CN103386010B

CN103386010B - Medicine used for treating sore and ulcer disease and preparation method thereof

Info

Publication number: CN103386010B
Application number: CN201310309614.3A
Authority: CN
Inventors: 肖振锋
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-07-23
Filing date: 2013-07-23
Publication date: 2015-07-15
Anticipated expiration: 2033-07-23
Also published as: CN103386010A

Abstract

The invention discloses a medicine used for treating a sore and ulcer disease and a preparation method thereof. The medicine is prepared mainly from Chinese angelica, pericarpium citri reticulatae, Chinese violet, honeysuckle flower, winter jasmine, and fritillaria cirrhosa according to a certain weight ratio. The medicine has functions of clearing away heat and draining dampness, clearing away toxic materials, removing swelling, promoting blood circulation and relieving pain. The medicine has rapid effectiveness, good curative effects and high cure rate when being used for treating the sore and ulcer disease.

Description

A kind of medicine for the treatment of skin infection and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of skin infection and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Skin infection is the common frequently-occurring disease of surgical clinical, and skin infection comprises all abscesss and ulcer, and as carbuncle, furuncle, furuncle and phyma, the tuberculosis of bone and joint, multiple abscess, scrofula is gone through.Be apt to occur in summer and autumn, the four seasons all can fall ill.This type of disease is the clinical commonly encountered diseases frequently-occurring disease of surgery of Chinese medicine, and have morbidity rapidly, the features such as the part state of an illness is heavier, can cause furunche complicated with septicemia at face, easily causes muscle and tendon injury to damage the serious consequence of bone at hands, foot.Wound just defines skin infection after there is infection.At present, due to western medicine skin infection poor effect, and easily recur, and have more side effect, therefore, there is very large demand to the Chinese medicine of effectively treating skin infection in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment skin infection, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating skin infection.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Herba Violae, Flos Lonicerae, Flos Jasmini Nudiflori, Bulbus Fritillariae Cirrhosae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Olibanum, Myrrha, Squama Manis, Spina Gleditsiae medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of skin infection.Wherein select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Herba Violae is selected to be that cold, enter the heart, Liver Channel, have clearing away heat-damp and promoting diuresis, the function of removing toxic substances and promoting subsidence of swelling, controls furuncle, carbuncle, scrofula, jaundice, dysentery because its nature and flavor are bitter, diarrhoea, conjunctival congestion, sore throat, venom.Flos Lonicerae is selected to be because its nature and flavor are sweet, cold, enter lung, stomach warp, have heat clearing away, the function of removing toxic substances, control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Flos Jasmini Nudiflori is selected to be that flat, have heat clearing away, the function of drawing out pus by applying a plaster to the affected part, cures mainly toxic swelling, malignant boil because its nature and flavor are pained.Bulbus Fritillariae Cirrhosae is selected to be because its property bitter but sweet flavor, cool, enter lung meridian, have lung moistening eliminating stagnation, the function that antitussive reduces phlegm, control cough due to consumptive disease, spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, goiter, scrofula, sore throat, acute mastitis.Select Radix Saposhnikoviae to be because its property acrid-sweet flavor, temperature, enters bladder, lung, spleen channel, delivers, dispel the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, anemofrigid-damp arthralgia, and joint is ached, and extremity contraction is anxious, tetanus.Select the Radix Angelicae Dahuricae to be that temperature, enters lung, spleen, stomach warp, dispel the wind, dampness because its nature and flavor are pungent, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, and cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Olibanum to be that temperature, enters the heart, liver, spleen channel, have regulating qi and activating blood, analgesic therapy because its nature and flavor are worked hard, chase after the function of poison, control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Myrrha is selected to be that flat, enter Liver Channel, have loose blood blood stasis removing, the function of subduing swelling and relieving pain, controls and fall damage, incised wound, muscles and bones, trusted subordinate all Tong ， mass in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye because its nature and flavor are bitter.Select Squama Manis to be because its nature and flavor are salty, cool, enter liver, stomach warp, have the routed carbuncle of detumescence, search wind active, the function of stimulating milk secretion of stimulating the menstrual flow, control carbuncle skin ulcer and swell, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external is stopped blooding.Select Spina Gleditsiae to be that temperature, searches wind, draw out pus by applying a plaster to the affected part because its nature and flavor are pungent, detumescence, the function of evacuation of pus, controls carbuncle, sore, leprosy, tinea skin ulcer, placenta retention.

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Radix Angelicae Sinensis 10-20 grams of Pericarpium Citri Reticulataes 10-20 grams of Herba Violaes 10-20 grams

Flos Lonicerae 10-20 grams of Flos Jasmini Nudifloris 10-20 grams of Bulbus Fritillariae Cirrhosaes 8-12 grams

Radix Saposhnikoviae 8-12 grams of Radixs Angelicae Dahuricae 8-12 grams of Olibanums 8-12 grams

Myrrha 8-12 grams of Squama Maniss 8-12 grams of Spina Gleditsiaes 8-12 grams

Preferable amount is

Radix Angelicae Sinensis 15 grams of Pericarpium Citri Reticulataes 15 grams of Herba Violaes 15 grams

Flos Lonicerae 15 grams of Flos Jasmini Nudifloris 15 grams of Bulbus Fritillariae Cirrhosaes 10 grams

Radix Saposhnikoviae 10 grams of Radixs Angelicae Dahuricae 10 grams of Olibanums 10 grams

Myrrha 10 grams of Squama Maniss 10 grams of Spina Gleditsiaes 10 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;

2, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;

3, Herba Violae: pick clean impurity, wash earth with water, cutting, dry;

4, Flos Lonicerae: sieve removes silt, picks clean impurity, dries;

5, Flos Jasmini Nudiflori: pick clean impurity, sieve removes silt, dries in the shade;

6, Bulbus Fritillariae Cirrhosae: pick decontamination, is soaked in water, and pulls out, and moistening peels off the heart, dries;

7, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

8, the Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;

9, Olibanum: pick the sub-impurity of shakeout;

10, Myrrha: pick decontamination, breaks into fragment;

11, Squama Manis: get the Squama Manis sheet picking clean, separately size, separately put sand in pot and fry to easily, add Squama Manis sheet, frying to heaving in time golden yellow, taking out, and sieve shakeout, cools;

12, Spina Gleditsiae: pick decontamination, is soaked in water, and runs through rear section, dries.

Two, prepare

1, the Radix Angelicae Sinensis of described weight, Pericarpium Citri Reticulatae, Herba Violae, Flos Lonicerae, Flos Jasmini Nudiflori, Bulbus Fritillariae Cirrhosae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Olibanum, Myrrha, Squama Manis, Spina Gleditsiae medicine are decocted with water, add water 5 times amount for the first time, soak after 60 minutes, intense fire decocts boiling 25 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor.

2, add water the medicinal residues of filtration 3 times amount, first boils with high heat, then use slow fire boiling 15 minutes, filters to obtain second time decoction liquor.

3, by twice decoction liquor mixing and stirring, be divided into 3 doses and take.

Medicine of the present invention has clearing away heat-damp and promoting diuresis, and removing toxic substances and promoting subsidence of swelling is invigorated blood circulation, effect of analgesic therapy, and treatment skin infection instant effect, short treating period, do not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 40, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 20, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient 260 example for medical treatment.

2, diagnostic criteria

All skin infection illness all form because gas gathers blood clotting, and originally local skin plays a red bumps or scleroma, and root foot is very shallow, and limit has red and swollen heat pain, sometimes can have heating, xerostomia, constipation etc.Stone furuncle, hidradenitis suppurativa, summer boil, furunculosis, folliculitis abscedens et suffodiens etc. can be divided into.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 5 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: transference cure, skin infection is fully recovered, and body constitution recovers normal, observes half a year without recidivist;

Take a turn for the better: symptom is clearly better, and symptom fades away;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy skin infection patient 260 example of the present invention, effective 245 examples of result, obvious effective rate is 94.23%, and take a turn for the better 10 examples, and improvement rate is 3.85%, and invalid 5 examples, total effective rate is 98.08%.

Claims

1. treat a medicine for skin infection, it is characterized in that: it is made up of the crude drug in following weight range:

Myrrha 8-12 grams of Squama Maniss 8-12 grams of Spina Gleditsiaes 8-12 grams.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Myrrha 10 grams of Squama Maniss 10 grams of Spina Gleditsiaes 10 grams.

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;

(2) Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;

(3) Herba Violae: pick clean impurity, wash earth with water, cutting, dry;

(4) Flos Lonicerae: sieve removes silt, picks clean impurity, dries;

(5) Flos Jasmini Nudiflori: pick clean impurity, sieve removes silt, dries in the shade;

(6) Bulbus Fritillariae Cirrhosae: pick decontamination, is soaked in water, and pulls out, and moistening peels off the heart, dries;

(7) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

(8) Radix Angelicae Dahuricae: pick clean impurity, wash, soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying;

(9) Olibanum: pick the sub-impurity of shakeout;

(10) Myrrha: pick decontamination, breaks into fragment;

(11) Squama Manis: get the Squama Manis sheet picking clean, separately size, separately put sand in pot and fry to easily, add Squama Manis sheet, frying to heaving in time golden yellow, taking out, and sieve shakeout, cools;

(12) Spina Gleditsiae: pick decontamination, is soaked in water, and runs through rear section, dries;

(2) prepare

(1) Radix Angelicae Sinensis of described weight, Pericarpium Citri Reticulatae, Herba Violae, Flos Lonicerae, Flos Jasmini Nudiflori, Bulbus Fritillariae Cirrhosae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Olibanum, Myrrha, Squama Manis, Spina Gleditsiae medicine are decocted with water, add water 5 times amount for the first time, soak after 60 minutes, intense fire decocts boiling 25 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor;

(2) add water the medicinal residues of filtration 3 times amount, first boils with high heat, then use slow fire boiling 15 minutes, filters to obtain second time decoction liquor;

(3) by twice decoction liquor mixing and stirring, be divided into 3 doses and take.