CN103405597B - One treats arteriosclerotic medicine and preparation method thereof - Google Patents

Abstract

The invention discloses one and treat arteriosclerotic medicine and preparation method thereof, it is mainly prepared from according to a certain weight ratio by medicines such as Placenta Hominis, Semen Persicae, Arillus Longan, Radix Salviae Miltiorrhizae, Rhizoma Acori Graminei, Poria, Radix Polygalae and Radix Rehmanniae Preparata, medicine of the present invention has blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, to regulate the flow of vital energy the function of drying, be used for the treatment of arteriosclerosis, do not recur after recovery from illness.

Description

One treats arteriosclerotic medicine and preparation method thereof

Technical field

The present invention relates to one and treat arteriosclerotic medicine and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Arteriosclerosis is a kind of non-inflammation pathological changes of tremulous pulse, ductus arteriosus wall can be made to thicken, hardening, follows the string, tube chamber is narrow and small.Arteriosclerosis is the angiopathy increasing along with people's age and occur, its rule normally occurs at adolescence, increases the weight of period to person in middle and old age, falls ill.Male is many compared with women, and primary disease increases gradually in China in recent years, becomes one of old people's main causes of death.At present, western medicine arteriosclerosis poor effect, and have more side effect, and therefore, the demand that people are very large to effectively treatment arteriosclerotic Chinese medicine existence.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the effectively arteriosclerotic medicine for the treatment of, thus completes the present invention.

Object of the present invention is just to provide one can effectively treat arteriosclerotic composition of medicine.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Placenta Hominis, Semen Persicae, Arillus Longan, Radix Salviae Miltiorrhizae, Rhizoma Acori Graminei, Poria, Radix Polygalae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Achyranthis Bidentatae, Stigma Croci, Rhizoma Alismatis medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus can effectively treat arteriosclerotic recurrence.Wherein select Placenta Hominis to be because its property sweet-salty, temperature, enters lung, liver, kidney channel, has QI invigorating, nourish blood, and the function of benefit essence, controls deficient, weakness and emaciation, consumptive fever hectic fever due to YIN-deficiency, cough with asthma, spitting of blood, night sweat, seminal emission, sexual impotence, and women's vim and vigour are not enough, infertile or newborn few.Semen Persicae is selected to be because its property bitter but sweet flavor, flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select Arillus Longan to be because its nature and flavor are sweet, temperature, enter the heart, spleen channel, have heart-spleen boosting, fill blood, the function of calming the nerves, controls virtual work thin and weak, insomnia, forgetful, palpitation with fear, severe palpitation.Radix Salviae Miltiorrhizae is selected to be that tepor, enters the heart, Liver Channel, have blood circulation and promoting silt, calming heart and tranquilizing mind, evacuation of pus, and the function of pain relieving, controls angina cordis, menoxenia, dysmenorrhea, and to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia because its nature and flavor are bitter, palpitation with fear sleeplessness, malignant boil toxic swelling.Rhizoma Acori Graminei is selected to be that tepor, enters the heart, liver, spleen channel, have and have one's ideas straightened out, eliminating phlegm, regulate the flow of vital energy, invigorate blood circulation because its nature and flavor are worked hard, loose wind, the function of drying, Zhi epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Select Radix Polygalae to be because its nature and flavor toil, temperature, enter the heart, kidney channel, have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the function of resolving depression, controls palpitation with fear, forgetful, nocturnal emission, insomnia, cough ant phlegm, and carbuncle skin ulcer swells.Select Radix Rehmanniae Preparata to be that tepor, enters liver, kidney channel, have YIN nourishing, and the function of enriching blood controls deficiency of YIN insufficiency of blood, waist knee flaccidity, chronic cough hectic fever due to YIN-deficiency because its nature and flavor are sweet, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deaf, blurred vision.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid, flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and the function of subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury, ripe invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Select Stigma Croci to be that flat, enter the heart, Liver Channel, have blood circulation promoting and blood stasis dispelling, the function of dispersing stagnation and relieving accumulation of pathogens, control troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed because its nature and flavor are sweet, spit blood, typhoid fever is gone mad, and frightened fear in a trance, women's amenorrhea, postnatal blood stasis is suffered from abdominal pain, tumbling and swelling.Select Rhizoma Alismatis to be that cold, enter urinary bladder channel, have diuretic, eliminating dampness by diuresis, the function expelled the heat-evil, controls dysuria because its nature and flavor are sweet, edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Placenta Hominis 8-15 gram of Semen Persicae 45-55 gram of Arillus Longan 8-15 gram

Radix Salviae Miltiorrhizae 10-20 gram of Rhizoma Acori Graminei 10-20 gram of Poria 10-20 gram

Radix Polygalae 10-20 gram of Radix Rehmanniae Preparata 8-15 gram of Radix Angelicae Sinensis 8-15 gram

Radix Paeoniae Alba 10-15 gram of Radix Achyranthis Bidentatae 8-15 gram of Stigma Croci 8-15 gram

Rhizoma Alismatis 8-15 gram

Preferable amount is

Placenta Hominis 10 grams of Semen Persicaes 50 grams of Arillus Longans 10 grams

15 grams, Radix Salviae Miltiorrhizae 15 grams of Rhizoma Acori Graminei 15 grams of Poria

Radix Polygalae 15 grams of Radix Rehmanniae Preparata 10 grams of Radix Angelicae Sinensis 10 grams

The Radix Paeoniae Alba 12 grams of Radix Achyranthis Bidentataes 10 grams of Stigma Crocis 10 grams

Rhizoma Alismatis 10 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Placenta Hominis: with fresh Placenta Hominis, anyhow cut open blood vessel, washes drift totally repeatedly with water;

2, Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

3, Arillus Longan: get crude drug, removing impurity;

4, Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;

5, Rhizoma Acori Graminei: pick decontamination, cleans, slightly soaks, run through, and section, dries;

6, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;

7, Radix Polygalae: pick decontamination, cutting, sieve dedust bits;

8, Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;

9, Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;

10, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;

11, Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

12, Stigma Croci: pick decontamination, and remove yellow feeler;

13, Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries.

Two, prepare

1, by the Placenta Hominis of described weight, Semen Persicae, Arillus Longan, Radix Salviae Miltiorrhizae, Rhizoma Acori Graminei, Poria, Radix Polygalae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Achyranthis Bidentatae, Stigma Croci, Rhizoma Alismatis drug decocting secondary, add water 6 times amount for the first time, soak after 80 minutes, intense fire decocts boiling 25 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor.

2, add water the medicinal residues of filtration 4 times amount, first boils with high heat, then use slow fire boiling 20 minutes, filters to obtain second time decoction liquor.

3, merge twice decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, medicinal liquid is divided into 6 doses and takes.

Medicine of the present invention has blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, resolving depression of regulating the flow of vital energy, loose wind, and the function of drying, is used for the treatment of arteriosclerosis, short treating period, instant effect, non-relapse after healing, has no side effect.

Detailed description of the invention

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The arteriosclerotic clinical observation material of [test example 2] Drug therapy of the present invention

1, physical data

Accept out-patient's totally 100 examples for medical treatment, wherein patients with mild 70 example, middle severe patient 30 example.

2, diagnostic criteria

Clinical manifestation: atherosclerotic performance depends mainly on the degree of ischemia of vascular lesion and afflicted organ, for early stage arteriosclerosis patient, Most patients nearly all without any clinical symptoms, development of hiding under being all in hidden evil thoughts state.For in the arteriosclerosis patient of interim severe, Most patients has the clinical symptoms such as cardiopalmus more or less, nervous, chest pain, uncomfortable in chest, headache, dizziness, the cool fiber crops of extremity, listless and aching, limping, vision reduction, hypomnesis, insomnia, dreaminess.

3, Therapeutic Method

Select described medicament, take to patient, patients with mild is each serving with 1 dose, and every day early, evening respectively takes 1 time, within 30 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.Middle severe patient per takes 1 dose, and every day is early, middle and late respectively takes 1 time, within 30 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: arteriosclerosis symptom disappears, body constitution recovers normal, observes half a year without recidivist;

Take a turn for the better: arteriosclerosis symptom is clearly better, and body constitution is progressively recovered;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy arteriosclerotic 100 example of the present invention, wherein patients with mild 70 example, effective 60 examples of result, obvious effective rate is 85.71%, and take a turn for the better 8 examples, and improvement rate is 11.43%, and invalid 2 examples, total effective rate is 97.14%.Middle severe patient 30 example, effective 26 examples of result, obvious effective rate is 86.67%, and take a turn for the better 3 examples, and improvement rate is 10%, and invalid 1 example, total effective rate is 96.67%.

Claims (3)

1. treat an arteriosclerotic medicine, it is characterized in that: it is made up of the crude drug in following weight range:

Placenta Hominis 8-15 gram of Semen Persicae 45-55 gram of Arillus Longan 8-15 gram

Radix Salviae Miltiorrhizae 10-20 gram of Rhizoma Acori Graminei 10-20 gram of Poria 10-20 gram

Radix Polygalae 10-20 gram of Radix Rehmanniae Preparata 8-15 gram of Radix Angelicae Sinensis 8-15 gram

Radix Paeoniae Alba 10-15 gram of Radix Achyranthis Bidentatae 8-15 gram of Stigma Croci 8-15 gram

Rhizoma Alismatis 8-15 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Placenta Hominis 10 grams of Semen Persicaes 50 grams of Arillus Longans 10 grams

15 grams, Radix Salviae Miltiorrhizae 15 grams of Rhizoma Acori Graminei 15 grams of Poria

Radix Polygalae 15 grams of Radix Rehmanniae Preparata 10 grams of Radix Angelicae Sinensis 10 grams

The Radix Paeoniae Alba 12 grams of Radix Achyranthis Bidentataes 10 grams of Stigma Crocis 10 grams

Rhizoma Alismatis 10 grams.

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Placenta Hominis: with fresh Placenta Hominis, anyhow cut open blood vessel, washes drift totally repeatedly with water;

(2) Semen Persicae: removing duricrust impurity, puts in boiling water pot and boils to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;

(3) Arillus Longan: get crude drug, removing impurity;

(4) Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;

(5) Rhizoma Acori Graminei: pick decontamination, cleans, slightly soaks, run through, and section, dries;

(6) Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;

(7) Radix Polygalae: pick decontamination, cutting, sieve dedust bits;

(8) Radix Rehmanniae Preparata: get crude drug, steams to surperficial corvinus, takes out, when shining dry to eighty per cant, and section, dry;

(9) Radix Angelicae Sinensis: pick decontamination, cleans, moistening, and slightly dry in the air when being suitable for inside and outside humidity, section is dried;

(10) Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;

(11) Radix Achyranthis Bidentatae: pick decontamination, cleans, softens, go reed, cutting, dry;

(12) Stigma Croci: pick decontamination, and remove yellow feeler;

(13) Rhizoma Alismatis: pick decontamination, size stepping, be soaked in water to eighty per cant thoroughly, pull out, shine cool, moistening is even to inside and outside humidity, and section, dries;

(2) prepare

(1) by the Placenta Hominis of described weight, Semen Persicae, Arillus Longan, Radix Salviae Miltiorrhizae, Rhizoma Acori Graminei, Poria, Radix Polygalae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Achyranthis Bidentatae, Stigma Croci, Rhizoma Alismatis drug decocting secondary, add water 6 times amount for the first time, soak after 80 minutes, intense fire decocts boiling 25 minutes, use slow fire boiling again 20 minutes, filter first time decoction liquor;

(2) add water the medicinal residues of filtration 4 times amount, first boils with high heat, then use slow fire boiling 20 minutes, filters to obtain second time decoction liquor;

(3) merge twice decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, medicinal liquid is divided into 6 doses and takes.