, dried Alumen 400g, Borneolum Syntheticum 200g, catechu 500g, tween 80 350g, glycerol 300g, sodium benzoate 3g, disodium EDTA 6g;
Preparation technology:
(1) catechu, dried Alumen are dissolved in water respectively, and amount of water is 25 times of medical material amount, filter, and filtrate decompression is concentrated into 60 ℃, and to record relative density be 1.10～1.15 clear paste;
(2) Borneolum Syntheticum porphyrize is crossed 80 mesh sieves, and is standby;
(3) Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi) decoct with water three times, 2 hours for the first time, add 7 times of water gagings; Second and third time each 1 hour, amount of water is followed successively by 6 times of water gagings, 5 times of water gagings, merge three times decocting liquid, being concentrated into 80 ℃, to record relative density be 1.00～1.05 clear paste, adds ethanol and make and contain the alcohol amount and reach 75%, left standstill 24 hours, get supernatant and reclaim ethanol, being concentrated into 80 ℃, to record relative density be 1.00～1.05 clear paste, adds tween 80 and stem and leaf of Radix Ginseng saponin, sodium benzoate, stir, standby;
(4) get the recipe quantity polyacrylamide, add 30% aqueous solution of propylene glycol and mix, treat abundant swelling after, transfer PH6 with triethanolamine, add disodium EDTA, stir, standby;
(5) get dried Alumen liquid, transfer PH6 with triethanolamine, join in (4) reserve liquid, the limit edged stirs, and slowly adds in (3) reserve liquid under be the even gel shape, stirring, and the limit edged is stirred to evenly;
(6) get the Borneolum Syntheticum fine powder and join in 8% the aqueous solution of propylene glycol, stir, add the catechu extracting solution again, continue to be stirred to uniform pasty state;
(7) (6) are joined in (5), stir, add water to ormal weight, continue to be stirred to even gel, packing promptly gets the present invention.
Embodiment 3:
Stem and leaf of Radix Ginseng saponin 25g, Radix Arnebiae (Radix Lithospermi) 500g, Cortex Phellodendri 500g, Radix Sophorae Flavescentis 500g, dried Alumen 400g, Borneolum Syntheticum 200g, catechu 500g, tween 80 350g, glycerol 320g, sodium benzoate 3g, disodium EDTA 8g;
Preparation technology:
(1) catechu, dried Alumen are dissolved in water respectively, and amount of water is 15 times of medical material amount, filter, and filtrate decompression is concentrated into 60 ℃, and to record relative density be 1.15～1.20 clear paste;
(2) Borneolum Syntheticum porphyrize is crossed 120 mesh sieves, and is standby;
(3) Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi) decoct with water three times, 2 hours for the first time, add 810 times of water gagings; Second and third time each 1 hour, amount of water is followed successively by 6 times of water gagings, 4 times of water gagings, merge three times decocting liquid, being concentrated into 80 ℃, to record relative density be 1.15～1.20 clear paste, adds ethanol and make and contain the alcohol amount and reach 75%, left standstill 24 hours, get supernatant and reclaim ethanol, being concentrated into 80 ℃, to record relative density be 1.15～1.20 clear paste, adds tween 80 and stem and leaf of Radix Ginseng saponin, sodium benzoate, stir, standby;
(4) get the recipe quantity cross linked sodium polyacrylate, add 40% glycerine water solution and mix, treat abundant swelling after, transfer PH7 with triethanolamine, add disodium EDTA, stir, standby;
(5) get dried Alumen liquid, transfer PH7 with triethanolamine, join in (4) reserve liquid, the limit edged stirs, and slowly adds in (3) reserve liquid under be the even gel shape, stirring, and the limit edged is stirred to evenly;
(6) get the Borneolum Syntheticum fine powder and join in 5% the glycerine water solution, stir, add the catechu extracting solution again, continue to be stirred to uniform pasty state;
(7) (6) are joined in (5), stir, add water to ormal weight, continue to be stirred to even gel, packing promptly gets the present invention.
Embodiment 4:
Stem and leaf of Radix Ginseng saponin 25g, Radix Arnebiae (Radix Lithospermi) 500g, Cortex Phellodendri 500g, Radix Sophorae Flavescentis 500g, dried Alumen 400g, Borneolum Syntheticum 200g, catechu 500g, tween 80 300g, glycerol 220g, sodium benzoate 3g, disodium EDTA 10g;
Preparation technology:
(1) catechu, dried Alumen are dissolved in water respectively, and amount of water is 30 times of medical material amount, filter, and filtrate decompression is concentrated into 60 ℃, and to record relative density be 1.10～1.15 clear paste;
(2) Borneolum Syntheticum porphyrize is crossed 100 mesh sieves, and is standby;
(3) Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi) decoct with water three times, 2 hours for the first time, add 10 times of water gagings; Second and third time each 1 hour, amount of water is followed successively by 8 times of water gagings, 8 times of water gagings, merge three times decocting liquid, being concentrated into 80 ℃, to record relative density be 1.20～1.25 clear paste, adds ethanol and make and contain the alcohol amount and reach 75%, left standstill 24 hours, get supernatant and reclaim ethanol, being concentrated into 80 ℃, to record relative density be 1.20～1.25 clear paste, adds tween 80 and stem and leaf of Radix Ginseng saponin, sodium benzoate, stir, standby;
(4) get the recipe quantity sodium carboxymethyl cellulose, add 50% glycerine water solution and mix, treat abundant swelling after, transfer PH8 with triethanolamine, add disodium EDTA, stir, standby;
(5) get dried Alumen liquid, transfer PH8 with triethanolamine, join in (4) reserve liquid, the limit edged stirs, and slowly adds in (3) reserve liquid under be the even gel shape, stirring, and the limit edged is stirred to evenly;
(6) get the Borneolum Syntheticum fine powder and join in 3% the glycerine water solution, stir, add the catechu extracting solution again, continue to be stirred to uniform pasty state;
(7) (6) are joined in (5), stir, add water to ormal weight, continue to be stirred to even gel, packing promptly gets the present invention.
Claims (4)
1. preparation method for the treatment of cervical erosion, vaginitis Chinese medicine gel may further comprise the steps:
(1) catechu, dried Alumen are dissolved in water respectively, and amount of water is 5～30 times of medical material amount, filter, and filtrate decompression is concentrated into 60 ℃, and to record relative density be 1.05～1.25 clear paste;
(2) Borneolum Syntheticum porphyrize is crossed 80～120 mesh sieves, and is standby;
(3) Cortex Phellodendri, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi) decoct with water three times, 2 hours for the first time, add 3～10 times of water gagings; Second and third time each 1 hour, amount of water is followed successively by 4～8 times of water gagings, 4～8 times of water gagings, merge three times decocting liquid, being concentrated into 80 ℃, to record relative density be 1.00～1.50 clear paste, adds ethanol and make and contain the alcohol amount and reach 75%, left standstill 24 hours, get supernatant and reclaim ethanol, being concentrated into 80 ℃, to record relative density be 1.00～1.50 clear paste, adds tween 80 and stem and leaf of Radix Ginseng saponin, sodium benzoate, stir, standby;
(4) get recipe quantity substrate, the polar solvent that adds 5%-50% mixes, treat abundant swelling after, transfer PH5～8 with triethanolamine, add disodium EDTA 3～10g, stir, standby;
(5) get dried Alumen liquid, transfer PH5～8 with triethanolamine, join in (4) reserve liquid, the limit edged stirs, and slowly adds in (3) reserve liquid under be the even gel shape, stirring, and the limit edged is stirred to evenly.
(6) get in the polar solvent that the Borneolum Syntheticum fine powder joins 1%-10%, stir, add the catechu extracting solution again, continue to be stirred to uniform pasty state;
(7) (6) are joined in (5), stir, add water to ormal weight, continue to be stirred to evenly to gel, packing promptly gets the present invention.
2. preparation method according to claim 1 is characterized in that: the Borneolum Syntheticum grinding particle size among the present invention is 120 orders.
3. preparation method according to claim 1 is characterized in that: described substrate is one or more in carbomer, polyacrylamide, cross linked sodium polyacrylate, methylcellulose, sodium carboxymethyl cellulose, the hydroxypropyl emthylcellulose.
4. preparation method according to claim 1 is characterized in that: used polar solvent is meant that weight concentration is the aqueous solution of 10～40% glycerol or 10～40% propylene glycol among the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100171937A CN101147769A (en) | 2006-09-20 | 2006-09-20 | Method for preparing traditional Chinese medicine gel preparation for treating cervical erosion and vaginitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100171937A CN101147769A (en) | 2006-09-20 | 2006-09-20 | Method for preparing traditional Chinese medicine gel preparation for treating cervical erosion and vaginitis |
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| CN101147769A true CN101147769A (en) | 2008-03-26 |
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| CNA2006100171937A Pending CN101147769A (en) | 2006-09-20 | 2006-09-20 | Method for preparing traditional Chinese medicine gel preparation for treating cervical erosion and vaginitis |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102335394A (en) * | 2011-10-11 | 2012-02-01 | 陕西东泰制药有限公司 | Chinese medicinal composition for treating cervical erosion and preparation method thereof |
| CN102727705A (en) * | 2012-07-20 | 2012-10-17 | 杨献华 | Traditional Chinese medicine composition for preventing or treating cervical erosion |
| CN102872256A (en) * | 2012-09-13 | 2013-01-16 | 顾洪 | Treatment type vagina gel and preparation method thereof |
| CN104055986A (en) * | 2014-06-19 | 2014-09-24 | 张金玉 | Traditional Chinese medicine composition for treating cervical erosion |
| CN110772571A (en) * | 2019-12-18 | 2020-02-11 | 河南中医药大学 | Yellow ginseng essential oil gel for treating cervical erosion |
| CN112156138A (en) * | 2020-08-06 | 2021-01-01 | 朱平 | Gynecological gel |
-
2006
- 2006-09-20 CN CNA2006100171937A patent/CN101147769A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102335394A (en) * | 2011-10-11 | 2012-02-01 | 陕西东泰制药有限公司 | Chinese medicinal composition for treating cervical erosion and preparation method thereof |
| CN102727705A (en) * | 2012-07-20 | 2012-10-17 | 杨献华 | Traditional Chinese medicine composition for preventing or treating cervical erosion |
| CN102872256A (en) * | 2012-09-13 | 2013-01-16 | 顾洪 | Treatment type vagina gel and preparation method thereof |
| CN104055986A (en) * | 2014-06-19 | 2014-09-24 | 张金玉 | Traditional Chinese medicine composition for treating cervical erosion |
| CN110772571A (en) * | 2019-12-18 | 2020-02-11 | 河南中医药大学 | Yellow ginseng essential oil gel for treating cervical erosion |
| CN112156138A (en) * | 2020-08-06 | 2021-01-01 | 朱平 | Gynecological gel |
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Open date: 20080326 |