CN104056120A - Drug for treatment of deep phlebitis and preparation method thereof - Google Patents
Drug for treatment of deep phlebitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a drug for treatment of deep phlebitis and a preparation method thereof. The drug is prepared mainly from Sevenlobed Yam Rhizome, coix seed, phellodendron, red poria cocos, cortex moutan, rhizoma alismatis, talc and Ricepaperplant Pith according to certain weight ratio. The drug provided by the invention has the functions of clearing heat and promoting dieresis, removing toxin and disperse swelling, activating blood circulation and removing stasis, and can reach the effects of quick effect, good effect and no recurrence when used for treatment of deep phlebitis.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of deep phlebitis and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Deep phlebitis refers to the acute aseptic inflammation of vein blood vessel, and a few patients can have heating, total white blood cells to increase etc., and patient usually states pain and swelling.The cause of disease that causes venous thrombosis is a lot, as wound, operation, gestation, childbirth, heart disease, malignant tumor, oral contraceptive and stand for a long time, squat down, sitting, lying on bed for a long time etc., more commonly after surgical operation, cause primary disease.At present, because Western medicine cannot effectively be treated phlebitis, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effective treatment deep phlebitis.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the phlebitic medicine of effective treatment, thereby has completed the present invention.
Object of the present invention is just to provide a kind of composition of medicine that can effectively treat deep phlebitis.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Rhizoma Dioscoreae Septemlobae, Semen Coicis, Cortex Phellodendri, Poria, Cortex Moutan, Rhizoma Alismatis, Talcum, Medulla Tetrapanacis, Poria, Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Plantaginis, Herba Violae medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat deep phlebitis.Wherein select Rhizoma Dioscoreae Septemlobae to be because its nature and flavor are bitter, flat, enter liver, stomach, urinary bladder channel, dispel the wind, the function of dampness removing, dispelling the wind and dampness pathogens insensitive impediment, lumbocrural pain, dysuria, stranguria with turbid discharge, seminal emission, damp and hot sore.Select Semen Coicis to be because its property slightly sweet flavor is cool, enter spleen, lung, kidney channel, have spleen invigorating, tonifying the lung, heat clearing away, the function of dampness removing, controls and has loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.Select Cortex Phellodendri to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, there is nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, urinary bladder channel, have row water, the function of dampness removing heat, controls dysuria, stranguria with turbid discharge, dysentery.Select Cortex Moutan to be because its nature and flavor are arduous, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, sends out speckle , Jing Epilepsy, and tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea , mass in the abdomen, carbuncle and ulcer, flutters damage.Select Rhizoma Alismatis to be because its nature and flavor are sweet, cold, enter urinary bladder channel, there is diuretic, eliminating dampness by diuresis, the function expelling the heat-evil, controls dysuria, and edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select Talcum to be because its nature and flavor are sweet, light, cold, return bladder, lung, stomach warp, there is inducing diuresis for treating stranguria syndrome, heat-clearing and toxic substances removing, the function of damp eliminating expelling summer-heat, controls pyretic stranguria, stranguria caused by urinary stone, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea, external treatment eczema, eczema, miliaria.Select Medulla Tetrapanacis to be because its property slightly sweet flavor is cool, enter lung, stomach warp, have eliminating the pathogens from the lung, diuresis, the function of lower milk, controls dysuria, gonorrhea, edema, puerpera's galactostasis, blurred vision, nasal obstruction.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, controls dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Flos Lonicerae to be because its nature and flavor are sweet, cold, enter lung, stomach warp, there is heat clearing away, the function of removing toxic substances, controls epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and the function of subduing inflammation, controls gonorrhea, hematuria, amenorrhea , mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury, ripe in invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Select Semen Plantaginis to be because its nature and flavor are sweet, cold, enter kidney, urinary bladder channel, there is diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.Select Herba Violae to be because its nature and flavor are bitter, cold, enter the heart, Liver Channel, there is clearing away heat-damp and promoting diuresis, the function of removing toxic substances and promoting subsidence of swelling, controls furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom.
The specific embodiment
The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Rhizoma Dioscoreae Septemlobae 140-160 gram of Semen Coicis 290-310 gram of Cortex Phellodendri 90-110 gram
Poria 110-130 gram of Cortex Moutan 140-160 gram of Rhizoma Alismatis 140-160 gram
Talcum 140-160 gram of Medulla Tetrapanacis 40-50 gram of Poria 140-160 gram
Flos Lonicerae 140-160 gram of Radix Achyranthis Bidentatae 140-160 gram of Semen Plantaginis 140-160 gram
Herba Violae 140-160 gram.
Preferable amount is
100 grams of 300 grams of Cortex Phellodendris of 150 grams of Semen Coiciss of Rhizoma Dioscoreae Septemlobae
150 grams of 150 grams of Rhizoma Alismatis of 120 grams of Cortex Moutans of Poria
150 grams, 45 grams of Poria of 150 grams of Medulla Tetrapanaciss of Talcum
150 grams of 150 grams of Semen Plantaginiss of 150 grams of Radix Achyranthis Bidentataes of Flos Lonicerae
150 grams of Herba Violaes.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Rhizoma Dioscoreae Septemlobae: remove impurity, section, cleans, and soaks, and runs through, dry, and sieve removes chip;
2, Semen Coicis: get crude drug, remove residual cot, impurity;
3, Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding, dry;
4, Poria: get Poria piece, remove impurity;
5, Cortex Moutan: choose decontamination, remove core, clean, run through, section, dries;
6, Rhizoma Alismatis: choose decontamination, big or small stepping, is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dries;
7, Talcum: get crude drug, remove impurity, cleaning, drying;
8, Medulla Tetrapanacis: choose decontamination, section;
9, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
10, Flos Lonicerae: sieve removes silt, chooses clean impurity;
11, Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
12, Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;
13, Herba Violae: choose clean impurity, water washes away earth, cutting is dried.
Two, preparation
(1) preparation of capsule
1, described weight Rhizoma Dioscoreae Septemlobae, Semen Coicis, Cortex Phellodendri, Poria, Cortex Moutan, Rhizoma Alismatis, Talcum, Medulla Tetrapanacis, Poria, Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Plantaginis, Herba Violae are decocted with water twice, add for the first time 8 times of amounts of water, decoct 1.5 hours, add for the second time 6 times of amounts of water, decoct 1 hour, merge decoction liquor twice, filter to obtain medicinal liquid.
2, filtrate being condensed into proportion is 1.35 extractum, adds 90%-95% ethanol and carries out precipitate with ethanol, reclaims ethanol concentrated, dry at 45-50 ℃, makes dry extract.
3, dry extract is broken into powder, incapsulates, 0.4 gram every.
(2) preparation of tablet
1, described weight Rhizoma Dioscoreae Septemlobae, Semen Coicis, Cortex Phellodendri, Poria, Cortex Moutan, Rhizoma Alismatis, Talcum, Medulla Tetrapanacis, Poria, Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Plantaginis, Herba Violae are decocted with water twice, add for the first time 8 times of amounts of water, decoct 1.5 hours, add for the second time 6 times of amounts of water, decoct 1 hour, merge decoction liquor twice, filter to obtain medicinal liquid.
2, filtrate being condensed into proportion is 1.35 extractum, adds 90%-95% ethanol and carries out precipitate with ethanol, reclaims ethanol concentrated, dry at 45-50 ℃, makes dry extract.
3, dry extract is broken into fine powder, adds adjuvant, compacting is in blocks, every 0.5 gram.
Medicine of the present invention has clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, and the effect of activating blood circulation and dissipating blood stasis, treatment deep phlebitis instant effect, short treating period, do not recur.
By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.3kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.With distilled water, dry extract is diluted to medicinal liquid, super quantity group is 0.15g/kg, and normal amount is 0.1g/kg, administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observe administration reaction every day, result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's 30 examples for medical treatment.
2, diagnostic criteria
Clinical manifestation
Extremity thrombotic deep phlebitis shows as sick lower limb vein redness, and pain can be touched pain sex cords shape runner or beading sample tuberosity, there is the swelling of suffering limb pitting, during walking, swell and ache and increase the weight of, after reposing, alleviate, skin is kermesinus, has varicosis and telangiectasis widely; Later stage occurs that local malnutrition sexually revises, with the stasis of blood long-pending dermatitis, pigmentation or skin ulcer.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, each serving with 4 grams, every day, early, middle and late respectively clothes 1 time, 15 days was a course for the treatment of, took continuously 3 courses for the treatment of.
4, efficacy assessment standard
Effective: deep phlebitis recovery from illness, it is normal that body constitution is recovered, and observes 1 year without recidivist;
Take a turn for the better: the state of an illness is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy phlebitis patient of the present invention 30 examples, effective 25 examples of result, obvious effective rate is 83.33%, 3 examples that take a turn for the better, and improvement rate is 10%, invalid 2 examples, total effective rate is 93.33%.
Claims (3)
1. a medicine for the treatment of deep phlebitis, is characterized in that: it is to be made by the crude drug in following weight range:
Rhizoma Dioscoreae Septemlobae 140-160 gram of Semen Coicis 290-310 gram of Cortex Phellodendri 90-110 gram
Poria 110-130 gram of Cortex Moutan 140-160 gram of Rhizoma Alismatis 140-160 gram
Talcum 140-160 gram of Medulla Tetrapanacis 40-50 gram of Poria 140-160 gram
Flos Lonicerae 140-160 gram of Radix Achyranthis Bidentatae 140-160 gram of Semen Plantaginis 140-160 gram
Herba Violae 140-160 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
100 grams of 300 grams of Cortex Phellodendris of 150 grams of Semen Coiciss of Rhizoma Dioscoreae Septemlobae
150 grams of 150 grams of Rhizoma Alismatis of 120 grams of Cortex Moutans of Poria
150 grams, 45 grams of Poria of 150 grams of Medulla Tetrapanaciss of Talcum
150 grams of 150 grams of Semen Plantaginiss of 150 grams of Radix Achyranthis Bidentataes of Flos Lonicerae
150 grams of Herba Violaes.
3. according to the preparation method of medicine described in claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Rhizoma Dioscoreae Septemlobae: remove impurity, section, cleans, and soaks, and runs through, dry, and sieve removes chip;
(2) Semen Coicis: get crude drug, remove residual cot, impurity;
(3) Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding, dry;
(4) Poria: get Poria piece, remove impurity;
(5) Cortex Moutan: choose decontamination, remove core, clean, run through, section, dries;
(6) Rhizoma Alismatis: choose decontamination, big or small stepping, is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section, dries;
(7) Talcum: get crude drug, remove impurity, cleaning, drying;
(8) Medulla Tetrapanacis: choose decontamination, section;
(9) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;
(10) Flos Lonicerae: sieve removes silt, chooses clean impurity;
(11) Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
(12) Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;
(13) Herba Violae: choose clean impurity, water washes away earth, cutting is dried;
(2) preparation
(1) preparation of capsule
1. described weight Rhizoma Dioscoreae Septemlobae, Semen Coicis, Cortex Phellodendri, Poria, Cortex Moutan, Rhizoma Alismatis, Talcum, Medulla Tetrapanacis, Poria, Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Plantaginis, Herba Violae are decocted with water twice, add for the first time 8 times of amounts of water, decoct 1.5 hours, add for the second time 6 times of amounts of water, decoct 1 hour, merge decoction liquor twice, filter to obtain medicinal liquid;
2. filtrate is condensed into proportion and is 1.35 extractum, add 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at 45-50 ℃, make dry extract;
3. dry extract is broken into powder, incapsulates, 0.4 gram every;
(2) preparation of tablet
1. described weight Rhizoma Dioscoreae Septemlobae, Semen Coicis, Cortex Phellodendri, Poria, Cortex Moutan, Rhizoma Alismatis, Talcum, Medulla Tetrapanacis, Poria, Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Plantaginis, Herba Violae are decocted with water twice, add for the first time 8 times of amounts of water, decoct 1.5 hours, add for the second time 6 times of amounts of water, decoct 1 hour, merge decoction liquor twice, filter to obtain medicinal liquid;
2. filtrate is condensed into proportion and is 1.35 extractum, add 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at 45-50 ℃, make dry extract;
3. dry extract is broken into fine powder, adds adjuvant, compacting is in blocks, every 0.5 gram.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105596976A (en) * | 2015-11-16 | 2016-05-25 | 孙绪连 | Traditional Chinese medicine decoction for treating thrombophlebitis |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105596976A (en) * | 2015-11-16 | 2016-05-25 | 孙绪连 | Traditional Chinese medicine decoction for treating thrombophlebitis |
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